MAP4K3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.02813143
2regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.70393692
3embryonic retina morphogenesis in camera-type eye (GO:0060059)3.44782020
4embryonic foregut morphogenesis (GO:0048617)3.26644401
5positive regulation of dendritic spine morphogenesis (GO:0061003)3.25054055
6regulation of non-canonical Wnt signaling pathway (GO:2000050)3.22374224
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13885632
8regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.13594101
9axonal fasciculation (GO:0007413)3.08718229
10nuclear pore complex assembly (GO:0051292)3.08359861
11cellular potassium ion homeostasis (GO:0030007)3.05898651
12regulation of transforming growth factor beta2 production (GO:0032909)3.03345453
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.03025700
14axon extension involved in axon guidance (GO:0048846)3.03025700
15synaptic vesicle maturation (GO:0016188)3.01864414
16layer formation in cerebral cortex (GO:0021819)3.00527506
17locomotory exploration behavior (GO:0035641)2.96378816
18notochord development (GO:0030903)2.91639342
19dendrite morphogenesis (GO:0048813)2.85583924
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84992588
21vocalization behavior (GO:0071625)2.84186965
22protein localization to endosome (GO:0036010)2.84024364
23mitotic sister chromatid cohesion (GO:0007064)2.83802477
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83392032
25regulation of clathrin-mediated endocytosis (GO:2000369)2.82118926
26nuclear pore organization (GO:0006999)2.79277751
27axon extension (GO:0048675)2.76977636
28neuron recognition (GO:0008038)2.76112971
29cell adhesion mediated by integrin (GO:0033627)2.75908244
30sodium ion export (GO:0071436)2.75010713
31plasma membrane repair (GO:0001778)2.73797536
32pre-miRNA processing (GO:0031054)2.70922206
33dorsal/ventral axis specification (GO:0009950)2.70660146
34presynaptic membrane assembly (GO:0097105)2.70282292
35neuron remodeling (GO:0016322)2.69449616
36genitalia morphogenesis (GO:0035112)2.68405023
37establishment of nucleus localization (GO:0040023)2.63711072
38positive regulation of catenin import into nucleus (GO:0035413)2.60229967
39cell communication by electrical coupling (GO:0010644)2.58266795
40cytoskeletal anchoring at plasma membrane (GO:0007016)2.57926110
41hippo signaling (GO:0035329)2.57318226
42glutamate secretion (GO:0014047)2.57310046
43anterior/posterior axis specification, embryo (GO:0008595)2.54432208
44regulation of axon extension involved in axon guidance (GO:0048841)2.54387889
45insulin-like growth factor receptor signaling pathway (GO:0048009)2.50664176
46synaptic vesicle docking involved in exocytosis (GO:0016081)2.50182620
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48707277
48cardiac myofibril assembly (GO:0055003)2.48633570
49regulation of Rac protein signal transduction (GO:0035020)2.47616165
50cell migration involved in sprouting angiogenesis (GO:0002042)2.46346682
51positive regulation of synapse maturation (GO:0090129)2.44314966
52cellular sodium ion homeostasis (GO:0006883)2.43032839
53innervation (GO:0060384)2.42085344
54dendritic spine morphogenesis (GO:0060997)2.41839650
55regulation of centriole replication (GO:0046599)2.41516770
56neuron projection extension (GO:1990138)2.41053253
57synaptic vesicle exocytosis (GO:0016079)2.40265703
58exploration behavior (GO:0035640)2.40002834
59ionotropic glutamate receptor signaling pathway (GO:0035235)2.39791763
60chondrocyte proliferation (GO:0035988)2.39073302
61cell migration involved in gastrulation (GO:0042074)2.38425836
62cerebral cortex radially oriented cell migration (GO:0021799)2.37491797
63inner ear receptor cell development (GO:0060119)2.36589773
64vesicle transport along microtubule (GO:0047496)2.35773300
65positive regulation of fibroblast migration (GO:0010763)2.33791319
66negative regulation of cardiac muscle tissue development (GO:0055026)2.33562189
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32318622
68regulation of glutamate receptor signaling pathway (GO:1900449)2.31959158
69protein targeting to Golgi (GO:0000042)2.31697384
70regulation of axon guidance (GO:1902667)2.31383509
71regulation of dendritic spine morphogenesis (GO:0061001)2.30236535
72glutamate receptor signaling pathway (GO:0007215)2.29076578
73central nervous system projection neuron axonogenesis (GO:0021952)2.28374609
74cell communication involved in cardiac conduction (GO:0086065)2.27726963
75semaphorin-plexin signaling pathway (GO:0071526)2.27369024
76activation of protein kinase A activity (GO:0034199)2.27156611
77negative regulation of sodium ion transport (GO:0010766)2.27094480
78cerebral cortex cell migration (GO:0021795)2.26990529
79neurotransmitter-gated ion channel clustering (GO:0072578)2.25774298
80regulation of cardioblast differentiation (GO:0051890)2.23972730
81positive regulation of male gonad development (GO:2000020)2.22901491
82presynaptic membrane organization (GO:0097090)2.22792170
83regulation of synaptic vesicle exocytosis (GO:2000300)2.22209652
84regulation of synapse structural plasticity (GO:0051823)2.21495007
85regulation of establishment of cell polarity (GO:2000114)2.21367448
86metanephric mesenchyme development (GO:0072075)2.21327603
87regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.21238074
88morphogenesis of an epithelial sheet (GO:0002011)2.20770387
89regulation of long-term neuronal synaptic plasticity (GO:0048169)2.20726092
90bundle of His cell to Purkinje myocyte communication (GO:0086069)2.20408493
91positive regulation of SMAD protein import into nucleus (GO:0060391)2.19438078
92retina vasculature morphogenesis in camera-type eye (GO:0061299)2.18621764
93ephrin receptor signaling pathway (GO:0048013)2.18133333
94dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.18050940
95regulation of neuron migration (GO:2001222)2.17885251
96primitive streak formation (GO:0090009)2.17200311
