MAPK13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.21438525
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.74030614
3hemidesmosome assembly (GO:0031581)6.61202027
4intestinal absorption (GO:0050892)5.58559834
5regulation of water loss via skin (GO:0033561)5.58119078
6establishment of skin barrier (GO:0061436)5.32310899
7regulation of respiratory burst (GO:0060263)5.20821044
8defense response to fungus (GO:0050832)5.20454245
9intestinal epithelial cell development (GO:0060576)5.11217903
10keratinization (GO:0031424)5.10929049
11antibacterial humoral response (GO:0019731)5.04892735
12antimicrobial humoral response (GO:0019730)4.95469800
13regulation of chemokine secretion (GO:0090196)4.84536744
14molting cycle (GO:0042303)4.67060293
15hair cycle (GO:0042633)4.67060293
16ribosomal small subunit assembly (GO:0000028)4.57401478
17intestinal cholesterol absorption (GO:0030299)4.51297923
18negative regulation of keratinocyte proliferation (GO:0010839)4.48119648
19viral transcription (GO:0019083)4.44818410
20interferon-gamma secretion (GO:0072643)4.37129116
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28386979
22translational termination (GO:0006415)4.27474703
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.26351248
24calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.12681870
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06287765
26innate immune response in mucosa (GO:0002227)4.04297089
27keratinocyte proliferation (GO:0043616)4.03481470
28negative regulation of cell killing (GO:0031342)3.98224974
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98224974
30multicellular organismal water homeostasis (GO:0050891)3.87427413
31UDP-N-acetylglucosamine metabolic process (GO:0006047)3.83230178
32antigen processing and presentation of endogenous antigen (GO:0019883)3.82862900
33regulation of hydrogen peroxide metabolic process (GO:0010310)3.72983657
34hepatocyte apoptotic process (GO:0097284)3.70135792
35macrophage activation involved in immune response (GO:0002281)3.70041320
36ribosomal large subunit biogenesis (GO:0042273)3.69175126
37virion attachment to host cell (GO:0019062)3.67379242
38adhesion of symbiont to host cell (GO:0044650)3.67379242
39translational elongation (GO:0006414)3.65328420
40keratinocyte differentiation (GO:0030216)3.62692938
41neutrophil activation involved in immune response (GO:0002283)3.62431767
42tight junction assembly (GO:0070830)3.61462759
43actin filament depolymerization (GO:0030042)3.60822894
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60188800
45primary alcohol catabolic process (GO:0034310)3.60030908
46viral life cycle (GO:0019058)3.59613624
47negative regulation of interleukin-12 production (GO:0032695)3.58699391
48disruption of cells of other organism (GO:0044364)3.58623790
49killing of cells of other organism (GO:0031640)3.58623790
50mucosal immune response (GO:0002385)3.54761410
51protein targeting to ER (GO:0045047)3.52367045
52positive regulation of epidermal cell differentiation (GO:0045606)3.49356792
53cotranslational protein targeting to membrane (GO:0006613)3.47537944
54cellular protein complex disassembly (GO:0043624)3.47184750
55intermediate filament organization (GO:0045109)3.44661243
56diol metabolic process (GO:0034311)3.43473775
57positive regulation by symbiont of host defense response (GO:0052509)3.43181161
58modulation by symbiont of host defense response (GO:0052031)3.43181161
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43181161
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43181161
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.43181161
62modulation by symbiont of host immune response (GO:0052553)3.43181161
63positive regulation of chemokine secretion (GO:0090197)3.41900221
64negative regulation of epidermal cell differentiation (GO:0045605)3.41842635
65detection of bacterium (GO:0016045)3.40722959
66negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.40202396
67sphingoid metabolic process (GO:0046519)3.39897801
68ribosomal small subunit biogenesis (GO:0042274)3.38331360
69response to peptidoglycan (GO:0032494)3.38110011
70phospholipid scrambling (GO:0017121)3.37990137
71maturation of SSU-rRNA (GO:0030490)3.37260076
72positive regulation of gamma-delta T cell activation (GO:0046645)3.36827337
73regulation of keratinocyte proliferation (GO:0010837)3.36601599
74positive regulation of Cdc42 GTPase activity (GO:0043089)3.36100577
75response to fungus (GO:0009620)3.34638851
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32054139
77organ or tissue specific immune response (GO:0002251)3.31623400
78cell differentiation involved in embryonic placenta development (GO:0060706)3.31536328
79protein localization to endoplasmic reticulum (GO:0070972)3.29916033
80regulation of podosome assembly (GO:0071801)3.27460943
81regulation of interleukin-8 secretion (GO:2000482)3.24774143
82ventricular cardiac muscle cell action potential (GO:0086005)3.23494963
83angiotensin maturation (GO:0002003)3.23369406
84maintenance of gastrointestinal epithelium (GO:0030277)3.20789398
85oligosaccharide catabolic process (GO:0009313)3.16558921
86proline biosynthetic process (GO:0006561)3.14227686
87NIK/NF-kappaB signaling (GO:0038061)3.12197803
88regulation of interferon-beta biosynthetic process (GO:0045357)3.11308084
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10843739
90digestive system process (GO:0022600)3.10186851
91regulation of cellular extravasation (GO:0002691)3.09457440
92leukotriene biosynthetic process (GO:0019370)3.09434958
93translational initiation (GO:0006413)3.06928350
94water homeostasis (GO:0030104)3.06662077
95epidermal cell differentiation (GO:0009913)3.05690968
96trophectodermal cell differentiation (GO:0001829)3.05197929
97positive regulation of interleukin-8 secretion (GO:2000484)3.04922524
98adhesion of symbiont to host (GO:0044406)3.04755201
99granulocyte activation (GO:0036230)3.03553885
100peptide catabolic process (GO:0043171)3.03278119
101detection of external biotic stimulus (GO:0098581)3.01952045
102keratinocyte development (GO:0003334)3.01902996
103phosphatidylinositol acyl-chain remodeling (GO:0036149)3.01542292
