MAPK12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)8.75910397
2actin-mediated cell contraction (GO:0070252)8.41359484
3plasma membrane repair (GO:0001778)7.49739135
4sarcoplasmic reticulum calcium ion transport (GO:0070296)7.43524437
5skeletal muscle contraction (GO:0003009)7.39243485
6sarcomere organization (GO:0045214)6.60597409
7actin filament-based movement (GO:0030048)6.42542813
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.22394924
9skeletal muscle adaptation (GO:0043501)6.01871215
10myofibril assembly (GO:0030239)5.80599662
11striated muscle contraction (GO:0006941)5.79419166
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.25622236
13carnitine shuttle (GO:0006853)5.15847112
14skeletal muscle fiber development (GO:0048741)5.06859234
15regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.05021732
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.96816819
17cardiac muscle contraction (GO:0060048)4.86728640
18cardiac myofibril assembly (GO:0055003)4.82535178
19actomyosin structure organization (GO:0031032)4.76886879
20glycogen catabolic process (GO:0005980)4.62258284
21muscle contraction (GO:0006936)4.61974566
22fatty acid transmembrane transport (GO:1902001)4.49684124
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.49327978
24regulation of cell communication by electrical coupling (GO:0010649)4.48165846
25tricarboxylic acid cycle (GO:0006099)4.37181874
26negative regulation of potassium ion transmembrane transport (GO:1901380)4.31963451
27glucan catabolic process (GO:0009251)4.26894541
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.23184284
29myotube cell development (GO:0014904)4.22140302
30muscle system process (GO:0003012)4.10979200
31regulation of skeletal muscle cell differentiation (GO:2001014)4.06171743
32pyrimidine ribonucleoside catabolic process (GO:0046133)4.00823706
33cardiac muscle cell development (GO:0055013)4.00105308
34muscle fiber development (GO:0048747)3.99928153
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.91519238
36regulation of relaxation of muscle (GO:1901077)3.88867823
37cellular polysaccharide catabolic process (GO:0044247)3.84651934
38carnitine transmembrane transport (GO:1902603)3.80495616
39cytidine deamination (GO:0009972)3.79869674
40cytidine metabolic process (GO:0046087)3.79869674
41cytidine catabolic process (GO:0006216)3.79869674
42response to inactivity (GO:0014854)3.79359030
43cardiac cell development (GO:0055006)3.76854827
44creatine metabolic process (GO:0006600)3.76557155
45glucan biosynthetic process (GO:0009250)3.72440054
46glycogen biosynthetic process (GO:0005978)3.72440054
47regulation of actin filament-based movement (GO:1903115)3.71875647
48regulation of translational fidelity (GO:0006450)3.71731261
49striated muscle adaptation (GO:0014888)3.70973449
50IMP metabolic process (GO:0046040)3.64639400
51response to muscle activity (GO:0014850)3.61518398
52polysaccharide catabolic process (GO:0000272)3.60784950
53negative regulation of cell size (GO:0045792)3.60677985
54striated muscle atrophy (GO:0014891)3.59561078
55skeletal muscle tissue regeneration (GO:0043403)3.59437248
56striated muscle cell development (GO:0055002)3.58992308
57cardiac muscle tissue morphogenesis (GO:0055008)3.57430409
58muscle tissue morphogenesis (GO:0060415)3.54305524
59regulation of striated muscle contraction (GO:0006942)3.47323609
60glycogen metabolic process (GO:0005977)3.47110299
61purine nucleotide salvage (GO:0032261)3.46591371
62regulation of acyl-CoA biosynthetic process (GO:0050812)3.45778207
63amino-acid betaine transport (GO:0015838)3.44420427
64carnitine transport (GO:0015879)3.44420427
65muscle cell fate commitment (GO:0042693)3.39937479
66regulation of cofactor metabolic process (GO:0051193)3.39241249
67regulation of coenzyme metabolic process (GO:0051196)3.39241249
68cellular glucan metabolic process (GO:0006073)3.38431091
69glucan metabolic process (GO:0044042)3.38431091
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.37607396
712-oxoglutarate metabolic process (GO:0006103)3.31920023
72muscle cell cellular homeostasis (GO:0046716)3.29917287
73gluconeogenesis (GO:0006094)3.24354627
74heart contraction (GO:0060047)3.23296763
75heart process (GO:0003015)3.23296763
76skeletal muscle tissue development (GO:0007519)3.23125376
77heart trabecula formation (GO:0060347)3.22710876
78positive regulation of myotube differentiation (GO:0010831)3.19542919
79muscle cell development (GO:0055001)3.18600825
80myoblast fusion (GO:0007520)3.16679487
81regulation of membrane repolarization (GO:0060306)3.14754384
82IMP biosynthetic process (GO:0006188)3.11177967
83regulation of cardioblast proliferation (GO:0003264)3.07513424
84regulation of secondary heart field cardioblast proliferation (GO:0003266)3.07513424
85muscle organ morphogenesis (GO:0048644)3.07205551
86regulation of calcium ion transmembrane transporter activity (GO:1901019)3.04317470
87regulation of calcium ion transmembrane transport (GO:1903169)3.04317470
88negative regulation of muscle hypertrophy (GO:0014741)3.03909058