97protein localization to synapse (GO:0035418)2.16850454
98proline transport (GO:0015824)2.16806503
99establishment of protein localization to Golgi (GO:0072600)2.16646300
100camera-type eye morphogenesis (GO:0048593)2.15349338
101negative regulation of keratinocyte proliferation (GO:0010839)2.15220699
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.15189899
103heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.14784046
104artery development (GO:0060840)2.14733536
105ectodermal placode formation (GO:0060788)2.14337685
106cell migration in hindbrain (GO:0021535)2.13367755
107nerve growth factor signaling pathway (GO:0038180)2.13323863
108establishment of apical/basal cell polarity (GO:0035089)2.13247432
109apical protein localization (GO:0045176)2.12909889
110negative regulation of activin receptor signaling pathway (GO:0032926)2.12421269
111macroautophagy (GO:0016236)2.12117924
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.12026936
113dendritic spine organization (GO:0097061)2.11184950
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.11090455
115hemidesmosome assembly (GO:0031581)2.07302081
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.06562661
117neuromuscular junction development (GO:0007528)2.06511898
118vascular endothelial growth factor signaling pathway (GO:0038084)2.06430522
119potassium ion import (GO:0010107)2.06408811
120glomerular visceral epithelial cell development (GO:0072015)2.06390621
121midgut development (GO:0007494)2.06027093
122negative regulation of astrocyte differentiation (GO:0048712)2.05182131
123positive regulation of dendrite morphogenesis (GO:0050775)2.04189891
124synaptic vesicle endocytosis (GO:0048488)2.04185728
125renal filtration (GO:0097205)2.04066715
126positive regulation of muscle hypertrophy (GO:0014742)2.03953264
127positive regulation of cardiac muscle hypertrophy (GO:0010613)2.03953264
128lymphangiogenesis (GO:0001946)2.03899379
129glycoprotein catabolic process (GO:0006516)2.03706853
130substrate-dependent cell migration (GO:0006929)2.03673917
131establishment or maintenance of monopolar cell polarity (GO:0061339)2.03232637
132establishment of monopolar cell polarity (GO:0061162)2.03232637
133myofibril assembly (GO:0030239)2.02714400
134regulation of neuronal synaptic plasticity (GO:0048168)2.02202873
135regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.01917253
136otic vesicle formation (GO:0030916)2.01633793
137organelle transport along microtubule (GO:0072384)2.01125772
138adherens junction assembly (GO:0034333)2.01042408
139mating behavior (GO:0007617)2.00593326
140clathrin coat assembly (GO:0048268)2.00056610
141developmental cell growth (GO:0048588)1.99891379
142retrograde transport, vesicle recycling within Golgi (GO:0000301)1.99598711
143glial cell proliferation (GO:0014009)1.99353818
144heparan sulfate proteoglycan metabolic process (GO:0030201)1.99169471
145adherens junction organization (GO:0034332)1.98641789
146positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.98438696
147chondrocyte development (GO:0002063)1.98407937
148neurotransmitter secretion (GO:0007269)1.98004622
149chemosensory behavior (GO:0007635)1.97531237
150negative regulation of catenin import into nucleus (GO:0035414)1.96946343
151suckling behavior (GO:0001967)1.96499156
152gastrulation with mouth forming second (GO:0001702)1.96486099
153very-low-density lipoprotein particle assembly (GO:0034379)1.96453923
154regulation of centrosome duplication (GO:0010824)1.96299771
155regulation of glomerular filtration (GO:0003093)1.96233363
156kidney mesenchyme development (GO:0072074)1.95992406
157limb bud formation (GO:0060174)1.95713311
158SMAD protein signal transduction (GO:0060395)1.95668104
159cell surface receptor signaling pathway involved in heart development (GO:0061311)1.95235099
160cardiac epithelial to mesenchymal transition (GO:0060317)1.94917634
161mesenchymal cell differentiation (GO:0048762)1.94864628
162G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.94398784
163negative regulation of protein localization to cell surface (GO:2000009)1.94350264
164protein localization to kinetochore (GO:0034501)1.94220858
165regulation of establishment or maintenance of cell polarity (GO:0032878)1.92574468
166Golgi to endosome transport (GO:0006895)1.91910408
167regulation of gene silencing by RNA (GO:0060966)1.90841868
168regulation of posttranscriptional gene silencing (GO:0060147)1.90841868
169regulation of gene silencing by miRNA (GO:0060964)1.90841868
170regulation of cAMP-dependent protein kinase activity (GO:2000479)1.90594343
171cardiac muscle cell development (GO:0055013)1.90180950
172acrosome assembly (GO:0001675)1.89134212
173response to follicle-stimulating hormone (GO:0032354)1.88631210
174asymmetric protein localization (GO:0008105)1.88426781
175NLS-bearing protein import into nucleus (GO:0006607)1.87758610
176regulation of cardiac muscle tissue development (GO:0055024)1.87652742
177regulation of bile acid biosynthetic process (GO:0070857)1.87590286
178pore complex assembly (GO:0046931)1.87356018
179regulation of apoptotic cell clearance (GO:2000425)1.87165044
180regulation of steroid hormone biosynthetic process (GO:0090030)1.87132426
181sarcoplasmic reticulum calcium ion transport (GO:0070296)1.84583889
182establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.83708188
183endocardial cushion development (GO:0003197)1.83168137
184cartilage morphogenesis (GO:0060536)1.82985544
185anatomical structure arrangement (GO:0048532)1.82580499
186positive regulation of cardiac muscle cell differentiation (GO:2000727)1.82354170
187anterior/posterior axis specification (GO:0009948)1.82333264
188positive regulation of heart growth (GO:0060421)1.82110368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse2.96548063
2EZH2_22144423_ChIP-Seq_EOC_Human2.72768724
3GBX2_23144817_ChIP-Seq_PC3_Human2.35705805
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.25381518
