MAP3K4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.26837351
2nuclear pore complex assembly (GO:0051292)4.50463435
3nuclear pore organization (GO:0006999)4.32812614
4mitotic sister chromatid segregation (GO:0000070)4.23547159
5regulation of translational fidelity (GO:0006450)4.11478659
6peptidyl-lysine dimethylation (GO:0018027)4.00286959
7negative regulation of histone methylation (GO:0031061)3.79854424
8cardiac myofibril assembly (GO:0055003)3.74165609
9negative regulation of cell size (GO:0045792)3.73330456
10regulation of centriole replication (GO:0046599)3.71715375
11negative regulation of DNA repair (GO:0045738)3.65436256
12DNA synthesis involved in DNA repair (GO:0000731)3.63739391
13protein localization to chromosome, centromeric region (GO:0071459)3.61411054
14mitotic chromosome condensation (GO:0007076)3.60771719
15heterochromatin organization (GO:0070828)3.53238594
16regulation of gene silencing by RNA (GO:0060966)3.50061632
17regulation of posttranscriptional gene silencing (GO:0060147)3.50061632
18regulation of gene silencing by miRNA (GO:0060964)3.50061632
19non-recombinational repair (GO:0000726)3.49769065
20double-strand break repair via nonhomologous end joining (GO:0006303)3.49769065
21regulation of DNA endoreduplication (GO:0032875)3.48183742
22histone H3-K9 demethylation (GO:0033169)3.46064028
23synapsis (GO:0007129)3.45892004
24positive regulation of histone H3-K4 methylation (GO:0051571)3.44321942
25negative regulation of potassium ion transmembrane transport (GO:1901380)3.44086883
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.42678105
27DNA unwinding involved in DNA replication (GO:0006268)3.38169241
28paraxial mesoderm development (GO:0048339)3.37202102
29DNA replication initiation (GO:0006270)3.36445942
30metaphase plate congression (GO:0051310)3.33718456
31regulation of histone H3-K4 methylation (GO:0051569)3.30254420
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.28110329
33regulation of translation, ncRNA-mediated (GO:0045974)3.28110329
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28110329
35mitotic metaphase plate congression (GO:0007080)3.27569171
36sister chromatid cohesion (GO:0007062)3.26214728
37mitotic G2/M transition checkpoint (GO:0044818)3.25706238
38meiotic chromosome segregation (GO:0045132)3.25658453
39DNA topological change (GO:0006265)3.25245158
40monoubiquitinated protein deubiquitination (GO:0035520)3.24618019
41plasma membrane repair (GO:0001778)3.20815152
42mitotic sister chromatid cohesion (GO:0007064)3.19690016
43glucocorticoid receptor signaling pathway (GO:0042921)3.17416589
44establishment of apical/basal cell polarity (GO:0035089)3.17277517
45regulation of histone methylation (GO:0031060)3.16909240
46regulation of NFAT protein import into nucleus (GO:0051532)3.16901896
47regulation of translational termination (GO:0006449)3.16123140
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.14848499
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14848499
50histone H3-K36 demethylation (GO:0070544)3.14148268
51positive regulation of histone methylation (GO:0031062)3.11617844
52regulation of meiosis I (GO:0060631)3.11450851
53nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.11331287
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.10931021
55pore complex assembly (GO:0046931)3.10833631
56mitotic nuclear envelope disassembly (GO:0007077)3.09346804
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08647923
58insulin-like growth factor receptor signaling pathway (GO:0048009)3.08624063
59regulation of histone H3-K9 methylation (GO:0051570)3.07877744
60cellular protein complex localization (GO:0034629)3.06650674
61regulation of mitotic sister chromatid separation (GO:0010965)3.03696952
62regulation of mitotic sister chromatid segregation (GO:0033047)3.03696952
63regulation of sister chromatid segregation (GO:0033045)3.03696952
64regulation of chromosome segregation (GO:0051983)3.03085061
65regulation of RNA export from nucleus (GO:0046831)3.02837106
66carnitine shuttle (GO:0006853)3.01950323
67DNA conformation change (GO:0071103)3.01621400
68membrane disassembly (GO:0030397)3.00673869
69nuclear envelope disassembly (GO:0051081)3.00673869
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99809316
71sarcomere organization (GO:0045214)2.98641212
72interkinetic nuclear migration (GO:0022027)2.98511511
73polarized epithelial cell differentiation (GO:0030859)2.98275765
74establishment of chromosome localization (GO:0051303)2.98147008
75negative regulation of DNA recombination (GO:0045910)2.96166054
76NLS-bearing protein import into nucleus (GO:0006607)2.95803704
77positive regulation of chromosome segregation (GO:0051984)2.94501839
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.93110160
79mitotic G1 DNA damage checkpoint (GO:0031571)2.90839171
80snRNA transcription (GO:0009301)2.87804348
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.87733748
82adherens junction assembly (GO:0034333)2.87438004
83positive regulation of SMAD protein import into nucleus (GO:0060391)2.87415853
84regulation of chromatin silencing (GO:0031935)2.86589698
85regulation of growth hormone secretion (GO:0060123)2.86567057
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85288896
87regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85288896
88regulation of sister chromatid cohesion (GO:0007063)2.84946117
89kinetochore organization (GO:0051383)2.84816720
90protein localization to kinetochore (GO:0034501)2.84370595
91protein localization to chromosome (GO:0034502)2.83693756
92regulation of hippo signaling (GO:0035330)2.83207998
93protein complex localization (GO:0031503)2.83151110
94myofibril assembly (GO:0030239)2.82618541
95mitotic G2 DNA damage checkpoint (GO:0007095)2.81058193
96DNA duplex unwinding (GO:0032508)2.80556282
97negative regulation of chromosome segregation (GO:0051985)2.80336435
98regulation of gene silencing (GO:0060968)2.79985788