89* muscle organ development (GO:0007517)3.03458992
90striated muscle hypertrophy (GO:0014897)3.03337621
91paraxial mesoderm development (GO:0048339)3.02307793
92neuromuscular synaptic transmission (GO:0007274)3.00092092
93* muscle structure development (GO:0061061)2.99443587
94oxidative phosphorylation (GO:0006119)2.98851410
95cardiac muscle hypertrophy (GO:0003300)2.95841219
96positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.94562154
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94067144
98NADH metabolic process (GO:0006734)2.93645610
99lymph vessel development (GO:0001945)2.93521800
100ubiquinone biosynthetic process (GO:0006744)2.92648969
101muscle adaptation (GO:0043500)2.92249385
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90458035
103regulation of p38MAPK cascade (GO:1900744)2.89752829
104hexose biosynthetic process (GO:0019319)2.89325782
105bundle of His cell to Purkinje myocyte communication (GO:0086069)2.89056696
106ventricular cardiac muscle cell action potential (GO:0086005)2.88146637
107neuronal action potential propagation (GO:0019227)2.87448255
108muscle atrophy (GO:0014889)2.86562071
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86426345
110regulation of muscle contraction (GO:0006937)2.85463090
111ribosomal small subunit biogenesis (GO:0042274)2.82200662
112proline biosynthetic process (GO:0006561)2.80032482
113cell-substrate adherens junction assembly (GO:0007045)2.75626192
114focal adhesion assembly (GO:0048041)2.75626192
115mitochondrial fusion (GO:0008053)2.75149791
116mitochondrion transport along microtubule (GO:0047497)2.72781575
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72781575
118cranial nerve morphogenesis (GO:0021602)2.71922610
119monosaccharide biosynthetic process (GO:0046364)2.59585096
120positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58191390
121kidney mesenchyme development (GO:0072074)2.54971394
122positive regulation of synapse maturation (GO:0090129)2.54939274
123convergent extension (GO:0060026)2.53847825
124mitochondrial genome maintenance (GO:0000002)2.52729381
125ubiquinone metabolic process (GO:0006743)2.52552987
126negative regulation of cell cycle G2/M phase transition (GO:1902750)2.48361450
127AMP metabolic process (GO:0046033)2.47616006
128adherens junction assembly (GO:0034333)2.47545324
129cochlea morphogenesis (GO:0090103)2.44113999
130negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.42400363
131DNA unwinding involved in DNA replication (GO:0006268)2.40094327
132regulation of mammary gland epithelial cell proliferation (GO:0033599)2.38753819
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38697531
134regulation of the force of heart contraction (GO:0002026)2.38209656
135DNA replication checkpoint (GO:0000076)2.37666076
136adult heart development (GO:0007512)2.35132713
137DNA replication initiation (GO:0006270)2.33927776
138striated muscle tissue development (GO:0014706)2.33915136
139regulation of myotube differentiation (GO:0010830)2.32725271
140muscle filament sliding (GO:0030049)10.0541625
141actin-myosin filament sliding (GO:0033275)10.0541625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.41969513
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27736916
3ZNF263_19887448_ChIP-Seq_K562_Human3.13391735
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.08367705
5E2F7_22180533_ChIP-Seq_HELA_Human3.03232415
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.00758831
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82135532
8CLOCK_20551151_ChIP-Seq_293T_Human2.71552800
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.68193324
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53459352
11VDR_21846776_ChIP-Seq_THP-1_Human2.49742157
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.46286606
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.46286606
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38463627
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.38416231
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24267498
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18464487
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.18109490
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08772124
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05799988
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05587720
22XRN2_22483619_ChIP-Seq_HELA_Human2.01934050
23CREB1_26743006_Chip-Seq_LNCaP-abl_Human2.01650912
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.01199650
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00421963
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95926288
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92976239
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91462114
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.91292562
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90508425
31MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.90380030
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.88758006
