MAP3K15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPII vesicle coating (GO:0048208)6.59641720
2endocrine pancreas development (GO:0031018)6.58615677
3peptide hormone processing (GO:0016486)6.53312667
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.52059297
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.39760683
6glandular epithelial cell differentiation (GO:0002067)6.19999047
7L-alpha-amino acid transmembrane transport (GO:1902475)6.02561988
8type B pancreatic cell development (GO:0003323)5.83916731
9protein retention in ER lumen (GO:0006621)5.64994670
10glandular epithelial cell development (GO:0002068)5.50291774
11protein maturation by protein folding (GO:0022417)5.47522003
12macroautophagy (GO:0016236)5.38185519
13positive regulation of insulin secretion (GO:0032024)5.26999273
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.99475769
15insulin secretion (GO:0030073)4.95261072
16vesicle coating (GO:0006901)4.84290460
17positive regulation of nuclease activity (GO:0032075)4.75325941
18sequestering of metal ion (GO:0051238)4.72756384
19positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.72319619
20behavioral response to nicotine (GO:0035095)4.40112978
21regulation of nuclease activity (GO:0032069)4.36400372
22cellular response to vitamin D (GO:0071305)4.33684788
23water-soluble vitamin biosynthetic process (GO:0042364)4.29760202
24regulation of insulin secretion (GO:0050796)4.24663063
25columnar/cuboidal epithelial cell development (GO:0002066)4.22972274
26L-fucose catabolic process (GO:0042355)4.22727959
27fucose catabolic process (GO:0019317)4.22727959
28L-fucose metabolic process (GO:0042354)4.22727959
29protein autoprocessing (GO:0016540)4.22484304
30positive regulation of peptide hormone secretion (GO:0090277)4.18520143
31regulation of type B pancreatic cell apoptotic process (GO:2000674)4.14288515
32signal peptide processing (GO:0006465)4.09276947
33endoplasmic reticulum unfolded protein response (GO:0030968)4.08611116
34exocrine pancreas development (GO:0031017)4.06396166
35regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.06295243
36cellular response to topologically incorrect protein (GO:0035967)4.03447538
37cellular response to unfolded protein (GO:0034620)4.03327214
38epithelial cell fate commitment (GO:0072148)4.02961332
39positive regulation of peptide secretion (GO:0002793)4.01825974
40peptide hormone secretion (GO:0030072)4.01016702
41cellular ketone body metabolic process (GO:0046950)3.98146167
42peptide secretion (GO:0002790)3.93923078
43ER-nucleus signaling pathway (GO:0006984)3.85850214
44toxin metabolic process (GO:0009404)3.83782649
45regulation of peptide hormone secretion (GO:0090276)3.81125543
46regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.78178148
47positive regulation of hormone biosynthetic process (GO:0046886)3.75042098
48regulation of peptide secretion (GO:0002791)3.73867781
49ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.66869897
50regulation of male gonad development (GO:2000018)3.64857460
51detection of calcium ion (GO:0005513)3.64328098
52piRNA metabolic process (GO:0034587)3.63732476
53intra-Golgi vesicle-mediated transport (GO:0006891)3.63151787
54ketone body metabolic process (GO:1902224)3.61318170
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59557483
56nitric oxide mediated signal transduction (GO:0007263)3.54191669
57astrocyte differentiation (GO:0048708)3.49542899
58positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.49282723
59ER overload response (GO:0006983)3.48120083
60positive regulation of vesicle fusion (GO:0031340)3.47441332
61estrogen biosynthetic process (GO:0006703)3.46883999
62negative regulation of digestive system process (GO:0060457)3.45230019
63cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.41420056
64platelet dense granule organization (GO:0060155)3.40591535
65protein N-linked glycosylation via asparagine (GO:0018279)3.39991714
66respiratory chain complex IV assembly (GO:0008535)3.39326634
67peptidyl-asparagine modification (GO:0018196)3.38269564
68cellular response to hepatocyte growth factor stimulus (GO:0035729)3.37842530
69response to hepatocyte growth factor (GO:0035728)3.37842530
70response to pheromone (GO:0019236)3.36184205
71response to endoplasmic reticulum stress (GO:0034976)3.32646373
72nonmotile primary cilium assembly (GO:0035058)3.29825429
73ER to Golgi vesicle-mediated transport (GO:0006888)3.28042251
74negative regulation of bone resorption (GO:0045779)3.27548364
75growth hormone secretion (GO:0030252)3.27526742
76negative regulation of JUN kinase activity (GO:0043508)3.27466036
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27268002
78regulation of hormone secretion (GO:0046883)3.25301515
79regulation of Golgi to plasma membrane protein transport (GO:0042996)3.24502216
80negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24390590
81protein polyglutamylation (GO:0018095)3.24004154
82negative regulation of hormone metabolic process (GO:0032351)3.23190073
83negative regulation of hormone biosynthetic process (GO:0032353)3.23190073
84peptide transport (GO:0015833)3.22595161
85detection of light stimulus involved in visual perception (GO:0050908)3.22288765
86detection of light stimulus involved in sensory perception (GO:0050962)3.22288765
87indolalkylamine metabolic process (GO:0006586)3.22253643
88indole-containing compound catabolic process (GO:0042436)3.21855788
89indolalkylamine catabolic process (GO:0046218)3.21855788
90tryptophan catabolic process (GO:0006569)3.21855788
91benzene-containing compound metabolic process (GO:0042537)3.21620292
92positive regulation of hormone secretion (GO:0046887)3.20644818
93nephron tubule morphogenesis (GO:0072078)3.18848504
94nephron epithelium morphogenesis (GO:0072088)3.18848504
95nucleoside diphosphate catabolic process (GO:0009134)3.18653763
96negative regulation of glycoprotein biosynthetic process (GO:0010561)3.18322651
97regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.17310571
98intestinal cholesterol absorption (GO:0030299)3.16700624
