MAPK11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61322743
2synaptic vesicle exocytosis (GO:0016079)5.34551641
3glutamate secretion (GO:0014047)5.17327432
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.06754075
5cell migration in hindbrain (GO:0021535)4.99624124
6regulation of synaptic vesicle exocytosis (GO:2000300)4.88004539
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86029989
8synaptic vesicle maturation (GO:0016188)4.84753596
9vocalization behavior (GO:0071625)4.76353064
10negative regulation of microtubule polymerization (GO:0031115)4.74137204
11neuron cell-cell adhesion (GO:0007158)4.67284390
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.47221628
13negative regulation of dendrite morphogenesis (GO:0050774)4.34402603
14protein localization to synapse (GO:0035418)4.33554090
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30033154
16locomotory exploration behavior (GO:0035641)4.28894582
17regulation of glutamate receptor signaling pathway (GO:1900449)4.28317240
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.27836510
19regulation of synaptic vesicle transport (GO:1902803)4.23854468
20sodium ion export (GO:0071436)4.17871791
21neuronal ion channel clustering (GO:0045161)4.17726941
22layer formation in cerebral cortex (GO:0021819)4.11354289
23regulation of synapse structural plasticity (GO:0051823)4.06575936
24negative regulation of dendrite development (GO:2000171)4.03151875
25cerebellar granule cell differentiation (GO:0021707)4.02757686
26neuronal action potential propagation (GO:0019227)3.96069767
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.90946386
28regulation of ARF protein signal transduction (GO:0032012)3.88204156
29neurotransmitter secretion (GO:0007269)3.87672027
30cerebellar Purkinje cell differentiation (GO:0021702)3.81237464
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.71812658
32membrane depolarization during action potential (GO:0086010)3.67688998
33synaptic vesicle endocytosis (GO:0048488)3.66603179
34axonal fasciculation (GO:0007413)3.65514259
35proline transport (GO:0015824)3.63561691
36neuron recognition (GO:0008038)3.61010622
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61007867
38regulation of neuronal synaptic plasticity (GO:0048168)3.57369666
39neuromuscular process controlling balance (GO:0050885)3.56949356
40exploration behavior (GO:0035640)3.53443614
41positive regulation of synapse maturation (GO:0090129)3.50253766
42detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.43878498
43detection of temperature stimulus involved in sensory perception (GO:0050961)3.43878498
44dendritic spine organization (GO:0097061)3.41000750
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40611564
46response to pheromone (GO:0019236)3.35801443
47positive regulation of neurotransmitter secretion (GO:0001956)3.32808216
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.32615135
49regulation of neurotransmitter secretion (GO:0046928)3.30406863
50positive regulation of dendritic spine development (GO:0060999)3.29579492
51semaphorin-plexin signaling pathway (GO:0071526)3.26316473
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25412831
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25036800
54pyrimidine nucleobase catabolic process (GO:0006208)3.23607538
55synaptic transmission, glutamatergic (GO:0035249)3.23309783
56amino acid import (GO:0043090)3.22759463
57L-amino acid import (GO:0043092)3.20119526
58detection of temperature stimulus (GO:0016048)3.14440721
59neuromuscular synaptic transmission (GO:0007274)3.14030310
60dendritic spine morphogenesis (GO:0060997)3.13834902
61regulation of NFAT protein import into nucleus (GO:0051532)3.13329919
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12452836
63postsynaptic membrane organization (GO:0001941)3.10150798
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09985847
65dendrite morphogenesis (GO:0048813)3.09301883
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08922215
67membrane depolarization (GO:0051899)3.07720967
68neuron-neuron synaptic transmission (GO:0007270)3.06171751
69regulation of postsynaptic membrane potential (GO:0060078)3.04768165
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04520128
71establishment of nucleus localization (GO:0040023)3.03140220
72innervation (GO:0060384)3.01302510
73regulation of synaptic plasticity (GO:0048167)3.00643934
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00335444
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00207569
76glutamate receptor signaling pathway (GO:0007215)2.98697955
77neuronal action potential (GO:0019228)2.98221558
78establishment of mitochondrion localization (GO:0051654)2.98161673
79neurotransmitter transport (GO:0006836)2.97721305
80axon ensheathment in central nervous system (GO:0032291)2.97647493
81central nervous system myelination (GO:0022010)2.97647493
82synapse assembly (GO:0007416)2.96362698
83regulation of neurotransmitter transport (GO:0051588)2.94518846
84central nervous system projection neuron axonogenesis (GO:0021952)2.93474907
85activation of protein kinase A activity (GO:0034199)2.92831073
86regulation of ARF GTPase activity (GO:0032312)2.91359993