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.83674280
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.81084636
35KDM2B_26808549_Chip-Seq_DND41_Human1.75931168
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75871925
37CTCF_27219007_Chip-Seq_Bcells_Human1.68747536
38RACK7_27058665_Chip-Seq_MCF-7_Human1.68551070
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68348705
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.67667593
41ZNF274_21170338_ChIP-Seq_K562_Hela1.66621153
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64250844
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62575726
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61987379
45LXR_22292898_ChIP-Seq_THP-1_Human1.60807490
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58399616
47* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58276894
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57098513
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.55884428
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55672667
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55583027
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53164381
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50858706
54* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49857163
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49251860
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48280628
57CREB1_26743006_Chip-Seq_LNCaP_Human1.47497467
58ATF3_27146783_Chip-Seq_COLON_Human1.46570972
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.46349735
60KDM2B_26808549_Chip-Seq_K562_Human1.45789397
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44161368
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43549084
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42648073
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42247852
65SMC4_20622854_ChIP-Seq_HELA_Human1.41511940
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40520084
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.39616546
68GATA4_21415370_ChIP-Seq_HL-1_Mouse1.39506920
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39222420
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36073526
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35145929
72EZH2_22144423_ChIP-Seq_EOC_Human1.34895138
73CTCF_26484167_Chip-Seq_Bcells_Mouse1.34850883
74RARA_24833708_ChIP-Seq_LIVER_Mouse1.34674100
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.34399688
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34067497
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33989335
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33050058
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31984880
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31683842
81P68_20966046_ChIP-Seq_HELA_Human1.31177436
82* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30673572
83TP53_22127205_ChIP-Seq_IMR90_Human1.30583068
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29915996
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.29802492
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29039112
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.28826153
88GABP_19822575_ChIP-Seq_HepG2_Human1.28340837
89CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27800172
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25716945
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25582168
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24506078
93PHF8_20622854_ChIP-Seq_HELA_Human1.23559748
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23410755
95DCP1A_22483619_ChIP-Seq_HELA_Human1.23027582
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21930095
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20651373
98* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20583743
99SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19310680
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17689480
101TTF2_22483619_ChIP-Seq_HELA_Human1.17531128
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.17465578
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17340358
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17203997
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15549178
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.15283459
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14702843
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13958764
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13930839
110TBX5_21415370_ChIP-Seq_HL-1_Mouse1.13891531
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13795401
112SA1_27219007_Chip-Seq_Bcells_Human1.13213493
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13121514
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12932973
115RARB_24833708_ChIP-Seq_LIVER_Mouse1.12549891
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.12383983
117CIITA_25753668_ChIP-Seq_RAJI_Human1.12282050
118ISL1_27105846_Chip-Seq_CPCs_Mouse1.12272267