99hormone secretion (GO:0046879)3.16393480
100axoneme assembly (GO:0035082)3.14334784
101regulation of cilium movement (GO:0003352)3.13069014
102membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.12153742
103protein N-linked glycosylation (GO:0006487)3.10243287
104cytochrome complex assembly (GO:0017004)3.10067431
105cellular response to gonadotropin stimulus (GO:0071371)3.09722215
106Golgi organization (GO:0007030)3.09620573
107regulation of peptide transport (GO:0090087)3.09575371
108adaptation of signaling pathway (GO:0023058)3.08098579
109positive regulation of male gonad development (GO:2000020)3.07683847
110kynurenine metabolic process (GO:0070189)3.06318372
111positive regulation of receptor biosynthetic process (GO:0010870)3.04660466
112negative regulation of execution phase of apoptosis (GO:1900118)3.04195128
113protein complex biogenesis (GO:0070271)3.03773611
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03607491
115positive regulation of histone H3-K4 methylation (GO:0051571)3.03398959
116coronary vasculature morphogenesis (GO:0060977)3.00675152
117cellular response to glucagon stimulus (GO:0071377)3.00665862
118hormone transport (GO:0009914)3.00648189
119response to unfolded protein (GO:0006986)3.00185089
120epithelial cilium movement (GO:0003351)2.99626650
121response to topologically incorrect protein (GO:0035966)2.99427789
122negative regulation of insulin secretion (GO:0046676)2.99203709
123cellular response to vitamin (GO:0071295)2.96598185
124mannosylation (GO:0097502)2.95618069
125regulation of hexokinase activity (GO:1903299)2.95162841
126regulation of glucokinase activity (GO:0033131)2.95162841
127intestinal absorption (GO:0050892)2.95143911
128DNA deamination (GO:0045006)2.90977962
129drug transmembrane transport (GO:0006855)2.90815115
130protein targeting to Golgi (GO:0000042)2.90699691
131glucocorticoid biosynthetic process (GO:0006704)2.89268711
132positive regulation of gluconeogenesis (GO:0045722)2.89051919
133inositol phosphate catabolic process (GO:0071545)2.87992690
134response to misfolded protein (GO:0051788)2.86932336
135glycerophospholipid catabolic process (GO:0046475)2.86417101
136regulation of glucocorticoid secretion (GO:2000849)2.84626916
137cornea development in camera-type eye (GO:0061303)2.83891545
138androgen biosynthetic process (GO:0006702)2.83012773
139regulation of glucocorticoid metabolic process (GO:0031943)2.82075416
140parturition (GO:0007567)2.82030437
141regulation of calcium ion-dependent exocytosis (GO:0017158)2.81849574
142polyol catabolic process (GO:0046174)2.81626848
143mitochondrial respiratory chain complex assembly (GO:0033108)2.81377049
144Golgi vesicle transport (GO:0048193)2.81161987
145protein localization to Golgi apparatus (GO:0034067)2.80053863
146cellular response to ATP (GO:0071318)2.75882147
147multicellular organism reproduction (GO:0032504)2.75402302
148DNA methylation involved in gamete generation (GO:0043046)2.70786877
149protein K11-linked deubiquitination (GO:0035871)2.69037726
150negative regulation of telomere maintenance (GO:0032205)2.68378922
151sulfation (GO:0051923)2.65469666
152S-adenosylmethionine metabolic process (GO:0046500)2.65265644
153preassembly of GPI anchor in ER membrane (GO:0016254)2.64850805
154mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63631334
155mitochondrial respiratory chain complex I assembly (GO:0032981)2.63631334
156NADH dehydrogenase complex assembly (GO:0010257)2.63631334
157auditory receptor cell stereocilium organization (GO:0060088)2.63184593
158neuronal action potential (GO:0019228)2.62157308
159cilium morphogenesis (GO:0060271)2.60752310
160dopamine transport (GO:0015872)2.60546215
161inner ear receptor stereocilium organization (GO:0060122)2.59656525
162protein-cofactor linkage (GO:0018065)2.59113621
163response to follicle-stimulating hormone (GO:0032354)2.57475318
164phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56030488
165inositol phosphate dephosphorylation (GO:0046855)2.56030488
166tryptophan metabolic process (GO:0006568)2.55987207
167cellular biogenic amine catabolic process (GO:0042402)2.55266110
168amine catabolic process (GO:0009310)2.55266110
169regulation of female gonad development (GO:2000194)2.54196458
170cilium organization (GO:0044782)2.53664499
171kidney morphogenesis (GO:0060993)2.53408520
172protein localization to cilium (GO:0061512)2.53350627
173purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.51912411
1743-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.51912411
175regulation of meiosis I (GO:0060631)2.51353173
176gamma-aminobutyric acid transport (GO:0015812)2.51233204
177renal tubule morphogenesis (GO:0061333)2.51115696
178cilium assembly (GO:0042384)2.47419393
179indole-containing compound metabolic process (GO:0042430)2.46962144
180retinal cone cell development (GO:0046549)2.46881209
181G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45116865
182photoreceptor cell maintenance (GO:0045494)2.42231116
183negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.41728472
184aromatic amino acid family catabolic process (GO:0009074)2.41024958
185seminiferous tubule development (GO:0072520)2.40858984
186negative regulation of mast cell activation (GO:0033004)2.40536528
187behavioral response to ethanol (GO:0048149)2.40426882
188regulation of nuclear cell cycle DNA replication (GO:0033262)2.40216312
189regulation of action potential (GO:0098900)2.38079734
190reflex (GO:0060004)2.37943726
191peptidyl-histidine modification (GO:0018202)2.36341661
192photoreceptor cell development (GO:0042461)2.35396757
193regulation of rhodopsin mediated signaling pathway (GO:0022400)2.34931139
194neural tube formation (GO:0001841)2.33998525
195COPI coating of Golgi vesicle (GO:0048205)10.3269935
196Golgi transport vesicle coating (GO:0048200)10.3269935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.19635174
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.63301938
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.51863781