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18821631
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15258392
7FUS_26573619_Chip-Seq_HEK293_Human2.12610554
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98526404
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97984894
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96475593
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96475593
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92286886
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89933457
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85766398
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83390149
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79411627
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78661649
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77786539
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75783291
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74108288
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69100663
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67145381
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65367475
24DROSHA_22980978_ChIP-Seq_HELA_Human1.64928012
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.64537522
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.61503670
27AHR_22903824_ChIP-Seq_MCF-7_Human1.61177126
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60633061
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60601988
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58414630
31TP53_16413492_ChIP-PET_HCT116_Human1.57975402
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56930160
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.56247434
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.55282275
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54500141
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54467949
37EWS_26573619_Chip-Seq_HEK293_Human1.53417669
38* ARNT_22903824_ChIP-Seq_MCF-7_Human1.52824963
39FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51052301
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49938689
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.49345199
42AR_21909140_ChIP-Seq_LNCAP_Human1.49212641
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47580612
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.47157070
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47123891
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46059147
47SMAD4_21799915_ChIP-Seq_A2780_Human1.44894008
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.44793165
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44640474
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43662586
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.42294273
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40034754
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39575950
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38991445
55TP53_18474530_ChIP-ChIP_U2OS_Human1.38737241
56BCAT_22108803_ChIP-Seq_LS180_Human1.38712139
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37130261
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33833794
59* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32003492
60* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32003492
61* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31762354
62* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31676830
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31190511
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.30770729
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.29986671
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29640945
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28188281
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.28087545
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28071677
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.27957385
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27675955
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27348845
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25183843
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24315166
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23947923
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23368895
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20884280
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20823996
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.20584904
80VDR_22108803_ChIP-Seq_LS180_Human1.19957334
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19443142
82* TCF4_18268006_ChIP-ChIP_LS174T_Human1.17977100
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17758700
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17669584
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16932894
86RXR_22108803_ChIP-Seq_LS180_Human1.16635720
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.16428345
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16248860
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16145102
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15975593
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15480821
92CJUN_26792858_Chip-Seq_BT549_Human1.14936433
93* AR_21572438_ChIP-Seq_LNCaP_Human1.13860115
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13736356
95ZNF274_21170338_ChIP-Seq_K562_Hela1.13690766
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13644420
97* P300_19829295_ChIP-Seq_ESCs_Human1.13322450
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.13027346
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12743304
100CBP_20019798_ChIP-Seq_JUKART_Human1.12743304
101SOX9_26525672_Chip-Seq_HEART_Mouse1.12627074
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12562287
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12206764
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11853337