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10894269
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10281729
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09625348
122MYC_22102868_ChIP-Seq_BL_Human1.09325263
123CTCF_21964334_Chip-Seq_Bcells_Human1.08743833
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07734456
125BCOR_27268052_Chip-Seq_Bcells_Human1.07291345
126BCL6_27268052_Chip-Seq_Bcells_Human1.07178594
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06485661
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.06270805
129CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05397295
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05117248
131RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04592612
132TCF7_22412390_ChIP-Seq_EML_Mouse1.03583218
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00802969
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00676249
135OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00518909
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99576100
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99148969
138TP63_22573176_ChIP-Seq_HFKS_Human0.99106475
139EZH2_27294783_Chip-Seq_ESCs_Mouse0.98470867
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96522559
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.95256786
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95219339
143SPI1_20517297_ChIP-Seq_HL60_Human0.94293490
144WT1_19549856_ChIP-ChIP_CCG9911_Human0.94223605
145FOXP1_21924763_ChIP-Seq_HESCs_Human0.91950802
146* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91665917
147* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91665917
148* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91317376
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.90704338
150E2F1_20622854_ChIP-Seq_HELA_Human0.90700649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.26130737
2MP0000749_muscle_degeneration5.47363658
3MP0000751_myopathy5.27966095
4MP0003646_muscle_fatigue4.95409489
5MP0004036_abnormal_muscle_relaxation4.02706530
6MP0002837_dystrophic_cardiac_calcinosis3.75997627
7MP0000747_muscle_weakness3.54260503
8MP0004084_abnormal_cardiac_muscle3.43273345
9MP0002106_abnormal_muscle_physiology3.31028415
10MP0004087_abnormal_muscle_fiber3.26800758
11MP0000759_abnormal_skeletal_muscle3.17663617
12MP0005451_abnormal_body_composition3.17479591
13MP0002269_muscular_atrophy3.12041692
14MP0000750_abnormal_muscle_regeneration2.93202834
15MP0005620_abnormal_muscle_contractility2.85153096
16MP0005369_muscle_phenotype2.72994945
17MP0004233_abnormal_muscle_weight2.51637028
18MP0004130_abnormal_muscle_cell2.49506946
19MP0005330_cardiomyopathy2.40516645
20MP0004215_abnormal_myocardial_fiber2.38667097
21MP0002332_abnormal_exercise_endurance2.15534597
22MP0010368_abnormal_lymphatic_system2.06430143
23MP0000733_abnormal_muscle_development2.00017751
24MP0010630_abnormal_cardiac_muscle1.87336133
25MP0002972_abnormal_cardiac_muscle1.85969114
26MP0010030_abnormal_orbit_morphology1.78032519
27MP0002234_abnormal_pharynx_morphology1.77725995
28MP0003705_abnormal_hypodermis_morpholog1.68623184
29MP0004484_altered_response_of1.68141945
30MP0001661_extended_life_span1.64696110
31MP0001544_abnormal_cardiovascular_syste1.56588388
32MP0005385_cardiovascular_system_phenoty1.56588388
33MP0001879_abnormal_lymphatic_vessel1.56112456
34MP0002108_abnormal_muscle_morphology1.44541096
35MP0008775_abnormal_heart_ventricle1.42082825
36MP0006138_congestive_heart_failure1.33219217
37MP0003137_abnormal_impulse_conducting1.28062678
38MP0002653_abnormal_ependyma_morphology1.27554848
39MP0003950_abnormal_plasma_membrane1.25837320
40* MP0006036_abnormal_mitochondrial_physio1.24446331
41MP0005666_abnormal_adipose_tissue1.23568281
42MP0001346_abnormal_lacrimal_gland1.23339254
43MP0004185_abnormal_adipocyte_glucose1.21536921
44MP0003111_abnormal_nucleus_morphology1.20457892
45MP0008438_abnormal_cutaneous_collagen1.19443934
46MP0003828_pulmonary_edema1.18288197
47MP0004085_abnormal_heartbeat1.16898714
48MP0003221_abnormal_cardiomyocyte_apopto1.13377130
49MP0002127_abnormal_cardiovascular_syste1.08569044
50MP0004147_increased_porphyrin_level1.08532370
51MP0004272_abnormal_basement_membrane1.06996771
52MP0002971_abnormal_brown_adipose1.03953717
53MP0000266_abnormal_heart_morphology1.02548092
54MP0010094_abnormal_chromosome_stability0.98797312
55MP0000013_abnormal_adipose_tissue0.97873322
56MP0005375_adipose_tissue_phenotype0.97032195
57MP0005670_abnormal_white_adipose0.95516606
58MP0000537_abnormal_urethra_morphology0.94865256
59MP0005167_abnormal_blood-brain_barrier0.94576946
60MP0009384_cardiac_valve_regurgitation0.91826490
61MP0008789_abnormal_olfactory_epithelium0.84175658
62MP0001299_abnormal_eye_distance/0.83788714
63MP0005266_abnormal_metabolism0.83592204
64MP0005083_abnormal_biliary_tract0.81241212
65MP0003279_aneurysm0.80213840
66MP0000049_abnormal_middle_ear0.79738153
67MP0003567_abnormal_fetal_cardiomyocyte0.78684818
68MP0002822_catalepsy0.75321378
69MP0000534_abnormal_ureter_morphology0.75176024
