MAPKAPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27273286
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27273286
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.27273286
4modulation by symbiont of host immune response (GO:0052553)5.27273286
5positive regulation by symbiont of host defense response (GO:0052509)5.27273286
6modulation by symbiont of host defense response (GO:0052031)5.27273286
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.37167541
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37167541
9negative regulation of erythrocyte differentiation (GO:0045647)4.20429423
10low-density lipoprotein particle clearance (GO:0034383)3.87315076
11antigen processing and presentation of endogenous antigen (GO:0019883)3.83696468
12response to peptidoglycan (GO:0032494)3.81483253
13positive regulation of gamma-delta T cell activation (GO:0046645)3.71088614
14response to muramyl dipeptide (GO:0032495)3.63815917
15regulation of interferon-beta biosynthetic process (GO:0045357)3.53549832
16macrophage activation involved in immune response (GO:0002281)3.49799870
17positive regulation of interferon-alpha production (GO:0032727)3.42622982
18positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.41973604
19regulation of interferon-alpha production (GO:0032647)3.33703110
20response to host immune response (GO:0052572)3.33026144
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33026144
22negative regulation of interleukin-12 production (GO:0032695)3.29400694
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24839116
24response to host (GO:0075136)3.24839116
25response to host defenses (GO:0052200)3.24839116
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24732136
27regulation of vitamin D biosynthetic process (GO:0060556)3.20957247
28regulation of interleukin-12 biosynthetic process (GO:0045075)3.19539841
29regulation of cholesterol storage (GO:0010885)3.18858950
30mannose metabolic process (GO:0006013)3.12395180
31positive regulation of lipid storage (GO:0010884)3.08933279
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01892027
33detection of other organism (GO:0098543)2.99792549
34positive regulation of chemokine biosynthetic process (GO:0045080)2.97563197
35positive regulation of p38MAPK cascade (GO:1900745)2.94483469
36regulation of T-helper 2 cell differentiation (GO:0045628)2.94439054
37sarcomere organization (GO:0045214)2.90172129
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.89863994
39neutrophil activation involved in immune response (GO:0002283)2.89759958
40regulation of gamma-delta T cell activation (GO:0046643)2.89574788
41detection of bacterium (GO:0016045)2.87073881
42regulation of membrane protein ectodomain proteolysis (GO:0051043)2.85443937
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83804641
44positive regulation of Cdc42 GTPase activity (GO:0043089)2.82985815
45NIK/NF-kappaB signaling (GO:0038061)2.81614132
46positive regulation of histone deacetylation (GO:0031065)2.81179561
47regulation of gamma-delta T cell differentiation (GO:0045586)2.79146843
48stress fiber assembly (GO:0043149)2.78968115
49cell adhesion mediated by integrin (GO:0033627)2.78576526
50pentose-phosphate shunt (GO:0006098)2.77856169
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77567043
52immunoglobulin mediated immune response (GO:0016064)2.77509804
53regulation of necroptotic process (GO:0060544)2.73317345
54apoptotic cell clearance (GO:0043277)2.71568008
55respiratory burst (GO:0045730)2.71264778
56regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68649910
57regulation of vitamin metabolic process (GO:0030656)2.67624344
58regulation of T-helper 1 cell differentiation (GO:0045625)2.65580165
59negative regulation of cytokine production involved in immune response (GO:0002719)2.64299685
60regulation of early endosome to late endosome transport (GO:2000641)2.60948537
61activation of MAPKKK activity (GO:0000185)2.58292752
62leukocyte aggregation (GO:0070486)2.58153370
63detection of external biotic stimulus (GO:0098581)2.57674841
64positive regulation of heat generation (GO:0031652)2.57588102
65cellular extravasation (GO:0045123)2.57480357
66barbed-end actin filament capping (GO:0051016)2.57236463
67positive regulation of B cell differentiation (GO:0045579)2.56768247
68cellular response to thyroid hormone stimulus (GO:0097067)2.55353222
69regulation of podosome assembly (GO:0071801)2.54877293
70positive regulation of natural killer cell differentiation (GO:0032825)2.52515092
71cellular response to zinc ion (GO:0071294)2.50476792
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50218150
73growth hormone receptor signaling pathway (GO:0060396)2.49650512
74positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49593502
75regulation of p38MAPK cascade (GO:1900744)2.49163380
76plasma membrane repair (GO:0001778)2.49069990