87mitochondrion transport along microtubule (GO:0047497)2.88708996
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88708996
89intraspecies interaction between organisms (GO:0051703)2.87503275
90social behavior (GO:0035176)2.87503275
91cell communication by electrical coupling (GO:0010644)2.86418018
92neurofilament cytoskeleton organization (GO:0060052)2.85461070
93long-term synaptic potentiation (GO:0060291)2.84743868
94regulation of vesicle fusion (GO:0031338)2.84708326
95dopamine receptor signaling pathway (GO:0007212)2.84282998
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.84212208
97cellular potassium ion homeostasis (GO:0030007)2.83356667
98synaptic vesicle transport (GO:0048489)2.83161622
99establishment of synaptic vesicle localization (GO:0097480)2.83161622
100potassium ion homeostasis (GO:0055075)2.81512024
101mating behavior (GO:0007617)2.80569801
102positive regulation of synapse assembly (GO:0051965)2.79556323
103regulation of dendrite morphogenesis (GO:0048814)2.76656312
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75875646
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75648873
106regulation of neurotransmitter levels (GO:0001505)2.75582123
107regulation of respiratory system process (GO:0044065)2.75357689
108positive regulation of membrane potential (GO:0045838)2.74587784
109activation of MAPKKK activity (GO:0000185)2.74242063
110vesicle transport along microtubule (GO:0047496)2.73591126
111cerebellar Purkinje cell layer development (GO:0021680)2.73579834
112cAMP biosynthetic process (GO:0006171)2.73133544
113establishment of vesicle localization (GO:0051650)2.71364348
114axon extension (GO:0048675)2.70957794
115regulation of synapse assembly (GO:0051963)2.70898209
116regulation of synapse maturation (GO:0090128)2.70765854
117positive regulation of synaptic transmission (GO:0050806)2.70490685
118regulation of synaptic transmission (GO:0050804)2.70177375
119negative regulation of erythrocyte differentiation (GO:0045647)2.70088571
120regulation of synapse organization (GO:0050807)2.68342600
121neuromuscular process controlling posture (GO:0050884)2.68322371
122auditory behavior (GO:0031223)2.67527356
123protein localization to endosome (GO:0036010)2.67520633
124regulation of voltage-gated calcium channel activity (GO:1901385)2.67099698
125glycosphingolipid biosynthetic process (GO:0006688)2.66481080
126adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.65500477
127positive regulation of neurotransmitter transport (GO:0051590)2.65280688
128neurotransmitter-gated ion channel clustering (GO:0072578)2.64513525
129negative regulation of axonogenesis (GO:0050771)2.64231398
130negative regulation of amino acid transport (GO:0051956)2.64147357
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63918347
132positive regulation of dendrite development (GO:1900006)2.63803422
133positive regulation of protein dephosphorylation (GO:0035307)2.63221248
134peptidyl-tyrosine autophosphorylation (GO:0038083)2.61682932
135cell-cell junction maintenance (GO:0045217)2.55239282
136cellular response to catecholamine stimulus (GO:0071870)2.54843931
137cellular response to monoamine stimulus (GO:0071868)2.54843931
138protein targeting to plasma membrane (GO:0072661)2.51235091
139mannose metabolic process (GO:0006013)2.50247593
140positive regulation of Rap GTPase activity (GO:0032854)2.48809104
141protein retention in ER lumen (GO:0006621)2.47151183
142neuron projection extension (GO:1990138)2.46433253
143regulation of early endosome to late endosome transport (GO:2000641)2.42444421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.10821920
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.64780168
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10353179
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.09498637
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07520347
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88141433
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88141433
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86330414
9GBX2_23144817_ChIP-Seq_PC3_Human2.84140561
10REST_21632747_ChIP-Seq_MESCs_Mouse2.81799287
11LXR_22292898_ChIP-Seq_THP-1_Human2.72724563
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68337830
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67731382
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63587447
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62259500
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.56801128
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48765479
18* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47245540
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44689704
20DROSHA_22980978_ChIP-Seq_HELA_Human2.43598859
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.40899798
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.40583911
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40280121
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.37874317
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.34247013
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34215937
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33080305
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32194797