4GBX2_23144817_ChIP-Seq_PC3_Human3.23906859
5EZH2_22144423_ChIP-Seq_EOC_Human2.56064974
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55618632
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50267824
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.43981063
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.42970366
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.42437833
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36780419
12PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.33493512
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21999310
14FUS_26573619_Chip-Seq_HEK293_Human2.15998977
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14730819
16EWS_26573619_Chip-Seq_HEK293_Human2.06907150
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04554991
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01896792
19P300_19829295_ChIP-Seq_ESCs_Human2.01658955
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.01228397
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.9932998
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99609291
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98584600
24TAF15_26573619_Chip-Seq_HEK293_Human1.95188417
25TFEB_21752829_ChIP-Seq_HELA_Human1.94921934
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93111217
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90082358
28ER_23166858_ChIP-Seq_MCF-7_Human1.83988902
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80604479
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.78183905
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73721868
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.73594269
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.67602076
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65090562
35VDR_22108803_ChIP-Seq_LS180_Human1.63462305
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.61222522
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59861711
38FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.56882801
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56880105
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56713225
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55950845
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53220387
43CBP_20019798_ChIP-Seq_JUKART_Human1.53220387
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52868106
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.52482501
46SMAD4_21799915_ChIP-Seq_A2780_Human1.51868609
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51324434
48IGF1R_20145208_ChIP-Seq_DFB_Human1.50751363
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50557346
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50090900
51AR_25329375_ChIP-Seq_VCAP_Human1.49902319
52TCF4_23295773_ChIP-Seq_U87_Human1.44946561
53FOXA1_25552417_ChIP-Seq_VCAP_Human1.43597637
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43372303
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43236450
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41941238
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.41146094
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38861640
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38094758
60MYC_18940864_ChIP-ChIP_HL60_Human1.37801012
61TCF4_22108803_ChIP-Seq_LS180_Human1.37658716
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37315946
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.35939259
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.35658792
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35527401
66SOX2_19829295_ChIP-Seq_ESCs_Human1.35274738
67NANOG_19829295_ChIP-Seq_ESCs_Human1.35274738
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.35055729
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33887783
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.33181240
71GATA3_27048872_Chip-Seq_THYMUS_Human1.33111032
72GATA1_19941826_ChIP-Seq_K562_Human1.32327805
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30800646
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30800646
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30794652
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30428194
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29803703
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.29803703
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.29744742
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29628593
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29621132
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29508209
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28489646
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.28256249
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.26744513
86CLOCK_20551151_ChIP-Seq_293T_Human1.26283316
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25678876
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.25631707
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23365817
90RUNX2_22187159_ChIP-Seq_PCA_Human1.22633717
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22589970
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21532431
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20639344
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.19332903
95* RNF2_27304074_Chip-Seq_NSC_Mouse1.18756086
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18015656
97AR_20517297_ChIP-Seq_VCAP_Human1.17465482
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.17454204
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17123788
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16897142
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.16803920
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16090245
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15512091
104ZNF274_21170338_ChIP-Seq_K562_Hela1.14498471
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14126512
106NCOR_22424771_ChIP-Seq_293T_Human1.13847749
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13779468