70MP0005187_abnormal_penis_morphology0.74667687
71MP0004270_analgesia0.74109170
72MP0004859_abnormal_synaptic_plasticity0.73570005
73MP0001348_abnormal_lacrimal_gland0.72918946
74MP0000003_abnormal_adipose_tissue0.69812598
75MP0002128_abnormal_blood_circulation0.68748467
76MP0000762_abnormal_tongue_morphology0.68056372
77MP0000678_abnormal_parathyroid_gland0.67623330
78MP0005423_abnormal_somatic_nervous0.67424766
79MP0009672_abnormal_birth_weight0.67229278
80MP0003385_abnormal_body_wall0.67205191
81MP0003806_abnormal_nucleotide_metabolis0.66983147
82MP0008007_abnormal_cellular_replicative0.65715683
83MP0001502_abnormal_circadian_rhythm0.64995105
84MP0009379_abnormal_foot_pigmentation0.63546528
85MP0005171_absent_coat_pigmentation0.62052667
86* MP0002925_abnormal_cardiovascular_devel0.60596355
87MP0001730_embryonic_growth_arrest0.60424961
88MP0004510_myositis0.57909229
89MP0001849_ear_inflammation0.57605696
90MP0005623_abnormal_meninges_morphology0.57456395
91MP0000343_altered_response_to0.56784354
92MP0002116_abnormal_craniofacial_bone0.56584034
93MP0009250_abnormal_appendicular_skeleto0.56546411
94MP0006035_abnormal_mitochondrial_morpho0.55570408
95MP0009780_abnormal_chondrocyte_physiolo0.55192709
96MP0003786_premature_aging0.53910329
97MP0002877_abnormal_melanocyte_morpholog0.53289067
98MP0000230_abnormal_systemic_arterial0.52119403
99MP0005275_abnormal_skin_tensile0.51833579
100MP0003119_abnormal_digestive_system0.51708253
101MP0005076_abnormal_cell_differentiation0.51609929
102MP0001270_distended_abdomen0.50574278
103MP0000767_abnormal_smooth_muscle0.50531828
104MP0008932_abnormal_embryonic_tissue0.50451704
105MP0003283_abnormal_digestive_organ0.50181447
106MP0003122_maternal_imprinting0.49887672
107MP0008961_abnormal_basal_metabolism0.49879009
108MP0002177_abnormal_outer_ear0.49737781
109MP0006292_abnormal_olfactory_placode0.49563756
110MP0000428_abnormal_craniofacial_morphol0.49194630
111MP0003077_abnormal_cell_cycle0.48864471
112MP0005409_darkened_coat_color0.48592310
113MP0001943_abnormal_respiration0.48589596
114MP0005503_abnormal_tendon_morphology0.48379965
115MP0004134_abnormal_chest_morphology0.48233526
116MP0003315_abnormal_perineum_morphology0.47903146
117MP0002081_perinatal_lethality0.47732345
118MP0003566_abnormal_cell_adhesion0.47511338
119MP0004133_heterotaxia0.46742321
120MP0008569_lethality_at_weaning0.45332946
121* MP0001614_abnormal_blood_vessel0.44802677
122MP0002089_abnormal_postnatal_growth/wei0.44655340
123MP0004197_abnormal_fetal_growth/weight/0.44514519
124MP0005499_abnormal_olfactory_system0.44194450
125MP0005394_taste/olfaction_phenotype0.44194450
126MP0002909_abnormal_adrenal_gland0.41828602
127MP0004043_abnormal_pH_regulation0.39465198
128MP0002233_abnormal_nose_morphology0.38892274
129MP0003942_abnormal_urinary_system0.38825702
130MP0002114_abnormal_axial_skeleton0.38750026
131MP0004858_abnormal_nervous_system0.37938293
132MP0003984_embryonic_growth_retardation0.37727684
133MP0002932_abnormal_joint_morphology0.37720536
134MP0002249_abnormal_larynx_morphology0.37680538

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.48224426
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.10200307
3Nemaline bodies (HP:0003798)7.61886336
4Exercise-induced myalgia (HP:0003738)7.60687246
5Exercise-induced muscle cramps (HP:0003710)7.42374607
6Type 1 muscle fiber predominance (HP:0003803)6.53576471
7Muscle hypertrophy of the lower extremities (HP:0008968)6.40721579
8Distal arthrogryposis (HP:0005684)6.06499991
9Calf muscle hypertrophy (HP:0008981)6.03510978
10Muscle fiber splitting (HP:0003555)5.20977890
11Myoglobinuria (HP:0002913)5.20479357
12Myopathic facies (HP:0002058)5.17982567
13Hyporeflexia of lower limbs (HP:0002600)5.10343612
14Difficulty running (HP:0009046)4.99351898
15Round ear (HP:0100830)4.99341047
16Ulnar deviation of the wrist (HP:0003049)4.70957662
17Increased connective tissue (HP:0009025)4.63164115
18Muscle stiffness (HP:0003552)4.52142963
19EMG: myopathic abnormalities (HP:0003458)4.49826006
20Myotonia (HP:0002486)4.41075566
21Abnormality of the calf musculature (HP:0001430)4.35987422
22Rhabdomyolysis (HP:0003201)4.30308931
23Calcaneovalgus deformity (HP:0001848)4.12196646
24Sudden death (HP:0001699)3.99267142
25Absent phalangeal crease (HP:0006109)3.80951148
26Deformed tarsal bones (HP:0008119)3.75167907
27Subaortic stenosis (HP:0001682)3.73318575
28Abnormality of the left ventricular outflow tract (HP:0011103)3.73318575
29Abnormality of skeletal muscle fiber size (HP:0012084)3.67162146
30Difficulty climbing stairs (HP:0003551)3.42231476
31Increased variability in muscle fiber diameter (HP:0003557)3.41247144
32Rimmed vacuoles (HP:0003805)3.39165734
33Neck muscle weakness (HP:0000467)3.30321759
34Abnormal finger flexion creases (HP:0006143)3.12659586
35Areflexia of lower limbs (HP:0002522)3.10445999
36Ventricular tachycardia (HP:0004756)2.98517662
37Asymmetric septal hypertrophy (HP:0001670)2.96755244
38Distal lower limb muscle weakness (HP:0009053)2.95732866
