MAPK6PS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)8.48567937
2protein K11-linked deubiquitination (GO:0035871)6.28473147
3nuclear pore complex assembly (GO:0051292)5.66068662
4positive regulation of digestive system process (GO:0060456)5.27074867
5nuclear pore organization (GO:0006999)5.08086257
6negative regulation of smooth muscle cell differentiation (GO:0051151)4.61427929
7positive regulation of protein autophosphorylation (GO:0031954)4.61014374
8adaptation of signaling pathway (GO:0023058)4.44966194
9establishment of protein localization to Golgi (GO:0072600)4.30605620
10response to histamine (GO:0034776)4.25712273
11pore complex assembly (GO:0046931)4.22581954
12inner ear receptor cell development (GO:0060119)4.21159003
13negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.05051617
14nephron tubule formation (GO:0072079)4.02927520
15cochlea development (GO:0090102)3.83039985
16regulation of mesenchymal cell apoptotic process (GO:2001053)3.76059769
17negative regulation of systemic arterial blood pressure (GO:0003085)3.72097775
18Rap protein signal transduction (GO:0032486)3.69684092
19protein targeting to Golgi (GO:0000042)3.66291419
20retinal cone cell development (GO:0046549)3.64465438
21keratinocyte development (GO:0003334)3.60989933
22neural tube formation (GO:0001841)3.59485447
23innervation (GO:0060384)3.56414708
24ncRNA 3-end processing (GO:0043628)3.55563885
25retrograde transport, vesicle recycling within Golgi (GO:0000301)3.55324652
26negative regulation of oligodendrocyte differentiation (GO:0048715)3.54353861
27protein localization to microtubule cytoskeleton (GO:0072698)3.49247942
28regulation of DNA endoreduplication (GO:0032875)3.48029098
29keratinization (GO:0031424)3.48006693
30retinal rod cell development (GO:0046548)3.46711380
31DNA integration (GO:0015074)3.46223288
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.45539875
33negative regulation of dendrite morphogenesis (GO:0050774)3.43971669
34protein localization to cytoskeleton (GO:0044380)3.33435665
35negative regulation of B cell proliferation (GO:0030889)3.30698632
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.30003311
37regulation of translation, ncRNA-mediated (GO:0045974)3.30003311
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30003311
39brain morphogenesis (GO:0048854)3.27489049
40regulation of germinal center formation (GO:0002634)3.25096782
41flavonoid metabolic process (GO:0009812)3.24586881
42cytoplasmic mRNA processing body assembly (GO:0033962)3.21390723
43microtubule anchoring (GO:0034453)3.15191735
44photoreceptor cell maintenance (GO:0045494)3.14937395
45single strand break repair (GO:0000012)3.13864373
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13098976
47regulation of hippo signaling (GO:0035330)3.12176072
48regulation of type B pancreatic cell apoptotic process (GO:2000674)3.10699183
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04008589
50regulation of protein autophosphorylation (GO:0031952)3.03643631
51negative regulation of astrocyte differentiation (GO:0048712)3.02853428
52pericardium development (GO:0060039)3.00902102
53positive regulation of developmental pigmentation (GO:0048087)2.98022655
54Sertoli cell development (GO:0060009)2.96977964
55response to pheromone (GO:0019236)2.96493988
56positive regulation by host of viral transcription (GO:0043923)2.94590509
57histone mRNA catabolic process (GO:0071044)2.92195945
58protein prenylation (GO:0018342)2.91824054
59prenylation (GO:0097354)2.91824054
60detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.91297508
61limb development (GO:0060173)2.88944816
62appendage development (GO:0048736)2.88944816
63protein localization to Golgi apparatus (GO:0034067)2.85354391
64protein K48-linked deubiquitination (GO:0071108)2.83580478
65negative regulation of neurological system process (GO:0031645)2.80627531
66embryonic epithelial tube formation (GO:0001838)2.79503974
67tryptophan catabolic process (GO:0006569)2.79041522
68indole-containing compound catabolic process (GO:0042436)2.79041522
69indolalkylamine catabolic process (GO:0046218)2.79041522