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12537623
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12252261
110CDX2_22108803_ChIP-Seq_LS180_Human1.11728050
111GATA4_25053715_ChIP-Seq_YYC3_Human1.11121327
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10998795
113IRF1_19129219_ChIP-ChIP_H3396_Human1.10688002
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10430316
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09807732
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09206713
117P53_22387025_ChIP-Seq_ESCs_Mouse1.08047611
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.07967255
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.07839573
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.07835702
121HOXB7_26014856_ChIP-Seq_BT474_Human1.07597063
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.07450402
123IRF8_22096565_ChIP-ChIP_GC-B_Human1.07400392
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07085879
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06943772
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.06678220
127GATA6_25053715_ChIP-Seq_YYC3_Human1.06261896
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06165584
129GATA3_24758297_ChIP-Seq_MCF-7_Human1.05132193
130REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03206956
131HTT_18923047_ChIP-ChIP_STHdh_Human1.02340280
132CHD1_26751641_Chip-Seq_LNCaP_Human1.02301472
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01989321
134REST_21632747_ChIP-Seq_MESCs_Mouse1.01446254
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.00696017
136SOX2_20726797_ChIP-Seq_SW620_Human1.00262310
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99639044
138PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99489776
139STAT3_23295773_ChIP-Seq_U87_Human0.99094645
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98559705
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.98515225
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.97987336
143BCAT_22108803_ChIP-Seq_LS180_Human0.97927557
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97867286
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97677718
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95919957
147SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95565840
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95540910
149MYC_19829295_ChIP-Seq_ESCs_Human0.95143367
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94883787
151TP53_22573176_ChIP-Seq_HFKS_Human0.94204228
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93747376
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93692514
154PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93378323
155CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92798314
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92520714
157RXR_22158963_ChIP-Seq_LIVER_Mouse0.92470410
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91821604
159ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90924081
160FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90402293
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.89989770
162LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89579595
163ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89237653
164CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88684371
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.87526587
166NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86522824
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85270437
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85051104
169CREB1_26743006_Chip-Seq_LNCaP_Human0.83399962
170ISL1_27105846_Chip-Seq_CPCs_Mouse0.83200166
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.82075228
172AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81159908
173PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77045037
174GATA2_21666600_ChIP-Seq_HMVEC_Human0.76819160
175SPI1_23127762_ChIP-Seq_K562_Human0.76087624
176RARB_27405468_Chip-Seq_BRAIN_Mouse0.76029778
177GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75506674
178WT1_19549856_ChIP-ChIP_CCG9911_Human0.74735464
179GF1B_26923725_Chip-Seq_HPCs_Mouse0.74164463
180RUNX1_27514584_Chip-Seq_MCF-7_Human0.74025253
181KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72781085
182ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71589682
183AR_19668381_ChIP-Seq_PC3_Human0.70473938
184E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70345250
185STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.69006934
186WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67636895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.35619163
2MP0000013_abnormal_adipose_tissue4.57201908
3MP0002877_abnormal_melanocyte_morpholog4.39726844
4MP0002909_abnormal_adrenal_gland4.19690132
5MP0003283_abnormal_digestive_organ3.91439693
6MP0002693_abnormal_pancreas_physiology3.87059277
7MP0005379_endocrine/exocrine_gland_phen3.85246812
8MP0003183_abnormal_peptide_metabolism3.79530717
9MP0001944_abnormal_pancreas_morphology3.79214949
10MP0004043_abnormal_pH_regulation3.70355812
11MP0000678_abnormal_parathyroid_gland3.62153161
12MP0002837_dystrophic_cardiac_calcinosis3.23168557
13MP0009780_abnormal_chondrocyte_physiolo2.82363509
14MP0005220_abnormal_exocrine_pancreas2.65553790
15MP0000003_abnormal_adipose_tissue2.65220600
16MP0010386_abnormal_urinary_bladder2.60529239
17MP0005645_abnormal_hypothalamus_physiol2.54572729
18MP0008875_abnormal_xenobiotic_pharmacok2.52363862
19MP0005551_abnormal_eye_electrophysiolog2.37174133
20MP0003300_gastrointestinal_ulcer2.22171261
21MP0002078_abnormal_glucose_homeostasis2.21683061
22MP0008995_early_reproductive_senescence2.10525919
23MP0001986_abnormal_taste_sensitivity2.04806147
24MP0001765_abnormal_ion_homeostasis1.97548236
25MP0004264_abnormal_extraembryonic_tissu1.90028712
26MP0003172_abnormal_lysosome_physiology1.89665763
27MP0006054_spinal_hemorrhage1.81470627
28MP0006072_abnormal_retinal_apoptosis1.80552339
29MP0004885_abnormal_endolymph1.79952733
