MAPK8IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.27726984
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.90662337
3locomotory exploration behavior (GO:0035641)5.71390447
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51842394
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28601536
6vocalization behavior (GO:0071625)4.95654153
7synaptic vesicle exocytosis (GO:0016079)4.89535092
8regulation of synaptic vesicle exocytosis (GO:2000300)4.86768761
9glutamate secretion (GO:0014047)4.80429447
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79924399
11layer formation in cerebral cortex (GO:0021819)4.77155333
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.43885308
13regulation of glutamate receptor signaling pathway (GO:1900449)4.41278822
14regulation of synapse structural plasticity (GO:0051823)4.36222491
15dendritic spine morphogenesis (GO:0060997)4.33773439
16regulation of neuronal synaptic plasticity (GO:0048168)4.33521560
17protein localization to synapse (GO:0035418)4.30826817
18exploration behavior (GO:0035640)4.28772623
19neuronal action potential propagation (GO:0019227)4.25125406
20regulation of synaptic vesicle transport (GO:1902803)4.24747656
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24467706
22neuron cell-cell adhesion (GO:0007158)4.22135789
23neurotransmitter secretion (GO:0007269)4.22021111
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.12265341
25amino acid import (GO:0043090)4.09785322
26gamma-aminobutyric acid transport (GO:0015812)4.02912027
27glycine transport (GO:0015816)3.83644113
28cellular potassium ion homeostasis (GO:0030007)3.78522392
29synaptic transmission, glutamatergic (GO:0035249)3.77699592
30neuromuscular process controlling balance (GO:0050885)3.77380845
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.72961011
32sodium ion export (GO:0071436)3.72044497
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71141785
34proline transport (GO:0015824)3.67445150
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65188272
36neurotransmitter-gated ion channel clustering (GO:0072578)3.62752957
37auditory behavior (GO:0031223)3.57856072
38activation of protein kinase A activity (GO:0034199)3.57524693
39long-term memory (GO:0007616)3.57365460
40positive regulation of membrane potential (GO:0045838)3.57002531
41glutamate receptor signaling pathway (GO:0007215)3.56532351
42presynaptic membrane assembly (GO:0097105)3.56309275
43dendrite morphogenesis (GO:0048813)3.55850105
44neuron-neuron synaptic transmission (GO:0007270)3.54600382
45transmission of nerve impulse (GO:0019226)3.52793559
46regulation of dendritic spine morphogenesis (GO:0061001)3.48812826
47neuronal ion channel clustering (GO:0045161)3.47404456
48neuron recognition (GO:0008038)3.45700382
49regulation of synapse maturation (GO:0090128)3.44543561
50neurotransmitter transport (GO:0006836)3.43410072
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42466006
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39244671
53prepulse inhibition (GO:0060134)3.38467422
54cellular sodium ion homeostasis (GO:0006883)3.35050021
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.33385935
56response to auditory stimulus (GO:0010996)3.31899354
57regulation of synaptic plasticity (GO:0048167)3.31410738
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28685194
59axonal fasciculation (GO:0007413)3.27342187
60positive regulation of neurotransmitter secretion (GO:0001956)3.24222148
61regulation of postsynaptic membrane potential (GO:0060078)3.23709938
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23649522
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22387254
64regulation of neurotransmitter secretion (GO:0046928)3.21510159
65cerebellar Purkinje cell differentiation (GO:0021702)3.21201582
66positive regulation of synapse maturation (GO:0090129)3.18764813
67cell migration in hindbrain (GO:0021535)3.18622351
68regulation of neurotransmitter levels (GO:0001505)3.17507359
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16914498
70neuromuscular process controlling posture (GO:0050884)3.15652872
71negative regulation of dendrite morphogenesis (GO:0050774)3.14703495
72establishment of mitochondrion localization (GO:0051654)3.13141858
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.12380474
74vesicle transport along microtubule (GO:0047496)3.12129325
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11688954
76dendritic spine organization (GO:0097061)3.11104401
77L-amino acid import (GO:0043092)3.10071718
78synaptic vesicle endocytosis (GO:0048488)3.09897202
79cerebellar Purkinje cell layer development (GO:0021680)3.08321084
80mating behavior (GO:0007617)3.07064670
81cell communication by electrical coupling (GO:0010644)3.05976027
82postsynaptic membrane organization (GO:0001941)3.05481834
83neuromuscular synaptic transmission (GO:0007274)3.05298354
84regulation of synaptic transmission (GO:0050804)3.04634348
85adult walking behavior (GO:0007628)3.04073092
86regulation of neurotransmitter transport (GO:0051588)3.03900267
87acidic amino acid transport (GO:0015800)3.03704334
88axon ensheathment in central nervous system (GO:0032291)3.03702296
89central nervous system myelination (GO:0022010)3.03702296
90regulation of ARF protein signal transduction (GO:0032012)3.02210070
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.01976832
92G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01697060
93membrane hyperpolarization (GO:0060081)3.01302355
94regulation of vesicle fusion (GO:0031338)2.98605525
95neuromuscular process (GO:0050905)2.98514582
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97146124
97organelle transport along microtubule (GO:0072384)2.95586488
98positive regulation of dendritic spine development (GO:0060999)2.95228889
99long-term synaptic potentiation (GO:0060291)2.94793061
100cell differentiation in hindbrain (GO:0021533)2.93368315
101membrane depolarization during action potential (GO:0086010)2.92812764
102positive regulation of dendrite development (GO:1900006)2.92322362
103mechanosensory behavior (GO:0007638)2.92071474
104potassium ion import (GO:0010107)2.92036439
105regulation of dendritic spine development (GO:0060998)2.90018126
106neurotransmitter uptake (GO:0001504)2.89269773
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88919015
108axon cargo transport (GO:0008088)2.88678712
109synapse assembly (GO:0007416)2.87861392
110membrane depolarization (GO:0051899)2.87593181
111negative regulation of microtubule polymerization (GO:0031115)2.87202172
112cerebellar granule cell differentiation (GO:0021707)2.86779391
113positive regulation of neurotransmitter transport (GO:0051590)2.84720506
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82782100
115learning (GO:0007612)2.82543747
116potassium ion homeostasis (GO:0055075)2.82211764
117presynaptic membrane organization (GO:0097090)2.81912407
118synaptic transmission (GO:0007268)2.81061077
119regulation of voltage-gated calcium channel activity (GO:1901385)2.80210441
120innervation (GO:0060384)2.79651137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35857644
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02907647
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00302077
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00300957
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.82926454
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79631178
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79631178
8GBX2_23144817_ChIP-Seq_PC3_Human2.75718749
9DROSHA_22980978_ChIP-Seq_HELA_Human2.73781474
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.68746428
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68346658
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60426305
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58614392
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.52397143
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47075275
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46229816
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43754440
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.41746259
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39388073
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38266246
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37618465
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.27890283
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25148242
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24382720
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.18739274
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04000814
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02350060
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98571543
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98161454
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.81807583
31AR_21572438_ChIP-Seq_LNCaP_Human1.80998768
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65710134
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57475053
34KDM2B_26808549_Chip-Seq_K562_Human1.49628171
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45796471
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.45737977
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43106362
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41565423
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40614199
40LXR_22292898_ChIP-Seq_THP-1_Human1.34949819
41* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33664380
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33412746
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32144912
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30409404
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.29354793
46SMAD4_21799915_ChIP-Seq_A2780_Human1.28258124
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28060164
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27691248
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23968010
50ZNF274_21170338_ChIP-Seq_K562_Hela1.23759706
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22381725
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.20623694
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19915716
54AR_19668381_ChIP-Seq_PC3_Human1.18589846
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18473808
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18270428
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.17840800
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16639641
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15909783
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.15609523
61* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14637737
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14302370
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10068211
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08910114
65* SMC4_20622854_ChIP-Seq_HELA_Human1.08218341
66STAT3_23295773_ChIP-Seq_U87_Human1.08127831
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.07741335
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.07165392
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07112245
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06745758
71CTCF_27219007_Chip-Seq_Bcells_Human1.03166994
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03091220
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02285105
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.02141626
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01854122
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.01545968
77OCT4_19829295_ChIP-Seq_ESCs_Human1.00974611
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00819519
79TAF15_26573619_Chip-Seq_HEK293_Human1.00438251
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99972129
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99073217
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96909137
83* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96567342
84AHR_22903824_ChIP-Seq_MCF-7_Human0.95473334
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95326253
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.95160300
87* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94605867
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93911468
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.93899214
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93316849
91TRIM28_21343339_ChIP-Seq_HEK293_Human0.93061238
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92561579
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92490891
94CREB1_26743006_Chip-Seq_LNCaP_Human0.92489316
95AR_25329375_ChIP-Seq_VCAP_Human0.92351387
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91248458
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90987716
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90705821
99TCF4_23295773_ChIP-Seq_U87_Human0.90384036
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88834785
101DPY_21335234_ChIP-Seq_ESCs_Mouse0.88557726
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87566211
103P300_19829295_ChIP-Seq_ESCs_Human0.86052560
104* P68_20966046_ChIP-Seq_HELA_Human0.86039100
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85765411
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85506841
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.85018947
108RNF2_27304074_Chip-Seq_NSC_Mouse0.84665798
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.84564556
110KLF4_19829295_ChIP-Seq_ESCs_Human0.84175209
111KDM2B_26808549_Chip-Seq_DND41_Human0.83718416
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83515658
113RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82025653
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81957524
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81478677
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.80983471
117* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79385842
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79257294
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79108649
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78641433
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.78375308
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77956094
123* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77699701
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77396494
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77101076
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75561977
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75420462
128* SMAD4_21741376_ChIP-Seq_ESCs_Human0.74806769
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72926483
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72181567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.43751777
2MP0003880_abnormal_central_pattern4.26394606
3* MP0003635_abnormal_synaptic_transmissio4.00335577
4MP0004270_analgesia4.00150152
5MP0009745_abnormal_behavioral_response3.21040242
6MP0002063_abnormal_learning/memory/cond3.17975293
7MP0005423_abnormal_somatic_nervous3.06925717
8MP0002064_seizures3.02708435
9MP0002822_catalepsy2.96167105
10MP0009046_muscle_twitch2.89466519
11MP0002734_abnormal_mechanical_nocicepti2.74978361
12MP0001968_abnormal_touch/_nociception2.72106962
13MP0002272_abnormal_nervous_system2.61666202
14MP0001486_abnormal_startle_reflex2.60536734
15MP0002572_abnormal_emotion/affect_behav2.56405576
16MP0003329_amyloid_beta_deposits2.17552823
17MP0002733_abnormal_thermal_nociception2.13466699
18MP0009780_abnormal_chondrocyte_physiolo2.11124639
19MP0004858_abnormal_nervous_system2.10828604
20MP0000778_abnormal_nervous_system2.06747497
21MP0002735_abnormal_chemical_nociception2.02907424
22MP0001970_abnormal_pain_threshold2.01402996
23MP0004885_abnormal_endolymph2.01204357
24MP0008569_lethality_at_weaning2.00593514
25MP0002909_abnormal_adrenal_gland1.93490002
26MP0001440_abnormal_grooming_behavior1.91412027
27MP0002736_abnormal_nociception_after1.90777343
28MP0001501_abnormal_sleep_pattern1.86656505
29MP0000955_abnormal_spinal_cord1.85673262
30MP0002067_abnormal_sensory_capabilities1.84481306
31* MP0004811_abnormal_neuron_physiology1.84189061
32MP0002184_abnormal_innervation1.82136137
33MP0002557_abnormal_social/conspecific_i1.70405619
34MP0004924_abnormal_behavior1.65723641
35MP0005386_behavior/neurological_phenoty1.65723641
36MP0000920_abnormal_myelination1.64854908
37MP0003123_paternal_imprinting1.57450025
38MP0003283_abnormal_digestive_organ1.54373489
39* MP0002882_abnormal_neuron_morphology1.53231781
40* MP0002066_abnormal_motor_capabilities/c1.47657608
41MP0003633_abnormal_nervous_system1.45967177
42MP0001984_abnormal_olfaction1.40686701
43MP0003879_abnormal_hair_cell1.38435997
44MP0005646_abnormal_pituitary_gland1.38095287
45MP0004142_abnormal_muscle_tone1.29778856
46MP0003634_abnormal_glial_cell1.29159798
47MP0003690_abnormal_glial_cell1.28663830
48MP0001529_abnormal_vocalization1.28054977
49MP0006276_abnormal_autonomic_nervous1.27613731
50MP0003631_nervous_system_phenotype1.26418070
51MP0005645_abnormal_hypothalamus_physiol1.24146099
52MP0003787_abnormal_imprinting1.22011919
53* MP0002152_abnormal_brain_morphology1.19351179
54MP0001502_abnormal_circadian_rhythm1.17747265
55MP0002229_neurodegeneration1.14086672
56MP0001905_abnormal_dopamine_level1.12370136
57MP0004742_abnormal_vestibular_system1.08924343
58MP0002638_abnormal_pupillary_reflex1.07329583
59MP0003632_abnormal_nervous_system1.04362657
60MP0003122_maternal_imprinting1.01350166
61MP0005623_abnormal_meninges_morphology1.01229902
62MP0008961_abnormal_basal_metabolism0.99946466
63MP0001177_atelectasis0.99268321
64MP0004145_abnormal_muscle_electrophysio0.96690054
65MP0000013_abnormal_adipose_tissue0.95275122
66MP0001485_abnormal_pinna_reflex0.92418901
67MP0000604_amyloidosis0.92327204
68MP0001299_abnormal_eye_distance/0.91186604
69MP0000751_myopathy0.89309347
70* MP0002069_abnormal_eating/drinking_beha0.89117484
71MP0001346_abnormal_lacrimal_gland0.87553722
72MP0000569_abnormal_digit_pigmentation0.86300337
73MP0002752_abnormal_somatic_nervous0.85438930
74MP0000566_synostosis0.85123419
75MP0004043_abnormal_pH_regulation0.84376306
76MP0005394_taste/olfaction_phenotype0.83629330
77MP0005499_abnormal_olfactory_system0.83629330
78MP0000631_abnormal_neuroendocrine_gland0.81379922
79MP0005551_abnormal_eye_electrophysiolog0.81350537
80MP0001963_abnormal_hearing_physiology0.79182986
81MP0005167_abnormal_blood-brain_barrier0.78771907
82MP0002249_abnormal_larynx_morphology0.78568341
83MP0008872_abnormal_physiological_respon0.78482146
84MP0003121_genomic_imprinting0.77761176
85MP0004085_abnormal_heartbeat0.76579456
86MP0002090_abnormal_vision0.75631110
87MP0003137_abnormal_impulse_conducting0.75294202
88MP0000579_abnormal_nail_morphology0.75095654
89MP0001348_abnormal_lacrimal_gland0.73660397
90MP0003861_abnormal_nervous_system0.71207348
91MP0000026_abnormal_inner_ear0.70843227
92MP0005409_darkened_coat_color0.66117708
93MP0005535_abnormal_body_temperature0.65814939
94MP0002653_abnormal_ependyma_morphology0.65337924
95MP0003172_abnormal_lysosome_physiology0.65008366
96MP0000747_muscle_weakness0.64875205
97* MP0008874_decreased_physiological_sensi0.64871716
98MP0004233_abnormal_muscle_weight0.64681329
99MP0003938_abnormal_ear_development0.61717343
100MP0001943_abnormal_respiration0.60561380
101MP0005187_abnormal_penis_morphology0.59858478
102MP0004133_heterotaxia0.59791048
103MP0001986_abnormal_taste_sensitivity0.59306994
104MP0001188_hyperpigmentation0.58818283
105* MP0010770_preweaning_lethality0.58236044
106* MP0002082_postnatal_lethality0.58236044
107MP0005171_absent_coat_pigmentation0.58147563
108* MP0003075_altered_response_to0.58059125
109* MP0010768_mortality/aging0.57563316
110MP0010234_abnormal_vibrissa_follicle0.56477323
111MP0004130_abnormal_muscle_cell0.56238433
112MP0000534_abnormal_ureter_morphology0.55719377
113* MP0010769_abnormal_survival0.54376776
114MP0006072_abnormal_retinal_apoptosis0.54160451
115MP0002089_abnormal_postnatal_growth/wei0.52878541
116MP0010386_abnormal_urinary_bladder0.52561824
117MP0009379_abnormal_foot_pigmentation0.51918385
118* MP0003956_abnormal_body_size0.50454158

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.91721305
2Focal motor seizures (HP:0011153)5.69896515
3Focal seizures (HP:0007359)4.82426094
4Visual hallucinations (HP:0002367)4.67555703
5Action tremor (HP:0002345)4.51520027
6Supranuclear gaze palsy (HP:0000605)4.37584329
7Ankle clonus (HP:0011448)4.26027484
8Progressive cerebellar ataxia (HP:0002073)3.71682715
9Epileptic encephalopathy (HP:0200134)3.70141565
10Neurofibrillary tangles (HP:0002185)3.44266440
11Atonic seizures (HP:0010819)3.44217164
12Termporal pattern (HP:0011008)3.30377833
13Insidious onset (HP:0003587)3.30377833
14Mutism (HP:0002300)3.22695229
15Depression (HP:0000716)3.20460517
16Absence seizures (HP:0002121)3.15329842
17Spastic gait (HP:0002064)3.13075146
18Dysmetria (HP:0001310)3.11870429
19Impaired vibration sensation in the lower limbs (HP:0002166)3.11382177
20Generalized tonic-clonic seizures (HP:0002069)3.10510467
21Urinary bladder sphincter dysfunction (HP:0002839)3.10202657
22Cerebral inclusion bodies (HP:0100314)3.08498421
23Papilledema (HP:0001085)3.06665598
24Poor eye contact (HP:0000817)3.03461146
25Abnormality of the corticospinal tract (HP:0002492)3.03452709
26Megalencephaly (HP:0001355)3.02934509
27Febrile seizures (HP:0002373)3.02437523
28Intention tremor (HP:0002080)3.00317979
29Urinary urgency (HP:0000012)2.95948214
30Postural instability (HP:0002172)2.95678313
31Torticollis (HP:0000473)2.95592829
32Broad-based gait (HP:0002136)2.92726035
33Sleep apnea (HP:0010535)2.91931566
34Cerebral hypomyelination (HP:0006808)2.91194088
35Dysdiadochokinesis (HP:0002075)2.90844935
36Dialeptic seizures (HP:0011146)2.90501972
37Anxiety (HP:0000739)2.85334121
38Insomnia (HP:0100785)2.81068122
39Gaze-evoked nystagmus (HP:0000640)2.77297625
40Impaired social interactions (HP:0000735)2.76046433
41Abnormal social behavior (HP:0012433)2.76046433
42Abnormal eating behavior (HP:0100738)2.73799520
43Truncal ataxia (HP:0002078)2.69549488
44Scanning speech (HP:0002168)2.65775135
45Tetraplegia (HP:0002445)2.65434712
46Abnormality of the lower motor neuron (HP:0002366)2.64752061
47Focal dystonia (HP:0004373)2.60312802
48Genetic anticipation (HP:0003743)2.57311090
49Limb dystonia (HP:0002451)2.56247568
50Lower limb muscle weakness (HP:0007340)2.52436411
51Peripheral hypomyelination (HP:0007182)2.50775537
52Hemiparesis (HP:0001269)2.47511368
53Polyphagia (HP:0002591)2.44185008
54Craniofacial dystonia (HP:0012179)2.42450666
55Pheochromocytoma (HP:0002666)2.42142181
56Amblyopia (HP:0000646)2.40985418
57Ventricular fibrillation (HP:0001663)2.39842574
58Clonus (HP:0002169)2.39222193
59Turricephaly (HP:0000262)2.38507547
60Status epilepticus (HP:0002133)2.33770035
61Spastic tetraparesis (HP:0001285)2.30043534
62Hemiplegia (HP:0002301)2.29739732
63Annular pancreas (HP:0001734)2.28572219
64Impaired smooth pursuit (HP:0007772)2.27214330
65Delusions (HP:0000746)2.25013751
66Bradykinesia (HP:0002067)2.24950614
67Pointed chin (HP:0000307)2.24689810
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23513015
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.23513015
70Excessive salivation (HP:0003781)2.22781517
71Drooling (HP:0002307)2.22781517
72Diplopia (HP:0000651)2.21892540
73Abnormality of binocular vision (HP:0011514)2.21892540
74Onion bulb formation (HP:0003383)2.21682100
75Stereotypic behavior (HP:0000733)2.20869494
76Progressive inability to walk (HP:0002505)2.18950953
77Amyotrophic lateral sclerosis (HP:0007354)2.18418927
78Bronchomalacia (HP:0002780)2.15482444
79Split foot (HP:0001839)2.11434965
80Neuronal loss in central nervous system (HP:0002529)2.11115474
81Akinesia (HP:0002304)2.10876983
82Agitation (HP:0000713)2.08837133
83EEG with generalized epileptiform discharges (HP:0011198)2.06909782
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05101845
85Hypsarrhythmia (HP:0002521)2.05092142
86Epileptiform EEG discharges (HP:0011182)2.05051047
87Diminished motivation (HP:0000745)2.03496786
88Abnormality of ocular smooth pursuit (HP:0000617)2.02685302
89Bundle branch block (HP:0011710)2.02279957
90Increased circulating renin level (HP:0000848)2.00718666
91Obstructive sleep apnea (HP:0002870)1.99917466
92Fetal akinesia sequence (HP:0001989)1.98501756
93Impaired vibratory sensation (HP:0002495)1.97315309
94Neuroendocrine neoplasm (HP:0100634)1.97185478
95Hammertoe (HP:0001765)1.96471531
96Apathy (HP:0000741)1.96392746
97Overriding aorta (HP:0002623)1.96245784
98Postural tremor (HP:0002174)1.91961168
99Aplasia involving bones of the upper limbs (HP:0009823)1.91206650
100Aplasia of the phalanges of the hand (HP:0009802)1.91206650
101Aplasia involving bones of the extremities (HP:0009825)1.91206650
102Hyperacusis (HP:0010780)1.90278629
103Resting tremor (HP:0002322)1.89173635
104Hyperventilation (HP:0002883)1.88400580
105Ankyloglossia (HP:0010296)1.86421242
106Morphological abnormality of the pyramidal tract (HP:0002062)1.86274466
107Rigidity (HP:0002063)1.85942856
108Abnormality of saccadic eye movements (HP:0000570)1.85631732
109Rapidly progressive (HP:0003678)1.85014978
110Hand muscle atrophy (HP:0009130)1.84863795
111Choreoathetosis (HP:0001266)1.83766503
112Lower limb asymmetry (HP:0100559)1.83097639
113CNS hypomyelination (HP:0003429)1.81491328
114Lower limb amyotrophy (HP:0007210)1.81355304
115Gait ataxia (HP:0002066)1.81315579
116Neoplasm of the peripheral nervous system (HP:0100007)1.79946156
117Dysmetric saccades (HP:0000641)1.79496081
118Incomplete penetrance (HP:0003829)1.76945930
119Distal upper limb amyotrophy (HP:0007149)1.74453765
120Upper limb amyotrophy (HP:0009129)1.74453765
121Hyperthyroidism (HP:0000836)1.71224421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.93175118
2EPHA43.83218770
3NTRK33.75752297
4MARK13.73878213
5PRKD32.63873676
6MINK12.63611225
7PAK62.61423637
8MAP3K42.44200869
9NTRK12.41927992
10KSR22.37588552
11DAPK22.32212304
12NTRK22.14243372
13CAMKK12.06580707
14MAP2K71.67664871
15UHMK11.64967503
16CDK51.62629877
17TYRO31.59688319
18KSR11.51509267
19MAP3K21.49828950
20PHKG11.42665492
21PHKG21.42665492
22MAP2K41.37365998
23CDK191.32926035
24STK381.22398290
25TNIK1.21057513
26MAPK131.17861368
27OXSR11.15355218
28PRPF4B1.14037423
29PNCK1.12064283
30TAOK11.11866014
31LATS21.11295978
32SIK21.09066205
33GRK51.08908484
34STK391.08354968
35ALK1.08144199
36SGK2231.08098789
37SGK4941.08098789
38PRKCH1.07701352
39RET1.06107208
40CAMKK21.04914538
41PRKCG1.04095873
42CDK151.03618040
43CDK141.03140077
44STK111.03137630
45LMTK21.01803121
46CDK181.01651687
47MARK21.00946513
48ARAF1.00665605
49WNK10.97165456
50RIPK40.97163227
51FES0.94451231
52CSNK1G20.94186196
53PAK30.93813869
54DAPK10.93797972
55CDK11A0.91080499
56PLK20.90772108
57RIPK10.89672001
58ICK0.85736895
59CAMK2B0.83116907
60PINK10.81331737
61LIMK10.80731866
62MAPK150.80114593
63CAMK2A0.79752999
64MAP3K120.78947626
65CAMK10.77966486
66MAP3K130.75129030
67FGFR20.74426257
68MAPK120.73845516
69TESK10.73113541
70PKN10.72620960
71BRAF0.68834512
72SCYL20.68251499
73PDPK10.67220648
74NEK60.65912257
75WNK40.64685505
76MAP3K10.62794376
77DYRK1A0.62537938
78PDK10.61657547
79CDC42BPA0.60602522
80SGK10.59765573
81CAMK1G0.58974168
82PRKCZ0.58524714
83DYRK20.57140686
84FYN0.56072948
85CAMK40.54218882
86ROCK20.54152679
87SGK30.53864838
88DDR20.53842243
89CAMK2D0.53679498
90CASK0.52885247
91RAF10.52271144
92CAMK2G0.52163493
93BCR0.51181716
94RPS6KA30.50115004
95ERBB20.49935412
96CSNK1G30.49598721
97CSNK1A1L0.49093690
98TNK20.47287685
99NEK10.46815293
100BRSK10.46551562
101CAMK1D0.46276009
102ROCK10.45951824
103MAP3K110.44167506
104TRIB30.44039615
105PRKCE0.42631897
106PDGFRA0.42028162
107* MAPK100.40906933
108DAPK30.40792033
109SGK20.40733396
110MAPKAPK50.40676125
111PTK2B0.40611924
112RPS6KA20.37677424
113PRKG20.29777475
114CSNK1E0.29140695
115PRKG10.28367929
116* MAPK80.27938450
117PRKCA0.27860078

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.07230073
2Nicotine addiction_Homo sapiens_hsa050332.93604112
3Olfactory transduction_Homo sapiens_hsa047402.73455676
4GABAergic synapse_Homo sapiens_hsa047272.62292315
5Circadian entrainment_Homo sapiens_hsa047132.55694539
6Glutamatergic synapse_Homo sapiens_hsa047242.48213700
7Long-term potentiation_Homo sapiens_hsa047202.38533690
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36954060
9Morphine addiction_Homo sapiens_hsa050322.34595503
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32232231
11Amphetamine addiction_Homo sapiens_hsa050312.22510280
12Dopaminergic synapse_Homo sapiens_hsa047282.12744595
13Salivary secretion_Homo sapiens_hsa049702.02523720
14Insulin secretion_Homo sapiens_hsa049111.98522519
15Cholinergic synapse_Homo sapiens_hsa047251.95817612
16Gastric acid secretion_Homo sapiens_hsa049711.90132672
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80053813
18Cocaine addiction_Homo sapiens_hsa050301.79546124
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75529964
20Nitrogen metabolism_Homo sapiens_hsa009101.74052639
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72004908
22Long-term depression_Homo sapiens_hsa047301.64874986
23Vitamin B6 metabolism_Homo sapiens_hsa007501.62755659
24Renin secretion_Homo sapiens_hsa049241.53479786
25Oxytocin signaling pathway_Homo sapiens_hsa049211.53332945
26Taste transduction_Homo sapiens_hsa047421.50871870
27Serotonergic synapse_Homo sapiens_hsa047261.47698118
28Gap junction_Homo sapiens_hsa045401.47080211
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44100307
30GnRH signaling pathway_Homo sapiens_hsa049121.41717269
31Axon guidance_Homo sapiens_hsa043601.38644712
32Calcium signaling pathway_Homo sapiens_hsa040201.32405472
33Type II diabetes mellitus_Homo sapiens_hsa049301.30258878
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24784256
35cAMP signaling pathway_Homo sapiens_hsa040241.24045334
36Estrogen signaling pathway_Homo sapiens_hsa049151.23773477
37Glioma_Homo sapiens_hsa052141.20961068
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18912534
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13364295
40ErbB signaling pathway_Homo sapiens_hsa040121.11308495
41Melanogenesis_Homo sapiens_hsa049161.10558552
42Dorso-ventral axis formation_Homo sapiens_hsa043201.03510180
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02486843
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.01952878
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98028008
46Collecting duct acid secretion_Homo sapiens_hsa049660.93998306
47Pancreatic secretion_Homo sapiens_hsa049720.92690675
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92183323
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91813260
50Oocyte meiosis_Homo sapiens_hsa041140.89149684
51Thyroid hormone synthesis_Homo sapiens_hsa049180.84049104
52Vibrio cholerae infection_Homo sapiens_hsa051100.78139056
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76972629
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.76306618
55Cardiac muscle contraction_Homo sapiens_hsa042600.76120116
56Choline metabolism in cancer_Homo sapiens_hsa052310.75698027
57Endocytosis_Homo sapiens_hsa041440.73789920
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72528350
59Renal cell carcinoma_Homo sapiens_hsa052110.71508518
60Dilated cardiomyopathy_Homo sapiens_hsa054140.70747848
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.70151490
62VEGF signaling pathway_Homo sapiens_hsa043700.69266348
63Alcoholism_Homo sapiens_hsa050340.67306358
64* MAPK signaling pathway_Homo sapiens_hsa040100.66796550
65Phototransduction_Homo sapiens_hsa047440.65311553
66Ras signaling pathway_Homo sapiens_hsa040140.65248308
67Histidine metabolism_Homo sapiens_hsa003400.64943588
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64035553
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63736305
70Endometrial cancer_Homo sapiens_hsa052130.63629672
71mTOR signaling pathway_Homo sapiens_hsa041500.63590580
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62494829
73Rap1 signaling pathway_Homo sapiens_hsa040150.61829888
74Bile secretion_Homo sapiens_hsa049760.61096927
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60468703
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59721558
77Arginine and proline metabolism_Homo sapiens_hsa003300.55856858
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55436308
79Non-small cell lung cancer_Homo sapiens_hsa052230.55171746
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54385228
81Prion diseases_Homo sapiens_hsa050200.53179389
82beta-Alanine metabolism_Homo sapiens_hsa004100.52730449
83Hippo signaling pathway_Homo sapiens_hsa043900.51609935
84Inositol phosphate metabolism_Homo sapiens_hsa005620.50701787
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50115705
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49077546
87Wnt signaling pathway_Homo sapiens_hsa043100.47682541
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47466181
89Tight junction_Homo sapiens_hsa045300.46544358
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45756486
91Glucagon signaling pathway_Homo sapiens_hsa049220.45666382
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45180878
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44607047
94Insulin signaling pathway_Homo sapiens_hsa049100.44198863
95Ovarian steroidogenesis_Homo sapiens_hsa049130.42782680
96Type I diabetes mellitus_Homo sapiens_hsa049400.41748996
97Circadian rhythm_Homo sapiens_hsa047100.41262275
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40965584
99AMPK signaling pathway_Homo sapiens_hsa041520.40212400
100Chemokine signaling pathway_Homo sapiens_hsa040620.40207189
101Hedgehog signaling pathway_Homo sapiens_hsa043400.39132679
102Fatty acid biosynthesis_Homo sapiens_hsa000610.37326380
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37145797
104Arginine biosynthesis_Homo sapiens_hsa002200.32892105
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32495358
106Colorectal cancer_Homo sapiens_hsa052100.32276590
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31910666
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31215416
109Butanoate metabolism_Homo sapiens_hsa006500.30388653
110Notch signaling pathway_Homo sapiens_hsa043300.30182737
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.29817011
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29498914
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28531053

Most similar genes based on co-expression Upload to Enrichr

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