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11806808
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.11786135
107STAT3_23295773_ChIP-Seq_U87_Human1.11557736
108BRD4_25478319_ChIP-Seq_HGPS_Human1.11225949
109AR_19668381_ChIP-Seq_PC3_Human1.10923570
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.10879648
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.10098121
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09991022
113CLOCK_20551151_ChIP-Seq_293T_Human1.09686306
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09600871
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.09291395
116* ISL1_27105846_Chip-Seq_CPCs_Mouse1.09106370
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09080785
118TAF15_26573619_Chip-Seq_HEK293_Human1.09016448
119* RUNX2_22187159_ChIP-Seq_PCA_Human1.08970149
120AR_25329375_ChIP-Seq_VCAP_Human1.07950270
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.07591191
122* KDM2B_26808549_Chip-Seq_REH_Human1.07386181
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07343623
124ESR1_21235772_ChIP-Seq_MCF-7_Human1.07211045
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07149368
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07149368
127* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06608590
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05832570
129RNF2_27304074_Chip-Seq_NSC_Mouse1.05723745
130* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05546427
131REST_21632747_ChIP-Seq_MESCs_Mouse1.05388477
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05038439
133IGF1R_20145208_ChIP-Seq_DFB_Human1.04782443
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04526746
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04272487
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.03526847
137* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03253863
138RING1B_27294783_Chip-Seq_NPCs_Mouse1.03124074
139P53_22387025_ChIP-Seq_ESCs_Mouse1.03123361
140* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02888308
141POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02634535
142FOXO3_23340844_ChIP-Seq_DLD1_Human1.01668137
143SMAD4_21741376_ChIP-Seq_HESCs_Human1.00688097
144KDM2B_26808549_Chip-Seq_K562_Human0.99862482
145RING1B_27294783_Chip-Seq_ESCs_Mouse0.98843248
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97526041
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97421808
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94528564
149* FOXA2_19822575_ChIP-Seq_HepG2_Human0.94362692
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93366032
151TCF4_23295773_ChIP-Seq_U87_Human0.93242870
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92698452
153* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92489207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.70015931
2MP0010234_abnormal_vibrissa_follicle3.52920954
3MP0003705_abnormal_hypodermis_morpholog3.49265591
4MP0003890_abnormal_embryonic-extraembry3.46821965
5MP0009780_abnormal_chondrocyte_physiolo2.80153530
6MP0004272_abnormal_basement_membrane2.45831544
7MP0008438_abnormal_cutaneous_collagen2.24207053
8MP0005623_abnormal_meninges_morphology2.18843678
9MP0005275_abnormal_skin_tensile2.14414589
10MP0000569_abnormal_digit_pigmentation2.12121011
11MP0003880_abnormal_central_pattern2.03583534
12MP0008057_abnormal_DNA_replication2.00861143
13MP0003635_abnormal_synaptic_transmissio2.00164732
14MP0004270_analgesia1.95674899
15MP0004858_abnormal_nervous_system1.87357808
16MP0003937_abnormal_limbs/digits/tail_de1.84081816
17MP0009697_abnormal_copulation1.81919134
18MP0005187_abnormal_penis_morphology1.66658514
19MP0000537_abnormal_urethra_morphology1.62974904
20MP0002063_abnormal_learning/memory/cond1.62285472
21MP0003567_abnormal_fetal_cardiomyocyte1.58322425
22MP0005167_abnormal_blood-brain_barrier1.57823273
23MP0000778_abnormal_nervous_system1.56991621
24MP0010368_abnormal_lymphatic_system1.54190518
25MP0004885_abnormal_endolymph1.48512965
26MP0003283_abnormal_digestive_organ1.47085823
27MP0005248_abnormal_Harderian_gland1.42353312
28MP0003950_abnormal_plasma_membrane1.41256999
29MP0002697_abnormal_eye_size1.39448495
30MP0001293_anophthalmia1.39117037
31MP0001958_emphysema1.38136957
32MP0004130_abnormal_muscle_cell1.37945450
33MP0002837_dystrophic_cardiac_calcinosis1.33331496
34MP0003566_abnormal_cell_adhesion1.32527695
35MP0004185_abnormal_adipocyte_glucose1.32249314
36MP0002064_seizures1.31652461
37MP0010678_abnormal_skin_adnexa1.31020202
38MP0009250_abnormal_appendicular_skeleto1.30856631
39MP0003329_amyloid_beta_deposits1.28757520
40MP0009745_abnormal_behavioral_response1.28149264
41MP0003045_fibrosis1.27986762
42MP0005551_abnormal_eye_electrophysiolog1.27348173
43MP0003935_abnormal_craniofacial_develop1.25813272
44MP0000428_abnormal_craniofacial_morphol1.23874935
45MP0003941_abnormal_skin_development1.23388766
46MP0003091_abnormal_cell_migration1.22925178
47MP0003755_abnormal_palate_morphology1.22913746
48MP0002084_abnormal_developmental_patter1.22638772
49MP0005367_renal/urinary_system_phenotyp1.21979552
50MP0000516_abnormal_urinary_system1.21979552
51MP0002896_abnormal_bone_mineralization1.21427747
52MP0003123_paternal_imprinting1.19734533
53MP0004084_abnormal_cardiac_muscle1.18956502
54MP0003942_abnormal_urinary_system1.18904708
55MP0002233_abnormal_nose_morphology1.18337909
56MP0001879_abnormal_lymphatic_vessel1.18015753
57MP0009384_cardiac_valve_regurgitation1.17896207
58MP0009672_abnormal_birth_weight1.17636149
59MP0002572_abnormal_emotion/affect_behav1.17181348
60MP0006138_congestive_heart_failure1.16655573
61MP0009703_decreased_birth_body1.16577679
62MP0001501_abnormal_sleep_pattern1.16111773
63MP0000013_abnormal_adipose_tissue1.15545650
64MP0004484_altered_response_of1.15423667
65MP0005503_abnormal_tendon_morphology1.15411037
66MP0001915_intracranial_hemorrhage1.13942245
67MP0000762_abnormal_tongue_morphology1.13321058