99DNA geometric change (GO:0032392)2.78730848
100chromosome condensation (GO:0030261)2.78388881
101mitotic spindle checkpoint (GO:0071174)2.78243265
102peptidyl-lysine trimethylation (GO:0018023)2.78038023
103chromatin assembly (GO:0031497)2.76922120
104folic acid-containing compound biosynthetic process (GO:0009396)2.76830122
105DNA replication-dependent nucleosome organization (GO:0034723)2.76795083
106DNA replication-dependent nucleosome assembly (GO:0006335)2.76795083
107negative regulation of sister chromatid segregation (GO:0033046)2.76505329
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76505329
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76505329
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76505329
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.76505329
112regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76503760
113positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76503760
114regulation of histone H3-K27 methylation (GO:0061085)2.76080342
115cytoplasmic mRNA processing body assembly (GO:0033962)2.75773505
116spindle checkpoint (GO:0031577)2.75724910
117chromosome segregation (GO:0007059)2.74155596
118regulation of mitotic spindle organization (GO:0060236)2.73040305
119cardiac muscle contraction (GO:0060048)2.72342578
120regulation of DNA methylation (GO:0044030)2.72059551
121spliceosomal tri-snRNP complex assembly (GO:0000244)2.69664753
122positive regulation of histone deacetylation (GO:0031065)2.66937977
123gene silencing (GO:0016458)2.63044459
124cell communication by electrical coupling (GO:0010644)2.60196887
125cell-substrate adherens junction assembly (GO:0007045)2.60113498
126focal adhesion assembly (GO:0048041)2.60113498
127gene silencing by RNA (GO:0031047)2.58930215
128establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.56474216
129regulation of nucleobase-containing compound transport (GO:0032239)2.56001829
130nuclear envelope organization (GO:0006998)2.55605389
131dosage compensation (GO:0007549)2.54598135
132cardiac muscle cell development (GO:0055013)2.53743486
133embryonic foregut morphogenesis (GO:0048617)2.53451451
134positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.52714480
135mitotic G1/S transition checkpoint (GO:0044819)2.52386529
136intracellular estrogen receptor signaling pathway (GO:0030520)2.51678701
137negative regulation of histone modification (GO:0031057)2.50884434
138hippo signaling (GO:0035329)2.50711914
139epithelial cell-cell adhesion (GO:0090136)2.50619580
140histone H4-K5 acetylation (GO:0043981)2.50431837
141histone H4-K8 acetylation (GO:0043982)2.50431837
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.50331490
143establishment of monopolar cell polarity (GO:0061162)2.50331490
144sister chromatid segregation (GO:0000819)2.50278130
145fatty acid transmembrane transport (GO:1902001)2.50172436
146regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49780815
147embryonic placenta development (GO:0001892)2.49154545
148histone H4-K12 acetylation (GO:0043983)2.46515976
149regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.46172901
150histone H2A monoubiquitination (GO:0035518)2.44852742
151IMP biosynthetic process (GO:0006188)2.44126518
152regulation of spindle organization (GO:0090224)2.44112280
153regulation of fatty acid beta-oxidation (GO:0031998)2.43705876
154regulation of SMAD protein import into nucleus (GO:0060390)2.43605328
155negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.42333563
156stress granule assembly (GO:0034063)2.40751473
157chromatin silencing (GO:0006342)2.40501717
158mRNA stabilization (GO:0048255)2.37364396
159RNA stabilization (GO:0043489)2.37364396
160cell communication involved in cardiac conduction (GO:0086065)2.37270199
161establishment of nucleus localization (GO:0040023)2.37048092
162cardiac cell development (GO:0055006)2.36668268
163heart morphogenesis (GO:0003007)2.34649223
164actomyosin structure organization (GO:0031032)2.34302171
165lysine metabolic process (GO:0006553)2.34218439
166lysine catabolic process (GO:0006554)2.34218439
167positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33324141
168positive regulation of mitotic sister chromatid separation (GO:1901970)2.33324141
169positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33324141
170histone H4-K16 acetylation (GO:0043984)2.32896136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.47637049
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.28905305
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31609773
4MYC_22102868_ChIP-Seq_BL_Human2.81977491
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.72812781
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.23486840
7PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.21381211
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20252535
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19835540
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18749252
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17695302
12ZNF263_19887448_ChIP-Seq_K562_Human2.12521816
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11832648
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07268556
15KDM2B_26808549_Chip-Seq_DND41_Human2.03810271
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01662690
17TCF7_22412390_ChIP-Seq_EML_Mouse1.95853849
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93207054
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.91971817
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91037535
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90658458
22AR_21909140_ChIP-Seq_LNCAP_Human1.88706430
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82830792
24ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80332921
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80228402
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.79181211
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77966445
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75371042
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74798702
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74587647
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.74431865
32CLOCK_20551151_ChIP-Seq_293T_Human1.73976377
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73620745
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71520415
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70210447
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69052325
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68983420
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67226869
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.66296172
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66221206
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65645867
42FUS_26573619_Chip-Seq_HEK293_Human1.61371474
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.59971478
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56581046
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55939698
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53594840
47VDR_21846776_ChIP-Seq_THP-1_Human1.52965916
48CIITA_25753668_ChIP-Seq_RAJI_Human1.51459669
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51090383
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50830455
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50698425
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.50036787
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49623484
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48851622
55CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47620022
56GATA1_22025678_ChIP-Seq_K562_Human1.47098732
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.45591030
58EWS_26573619_Chip-Seq_HEK293_Human1.43850969
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42144792
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41942045
61TAF15_26573619_Chip-Seq_HEK293_Human1.41929084
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41529425
63ELK1_19687146_ChIP-ChIP_HELA_Human1.40962449
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.40655320
65KDM2B_26808549_Chip-Seq_K562_Human1.40453988
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.39853370
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.39734789
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35265777
69* ATF3_27146783_Chip-Seq_COLON_Human1.34638812
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33908427
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33505011
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33341725
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32572825
74RACK7_27058665_Chip-Seq_MCF-7_Human1.32366510
75* TBX20_22328084_ChIP-Seq_HEART_Mouse1.31740945
76* TBX20_22080862_ChIP-Seq_HEART_Mouse1.31740945
77CREB1_26743006_Chip-Seq_LNCaP_Human1.30923809
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27972455
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27897645
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26527939
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25824492
82GBX2_23144817_ChIP-Seq_PC3_Human1.25629015
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.25497766
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25112186
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25099863
86* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24297932
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23573439
88LXR_22292898_ChIP-Seq_THP-1_Human1.23056686
89STAT3_23295773_ChIP-Seq_U87_Human1.21449175
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21373103
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20180643
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19969296
93* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18202329
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17624226
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17345638
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17237343
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16896675
98CHD1_26751641_Chip-Seq_LNCaP_Human1.16444970
99* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15904241
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15806332
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15418309
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13973591
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.13694138
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13658190
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13533703
106NCOR1_26117541_ChIP-Seq_K562_Human1.13244715
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12976081
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12970209
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12460958
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11867897
111POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10604100
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10129223
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09580435
114TCF4_23295773_ChIP-Seq_U87_Human1.07971801
115SMAD4_21799915_ChIP-Seq_A2780_Human1.07279426
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06765028
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06512787
118SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05851014
119TP53_22127205_ChIP-Seq_IMR90_Human1.05522654
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05317853
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03912403
122ISL1_27105846_Chip-Seq_CPCs_Mouse1.03661017
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02882877
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02648242
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.02256643
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02082133
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01775374
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01775374
129NANOG_16153702_ChIP-ChIP_HESCs_Human1.01219611
130FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00711913
131PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00542936
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.00069855
133GATA6_25053715_ChIP-Seq_YYC3_Human0.99950802
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99854567
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99854567
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99854567
137P68_20966046_ChIP-Seq_HELA_Human0.99612631
138NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99064571
139* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98802143
140P300_19829295_ChIP-Seq_ESCs_Human0.98740673
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.98607900
142* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97671471
143SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96808146
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96199962
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95722629
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95664815
147UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94761652
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94596393
149SOX9_26525672_Chip-Seq_HEART_Mouse0.92074904
150SOX2_16153702_ChIP-ChIP_HESCs_Human0.91670910
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91021151
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90813947
153TP63_19390658_ChIP-ChIP_HaCaT_Human0.90326443
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.90135068
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89043975
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88988163
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.88266223
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87417815
159TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86864556
160GF1B_26923725_Chip-Seq_HPCs_Mouse0.86729220
161TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86596691
162P300_18555785_Chip-Seq_ESCs_Mouse0.85473643
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85351228
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84752584
165PIAS1_25552417_ChIP-Seq_VCAP_Human0.84734370
166MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82503407
167NMYC_18555785_Chip-Seq_ESCs_Mouse0.82071267
168MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81918010
169EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81873781
170PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81079361
171OCT4_18555785_Chip-Seq_ESCs_Mouse0.80866026
172SALL4_22934838_ChIP-ChIP_CD34+_Human0.80484012
173TCF4_18268006_ChIP-ChIP_LS174T_Human0.80389278
174STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80127068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.04486143
2MP0003705_abnormal_hypodermis_morpholog2.98618214
3MP0002837_dystrophic_cardiac_calcinosis2.94974760
4MP0008058_abnormal_DNA_repair2.89408519
5MP0003283_abnormal_digestive_organ2.86889485
6MP0004233_abnormal_muscle_weight2.67322382
7MP0003123_paternal_imprinting2.64480617
8MP0000751_myopathy2.49033263
9MP0010352_gastrointestinal_tract_polyps2.48800742
10MP0005076_abnormal_cell_differentiation2.46124692
11MP0003646_muscle_fatigue2.31514234
12MP0003941_abnormal_skin_development2.20151371
13MP0002269_muscular_atrophy2.10940701
14MP0004036_abnormal_muscle_relaxation2.04341523
15MP0004087_abnormal_muscle_fiber2.01905586
16MP0001730_embryonic_growth_arrest1.95279017
17MP0005330_cardiomyopathy1.94754882
18MP0010630_abnormal_cardiac_muscle1.88059228
19MP0008877_abnormal_DNA_methylation1.86231334
20MP0003111_abnormal_nucleus_morphology1.84068173
21MP0002254_reproductive_system_inflammat1.83146384
22MP0003937_abnormal_limbs/digits/tail_de1.82269905
23MP0004215_abnormal_myocardial_fiber1.81750888
24MP0002009_preneoplasia1.79017959
25MP0008932_abnormal_embryonic_tissue1.79013279
26MP0008961_abnormal_basal_metabolism1.76992167
27MP0004197_abnormal_fetal_growth/weight/1.74796228
28MP0005666_abnormal_adipose_tissue1.74217719
29MP0000537_abnormal_urethra_morphology1.70817858
30MP0005670_abnormal_white_adipose1.69502140
31MP0010234_abnormal_vibrissa_follicle1.67927077
32MP0002084_abnormal_developmental_patter1.67067459
33MP0010094_abnormal_chromosome_stability1.65237112
34MP0003984_embryonic_growth_retardation1.64499646
35MP0002088_abnormal_embryonic_growth/wei1.63404793
36MP0005380_embryogenesis_phenotype1.62029582
37MP0001672_abnormal_embryogenesis/_devel1.62029582
38MP0003566_abnormal_cell_adhesion1.61950797
39MP0000747_muscle_weakness1.60336922
40MP0004185_abnormal_adipocyte_glucose1.56385964
41MP0004145_abnormal_muscle_electrophysio1.56044849
42MP0000749_muscle_degeneration1.55223355
43MP0003077_abnormal_cell_cycle1.54648705
44MP0008057_abnormal_DNA_replication1.51602547
45MP0001299_abnormal_eye_distance/1.50695923
46MP0010307_abnormal_tumor_latency1.50061015
47MP0000383_abnormal_hair_follicle1.49223299
48MP0003121_genomic_imprinting1.47885489
49MP0010678_abnormal_skin_adnexa1.44348946
50MP0001697_abnormal_embryo_size1.42528671
51MP0002086_abnormal_extraembryonic_tissu1.41768699
52MP0003890_abnormal_embryonic-extraembry1.40912716
53MP0000733_abnormal_muscle_development1.40675272
54MP0004130_abnormal_muscle_cell1.39126922
55* MP0002085_abnormal_embryonic_tissue1.38044422
56MP0004957_abnormal_blastocyst_morpholog1.35310409
57MP0005375_adipose_tissue_phenotype1.34539960
58MP0003119_abnormal_digestive_system1.33664675
59MP0008007_abnormal_cellular_replicative1.33639809
60MP0001293_anophthalmia1.33202877
61MP0001849_ear_inflammation1.31525296
62MP0009697_abnormal_copulation1.29468542
63MP0000350_abnormal_cell_proliferation1.28742439
64MP0002106_abnormal_muscle_physiology1.27386064
65MP0003567_abnormal_fetal_cardiomyocyte1.26466260
66MP0001661_extended_life_span1.25247962
67MP0000759_abnormal_skeletal_muscle1.25189568
68MP0008775_abnormal_heart_ventricle1.25076112
69MP0005623_abnormal_meninges_morphology1.25032979
70MP0002697_abnormal_eye_size1.22492832
71MP0009672_abnormal_birth_weight1.21567056
72MP0000003_abnormal_adipose_tissue1.20034318
73* MP0002080_prenatal_lethality1.19906213
74MP0000266_abnormal_heart_morphology1.19090806
75MP0010030_abnormal_orbit_morphology1.18396222
76MP0003221_abnormal_cardiomyocyte_apopto1.18102829
77* MP0001929_abnormal_gametogenesis1.14728368
78MP0001984_abnormal_olfaction1.14380178
79MP0003115_abnormal_respiratory_system1.13780596
80MP0000428_abnormal_craniofacial_morphol1.13757773
81MP0000750_abnormal_muscle_regeneration1.13732857
82MP0001544_abnormal_cardiovascular_syste1.12860071
83MP0005385_cardiovascular_system_phenoty1.12860071
84MP0002233_abnormal_nose_morphology1.11951875
85MP0004808_abnormal_hematopoietic_stem1.11546172
86MP0006138_congestive_heart_failure1.11338625
87MP0002925_abnormal_cardiovascular_devel1.08048695
88* MP0002210_abnormal_sex_determination1.07803492
89MP0002234_abnormal_pharynx_morphology1.07568941
90MP0003137_abnormal_impulse_conducting1.07477654
91MP0003045_fibrosis1.07292407
92MP0009053_abnormal_anal_canal1.06772273
93MP0003786_premature_aging1.06730313
94MP0003656_abnormal_erythrocyte_physiolo1.06432935
95MP0002653_abnormal_ependyma_morphology1.06095774
96MP0000432_abnormal_head_morphology1.05367888
97MP0005451_abnormal_body_composition1.05017325
98MP0005369_muscle_phenotype1.04968466
99MP0000566_synostosis1.04835583
100MP0003943_abnormal_hepatobiliary_system1.04643158
101MP0004264_abnormal_extraembryonic_tissu1.03988595
102MP0009703_decreased_birth_body1.02855041
103MP0002972_abnormal_cardiac_muscle1.02351250
104MP0005620_abnormal_muscle_contractility1.01909107
105MP0005187_abnormal_penis_morphology1.01220078
106MP0002396_abnormal_hematopoietic_system1.00288409
107MP0009278_abnormal_bone_marrow0.98833751
108MP0008995_early_reproductive_senescence0.97193486
109MP0003935_abnormal_craniofacial_develop0.96329207
110MP0000313_abnormal_cell_death0.95667735
111MP0001286_abnormal_eye_development0.95335611
112MP0004272_abnormal_basement_membrane0.95317066
113MP0003300_gastrointestinal_ulcer0.95002451
114MP0009780_abnormal_chondrocyte_physiolo0.94908536
115* MP0001145_abnormal_male_reproductive0.93331722
116MP0000647_abnormal_sebaceous_gland0.91790098
117MP0003693_abnormal_embryo_hatching0.89076315
118MP0003122_maternal_imprinting0.88110498
119MP0002127_abnormal_cardiovascular_syste0.87403018
120MP0003787_abnormal_imprinting0.87337841
121MP0010368_abnormal_lymphatic_system0.87073009
122MP0002877_abnormal_melanocyte_morpholog0.86734560
123MP0002108_abnormal_muscle_morphology0.86506694
124MP0005647_abnormal_sex_gland0.86387704
125MP0005023_abnormal_wound_healing0.86011382
126* MP0002111_abnormal_tail_morphology0.84314474
127MP0005621_abnormal_cell_physiology0.84052429
128* MP0003385_abnormal_body_wall0.83959447
129* MP0000653_abnormal_sex_gland0.83902874
130MP0003878_abnormal_ear_physiology0.83681814
131MP0005377_hearing/vestibular/ear_phenot0.83681814
132* MP0003861_abnormal_nervous_system0.83572134
133MP0001915_intracranial_hemorrhage0.83450750
134MP0005266_abnormal_metabolism0.82249415
135MP0005394_taste/olfaction_phenotype0.79697830
136MP0005499_abnormal_olfactory_system0.79697830
137MP0000569_abnormal_digit_pigmentation0.79415035
138MP0003718_maternal_effect0.78527443
139* MP0003698_abnormal_male_reproductive0.78447196
140MP0002909_abnormal_adrenal_gland0.78343940
141MP0005384_cellular_phenotype0.77799503
142MP0002128_abnormal_blood_circulation0.76307689
143MP0000427_abnormal_hair_cycle0.73780286
144MP0001727_abnormal_embryo_implantation0.71887871
145MP0005248_abnormal_Harderian_gland0.70633809
146MP0001119_abnormal_female_reproductive0.69341013
147* MP0001784_abnormal_fluid_regulation0.69289966
148MP0003699_abnormal_female_reproductive0.68883521
149MP0000579_abnormal_nail_morphology0.68881875
150MP0000462_abnormal_digestive_system0.67471994
151MP0002092_abnormal_eye_morphology0.66789983
152MP0005220_abnormal_exocrine_pancreas0.62351794
153MP0000631_abnormal_neuroendocrine_gland0.62234790

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.43303638
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18363909
3Ependymoma (HP:0002888)3.94235962
4Papillary thyroid carcinoma (HP:0002895)3.64350110
5Hyperacusis (HP:0010780)3.47255306
6Cortical dysplasia (HP:0002539)3.39785354
7Astrocytoma (HP:0009592)3.33081489
8Abnormality of the astrocytes (HP:0100707)3.33081489
9Volvulus (HP:0002580)3.28451041
10Cerebral aneurysm (HP:0004944)3.09434599
11Ankyloglossia (HP:0010296)3.04450522
12Nephroblastoma (Wilms tumor) (HP:0002667)2.99513367
13Embryonal renal neoplasm (HP:0011794)2.95615500
14Increased connective tissue (HP:0009025)2.94773243
15Sudden death (HP:0001699)2.90430618
16Acute myeloid leukemia (HP:0004808)2.85586494
17Hepatoblastoma (HP:0002884)2.85126731
18Overlapping toe (HP:0001845)2.80652544
19Elfin facies (HP:0004428)2.80074599
20Abnormality of the lower motor neuron (HP:0002366)2.79128543
21Renovascular hypertension (HP:0100817)2.78317091
22Renal duplication (HP:0000075)2.75523467
23Exercise-induced muscle cramps (HP:0003710)2.74945588
24Hypoplastic labia majora (HP:0000059)2.73708680
25Right ventricular cardiomyopathy (HP:0011663)2.72816378
26Hand muscle atrophy (HP:0009130)2.70522489
27Hyporeflexia of lower limbs (HP:0002600)2.70083620
28Abnormality of chromosome stability (HP:0003220)2.69364660
29Ectopic kidney (HP:0000086)2.67578329
30Distal upper limb amyotrophy (HP:0007149)2.64990986
31Upper limb amyotrophy (HP:0009129)2.64990986
32Lymphangioma (HP:0100764)2.64032464
33Difficulty running (HP:0009046)2.60913822
34Aplasia/Hypoplasia of the sternum (HP:0006714)2.59549651
35Ventricular tachycardia (HP:0004756)2.57313696
36Metaphyseal cupping (HP:0003021)2.57186374
37Glioma (HP:0009733)2.50002886
38Short 4th metacarpal (HP:0010044)2.49469612
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49469612
40Abnormality of the labia majora (HP:0012881)2.48213363
41Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.47789831
42Bundle branch block (HP:0011710)2.44995540
43Neoplasm of the small intestine (HP:0100833)2.42025874
44Increased nuchal translucency (HP:0010880)2.41892190
45Short middle phalanx of the 5th finger (HP:0004220)2.41456527
46Progressive external ophthalmoplegia (HP:0000590)2.41035510
47Neoplasm of striated muscle (HP:0009728)2.38299831
48Dysmetric saccades (HP:0000641)2.37216161
49Subaortic stenosis (HP:0001682)2.36913473
50Abnormality of the left ventricular outflow tract (HP:0011103)2.36913473
51Abnormality of oral frenula (HP:0000190)2.35653825
52Myoglobinuria (HP:0002913)2.34504299
53Truncal obesity (HP:0001956)2.33495607
54Exercise-induced myalgia (HP:0003738)2.33480648
55Abnormality of the 4th metacarpal (HP:0010012)2.33075710
56Abnormality of the labia minora (HP:0012880)2.28386249
57Overriding aorta (HP:0002623)2.28216683
58Macroorchidism (HP:0000053)2.28133613
59Thyroid carcinoma (HP:0002890)2.28128491
60Insomnia (HP:0100785)2.26961336
61Difficulty climbing stairs (HP:0003551)2.26030787
62Gastrointestinal carcinoma (HP:0002672)2.25832769
63Malignant gastrointestinal tract tumors (HP:0006749)2.25832769
64Aneurysm (HP:0002617)2.25232438
65Calf muscle hypertrophy (HP:0008981)2.25191641
66Aplasia/Hypoplasia of the earlobes (HP:0009906)2.22764730
67Anal stenosis (HP:0002025)2.21726371
68Pseudobulbar signs (HP:0002200)2.17556536
69Shallow orbits (HP:0000586)2.16346342
70Pointed chin (HP:0000307)2.14484039
71Atrial fibrillation (HP:0005110)2.13529250
72Hamartoma of the eye (HP:0010568)2.13306467
73Absent radius (HP:0003974)2.12783230
74Gonadotropin excess (HP:0000837)2.12149931
75EMG: neuropathic changes (HP:0003445)2.11738680
76Neoplasm of the heart (HP:0100544)2.11076902
77Abnormality of chromosome segregation (HP:0002916)2.10050463
78Scapular winging (HP:0003691)2.09851837
79Bowel diverticulosis (HP:0005222)2.09313217
80Abnormality of the salivary glands (HP:0010286)2.08803704
81Bladder diverticulum (HP:0000015)2.07366265
82Cystic hygroma (HP:0000476)2.06884366
83Abnormal hair whorl (HP:0010721)2.05404661
84Asymmetric septal hypertrophy (HP:0001670)2.05210664
85Short middle phalanx of finger (HP:0005819)2.04394368
86Abnormal lung lobation (HP:0002101)2.04365773
87Medulloblastoma (HP:0002885)2.04233069
88Ventricular arrhythmia (HP:0004308)2.04181415
89Fibroma (HP:0010614)2.03557673
90Neoplasm of the oral cavity (HP:0100649)2.03230361
91Muscle hypertrophy of the lower extremities (HP:0008968)2.03175712
92Heterotopia (HP:0002282)2.02379927
93Cafe-au-lait spot (HP:0000957)2.01991975
94Pelvic girdle muscle weakness (HP:0003749)2.01674235
95Abnormality of the calf musculature (HP:0001430)2.01506595
96Limb-girdle muscle atrophy (HP:0003797)1.99815698
97Adenoma sebaceum (HP:0009720)1.98776700
98Angiofibromas (HP:0010615)1.98776700
99Fibrous tissue neoplasm (HP:0012316)1.97704606
100Primary atrial arrhythmia (HP:0001692)1.97381962
101Abnormality of abdominal situs (HP:0011620)1.96314980
102Abdominal situs inversus (HP:0003363)1.96314980
103Bowel incontinence (HP:0002607)1.96138998
104Flat cornea (HP:0007720)1.95220205
105Rhabdomyosarcoma (HP:0002859)1.94923080
106Double outlet right ventricle (HP:0001719)1.94502695
107Congenital malformation of the right heart (HP:0011723)1.94502695
108Deep philtrum (HP:0002002)1.93928453
109Hypoplastic ischia (HP:0003175)1.93735798
110Muscle fiber splitting (HP:0003555)1.93293375
111Cutaneous syndactyly (HP:0012725)1.93166590
112Obsessive-compulsive behavior (HP:0000722)1.93003196
113Agnosia (HP:0010524)1.91715989
114Broad palm (HP:0001169)1.91650816
115High pitched voice (HP:0001620)1.91633343
116Abnormal pancreas size (HP:0012094)1.90195753
117Labial hypoplasia (HP:0000066)1.90136118
118Abnormality of the fingertips (HP:0001211)1.89609888
119Enlarged penis (HP:0000040)1.89167462
120Sandal gap (HP:0001852)1.89160401
121Supraventricular arrhythmia (HP:0005115)1.88833362
122Ventricular fibrillation (HP:0001663)1.88006485
123Colon cancer (HP:0003003)1.87640422
124Ankle contracture (HP:0006466)1.87546392
125Cutaneous finger syndactyly (HP:0010554)1.87045231
126Intestinal atresia (HP:0011100)1.86438634
127Long eyelashes (HP:0000527)1.86190642
128Supraventricular tachycardia (HP:0004755)1.86136083
129Aplasia involving forearm bones (HP:0009822)1.86083899
130Absent forearm bone (HP:0003953)1.86083899
131Menstrual irregularities (HP:0000858)1.86033254
132Shoulder girdle muscle weakness (HP:0003547)1.85470897
133Clitoromegaly (HP:0000057)1.82868834
134Sloping forehead (HP:0000340)1.82074043
135Urethral obstruction (HP:0000796)1.80400651
136Abnormal biliary tract morphology (HP:0012440)1.80002108
137Deviation of the thumb (HP:0009603)1.79340849
138Embryonal neoplasm (HP:0002898)1.79109279
139Protruding tongue (HP:0010808)1.78786858
140Absent eyebrow (HP:0002223)1.78240317
141Diastasis recti (HP:0001540)1.77657072
142Duplicated collecting system (HP:0000081)1.77561840
143Abnormality of the duodenum (HP:0002246)1.77368818
144Proximal placement of thumb (HP:0009623)1.76695038
145Abnormality of the antihelix (HP:0009738)1.76369507
146Hypoplastic female external genitalia (HP:0012815)1.75963837
147Prominent nose (HP:0000448)1.75902495
148Lipoatrophy (HP:0100578)1.75662338
149Tubulointerstitial nephritis (HP:0001970)1.75280237
150Abnormal large intestine physiology (HP:0012700)1.75209347
151Duodenal stenosis (HP:0100867)1.74197882
152Small intestinal stenosis (HP:0012848)1.74197882
153Megalocornea (HP:0000485)1.72580167
154Hypopigmentation of the fundus (HP:0007894)1.72457682
155Broad thumb (HP:0011304)1.72336006
156Low anterior hairline (HP:0000294)1.71496398
157Bilateral microphthalmos (HP:0007633)1.71138814
158Subacute progressive viral hepatitis (HP:0006572)1.71048730
159Trigonocephaly (HP:0000243)1.70624407
160Short phalanx of the thumb (HP:0009660)1.70374985
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70355974
162Proximal amyotrophy (HP:0007126)1.70304217
163Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70028383
164Leiomyosarcoma (HP:0100243)1.69876311
165Uterine leiomyosarcoma (HP:0002891)1.69876311
166Rimmed vacuoles (HP:0003805)1.69324917
167Missing ribs (HP:0000921)1.68950179
168Abnormality of the diencephalon (HP:0010662)1.68693316
169Rhabdomyolysis (HP:0003201)1.68624095
170Shawl scrotum (HP:0000049)1.68429516
171Biliary tract neoplasm (HP:0100574)1.67819120
172Spinal muscular atrophy (HP:0007269)1.67770476
173Pancreatic islet-cell hyperplasia (HP:0004510)1.67732553
174EMG: myopathic abnormalities (HP:0003458)1.67188917
175Abnormality of the preputium (HP:0100587)1.66880452
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66853221
177Choanal atresia (HP:0000453)1.66403600
178Skull defect (HP:0001362)1.66256930
179Transitional cell carcinoma of the bladder (HP:0006740)1.65480918
180Syncope (HP:0001279)1.64448803
181Resting tremor (HP:0002322)1.64216942
182Abnormality of the ischium (HP:0003174)1.62170315
183Rectal prolapse (HP:0002035)1.62079041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.46060807
2CDK123.45949571
3EEF2K3.33990331
4TRIB33.26523745
5TTN2.86800560
6MKNK22.80876428
7NEK12.79270320
8MAP3K102.48604403
9MKNK12.31717595
10RIPK12.15705528
11PLK42.14240722
12ICK2.11355609
13CAMK1D2.03263185
14TNIK2.00211212
15CDC71.99519217
16LATS11.99249849
17SRPK11.98139134
18PDGFRA1.79082126
19NEK21.72297402
20SCYL21.68956944
21PTK61.65525397
22CAMK1G1.65006306
23MTOR1.63091891
24PASK1.62070693
25RPS6KB21.52113563
26EIF2AK11.46408468
27BRSK21.41067588
28TAF11.39396188
29SIK11.35064385
30PRKD31.33306523
31LATS21.33159488
32EIF2AK31.33110649
33CLK11.30746435
34LMTK21.29825507
35TTK1.27030369
36DMPK1.26569813
37FGFR31.25766834
38ALK1.24541162
39PAK41.23985959
40TYRO31.23294430
41CDK41.21447814
42NLK1.20352941
43ACVR1B1.18586972
44BMPR1B1.17748585
45BRD41.13825893
46BMX1.09925633
47ZAK1.09161105
48PLK31.07509152
49AKT31.07083153
50MST41.07005872
51PDK31.02307874
52PDK41.02307874
53STK241.01474934
54MAP3K90.98116148
55CHEK20.93787098
56STK380.92614055
57MAP3K70.91493641
58PAK60.90879031
59TAOK10.88956458
60CHEK10.85814891
61MAP3K80.85168427
62RET0.84484305
63ERBB30.83212074
64CDK60.83022448
65PBK0.82285491
66KSR20.80209419
67ATR0.79081461
68MAP3K140.78005354
69CDC42BPA0.77820045
70TGFBR10.76382762
71FGFR10.76189984
72CDK90.75884028
73RAF10.75208748
74PHKG20.74763041
75PHKG10.74763041
76TRPM70.74705236
77NEK90.74279498
78MAP3K20.73735957
79MAP2K30.73360203
80EPHA20.72841316
81PDGFRB0.71752969
82STK100.71592503
83SGK20.71236249
84CDK30.71181340
85BCKDK0.70604429
86STK40.70229968
87FER0.70172789
88CAMKK10.68589399
89BUB10.68394734
90CDK20.67952770
91LRRK20.66819614
92MAP3K130.66056756
93OBSCN0.65417533
94SGK30.65412507
95FLT30.65355298
96PRKAA10.64788006
97EIF2AK20.64401798
98BCR0.64317253
99PAK30.63504667
100YES10.61909990
101ATM0.61861633
102WNK10.61466269
103SGK10.61369958
104RPS6KB10.60944534
105KSR10.60137704
106PLK10.59626821
107PAK20.59539331
108CDK70.59336878
109WEE10.58625534
110PTK20.57447898
111STK30.57152867
112MELK0.57030858
113AURKB0.57030511
114MAP3K30.55729673
115TSSK60.55635017
116CASK0.55630973
117BRAF0.55210371
118* MAP3K40.55011516
119DDR20.54833170
120AKT20.54635147
121FGR0.52908093
122CDK190.52342516
123PIM10.51277313
124MAP3K60.51009973
125CDK10.50640368
126RPS6KA40.50437151
127MARK30.50335046
128FGFR40.50323384
129MET0.49097910
130CSNK1E0.48823219
131PRKDC0.48294234
132CAMK40.48261548
133STK38L0.46155200
134PNCK0.45903370
135CSNK1D0.44704855
136PRKD10.44405103
137MAPK140.43644245
138STK110.43517341
139ERBB20.43175938
140GSK3B0.41696460
141RPS6KA10.41413371
142MAPK100.40185636
143PRKCH0.38941571
144FGFR20.38660992

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.40667089
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.78713420
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.65730917
4Lysine degradation_Homo sapiens_hsa003102.49431771
5Nitrogen metabolism_Homo sapiens_hsa009102.11356121
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03096898
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01603889
8mTOR signaling pathway_Homo sapiens_hsa041501.94405334
9Fanconi anemia pathway_Homo sapiens_hsa034601.92628919
10Dilated cardiomyopathy_Homo sapiens_hsa054141.84906929
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69555633
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.65376155
13One carbon pool by folate_Homo sapiens_hsa006701.61973784
14Base excision repair_Homo sapiens_hsa034101.61519158
15Nucleotide excision repair_Homo sapiens_hsa034201.56969068
16Biosynthesis of amino acids_Homo sapiens_hsa012301.56621992
17Homologous recombination_Homo sapiens_hsa034401.56194880
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53781371
19RNA degradation_Homo sapiens_hsa030181.52729574
20Carbon metabolism_Homo sapiens_hsa012001.52503923
21mRNA surveillance pathway_Homo sapiens_hsa030151.50847242
22Adherens junction_Homo sapiens_hsa045201.48075662
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.47587833
24Circadian rhythm_Homo sapiens_hsa047101.46128178
25Basal transcription factors_Homo sapiens_hsa030221.42758161
26Insulin resistance_Homo sapiens_hsa049311.41494750
27Prostate cancer_Homo sapiens_hsa052151.39767526
28Pancreatic cancer_Homo sapiens_hsa052121.37568692
29RNA transport_Homo sapiens_hsa030131.36343736
30Mismatch repair_Homo sapiens_hsa034301.35503700
31Glucagon signaling pathway_Homo sapiens_hsa049221.33898396
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33762446
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31862542
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30983142
35AMPK signaling pathway_Homo sapiens_hsa041521.28017024
36Fatty acid degradation_Homo sapiens_hsa000711.25995099
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23923085
38Cell cycle_Homo sapiens_hsa041101.21621089
39Propanoate metabolism_Homo sapiens_hsa006401.21046543
40Type II diabetes mellitus_Homo sapiens_hsa049301.19356840
41Hippo signaling pathway_Homo sapiens_hsa043901.18584286
42MicroRNAs in cancer_Homo sapiens_hsa052061.17261756
43Insulin signaling pathway_Homo sapiens_hsa049101.16758865
44Arginine biosynthesis_Homo sapiens_hsa002201.15541816
45Oocyte meiosis_Homo sapiens_hsa041141.15398312
46Basal cell carcinoma_Homo sapiens_hsa052171.13823698
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12819017
48Focal adhesion_Homo sapiens_hsa045101.10978466
49Alcoholism_Homo sapiens_hsa050341.10457262
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09423020
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09320368
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06877715
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06510490
54Fatty acid metabolism_Homo sapiens_hsa012121.05710221
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05081912
56ErbB signaling pathway_Homo sapiens_hsa040121.04978452
57Proteoglycans in cancer_Homo sapiens_hsa052051.02807880
58Tight junction_Homo sapiens_hsa045301.02101071
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01969368
60Acute myeloid leukemia_Homo sapiens_hsa052211.01404199
61Endometrial cancer_Homo sapiens_hsa052131.00435677
62DNA replication_Homo sapiens_hsa030301.00252261
63HIF-1 signaling pathway_Homo sapiens_hsa040660.97327609
64Chronic myeloid leukemia_Homo sapiens_hsa052200.94446398
65Glioma_Homo sapiens_hsa052140.91880777
66Non-small cell lung cancer_Homo sapiens_hsa052230.91407639
67Pyruvate metabolism_Homo sapiens_hsa006200.91205953
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89795773
69Small cell lung cancer_Homo sapiens_hsa052220.89680135
70Dorso-ventral axis formation_Homo sapiens_hsa043200.89207955
71Hedgehog signaling pathway_Homo sapiens_hsa043400.88407267
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88401454
73p53 signaling pathway_Homo sapiens_hsa041150.88264707
74Selenocompound metabolism_Homo sapiens_hsa004500.88168637
75Notch signaling pathway_Homo sapiens_hsa043300.87681142
76Choline metabolism in cancer_Homo sapiens_hsa052310.87295964
77Thyroid cancer_Homo sapiens_hsa052160.86703506
78Bile secretion_Homo sapiens_hsa049760.86688983
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85392977
80Prolactin signaling pathway_Homo sapiens_hsa049170.84532474
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80311326
82Viral myocarditis_Homo sapiens_hsa054160.79503515
83Steroid biosynthesis_Homo sapiens_hsa001000.77838404
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77380365
85Estrogen signaling pathway_Homo sapiens_hsa049150.76660495
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.76515066
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76044462
88Galactose metabolism_Homo sapiens_hsa000520.75989667
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74750211
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74175719
91Fatty acid biosynthesis_Homo sapiens_hsa000610.73931246
92ECM-receptor interaction_Homo sapiens_hsa045120.73137885
93FoxO signaling pathway_Homo sapiens_hsa040680.72654213
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71987698
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69079994
96HTLV-I infection_Homo sapiens_hsa051660.68059234
97Colorectal cancer_Homo sapiens_hsa052100.67942680
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67935270
99Long-term potentiation_Homo sapiens_hsa047200.67617385
100Renal cell carcinoma_Homo sapiens_hsa052110.66307699
101TGF-beta signaling pathway_Homo sapiens_hsa043500.65985847
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.65963426
103Gap junction_Homo sapiens_hsa045400.65802767
104B cell receptor signaling pathway_Homo sapiens_hsa046620.65713959
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.65220735
106Fructose and mannose metabolism_Homo sapiens_hsa000510.64009204
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63765878
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63179863
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63169500
110Cardiac muscle contraction_Homo sapiens_hsa042600.62287156
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61675521
112Butanoate metabolism_Homo sapiens_hsa006500.61582266
113Viral carcinogenesis_Homo sapiens_hsa052030.60395698
114Inositol phosphate metabolism_Homo sapiens_hsa005620.60104406
115VEGF signaling pathway_Homo sapiens_hsa043700.59997404
116Oxytocin signaling pathway_Homo sapiens_hsa049210.59891345
117Melanoma_Homo sapiens_hsa052180.59101352
118PPAR signaling pathway_Homo sapiens_hsa033200.57058075
119Insulin secretion_Homo sapiens_hsa049110.56642283
120Herpes simplex infection_Homo sapiens_hsa051680.56180450
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56029041
122Melanogenesis_Homo sapiens_hsa049160.55745044
123Systemic lupus erythematosus_Homo sapiens_hsa053220.52266345
124Spliceosome_Homo sapiens_hsa030400.51563846
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.50999521
126Hepatitis B_Homo sapiens_hsa051610.50650511
127Wnt signaling pathway_Homo sapiens_hsa043100.50570621
128Gastric acid secretion_Homo sapiens_hsa049710.50482112
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.49061529
130Pathways in cancer_Homo sapiens_hsa052000.48417302
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45718658
132Measles_Homo sapiens_hsa051620.45319584
133Sphingolipid metabolism_Homo sapiens_hsa006000.44086162
134Long-term depression_Homo sapiens_hsa047300.43804024
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.42179877
136T cell receptor signaling pathway_Homo sapiens_hsa046600.41076789
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.40837817
138Epstein-Barr virus infection_Homo sapiens_hsa051690.38483988
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.37231721
140Rap1 signaling pathway_Homo sapiens_hsa040150.36052553
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.35164020

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