104immunoglobulin mediated immune response (GO:0016064)2.99960435
105glycosphingolipid catabolic process (GO:0046479)2.99040784
106negative regulation of epidermis development (GO:0045683)2.97648343
107atrioventricular valve morphogenesis (GO:0003181)2.97220694
108peptide cross-linking (GO:0018149)2.97042539
109response to type I interferon (GO:0034340)2.96264645
110sphingosine metabolic process (GO:0006670)2.95652283
111germinal center formation (GO:0002467)2.95214994
112protein complex disassembly (GO:0043241)2.94251272
113neutrophil activation (GO:0042119)2.94010212
114type I interferon signaling pathway (GO:0060337)2.93886467
115cellular response to type I interferon (GO:0071357)2.93886467
116detection of other organism (GO:0098543)2.92707882
117ethanol metabolic process (GO:0006067)2.90956060
118regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.90027880
119lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87642238
120regulation of gamma-delta T cell activation (GO:0046643)2.86413559
121detection of molecule of bacterial origin (GO:0032490)2.83883901
122regulation of keratinocyte differentiation (GO:0045616)2.83532266
123positive regulation of epidermis development (GO:0045684)2.81846392
124membrane budding (GO:0006900)2.81756499
125leukotriene metabolic process (GO:0006691)2.81399800
126cellular extravasation (GO:0045123)2.78989123
127interferon-gamma-mediated signaling pathway (GO:0060333)2.78924413
128phosphatidylserine acyl-chain remodeling (GO:0036150)2.78123093
129detection of biotic stimulus (GO:0009595)2.77007112
130glycolipid catabolic process (GO:0019377)2.76229315
131vitamin A metabolic process (GO:0006776)2.76183343
132regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73815112
133regulation of vitamin metabolic process (GO:0030656)2.73734693
134epithelial cell-cell adhesion (GO:0090136)2.71672911
135myeloid dendritic cell differentiation (GO:0043011)2.70959576
136T-helper 1 type immune response (GO:0042088)2.70457027
137citrulline biosynthetic process (GO:0019240)2.69862617
138macromolecular complex disassembly (GO:0032984)2.69742270
139GDP-mannose metabolic process (GO:0019673)2.67889242
140regulation of T cell tolerance induction (GO:0002664)2.66612699
141regulation of vitamin D biosynthetic process (GO:0060556)2.65037176
142defense response to protozoan (GO:0042832)2.61128755
143ceramide catabolic process (GO:0046514)2.60584611
144macrophage activation (GO:0042116)2.60542621
145dendritic cell chemotaxis (GO:0002407)2.59998578
146response to protozoan (GO:0001562)2.59547201
147respiratory burst (GO:0045730)2.59232868
148regulation of regulatory T cell differentiation (GO:0045589)2.57197889
149leukocyte aggregation (GO:0070486)2.56496709
150regulation of mast cell degranulation (GO:0043304)2.55983690
151regulation of cholesterol homeostasis (GO:2000188)2.55711472
152positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55438660
153positive regulation of antigen processing and presentation (GO:0002579)2.53522451
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53487221
155mannose metabolic process (GO:0006013)2.53401237
156regulation of leukocyte degranulation (GO:0043300)2.50011885
157myeloid cell activation involved in immune response (GO:0002275)2.49343627
158regulation of T-helper 2 cell differentiation (GO:0045628)2.48923924
159negative regulation of lymphocyte mediated immunity (GO:0002707)2.48919418
160regulation of gamma-delta T cell differentiation (GO:0045586)2.48217230
161negative regulation of cytokine production involved in immune response (GO:0002719)2.47665161
162regulation of T cell mediated cytotoxicity (GO:0001914)2.45211963
163production of molecular mediator involved in inflammatory response (GO:0002532)2.43313098
164regulation of cytokine secretion involved in immune response (GO:0002739)2.43144867
165regulation of antigen processing and presentation (GO:0002577)2.43041098
166membrane lipid catabolic process (GO:0046466)2.42560818
167regulation of dendritic cell antigen processing and presentation (GO:0002604)2.42206946
168positive regulation of leukocyte degranulation (GO:0043302)2.41989708
169amyloid precursor protein catabolic process (GO:0042987)2.41577395
170sphingolipid catabolic process (GO:0030149)2.41488116
171positive regulation of chemokine biosynthetic process (GO:0045080)2.37846704
172positive regulation of toll-like receptor signaling pathway (GO:0034123)2.37629581
173regulation of myeloid leukocyte mediated immunity (GO:0002886)2.37577773
174negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37535039
175positive regulation of T cell mediated cytotoxicity (GO:0001916)2.37274486
176amino sugar catabolic process (GO:0046348)2.36977010
177regulation of mast cell activation involved in immune response (GO:0033006)2.36287266
178regulation of interferon-alpha production (GO:0032647)2.34981367
179negative regulation of interleukin-6 production (GO:0032715)2.34730673
180negative regulation of leukocyte mediated immunity (GO:0002704)2.34701643
181regulation of tolerance induction (GO:0002643)2.34105498
182dendritic cell migration (GO:0036336)2.33838036
183regulation of B cell receptor signaling pathway (GO:0050855)2.31690465
184positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.31457065
185regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.31231485
186myeloid dendritic cell activation (GO:0001773)2.30867292
187positive regulation of NF-kappaB import into nucleus (GO:0042346)2.29839450
188regulation of leukocyte mediated cytotoxicity (GO:0001910)2.29136599
189regulation of natural killer cell mediated immunity (GO:0002715)2.28892674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.73186868
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.58902404
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.48860949
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.13061967
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.05539590
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88594957
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.85318565
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67284270
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.63924429
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63524422
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.61819600
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39673487
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39391487
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39295998
15GATA4_25053715_ChIP-Seq_YYC3_Human2.37439124
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32353081
17SOX2_20726797_ChIP-Seq_SW620_Human2.23025927
18* GATA6_25053715_ChIP-Seq_YYC3_Human2.22028756
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.20411878
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.16152457
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07224885
22* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.03458559
23TP63_17297297_ChIP-ChIP_HaCaT_Human12.7942065
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99488264
25E2F7_22180533_ChIP-Seq_HELA_Human1.98902101
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97437309
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94776032
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88862862
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88862862
30AR_21909140_ChIP-Seq_LNCAP_Human1.88009650
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.81434913
32VDR_24763502_ChIP-Seq_THP-1_Human1.81206001
33* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80068807
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78256517
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77135177
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76202663
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74536569
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73721858
39ATF3_27146783_Chip-Seq_COLON_Human1.72539839
40SPI1_23127762_ChIP-Seq_K562_Human1.70510877
41RACK7_27058665_Chip-Seq_MCF-7_Human1.70120260
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68176508
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67978664
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.66394358
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65341200
46RUNX_20019798_ChIP-Seq_JUKART_Human1.64655958
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61418455
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60109489
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59371033
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.59335687
51* VDR_24787735_ChIP-Seq_THP-1_Human1.58549704
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55362518
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.54512340
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53611283
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53001883
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.52874459
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.51161878
58SPI1_23547873_ChIP-Seq_NB4_Human1.50442036
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49367859
60ZNF263_19887448_ChIP-Seq_K562_Human1.49334936
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48428166
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.47805391
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46048564
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44131608
65MAF_26560356_Chip-Seq_TH1_Human1.44034042
66* RUNX1_27514584_Chip-Seq_MCF-7_Human1.42226579
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40019325
68TCF7_22412390_ChIP-Seq_EML_Mouse1.39821796
69* KLF5_25053715_ChIP-Seq_YYC3_Human1.39151025
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38663606
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37668973
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36958647
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35493014
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33407951
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33264617
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32134119
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29527671
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29453189
79MYB_26560356_Chip-Seq_TH2_Human1.29393644
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28859324
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26117912
82* GATA2_21666600_ChIP-Seq_HMVEC_Human1.25881750
83* LXR_22158963_ChIP-Seq_LIVER_Mouse1.25542752
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23901292
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21874100
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21829579
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21649681
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20505304
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20018690
90MYB_26560356_Chip-Seq_TH1_Human1.20003506
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.18321683
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17879305
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17751095
94UTX_26944678_Chip-Seq_JUKART_Human1.17523618
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15159152
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14124042
97SCL_19346495_ChIP-Seq_HPC-7_Human1.13263678
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12604939
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12474035
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12423437
101* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12158007
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10550516
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09959472
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09840161
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08145446
106KDM2B_26808549_Chip-Seq_DND41_Human1.08073619
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07985676
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07461250
109GATA3_24758297_ChIP-Seq_MCF-7_Human1.07004049
110* GATA1_19941826_ChIP-Seq_K562_Human1.05451711
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04258703
112MAF_26560356_Chip-Seq_TH2_Human1.04165397
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04055719