70regulation of oligodendrocyte differentiation (GO:0048713)2.73980676
71cellular biogenic amine catabolic process (GO:0042402)2.70398466
72amine catabolic process (GO:0009310)2.70398466
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69724319
74snRNA transcription (GO:0009301)2.68528351
75monoubiquitinated protein deubiquitination (GO:0035520)2.66439698
76pyrimidine dimer repair (GO:0006290)2.64058896
77sympathetic nervous system development (GO:0048485)2.63462287
78epithelial tube formation (GO:0072175)2.62672386
79regulation of pigment cell differentiation (GO:0050932)2.61590380
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60940485
81olfactory bulb development (GO:0021772)2.59873506
82metanephric mesenchyme development (GO:0072075)2.58936933
83cell differentiation involved in metanephros development (GO:0072202)2.57456707
84cilium or flagellum-dependent cell motility (GO:0001539)2.56460641
85cellular response to ethanol (GO:0071361)2.53696179
86cranial nerve structural organization (GO:0021604)2.53253292
87lateral ventricle development (GO:0021670)2.52052653
88kynurenine metabolic process (GO:0070189)2.51757121
89pancreas development (GO:0031016)2.51275027
90magnesium ion transport (GO:0015693)2.51239989
91cellular response to ammonium ion (GO:0071242)2.50328905
92regulation of Rac protein signal transduction (GO:0035020)2.50018392
93cAMP catabolic process (GO:0006198)2.49162146
94regulation of acrosome reaction (GO:0060046)2.48755581
95regulation of dendritic spine morphogenesis (GO:0061001)2.48085000
96negative regulation of dendrite development (GO:2000171)2.45138558
97positive regulation of glycoprotein biosynthetic process (GO:0010560)2.43821370
98intestinal epithelial cell development (GO:0060576)2.42681450
99transepithelial transport (GO:0070633)2.40855475
100trophoblast giant cell differentiation (GO:0060707)2.39996445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.36600476
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.95179942
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65984504
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55019350
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51758581
6TAF15_26573619_Chip-Seq_HEK293_Human2.49760254
7AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.43898542
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42726567
9FUS_26573619_Chip-Seq_HEK293_Human2.40198628
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.39725916
11GBX2_23144817_ChIP-Seq_PC3_Human2.21937633
12AR_21572438_ChIP-Seq_LNCaP_Human2.20973414
13EWS_26573619_Chip-Seq_HEK293_Human2.16259731
14P300_19829295_ChIP-Seq_ESCs_Human2.07846392
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96923606
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92803828
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90630142
18VDR_22108803_ChIP-Seq_LS180_Human1.89691205
19ZNF274_21170338_ChIP-Seq_K562_Hela1.88138546
20SMAD3_21741376_ChIP-Seq_EPCs_Human1.84790964
21SMAD4_21799915_ChIP-Seq_A2780_Human1.84337141
22FOXM1_26456572_ChIP-Seq_MCF-7_Human1.83305107
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79958865
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.75124044
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72609704
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.67614164
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64869905
28AHR_22903824_ChIP-Seq_MCF-7_Human1.61143952
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60975580
30BCAT_22108803_ChIP-Seq_LS180_Human1.60850280
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59746525
32TP53_16413492_ChIP-PET_HCT116_Human1.59676960
33STAT3_23295773_ChIP-Seq_U87_Human1.58916388
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57915902
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57915902
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.56522026
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55925999
38CBP_20019798_ChIP-Seq_JUKART_Human1.55925999
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.55202307
40ER_23166858_ChIP-Seq_MCF-7_Human1.54589571