68MP0002160_abnormal_reproductive_system1.12533573
69MP0010352_gastrointestinal_tract_polyps1.12150378
70MP0000383_abnormal_hair_follicle1.11795938
71MP0001286_abnormal_eye_development1.11437716
72MP0000534_abnormal_ureter_morphology1.11398037
73MP0009046_muscle_twitch1.09743620
74MP0002089_abnormal_postnatal_growth/wei1.09256306
75MP0004036_abnormal_muscle_relaxation1.08703367
76MP0005076_abnormal_cell_differentiation1.08430543
77MP0002295_abnormal_pulmonary_circulatio1.08347439
78MP0001672_abnormal_embryogenesis/_devel1.08319508
79MP0005380_embryogenesis_phenotype1.08319508
80MP0001440_abnormal_grooming_behavior1.05807058
81MP0001177_atelectasis1.05612232
82MP0005409_darkened_coat_color1.05046933
83MP0002269_muscular_atrophy1.04760355
84MP0002090_abnormal_vision1.04695070
85MP0003984_embryonic_growth_retardation1.03973548
86MP0002088_abnormal_embryonic_growth/wei1.03007495
87MP0004215_abnormal_myocardial_fiber1.02079251
88MP0000751_myopathy1.01331094
89MP0001486_abnormal_startle_reflex1.00178947
90MP0004233_abnormal_muscle_weight0.98889972
91MP0002086_abnormal_extraembryonic_tissu0.98426154
92MP0000432_abnormal_head_morphology0.97506242
93MP0004087_abnormal_muscle_fiber0.97357538
94MP0002092_abnormal_eye_morphology0.97173931
95MP0003868_abnormal_feces_composition0.96923011
96MP0003828_pulmonary_edema0.96374301
97MP0001299_abnormal_eye_distance/0.95444814
98MP0005257_abnormal_intraocular_pressure0.94869859
99MP0006054_spinal_hemorrhage0.92343649
100MP0002184_abnormal_innervation0.91850852
101MP0005360_urolithiasis0.90600829
102MP0002085_abnormal_embryonic_tissue0.90100427
103MP0002909_abnormal_adrenal_gland0.88864818
104MP0003385_abnormal_body_wall0.88283322
105MP0003252_abnormal_bile_duct0.88237481
106MP0002796_impaired_skin_barrier0.88126952
107MP0003943_abnormal_hepatobiliary_system0.87935970
108MP0009053_abnormal_anal_canal0.87303111
109MP0003861_abnormal_nervous_system0.87238362
110MP0002108_abnormal_muscle_morphology0.86971499
111MP0000566_synostosis0.86149744
112MP0000604_amyloidosis0.85911827
113MP0008775_abnormal_heart_ventricle0.85424530
114MP0003121_genomic_imprinting0.84884672
115MP0003115_abnormal_respiratory_system0.84465763
116MP0001666_abnormal_nutrient_absorption0.83668265
117MP0004197_abnormal_fetal_growth/weight/0.83596216
118MP0006072_abnormal_retinal_apoptosis0.83549340
119MP0010630_abnormal_cardiac_muscle0.83506304
120MP0004145_abnormal_muscle_electrophysio0.83460429
121MP0003191_abnormal_cellular_cholesterol0.82459849
122MP0002234_abnormal_pharynx_morphology0.82146846
123MP0000749_muscle_degeneration0.81807111
124MP0001730_embryonic_growth_arrest0.81687648
125MP0002925_abnormal_cardiovascular_devel0.81344724
126MP0005195_abnormal_posterior_eye0.80575102
127MP0005620_abnormal_muscle_contractility0.80523121
128MP0002168_other_aberrant_phenotype0.79937141
129MP0008961_abnormal_basal_metabolism0.79714823
130MP0005595_abnormal_vascular_smooth0.79591226
131MP0010386_abnormal_urinary_bladder0.79541659
132MP0003119_abnormal_digestive_system0.79338885
133MP0001661_extended_life_span0.78773704
134MP0001697_abnormal_embryo_size0.78236410
135MP0004085_abnormal_heartbeat0.78074557
136MP0002282_abnormal_trachea_morphology0.77800306
137MP0003633_abnormal_nervous_system0.76938563
138MP0003122_maternal_imprinting0.76921110
139MP0002106_abnormal_muscle_physiology0.76731037
140MP0002734_abnormal_mechanical_nocicepti0.76631075
141MP0003787_abnormal_imprinting0.76597237
142MP0002972_abnormal_cardiac_muscle0.76186223
143MP0000003_abnormal_adipose_tissue0.76108058
144MP0002882_abnormal_neuron_morphology0.75356522
145MP0004811_abnormal_neuron_physiology0.74972287
146MP0003195_calcinosis0.74838819
147MP0002109_abnormal_limb_morphology0.74215008
148MP0002116_abnormal_craniofacial_bone0.73650828
149MP0002332_abnormal_exercise_endurance0.73458119
150MP0003632_abnormal_nervous_system0.73287620
151MP0000266_abnormal_heart_morphology0.73134136
152MP0005388_respiratory_system_phenotype0.73089682
153MP0002133_abnormal_respiratory_system0.73089682
154MP0002938_white_spotting0.72892102
155MP0002114_abnormal_axial_skeleton0.72603573
156MP0000733_abnormal_muscle_development0.72345018
157MP0003279_aneurysm0.71468102
158MP0005666_abnormal_adipose_tissue0.70841132

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.55877310
2Shallow orbits (HP:0000586)3.32061273
3Focal motor seizures (HP:0011153)3.25404226
4Protrusio acetabuli (HP:0003179)2.95430749
5Cerebral aneurysm (HP:0004944)2.77055649
6Embryonal renal neoplasm (HP:0011794)2.71627103
7Focal seizures (HP:0007359)2.68383527
8Broad metatarsal (HP:0001783)2.61620956
9Syringomyelia (HP:0003396)2.60224615
10Spinal cord lesions (HP:0100561)2.60224615
11Buphthalmos (HP:0000557)2.57326626
12Cerebral inclusion bodies (HP:0100314)2.56079107
13Absent eyebrow (HP:0002223)2.44845073
14Abnormality of the lower motor neuron (HP:0002366)2.39243432
15Action tremor (HP:0002345)2.39001068
16Atrophic scars (HP:0001075)2.37220891
17Premature rupture of membranes (HP:0001788)2.37072675
18Mitral valve prolapse (HP:0001634)2.36608935
19Overgrowth (HP:0001548)2.36185343
20Nephroblastoma (Wilms tumor) (HP:0002667)2.31498399
21Aortic aneurysm (HP:0004942)2.27304791
22Turricephaly (HP:0000262)2.27115604
23Arterial tortuosity (HP:0005116)2.25381907
24Chorioretinal atrophy (HP:0000533)2.21077105
25Vascular tortuosity (HP:0004948)2.19107485
26Thyroid carcinoma (HP:0002890)2.18099649
27Right ventricular cardiomyopathy (HP:0011663)2.17742180
28Aortic dissection (HP:0002647)2.16194373
29Insidious onset (HP:0003587)2.15872436
30Termporal pattern (HP:0011008)2.15872436
31Visual hallucinations (HP:0002367)2.14365071
32Drooling (HP:0002307)2.09672381
33Excessive salivation (HP:0003781)2.09672381
34Absence seizures (HP:0002121)2.09410121
35Bronchomalacia (HP:0002780)2.08025989
36Hydroureter (HP:0000072)2.07379829
37Deep venous thrombosis (HP:0002625)2.06614888
38Coronal craniosynostosis (HP:0004440)2.04027585
39Decreased lacrimation (HP:0000633)2.03275619