114MYC_22102868_ChIP-Seq_BL_Human1.03189229
115GATA3_27048872_Chip-Seq_THYMUS_Human1.02768460
116ELK1_22589737_ChIP-Seq_MCF10A_Human1.02605325
117PU_27001747_Chip-Seq_BMDM_Mouse1.01745858
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01309404
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00379474
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99740699
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.98799044
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98749871
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98383397
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98295300
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96943095
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95022907
127TP63_22573176_ChIP-Seq_HFKS_Human0.93620127
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.93513226
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93173336
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92189216
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91630010
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91439766
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89309779
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89279962
135LXR_22292898_ChIP-Seq_THP-1_Human0.88737410
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86367576
137* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86010305
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85709677
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84521436
140* BCOR_27268052_Chip-Seq_Bcells_Human0.84405826
141* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84200093
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83933675
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83933675
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83933675
145* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83311050
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83168675
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82121689
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81534341
149MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80868106
150* BCL6_27268052_Chip-Seq_Bcells_Human0.78847040
151* PHF8_20622854_ChIP-Seq_HELA_Human0.77143847
152XRN2_22483619_ChIP-Seq_HELA_Human0.76051451
153MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75557622
154CHD1_26751641_Chip-Seq_LNCaP_Human0.74126944
155* ELK3_25401928_ChIP-Seq_HUVEC_Human0.73231925
156CTCF_20526341_ChIP-Seq_ESCs_Human0.72266622
157SA1_27219007_Chip-Seq_ERYTHROID_Human0.72184710
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71515869
159VDR_21846776_ChIP-Seq_THP-1_Human0.71026115
160* P68_20966046_ChIP-Seq_HELA_Human0.69619187
161EGR1_19032775_ChIP-ChIP_M12_Human0.67600308
162* NANOG_20526341_ChIP-Seq_ESCs_Human0.67092089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.36683975
2MP0002796_impaired_skin_barrier4.11673172
3MP0003303_peritoneal_inflammation3.21122435
4MP0003724_increased_susceptibility_to3.12595330
5MP0008004_abnormal_stomach_pH3.04165347
6MP0004264_abnormal_extraembryonic_tissu2.98258318
7MP0001666_abnormal_nutrient_absorption2.91594319
8MP0003941_abnormal_skin_development2.81125289
9MP0005501_abnormal_skin_physiology2.77587210
10MP0005058_abnormal_lysosome_morphology2.75129427
11MP0000462_abnormal_digestive_system2.66108541
12MP0006082_CNS_inflammation2.62035783
13MP0002254_reproductive_system_inflammat2.57817732
14MP0000579_abnormal_nail_morphology2.53279977
15MP0009379_abnormal_foot_pigmentation2.52849507
16MP0001835_abnormal_antigen_presentation2.49729598
17MP0001790_abnormal_immune_system2.42509481
18MP0005387_immune_system_phenotype2.42509481
19MP0002098_abnormal_vibrissa_morphology2.40613105
20MP0001873_stomach_inflammation2.39546723
21MP0005275_abnormal_skin_tensile2.38621060
22MP0005671_abnormal_response_to2.35386453
23MP0003705_abnormal_hypodermis_morpholog2.33092410
24MP0003453_abnormal_keratinocyte_physiol2.31554078
25MP0000490_abnormal_crypts_of2.26815564
26MP0010678_abnormal_skin_adnexa2.26697296
27MP0001216_abnormal_epidermal_layer2.25471447
28MP0002419_abnormal_innate_immunity2.25033623
29MP0002060_abnormal_skin_morphology2.24642396
30MP0010352_gastrointestinal_tract_polyps2.23451425
31MP0002139_abnormal_hepatobiliary_system2.21058886
32MP0005360_urolithiasis2.17791857
33MP0000537_abnormal_urethra_morphology2.15464022
34MP0005000_abnormal_immune_tolerance2.13833968
35MP0003866_abnormal_defecation2.09105067
36MP0010155_abnormal_intestine_physiology2.06259234
37MP0003172_abnormal_lysosome_physiology2.00576927
38MP0000685_abnormal_immune_system1.99955067
39MP0003300_gastrointestinal_ulcer1.99863087
40MP0000383_abnormal_hair_follicle1.98307166
41MP0001800_abnormal_humoral_immune1.95518930
42MP0002277_abnormal_respiratory_mucosa1.90049701
43MP0002723_abnormal_immune_serum1.87262014
44MP0001533_abnormal_skeleton_physiology1.87204065
45MP0002452_abnormal_antigen_presenting1.86547231
46MP0004947_skin_inflammation1.85608144
47MP0010771_integument_phenotype1.76362796
48MP0005310_abnormal_salivary_gland1.75687925
49MP0000467_abnormal_esophagus_morphology1.74205193
50MP0003693_abnormal_embryo_hatching1.71090900
51MP0001663_abnormal_digestive_system1.69802843
52MP0002420_abnormal_adaptive_immunity1.68167053
53MP0001819_abnormal_immune_cell1.68134331
54MP0009333_abnormal_splenocyte_physiolog1.67057284
55MP0005381_digestive/alimentary_phenotyp1.65082048
56MP0000377_abnormal_hair_follicle1.63083727
57MP0004510_myositis1.59943017
58MP0003566_abnormal_cell_adhesion1.55725674
59MP0003075_altered_response_to1.54615874
60MP0000477_abnormal_intestine_morphology1.54408680
61MP0005365_abnormal_bile_salt1.53154555
62MP0009840_abnormal_foam_cell1.51654486
63MP0001849_ear_inflammation1.51386935
64MP0006054_spinal_hemorrhage1.51095141
65MP0009764_decreased_sensitivity_to1.44309458
66MP0001664_abnormal_digestion1.41243103
67MP0008469_abnormal_protein_level1.41241606
68MP0000566_synostosis1.40362221
69MP0004782_abnormal_surfactant_physiolog1.39075342
70MP0000604_amyloidosis1.38364559
71MP0002998_abnormal_bone_remodeling1.34233067
72MP0003763_abnormal_thymus_physiology1.33836035