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.53199680
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50559124
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50307990
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48435921
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47835716
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47087239
47RNF2_27304074_Chip-Seq_NSC_Mouse1.46354569
48IGF1R_20145208_ChIP-Seq_DFB_Human1.45863947
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43927746
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41801269
51CJUN_26792858_Chip-Seq_BT549_Human1.41051781
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40899966
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.40651433
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40618395
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40604862
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38057904
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.37412244
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36836173
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35536501
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34363140
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33227347
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30296751
63TCF4_22108803_ChIP-Seq_LS180_Human1.29139621
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27466004
65P53_22387025_ChIP-Seq_ESCs_Mouse1.27339299
66TCF4_23295773_ChIP-Seq_U87_Human1.26916296
67CDX2_22108803_ChIP-Seq_LS180_Human1.24617090
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.24084480
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.23050986
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22568444
71RUNX2_22187159_ChIP-Seq_PCA_Human1.20215328
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.19999212
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19677375
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19188978
75TP53_18474530_ChIP-ChIP_U2OS_Human1.18518570
76TBL1_22424771_ChIP-Seq_293T_Human1.18307887
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.18225149
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18163580
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.17667850
80AR_25329375_ChIP-Seq_VCAP_Human1.17223527
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.16620907
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.15736133
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.15570009
84RXR_22108803_ChIP-Seq_LS180_Human1.14613442
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14091162
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14091162
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12291406
88NFYB_21822215_ChIP-Seq_K562_Human1.11102311
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10494659
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.10114402
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09796748
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08334352
93NFYA_21822215_ChIP-Seq_K562_Human1.08328449
94ELK1_19687146_ChIP-ChIP_HELA_Human1.08254305
95P300_18555785_Chip-Seq_ESCs_Mouse1.06269479
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.05691975
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.04216964
98JUN_21703547_ChIP-Seq_K562_Human1.03518269
99VDR_24787735_ChIP-Seq_THP-1_Human1.02786083
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01704449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.24492994
2MP0000569_abnormal_digit_pigmentation5.35926567
3MP0003195_calcinosis3.71035644
4MP0005645_abnormal_hypothalamus_physiol3.45232135
5MP0003950_abnormal_plasma_membrane3.37117519
6MP0010386_abnormal_urinary_bladder2.28040578
7MP0006276_abnormal_autonomic_nervous2.27259505
8MP0001501_abnormal_sleep_pattern2.17878618
9MP0010352_gastrointestinal_tract_polyps2.12876442
10MP0004270_analgesia2.12298824
11MP0004043_abnormal_pH_regulation2.11100237
12MP0005670_abnormal_white_adipose1.99288390
13MP0003890_abnormal_embryonic-extraembry1.94263718
14MP0001984_abnormal_olfaction1.85197004