40Atonic seizures (HP:0010819)2.02692235
41Ankle contracture (HP:0006466)2.01788913
42Rimmed vacuoles (HP:0003805)2.01734223
43Lymphangioma (HP:0100764)2.01201404
44Neurofibrillary tangles (HP:0002185)2.00223756
45Exotropia (HP:0000577)1.99901805
46Midline defect of the nose (HP:0004122)1.99322606
47Bifid tongue (HP:0010297)1.97797620
48Progressive cerebellar ataxia (HP:0002073)1.96393181
49Alacrima (HP:0000522)1.95466088
50Central scotoma (HP:0000603)1.94226180
51Myelomeningocele (HP:0002475)1.91999721
52Hepatoblastoma (HP:0002884)1.90965114
53Hyperventilation (HP:0002883)1.88944259
54Aneurysm (HP:0002617)1.88851873
55Dilatation of the ascending aorta (HP:0005111)1.88595625
56Abnormality of the pubic bones (HP:0003172)1.88091016
57Generalized tonic-clonic seizures (HP:0002069)1.86953518
58Dysdiadochokinesis (HP:0002075)1.85515185
59Genu recurvatum (HP:0002816)1.84814029
60Choroideremia (HP:0001139)1.83385698
61Subacute progressive viral hepatitis (HP:0006572)1.83273423
62Heterotopia (HP:0002282)1.83243834
63Limited hip movement (HP:0008800)1.83010978
64Abnormality of the left ventricular outflow tract (HP:0011103)1.82440451
65Subaortic stenosis (HP:0001682)1.82440451
66Pigmentary retinal degeneration (HP:0001146)1.82181485
67Supranuclear gaze palsy (HP:0000605)1.81120870
68Bell-shaped thorax (HP:0001591)1.80792756
69Choanal stenosis (HP:0000452)1.79587573
70Epileptic encephalopathy (HP:0200134)1.79377123
71Vertebral arch anomaly (HP:0008438)1.79328075
72Pulmonic stenosis (HP:0001642)1.78484148
73Absent eyelashes (HP:0000561)1.77414149
74Intrahepatic cholestasis (HP:0001406)1.75863311
75Dysmetric saccades (HP:0000641)1.74621925
76Macroorchidism (HP:0000053)1.74459878
77Febrile seizures (HP:0002373)1.73985635
78Long toe (HP:0010511)1.73191185
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72702989
80Short 4th metacarpal (HP:0010044)1.72702989
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72556405
82Epiphyseal dysplasia (HP:0002656)1.72484880
83Supernumerary spleens (HP:0009799)1.71153669
84Shoulder girdle muscle weakness (HP:0003547)1.71098433
85Hypoalphalipoproteinemia (HP:0003233)1.70492625
86Dialeptic seizures (HP:0011146)1.70210086
87Pancreatic islet-cell hyperplasia (HP:0004510)1.69856072
88Amblyopia (HP:0000646)1.69718378
89Severe Myopia (HP:0011003)1.68291041
90Diplopia (HP:0000651)1.67947075
91Abnormality of binocular vision (HP:0011514)1.67947075
92Scotoma (HP:0000575)1.67578244
93Genetic anticipation (HP:0003743)1.67577640
94Hyperextensible skin (HP:0000974)1.67288394
95Omphalocele (HP:0001539)1.67211667
96Increased variability in muscle fiber diameter (HP:0003557)1.67078432
97Rapidly progressive (HP:0003678)1.66693015
98Nemaline bodies (HP:0003798)1.65946880
99Hemiplegia (HP:0002301)1.65897420
100Aqueductal stenosis (HP:0002410)1.65646244
101Preaxial foot polydactyly (HP:0001841)1.63741849
102Hyporeflexia of lower limbs (HP:0002600)1.63727257
103Missing ribs (HP:0000921)1.63639037
104Cystic hygroma (HP:0000476)1.63153725
105Submucous cleft hard palate (HP:0000176)1.62977941
106Striae distensae (HP:0001065)1.62599113
107Arnold-Chiari malformation (HP:0002308)1.62227357
108Hypoplastic ischia (HP:0003175)1.61779922
109Volvulus (HP:0002580)1.61484725
110Fair hair (HP:0002286)1.61163102
111Hemiparesis (HP:0001269)1.60281398
112Abnormality of macular pigmentation (HP:0008002)1.60260191
113Type 1 muscle fiber predominance (HP:0003803)1.60119555
114Hematochezia (HP:0002573)1.59983565
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.59973050
116Muscle fiber inclusion bodies (HP:0100299)1.58485940
117Absent speech (HP:0001344)1.57898797
118Infantile muscular hypotonia (HP:0008947)1.57675369
119Wide anterior fontanel (HP:0000260)1.57621538
120Abnormal tarsal ossification (HP:0008369)1.57156273
121Difficulty running (HP:0009046)1.57126286
122Myokymia (HP:0002411)1.57006045
123Biliary tract neoplasm (HP:0100574)1.56872048
124Neoplasm of the small intestine (HP:0100833)1.56630712
125Abnormality of the 4th metacarpal (HP:0010012)1.56440978
126Increased connective tissue (HP:0009025)1.56287726
127Broad alveolar ridges (HP:0000187)1.55958814
128Enlarged kidneys (HP:0000105)1.55370639
129Achilles tendon contracture (HP:0001771)1.55283972
130Epidermoid cyst (HP:0200040)1.55164276
131Abnormality of salivation (HP:0100755)1.54925109
132Abnormality of the lumbar spine (HP:0100712)1.54221776
133Abnormality of the labia majora (HP:0012881)1.54043668
134Abnormal foot bone ossification (HP:0010675)1.53940532
135Congenital glaucoma (HP:0001087)1.53923768
136Malignant gastrointestinal tract tumors (HP:0006749)1.53435804
137Gastrointestinal carcinoma (HP:0002672)1.53435804
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.53404393
139Inappropriate behavior (HP:0000719)1.53368293
140Abnormality of the ischium (HP:0003174)1.53297375
141Transposition of the great arteries (HP:0001669)1.53049451
142Abnormal connection of the cardiac segments (HP:0011545)1.53049451
143Abnormal ventriculo-arterial connection (HP:0011563)1.53049451
144Narrow palate (HP:0000189)1.52029558
145Abnormality of the Achilles tendon (HP:0005109)1.51783390
146Mildly elevated creatine phosphokinase (HP:0008180)1.51546127
147Hypoplastic labia majora (HP:0000059)1.51467433
148Aplasia involving bones of the upper limbs (HP:0009823)1.51236583
149Aplasia of the phalanges of the hand (HP:0009802)1.51236583
150Aplasia involving bones of the extremities (HP:0009825)1.51236583
151Hand muscle atrophy (HP:0009130)1.50760995
152Curly hair (HP:0002212)1.50618322
153Vitreoretinal degeneration (HP:0000655)1.50607636
154Broad-based gait (HP:0002136)1.50555814
155Flat acetabular roof (HP:0003180)1.49810146
156Intention tremor (HP:0002080)1.49695167
157Labial hypoplasia (HP:0000066)1.49282340
158Bladder diverticulum (HP:0000015)1.49112871
159Abnormality of the calf musculature (HP:0001430)1.49054707
160Neonatal short-limb short stature (HP:0008921)1.49025205
161Hypolipoproteinemia (HP:0010981)1.48643859