73MP0000762_abnormal_tongue_morphology1.32241015
74MP0003123_paternal_imprinting1.31453042
75MP0004019_abnormal_vitamin_homeostasis1.31106848
76MP0000647_abnormal_sebaceous_gland1.29676246
77MP0004957_abnormal_blastocyst_morpholog1.20027580
78MP0009384_cardiac_valve_regurgitation1.19824156
79MP0005023_abnormal_wound_healing1.19214654
80MP0003315_abnormal_perineum_morphology1.18341890
81MP0000538_abnormal_urinary_bladder1.18069348
82MP0005464_abnormal_platelet_physiology1.17340401
83MP0000716_abnormal_immune_system1.16981899
84MP0000678_abnormal_parathyroid_gland1.15142112
85MP0008260_abnormal_autophagy1.14164059
86MP0000470_abnormal_stomach_morphology1.13635001
87MP0001853_heart_inflammation1.12088521
88MP0000465_gastrointestinal_hemorrhage1.09777137
89MP0009053_abnormal_anal_canal1.08631076
90MP0009931_abnormal_skin_appearance1.05510913
91MP0000427_abnormal_hair_cycle1.05262397
92MP0009785_altered_susceptibility_to1.05256075
93MP0003195_calcinosis1.04878371
94MP0005377_hearing/vestibular/ear_phenot1.04406621
95MP0003878_abnormal_ear_physiology1.04406621
96MP0000613_abnormal_salivary_gland1.03573372
97MP0001191_abnormal_skin_condition1.02194908
98MP0001346_abnormal_lacrimal_gland1.00805395
99MP0003183_abnormal_peptide_metabolism0.99769156
100MP0005164_abnormal_response_to0.98890103
101MP0005085_abnormal_gallbladder_physiolo0.98054461
102MP0003448_altered_tumor_morphology0.97928766
103MP0000343_altered_response_to0.97902515
104MP0010030_abnormal_orbit_morphology0.95987880
105MP0001765_abnormal_ion_homeostasis0.95392382
106MP0003045_fibrosis0.94352794
107MP0000858_altered_metastatic_potential0.94302195
108MP0004381_abnormal_hair_follicle0.93128763
109MP0004883_abnormal_blood_vessel0.93114547
110MP0001851_eye_inflammation0.92056575
111MP0002398_abnormal_bone_marrow0.91461016
112MP0005167_abnormal_blood-brain_barrier0.89328413
113MP0000627_abnormal_mammary_gland0.86697716
114MP0002138_abnormal_hepatobiliary_system0.85789327
115MP0002132_abnormal_respiratory_system0.85203148
116MP0002429_abnormal_blood_cell0.84870765
117MP0003191_abnormal_cellular_cholesterol0.83940496
118MP0002933_joint_inflammation0.83920419
119MP0003436_decreased_susceptibility_to0.83580773
120MP0003329_amyloid_beta_deposits0.82296767
121MP0005451_abnormal_body_composition0.81151348
122MP0003806_abnormal_nucleotide_metabolis0.80450693
123MP0002009_preneoplasia0.79598601
124MP0000689_abnormal_spleen_morphology0.79382213
125MP0000367_abnormal_coat/_hair0.78603058
126MP0010329_abnormal_lipoprotein_level0.77241637
127MP0001243_abnormal_dermal_layer0.76812270
128MP0002148_abnormal_hypersensitivity_rea0.76713576
129MP0000609_abnormal_liver_physiology0.76289115
130MP0004043_abnormal_pH_regulation0.76219885
131MP0002722_abnormal_immune_system0.75274826
132MP0009643_abnormal_urine_homeostasis0.75163313
133MP0005076_abnormal_cell_differentiation0.74409576
134MP0002136_abnormal_kidney_physiology0.74304724
135MP0002166_altered_tumor_susceptibility0.74081153
136MP0002118_abnormal_lipid_homeostasis0.71308992
137MP0003119_abnormal_digestive_system0.70371279
138MP0000516_abnormal_urinary_system0.69036176
139MP0005367_renal/urinary_system_phenotyp0.69036176
140MP0000249_abnormal_blood_vessel0.68226896
141MP0001881_abnormal_mammary_gland0.68075610
142MP0009278_abnormal_bone_marrow0.67051437
143MP0003718_maternal_effect0.64903138
144MP0002006_tumorigenesis0.62942207
145MP0005025_abnormal_response_to0.61576190
146MP0002089_abnormal_postnatal_growth/wei0.60540754
147MP0005083_abnormal_biliary_tract0.59122110
148MP0005220_abnormal_exocrine_pancreas0.57853686
149MP0001845_abnormal_inflammatory_respons0.56886688
150MP0005174_abnormal_tail_pigmentation0.54078217
151MP0005084_abnormal_gallbladder_morpholo0.50867616
152MP0003283_abnormal_digestive_organ0.50745127
153MP0002405_respiratory_system_inflammati0.48243114
154MP0004185_abnormal_adipocyte_glucose0.48058280
155MP0005166_decreased_susceptibility_to0.47807800
156MP0004272_abnormal_basement_membrane0.47484272

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.35276266
2Pili torti (HP:0003777)5.89932540
3Ileus (HP:0002595)5.56975683
4Onycholysis (HP:0001806)5.42584555
5Milia (HP:0001056)5.17725309
6Woolly hair (HP:0002224)5.06786678
7Fragile nails (HP:0001808)4.96805045
8Abnormality of glycolipid metabolism (HP:0010969)4.81515874
9Abnormality of liposaccharide metabolism (HP:0010968)4.81515874
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.81515874
11Plantar hyperkeratosis (HP:0007556)4.70353138
12Abnormality of macrophages (HP:0004311)4.63350019
13Ventricular fibrillation (HP:0001663)4.35798436
14Recurrent bacterial skin infections (HP:0005406)4.21516273
15Orchitis (HP:0100796)4.10579364
16Vacuolated lymphocytes (HP:0001922)4.10442180
17Atrophic scars (HP:0001075)3.97887458
18Myositis (HP:0100614)3.96714820
19Rectal prolapse (HP:0002035)3.94546975
20Increased cerebral lipofuscin (HP:0011813)3.88325081
21Recurrent abscess formation (HP:0002722)3.87665983
22Optic neuritis (HP:0100653)3.76378873
23Retrobulbar optic neuritis (HP:0100654)3.76378873
24Abnormal hair laboratory examination (HP:0003328)3.75722692
25Systemic lupus erythematosus (HP:0002725)3.70711134
26Pustule (HP:0200039)3.67521459
27Palmoplantar hyperkeratosis (HP:0000972)3.51868043
28Dysostosis multiplex (HP:0000943)3.50050690
29Stomatitis (HP:0010280)3.49492539
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.48192713
31Hypotrichosis (HP:0001006)3.37754853
32Increased IgE level (HP:0003212)3.37563029
33Congenital sensorineural hearing impairment (HP:0008527)3.29847504
34Loss of speech (HP:0002371)3.28737901
35Nail dystrophy (HP:0008404)3.28388161
36Palmar hyperkeratosis (HP:0010765)3.26612362
37Mediastinal lymphadenopathy (HP:0100721)3.12399456
38Abnormality of polysaccharide metabolism (HP:0011012)3.11287301
39Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11287301
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11287301
41Fragile skin (HP:0001030)3.10737096
42Abnormal blistering of the skin (HP:0008066)3.10280446
43Abnormal hemoglobin (HP:0011902)3.09837179
44Trismus (HP:0000211)3.09476008
45Reticulocytopenia (HP:0001896)3.00015817