30MP0001968_abnormal_touch/_nociception1.76481207
31MP0002896_abnormal_bone_mineralization1.75810015
32MP0001756_abnormal_urination1.70084758
33MP0002876_abnormal_thyroid_physiology1.70057765
34MP0008961_abnormal_basal_metabolism1.68225598
35MP0006292_abnormal_olfactory_placode1.67874858
36MP0009046_muscle_twitch1.67298556
37MP0003122_maternal_imprinting1.66327305
38MP0002234_abnormal_pharynx_morphology1.65757540
39MP0004142_abnormal_muscle_tone1.65554659
40MP0003787_abnormal_imprinting1.63338412
41MP0003136_yellow_coat_color1.62443479
42MP0002102_abnormal_ear_morphology1.59755997
43MP0002928_abnormal_bile_duct1.58268716
44MP0003252_abnormal_bile_duct1.57927901
45MP0009379_abnormal_foot_pigmentation1.56576210
46MP0004133_heterotaxia1.56045189
47MP0009745_abnormal_behavioral_response1.55749282
48MP0001984_abnormal_olfaction1.55593943
49MP0008872_abnormal_physiological_respon1.52820439
50MP0010329_abnormal_lipoprotein_level1.51004438
51MP0003959_abnormal_lean_body1.49939218
52MP0000569_abnormal_digit_pigmentation1.49520846
53MP0009643_abnormal_urine_homeostasis1.47505419
54MP0000427_abnormal_hair_cycle1.44236132
55MP0002138_abnormal_hepatobiliary_system1.43556638
56MP0005389_reproductive_system_phenotype1.42740472
57MP0002163_abnormal_gland_morphology1.41979278
58MP0000372_irregular_coat_pigmentation1.41791812
59MP0002272_abnormal_nervous_system1.40443975
60MP0002638_abnormal_pupillary_reflex1.40006873
61MP0002160_abnormal_reproductive_system1.38738945
62MP0003011_delayed_dark_adaptation1.38713733
63MP0005058_abnormal_lysosome_morphology1.37137295
64MP0006276_abnormal_autonomic_nervous1.31551798
65MP0003880_abnormal_central_pattern1.31174410
66MP0002736_abnormal_nociception_after1.28032406
67MP0003953_abnormal_hormone_level1.27404969
68MP0000613_abnormal_salivary_gland1.24450249
69MP0004270_analgesia1.24282956
70MP0001501_abnormal_sleep_pattern1.23870330
71MP0001486_abnormal_startle_reflex1.22572340
72MP0003045_fibrosis1.22474366
73MP0002557_abnormal_social/conspecific_i1.20547218
74MP0005375_adipose_tissue_phenotype1.20480769
75MP0004742_abnormal_vestibular_system1.15269868
76MP0005636_abnormal_mineral_homeostasis1.14963955
77MP0003123_paternal_imprinting1.13989106
78MP0005365_abnormal_bile_salt1.12593851
79MP0003868_abnormal_feces_composition1.10704561
80MP0002168_other_aberrant_phenotype1.10246517
81MP0003890_abnormal_embryonic-extraembry1.09643657
82MP0001529_abnormal_vocalization1.07216060
83MP0003718_maternal_effect1.06350662
84MP0004147_increased_porphyrin_level1.05185588
85MP0005257_abnormal_intraocular_pressure1.04601743
86MP0003646_muscle_fatigue1.03205165
87MP0001905_abnormal_dopamine_level1.01967273
88MP0005410_abnormal_fertilization1.00642485
89MP0010234_abnormal_vibrissa_follicle1.00459413
90MP0002572_abnormal_emotion/affect_behav1.00416994
91MP0002254_reproductive_system_inflammat1.00132713
92MP0000631_abnormal_neuroendocrine_gland0.99854848
93MP0002277_abnormal_respiratory_mucosa0.99854657
94MP0001188_hyperpigmentation0.99470732
95MP0001929_abnormal_gametogenesis0.98929220
96MP0002653_abnormal_ependyma_morphology0.97894282
97MP0003121_genomic_imprinting0.97495468
98MP0003786_premature_aging0.96744191
99MP0002210_abnormal_sex_determination0.96705315
100MP0002064_seizures0.96497026
101MP0001324_abnormal_eye_pigmentation0.95424995
102MP0003567_abnormal_fetal_cardiomyocyte0.94306544
103MP0000647_abnormal_sebaceous_gland0.92797369
104MP0001970_abnormal_pain_threshold0.92644514
105MP0005195_abnormal_posterior_eye0.92562515
106MP0005085_abnormal_gallbladder_physiolo0.92520688
107MP0003698_abnormal_male_reproductive0.90792398
108MP0005386_behavior/neurological_phenoty0.89431221
109MP0004924_abnormal_behavior0.89431221
110MP0008789_abnormal_olfactory_epithelium0.89352432
111MP0002139_abnormal_hepatobiliary_system0.86116088
112MP0001764_abnormal_homeostasis0.85765216
113MP0005075_abnormal_melanosome_morpholog0.85370149
114MP0000653_abnormal_sex_gland0.85308314
115MP0001270_distended_abdomen0.85144281
116MP0005084_abnormal_gallbladder_morpholo0.83993778
117MP0000383_abnormal_hair_follicle0.82462231
118MP0003119_abnormal_digestive_system0.81957394
119MP0000230_abnormal_systemic_arterial0.81904723
120MP0005310_abnormal_salivary_gland0.81448716
121MP0005076_abnormal_cell_differentiation0.78464388
122MP0005535_abnormal_body_temperature0.78133602
123MP0001299_abnormal_eye_distance/0.77996022
124MP0003879_abnormal_hair_cell0.76322790
125MP0000462_abnormal_digestive_system0.74612589
126MP0002938_white_spotting0.73423887
127MP0000681_abnormal_thyroid_gland0.73252226
128MP0001666_abnormal_nutrient_absorption0.72624785
129MP0005448_abnormal_energy_balance0.71972587
130MP0002751_abnormal_autonomic_nervous0.66325857
131MP0004145_abnormal_muscle_electrophysio0.65386609
132MP0000639_abnormal_adrenal_gland0.64252452
133MP0002177_abnormal_outer_ear0.63494806
134MP0005332_abnormal_amino_acid0.62662128
135MP0009703_decreased_birth_body0.59492925
136MP0009672_abnormal_birth_weight0.59215185
137MP0005646_abnormal_pituitary_gland0.55450087
138MP0005174_abnormal_tail_pigmentation0.55189033
139MP0004019_abnormal_vitamin_homeostasis0.55030898
140MP0005452_abnormal_adipose_tissue0.54489397
141MP0005408_hypopigmentation0.53370721
142MP0005187_abnormal_penis_morphology0.53207688
143MP0000538_abnormal_urinary_bladder0.51658426
144MP0000428_abnormal_craniofacial_morphol0.50407975
145MP0009642_abnormal_blood_homeostasis0.48017800
146MP0003795_abnormal_bone_structure0.47948813
147MP0008877_abnormal_DNA_methylation0.47167108
148MP0005253_abnormal_eye_physiology0.46204178
149MP0002733_abnormal_thermal_nociception0.45523690
150MP0002734_abnormal_mechanical_nocicepti0.44753276
151MP0003866_abnormal_defecation0.44153868
152MP0002136_abnormal_kidney_physiology0.43672159
153MP0001919_abnormal_reproductive_system0.43415557
154MP0000015_abnormal_ear_pigmentation0.43244826
155MP0001502_abnormal_circadian_rhythm0.41841305
156MP0001348_abnormal_lacrimal_gland0.41314706
157MP0005083_abnormal_biliary_tract0.41275676
158MP0001485_abnormal_pinna_reflex0.40736591

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.07748292
2Hypoglycemic seizures (HP:0002173)7.16702629
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.05247670
4Symptomatic seizures (HP:0011145)6.27923826
5Hypoglycemic coma (HP:0001325)6.26777960
6Hyperglycemia (HP:0003074)5.85420277
7Pancreatic islet-cell hyperplasia (HP:0004510)5.60155679
8Abnormality of endocrine pancreas physiology (HP:0012093)5.16047850
9Abnormality of the pancreatic islet cells (HP:0006476)5.16047850
10Abnormality of calcium-phosphate metabolism (HP:0100530)4.96642589
11Insulin-resistant diabetes mellitus (HP:0000831)4.95096325
12Ketoacidosis (HP:0001993)4.78049073
13Large for gestational age (HP:0001520)4.67457208
14Late onset (HP:0003584)4.38271195
15Unilateral renal agenesis (HP:0000122)4.28148891
16Molar tooth sign on MRI (HP:0002419)4.03040037
17Abnormality of midbrain morphology (HP:0002418)4.03040037
18True hermaphroditism (HP:0010459)3.98250779
19Pancreatic cysts (HP:0001737)3.79721182
20Hyperphosphatemia (HP:0002905)3.67083028
21Hyperparathyroidism (HP:0000843)3.64326209
22Retinal atrophy (HP:0001105)3.56685900
23Decreased circulating renin level (HP:0003351)3.51691849
24Pancreatic fibrosis (HP:0100732)3.48001197
25Agitation (HP:0000713)3.47037368
26Dysostosis multiplex (HP:0000943)3.36435514
27Prominent metopic ridge (HP:0005487)3.35309731
28Congenital stationary night blindness (HP:0007642)3.34822966
29Nephronophthisis (HP:0000090)3.33564273
30Type II lissencephaly (HP:0007260)3.28151081
31Hypokalemia (HP:0002900)3.27503798
32Abnormality of the renal cortex (HP:0011035)3.26786530
33Urinary glycosaminoglycan excretion (HP:0003541)3.21381111
34Mucopolysacchariduria (HP:0008155)3.21381111
35Missing ribs (HP:0000921)3.12120306
36Chronic hepatic failure (HP:0100626)3.10059173
37Abnormal pancreas size (HP:0012094)3.00112257
38Attenuation of retinal blood vessels (HP:0007843)2.99431680
39Insulin resistance (HP:0000855)2.97110924
40Abnormality of renin-angiotensin system (HP:0000847)2.91420354
41Male pseudohermaphroditism (HP:0000037)2.90466105
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90126127
43Abnormality of polysaccharide metabolism (HP:0011012)2.90126127
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90126127
4511 pairs of ribs (HP:0000878)2.88345235
46Abnormality of the renal medulla (HP:0100957)2.88227080
47Mesangial abnormality (HP:0001966)2.88126415
48Increased circulating renin level (HP:0000848)2.87171504
49Abnormality of the metopic suture (HP:0005556)2.85235635
50Abnormality of potassium homeostasis (HP:0011042)2.85227488
51Medial flaring of the eyebrow (HP:0010747)2.84933013
52Hyperkalemia (HP:0002153)2.83842022
53Renal cortical cysts (HP:0000803)2.82474393
54Hyperventilation (HP:0002883)2.77265610
55Intestinal atresia (HP:0011100)2.76026114
56Tubular atrophy (HP:0000092)2.74081540
57Abnormal rod and cone electroretinograms (HP:0008323)2.71605674
58Hypotension (HP:0002615)2.70467105
59Hyperactive renin-angiotensin system (HP:0000841)2.67123356
60Gonadal dysgenesis (HP:0000133)2.66358646
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65499294
62Abnormality of alanine metabolism (HP:0010916)2.65499294
63Hyperalaninemia (HP:0003348)2.65499294
64Ketosis (HP:0001946)2.65426741
65Papilledema (HP:0001085)2.64332682
66Dysautonomia (HP:0002459)2.60585547
67Abnormality of chloride homeostasis (HP:0011422)2.55976433
68Hypothermia (HP:0002045)2.53769753
69Aplasia/hypoplasia of the uterus (HP:0008684)2.50945771
70Macroorchidism (HP:0000053)2.50885092
71Methylmalonic acidemia (HP:0002912)2.49626256
72Hypoplasia of the uterus (HP:0000013)2.43539792
73Hypsarrhythmia (HP:0002521)2.41546367
74EEG with generalized epileptiform discharges (HP:0011198)2.39125534
75Osteomalacia (HP:0002749)2.37108884
76Generalized aminoaciduria (HP:0002909)2.35630650
77Hypoplastic labia majora (HP:0000059)2.34936062
78Conjugated hyperbilirubinemia (HP:0002908)2.30662005
79Abolished electroretinogram (ERG) (HP:0000550)2.30405055
80Cerebellar dysplasia (HP:0007033)2.27950176
81Epileptiform EEG discharges (HP:0011182)2.26763394
82Abnormality of the intrinsic pathway (HP:0010989)2.26538811
83Pendular nystagmus (HP:0012043)2.21435758
84Hypercortisolism (HP:0001578)2.20274858
85Abnormality of magnesium homeostasis (HP:0004921)2.17380463
86Lissencephaly (HP:0001339)2.16211717
87Congenital sensorineural hearing impairment (HP:0008527)2.15447574
88Inability to walk (HP:0002540)2.14981693
89Metaphyseal cupping (HP:0003021)2.14664974
90Bony spicule pigmentary retinopathy (HP:0007737)2.14490318
91Gout (HP:0001997)2.13294303
92Gaze-evoked nystagmus (HP:0000640)2.12934079
93Polyuria (HP:0000103)2.12542535
94Increased CSF lactate (HP:0002490)2.11628546
95Gait imbalance (HP:0002141)2.09978331
96Congenital glaucoma (HP:0001087)2.09783844
97Progressive inability to walk (HP:0002505)2.08281987
98Cystic liver disease (HP:0006706)2.07843920
99Abnormality of the labia majora (HP:0012881)2.07075436
100Congenital primary aphakia (HP:0007707)2.06624350
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06163150
102Exocrine pancreatic insufficiency (HP:0001738)2.05388841
103Hypophosphatemia (HP:0002148)2.05243261
104Abnormal biliary tract physiology (HP:0012439)2.03049369
105Bile duct proliferation (HP:0001408)2.03049369
106Retinal dysplasia (HP:0007973)2.03018748
107Testicular neoplasm (HP:0010788)2.02610336
108Mitochondrial inheritance (HP:0001427)2.02143070
109Optic nerve hypoplasia (HP:0000609)2.00647461
110Restlessness (HP:0000711)2.00627923
111Sclerocornea (HP:0000647)2.00146622
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.96584735
113Acute necrotizing encephalopathy (HP:0006965)1.94996063
114Decreased central vision (HP:0007663)1.94773167
115Abnormality of vitamin B metabolism (HP:0004340)1.93756968
116Methylmalonic aciduria (HP:0012120)1.93309418
117Severe muscular hypotonia (HP:0006829)1.93092118
118Hypokalemic alkalosis (HP:0001949)1.92833242
119Abnormality of the labia minora (HP:0012880)1.92655833
120Lipid accumulation in hepatocytes (HP:0006561)1.92596442