162Absent hair (HP:0002298)1.48522445
163Thickened helices (HP:0000391)1.48225326
164Abnormal lung lobation (HP:0002101)1.46931054
165Prolonged partial thromboplastin time (HP:0003645)1.44834171
166Abnormality of the nasal septum (HP:0000419)1.44744191
167Osteomalacia (HP:0002749)1.43768375
168Asymmetry of the thorax (HP:0001555)1.41784309
169Abnormal auditory evoked potentials (HP:0006958)1.40904227
170Exercise-induced muscle cramps (HP:0003710)1.40797754
171Medulloblastoma (HP:0002885)1.39803507
172Cutaneous finger syndactyly (HP:0010554)1.39364159
173Soft skin (HP:0000977)1.37999000
174Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.37076899
175Abnormality of the corticospinal tract (HP:0002492)1.36809337
176Wide nose (HP:0000445)1.36177151
177Hip contracture (HP:0003273)1.36114014
178Short humerus (HP:0005792)1.36023538
179Esophageal varix (HP:0002040)1.35968135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.18820781
2TNIK2.90512376
3NTRK32.68111325
4STK38L2.43892110
5MAP3K92.40974636
6CASK2.29172204
7RIPK12.27215884
8MKNK22.18129969
9LATS12.17902304
10DDR22.07780827
11MAP3K42.05654012
12CAMK1G2.00885200
13FER1.93375405
14KSR11.87754114
15EPHB21.87161194
16RIPK41.85775737
17PLK41.83850783
18DAPK21.81184208
19MARK11.77967509
20WNK31.77063026
21ACVR1B1.73069392
22KSR21.72879633
23CAMK1D1.71525069
24PDGFRA1.68835151
25PAK61.65636983
26PRKD31.63586133
27PTK2B1.59756093
28MAP2K41.58976119
29PNCK1.58830504
30OBSCN1.57361009
31PLK21.56285483
32NTRK11.55978004
33EIF2AK31.54476628
34MKNK11.50766489
35LATS21.49072633
36FGFR21.46830975
37BMPR1B1.46548591
38TTN1.42568054
39TTK1.41517284
40MAP3K21.39747677
41PAK31.38905549
42FLT31.37208423
43FRK1.36381652
44MINK11.34675241
45PTK21.28684000
46TYRO31.28502520
47BRD41.25801973
48CAMKK11.24642850
49DMPK1.21608404
50STK391.20204691
51STK381.16935848
52TSSK61.12492943
53STK241.10097723
54PTK61.08258489
55YES11.07198549
56NLK1.06526679
57TIE11.04730592
58RET1.03582110
59MAPK131.01766447
60BRSK20.99374151
61AKT30.96617442
62PDGFRB0.94344972
63MUSK0.93840604
64RPS6KB20.92348323
65CAMKK20.91946399
66FGR0.90720773
67CDK50.90463102
68PLK30.89776552
69SGK30.89685593
70MAP3K120.89412424
71IRAK20.89288959
72MET0.87389873
73FGFR10.86053742
74SIK10.85998432
75TRIB30.84196380
76WEE10.81994389
77CDC70.81753646
78MAP2K10.80113135
79ICK0.79694845
80BCR0.79501769
81PKN20.79195763
82WNK10.78694314
83WNK40.77801568
84PRKCH0.76494075
85PDK30.75587336
86PDK40.75587336
87GRK50.75368165
88SIK20.74074066
89NTRK20.73196358
90SGK20.72702387
91CAMK2A0.71811404
92IRAK10.71365715
93NEK90.68835916
94LMTK20.68502874
95PRKCE0.68474201
96SGK10.67248903
97STK110.66941832
98SGK2230.66247156
99SGK4940.66247156
100PDK20.66011490
101TGFBR20.64747503
102MELK0.64427918
103RPS6KB10.63920233
104PRKCG0.63698617
105TGFBR10.63150301
106CSNK1G10.63078908
107BMX0.61414638
108PDPK10.61147164
109CSNK1E0.61018438
110MST1R0.60272880
111MAP2K70.60005233
112ERBB30.59768758
113CDK60.59764447
114DAPK10.57931383
115ROCK10.57308058
116MYLK0.56925897
117PAK20.55804112
118CSNK1G20.55266331
119MAP3K70.55263728
120CAMK2B0.55260674
121DYRK1A0.55258338
122ERBB20.53295267
123BMPR20.52651675
124CDK120.52279564
125SRC0.51485026
126STK30.51471485
127PIK3CA0.50385532
128OXSR10.50271443
129PRKCZ0.50166142
130FGFR30.49679868
131PBK0.49499849
132ERBB40.48818549
133CAMK40.48167228
134FYN0.47790084
135EPHA20.47410010
136MTOR0.47066230
137PRKD10.46446201
138GSK3A0.46244974
139PHKG20.46240193
140PHKG10.46240193
141CDK90.45936475
142INSR0.45761521
143CAMK2D0.45594887
144MAPK100.45428088
145BRAF0.43923444
146ROCK20.41179261
147CDK30.40970779
148PIK3CG0.40958650

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.29016161
2Long-term potentiation_Homo sapiens_hsa047201.91189305
3Nicotine addiction_Homo sapiens_hsa050331.82425279
4Phototransduction_Homo sapiens_hsa047441.74234617
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70226109
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69053203
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66885742
8Circadian entrainment_Homo sapiens_hsa047131.62680872
9Synaptic vesicle cycle_Homo sapiens_hsa047211.59649080
10Steroid biosynthesis_Homo sapiens_hsa001001.53463851
11Glutamatergic synapse_Homo sapiens_hsa047241.51445971
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51356936
13Gastric acid secretion_Homo sapiens_hsa049711.50758169
14Renin secretion_Homo sapiens_hsa049241.49471153
15Salivary secretion_Homo sapiens_hsa049701.49469818
16Circadian rhythm_Homo sapiens_hsa047101.48794729
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46003782
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45269910
19GABAergic synapse_Homo sapiens_hsa047271.44921814
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43825227
21Amphetamine addiction_Homo sapiens_hsa050311.39816409
22Complement and coagulation cascades_Homo sapiens_hsa046101.35173269
23Axon guidance_Homo sapiens_hsa043601.33487556
24Lysine degradation_Homo sapiens_hsa003101.29181780
25ECM-receptor interaction_Homo sapiens_hsa045121.29001249
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28695256
27Dopaminergic synapse_Homo sapiens_hsa047281.28319118
28Olfactory transduction_Homo sapiens_hsa047401.27255326
29Fatty acid degradation_Homo sapiens_hsa000711.26034783
30Glioma_Homo sapiens_hsa052141.22106774
31Dorso-ventral axis formation_Homo sapiens_hsa043201.21019608
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20254349
33Morphine addiction_Homo sapiens_hsa050321.19602393
34Oxytocin signaling pathway_Homo sapiens_hsa049211.18896205
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17649248
36Focal adhesion_Homo sapiens_hsa045101.17309005
37Long-term depression_Homo sapiens_hsa047301.15431146
38Insulin secretion_Homo sapiens_hsa049111.15139087
39Adherens junction_Homo sapiens_hsa045201.15136238
40GnRH signaling pathway_Homo sapiens_hsa049121.14914104
41Cholinergic synapse_Homo sapiens_hsa047251.13592669
42Propanoate metabolism_Homo sapiens_hsa006401.13014189
43Melanogenesis_Homo sapiens_hsa049161.11498291
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11451566
45Dilated cardiomyopathy_Homo sapiens_hsa054141.09983452
46mRNA surveillance pathway_Homo sapiens_hsa030151.09673092
47Estrogen signaling pathway_Homo sapiens_hsa049151.07750623
48MicroRNAs in cancer_Homo sapiens_hsa052061.06581517
49Gap junction_Homo sapiens_hsa045401.06416447
50Bile secretion_Homo sapiens_hsa049761.05826430
51Taste transduction_Homo sapiens_hsa047421.05505348
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05160734
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04413237
54cAMP signaling pathway_Homo sapiens_hsa040241.00626377
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00436340
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00345819
57Proteoglycans in cancer_Homo sapiens_hsa052051.00279690
58Type II diabetes mellitus_Homo sapiens_hsa049300.99521788
59Calcium signaling pathway_Homo sapiens_hsa040200.99514814
60Thyroid cancer_Homo sapiens_hsa052160.98070556
61Amoebiasis_Homo sapiens_hsa051460.98051255
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96098123
63Arginine biosynthesis_Homo sapiens_hsa002200.94791699
64Fatty acid metabolism_Homo sapiens_hsa012120.93621600
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91406320
66Collecting duct acid secretion_Homo sapiens_hsa049660.89731366
67mTOR signaling pathway_Homo sapiens_hsa041500.88510846
68Rap1 signaling pathway_Homo sapiens_hsa040150.88173684
69Hippo signaling pathway_Homo sapiens_hsa043900.87652519
70Pyruvate metabolism_Homo sapiens_hsa006200.86373264
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.86361791
72Serotonergic synapse_Homo sapiens_hsa047260.86272324
73Tight junction_Homo sapiens_hsa045300.85498341
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85198896
75ErbB signaling pathway_Homo sapiens_hsa040120.84678759
76Histidine metabolism_Homo sapiens_hsa003400.82466555
77Protein digestion and absorption_Homo sapiens_hsa049740.81206825
78VEGF signaling pathway_Homo sapiens_hsa043700.81098091
79Choline metabolism in cancer_Homo sapiens_hsa052310.79665279
80Vitamin B6 metabolism_Homo sapiens_hsa007500.79613866
81Basal transcription factors_Homo sapiens_hsa030220.78989522
82Cell cycle_Homo sapiens_hsa041100.78785642
83Fatty acid biosynthesis_Homo sapiens_hsa000610.78740189
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78460928
85AMPK signaling pathway_Homo sapiens_hsa041520.78262739
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78185007
87Thyroid hormone synthesis_Homo sapiens_hsa049180.77907029
88Prostate cancer_Homo sapiens_hsa052150.77436285
89Oocyte meiosis_Homo sapiens_hsa041140.76786114
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76779865
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76752076
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.74658500
93Pancreatic secretion_Homo sapiens_hsa049720.74095782
94Glucagon signaling pathway_Homo sapiens_hsa049220.71717555
95Renal cell carcinoma_Homo sapiens_hsa052110.71428492
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70521629
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.70014106
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68785409
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68520646
100Fat digestion and absorption_Homo sapiens_hsa049750.68360511
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68007108
102Small cell lung cancer_Homo sapiens_hsa052220.67162751
103Melanoma_Homo sapiens_hsa052180.67045459
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66888442
105Mineral absorption_Homo sapiens_hsa049780.65996629
106PPAR signaling pathway_Homo sapiens_hsa033200.65898454
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65686312
108Wnt signaling pathway_Homo sapiens_hsa043100.65236460
109Vitamin digestion and absorption_Homo sapiens_hsa049770.65213953
110Endometrial cancer_Homo sapiens_hsa052130.63889349
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63714674
112Ras signaling pathway_Homo sapiens_hsa040140.63484444
113TGF-beta signaling pathway_Homo sapiens_hsa043500.63110210
114Non-homologous end-joining_Homo sapiens_hsa034500.62937409
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62790443
116Starch and sucrose metabolism_Homo sapiens_hsa005000.61899356
117Hedgehog signaling pathway_Homo sapiens_hsa043400.61673867
118Selenocompound metabolism_Homo sapiens_hsa004500.61452494
119Cocaine addiction_Homo sapiens_hsa050300.61210736
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61060668
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60787277
122Arginine and proline metabolism_Homo sapiens_hsa003300.60786337
123Insulin resistance_Homo sapiens_hsa049310.60706205
124Pathways in cancer_Homo sapiens_hsa052000.60190003
125Basal cell carcinoma_Homo sapiens_hsa052170.59137583
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59132687
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58229440
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57553979
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57256501
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57188136
131RNA transport_Homo sapiens_hsa030130.56172624
132Vibrio cholerae infection_Homo sapiens_hsa051100.55195606
133Bladder cancer_Homo sapiens_hsa052190.53719429
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52982949
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.52707375
136Inositol phosphate metabolism_Homo sapiens_hsa005620.50114298
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.49253264
138Endocytosis_Homo sapiens_hsa041440.48403838
139Insulin signaling pathway_Homo sapiens_hsa049100.48097710
140Colorectal cancer_Homo sapiens_hsa052100.47909091
141Ovarian steroidogenesis_Homo sapiens_hsa049130.47117345
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.46907246

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