46Abnormality of cells of the erythroid lineage (HP:0012130)2.98342616
47Urinary glycosaminoglycan excretion (HP:0003541)2.97150024
48Mucopolysacchariduria (HP:0008155)2.97150024
49Recurrent gram-negative bacterial infections (HP:0005420)2.94204755
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.92541723
51Sparse eyelashes (HP:0000653)2.91939736
52Elevated erythrocyte sedimentation rate (HP:0003565)2.91507711
53Congenital ichthyosiform erythroderma (HP:0007431)2.90432583
54Abnormality of the gastric mucosa (HP:0004295)2.85428209
55Keratoconjunctivitis sicca (HP:0001097)2.80853615
56Abnormality of nail color (HP:0100643)2.77410586
57Abnormal number of erythroid precursors (HP:0012131)2.75458609
58Malnutrition (HP:0004395)2.73486275
59Curly hair (HP:0002212)2.71147923
60Glomerulonephritis (HP:0000099)2.69247827
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67746766
62Pulmonary infiltrates (HP:0002113)2.67729367
63Conjunctival hamartoma (HP:0100780)2.67454053
64Recurrent skin infections (HP:0001581)2.66115946
65Keratoconjunctivitis (HP:0001096)2.65024251
66Gingivitis (HP:0000230)2.63641718
67Ridged nail (HP:0001807)2.63173646
68Lip pit (HP:0100267)2.62286895
69Alopecia of scalp (HP:0002293)2.62204735
70Hydroxyprolinuria (HP:0003080)2.58359537
71Abnormality of proline metabolism (HP:0010907)2.58359537
72Biliary tract neoplasm (HP:0100574)2.53982118
73Vasculitis (HP:0002633)2.52584608
74Cheilitis (HP:0100825)2.50914955
75Disinhibition (HP:0000734)2.49011734
76Dehydration (HP:0001944)2.47356831
77Interstitial pulmonary disease (HP:0006530)2.47188825
78Recurrent fungal infections (HP:0002841)2.46961432
79Chronic diarrhea (HP:0002028)2.46430987
80Axonal loss (HP:0003447)2.45126057
81Gangrene (HP:0100758)2.44267158
82Abnormal biliary tract morphology (HP:0012440)2.42700938
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40932753
84Premature loss of primary teeth (HP:0006323)2.38014374
85Obstructive lung disease (HP:0006536)2.36100351
86Chronic obstructive pulmonary disease (HP:0006510)2.36100351
87Oral leukoplakia (HP:0002745)2.34534926
88Micronodular cirrhosis (HP:0001413)2.33373694
89Amyloidosis (HP:0011034)2.33127983
90Gastrointestinal infarctions (HP:0005244)2.30222883
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30020025
92Hemoptysis (HP:0002105)2.27900960
93Abnormality of chloride homeostasis (HP:0011422)2.27461073
94Abdominal distention (HP:0003270)2.26416761
95Increased serum ferritin (HP:0003281)2.24207253
96Ventricular tachycardia (HP:0004756)2.23553666
97Gastrointestinal dysmotility (HP:0002579)2.22532250
98Meningitis (HP:0001287)2.21855413
99Blepharitis (HP:0000498)2.18519443
100Ankyloglossia (HP:0010296)2.18486103
101Hypoplasia of dental enamel (HP:0006297)2.17359223
102Eczematoid dermatitis (HP:0000976)2.16913318
103Colon cancer (HP:0003003)2.16611122
104Neurofibrillary tangles (HP:0002185)2.16562762
105Pterygium (HP:0001059)2.15145416
106Congenital, generalized hypertrichosis (HP:0004540)2.11197395
107Encephalitis (HP:0002383)2.09567423
108Metaphyseal irregularity (HP:0003025)2.07404791
109Purpura (HP:0000979)2.07127515
110Abnormality of the distal phalanges of the toes (HP:0010182)2.07007589
111Esophageal atresia (HP:0002032)2.06258824
112Macrocytic anemia (HP:0001972)2.05636418
113Widely patent fontanelles and sutures (HP:0004492)2.04970639
114Decreased circulating renin level (HP:0003351)2.02952063
115Thin bony cortex (HP:0002753)2.02696565
116Episodic fever (HP:0001954)2.02580702
117Abnormality of iron homeostasis (HP:0011031)2.02098058
118Periodontitis (HP:0000704)2.01655141
119T lymphocytopenia (HP:0005403)2.01184611
120Villous atrophy (HP:0011473)2.00934841
121Abnormality of small intestinal villus morphology (HP:0011472)2.00934841
122Hemorrhage of the eye (HP:0011885)1.99295125
123Segmental peripheral demyelination/remyelination (HP:0003481)1.98119592
124Abnormality of T cell number (HP:0011839)1.98104295
125Hyperparathyroidism (HP:0000843)1.97850573
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.96963148
127Spontaneous hematomas (HP:0007420)1.96715803
128Hypoplasia of the uterus (HP:0000013)1.96391662
129Parakeratosis (HP:0001036)1.95977447
130Xanthomatosis (HP:0000991)1.95272967
131Hyperactive renin-angiotensin system (HP:0000841)1.95220923
132Petechiae (HP:0000967)1.94542604
133Aplasia cutis congenita (HP:0001057)1.94494016
134Corneal erosion (HP:0200020)1.91490097
135Acne (HP:0001061)1.91489131
136Erythema (HP:0010783)1.91323833
137Increased CSF protein (HP:0002922)1.90453446
138Inflammation of the large intestine (HP:0002037)1.89535774
139Progressive neurologic deterioration (HP:0002344)1.88644937
140Hypergammaglobulinemia (HP:0010702)1.87303320
141Rough bone trabeculation (HP:0100670)1.86203360
142Myocardial infarction (HP:0001658)1.83677922
143Anorexia (HP:0002039)1.82902557
144Exocrine pancreatic insufficiency (HP:0001738)1.82618863
145Hematochezia (HP:0002573)1.82246157
146Microretrognathia (HP:0000308)1.82193758
147Thick nail (HP:0001805)1.82093801
148Nephritis (HP:0000123)1.81687025
149Gastrointestinal inflammation (HP:0004386)1.81583551
150Male infertility (HP:0003251)1.81378970
15111 pairs of ribs (HP:0000878)1.80455854
152Amniotic constriction ring (HP:0009775)1.79256113
153Abnormality of placental membranes (HP:0011409)1.79256113
154Joint swelling (HP:0001386)1.79215391
155Syncope (HP:0001279)1.78105269
156Arterial thrombosis (HP:0004420)1.77684705
157Abnormality of the pleura (HP:0002103)1.77671533
158Pulmonary embolism (HP:0002204)1.77608273
159Pallor (HP:0000980)1.77240742
160Abnormality of transition element cation homeostasis (HP:0011030)1.76991842
161Amelogenesis imperfecta (HP:0000705)1.76851103
162Palpitations (HP:0001962)1.76653234
163Stenosis of the external auditory canal (HP:0000402)1.76401685
164Posterior subcapsular cataract (HP:0007787)1.74127480
165Uterine neoplasm (HP:0010784)1.73073390
166Hypoalbuminemia (HP:0003073)1.73036862
167Abnormal albumin level (HP:0012116)1.73036862
168Ureteral stenosis (HP:0000071)1.73003462
169Palmoplantar keratoderma (HP:0000982)1.72807486
170Poikiloderma (HP:0001029)1.71767123
171Myopathic facies (HP:0002058)1.71537127
172Ectropion (HP:0000656)1.71070695