121Renal salt wasting (HP:0000127)1.92524769
1223-Methylglutaconic aciduria (HP:0003535)1.92416702
123Genital tract atresia (HP:0001827)1.92116785
124Sex reversal (HP:0012245)1.92091199
125Abnormal sex determination (HP:0012244)1.92091199
126Tetany (HP:0001281)1.92024058
127Progressive macrocephaly (HP:0004481)1.91716729
128Orthostatic hypotension (HP:0001278)1.89783903
129Abnormal biliary tract morphology (HP:0012440)1.89670363
130Hemiparesis (HP:0001269)1.88539137
131Abnormality of urine glucose concentration (HP:0011016)1.87782397
132Glycosuria (HP:0003076)1.87782397
133Adrenal overactivity (HP:0002717)1.87704335
134Hyperphosphaturia (HP:0003109)1.87271356
135Abdominal distention (HP:0003270)1.86771579
136Hyperglycinemia (HP:0002154)1.86735112
137Nephrogenic diabetes insipidus (HP:0009806)1.86124625
138Anencephaly (HP:0002323)1.85090497
139Abnormal urine output (HP:0012590)1.83930875
140Increased hepatocellular lipid droplets (HP:0006565)1.83708757
141Hypoplasia of the pons (HP:0012110)1.83116205
142Abnormality of the pons (HP:0007361)1.83116147
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.82275434
144Hepatic necrosis (HP:0002605)1.81905163
145Acute encephalopathy (HP:0006846)1.81728313
146Progressive neurologic deterioration (HP:0002344)1.81232837
147Broad-based gait (HP:0002136)1.81147842
148Vaginal atresia (HP:0000148)1.80720579
149Congenital hepatic fibrosis (HP:0002612)1.80619084
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80535157
151Labial hypoplasia (HP:0000066)1.79940797
152Female pseudohermaphroditism (HP:0010458)1.79483234
153Increased CSF protein (HP:0002922)1.77431342
154Oligodactyly (hands) (HP:0001180)1.77049910
155Menstrual irregularities (HP:0000858)1.76817829
156Absent speech (HP:0001344)1.76523738
157Gastrointestinal atresia (HP:0002589)1.75283825
158Postaxial foot polydactyly (HP:0001830)1.75196312
159Pachygyria (HP:0001302)1.74510025
160Furrowed tongue (HP:0000221)1.73897406
161Limb hypertonia (HP:0002509)1.73425851
162Disproportionate short-trunk short stature (HP:0003521)1.73365248
163Keratoconus (HP:0000563)1.71635327
164Increased corneal curvature (HP:0100692)1.71635327
165Thin bony cortex (HP:0002753)1.71235464
166Chronic bronchitis (HP:0004469)1.71141312
167Thoracolumbar scoliosis (HP:0002944)1.70958189
168Hypocalcemia (HP:0002901)1.70404203
169Severe short stature (HP:0003510)1.67997394
170Abnormal drinking behavior (HP:0030082)1.67331009
171Polydipsia (HP:0001959)1.67331009
172Growth hormone excess (HP:0000845)1.64986602
173Tachypnea (HP:0002789)1.63618753
174Hypercalciuria (HP:0002150)1.63030405
175Visual hallucinations (HP:0002367)1.62665529
176Skin nodule (HP:0200036)1.62279777
177Cortical visual impairment (HP:0100704)1.61375250
178Pheochromocytoma (HP:0002666)1.60679801
179Hypomagnesemia (HP:0002917)1.60372421
180Turricephaly (HP:0000262)1.59752101
181Anteriorly placed anus (HP:0001545)1.55781850
182Hyperaldosteronism (HP:0000859)1.55133811
183Aplasia/Hypoplasia of the fovea (HP:0008060)1.54777804
184Hypoplasia of the fovea (HP:0007750)1.54777804
185Generalized hyperpigmentation (HP:0007440)1.54290482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.48229263
2INSRR5.39060287
3MAPK154.73820935
4TAOK34.22969102
5PASK3.60086464
6WNK43.44200977
7MAP3K23.32982351
8FRK3.16287715
9PIK3CG3.07047655
10MAP4K23.05671244
11ADRBK22.88214989
12PINK12.87331063
13ZAK2.57007640
14HIPK22.54633988
15PRKD32.44593213
16BMPR1B2.39476556
17GRK12.37720713
18SCYL22.10799155
19UHMK12.09936199
20CASK2.08256970
21ACVR1B2.04877115
22STK391.90706429
23MAP3K11.81401472
24TLK11.80113540
25OXSR11.78501919
26EPHA31.71545972
27IRAK31.67880853
28MAP3K31.66404363
29MAPK131.66381814
30MAP3K41.53930621
31TRIB31.51320956
32DAPK21.49541795
33DYRK1B1.46433969
34WNK11.38304733
35FGFR21.38113781
36ERN11.37605103
37PTK61.31718602
38MKNK21.31619360
39CSNK1G11.30885479
40CAMKK21.29531499
41PAK31.27851871
42BRSK21.26380613
43CDC42BPA1.23489531
44TRIM281.19834303
45TXK1.16794572
46PDGFRA1.14570646
47TNIK1.13802047
48EPHA21.12806930
49STK161.12267313
50MST41.12102268
51PNCK1.10272022
52PRKCH1.09903706
53FLT31.07869894
54CSNK1G31.07843628
55PHKG21.06076835
56PHKG11.06076835
57CSNK1G21.04905809
58ADRBK10.99288085
59BCKDK0.96506694
60NTRK30.94780620
61PRKD20.94329039
62PTK20.94008869
63PRKCG0.91970337
64BRD40.91252144
65MAP2K60.91109440
66FGFR40.86074239
67DYRK20.85245740
68IRAK10.83444877
69CSNK1A1L0.78758819
70PLK20.77372821
71EPHB10.77037974
72NTRK10.73005552
73PRKAA10.72621890
74WEE10.72283514
75JAK20.72130792
76MUSK0.71000902
77PLK30.70866781
78STK38L0.70182596
79MAP2K70.69350851
80MKNK10.69284032
81FER0.68803798
82TESK10.66442950
83NLK0.66272550
84PDK20.65128259
85MAP2K20.64875585
86AKT30.64581624
87MTOR0.63334066
88KSR20.62374259
89RET0.61837539
90MARK10.61602953
91STK30.61260371
92STK110.59134411
93EPHA40.58656382
94PLK40.58010392
95ERBB30.57440857
96TIE10.55806278
97JAK10.54128023
98FGFR30.53674387
99VRK10.53306041
100IKBKB0.52718674
101PRKCQ0.50397158
102EIF2AK30.50000860
103PTK2B0.49847839
104PRKACA0.48123104
105CAMK10.47684328
106NUAK10.47600532
107PRKCZ0.46764508
108CSNK1D0.46470009
109TNK20.46434548
110BCR0.45807437
111TGFBR10.44531751
112CAMK2A0.44319005
113ALK0.44258653
114NTRK20.43845478
115TAF10.43529920
116PKN20.42117859
117PLK10.41992535
118TSSK60.41871889
119ERBB20.40837383
120CDK120.40509870
121MAPKAPK50.40426438
122PIK3CA0.39458198
123CHUK0.39342802
124MAP3K120.39229424
125GSK3A0.38501965
126MET0.38080475
127RIPK10.35290708
128PRKG10.34889102
129ITK0.34823882
130PRKCI0.34740285
131BRSK10.33906746
132CSNK1E0.33130608
133PRKD10.32200731
134IRAK40.32074235
135PRKCA0.31809879
136SIK10.31323020
137SGK20.30781880
138ATM0.30667871
139PRKDC0.30244186
140NEK20.30225139
141DYRK1A0.29957630
142SGK30.29312834
143TAOK10.28802807
144CAMK2D0.28657079
145CAMKK10.28543120
146PRKCE0.27793723
147IGF1R0.26821896
148LATS10.26457433
149SGK2230.25712311
150SGK4940.25712311
151PRKACG0.25403598
152RPS6KB10.25127804
153CSK0.24877320
154MAPK140.24674273
155MAPK100.24445643
156BMPR20.24380144
157PDGFRB0.24175000
158AKT10.23528419