39EMG: neuropathic changes (HP:0003445)2.86705338
40Shoulder girdle muscle weakness (HP:0003547)2.79604809
41Pelvic girdle muscle weakness (HP:0003749)2.78812955
42Malignant hyperthermia (HP:0002047)2.71993940
43Abnormality of the hip-girdle musculature (HP:0001445)2.69698731
44Abnormality of the musculature of the pelvis (HP:0001469)2.69698731
45Frequent falls (HP:0002359)2.66118524
46Abnormality of the calcaneus (HP:0008364)2.65256059
47Stridor (HP:0010307)2.48679606
48Limb-girdle muscle atrophy (HP:0003797)2.43499558
49Lipoatrophy (HP:0100578)2.41708854
50Spinal rigidity (HP:0003306)2.39538761
51Scapular winging (HP:0003691)2.37174050
52Generalized muscle weakness (HP:0003324)2.32710243
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.31971076
54Ragged-red muscle fibers (HP:0003200)2.31468848
55Hyperkalemia (HP:0002153)2.29670665
56Muscular dystrophy (HP:0003560)2.29182964
57Lower limb amyotrophy (HP:0007210)2.27419278
58Mildly elevated creatine phosphokinase (HP:0008180)2.26894125
59Right ventricular cardiomyopathy (HP:0011663)2.25455430
60Progressive muscle weakness (HP:0003323)2.23559948
61Proximal amyotrophy (HP:0007126)2.22676948
62Dilated cardiomyopathy (HP:0001644)2.22183877
63Limb-girdle muscle weakness (HP:0003325)2.18718714
64Abnormality of the shoulder girdle musculature (HP:0001435)2.16337567
65Atrial fibrillation (HP:0005110)2.11851467
66Fatigable weakness (HP:0003473)2.03177896
67Abnormality of the neuromuscular junction (HP:0003398)2.03177896
68Facial diplegia (HP:0001349)2.03149637
69Ulnar bowing (HP:0003031)2.02583723
70Bundle branch block (HP:0011710)2.02166489
71Gowers sign (HP:0003391)2.00143161
72Primary atrial arrhythmia (HP:0001692)1.99333365
73Foot dorsiflexor weakness (HP:0009027)1.97974050
74Abnormality of the foot musculature (HP:0001436)1.96653845
75Bulbar palsy (HP:0001283)1.94603517
76Supraventricular tachycardia (HP:0004755)1.92312587
77Supraventricular arrhythmia (HP:0005115)1.91873060
78Protrusio acetabuli (HP:0003179)1.91611398
79Slender build (HP:0001533)1.90280573
80Palpitations (HP:0001962)1.90127946
81Weak cry (HP:0001612)1.89177024
82Hyperacusis (HP:0010780)1.84791440
83Hypoplastic ischia (HP:0003175)1.84062843
84Broad metatarsal (HP:0001783)1.83290442
85Metatarsus adductus (HP:0001840)1.83261520
86Fetal akinesia sequence (HP:0001989)1.81231738
87Ventricular arrhythmia (HP:0004308)1.80741508
88Achilles tendon contracture (HP:0001771)1.79157491
89Hip contracture (HP:0003273)1.77890401
90Paralysis (HP:0003470)1.77691133
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75092536
92Waddling gait (HP:0002515)1.72805252
93Adducted thumb (HP:0001181)1.70813047
94Ulnar deviation of finger (HP:0009465)1.69635390
95Heart block (HP:0012722)1.67529795
96Generalized amyotrophy (HP:0003700)1.66811678
97Nonprogressive disorder (HP:0003680)1.65028172
98Abnormality of the ischium (HP:0003174)1.63612314
99Distal lower limb amyotrophy (HP:0008944)1.63443961
100Prolonged QT interval (HP:0001657)1.62956146
101Abnormality of the Achilles tendon (HP:0005109)1.62519155
102Short palpebral fissure (HP:0012745)1.62314581
103Respiratory insufficiency due to muscle weakness (HP:0002747)1.61444154
104Tarsal synostosis (HP:0008368)1.61339783
105Abnormal atrioventricular conduction (HP:0005150)1.60820294
106Thin ribs (HP:0000883)1.59823708
107Severe muscular hypotonia (HP:0006829)1.58369956
108Slender long bone (HP:0003100)1.55006581
109Ventricular fibrillation (HP:0001663)1.52850865
110Increased intramyocellular lipid droplets (HP:0012240)1.52399211
111Increased muscle lipid content (HP:0009058)1.51423121
112Limited hip movement (HP:0008800)1.50785462
113Premature rupture of membranes (HP:0001788)1.50134170
114Exercise intolerance (HP:0003546)1.48740677
115Congenital hip dislocation (HP:0001374)1.47839197
116Wrist flexion contracture (HP:0001239)1.47749167
117Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.47401440
118Synostosis involving bones of the feet (HP:0009140)1.46425097
119Synostosis involving bones of the lower limbs (HP:0009138)1.46425097
120Hyperthyroidism (HP:0000836)1.44464474
121Testicular atrophy (HP:0000029)1.43382851
122Rectal prolapse (HP:0002035)1.42831735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.48182263
2TTN6.12627547
3PHKG14.58445619
4PHKG24.58445619
5TIE13.13481497
6NEK12.62567714
7TRIB32.36017580
8PIK3CG2.34261078
9NME12.20708084
10BCKDK2.17676582
11CDK192.13497065
12PKN21.95692366
13KDR1.78379076
14RIPK11.70400970
15PDK41.68779186
16PDK31.68779186
17DMPK1.64642285
18PINK11.59295029
19MAP3K71.56943156
20EPHB21.50269263
21MAP3K101.45989747
22NME21.41926532
23SMG11.41033574
24IRAK31.33888171
25MAPKAPK31.32631102
26PIK3CA1.24174196
27TGFBR11.23683876
28TLK11.21872294
29PTK61.21343279
30NTRK11.18600621
31PDK21.15618428
32MAP3K31.09104929
33PRKD31.08408367
34LMTK21.08173228
35MYLK1.04856577
36LATS21.03244183
37CCNB11.01585276
38* MAP2K31.01532288
39MAP3K111.00981830
40ILK0.96296969
41MUSK0.89906627
42CDK80.89620200
43BRAF0.85584854
44ARAF0.84924660
45LRRK20.82754199
46MARK10.81957448