173Skin ulcer (HP:0200042)1.70842909
174Ventricular arrhythmia (HP:0004308)1.69723815
175Autoimmune thrombocytopenia (HP:0001973)1.67910787
176Anonychia (HP:0001798)1.64775158
177Nausea (HP:0002018)1.63387936
178Urticaria (HP:0001025)1.62894980
179Aplasia/hypoplasia of the uterus (HP:0008684)1.62103051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.56390629
2LMTK24.28295924
3MST43.81439796
4FRK3.80715719
5MST1R3.70807615
6NME12.79065990
7RIPK42.78481874
8MAP4K12.74486884
9MAP3K32.71140808
10TESK12.47116077
11MAP2K22.42098972
12PRKG22.29792542
13ACVR1B2.24360646
14TYK22.22581444
15EIF2AK12.11170662
16MAPKAPK32.02983892
17ERN12.00082292
18RPS6KB21.99181263
19MAP3K141.98334406
20TXK1.85921199
21PTK61.84355370
22MAP3K111.84051028
23PRPF4B1.79051564
24EPHB21.70790591
25NUAK11.62742988
26MAP2K31.57763119
27RPS6KA41.53256304
28PAK41.49147345
29FGR1.48603744
30IKBKE1.47366984
31STK101.47281901
32FER1.41703881
33TRPM71.38605151
34PTK21.36485008
35IKBKB1.36273035
36CDC42BPA1.35438503
37SIK11.32653071
38MET1.32486350
39PIM21.32130368
40PBK1.31935226
41MAP3K131.29873024
42LRRK21.29401916
43RIPK11.27467280
44EEF2K1.26948093
45MAP3K21.25137229
46PKN21.24792064
47TAOK11.23898533
48TNK21.23877772
49IRAK11.23324965
50GRK71.20404496
51IRAK41.09992515
52JAK31.09341804
53EPHB11.08464287
54MAP3K81.07870949
55NME21.07550051
56FGFR31.07497042
57BLK1.07252610
58JAK11.06657259
59BUB11.06569458
60SIK31.05739101
61LATS11.01192322
62ERBB31.00780666
63EPHA30.99586842
64CSF1R0.98587804
65AURKB0.98224171
66TRIB30.96299605
67MAP2K10.94450450
68TTK0.94319366
69PRKCI0.93305417
70JAK20.92865648
71MYLK0.89688063
72HCK0.89467272
73CAMKK20.87615631
74GRK60.87265859
75LIMK10.85073291
76BMPR20.83617933
77MAP3K120.82171402
78LCK0.82154497
79PDPK10.80604416
80LYN0.79849101
81PDK10.79659991
82TAOK30.79490209
83ERBB20.78325612
84TLK10.78305285
85PIK3CG0.77153658
86IRAK20.76674536
87SMG10.75999287
88SYK0.75805582
89FES0.75448562
90PRKD20.75374050
91ITK0.75086066
92MAP3K10.75068865
93STK240.72585059
94IRAK30.72014129
95NEK20.71664683
96MAPKAPK20.69032700
97HIPK20.68086174
98TESK20.67915378
99MARK20.66411278
100DAPK20.65881021
101DYRK1B0.60161865
102MAP3K50.59260507
103PRKAA20.58665771
104YES10.58181678
105STK390.55154046
106ICK0.54069507
107VRK10.53679607
108* MAP2K60.53311705
109PIK3CA0.53130905
110STK38L0.52630025
111SIK20.50554364
112ADRBK20.50281116
113PAK10.48846047
114NLK0.47758328
115CSK0.47525028
116MAP3K60.47504528
117CDK60.47285173
118MATK0.46888231
119CAMK1D0.46692299
120NEK10.46349681
121GRK10.46295162
122STK380.45446910
123FGFR10.44923509
124BCKDK0.43832871
125WEE10.41927535
126PLK10.41508964
127CDK70.40119215
128CAMKK10.39737192
129NEK90.39473635
130TBK10.38749155
131MAP3K90.38421590
132CHUK0.37968021
133BMX0.35382424
134KSR20.35372662
135FGFR40.35309288
136MARK30.35260653
137STK40.35169240
138TAOK20.35077236
139MAPK110.34404955
140FYN0.34310130
141AURKA0.34092582
142BCR0.33953464
143TTN0.33618631
144RPS6KA10.33055985
145DDR20.33041001
146BRSK20.32454305
147ZAP700.31899975
148PRKCQ0.31044932
149ILK0.27518772
150MAP3K100.27296451
151TEC0.27108055
152CDK90.22016083
153TGFBR20.21128388
154STK30.18303218
155DYRK30.18060507
156BTK0.17487820

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.22064325
2Ribosome_Homo sapiens_hsa030103.60072174
3Mineral absorption_Homo sapiens_hsa049782.90559568
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.80001110
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72364938
6Sulfur metabolism_Homo sapiens_hsa009202.71792344
7Staphylococcus aureus infection_Homo sapiens_hsa051502.64176341
8Glutathione metabolism_Homo sapiens_hsa004802.44625926
9Graft-versus-host disease_Homo sapiens_hsa053322.37213515
10Vitamin digestion and absorption_Homo sapiens_hsa049772.30312244
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.28679532
12Allograft rejection_Homo sapiens_hsa053302.24186246
13Histidine metabolism_Homo sapiens_hsa003402.19609704
14Lysosome_Homo sapiens_hsa041422.19320754
15* Osteoclast differentiation_Homo sapiens_hsa043802.18538582
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.10906217
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08037995
18Folate biosynthesis_Homo sapiens_hsa007902.06795198
19Arachidonic acid metabolism_Homo sapiens_hsa005902.04061090
20Protein digestion and absorption_Homo sapiens_hsa049741.97479730
21Autoimmune thyroid disease_Homo sapiens_hsa053201.96809467
22Bladder cancer_Homo sapiens_hsa052191.95596515
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92095044
24Renin-angiotensin system_Homo sapiens_hsa046141.87765361
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.86309944
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85940953
27Linoleic acid metabolism_Homo sapiens_hsa005911.85420983
28Type I diabetes mellitus_Homo sapiens_hsa049401.80866463
29* Tuberculosis_Homo sapiens_hsa051521.76789158
30* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73959159
31Tight junction_Homo sapiens_hsa045301.69620996
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68413602
33Rheumatoid arthritis_Homo sapiens_hsa053231.67908802
34Fructose and mannose metabolism_Homo sapiens_hsa000511.66343691
35Galactose metabolism_Homo sapiens_hsa000521.65452420
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.60970713
37Antigen processing and presentation_Homo sapiens_hsa046121.60928574
38Asthma_Homo sapiens_hsa053101.58059425
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55718246
40* Leukocyte transendothelial migration_Homo sapiens_hsa046701.52362388
41Pentose phosphate pathway_Homo sapiens_hsa000301.46991751
42Pancreatic secretion_Homo sapiens_hsa049721.46809782
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39692524
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36326849
45Sphingolipid metabolism_Homo sapiens_hsa006001.32392861
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30510230
47* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30079140
48Malaria_Homo sapiens_hsa051441.29204023
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27862243
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27196243