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31283926
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.25883407
31* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25604602
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18619383
33TAF15_26573619_Chip-Seq_HEK293_Human1.96782541
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88464014
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.87571245
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.87488207
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85574096
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79204695
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78565383
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76083512
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.74129493
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70584010
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66586537
44AR_21572438_ChIP-Seq_LNCaP_Human1.66027206
45RACK7_27058665_Chip-Seq_MCF-7_Human1.61958662
46P68_20966046_ChIP-Seq_HELA_Human1.60177197
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59499525
48SMC4_20622854_ChIP-Seq_HELA_Human1.58143395
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.58128728
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.55644472
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54582914
52* TET1_21451524_ChIP-Seq_MESCs_Mouse1.53707368
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.48867601
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47840950
55RNF2_27304074_Chip-Seq_NSC_Mouse1.45146346
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41500558
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41456152
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41190008
59IGF1R_20145208_ChIP-Seq_DFB_Human1.38924027
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.38865001
61KDM2B_26808549_Chip-Seq_K562_Human1.38105767
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36937522
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35113668
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34459886
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33687499
66* VDR_21846776_ChIP-Seq_THP-1_Human1.33413162
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32983042
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32138175
69ZNF274_21170338_ChIP-Seq_K562_Hela1.32081028
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32016813
71* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31866968
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31534639
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.31000549
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29978406
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29746181
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.29189472
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29173262
78* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29017635
79SMAD4_21799915_ChIP-Seq_A2780_Human1.28690221
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.27215148
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26998154
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26890193
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23530889
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23199785
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.23199451
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22704518
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21724938
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19505058
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18834350
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.18523222
91* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17544876
92* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17453113
93P300_19829295_ChIP-Seq_ESCs_Human1.14900111
94* AR_19668381_ChIP-Seq_PC3_Human1.13844189
95* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13819248
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12800141
97AR_25329375_ChIP-Seq_VCAP_Human1.12748751
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11599623
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09757194
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08554177
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08449892
102TP53_22127205_ChIP-Seq_IMR90_Human1.08442783
103TP53_23651856_ChIP-Seq_MEFs_Mouse1.06929076
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.06836176
105CLOCK_20551151_ChIP-Seq_293T_Human1.06206810
106* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05896563
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03684909
108OCT4_19829295_ChIP-Seq_ESCs_Human1.02079354
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.01903384
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01445405
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01044778
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00993777
113SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00159123
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99841495
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99695353
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.98485008