47EEF2K0.81642185
48MAP3K130.81088903
49PRKD20.78536786
50AKT20.77276373
51CDK120.75152101
52KSR20.74187744
53PNCK0.73334683
54NEK90.71969545
55TGFBR20.68185765
56TAOK20.67749985
57MET0.67707914
58LIMK10.65851155
59CDC70.65599827
60MOS0.64395732
61PAK60.63923888
62RPS6KA20.63621898
63STK240.62481772
64CAMK1G0.61666880
65WNK40.61517683
66CHEK20.59237608
67DYRK1B0.59193594
68PRKAA10.58930519
69PDPK10.58752383
70MARK20.57259924
71PAK40.56463333
72FER0.55424972
73* MAPK120.55376674
74PRKAA20.54014886
75RPS6KB20.53733179
76TAOK10.53672618
77FGFR10.53332154
78PIM20.53117907
79MAP2K10.52372682
80MAP3K10.52322708
81PKN10.50717117
82BUB10.50569859
83RPS6KL10.49822045
84RPS6KC10.49822045
85PTK2B0.48678520
86PTK20.48593793
87NEK20.47073880
88TRPM70.46354112
89PAK20.45515538
90RPS6KA60.45465592
91PDGFRA0.45385540
92PRKD10.45189998
93MAP3K60.45125125
94ZAK0.43381254
95STK38L0.42847714
96ROCK10.42607269
97CHEK10.42373140
98FLT30.42259722
99CAMK10.42162498
100WNK10.41994210
101CAMK2G0.41881527
102ATR0.40243594
103STK380.39759199
104DAPK30.39446915
105PRKACB0.38159882
106CAMKK20.38086622
107MAPK150.37672974
108RET0.37150042
109CDK40.37012429
110MTOR0.35877450
111MAPK40.35857159
112ERN10.35800454
113LATS10.35741310
114EIF2AK10.35031886
115ROCK20.34712071
116MAP2K20.34206826
117MAPKAPK50.33561921
118* CDK20.33122308
119DAPK20.33120992
120CAMK1D0.32648635
121CDK10.32169658
122SIK20.30883738
123MAPK100.30674255
124MAP3K40.30074551
125BRSK10.29095742
126CAMK2B0.29034096
127PRKCI0.28423856
128MAPK80.27296716
129CDK90.26383923
130ERBB30.25818933
131MAP3K50.24739329
132SCYL20.24423089
133CAMK40.23353634
134CDC42BPA0.23292283
135SIK10.22017959
136MAPK110.19962346
137MAP3K80.19339141
138PRKACA0.18388429
139MINK10.18070751
140CAMK2D0.17932878
141ICK0.17737588
142CDK60.17699080
143* MAP2K40.15929401
144SGK30.15901183
145RPS6KA30.15670203
146MAP3K90.13765090
147PRKG10.12821306
148CSNK1E0.11705861
149KSR10.10360273
150AURKA0.09880189
151MAPK90.09640735
152PRKCH0.09495886
153RPS6KA10.09333169

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.90264304
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.79816869
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.69439624
4Cardiac muscle contraction_Homo sapiens_hsa042603.60356540
5Dilated cardiomyopathy_Homo sapiens_hsa054143.35946194
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.05192333
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37586523
8Propanoate metabolism_Homo sapiens_hsa006402.30112499
9Carbon metabolism_Homo sapiens_hsa012002.27525657
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.06788100
11* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91098990
12Glucagon signaling pathway_Homo sapiens_hsa049221.90088484
13DNA replication_Homo sapiens_hsa030301.88918441
14Insulin signaling pathway_Homo sapiens_hsa049101.72713034
15Parkinsons disease_Homo sapiens_hsa050121.68143832
16Starch and sucrose metabolism_Homo sapiens_hsa005001.67217161
17Biosynthesis of amino acids_Homo sapiens_hsa012301.65078624
18Fatty acid degradation_Homo sapiens_hsa000711.62573717
19Insulin resistance_Homo sapiens_hsa049311.62274657
20Tight junction_Homo sapiens_hsa045301.61002368
21Ribosome_Homo sapiens_hsa030101.57867729
22Pyruvate metabolism_Homo sapiens_hsa006201.56497448
23Oxytocin signaling pathway_Homo sapiens_hsa049211.55781774
24Circadian rhythm_Homo sapiens_hsa047101.47226922
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44474714
26Base excision repair_Homo sapiens_hsa034101.35014349
27Alzheimers disease_Homo sapiens_hsa050101.30267905
28AMPK signaling pathway_Homo sapiens_hsa041521.29208936
29Oxidative phosphorylation_Homo sapiens_hsa001901.28733587
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.28194450
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.23458136
32Calcium signaling pathway_Homo sapiens_hsa040201.21874514
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19951547
34Focal adhesion_Homo sapiens_hsa045101.19604954
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18008644
36One carbon pool by folate_Homo sapiens_hsa006701.17708835
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16613886
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15470996
39Galactose metabolism_Homo sapiens_hsa000521.15090298
40Fatty acid metabolism_Homo sapiens_hsa012121.14200174
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13370748
42Viral myocarditis_Homo sapiens_hsa054161.12684407
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11055332
44Other glycan degradation_Homo sapiens_hsa005111.08871676
45Nucleotide excision repair_Homo sapiens_hsa034201.06798719
46Adherens junction_Homo sapiens_hsa045201.01968829
47Fructose and mannose metabolism_Homo sapiens_hsa000511.01085440
48Pyrimidine metabolism_Homo sapiens_hsa002400.98836598
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.95156508
50Glioma_Homo sapiens_hsa052140.94884608
51Sulfur relay system_Homo sapiens_hsa041220.94399439
52HIF-1 signaling pathway_Homo sapiens_hsa040660.92736440