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.48479014
78I-kappaB phosphorylation (GO:0007252)2.48137292
79defense response to protozoan (GO:0042832)2.47404371
80T cell apoptotic process (GO:0070231)2.47129260
81positive regulation of interferon-beta production (GO:0032728)2.47035090
82tolerance induction (GO:0002507)2.46597913
83response to protozoan (GO:0001562)2.46418142
84actin-myosin filament sliding (GO:0033275)2.44913398
85muscle filament sliding (GO:0030049)2.44913398
86interferon-gamma-mediated signaling pathway (GO:0060333)2.44908910
87regulation of integrin activation (GO:0033623)2.44799765
88cardiac myofibril assembly (GO:0055003)2.44412757
89regulation of necrotic cell death (GO:0010939)2.44278385
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.43909346
91regulation of leukocyte degranulation (GO:0043300)2.43847368
92NADPH regeneration (GO:0006740)2.42694796
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.42594629
94response to type I interferon (GO:0034340)2.42160099
95regulation of interleukin-8 biosynthetic process (GO:0045414)2.41247232
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39396505
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39297776
98myofibril assembly (GO:0030239)2.38669630
99type I interferon signaling pathway (GO:0060337)2.38556603
100cellular response to type I interferon (GO:0071357)2.38556603
101T-helper 1 type immune response (GO:0042088)2.38307804
102negative regulation of growth of symbiont in host (GO:0044130)2.36843679
103negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.36843679
104modulation of growth of symbiont involved in interaction with host (GO:0044144)2.36843679
105regulation of growth of symbiont in host (GO:0044126)2.36843679
106positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36438503
107negative regulation of lipid storage (GO:0010888)2.36244528
108response to fungus (GO:0009620)2.35119500
109negative regulation of necroptotic process (GO:0060546)2.34899475
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.34341635
111myeloid dendritic cell activation (GO:0001773)2.34027678
112adhesion of symbiont to host cell (GO:0044650)2.33787157
113virion attachment to host cell (GO:0019062)2.33787157
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33444633
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32967328
116neutrophil mediated immunity (GO:0002446)2.32738954
117response to laminar fluid shear stress (GO:0034616)2.32371061
118germinal center formation (GO:0002467)2.32154536
119glycosphingolipid catabolic process (GO:0046479)2.31906058
120detection of molecule of bacterial origin (GO:0032490)2.31534819
121leukocyte cell-cell adhesion (GO:0007159)2.31279681
122detection of biotic stimulus (GO:0009595)2.29619038
123positive regulation of antigen processing and presentation (GO:0002579)2.29415187
124protein localization to endosome (GO:0036010)2.29176320
125regulation of type 2 immune response (GO:0002828)2.29144436
126regulation of mast cell degranulation (GO:0043304)2.28492682
127modification by symbiont of host morphology or physiology (GO:0044003)2.28342151
128positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.27856647
129positive regulation of type 2 immune response (GO:0002830)2.27356540
130myeloid dendritic cell differentiation (GO:0043011)2.27180872
131negative regulation of cell killing (GO:0031342)2.26795841
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26795841
133apoptotic process involved in morphogenesis (GO:0060561)2.26740499
134positive thymic T cell selection (GO:0045059)2.26243273
135regulation of lipid storage (GO:0010883)2.26017573
136regulation of chemokine biosynthetic process (GO:0045073)2.25881821
137modulation by symbiont of host cellular process (GO:0044068)2.25549830
138hepatocyte apoptotic process (GO:0097284)2.25255959
139embryonic process involved in female pregnancy (GO:0060136)2.24806363
140cellular response to virus (GO:0098586)2.24511296
141positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.22095052
142positive regulation of cellular amide metabolic process (GO:0034250)2.21966929
143granulocyte activation (GO:0036230)2.20559659
144negative regulation of toll-like receptor signaling pathway (GO:0034122)2.20323031
145negative regulation of granulocyte differentiation (GO:0030853)2.19556124
146negative regulation of type 2 immune response (GO:0002829)2.17203793
147adhesion of symbiont to host (GO:0044406)2.15797438
148mature B cell differentiation involved in immune response (GO:0002313)2.15566669
149positive regulation of transcription factor import into nucleus (GO:0042993)2.15200524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.82540879
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68568482
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.56030735
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.17002776