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97819046
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96370950
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95923235
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95906410
121AHR_22903824_ChIP-Seq_MCF-7_Human0.95090736
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93713839
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93713839
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93584852
125TP63_22573176_ChIP-Seq_HFKS_Human0.93016637
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92710231
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92631570
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92559726
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.92185734
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91956682
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91694735
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.90729883
133STAT3_23295773_ChIP-Seq_U87_Human0.90038611
134* KDM2B_26808549_Chip-Seq_DND41_Human0.89853418
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.89260543
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.86361326
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85411642
138* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83937254
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82165179
140* KDM2B_26808549_Chip-Seq_JURKAT_Human0.80696150
141* CTCF_27219007_Chip-Seq_Bcells_Human0.80314503
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79975343
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.79803840
144JUN_21703547_ChIP-Seq_K562_Human0.77975059
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76920976
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76613077
147POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.75990392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22015840
2MP0001968_abnormal_touch/_nociception4.33192520
3MP0003880_abnormal_central_pattern4.15046945
4MP0004270_analgesia3.85589240
5MP0002735_abnormal_chemical_nociception3.75049361
6MP0006276_abnormal_autonomic_nervous3.61250034
7MP0002736_abnormal_nociception_after3.58295071
8MP0003635_abnormal_synaptic_transmissio3.45833715
9MP0002734_abnormal_mechanical_nocicepti3.11820044
10MP0003705_abnormal_hypodermis_morpholog2.99875360
11MP0002063_abnormal_learning/memory/cond2.88216466
12MP0004858_abnormal_nervous_system2.81270225
13MP0002733_abnormal_thermal_nociception2.74119072
14MP0005423_abnormal_somatic_nervous2.71838091
15MP0009745_abnormal_behavioral_response2.70131775
16MP0002184_abnormal_innervation2.57410387
17MP0002064_seizures2.51716378
18MP0001970_abnormal_pain_threshold2.41417210
19MP0002572_abnormal_emotion/affect_behav2.34952885
20MP0002272_abnormal_nervous_system2.22732382
21MP0000778_abnormal_nervous_system2.21120234
22MP0009046_muscle_twitch2.15679029
23MP0001984_abnormal_olfaction2.13858663
24MP0002067_abnormal_sensory_capabilities2.09443172
25MP0003122_maternal_imprinting2.00694300
26MP0004811_abnormal_neuron_physiology1.98124005
27MP0005499_abnormal_olfactory_system1.95592599
28MP0005394_taste/olfaction_phenotype1.95592599
29MP0001501_abnormal_sleep_pattern1.93807091
30MP0003690_abnormal_glial_cell1.88909244
31MP0001440_abnormal_grooming_behavior1.84756711
32MP0001486_abnormal_startle_reflex1.82085532
33MP0004130_abnormal_muscle_cell1.76031160
34MP0002557_abnormal_social/conspecific_i1.74281501
35MP0003279_aneurysm1.68152965
36MP0003123_paternal_imprinting1.64486028
37MP0005666_abnormal_adipose_tissue1.63078540
38MP0008569_lethality_at_weaning1.58964972
39MP0003172_abnormal_lysosome_physiology1.57739951
40MP0000955_abnormal_spinal_cord1.56514294
41MP0005167_abnormal_blood-brain_barrier1.54571822
42MP0003787_abnormal_imprinting1.54331232
43MP0010368_abnormal_lymphatic_system1.53378628
44MP0005409_darkened_coat_color1.53022665
45MP0005645_abnormal_hypothalamus_physiol1.51821081
46MP0008789_abnormal_olfactory_epithelium1.50962979
47MP0002751_abnormal_autonomic_nervous1.50782929
48MP0005058_abnormal_lysosome_morphology1.46201308
49MP0003634_abnormal_glial_cell1.45907605
50MP0000920_abnormal_myelination1.45585802
51MP0002822_catalepsy1.45152103
52MP0005623_abnormal_meninges_morphology1.44879048
53MP0005670_abnormal_white_adipose1.43311536
54MP0005386_behavior/neurological_phenoty1.42344243
55MP0004924_abnormal_behavior1.42344243
56MP0005375_adipose_tissue_phenotype1.41957783
57MP0000003_abnormal_adipose_tissue1.41206296
58MP0002653_abnormal_ependyma_morphology1.41128792
59MP0003879_abnormal_hair_cell1.40917930
60MP0002882_abnormal_neuron_morphology1.40879400
61MP0000569_abnormal_digit_pigmentation1.40150373
62MP0004185_abnormal_adipocyte_glucose1.38870993
63MP0008438_abnormal_cutaneous_collagen1.38125346
64MP0001958_emphysema1.32614212
65MP0001849_ear_inflammation1.30030483
66MP0001905_abnormal_dopamine_level1.29303507
67MP0001986_abnormal_taste_sensitivity1.27728107
68MP0002066_abnormal_motor_capabilities/c1.22743169
69MP0004742_abnormal_vestibular_system1.19297519
70MP0002152_abnormal_brain_morphology1.14676547
71MP0000604_amyloidosis1.13001218
72MP0000013_abnormal_adipose_tissue1.12730573
73MP0005535_abnormal_body_temperature1.11910214