51Adherens junction_Homo sapiens_hsa045201.23394889
52Caffeine metabolism_Homo sapiens_hsa002321.22763738
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21123478
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20972988
55p53 signaling pathway_Homo sapiens_hsa041151.19966128
56B cell receptor signaling pathway_Homo sapiens_hsa046621.19462269
57Phagosome_Homo sapiens_hsa041451.11774836
58Chemokine signaling pathway_Homo sapiens_hsa040621.09570171
59* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08218119
60African trypanosomiasis_Homo sapiens_hsa051431.07737818
61* T cell receptor signaling pathway_Homo sapiens_hsa046601.06986402
62Primary immunodeficiency_Homo sapiens_hsa053401.04255243
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.00298150
64Measles_Homo sapiens_hsa051620.99088073
65Sulfur relay system_Homo sapiens_hsa041220.98376298
66Glycerolipid metabolism_Homo sapiens_hsa005610.97813816
67Acute myeloid leukemia_Homo sapiens_hsa052210.97414731
68Chemical carcinogenesis_Homo sapiens_hsa052040.96722689
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95033439
70Retinol metabolism_Homo sapiens_hsa008300.94717640
71* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94495295
72Thyroid cancer_Homo sapiens_hsa052160.92384888
73Arginine and proline metabolism_Homo sapiens_hsa003300.88898266
74Starch and sucrose metabolism_Homo sapiens_hsa005000.88756459
75Complement and coagulation cascades_Homo sapiens_hsa046100.88463402
76Herpes simplex infection_Homo sapiens_hsa051680.86716748
77Fatty acid degradation_Homo sapiens_hsa000710.86424157
78Proteasome_Homo sapiens_hsa030500.86224088
79Other glycan degradation_Homo sapiens_hsa005110.85441123
80Collecting duct acid secretion_Homo sapiens_hsa049660.84126943
81Small cell lung cancer_Homo sapiens_hsa052220.83651866
82* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83598682
83PPAR signaling pathway_Homo sapiens_hsa033200.81455989
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81385254
85Legionellosis_Homo sapiens_hsa051340.81267817
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.79693573
87Viral myocarditis_Homo sapiens_hsa054160.79691903
88* Hepatitis C_Homo sapiens_hsa051600.79250651
89Oxidative phosphorylation_Homo sapiens_hsa001900.75814402
90DNA replication_Homo sapiens_hsa030300.72206383
91Parkinsons disease_Homo sapiens_hsa050120.71488705
92Hippo signaling pathway_Homo sapiens_hsa043900.71184446
93Thyroid hormone synthesis_Homo sapiens_hsa049180.70577004
94Ether lipid metabolism_Homo sapiens_hsa005650.69720597
95Fatty acid biosynthesis_Homo sapiens_hsa000610.68202674
96Insulin resistance_Homo sapiens_hsa049310.67118203
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65966622
98Pyrimidine metabolism_Homo sapiens_hsa002400.65655514
99ECM-receptor interaction_Homo sapiens_hsa045120.64672203
100Vibrio cholerae infection_Homo sapiens_hsa051100.64600090
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.63572626
102Hepatitis B_Homo sapiens_hsa051610.63298526
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62956753
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61679361
105* Influenza A_Homo sapiens_hsa051640.61449684
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60508038
107Mismatch repair_Homo sapiens_hsa034300.58708678
108Endocytosis_Homo sapiens_hsa041440.57380419
109Alzheimers disease_Homo sapiens_hsa050100.57280029
110* VEGF signaling pathway_Homo sapiens_hsa043700.56738319
111Apoptosis_Homo sapiens_hsa042100.56601777
112Huntingtons disease_Homo sapiens_hsa050160.56583376
113beta-Alanine metabolism_Homo sapiens_hsa004100.55918518
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54321083
115* Prolactin signaling pathway_Homo sapiens_hsa049170.52059949
116* Sphingolipid signaling pathway_Homo sapiens_hsa040710.51519024
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50565880
118Bile secretion_Homo sapiens_hsa049760.49428130
119Notch signaling pathway_Homo sapiens_hsa043300.48307518
120Carbon metabolism_Homo sapiens_hsa012000.48233466
121Amoebiasis_Homo sapiens_hsa051460.47809807
122Homologous recombination_Homo sapiens_hsa034400.46649339
123* Shigellosis_Homo sapiens_hsa051310.46228365
124Tryptophan metabolism_Homo sapiens_hsa003800.46000805
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45178326
126Basal cell carcinoma_Homo sapiens_hsa052170.44840980
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42480613
128* GnRH signaling pathway_Homo sapiens_hsa049120.40469698
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40146234
130* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39314103
131Type II diabetes mellitus_Homo sapiens_hsa049300.39053197
132* Toxoplasmosis_Homo sapiens_hsa051450.39040401
133Cell cycle_Homo sapiens_hsa041100.38947529
134* Salmonella infection_Homo sapiens_hsa051320.37919456
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37878186
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.37580754
137Metabolic pathways_Homo sapiens_hsa011000.36838025
138* Pertussis_Homo sapiens_hsa051330.36380135
139Hematopoietic cell lineage_Homo sapiens_hsa046400.36171484
140* Platelet activation_Homo sapiens_hsa046110.35090083
141RNA polymerase_Homo sapiens_hsa030200.33597250
142* TNF signaling pathway_Homo sapiens_hsa046680.32329861
143Gastric acid secretion_Homo sapiens_hsa049710.30018431
144* Leishmaniasis_Homo sapiens_hsa051400.29774457
145MicroRNAs in cancer_Homo sapiens_hsa052060.27457230
146Pyruvate metabolism_Homo sapiens_hsa006200.26220177
147Phenylalanine metabolism_Homo sapiens_hsa003600.25902248
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.25429699
149* Proteoglycans in cancer_Homo sapiens_hsa052050.24608821
150Spliceosome_Homo sapiens_hsa030400.24380812
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23412569
152* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22018057
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21656991
154* NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21290948
155N-Glycan biosynthesis_Homo sapiens_hsa005100.20939427
156ABC transporters_Homo sapiens_hsa020100.20364425

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