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.01513028
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.94939962
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72778176
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66816637
9VDR_21846776_ChIP-Seq_THP-1_Human2.64748192
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63598360
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61544966
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.43721761
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39641127
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.37655701
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37340973
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.37292717
17MYC_22102868_ChIP-Seq_BL_Human2.30950773
18* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25041104
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23988619
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19301131
21MAF_26560356_Chip-Seq_TH1_Human2.00318951
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.99731894
23* TCF7_22412390_ChIP-Seq_EML_Mouse1.94849041
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94002728
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.92900581
26E2F7_22180533_ChIP-Seq_HELA_Human1.90689262
27* VDR_24763502_ChIP-Seq_THP-1_Human1.90591296
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85763269
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85244723
30CLOCK_20551151_ChIP-Seq_293T_Human1.83282495
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.82715138
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81542087
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80404278
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77595840
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75901579
36SCL_19346495_ChIP-Seq_HPC-7_Human1.71141641
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69649589
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69287602
39KDM2B_26808549_Chip-Seq_DND41_Human1.68325021
40UTX_26944678_Chip-Seq_JUKART_Human1.67085929
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64184632
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64135439
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63225932
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60777551
45* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58987705
46* RXR_22158963_ChIP-Seq_LIVER_Mouse1.58789049
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58000318
48SPI1_23127762_ChIP-Seq_K562_Human1.57798603
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.56742908
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56213774
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55153200
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54662751
53* KDM2B_26808549_Chip-Seq_K562_Human1.54548537
54MYB_26560356_Chip-Seq_TH2_Human1.53995267
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49646116
56GATA1_22025678_ChIP-Seq_K562_Human1.46833794
57* SPI1_23547873_ChIP-Seq_NB4_Human1.44241750
58LXR_22292898_ChIP-Seq_THP-1_Human1.42443934
59MYB_26560356_Chip-Seq_TH1_Human1.41997137
60* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41578490
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.41032025
62* KDM2B_26808549_Chip-Seq_JURKAT_Human1.40080175
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39129224
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38150586
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34413559
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31672609
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30909697
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29289859
69RACK7_27058665_Chip-Seq_MCF-7_Human1.28669491
70ATF3_27146783_Chip-Seq_COLON_Human1.28157578
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26611823
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25596919
73* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24520515
74* MAF_26560356_Chip-Seq_TH2_Human1.24019781
75* PU_27001747_Chip-Seq_BMDM_Mouse1.23591786
76* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17866913
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.17432500
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17100395
79* TBX20_22080862_ChIP-Seq_HEART_Mouse1.16729145
80* TBX20_22328084_ChIP-Seq_HEART_Mouse1.16729145
81ZNF263_19887448_ChIP-Seq_K562_Human1.16542883
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14297712
83RUNX_20019798_ChIP-Seq_JUKART_Human1.14195136
84* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13368588
85* GATA1_19941826_ChIP-Seq_K562_Human1.13241672
86* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12385031
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11821440
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.11643747
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.09161202
90* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08514230
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08259348
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07750208
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07301675
94* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07136817
95* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05460065
96NCOR1_26117541_ChIP-Seq_K562_Human1.04949781
97TFEB_21752829_ChIP-Seq_HELA_Human1.04275573
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03655359
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02653412
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01858213
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01633528
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.01324581
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.00918955
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.00424076
105VDR_24787735_ChIP-Seq_THP-1_Human1.00204016
106GATA3_27048872_Chip-Seq_THYMUS_Human1.00150463
107* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99745939
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99587893
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98621246
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.96591699
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96092090
112CREB1_26743006_Chip-Seq_LNCaP_Human0.95641344
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95534646
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95452611
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94617717
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.94488890
117GATA6_25053715_ChIP-Seq_YYC3_Human0.92717456
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90687335
119* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90663081
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90302594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.46445236
2MP0005451_abnormal_body_composition3.19171102
3MP0003300_gastrointestinal_ulcer2.90399214
4MP0004510_myositis2.59225093
5MP0003436_decreased_susceptibility_to2.56793772
6MP0003705_abnormal_hypodermis_morpholog2.41625156
7MP0009278_abnormal_bone_marrow2.15987522
8MP0001835_abnormal_antigen_presentation2.14605600
9MP0003646_muscle_fatigue2.01770092
10MP0004084_abnormal_cardiac_muscle1.98902774
11MP0000685_abnormal_immune_system1.97646265
12* MP0009785_altered_susceptibility_to1.97583762
13MP0005058_abnormal_lysosome_morphology1.94729867
14MP0003566_abnormal_cell_adhesion1.90109019
15* MP0002419_abnormal_innate_immunity1.86950071
16MP0005387_immune_system_phenotype1.78881925
17MP0001790_abnormal_immune_system1.78881925
18MP0004947_skin_inflammation1.76083093
19* MP0005025_abnormal_response_to1.73478901
20MP0005000_abnormal_immune_tolerance1.71818543
21MP0010352_gastrointestinal_tract_polyps1.68195454
22MP0005076_abnormal_cell_differentiation1.66409142
23MP0002877_abnormal_melanocyte_morpholog1.64527819
24MP0002837_dystrophic_cardiac_calcinosis1.62821736
25* MP0000343_altered_response_to1.62123326
26MP0001800_abnormal_humoral_immune1.59338413
27* MP0002452_abnormal_antigen_presenting1.58154389
28MP0008438_abnormal_cutaneous_collagen1.56730756
29MP0006082_CNS_inflammation1.55350321
30MP0001533_abnormal_skeleton_physiology1.54654595
31MP0003724_increased_susceptibility_to1.54596149
32MP0003828_pulmonary_edema1.54299150
33MP0003191_abnormal_cellular_cholesterol1.53669563
34MP0000750_abnormal_muscle_regeneration1.52348366
35MP0005464_abnormal_platelet_physiology1.51990968
36MP0008260_abnormal_autophagy1.51634356
37MP0008004_abnormal_stomach_pH1.51188914
38MP0004130_abnormal_muscle_cell1.49813882
39MP0004087_abnormal_muscle_fiber1.45586924
40MP0000751_myopathy1.44520947
41MP0002148_abnormal_hypersensitivity_rea1.44258136
42MP0001853_heart_inflammation1.44074058
43* MP0002723_abnormal_immune_serum1.43735915
44MP0010630_abnormal_cardiac_muscle1.42997343
45MP0003448_altered_tumor_morphology1.39279528
46MP0002166_altered_tumor_susceptibility1.38448412
47MP0010307_abnormal_tumor_latency1.37597293
48MP0005330_cardiomyopathy1.33973177
49* MP0003221_abnormal_cardiomyocyte_apopto1.33482684
50MP0002405_respiratory_system_inflammati1.32127748
51MP0004808_abnormal_hematopoietic_stem1.31855705
52MP0004036_abnormal_muscle_relaxation1.31359459
53MP0002254_reproductive_system_inflammat1.31307591
54* MP0001819_abnormal_immune_cell1.30075967
55MP0003763_abnormal_thymus_physiology1.29949129
56* MP0002420_abnormal_adaptive_immunity1.29347329
57MP0001849_ear_inflammation1.26456373
58MP0002332_abnormal_exercise_endurance1.25918153
59MP0001545_abnormal_hematopoietic_system1.24605447
60MP0005397_hematopoietic_system_phenotyp1.24605447
61MP0005023_abnormal_wound_healing1.24155975
62* MP0001845_abnormal_inflammatory_respons1.24151583
63MP0000733_abnormal_muscle_development1.24095477
64MP0001958_emphysema1.22398532
65MP0004185_abnormal_adipocyte_glucose1.22386394
66* MP0010155_abnormal_intestine_physiology1.19293373
67* MP0008469_abnormal_protein_level1.17469605
68MP0003091_abnormal_cell_migration1.17261224
69MP0000749_muscle_degeneration1.16022929
70MP0003172_abnormal_lysosome_physiology1.15190398
71MP0009764_decreased_sensitivity_to1.13896321
72MP0005666_abnormal_adipose_tissue1.13184299
73MP0001544_abnormal_cardiovascular_syste1.12351354
74MP0005385_cardiovascular_system_phenoty1.12351354
75MP0004858_abnormal_nervous_system1.09115759
76MP0005166_decreased_susceptibility_to1.08909813
77MP0002106_abnormal_muscle_physiology1.08523344
78MP0000858_altered_metastatic_potential1.08017842
79MP0002398_abnormal_bone_marrow1.07988037
80* MP0009840_abnormal_foam_cell1.07892968
81MP0002972_abnormal_cardiac_muscle1.07125972
82MP0003279_aneurysm1.06144887
83MP0005671_abnormal_response_to1.05793209
84* MP0000716_abnormal_immune_system1.04605693
85MP0002006_tumorigenesis1.03968541
86MP0005375_adipose_tissue_phenotype1.02373979
87MP0000604_amyloidosis1.01540176
88MP0009333_abnormal_splenocyte_physiolog1.00499348
89MP0005083_abnormal_biliary_tract0.99678320
90MP0002998_abnormal_bone_remodeling0.98846121
91MP0008775_abnormal_heart_ventricle0.98362109
92MP0005390_skeleton_phenotype0.98346667
93MP0001873_stomach_inflammation0.97497028
94MP0003656_abnormal_erythrocyte_physiolo0.95747876
95MP0001851_eye_inflammation0.95696973
96* MP0000689_abnormal_spleen_morphology0.94965605
97MP0002933_joint_inflammation0.94813485
98MP0002138_abnormal_hepatobiliary_system0.94637738
99MP0000767_abnormal_smooth_muscle0.93845622
100MP0002396_abnormal_hematopoietic_system0.92522487
101MP0004233_abnormal_muscle_weight0.92386843
102* MP0002429_abnormal_blood_cell0.91969139
103MP0000609_abnormal_liver_physiology0.91499289
104MP0002722_abnormal_immune_system0.90483559
105MP0003075_altered_response_to0.89658014
106MP0003453_abnormal_keratinocyte_physiol0.88348654
107MP0009763_increased_sensitivity_to0.87755987
108MP0005164_abnormal_response_to0.87687875
109MP0010234_abnormal_vibrissa_follicle0.87386043
110MP0000249_abnormal_blood_vessel0.87025819
111MP0005257_abnormal_intraocular_pressure0.86235697
112MP0002796_impaired_skin_barrier0.85679313
113MP0005319_abnormal_enzyme/_coenzyme0.84936935
114MP0004215_abnormal_myocardial_fiber0.84906640
115MP0005310_abnormal_salivary_gland0.82354656
116MP0005409_darkened_coat_color0.82016945
117MP0005167_abnormal_blood-brain_barrier0.80985739
118MP0003795_abnormal_bone_structure0.79424906
119MP0000759_abnormal_skeletal_muscle0.79171701
120MP0000747_muscle_weakness0.78220240
121MP0001542_abnormal_bone_strength0.78201387
122MP0002269_muscular_atrophy0.78147105
123MP0005165_increased_susceptibility_to0.76631491

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.33733200
2Recurrent abscess formation (HP:0002722)3.79717064
3Recurrent bacterial skin infections (HP:0005406)3.52301762
4Exercise-induced muscle cramps (HP:0003710)3.44458977
5Abnormality of glycolipid metabolism (HP:0010969)3.42541434
6Abnormality of liposaccharide metabolism (HP:0010968)3.42541434
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.42541434
8Elevated erythrocyte sedimentation rate (HP:0003565)3.39600525
9Recurrent gram-negative bacterial infections (HP:0005420)3.24691110
10Asymmetric septal hypertrophy (HP:0001670)3.11242100
11Myositis (HP:0100614)2.97730396
12Ventricular tachycardia (HP:0004756)2.96403686
13Hematochezia (HP:0002573)2.95991235
14Interstitial pulmonary disease (HP:0006530)2.93507272
15Increased connective tissue (HP:0009025)2.93083326
16Distal lower limb muscle weakness (HP:0009053)2.87084225
17Abnormality of macrophages (HP:0004311)2.86559074
18Sudden death (HP:0001699)2.82053367
19Orchitis (HP:0100796)2.79081667
20Increased density of long bones (HP:0006392)2.76184460
21Abnormality of the left ventricular outflow tract (HP:0011103)2.73678712
22Subaortic stenosis (HP:0001682)2.73678712
23Muscle fiber splitting (HP:0003555)2.66675886
24Mediastinal lymphadenopathy (HP:0100721)2.66081344
25Distal lower limb amyotrophy (HP:0008944)2.65106584
26Increased cerebral lipofuscin (HP:0011813)2.63222733
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.63114441
28Hyporeflexia of lower limbs (HP:0002600)2.62201605
29Myoglobinuria (HP:0002913)2.60720716
30Frequent falls (HP:0002359)2.54113956
31Increased variability in muscle fiber diameter (HP:0003557)2.52906693
32Abnormality of skeletal muscle fiber size (HP:0012084)2.52459830
33Exercise-induced myalgia (HP:0003738)2.51801139
34Myocardial infarction (HP:0001658)2.50412078
35Loss of speech (HP:0002371)2.46998511
36Systemic lupus erythematosus (HP:0002725)2.46331122
37Peritonitis (HP:0002586)2.46263581
38Cellulitis (HP:0100658)2.45312927
39Stomatitis (HP:0010280)2.45170853
40Cerebral aneurysm (HP:0004944)2.44126416
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.39508880
42Osteolytic defects of the hand bones (HP:0009699)2.39508880
43Increased IgE level (HP:0003212)2.38761842
44Lipoatrophy (HP:0100578)2.35883152
45Autoimmune thrombocytopenia (HP:0001973)2.35776137
46Recurrent fungal infections (HP:0002841)2.35357748
47Right ventricular cardiomyopathy (HP:0011663)2.32138474
48Neoplasm of head and neck (HP:0012288)2.30625198
49Esophageal neoplasm (HP:0100751)2.30625198
50Arterial thrombosis (HP:0004420)2.28884629
51Spontaneous hematomas (HP:0007420)2.26396636
52Rhabdomyolysis (HP:0003201)2.25085817
53Thin bony cortex (HP:0002753)2.24503574
54Gingivitis (HP:0000230)2.22239544
55Premature rupture of membranes (HP:0001788)2.20697202
56Abnormality of the nasal mucosa (HP:0000433)2.18178468
57Difficulty running (HP:0009046)2.16720322
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15422953
59Abnormality of polysaccharide metabolism (HP:0011012)2.15422953
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15422953
61Recurrent skin infections (HP:0001581)2.14865564
62Urticaria (HP:0001025)2.14307035
63Tetraparesis (HP:0002273)2.13977101
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.13613124
65Urinary glycosaminoglycan excretion (HP:0003541)2.13445964
66Mucopolysacchariduria (HP:0008155)2.13445964
67Retrobulbar optic neuritis (HP:0100654)2.12216549
68Optic neuritis (HP:0100653)2.12216549
69Calf muscle hypertrophy (HP:0008981)2.12040821
70EMG: myopathic abnormalities (HP:0003458)2.11914707
71Axonal loss (HP:0003447)2.10270072
72Chronic otitis media (HP:0000389)2.09921746
73Recurrent viral infections (HP:0004429)2.08105579
74Persistence of primary teeth (HP:0006335)2.06852146
75Spondylolisthesis (HP:0003302)2.05242576
76Difficulty climbing stairs (HP:0003551)2.03517232
77Type 1 muscle fiber predominance (HP:0003803)2.02119363
78Achilles tendon contracture (HP:0001771)2.01709629
79Nausea (HP:0002018)2.01607027
80Gastrointestinal stroma tumor (HP:0100723)1.99405035
81Vasculitis (HP:0002633)1.98805107
82Malnutrition (HP:0004395)1.98286657
83Nasal polyposis (HP:0100582)1.97193472
84Nuclear cataract (HP:0100018)1.94976869
85Chest pain (HP:0100749)1.94209617
86Esophageal varix (HP:0002040)1.92988388
87Colitis (HP:0002583)1.92867560
88Mucosal telangiectasiae (HP:0100579)1.90846182
89Segmental peripheral demyelination/remyelination (HP:0003481)1.89554666
90Periodontitis (HP:0000704)1.88847949
91Long toe (HP:0010511)1.88812157
92Emphysema (HP:0002097)1.88611926
93Porencephaly (HP:0002132)1.88589452
94Limb-girdle muscle atrophy (HP:0003797)1.88391254
95Chronic obstructive pulmonary disease (HP:0006510)1.87568015
96Obstructive lung disease (HP:0006536)1.87568015
97Ulnar deviation of the wrist (HP:0003049)1.87405300
98Cervical subluxation (HP:0003308)1.87123201
99Osteomyelitis (HP:0002754)1.87061224
100Muscle hypertrophy of the lower extremities (HP:0008968)1.86879422
101Mildly elevated creatine phosphokinase (HP:0008180)1.85993970
102Conjunctival hamartoma (HP:0100780)1.84607747
103Abnormality of the calf musculature (HP:0001430)1.84414522
104Vacuolated lymphocytes (HP:0001922)1.84329264
105Gastrointestinal infarctions (HP:0005244)1.83986466
106Polycythemia (HP:0001901)1.83826587
107Purpura (HP:0000979)1.83581707
108Increased serum ferritin (HP:0003281)1.83315070
109Bulbar palsy (HP:0001283)1.83056681
110Vertebral compression fractures (HP:0002953)1.83047939
111Aneurysm (HP:0002617)1.82969615
112Dilatation of the ascending aorta (HP:0005111)1.82750032
113Neurofibrillary tangles (HP:0002185)1.81737008
114Muscle fiber inclusion bodies (HP:0100299)1.80607339
115Pulmonary infiltrates (HP:0002113)1.80283671
116Abnormality of the Achilles tendon (HP:0005109)1.79699437
117Dilated cardiomyopathy (HP:0001644)1.79218366
118Protrusio acetabuli (HP:0003179)1.78995866
119Inflammation of the large intestine (HP:0002037)1.78937527
120Abnormality of complement system (HP:0005339)1.77930100
121Gastrointestinal inflammation (HP:0004386)1.77861543
122Bone pain (HP:0002653)1.77225306
123Abnormal platelet function (HP:0011869)1.77067899
124Impaired platelet aggregation (HP:0003540)1.77067899
125Dysostosis multiplex (HP:0000943)1.76967736
126Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76689539
127Hemorrhage of the eye (HP:0011885)1.76320612
128Spinal rigidity (HP:0003306)1.75802048
129Broad face (HP:0000283)1.75541616
130Hepatosplenomegaly (HP:0001433)1.73868906
131Pustule (HP:0200039)1.73779991
132Polygenic inheritance (HP:0010982)1.73677538
133Ulnar bowing (HP:0003031)1.73578483
134Aortic aneurysm (HP:0004942)1.73431934
135Facial diplegia (HP:0001349)1.72454102
136Meningitis (HP:0001287)1.71635150
137Obstructive sleep apnea (HP:0002870)1.71490478
138Flat acetabular roof (HP:0003180)1.70920903
139Thrombocytosis (HP:0001894)1.70839174
140Amyloidosis (HP:0011034)1.70607112
141Cerebral inclusion bodies (HP:0100314)1.69914069
142Abnormality of the thoracic spine (HP:0100711)1.69813410
143Hyperparathyroidism (HP:0000843)1.69772854
144Myopathic facies (HP:0002058)1.69127649
145Thoracic kyphosis (HP:0002942)1.68446751
146Restrictive lung disease (HP:0002091)1.66781376
147Glomerulonephritis (HP:0000099)1.65648961
148Keratoconjunctivitis sicca (HP:0001097)1.64476108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.43524130
2TTN3.97498172
3PKN23.72797652
4PRPF4B3.58629083
5ERN13.00711064
6TBK12.76503858
7MAP4K12.40153772
8MAP3K102.39577541
9TYK22.25202954
10EPHB12.10502115
11PTK61.98969482
12EEF2K1.97996243
13TAOK21.97479929
14MAP3K141.81032673
15IRAK31.80410745
16LRRK21.79357790
17MAP2K31.76355229
18SMG11.74912928
19ICK1.73772830
20CDC42BPA1.69834619
21STK101.64239209
22JAK31.57290433
23RIPK11.56493800
24MAP3K131.53623787
25KIT1.43873903
26JAK11.42494353
27IKBKE1.40512688
28IRAK41.39270474
29BLK1.39200410
30DMPK1.35818921
31FGFR41.35674010
32ZAP701.34398336
33DDR21.33748759
34TGFBR21.32128945
35CDK61.29717804
36NEK91.24143407
37RPS6KA41.21505457
38SIK11.21030737
39CDK41.15154308
40TAOK31.13989928
41CSK1.13849771
42MAP3K51.13130250
43IKBKB1.12788351
44FLT31.11948137
45MOS1.11690952
46BMX1.10534432
47PAK41.07748086
48BTK1.06481504
49SIK31.06306813
50MAP3K61.05792310
51KSR21.05465093
52STK241.00695876
53STK31.00158259
54MAP3K31.00073145
55CAMK1D0.99774893
56HCK0.99727315
57OBSCN0.96797056
58IRAK20.95055369
59PRKD20.92817606
60STK40.92752793
61MARK20.92695436
62MAP3K110.90410016
63JAK20.90073869
64CHUK0.89070565
65CSF1R0.88384543
66CDK120.86584594
67GRK70.84236636
68PDGFRA0.83937837
69TESK10.83337406
70EPHA30.82949370
71ALK0.81743712
72FGFR30.81136524
73PDPK10.80579920
74RIPK40.80054809
75HIPK20.76707588
76IRAK10.76004323
77MAPK120.75657671
78LATS20.73871791
79NME20.72592416
80RPS6KC10.72374151
81RPS6KL10.72374151
82ARAF0.72358301
83PIM10.70972366
84BCKDK0.68997710
85RPS6KA20.68573154
86ILK0.67906663
87TRPM70.65589983
88ITK0.64793576
89MAPK70.64151960
90MAP3K80.63625676
91SCYL20.63406446
92KDR0.61403942
93TXK0.60913404
94LCK0.60405091
95SYK0.60343291
96LMTK20.60210079
97MAP3K70.59340583
98GRK60.58819995
99TESK20.57245973
100TAOK10.56361384
101MTOR0.56314318
102PDK10.56040940
103EGFR0.55708281
104RET0.55589504
105EPHA20.55138158
106MARK30.54337451
107PIM20.53962378
108CAMK1G0.52664503
109LATS10.50053562
110PDGFRB0.48762179
111PTK20.48206304
112DYRK1B0.47982003
113PRKG20.47481027
114MATK0.47176324
115BMPR20.46353959
116MAPK110.46029797
117FES0.44760943
118RPS6KA60.44597897
119CDK90.44112115
120MYLK0.43825697
121MAP3K10.43772884
122TGFBR10.43090123
123FGR0.43025017
124LYN0.42448806
125PRKD10.42270382
126TIE10.42154217
127TEC0.41849748
128PRKAA20.41840347
129MST1R0.40326124
130NEK20.40228693
131PAK20.39142673
132ABL10.38168320
133PIK3CG0.37805564

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.92439327
2Osteoclast differentiation_Homo sapiens_hsa043802.32367366
3Staphylococcus aureus infection_Homo sapiens_hsa051502.26057609
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06303838
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.01280715
6Legionellosis_Homo sapiens_hsa051341.98925865
7Malaria_Homo sapiens_hsa051441.88655343
8Toxoplasmosis_Homo sapiens_hsa051451.81478819
9Pertussis_Homo sapiens_hsa051331.78893782
10Viral myocarditis_Homo sapiens_hsa054161.77352725
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74411315
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74255102
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69722615
14TNF signaling pathway_Homo sapiens_hsa046681.69350432
15B cell receptor signaling pathway_Homo sapiens_hsa046621.66075325
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.60905039
17Tuberculosis_Homo sapiens_hsa051521.59274755
18Measles_Homo sapiens_hsa051621.53188960
19Chronic myeloid leukemia_Homo sapiens_hsa052201.50801231
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48635016
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47862706
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43239839
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42033133
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41949048
25Bladder cancer_Homo sapiens_hsa052191.39049665
26Influenza A_Homo sapiens_hsa051641.38101324
27Insulin resistance_Homo sapiens_hsa049311.36277336
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36239103
29Apoptosis_Homo sapiens_hsa042101.34938813
30Fatty acid degradation_Homo sapiens_hsa000711.32339112
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31644930
32Shigellosis_Homo sapiens_hsa051311.30572123
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.29467907
34Small cell lung cancer_Homo sapiens_hsa052221.27844710
35Amoebiasis_Homo sapiens_hsa051461.27647576
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24619833
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21000796
38Antigen processing and presentation_Homo sapiens_hsa046121.20940692
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.20343864
40Prion diseases_Homo sapiens_hsa050201.20326698
41Acute myeloid leukemia_Homo sapiens_hsa052211.19689396
42Salmonella infection_Homo sapiens_hsa051321.17563349
43Asthma_Homo sapiens_hsa053101.17235145
44Hepatitis B_Homo sapiens_hsa051611.15800998
45Autoimmune thyroid disease_Homo sapiens_hsa053201.15474884
46Dilated cardiomyopathy_Homo sapiens_hsa054141.12411282
47Herpes simplex infection_Homo sapiens_hsa051681.11648489
48Lysosome_Homo sapiens_hsa041421.10019956
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09141413
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.06757237
51Carbon metabolism_Homo sapiens_hsa012001.05339553
52Pancreatic cancer_Homo sapiens_hsa052121.02007444
53Focal adhesion_Homo sapiens_hsa045100.99213689
54Caffeine metabolism_Homo sapiens_hsa002320.99026060
55HIF-1 signaling pathway_Homo sapiens_hsa040660.95679862
56Hepatitis C_Homo sapiens_hsa051600.92437896
57Endometrial cancer_Homo sapiens_hsa052130.92390131
58Graft-versus-host disease_Homo sapiens_hsa053320.91729183
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88677529
60Hematopoietic cell lineage_Homo sapiens_hsa046400.88668535
61Proteoglycans in cancer_Homo sapiens_hsa052050.86755131
62Allograft rejection_Homo sapiens_hsa053300.86549414
63PPAR signaling pathway_Homo sapiens_hsa033200.82505104
64Platelet activation_Homo sapiens_hsa046110.81508692
65Lysine degradation_Homo sapiens_hsa003100.80912012
66Complement and coagulation cascades_Homo sapiens_hsa046100.80738600
67GnRH signaling pathway_Homo sapiens_hsa049120.80608797
68Arginine biosynthesis_Homo sapiens_hsa002200.80054531
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.79461719
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78952989
71Chemokine signaling pathway_Homo sapiens_hsa040620.78914226
72* Neurotrophin signaling pathway_Homo sapiens_hsa047220.78465763
73Phagosome_Homo sapiens_hsa041450.76801051
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.75691317
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.75563014
76Notch signaling pathway_Homo sapiens_hsa043300.74486625
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.74290357
78Other glycan degradation_Homo sapiens_hsa005110.74116402
79Fatty acid metabolism_Homo sapiens_hsa012120.72621719
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71255471
81Type I diabetes mellitus_Homo sapiens_hsa049400.70404480
82ErbB signaling pathway_Homo sapiens_hsa040120.70309668
83Prolactin signaling pathway_Homo sapiens_hsa049170.69609536
84* Viral carcinogenesis_Homo sapiens_hsa052030.68859089
85Prostate cancer_Homo sapiens_hsa052150.67813134
86Pentose phosphate pathway_Homo sapiens_hsa000300.67741622
87Type II diabetes mellitus_Homo sapiens_hsa049300.67268980
88HTLV-I infection_Homo sapiens_hsa051660.66816295
89Glioma_Homo sapiens_hsa052140.66498816
90T cell receptor signaling pathway_Homo sapiens_hsa046600.66483592
91Starch and sucrose metabolism_Homo sapiens_hsa005000.66427942
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66396771
93Fructose and mannose metabolism_Homo sapiens_hsa000510.66121413
94Endocytosis_Homo sapiens_hsa041440.65342203
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65079549
96Thyroid cancer_Homo sapiens_hsa052160.64791469
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64767330
98MicroRNAs in cancer_Homo sapiens_hsa052060.64739248
99Insulin signaling pathway_Homo sapiens_hsa049100.63631981
100FoxO signaling pathway_Homo sapiens_hsa040680.63546585
101Galactose metabolism_Homo sapiens_hsa000520.61529086
102Propanoate metabolism_Homo sapiens_hsa006400.61479218
103mTOR signaling pathway_Homo sapiens_hsa041500.61189027
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60333094
105ECM-receptor interaction_Homo sapiens_hsa045120.60145370
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56654816
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56506251
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55966965
109Non-small cell lung cancer_Homo sapiens_hsa052230.55236510
110* VEGF signaling pathway_Homo sapiens_hsa043700.55171933
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54889594
112Choline metabolism in cancer_Homo sapiens_hsa052310.54421786
113Rheumatoid arthritis_Homo sapiens_hsa053230.53250257
114Epstein-Barr virus infection_Homo sapiens_hsa051690.53043964
115Estrogen signaling pathway_Homo sapiens_hsa049150.51473252
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50654102
117Renal cell carcinoma_Homo sapiens_hsa052110.49479441
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48013974
119Primary immunodeficiency_Homo sapiens_hsa053400.47563254
120Adherens junction_Homo sapiens_hsa045200.46511780
121Biosynthesis of amino acids_Homo sapiens_hsa012300.46251950
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46023166
123African trypanosomiasis_Homo sapiens_hsa051430.45747720

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