74MP0003075_altered_response_to1.07261091
75MP0003329_amyloid_beta_deposits1.05409484
76MP0001529_abnormal_vocalization1.05299877
77MP0010386_abnormal_urinary_bladder1.02578883
78MP0002909_abnormal_adrenal_gland1.01560538
79MP0003633_abnormal_nervous_system1.01237219
80MP0004145_abnormal_muscle_electrophysio1.00666368
81MP0008872_abnormal_physiological_respon0.97142842
82MP0003121_genomic_imprinting0.96468668
83MP0008260_abnormal_autophagy0.95503719
84MP0008961_abnormal_basal_metabolism0.95479783
85MP0002089_abnormal_postnatal_growth/wei0.93503809
86MP0003861_abnormal_nervous_system0.92049456
87MP0002752_abnormal_somatic_nervous0.91339264
88MP0001502_abnormal_circadian_rhythm0.90668488
89MP0002249_abnormal_larynx_morphology0.90566691
90MP0008874_decreased_physiological_sensi0.90181399
91MP0005646_abnormal_pituitary_gland0.89843365
92MP0002971_abnormal_brown_adipose0.86516603
93MP0003566_abnormal_cell_adhesion0.86140348
94MP0003631_nervous_system_phenotype0.85963931
95MP0002638_abnormal_pupillary_reflex0.85824425
96MP0003303_peritoneal_inflammation0.84733764
97MP0009384_cardiac_valve_regurgitation0.83175958
98MP0005595_abnormal_vascular_smooth0.82559513
99MP0001188_hyperpigmentation0.81206637
100MP0000751_myopathy0.81183149
101MP0002069_abnormal_eating/drinking_beha0.81042870
102MP0003183_abnormal_peptide_metabolism0.79843262
103MP0006138_congestive_heart_failure0.78639771
104MP0001879_abnormal_lymphatic_vessel0.77748418
105MP0002295_abnormal_pulmonary_circulatio0.76930644
106MP0000767_abnormal_smooth_muscle0.76847440
107MP0003890_abnormal_embryonic-extraembry0.75607623
108MP0003948_abnormal_gas_homeostasis0.73368731
109MP0009780_abnormal_chondrocyte_physiolo0.73140360
110MP0001963_abnormal_hearing_physiology0.72663463
111MP0000759_abnormal_skeletal_muscle0.71388126
112MP0000538_abnormal_urinary_bladder0.71331002
113MP0006292_abnormal_olfactory_placode0.71319572
114MP0004142_abnormal_muscle_tone0.71224737
115MP0000631_abnormal_neuroendocrine_gland0.70767120
116MP0000747_muscle_weakness0.70395361
117MP0004885_abnormal_endolymph0.69002450
118MP0001299_abnormal_eye_distance/0.68680658
119MP0010030_abnormal_orbit_morphology0.68127822
120MP0005503_abnormal_tendon_morphology0.66613446
121MP0000733_abnormal_muscle_development0.64453503
122MP0000534_abnormal_ureter_morphology0.64249417
123MP0004272_abnormal_basement_membrane0.64047826
124MP0001943_abnormal_respiration0.64025039
125MP0009379_abnormal_foot_pigmentation0.63183058
126MP0003632_abnormal_nervous_system0.62591093
127MP0010769_abnormal_survival0.62515168
128MP0004085_abnormal_heartbeat0.62452206
129MP0002082_postnatal_lethality0.62097695
130MP0010770_preweaning_lethality0.62097695
131MP0001664_abnormal_digestion0.60750482
132MP0005257_abnormal_intraocular_pressure0.59510256
133MP0010768_mortality/aging0.58829220
134MP0002234_abnormal_pharynx_morphology0.57588061
135MP0002229_neurodegeneration0.57571922
136MP0002160_abnormal_reproductive_system0.55001854
137MP0000015_abnormal_ear_pigmentation0.54039992
138MP0003938_abnormal_ear_development0.52000645
139MP0002081_perinatal_lethality0.51904550
140MP0001177_atelectasis0.51901420
141MP0004510_myositis0.49186215
142MP0000026_abnormal_inner_ear0.48654848
143MP0002102_abnormal_ear_morphology0.47942702
144MP0001348_abnormal_lacrimal_gland0.47835671
145MP0003942_abnormal_urinary_system0.47224511
146MP0003091_abnormal_cell_migration0.45882929

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.08282352
2Myokymia (HP:0002411)5.66390931
3Focal seizures (HP:0007359)5.16715448
4Obstructive sleep apnea (HP:0002870)4.49201145
5Febrile seizures (HP:0002373)4.29185550
6Atonic seizures (HP:0010819)4.16717799
7Epileptic encephalopathy (HP:0200134)3.90211397
8Neurofibrillary tangles (HP:0002185)3.87055292
9Progressive cerebellar ataxia (HP:0002073)3.71293293
10Amblyopia (HP:0000646)3.56851393
11Failure to thrive in infancy (HP:0001531)3.51351061
12Cerebral inclusion bodies (HP:0100314)3.49527252
13Visual hallucinations (HP:0002367)3.47777599
14Absence seizures (HP:0002121)3.30624225
15Protrusio acetabuli (HP:0003179)3.30473899
16Limb dystonia (HP:0002451)3.26512427
17Broad-based gait (HP:0002136)3.22712332
18Upper limb amyotrophy (HP:0009129)3.18980240
19Distal upper limb amyotrophy (HP:0007149)3.18980240
20Cerebral aneurysm (HP:0004944)3.16729240
21Action tremor (HP:0002345)3.03243706
22Urinary urgency (HP:0000012)3.02699059
23Poor eye contact (HP:0000817)3.02194443
24Impaired vibration sensation in the lower limbs (HP:0002166)3.00555705
25Supranuclear gaze palsy (HP:0000605)2.99816145
26Ankle clonus (HP:0011448)2.98231362
27Ulnar claw (HP:0001178)2.97932020
28Dialeptic seizures (HP:0011146)2.94620501
29Abnormality of the lower motor neuron (HP:0002366)2.93942107
30Abnormality of binocular vision (HP:0011514)2.91355401
31Diplopia (HP:0000651)2.91355401
32Exotropia (HP:0000577)2.85795876
33Abnormal eating behavior (HP:0100738)2.80712644
34Shallow orbits (HP:0000586)2.79985247
35Impaired social interactions (HP:0000735)2.75824321
36Abnormal social behavior (HP:0012433)2.75824321
37Pheochromocytoma (HP:0002666)2.75441815
38Hypoplasia of the brainstem (HP:0002365)2.75251074
39Aplasia/Hypoplasia of the brainstem (HP:0007362)2.75251074
40Hand muscle atrophy (HP:0009130)2.73057492