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92580417
54Huntingtons disease_Homo sapiens_hsa050160.92369689
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.89152934
56Fanconi anemia pathway_Homo sapiens_hsa034600.88162033
57Arginine biosynthesis_Homo sapiens_hsa002200.87662924
58Homologous recombination_Homo sapiens_hsa034400.84113525
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82174947
60Vitamin B6 metabolism_Homo sapiens_hsa007500.81750452
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81305164
62Purine metabolism_Homo sapiens_hsa002300.81044056
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76622123
64RNA polymerase_Homo sapiens_hsa030200.76575912
65mRNA surveillance pathway_Homo sapiens_hsa030150.76234834
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76044284
67Gastric acid secretion_Homo sapiens_hsa049710.75543557
68Basal cell carcinoma_Homo sapiens_hsa052170.74649904
69Hippo signaling pathway_Homo sapiens_hsa043900.74155450
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72773407
71Hedgehog signaling pathway_Homo sapiens_hsa043400.71731780
72Arginine and proline metabolism_Homo sapiens_hsa003300.71621988
73* Proteoglycans in cancer_Homo sapiens_hsa052050.70769030
74* GnRH signaling pathway_Homo sapiens_hsa049120.70675430
75Alcoholism_Homo sapiens_hsa050340.70559265
76RNA transport_Homo sapiens_hsa030130.69680500
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67307222
78Non-small cell lung cancer_Homo sapiens_hsa052230.66298635
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64128356
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63334793
81* FoxO signaling pathway_Homo sapiens_hsa040680.63097612
82mTOR signaling pathway_Homo sapiens_hsa041500.62399072
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61001560
84Bile secretion_Homo sapiens_hsa049760.59690320
85Cell cycle_Homo sapiens_hsa041100.58837902
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58660240
87Melanogenesis_Homo sapiens_hsa049160.58370028
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58110927
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57119421
90Mismatch repair_Homo sapiens_hsa034300.56210709
91Long-term depression_Homo sapiens_hsa047300.56069852
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54712434
93* VEGF signaling pathway_Homo sapiens_hsa043700.52336570
94* Leukocyte transendothelial migration_Homo sapiens_hsa046700.51237072
95* MAPK signaling pathway_Homo sapiens_hsa040100.50956755
96* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50761482
97* Neurotrophin signaling pathway_Homo sapiens_hsa047220.50626121
98PPAR signaling pathway_Homo sapiens_hsa033200.48832061
99Spliceosome_Homo sapiens_hsa030400.48631616
100Thyroid cancer_Homo sapiens_hsa052160.48372841
101Gap junction_Homo sapiens_hsa045400.48288304
102Type II diabetes mellitus_Homo sapiens_hsa049300.47750355
103Selenocompound metabolism_Homo sapiens_hsa004500.47489067
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.47451935
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45232136
106ErbB signaling pathway_Homo sapiens_hsa040120.45184379
107Insulin secretion_Homo sapiens_hsa049110.44937287
108Phenylalanine metabolism_Homo sapiens_hsa003600.44345731
109Circadian entrainment_Homo sapiens_hsa047130.43929375
110Renin secretion_Homo sapiens_hsa049240.43666014
111Lysine degradation_Homo sapiens_hsa003100.42588948
112ECM-receptor interaction_Homo sapiens_hsa045120.41975351
113beta-Alanine metabolism_Homo sapiens_hsa004100.41921003
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.41890096
115* Platelet activation_Homo sapiens_hsa046110.41756170
116Long-term potentiation_Homo sapiens_hsa047200.38974821
117Folate biosynthesis_Homo sapiens_hsa007900.37113892
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35774302
119Small cell lung cancer_Homo sapiens_hsa052220.35694285
120Cholinergic synapse_Homo sapiens_hsa047250.35596215
121* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35043297
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34442758
123* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33712030
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32902960
125Dorso-ventral axis formation_Homo sapiens_hsa043200.32441759
126Butanoate metabolism_Homo sapiens_hsa006500.31987124
127Tyrosine metabolism_Homo sapiens_hsa003500.30952529
128Notch signaling pathway_Homo sapiens_hsa043300.30652965
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30013296
130Bladder cancer_Homo sapiens_hsa052190.29901871
131* Oocyte meiosis_Homo sapiens_hsa041140.29886956
132TGF-beta signaling pathway_Homo sapiens_hsa043500.29292772
133* Rap1 signaling pathway_Homo sapiens_hsa040150.28959117
134Fatty acid biosynthesis_Homo sapiens_hsa000610.27746849
135Pentose phosphate pathway_Homo sapiens_hsa000300.27741445
136Chronic myeloid leukemia_Homo sapiens_hsa052200.25870156
137Amoebiasis_Homo sapiens_hsa051460.25614687
138* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25052941

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »