MARC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.69835190
2exogenous drug catabolic process (GO:0042738)7.17826285
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.88098848
4L-phenylalanine catabolic process (GO:0006559)6.88098848
5L-phenylalanine metabolic process (GO:0006558)6.75068434
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.75068434
7omega-hydroxylase P450 pathway (GO:0097267)6.58201449
8aromatic amino acid family catabolic process (GO:0009074)6.18196884
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.17711749
10tryptophan catabolic process (GO:0006569)5.58530524
11indole-containing compound catabolic process (GO:0042436)5.58530524
12indolalkylamine catabolic process (GO:0046218)5.58530524
13cysteine metabolic process (GO:0006534)5.48801328
14glyoxylate metabolic process (GO:0046487)5.47666005
15ethanol metabolic process (GO:0006067)5.42996838
16kynurenine metabolic process (GO:0070189)5.42576145
17urea metabolic process (GO:0019627)5.41502563
18urea cycle (GO:0000050)5.41502563
19sulfur amino acid catabolic process (GO:0000098)5.36168568
20bile acid biosynthetic process (GO:0006699)5.35590476
21alpha-linolenic acid metabolic process (GO:0036109)5.28497021
22tryptophan metabolic process (GO:0006568)5.26089467
23high-density lipoprotein particle remodeling (GO:0034375)5.21142597
24nitrogen cycle metabolic process (GO:0071941)5.00877106
25regulation of triglyceride catabolic process (GO:0010896)4.94744383
26serine family amino acid catabolic process (GO:0009071)4.91639628
27negative regulation of fibrinolysis (GO:0051918)4.87975285
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85897092
29protein carboxylation (GO:0018214)4.80230775
30peptidyl-glutamic acid carboxylation (GO:0017187)4.80230775
31complement activation, alternative pathway (GO:0006957)4.77052571
32regulation of protein activation cascade (GO:2000257)4.75855112
33homocysteine metabolic process (GO:0050667)4.74039770
34lysine catabolic process (GO:0006554)4.73342488
35lysine metabolic process (GO:0006553)4.73342488
36regulation of cholesterol esterification (GO:0010872)4.70314273
37reverse cholesterol transport (GO:0043691)4.66106229
38regulation of fibrinolysis (GO:0051917)4.65226015
39NADH metabolic process (GO:0006734)4.60400351
40bile acid metabolic process (GO:0008206)4.58929671
41protein-lipid complex remodeling (GO:0034368)4.56416399
42macromolecular complex remodeling (GO:0034367)4.56416399
43plasma lipoprotein particle remodeling (GO:0034369)4.56416399
44amino-acid betaine metabolic process (GO:0006577)4.54973192
45aromatic amino acid family metabolic process (GO:0009072)4.53162764
46regulation of complement activation (GO:0030449)4.47336021
47phospholipid efflux (GO:0033700)4.46318181
48acylglycerol homeostasis (GO:0055090)4.41737853
49triglyceride homeostasis (GO:0070328)4.41737853
50negative regulation of sterol transport (GO:0032372)4.40443309
51negative regulation of cholesterol transport (GO:0032375)4.40443309
52alpha-amino acid catabolic process (GO:1901606)4.35942562
53oxidative demethylation (GO:0070989)4.34578247
54glycine metabolic process (GO:0006544)4.26886167
55protein activation cascade (GO:0072376)4.22171189
56tyrosine metabolic process (GO:0006570)4.20342808
57serine family amino acid metabolic process (GO:0009069)4.18796684
58complement activation, classical pathway (GO:0006958)4.18754866
59plasma lipoprotein particle clearance (GO:0034381)4.18646036
60cellular ketone body metabolic process (GO:0046950)4.15040552
61ethanol oxidation (GO:0006069)4.14428727
62complement activation (GO:0006956)4.13397450
63regulation of plasminogen activation (GO:0010755)4.12692594
64cellular glucuronidation (GO:0052695)4.12653926
65cellular amino acid catabolic process (GO:0009063)4.10176538
66phenylpropanoid metabolic process (GO:0009698)4.08158434
67cellular modified amino acid catabolic process (GO:0042219)4.06317329
68drug catabolic process (GO:0042737)4.03698904
69bile acid and bile salt transport (GO:0015721)4.03692092
70serine family amino acid biosynthetic process (GO:0009070)4.02660356
71fat-soluble vitamin biosynthetic process (GO:0042362)4.01590969
72cholesterol efflux (GO:0033344)4.00881564
73plasma lipoprotein particle assembly (GO:0034377)3.99928541
74coenzyme catabolic process (GO:0009109)3.96336794
75positive regulation of lipoprotein lipase activity (GO:0051006)3.94359407
76positive regulation of triglyceride lipase activity (GO:0061365)3.94359407
77indolalkylamine metabolic process (GO:0006586)3.92038405
78imidazole-containing compound metabolic process (GO:0052803)3.89739191
79glutamate metabolic process (GO:0006536)3.89631321
80negative regulation of protein activation cascade (GO:2000258)3.86928241
81response to mercury ion (GO:0046689)3.85385233
82hormone catabolic process (GO:0042447)3.85014841
83amine catabolic process (GO:0009310)3.84580324
84cellular biogenic amine catabolic process (GO:0042402)3.84580324
85negative regulation of hemostasis (GO:1900047)3.84071424
86negative regulation of blood coagulation (GO:0030195)3.84071424
87benzene-containing compound metabolic process (GO:0042537)3.82755969
88oxaloacetate metabolic process (GO:0006107)3.80451243
89short-chain fatty acid metabolic process (GO:0046459)3.79358895
90flavonoid metabolic process (GO:0009812)3.78287128
91intestinal cholesterol absorption (GO:0030299)3.76566168
92arginine metabolic process (GO:0006525)3.76415919
93very-low-density lipoprotein particle assembly (GO:0034379)3.74120166
94cholesterol homeostasis (GO:0042632)3.72566491
95acute-phase response (GO:0006953)3.68922529
96aldehyde catabolic process (GO:0046185)3.68163865
97sterol homeostasis (GO:0055092)3.67554275
98carboxylic acid catabolic process (GO:0046395)3.67429969
99organic acid catabolic process (GO:0016054)3.67429969
100positive regulation of lipid catabolic process (GO:0050996)3.67389679
101glucuronate metabolic process (GO:0019585)3.66549965
102uronic acid metabolic process (GO:0006063)3.66549965
103low-density lipoprotein particle remodeling (GO:0034374)3.64325255
104drug transmembrane transport (GO:0006855)3.61825268
105protein-lipid complex assembly (GO:0065005)3.60387493
106fructose metabolic process (GO:0006000)3.59699416
107ketone body metabolic process (GO:1902224)3.58410141
108regulation of bile acid biosynthetic process (GO:0070857)3.58238553
109urate metabolic process (GO:0046415)3.57725008
110regulation of cholesterol homeostasis (GO:2000188)3.57490562
111primary alcohol catabolic process (GO:0034310)3.57476894
112acetyl-CoA metabolic process (GO:0006084)3.57320309
113fatty acid beta-oxidation (GO:0006635)3.56869333
114plasma lipoprotein particle organization (GO:0071827)3.55873852
115valine metabolic process (GO:0006573)3.55734330
116negative regulation of coagulation (GO:0050819)3.54820970
117fatty acid oxidation (GO:0019395)3.54279574
118blood coagulation, intrinsic pathway (GO:0007597)3.52258498
119lipoprotein metabolic process (GO:0042157)3.52130111
120drug metabolic process (GO:0017144)3.51172779
121phospholipid homeostasis (GO:0055091)3.50930337
122fibrinolysis (GO:0042730)3.50845453
123regulation of humoral immune response (GO:0002920)3.50839801
124negative regulation of wound healing (GO:0061045)3.43615497
125negative regulation of lipase activity (GO:0060192)3.38017672
126negative regulation of complement activation (GO:0045916)3.36982600
127alkaloid metabolic process (GO:0009820)3.35928569
128proline metabolic process (GO:0006560)3.32897621
129regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.31595996
130primary alcohol metabolic process (GO:0034308)3.25613363
131intestinal absorption (GO:0050892)3.24325885
132carnitine metabolic process (GO:0009437)3.19418139
133monocarboxylic acid catabolic process (GO:0072329)3.14310188
134S-adenosylmethionine metabolic process (GO:0046500)3.13133782
135opsonization (GO:0008228)3.12347498
136positive regulation of fatty acid biosynthetic process (GO:0045723)3.09959173
137daunorubicin metabolic process (GO:0044597)3.09948266
138polyketide metabolic process (GO:0030638)3.09948266
139doxorubicin metabolic process (GO:0044598)3.09948266
140glutamine family amino acid biosynthetic process (GO:0009084)3.09365870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.85289157
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.87061149
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.39617490
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.98491374
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.70331803
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85141606
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.70595551
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80656774
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.51271687
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.40022111
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47667918
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44669573
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1508117
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95721356
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94167958
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.90119559
17GATA1_22025678_ChIP-Seq_K562_Human1.80731377
18CLOCK_20551151_ChIP-Seq_293T_Human1.77661084
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66889493
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.58878804
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49902696
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43654907
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40392332
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37943616
25HNF4A_19822575_ChIP-Seq_HepG2_Human1.35712467
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.35298032
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27632895
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25320257
29RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18621530
30GATA4_25053715_ChIP-Seq_YYC3_Human1.17173576
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16970270
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11553191
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.11525865
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.11525865
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08153251
36HTT_18923047_ChIP-ChIP_STHdh_Human1.06643681
37AR_21909140_ChIP-Seq_LNCAP_Human1.05554855
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03341008
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02631420
40ZNF263_19887448_ChIP-Seq_K562_Human1.01318544
41PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00310254
42EP300_21415370_ChIP-Seq_HL-1_Mouse0.98425453
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98014286
44CDX2_20551321_ChIP-Seq_CACO-2_Human0.95853962
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95540324
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94780354
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92845335
48CTCF_27219007_Chip-Seq_Bcells_Human0.92354998
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91315313
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91110390
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90854372
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89155582
53CBP_21632823_ChIP-Seq_H3396_Human0.87059328
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86932745
55ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86843643
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86525621
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86023140
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85973729
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85139530
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82742628
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81929498
62PIAS1_25552417_ChIP-Seq_VCAP_Human0.80529712
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79611845
64RARA_24833708_ChIP-Seq_LIVER_Mouse0.79017891
65GATA6_25053715_ChIP-Seq_YYC3_Human0.78061138
66KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76172299
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75143237
68LXR_22292898_ChIP-Seq_THP-1_Human0.74676253
69ESR2_21235772_ChIP-Seq_MCF-7_Human0.74091050
70TP53_18474530_ChIP-ChIP_U2OS_Human0.72952159
71NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72809283
72TCF4_18268006_ChIP-ChIP_LS174T_Human0.72730396
73TP63_17297297_ChIP-ChIP_HaCaT_Human0.72454290
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.72297937
75ERG_21242973_ChIP-ChIP_JURKAT_Human0.71921959
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71904464
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71213344
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70885624
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70860555
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70368247
81HNFA_21074721_ChIP-Seq_CACO-2_Human0.69453611
82RARB_24833708_ChIP-Seq_LIVER_Mouse0.68315591
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68244055
84DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67534736
85RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67358338
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65509810
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64701622
88CEBPB_22108803_ChIP-Seq_LS180_Human0.64543681
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.64408976
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63665538
91SMC4_20622854_ChIP-Seq_HELA_Human0.63609123
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62800232
93AR_20517297_ChIP-Seq_VCAP_Human0.62763157
94SOX2_20726797_ChIP-Seq_SW620_Human0.62525160
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.62443703
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.62106094
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.61922220
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.61584373
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61552272
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61481819
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61481819
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.61431498
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.60924492
104SOX2_21211035_ChIP-Seq_LN229_Human0.60610415
105PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59749081
106BRD4_27068464_Chip-Seq_AML-cells_Mouse0.58448861
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.58060356
108MYC_27129775_Chip-Seq_CORNEA_Mouse0.58008059
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57928879
110RACK7_27058665_Chip-Seq_MCF-7_Human0.57701107
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.55097208
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54876783
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.53716240
114GATA2_19941826_ChIP-Seq_K562_Human0.53594768
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52641015
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52595689
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.52068348
118EGR1_19032775_ChIP-ChIP_M12_Human0.52047662
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51596214
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.50772648
121BCOR_27268052_Chip-Seq_Bcells_Human0.50432323
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50175198
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.49469924
124GATA1_19941826_ChIP-Seq_K562_Human0.48796677
125P53_21459846_ChIP-Seq_SAOS-2_Human0.47728488
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47260808
127TAF2_19829295_ChIP-Seq_ESCs_Human0.47092730
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.46866899
129ERG_20517297_ChIP-Seq_VCAP_Human0.46724052
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.46607696
131ESET_19884257_ChIP-Seq_ESCs_Mouse0.46251691
132BCL6_27268052_Chip-Seq_Bcells_Human0.45421258
133MYC_19915707_ChIP-ChIP_AK7_Human0.45323851
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.45303965
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.45239591
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.44866895
137ATF3_27146783_Chip-Seq_COLON_Human0.44516975
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.44355037
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.43951667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.71455860
2MP0005360_urolithiasis7.57060169
3MP0005085_abnormal_gallbladder_physiolo5.83275411
4MP0005365_abnormal_bile_salt5.70463910
5MP0008875_abnormal_xenobiotic_pharmacok4.73513246
6MP0003806_abnormal_nucleotide_metabolis3.98780442
7MP0003252_abnormal_bile_duct3.66140419
8MP0010329_abnormal_lipoprotein_level3.46833058
9MP0009840_abnormal_foam_cell3.30209766
10MP0001666_abnormal_nutrient_absorption2.90465536
11MP0005332_abnormal_amino_acid2.83101244
12MP0005083_abnormal_biliary_tract2.70849147
13MP0003195_calcinosis2.53767336
14MP0003191_abnormal_cellular_cholesterol2.39111961
15MP0004019_abnormal_vitamin_homeostasis2.33035109
16MP0000609_abnormal_liver_physiology2.11962636
17MP0002138_abnormal_hepatobiliary_system2.03051338
18MP0002118_abnormal_lipid_homeostasis2.02990711
19MP0005319_abnormal_enzyme/_coenzyme1.83197622
20MP0003868_abnormal_feces_composition1.77746128
21MP0001764_abnormal_homeostasis1.75602773
22MP0009643_abnormal_urine_homeostasis1.56882381
23MP0005584_abnormal_enzyme/coenzyme_acti1.56602385
24MP0003186_abnormal_redox_activity1.55294231
25MP0003656_abnormal_erythrocyte_physiolo1.36806008
26MP0009697_abnormal_copulation1.33403344
27MP0003011_delayed_dark_adaptation1.30824563
28MP0005451_abnormal_body_composition1.28659035
29MP0000751_myopathy1.28484525
30MP0002254_reproductive_system_inflammat1.24371301
31MP0003705_abnormal_hypodermis_morpholog1.22249832
32MP0000598_abnormal_liver_morphology1.18482682
33MP0005636_abnormal_mineral_homeostasis1.17762326
34MP0009764_decreased_sensitivity_to1.14116280
35MP0005670_abnormal_white_adipose1.10626504
36MP0000566_synostosis1.10559039
37MP0003879_abnormal_hair_cell1.09815390
38MP0005647_abnormal_sex_gland1.08090587
39MP0006138_congestive_heart_failure1.04860464
40MP0005084_abnormal_gallbladder_morpholo1.01691291
41MP0002249_abnormal_larynx_morphology1.01214701
42MP0005375_adipose_tissue_phenotype1.01024785
43MP0009763_increased_sensitivity_to1.00949470
44MP0005330_cardiomyopathy1.00121389
45MP0008469_abnormal_protein_level1.00032694
46MP0004185_abnormal_adipocyte_glucose0.99670030
47MP0006036_abnormal_mitochondrial_physio0.99272288
48MP0004036_abnormal_muscle_relaxation0.90426370
49MP0005187_abnormal_penis_morphology0.90312800
50MP0009642_abnormal_blood_homeostasis0.89517896
51MP0000678_abnormal_parathyroid_gland0.87668991
52MP0002876_abnormal_thyroid_physiology0.87429986
53MP0003183_abnormal_peptide_metabolism0.86936064
54MP0010368_abnormal_lymphatic_system0.84692279
55MP0000604_amyloidosis0.83321271
56MP0004130_abnormal_muscle_cell0.83254934
57MP0002971_abnormal_brown_adipose0.82961221
58MP0005220_abnormal_exocrine_pancreas0.82801830
59MP0004272_abnormal_basement_membrane0.82648373
60MP0009765_abnormal_xenobiotic_induced0.82181972
61MP0001756_abnormal_urination0.82045476
62MP0005376_homeostasis/metabolism_phenot0.82041777
63MP0003724_increased_susceptibility_to0.80673816
64MP0002078_abnormal_glucose_homeostasis0.75951487
65MP0005334_abnormal_fat_pad0.75018704
66MP0002136_abnormal_kidney_physiology0.74796031
67MP0005408_hypopigmentation0.73956328
68MP0004087_abnormal_muscle_fiber0.72281011
69MP0005666_abnormal_adipose_tissue0.72118084
70MP0004084_abnormal_cardiac_muscle0.71429740
71MP0010234_abnormal_vibrissa_follicle0.69492831
72MP0005464_abnormal_platelet_physiology0.66565759
73MP0002972_abnormal_cardiac_muscle0.66340667
74MP0009780_abnormal_chondrocyte_physiolo0.66206919
75MP0000013_abnormal_adipose_tissue0.65578787
76MP0005266_abnormal_metabolism0.65304158
77MP0001661_extended_life_span0.64920394
78MP0001544_abnormal_cardiovascular_syste0.64632516
79MP0005385_cardiovascular_system_phenoty0.64632516
80MP0000003_abnormal_adipose_tissue0.64118077
81MP0002168_other_aberrant_phenotype0.64012772
82MP0004145_abnormal_muscle_electrophysio0.63925940
83MP0004215_abnormal_myocardial_fiber0.62163175
84MP0005535_abnormal_body_temperature0.60342638
85MP0005409_darkened_coat_color0.58764926
86MP0008775_abnormal_heart_ventricle0.58652590
87MP0002796_impaired_skin_barrier0.58361219
88MP0004264_abnormal_extraembryonic_tissu0.58152122
89MP0005448_abnormal_energy_balance0.57935211
90MP0003638_abnormal_response/metabolism_0.57330732
91MP0003300_gastrointestinal_ulcer0.56748851
92MP0000747_muscle_weakness0.56612439
93MP0003436_decreased_susceptibility_to0.56297816
94MP0000749_muscle_degeneration0.55859070
95MP0005620_abnormal_muscle_contractility0.55800111
96MP0005058_abnormal_lysosome_morphology0.55275401
97MP0004043_abnormal_pH_regulation0.54998556
98MP0004147_increased_porphyrin_level0.54789691
99MP0006035_abnormal_mitochondrial_morpho0.52962775
100MP0002132_abnormal_respiratory_system0.52767840
101MP0000462_abnormal_digestive_system0.51675846
102MP0009115_abnormal_fat_cell0.51596986
103MP0003718_maternal_effect0.51426042
104MP0003329_amyloid_beta_deposits0.51364604
105MP0002269_muscular_atrophy0.51105655
106MP0009384_cardiac_valve_regurgitation0.50757745
107MP0010630_abnormal_cardiac_muscle0.50653634
108MP0001853_heart_inflammation0.50287957
109MP0001845_abnormal_inflammatory_respons0.49246878
110MP0005395_other_phenotype0.49160890
111MP0000537_abnormal_urethra_morphology0.48747035
112MP0002896_abnormal_bone_mineralization0.48414633
113MP0000639_abnormal_adrenal_gland0.46641132
114MP0009053_abnormal_anal_canal0.46440987
115MP0004782_abnormal_surfactant_physiolog0.46331395
116MP0002909_abnormal_adrenal_gland0.46230039
117MP0001765_abnormal_ion_homeostasis0.45863317
118MP0008873_increased_physiological_sensi0.45678407
119MP0005166_decreased_susceptibility_to0.44157191
120MP0001881_abnormal_mammary_gland0.42448461
121MP0004858_abnormal_nervous_system0.42246086
122MP0010155_abnormal_intestine_physiology0.42096526
123MP0002928_abnormal_bile_duct0.41809741
124MP0002970_abnormal_white_adipose0.41802774
125MP0003690_abnormal_glial_cell0.41575357
126MP0003953_abnormal_hormone_level0.41283010
127MP0009379_abnormal_foot_pigmentation0.40708954
128MP0003075_altered_response_to0.40099154
129MP0006082_CNS_inflammation0.38878682
130MP0002060_abnormal_skin_morphology0.38802828
131MP0000249_abnormal_blood_vessel0.38520434
132MP0000230_abnormal_systemic_arterial0.38225426
133MP0000685_abnormal_immune_system0.36990607
134MP0003453_abnormal_keratinocyte_physiol0.36834949
135MP0009785_altered_susceptibility_to0.35311156
136MP0008872_abnormal_physiological_respon0.34861103
137MP0002135_abnormal_kidney_morphology0.34559365

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.79547148
2Intrahepatic cholestasis (HP:0001406)6.51389609
3Deep venous thrombosis (HP:0002625)6.35085980
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.13438880
5Hypobetalipoproteinemia (HP:0003563)5.96074451
6Xanthomatosis (HP:0000991)5.90820513
7Prolonged partial thromboplastin time (HP:0003645)5.62558964
8Hyperlipoproteinemia (HP:0010980)4.99927398
9Complement deficiency (HP:0004431)4.69000599
10Hyperammonemia (HP:0001987)4.68045878
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.57180584
12Hypolipoproteinemia (HP:0010981)4.51883898
13Hyperglycinuria (HP:0003108)4.43515628
14Hyperglycinemia (HP:0002154)4.30581641
15Ketosis (HP:0001946)4.24621994
16Joint hemorrhage (HP:0005261)4.19687074
17Abnormality of serine family amino acid metabolism (HP:0010894)4.17484120
18Abnormality of glycine metabolism (HP:0010895)4.17484120
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14052330
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.02372484
21Epidermoid cyst (HP:0200040)4.02273877
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.01150719
23Abnormality of the common coagulation pathway (HP:0010990)3.98236117
24Fat malabsorption (HP:0002630)3.94468560
25Hypoglycemic coma (HP:0001325)3.92138385
26Hypoalphalipoproteinemia (HP:0003233)3.91256183
27Abnormality of methionine metabolism (HP:0010901)3.75233350
28Abnormality of pyrimidine metabolism (HP:0004353)3.64367115
29Abnormality of fatty-acid metabolism (HP:0004359)3.58793554
30Abnormality of the intrinsic pathway (HP:0010989)3.56624245
31Conjugated hyperbilirubinemia (HP:0002908)3.48657029
32Abnormality of complement system (HP:0005339)3.44372847
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42827762
34Hypercholesterolemia (HP:0003124)3.39904751
35Nephritis (HP:0000123)3.37812299
36Hyperbilirubinemia (HP:0002904)3.27289890
37Abnormality of nucleobase metabolism (HP:0010932)3.26345365
38Ketoacidosis (HP:0001993)3.22095473
39Abnormality of serum amino acid levels (HP:0003112)3.08645556
40Abnormality of purine metabolism (HP:0004352)3.07334490
41Delayed CNS myelination (HP:0002188)3.02427626
42Metabolic acidosis (HP:0001942)2.93475880
43Dicarboxylic aciduria (HP:0003215)2.89296261
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89296261
45Steatorrhea (HP:0002570)2.87135456
46Hepatocellular carcinoma (HP:0001402)2.79499995
47Lethargy (HP:0001254)2.79051560
48Gout (HP:0001997)2.76048517
49Myocardial infarction (HP:0001658)2.74992355
50Acanthocytosis (HP:0001927)2.72786971
51Malnutrition (HP:0004395)2.69221026
52Increased serum pyruvate (HP:0003542)2.54896783
53Abnormality of vitamin metabolism (HP:0100508)2.53142990
54Systemic lupus erythematosus (HP:0002725)2.51508387
55Vascular calcification (HP:0004934)2.51326765
56Generalized aminoaciduria (HP:0002909)2.48878132
57Cerebral edema (HP:0002181)2.47761927
58Spontaneous abortion (HP:0005268)2.47610052
59Skin nodule (HP:0200036)2.46555974
60Spastic diplegia (HP:0001264)2.44645987
61Exercise-induced myalgia (HP:0003738)2.41468023
62Abnormality of proline metabolism (HP:0010907)2.38596094
63Hydroxyprolinuria (HP:0003080)2.38596094
64Pancreatitis (HP:0001733)2.37428446
65Hypoglycemic seizures (HP:0002173)2.35880085
66Hypochromic microcytic anemia (HP:0004840)2.32743424
67Rhabdomyolysis (HP:0003201)2.28902895
68Abnormality of glycolysis (HP:0004366)2.28690058
69Osteomalacia (HP:0002749)2.28221730
70Irritability (HP:0000737)2.27826864
71Late onset (HP:0003584)2.27347945
72Vomiting (HP:0002013)2.26906896
73Cardiovascular calcification (HP:0011915)2.23643275
74Proximal tubulopathy (HP:0000114)2.21065065
75Atrioventricular block (HP:0001678)2.18597699
76Esophageal varix (HP:0002040)2.17571059
77Amyloidosis (HP:0011034)2.16671407
78Neonatal onset (HP:0003623)2.15713248
79Alkalosis (HP:0001948)2.13236153
80Abnormal gallbladder morphology (HP:0012437)2.13039486
81Sensorimotor neuropathy (HP:0007141)2.12935227
82Cholelithiasis (HP:0001081)2.12585234
83Glomerulonephritis (HP:0000099)2.12400941
84Glycosuria (HP:0003076)2.11160612
85Abnormality of urine glucose concentration (HP:0011016)2.11160612
86Gingival bleeding (HP:0000225)2.10871177
87Menorrhagia (HP:0000132)2.10756302
88Brushfield spots (HP:0001088)2.10089963
89Nausea (HP:0002018)2.09470011
90Myoglobinuria (HP:0002913)2.08576531
91Abnormal cartilage morphology (HP:0002763)2.07677457
92Poikilocytosis (HP:0004447)2.07664811
93Hyperuricemia (HP:0002149)2.06832074
94Increased purine levels (HP:0004368)2.06832074
95Hyperphosphaturia (HP:0003109)2.05629034
96Recurrent gram-negative bacterial infections (HP:0005420)2.05314338
97Abnormality of transition element cation homeostasis (HP:0011030)2.04882232
98Cholecystitis (HP:0001082)2.03089435
99Abnormal gallbladder physiology (HP:0012438)2.03089435
100Abnormality of iron homeostasis (HP:0011031)1.99648127
101Thrombophlebitis (HP:0004418)1.97340571
102Facial shape deformation (HP:0011334)1.93810173
103Potter facies (HP:0002009)1.93810173
104Opisthotonus (HP:0002179)1.93454282
105Mitral stenosis (HP:0001718)1.93400959
106Enlarged kidneys (HP:0000105)1.91419727
107Elevated hepatic transaminases (HP:0002910)1.91187784
108Abnormal urine phosphate concentration (HP:0012599)1.89944351
109Hypertriglyceridemia (HP:0002155)1.89359056
110Muscle fiber inclusion bodies (HP:0100299)1.88736414
111Hyperinsulinemic hypoglycemia (HP:0000825)1.87946183
112Abnormal enzyme/coenzyme activity (HP:0012379)1.87129127
113Rickets (HP:0002748)1.86807840
114Nemaline bodies (HP:0003798)1.83936101
115Hemorrhage of the eye (HP:0011885)1.82627716
116Hypophosphatemia (HP:0002148)1.82276179
117Abnormality of the Achilles tendon (HP:0005109)1.81189158
118Megaloblastic anemia (HP:0001889)1.80621575
119Heart block (HP:0012722)1.79901497
120Abnormal atrioventricular conduction (HP:0005150)1.77845881
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76136422
122Neonatal hypoglycemia (HP:0001998)1.73536309
123Bifid scrotum (HP:0000048)1.72813961
124Pigmentary retinal degeneration (HP:0001146)1.72802013
125Nephrolithiasis (HP:0000787)1.72581209
126Cerebral palsy (HP:0100021)1.69875843
127Elevated alkaline phosphatase (HP:0003155)1.68861412
128Confusion (HP:0001289)1.66908300
129Widely patent fontanelles and sutures (HP:0004492)1.65694107
130Focal segmental glomerulosclerosis (HP:0000097)1.65634115
131Purpura (HP:0000979)1.64809174
132Type 1 muscle fiber predominance (HP:0003803)1.61445944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.78692788
2ERN14.77020171
3SIK13.89407126
4OBSCN3.64572872
5FGFR43.58355133
6TAOK32.66013357
7MST1R2.40075539
8TRIB32.39535687
9EPHA22.36000785
10PDK22.34845135
11EPHB22.27016857
12PKN22.24150506
13FLT32.21712637
14INSRR2.06385128
15TTN1.96584322
16FRK1.94558291
17DMPK1.92463726
18TYK21.80933607
19PIK3CG1.80350753
20MAPK111.78118798
21ERBB41.71173068
22KDR1.70463400
23PHKG11.58350408
24PHKG21.58350408
25IRAK31.53783372
26NME21.52277499
27GRK61.48860504
28PTK61.47719354
29NEK91.44487564
30TIE11.42465998
31LATS11.40285335
32TBK11.37106199
33PDGFRA1.33800940
34LATS21.31109034
35MAP3K111.23941453
36MAP3K101.22205735
37ABL21.21217689
38TESK11.18257696
39PRKAA21.18255891
40MAP2K31.18065107
41MAP2K41.16018888
42MUSK1.15064141
43MAP3K71.13063978
44MAP3K31.11399309
45JAK21.10913261
46TGFBR21.10094635
47PRPF4B1.05613175
48ICK1.00667538
49ARAF1.00015485
50STK390.97377169
51FER0.97026918
52KSR20.92084773
53MAP4K10.91232155
54NTRK10.91028361
55JAK10.90703667
56AKT20.90351973
57PINK10.88006468
58MAPK40.87917118
59RIPK10.87846238
60MAP3K140.87050313
61LMTK20.86674902
62SGK2230.85914835
63SGK4940.85914835
64MAP3K20.85019882
65MAP2K20.84244056
66MAP2K60.82756126
67MAPKAPK30.82675924
68MAPK150.81135952
69DYRK1B0.80721210
70AKT30.80377981
71SCYL20.77133649
72CAMK1D0.77049049
73IKBKE0.76767305
74EPHB10.76437345
75CDK60.75643167
76SGK20.74687079
77ERBB20.74059243
78CSF1R0.72748274
79PRKG20.71300625
80CSK0.71241079
81OXSR10.70336490
82LRRK20.70287615
83SGK30.70070274
84MAPK120.69884723
85RET0.69511351
86DDR20.68517580
87CAMK2D0.68327955
88CAMK2B0.67375907
89MET0.67044573
90STK240.66205489
91KIT0.65674307
92NLK0.65173607
93STK38L0.62989737
94GRK10.59026236
95CDK40.58419173
96GSK3A0.58412965
97PRKD30.57686347
98PRKAA10.57323639
99JAK30.56694906
100BRSK20.54651869
101ZAP700.53096244
102PRKG10.52475716
103DAPK20.51925899
104PRKACG0.50225568
105PRKACA0.50116539
106EPHA30.49683737
107ACVR1B0.49394664
108PIM20.46984298
109MYLK0.46717920
110PRKCZ0.46034256
111MAP3K60.45815305
112PAK40.44716536
113EIF2AK10.43635501
114PTK20.43399281
115RPS6KA30.42667893
116GRK50.42329211
117NEK60.41892709
118BLK0.41482927
119CAMK2G0.40910314
120STK160.40152469
121STK100.39730525
122MAP3K120.39502664
123PDK10.39245945
124MAP2K10.39007510
125LIMK10.38989988
126PDPK10.38976304
127PRKD10.38361023
128TEC0.37940606
129MTOR0.37311378
130NTRK30.36584156
131PDK30.36494983
132PDK40.36494983
133PBK0.36395028
134PIK3CA0.36256045
135BTK0.35953990
136MAP3K50.35922223
137SGK10.34079576
138MAP3K130.33674204
139FGFR30.33302148
140IGF1R0.32210722
141IRAK10.31987857
142WNK40.31526947
143MAPK70.30397955
144PRKCQ0.30050314
145PIM10.29581355
146MAP3K10.29260108
147NEK10.29217930
148EEF2K0.29161119
149MATK0.29131913

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06861719
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40738300
3Nitrogen metabolism_Homo sapiens_hsa009103.38822850
4Arginine biosynthesis_Homo sapiens_hsa002202.89428897
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86760179
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62113442
7Fatty acid degradation_Homo sapiens_hsa000712.60946833
8Tryptophan metabolism_Homo sapiens_hsa003802.60454665
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50552670
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45868688
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43190406
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42496388
13Complement and coagulation cascades_Homo sapiens_hsa046102.42139666
14Peroxisome_Homo sapiens_hsa041462.10835270
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09183261
16Propanoate metabolism_Homo sapiens_hsa006402.06240138
17Butanoate metabolism_Homo sapiens_hsa006501.99515063
18PPAR signaling pathway_Homo sapiens_hsa033201.96609585
19Histidine metabolism_Homo sapiens_hsa003401.90109216
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89618104
21Chemical carcinogenesis_Homo sapiens_hsa052041.89397776
22Caffeine metabolism_Homo sapiens_hsa002321.87604519
23Fatty acid metabolism_Homo sapiens_hsa012121.83827348
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77732443
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.76162487
26beta-Alanine metabolism_Homo sapiens_hsa004101.75033188
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70032503
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68963020
29Folate biosynthesis_Homo sapiens_hsa007901.62283622
30Retinol metabolism_Homo sapiens_hsa008301.59843367
31Selenocompound metabolism_Homo sapiens_hsa004501.58553288
32Fat digestion and absorption_Homo sapiens_hsa049751.55575839
33Sulfur metabolism_Homo sapiens_hsa009201.52034844
34Staphylococcus aureus infection_Homo sapiens_hsa051501.51000853
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50942383
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45665248
37Pyruvate metabolism_Homo sapiens_hsa006201.45651096
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44879982
39Bile secretion_Homo sapiens_hsa049761.44871854
40Starch and sucrose metabolism_Homo sapiens_hsa005001.41692430
41Phenylalanine metabolism_Homo sapiens_hsa003601.39332630
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.29885688
43Tyrosine metabolism_Homo sapiens_hsa003501.26516344
44Biosynthesis of amino acids_Homo sapiens_hsa012301.25725698
45Carbon metabolism_Homo sapiens_hsa012001.25430852
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.24643107
47Fatty acid elongation_Homo sapiens_hsa000621.23026515
48Sulfur relay system_Homo sapiens_hsa041221.22118956
49Vitamin digestion and absorption_Homo sapiens_hsa049771.19827214
50ABC transporters_Homo sapiens_hsa020101.15310893
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09149573
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.06923918
53Arginine and proline metabolism_Homo sapiens_hsa003301.06168918
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05708632
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98227883
56Steroid biosynthesis_Homo sapiens_hsa001000.95345800
57Glutathione metabolism_Homo sapiens_hsa004800.91324092
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90928843
59Glycerolipid metabolism_Homo sapiens_hsa005610.83736390
60Pentose phosphate pathway_Homo sapiens_hsa000300.81472447
61Vitamin B6 metabolism_Homo sapiens_hsa007500.80966273
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79659074
63One carbon pool by folate_Homo sapiens_hsa006700.78135038
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76180928
65Lysine degradation_Homo sapiens_hsa003100.75758708
66Fatty acid biosynthesis_Homo sapiens_hsa000610.64953638
67Galactose metabolism_Homo sapiens_hsa000520.54463821
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54062356
69Metabolic pathways_Homo sapiens_hsa011000.53765133
70Fructose and mannose metabolism_Homo sapiens_hsa000510.49978074
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33694776
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.25374312
73Linoleic acid metabolism_Homo sapiens_hsa005910.25098648
74Insulin resistance_Homo sapiens_hsa049310.22563789
75Renin-angiotensin system_Homo sapiens_hsa046140.22462377
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19539834
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.16274114
78Prion diseases_Homo sapiens_hsa050200.15453981
79Pertussis_Homo sapiens_hsa051330.14331792
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11518265
81Circadian rhythm_Homo sapiens_hsa047100.07951697
82AMPK signaling pathway_Homo sapiens_hsa041520.04334946
83Ovarian steroidogenesis_Homo sapiens_hsa049130.03361969
84Arachidonic acid metabolism_Homo sapiens_hsa005900.02227247
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.01812527
86Amoebiasis_Homo sapiens_hsa051460.00450822
87Protein digestion and absorption_Homo sapiens_hsa049740.00153801
88Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1760591
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1750971
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1737862
91Regulation of autophagy_Homo sapiens_hsa04140-0.1731185
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1707148
93Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1639178
94Bladder cancer_Homo sapiens_hsa05219-0.1568539
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1442402
96Insulin signaling pathway_Homo sapiens_hsa04910-0.1282060
97Pyrimidine metabolism_Homo sapiens_hsa00240-0.1260466
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0882347
99Hepatitis C_Homo sapiens_hsa05160-0.0862110
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0638986
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0595820
102Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0554406
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.0524572
104Renin secretion_Homo sapiens_hsa04924-0.0402107
105Tight junction_Homo sapiens_hsa04530-0.0371318
106Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0361380
107Other glycan degradation_Homo sapiens_hsa00511-0.0357649
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0332918
109Glucagon signaling pathway_Homo sapiens_hsa04922-0.0205168
110Pancreatic secretion_Homo sapiens_hsa04972-0.0150293
111Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0125963
112Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0119859
113Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0099622
114Mineral absorption_Homo sapiens_hsa04978-0.0057934

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