41Truncal ataxia (HP:0002078)2.70371540
42Hypoventilation (HP:0002791)2.69685705
43Polyphagia (HP:0002591)2.66286354
44Impaired pain sensation (HP:0007328)2.64158438
45Abnormality of pain sensation (HP:0010832)2.64158438
46Insidious onset (HP:0003587)2.64140790
47Termporal pattern (HP:0011008)2.64140790
48Turricephaly (HP:0000262)2.62398703
49Lower limb amyotrophy (HP:0007210)2.55255043
50Premature rupture of membranes (HP:0001788)2.55155565
51Nuclear cataract (HP:0100018)2.54685126
52Generalized tonic-clonic seizures (HP:0002069)2.49880440
53Neuronal loss in central nervous system (HP:0002529)2.47154329
54Spinal canal stenosis (HP:0003416)2.45436954
55Broad face (HP:0000283)2.45325196
56Neuroendocrine neoplasm (HP:0100634)2.44583828
57Hyperacusis (HP:0010780)2.41871975
58Shoulder girdle muscle weakness (HP:0003547)2.40238980
59Pointed chin (HP:0000307)2.40231877
60Spastic gait (HP:0002064)2.37821368
61Hyperventilation (HP:0002883)2.36839202
62Mitral regurgitation (HP:0001653)2.34089843
63Stridor (HP:0010307)2.31241239
64Urinary bladder sphincter dysfunction (HP:0002839)2.30770108
65Insomnia (HP:0100785)2.27214973
66Cervical subluxation (HP:0003308)2.26995738
67Aqueductal stenosis (HP:0002410)2.26689059
68Apathy (HP:0000741)2.26395942
69Depression (HP:0000716)2.26002302
70Thin bony cortex (HP:0002753)2.25174603
71Broad metatarsal (HP:0001783)2.24147930
72Distal lower limb amyotrophy (HP:0008944)2.23843854
73Abnormal hair whorl (HP:0010721)2.23372792
74Generalized hypotonia (HP:0001290)2.19706244
75Peripheral hypomyelination (HP:0007182)2.15044521
76Drooling (HP:0002307)2.14761905
77Excessive salivation (HP:0003781)2.14761905
78Bladder diverticulum (HP:0000015)2.12953684
79Stereotypic behavior (HP:0000733)2.12437190
80Increased variability in muscle fiber diameter (HP:0003557)2.11986367
81Dysmetria (HP:0001310)2.11641413
82Annular pancreas (HP:0001734)2.09640892
83Craniofacial dystonia (HP:0012179)2.09010913
84Fetal akinesia sequence (HP:0001989)2.08867048
85J-shaped sella turcica (HP:0002680)2.07805958
86Difficulty climbing stairs (HP:0003551)2.06721721
87Diminished motivation (HP:0000745)2.06266400
88Lissencephaly (HP:0001339)2.06182845
89Tetraplegia (HP:0002445)2.05193547
90Wrist flexion contracture (HP:0001239)2.05091155
91Rapidly progressive (HP:0003678)2.04943995
92Bronchomalacia (HP:0002780)2.03414690
93Hypothermia (HP:0002045)2.03113701
94Specific learning disability (HP:0001328)2.01074973
95Hypercortisolism (HP:0001578)2.00519222
96Hyperthyroidism (HP:0000836)1.99550073
97Impaired smooth pursuit (HP:0007772)1.99496723
98Scanning speech (HP:0002168)1.99310574
99Spinal rigidity (HP:0003306)1.99208940
100Overgrowth (HP:0001548)1.97824577
101Hammertoe (HP:0001765)1.97745811
102Neoplasm of the heart (HP:0100544)1.97563537
103Progressive inability to walk (HP:0002505)1.97476620
104Clonus (HP:0002169)1.97375099
105Hyperparathyroidism (HP:0000843)1.96726990
106Esotropia (HP:0000565)1.96242603
107Epileptiform EEG discharges (HP:0011182)1.96149248
108Abnormality of the labia minora (HP:0012880)1.95606557
109Lymphangioma (HP:0100764)1.95519439
110Achilles tendon contracture (HP:0001771)1.95090648
111Bowel diverticulosis (HP:0005222)1.94999514
112Incomplete penetrance (HP:0003829)1.94470211
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94454968
114Intention tremor (HP:0002080)1.94309244
115Papilledema (HP:0001085)1.93694533
116Pelvic girdle muscle weakness (HP:0003749)1.93337251
117Hemiplegia (HP:0002301)1.93093938
118Postural instability (HP:0002172)1.91594439
119Absent speech (HP:0001344)1.90712651
120Lower limb muscle weakness (HP:0007340)1.89931107
121Narrow nasal bridge (HP:0000446)1.88800362
122Gaze-evoked nystagmus (HP:0000640)1.88185882
123Axonal loss (HP:0003447)1.87988414
124Agitation (HP:0000713)1.87551081
125Abnormality of the musculature of the pelvis (HP:0001469)1.86759301
126Abnormality of the hip-girdle musculature (HP:0001445)1.86759301
127EEG with generalized epileptiform discharges (HP:0011198)1.86342104
128Arterial tortuosity (HP:0005116)1.85099723
129Foot dorsiflexor weakness (HP:0009027)1.84839996
130Autism (HP:0000717)1.83842428
131Mutism (HP:0002300)1.83605012
132Torticollis (HP:0000473)1.82735227
133Genetic anticipation (HP:0003743)1.81600368
134Truncus arteriosus (HP:0001660)1.81175630
135Vascular tortuosity (HP:0004948)1.80253404
136Distal sensory impairment (HP:0002936)1.80111399
137Protruding tongue (HP:0010808)1.80093285
138Overriding aorta (HP:0002623)1.78783590
139Dysostosis multiplex (HP:0000943)1.78141426
140Ventricular fibrillation (HP:0001663)1.78108570
141Lower limb asymmetry (HP:0100559)1.76801027
142Open mouth (HP:0000194)1.75803425
143Hypsarrhythmia (HP:0002521)1.74951166
144Myotonia (HP:0002486)1.74620277
145Atrophic scars (HP:0001075)1.74548000
146Sleep apnea (HP:0010535)1.73968645
147Elfin facies (HP:0004428)1.73708244
148Growth hormone excess (HP:0000845)1.71267101
149Aplasia involving bones of the extremities (HP:0009825)1.71110650
150Aplasia involving bones of the upper limbs (HP:0009823)1.71110650
151Aplasia of the phalanges of the hand (HP:0009802)1.71110650
152Deep palmar crease (HP:0006191)1.70541916
153Abnormality of the corticospinal tract (HP:0002492)1.70379879
154Fragile skin (HP:0001030)1.70176044
155Anxiety (HP:0000739)1.69578623
156Sacral dimple (HP:0000960)1.69211233
157Amyotrophic lateral sclerosis (HP:0007354)1.68596271
158Focal dystonia (HP:0004373)1.68453457
159Increased connective tissue (HP:0009025)1.68404630
160Abnormal atrioventricular conduction (HP:0005150)1.67659718
161Ulnar bowing (HP:0003031)1.67504224
162Rigidity (HP:0002063)1.67044160
163Megalencephaly (HP:0001355)1.66739149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK33.90227140
2MAP3K43.56704654
3NTRK33.52121377
4TRIB33.52018538
5MAP3K93.09200167
6MINK13.05915050
7MAP2K72.83697541
8MARK12.68103865
9MAP3K122.61077620
10CASK2.43479096
11MAP2K42.38637365
12SIK22.29610204
13DAPK22.28685261
14PAK62.11158110
15NTRK22.08594373
16KSR12.00784104
17EPHA41.94110454
18NTRK11.87796597
19UHMK11.87452725
20CDK191.87323520
21DAPK11.85084573
22ICK1.82802254
23MAPK131.71486957
24SIK11.68595569
25PDGFRA1.62145914
26RIPK41.57397342
27CAMKK11.41404155
28TIE11.38994999
29CDK51.37313180
30CCNB11.34627882
31TESK11.34245197
32CAMKK21.32184338
33PLK21.26214802
34GRK51.25886835
35RET1.24664776
36KSR21.22412795
37MAPK121.16429630
38PTK21.14503739
39TYRO31.13081389
40SGK4941.09920638
41SGK2231.09920638
42LATS21.02387003
43PRPF4B1.01794484
44MAPKAPK31.01026700
45PRKCG1.00463102
46TAOK11.00417920
47CDK180.99875567
48MAP3K60.98505805
49MAP2K30.98391752
50SGK20.91898466
51FGFR20.91572724
52ARAF0.91006881
53PDPK10.87506583
54PRKCH0.85966453
55BRAF0.85502138
56MARK20.84490179
57DDR20.84310959
58CDK150.83916614
59PRKD20.82597204
60LIMK10.81906634
61PRKD30.81871305
62CDK140.80974420
63TTN0.79404481
64MAPK150.77455743
65PAK30.75903946
66PKN20.75679368
67BCR0.75573001
68FGFR30.75527474
69SMG10.75363127
70CDK11A0.73680071
71MAP3K130.72526219
72RPS6KA20.72293810
73MAP4K10.72244304
74ERN10.71476687
75CAMK1G0.71331594
76DAPK30.70721902
77BRSK10.70664797
78EPHB20.69200263
79MOS0.68746595
80LMTK20.68075543
81SGK30.67804075
82IRAK30.67163054
83CSNK1G20.66537146
84ERBB30.66534089
85CAMK10.66525525
86MAP2K10.65888688
87FER0.65555630
88GRK60.65471796
89DYRK20.65326115
90SCYL20.62214692
91DYRK1A0.61473412
92MAPK100.59973839
93CAMK2G0.59205479
94CAMK1D0.57767846
95CAMK40.57401790
96ADRBK10.57307438
97PNCK0.57282345
98FES0.55944670
99EPHB10.55359073
100ADRBK20.54776685
101SYK0.54179539
102MTOR0.53326099
103MAP3K110.52799948
104PHKG10.52378821
105PHKG20.52378821
106FGFR10.52217813
107CAMK2A0.52062954
108PDGFRB0.51716831
109MAP2K60.51192922
110MAPK40.50316114
111PAK20.49945819
112STK110.48039907
113PKN10.48019457
114TAOK20.47402077
115ROCK10.46315371
116PTK2B0.46123534
117MATK0.43612118
118BMX0.43603603
119PRKG20.43348287
120IRAK20.43201112
121CDC42BPA0.43127561
122FGFR40.42998418
123ALK0.42721246
124NEK60.42660847
125STK380.42328209
126MET0.41977764
127ROCK20.41058650
128DMPK0.39287820
129MAP3K70.39137673
130CAMK2B0.37181534
131CSNK1G30.35658646
132TSSK60.35261490
133EEF2K0.35248650
134PDK10.35025895
135RIPK10.35018134
136TNK20.34100555
137MAP3K10.33441650
138FYN0.32872153

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.45905023
2Nicotine addiction_Homo sapiens_hsa050333.00364543
3Olfactory transduction_Homo sapiens_hsa047402.44871667
4Long-term potentiation_Homo sapiens_hsa047202.17091274
5Circadian entrainment_Homo sapiens_hsa047132.13195796
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.10954987
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09228552
8* Dopaminergic synapse_Homo sapiens_hsa047282.03966970
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01554600
10Glutamatergic synapse_Homo sapiens_hsa047241.94609090
11Morphine addiction_Homo sapiens_hsa050321.90620623
12Amphetamine addiction_Homo sapiens_hsa050311.84386868
13Cholinergic synapse_Homo sapiens_hsa047251.78129910
14GABAergic synapse_Homo sapiens_hsa047271.75442078
15Insulin secretion_Homo sapiens_hsa049111.68901044
16Salivary secretion_Homo sapiens_hsa049701.66404210
17Taste transduction_Homo sapiens_hsa047421.63142305
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.62815256
19* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.56160181
20Gastric acid secretion_Homo sapiens_hsa049711.56068570
21Collecting duct acid secretion_Homo sapiens_hsa049661.55508885
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49995592
23Axon guidance_Homo sapiens_hsa043601.49225742
24* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47870730
25Oxytocin signaling pathway_Homo sapiens_hsa049211.46601027
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44593397
27Long-term depression_Homo sapiens_hsa047301.42519041
28Gap junction_Homo sapiens_hsa045401.38513191
29* GnRH signaling pathway_Homo sapiens_hsa049121.37640145
30Serotonergic synapse_Homo sapiens_hsa047261.36893323
31ErbB signaling pathway_Homo sapiens_hsa040121.35915049
32Prion diseases_Homo sapiens_hsa050201.34190743
33* Neurotrophin signaling pathway_Homo sapiens_hsa047221.29887089
34Cocaine addiction_Homo sapiens_hsa050301.29392107
35Renin secretion_Homo sapiens_hsa049241.29247286
36Glioma_Homo sapiens_hsa052141.23959663
37Calcium signaling pathway_Homo sapiens_hsa040201.23039562
38Notch signaling pathway_Homo sapiens_hsa043301.21695851
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15250140
40Oocyte meiosis_Homo sapiens_hsa041141.14449247
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.14331580
42Estrogen signaling pathway_Homo sapiens_hsa049151.12678788
43* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11536610
44Melanogenesis_Homo sapiens_hsa049161.07828748
45Vitamin B6 metabolism_Homo sapiens_hsa007501.06592322
46* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06149589
47Colorectal cancer_Homo sapiens_hsa052101.04606137
48Vibrio cholerae infection_Homo sapiens_hsa051101.02825353
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02295020
50* T cell receptor signaling pathway_Homo sapiens_hsa046601.00529919
51Endometrial cancer_Homo sapiens_hsa052130.99620783
52* MAPK signaling pathway_Homo sapiens_hsa040100.98532097
53Type II diabetes mellitus_Homo sapiens_hsa049300.95352722
54* VEGF signaling pathway_Homo sapiens_hsa043700.94298983
55Other glycan degradation_Homo sapiens_hsa005110.94228363
56cAMP signaling pathway_Homo sapiens_hsa040240.92046153
57Focal adhesion_Homo sapiens_hsa045100.90709759
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87505310
59* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87063051
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83232917
61Dorso-ventral axis formation_Homo sapiens_hsa043200.82940106
62AMPK signaling pathway_Homo sapiens_hsa041520.81787115
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81040168
64Choline metabolism in cancer_Homo sapiens_hsa052310.78950521
65ECM-receptor interaction_Homo sapiens_hsa045120.78096163
66* Rap1 signaling pathway_Homo sapiens_hsa040150.77625292
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77354714
68mTOR signaling pathway_Homo sapiens_hsa041500.77285117
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.76924622
70B cell receptor signaling pathway_Homo sapiens_hsa046620.75010104
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74461173
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73992204
73Wnt signaling pathway_Homo sapiens_hsa043100.71850410
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71791561
75Endocytosis_Homo sapiens_hsa041440.70165999
76Non-small cell lung cancer_Homo sapiens_hsa052230.69876829
77Inositol phosphate metabolism_Homo sapiens_hsa005620.69770587
78* Prolactin signaling pathway_Homo sapiens_hsa049170.68344471
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67337776
80Ras signaling pathway_Homo sapiens_hsa040140.66376655
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66218947
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65357282
83* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65298070
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63548043
85Insulin signaling pathway_Homo sapiens_hsa049100.63183705
86Cardiac muscle contraction_Homo sapiens_hsa042600.61502550
87Renal cell carcinoma_Homo sapiens_hsa052110.61415837
88Bile secretion_Homo sapiens_hsa049760.60932047
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.60325158
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59924582
91Fatty acid biosynthesis_Homo sapiens_hsa000610.59442521
92Alcoholism_Homo sapiens_hsa050340.58930354
93Chemokine signaling pathway_Homo sapiens_hsa040620.58874934
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58731873
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58319051
96Amoebiasis_Homo sapiens_hsa051460.57862407
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56728732
98PPAR signaling pathway_Homo sapiens_hsa033200.56608823
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54500101
100Hedgehog signaling pathway_Homo sapiens_hsa043400.54171538
101* Proteoglycans in cancer_Homo sapiens_hsa052050.52866229
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.52302141
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52242194
104* Sphingolipid signaling pathway_Homo sapiens_hsa040710.51875554
105Phototransduction_Homo sapiens_hsa047440.51553340
106Thyroid hormone synthesis_Homo sapiens_hsa049180.50824426
107Acute myeloid leukemia_Homo sapiens_hsa052210.50744540
108Primary immunodeficiency_Homo sapiens_hsa053400.50690454
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49696707
110Dilated cardiomyopathy_Homo sapiens_hsa054140.49348159
111* Shigellosis_Homo sapiens_hsa051310.48686495
112* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48640533
113Hippo signaling pathway_Homo sapiens_hsa043900.48474716
114* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47871712
115Pancreatic cancer_Homo sapiens_hsa052120.47730820
116* Salmonella infection_Homo sapiens_hsa051320.46778820
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46761586
118HIF-1 signaling pathway_Homo sapiens_hsa040660.46067300
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46042773
120Chronic myeloid leukemia_Homo sapiens_hsa052200.45965903
121Phagosome_Homo sapiens_hsa041450.45950659
122Glucagon signaling pathway_Homo sapiens_hsa049220.45282365
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.44841590
124Bladder cancer_Homo sapiens_hsa052190.43024097
125Pancreatic secretion_Homo sapiens_hsa049720.42801451
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40341115

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