15MP0002009_preneoplasia1.82245272
16MP0000372_irregular_coat_pigmentation1.76282380
17MP0001529_abnormal_vocalization1.76236014
18MP0003937_abnormal_limbs/digits/tail_de1.69815068
19MP0003183_abnormal_peptide_metabolism1.67801299
20MP0000383_abnormal_hair_follicle1.65677029
21MP0005551_abnormal_eye_electrophysiolog1.62566337
22MP0001879_abnormal_lymphatic_vessel1.61284487
23MP0002751_abnormal_autonomic_nervous1.59356936
24MP0002796_impaired_skin_barrier1.56373676
25MP0005253_abnormal_eye_physiology1.51045501
26MP0002168_other_aberrant_phenotype1.39844394
27MP0008058_abnormal_DNA_repair1.39769156
28MP0001485_abnormal_pinna_reflex1.36597482
29MP0008007_abnormal_cellular_replicative1.36315452
30MP0005503_abnormal_tendon_morphology1.30229389
31MP0010678_abnormal_skin_adnexa1.30199339
32MP0002928_abnormal_bile_duct1.29379678
33MP0005084_abnormal_gallbladder_morpholo1.25292375
34MP0002909_abnormal_adrenal_gland1.22712532
35MP0003045_fibrosis1.21655383
36MP0005187_abnormal_penis_morphology1.19068731
37MP0009250_abnormal_appendicular_skeleto1.18354788
38MP0000534_abnormal_ureter_morphology1.17133858
39MP0001324_abnormal_eye_pigmentation1.15526612
40MP0005379_endocrine/exocrine_gland_phen1.13883571
41MP0000647_abnormal_sebaceous_gland1.12492395
42MP0001299_abnormal_eye_distance/1.11499242
43MP0002735_abnormal_chemical_nociception1.10855235
44MP0000778_abnormal_nervous_system1.10581256
45MP0003786_premature_aging1.09270650
46MP0002163_abnormal_gland_morphology1.07315394
47MP0009046_muscle_twitch1.05998023
48MP0000427_abnormal_hair_cycle1.05850025
49MP0000538_abnormal_urinary_bladder1.05208695
50MP0005623_abnormal_meninges_morphology1.03008417
51MP0004134_abnormal_chest_morphology1.01632406
52MP0002090_abnormal_vision1.01057256
53MP0005197_abnormal_uvea_morphology0.99306776
54MP0005310_abnormal_salivary_gland0.98453490
55MP0002638_abnormal_pupillary_reflex0.98425324
56MP0002184_abnormal_innervation0.97721494
57MP0008877_abnormal_DNA_methylation0.96391465
58MP0001346_abnormal_lacrimal_gland0.95923479
59MP0005391_vision/eye_phenotype0.95866377
60MP0001286_abnormal_eye_development0.95160187
61MP0002160_abnormal_reproductive_system0.94130053
62MP0002108_abnormal_muscle_morphology0.93965061
63MP0003943_abnormal_hepatobiliary_system0.93089186
64MP0000371_diluted_coat_color0.92768077
65MP0005195_abnormal_posterior_eye0.92252766
66MP0005395_other_phenotype0.88531923
67MP0002102_abnormal_ear_morphology0.87067190
68MP0004510_myositis0.86358320
69MP0003646_muscle_fatigue0.85298043
70MP0000631_abnormal_neuroendocrine_gland0.83764455
71MP0004484_altered_response_of0.83487549
72MP0000639_abnormal_adrenal_gland0.81789687
73MP0001191_abnormal_skin_condition0.81680925
74MP0009697_abnormal_copulation0.80232496
75MP0002233_abnormal_nose_morphology0.80008782
76MP0003942_abnormal_urinary_system0.79553995
77MP0008995_early_reproductive_senescence0.79297187
78MP0005083_abnormal_biliary_tract0.79146756
79MP0004885_abnormal_endolymph0.78435720
80MP0005174_abnormal_tail_pigmentation0.77720191
81MP0003221_abnormal_cardiomyocyte_apopto0.76637709
82MP0009780_abnormal_chondrocyte_physiolo0.75930706
83MP0004085_abnormal_heartbeat0.75578404
84MP0002332_abnormal_exercise_endurance0.74094480
85MP0005646_abnormal_pituitary_gland0.71300360
86MP0005367_renal/urinary_system_phenotyp0.69495389
87MP0000516_abnormal_urinary_system0.69495389
88MP0002752_abnormal_somatic_nervous0.68313341
89MP0002557_abnormal_social/conspecific_i0.67926324
90MP0005085_abnormal_gallbladder_physiolo0.66973087
91MP0004924_abnormal_behavior0.66651208
92MP0005386_behavior/neurological_phenoty0.66651208
93MP0009745_abnormal_behavioral_response0.64932528
94MP0003252_abnormal_bile_duct0.64902148
95MP0003787_abnormal_imprinting0.64628457
96MP0003755_abnormal_palate_morphology0.63390731
97MP0000026_abnormal_inner_ear0.62411260
98MP0009115_abnormal_fat_cell0.61854601
99MP0002166_altered_tumor_susceptibility0.61499077
100MP0001119_abnormal_female_reproductive0.58103566

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)4.19212258
2Pheochromocytoma (HP:0002666)3.93801161
3Volvulus (HP:0002580)3.91040610
4Neuroendocrine neoplasm (HP:0100634)3.88756251
5Atonic seizures (HP:0010819)3.85313984
6Tubulointerstitial nephritis (HP:0001970)3.41917876
7Long clavicles (HP:0000890)3.27785272
8Chronic hepatic failure (HP:0100626)3.18795749
9Progressive cerebellar ataxia (HP:0002073)3.08177078
10Genetic anticipation (HP:0003743)3.01867015
11Autoamputation (HP:0001218)2.91559417
12Alopecia of scalp (HP:0002293)2.89999295
13Pancreatic cysts (HP:0001737)2.77208440
14Vaginal atresia (HP:0000148)2.75850091
15True hermaphroditism (HP:0010459)2.74975225
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.73855793
17Absent/shortened dynein arms (HP:0200106)2.73855793
18Recurrent pneumonia (HP:0006532)2.73581054
19Nephronophthisis (HP:0000090)2.71240297
20Medial flaring of the eyebrow (HP:0010747)2.68565276
21Genital tract atresia (HP:0001827)2.66886300
22Vascular calcification (HP:0004934)2.66611409
23Poikiloderma (HP:0001029)2.63682371
24Chorioretinal atrophy (HP:0000533)2.60988754
25Anhidrosis (HP:0000970)2.59775995
26Macular degeneration (HP:0000608)2.56751467
27Gaze-evoked nystagmus (HP:0000640)2.55425789
28Decreased central vision (HP:0007663)2.46437597
29Diastasis recti (HP:0001540)2.46137173
3011 pairs of ribs (HP:0000878)2.44373495
31Gait imbalance (HP:0002141)2.40438696
32Blepharitis (HP:0000498)2.39269819
33Congenital primary aphakia (HP:0007707)2.37750010
34Papillary thyroid carcinoma (HP:0002895)2.36478617
35Cardiovascular calcification (HP:0011915)2.36474519
36Short chin (HP:0000331)2.34130081
37Poor coordination (HP:0002370)2.33690510
38Thyroid carcinoma (HP:0002890)2.30246211
39Cellular immunodeficiency (HP:0005374)2.27507988
40Wide intermamillary distance (HP:0006610)2.20292834
41Nephrogenic diabetes insipidus (HP:0009806)2.17574695
42Urethral obstruction (HP:0000796)2.16871177
43Abnormality of the renal medulla (HP:0100957)2.16688910
44Follicular hyperkeratosis (HP:0007502)2.16353370
45Hypophosphatemic rickets (HP:0004912)2.16137053
46Abnormal pancreas size (HP:0012094)2.13829446
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13634903
48Fair hair (HP:0002286)2.08320914
49Ectropion (HP:0000656)2.08094384
50Neoplasm of the peripheral nervous system (HP:0100007)2.05380160
51Abnormal hair whorl (HP:0010721)2.00362820
52Hypoplastic iliac wings (HP:0002866)1.99819874
53Abnormality of the labia majora (HP:0012881)1.95437668
54Menstrual irregularities (HP:0000858)1.95053168
55Hip dysplasia (HP:0001385)1.94368280
56Urinary bladder sphincter dysfunction (HP:0002839)1.92036777
57Truncal obesity (HP:0001956)1.91711046
58Aplasia/Hypoplasia of the fibula (HP:0006492)1.91347076
59Abnormality of the astrocytes (HP:0100707)1.91098105
60Astrocytoma (HP:0009592)1.91098105
61Abnormality of the axillary hair (HP:0100134)1.89263824
62Abnormality of secondary sexual hair (HP:0009888)1.89263824
63Recurrent sinusitis (HP:0011108)1.88949789
64Fibular aplasia (HP:0002990)1.86876389
65Missing ribs (HP:0000921)1.86640486
66Attenuation of retinal blood vessels (HP:0007843)1.85515237
67Fibular hypoplasia (HP:0003038)1.81495060
68Abnormality of nail color (HP:0100643)1.81431527
69Submucous cleft hard palate (HP:0000176)1.79755173
70Midline defect of the nose (HP:0004122)1.79200569
71Aplasia/Hypoplasia of the lens (HP:0008063)1.79065164
72Tubular atrophy (HP:0000092)1.78594811
73Bicornuate uterus (HP:0000813)1.78413315
74Febrile seizures (HP:0002373)1.77311659
75Sensory axonal neuropathy (HP:0003390)1.76836928
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.76309957
77Lip pit (HP:0100267)1.72395491
78Thyroid-stimulating hormone excess (HP:0002925)1.71710119
79Curly hair (HP:0002212)1.71644214
80Abnormality of the nasal septum (HP:0000419)1.70247431
81Dyschromatopsia (HP:0007641)1.68392763
82Hypoplastic labia majora (HP:0000059)1.66687837
83Abnormality of midbrain morphology (HP:0002418)1.66364493
84Molar tooth sign on MRI (HP:0002419)1.66364493
85Glioma (HP:0009733)1.63243714
86Chronic bronchitis (HP:0004469)1.62143336
87Thoracolumbar scoliosis (HP:0002944)1.61109843
88Widely spaced teeth (HP:0000687)1.60755144
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60498226
90Abnormal ciliary motility (HP:0012262)1.59663809
91Hyperventilation (HP:0002883)1.59381029
92Growth hormone deficiency (HP:0000824)1.59187155
93Inability to walk (HP:0002540)1.58868859
94Aplasia/Hypoplasia of the scapulae (HP:0006713)1.58596066
95Hypoplastic scapulae (HP:0000882)1.58596066
96Renal hypoplasia (HP:0000089)1.58571698
97Abnormal respiratory epithelium morphology (HP:0012253)1.58284181
98Abnormal respiratory motile cilium morphology (HP:0005938)1.58284181
99Thyroiditis (HP:0100646)1.57719538
100Medulloblastoma (HP:0002885)1.57132068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.12627448
2MAP3K43.32444322
3MST43.12116267
4ACVR1B2.93326836
5BCR2.36546561
6CSNK1A1L2.35021479
7MKNK22.32163398
8BRSK22.31326504
9MAP2K72.24058635
10BMPR1B2.20230166
11EIF2AK32.15100168
12MAP3K62.09126927
13TNIK2.02348045
14ADRBK21.93064421
15NEK61.89625774
16AKT31.89513976
17BLK1.87827648
18STK391.77410147
19WNK31.72801585
20ERBB31.57335106
21CASK1.57218196
22WNK11.54828621
23STK31.52626524
24GRK11.50376284
25CDK121.45177208
26CAMK1D1.40087502
27STK241.38524348
28WEE11.37038752
29BRD41.32863707
30CAMK1G1.32206582
31CSNK1G21.30775173
32MAPK131.29656289
33MAP2K41.27638450
34CSNK1G11.23697174
35CLK11.21906261
36CSNK1G31.20024840
37TIE11.17444737
38GRK71.14097972
39MARK11.11287599
40DYRK31.10204788
41TGFBR21.07638488
42MATK1.07196781
43TEC1.02822773
44WNK41.02643750
45TRIM281.00750243
46VRK11.00642232
47MKNK11.00386969
48ADRBK10.99967576
49STK38L0.98508649
50TAF10.98013656
51SRPK10.94177737
52CAMKK20.92988980
53BUB10.92517245
54PRKCE0.91625502
55EIF2AK20.88337528
56MAP3K20.87848619
57TXK0.87448886
58PNCK0.82853348
59ICK0.78973208
60BMPR20.78949977
61STK380.78525921
62TGFBR10.74093511
63SGK20.72133510
64STK100.70172773
65OXSR10.67798005
66NLK0.67061663
67NUAK10.63731308
68PRKCG0.61714048
69ATM0.61023107
70EPHA20.58424216
71CAMK40.56727084
72JAK10.51952724
73PRKAA20.51303254
74FGFR10.50416681
75ERBB40.49103595
76PLK20.47524240
77YES10.45770256
78NEK90.44385357
79PIK3CA0.42768782
80PAK30.42356071
81EGFR0.39602677
82DYRK1A0.39458916
83FLT30.38597084
84MAP2K60.38229234
85ERBB20.35588290
86INSRR0.33250217
87PDGFRB0.33013042
88ABL10.32586700
89MAP3K50.31922768
90SGK4940.31744406
91SGK2230.31744406
92LATS10.31442872
93DDR20.31126330
94PRKAA10.30663593
95PLK40.30533715
96OBSCN0.30285483
97CHEK20.28980697
98IGF1R0.28166267
99CSNK1D0.26685666
100CAMK10.26664431

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88141423
2Taste transduction_Homo sapiens_hsa047422.95480352
3Basal transcription factors_Homo sapiens_hsa030222.46645011
4Phototransduction_Homo sapiens_hsa047442.29714402
5Non-homologous end-joining_Homo sapiens_hsa034502.21193012
6Circadian rhythm_Homo sapiens_hsa047102.03432899
7Morphine addiction_Homo sapiens_hsa050322.01090089
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.94728208
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90959085
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69174239
11Protein export_Homo sapiens_hsa030601.66049834
12GABAergic synapse_Homo sapiens_hsa047271.64012795
13Dorso-ventral axis formation_Homo sapiens_hsa043201.55995746
14TGF-beta signaling pathway_Homo sapiens_hsa043501.45860615
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42623038
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36414270
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.36302572
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34600911
19Adherens junction_Homo sapiens_hsa045201.29471058
20Type II diabetes mellitus_Homo sapiens_hsa049301.27431457
21Systemic lupus erythematosus_Homo sapiens_hsa053221.26391115
22Olfactory transduction_Homo sapiens_hsa047401.24222234
23mRNA surveillance pathway_Homo sapiens_hsa030151.21115370
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20293606
25RNA degradation_Homo sapiens_hsa030181.19859736
26Sulfur metabolism_Homo sapiens_hsa009201.17446907
27p53 signaling pathway_Homo sapiens_hsa041151.14730149
28RNA transport_Homo sapiens_hsa030131.13785384
29Regulation of autophagy_Homo sapiens_hsa041401.08619040
30Serotonergic synapse_Homo sapiens_hsa047261.08034627
31Fanconi anemia pathway_Homo sapiens_hsa034601.02774210
32Alcoholism_Homo sapiens_hsa050340.99721630
33Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98125605
34Maturity onset diabetes of the young_Homo sapiens_hsa049500.98045745
35Selenocompound metabolism_Homo sapiens_hsa004500.97951989
36FoxO signaling pathway_Homo sapiens_hsa040680.97418976
37TNF signaling pathway_Homo sapiens_hsa046680.96552486
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93272453
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92882242
40Tight junction_Homo sapiens_hsa045300.92633126
41Caffeine metabolism_Homo sapiens_hsa002320.91230988
42Homologous recombination_Homo sapiens_hsa034400.89392934
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88107782
44Ether lipid metabolism_Homo sapiens_hsa005650.88096497
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85918550
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85569821
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84760838
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82705635
49Dopaminergic synapse_Homo sapiens_hsa047280.80469416
50Calcium signaling pathway_Homo sapiens_hsa040200.79466802
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.79115594
52Glycerolipid metabolism_Homo sapiens_hsa005610.78938956
53Sphingolipid metabolism_Homo sapiens_hsa006000.78556967
54Hippo signaling pathway_Homo sapiens_hsa043900.77424969
55Colorectal cancer_Homo sapiens_hsa052100.76256624
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.75482221
57Cocaine addiction_Homo sapiens_hsa050300.75178928
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74544130
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73530395
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73438564
61Wnt signaling pathway_Homo sapiens_hsa043100.71494897
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70549244
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70514043
64Choline metabolism in cancer_Homo sapiens_hsa052310.70027688
65Hedgehog signaling pathway_Homo sapiens_hsa043400.68099983
66Oocyte meiosis_Homo sapiens_hsa041140.64757417
67ABC transporters_Homo sapiens_hsa020100.63411069
68MicroRNAs in cancer_Homo sapiens_hsa052060.62819499
69Tryptophan metabolism_Homo sapiens_hsa003800.62653028
70Retinol metabolism_Homo sapiens_hsa008300.61948221
71Renal cell carcinoma_Homo sapiens_hsa052110.61404194
72Influenza A_Homo sapiens_hsa051640.60456984
73cAMP signaling pathway_Homo sapiens_hsa040240.60163403
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59675698
75Gastric acid secretion_Homo sapiens_hsa049710.58579878
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58404387
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58369171
78Nitrogen metabolism_Homo sapiens_hsa009100.57064497
79Cell cycle_Homo sapiens_hsa041100.56905410
80ErbB signaling pathway_Homo sapiens_hsa040120.55830025
81Amphetamine addiction_Homo sapiens_hsa050310.55621961
82Axon guidance_Homo sapiens_hsa043600.54442022
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51624432
84Rap1 signaling pathway_Homo sapiens_hsa040150.50911220
85Salivary secretion_Homo sapiens_hsa049700.50835864
86Renin-angiotensin system_Homo sapiens_hsa046140.50717708
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50581806
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.50487910
89Hepatitis C_Homo sapiens_hsa051600.49987085
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49907683
91Measles_Homo sapiens_hsa051620.49851415
92Rheumatoid arthritis_Homo sapiens_hsa053230.48416481
93Cholinergic synapse_Homo sapiens_hsa047250.48291646
94RNA polymerase_Homo sapiens_hsa030200.47548192
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46526823
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44813849
97Prostate cancer_Homo sapiens_hsa052150.40808476
98MAPK signaling pathway_Homo sapiens_hsa040100.40615171
99Prolactin signaling pathway_Homo sapiens_hsa049170.39802065
100Viral carcinogenesis_Homo sapiens_hsa052030.39402799

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