159CAMK1G0.23506316
160CAMK1D0.20996481
161RPS6KA30.19833988
162PRKAA20.19825572
163EGFR0.19436073
164MAP2K30.18880898
165SGK10.18208560
166CSNK1A10.17804525
167GSK3B0.17606989
168ZAP700.17504480
169MAP3K100.17328458
170BRAF0.17204036
171RPS6KA50.15212819

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.53327728
2Protein export_Homo sapiens_hsa030604.44727727
3Insulin secretion_Homo sapiens_hsa049113.56528976
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.14680827
5Type I diabetes mellitus_Homo sapiens_hsa049402.97909967
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80952775
7Type II diabetes mellitus_Homo sapiens_hsa049302.70707317
8Sulfur metabolism_Homo sapiens_hsa009202.62138101
9Phototransduction_Homo sapiens_hsa047442.43578051
10Caffeine metabolism_Homo sapiens_hsa002322.23272740
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96020663
12Oxidative phosphorylation_Homo sapiens_hsa001901.95008914
13Nitrogen metabolism_Homo sapiens_hsa009101.91741239
14Ether lipid metabolism_Homo sapiens_hsa005651.90994960
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.81441443
16Propanoate metabolism_Homo sapiens_hsa006401.72112959
17Lysosome_Homo sapiens_hsa041421.70222957
18Vibrio cholerae infection_Homo sapiens_hsa051101.64575811
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.64320526
20Basal transcription factors_Homo sapiens_hsa030221.62914785
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61019525
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59342298
23Other glycan degradation_Homo sapiens_hsa005111.57383841
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55804776
25Cocaine addiction_Homo sapiens_hsa050301.55586117
26N-Glycan biosynthesis_Homo sapiens_hsa005101.54062539
27Nicotine addiction_Homo sapiens_hsa050331.54059545
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48797693
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44501655
30ABC transporters_Homo sapiens_hsa020101.42948171
31Pancreatic secretion_Homo sapiens_hsa049721.41015328
32Selenocompound metabolism_Homo sapiens_hsa004501.38362865
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37675339
34Homologous recombination_Homo sapiens_hsa034401.37011206
35Parkinsons disease_Homo sapiens_hsa050121.36269299
36Fanconi anemia pathway_Homo sapiens_hsa034601.34809787
37Steroid biosynthesis_Homo sapiens_hsa001001.33263799
38Peroxisome_Homo sapiens_hsa041461.32737866
39Glucagon signaling pathway_Homo sapiens_hsa049221.30061772
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27534915
41RNA polymerase_Homo sapiens_hsa030201.27218458
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23525901
43Chemical carcinogenesis_Homo sapiens_hsa052041.22799809
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.20783975
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19561590
46One carbon pool by folate_Homo sapiens_hsa006701.13891729
47Thyroid hormone synthesis_Homo sapiens_hsa049181.08800056
48Insulin resistance_Homo sapiens_hsa049311.08590130
49Vitamin B6 metabolism_Homo sapiens_hsa007501.08256701
50Amphetamine addiction_Homo sapiens_hsa050311.08252978
51RNA degradation_Homo sapiens_hsa030181.06446834
52beta-Alanine metabolism_Homo sapiens_hsa004101.01452673
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00854848
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00100356
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98786077
56Circadian rhythm_Homo sapiens_hsa047100.97159442
57Vitamin digestion and absorption_Homo sapiens_hsa049770.96246860
58Retinol metabolism_Homo sapiens_hsa008300.92879526
59Fatty acid degradation_Homo sapiens_hsa000710.91544787
60Olfactory transduction_Homo sapiens_hsa047400.91264230
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87928273
62Arachidonic acid metabolism_Homo sapiens_hsa005900.87014938
63Fatty acid elongation_Homo sapiens_hsa000620.86421314
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86315939
65Prolactin signaling pathway_Homo sapiens_hsa049170.85432281
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84269828
67Huntingtons disease_Homo sapiens_hsa050160.84160031
68Estrogen signaling pathway_Homo sapiens_hsa049150.83236148
69Prion diseases_Homo sapiens_hsa050200.82844331
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79905678
71Taste transduction_Homo sapiens_hsa047420.77010145
72Folate biosynthesis_Homo sapiens_hsa007900.76365679
73Dopaminergic synapse_Homo sapiens_hsa047280.76074300
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76042669
75Metabolic pathways_Homo sapiens_hsa011000.75189245
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74732457
77Alzheimers disease_Homo sapiens_hsa050100.73620452
78Regulation of autophagy_Homo sapiens_hsa041400.72702642
79mTOR signaling pathway_Homo sapiens_hsa041500.72697940
80Dorso-ventral axis formation_Homo sapiens_hsa043200.71157693
81Renin secretion_Homo sapiens_hsa049240.70862236
82Fatty acid metabolism_Homo sapiens_hsa012120.70300880
83Cardiac muscle contraction_Homo sapiens_hsa042600.69861371
84Histidine metabolism_Homo sapiens_hsa003400.69065419
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.68739812
86Cholinergic synapse_Homo sapiens_hsa047250.67858404
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66429051
88Protein digestion and absorption_Homo sapiens_hsa049740.63682097
89Salivary secretion_Homo sapiens_hsa049700.63389470
90Insulin signaling pathway_Homo sapiens_hsa049100.63233743
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63031472
92Purine metabolism_Homo sapiens_hsa002300.62543304
93Glutamatergic synapse_Homo sapiens_hsa047240.62514210
94Tryptophan metabolism_Homo sapiens_hsa003800.61649497
95Glycerolipid metabolism_Homo sapiens_hsa005610.61094546
96Mineral absorption_Homo sapiens_hsa049780.60918844
97Lysine degradation_Homo sapiens_hsa003100.59870509
98Long-term potentiation_Homo sapiens_hsa047200.59609434
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59324781
100Linoleic acid metabolism_Homo sapiens_hsa005910.58365350
101Synaptic vesicle cycle_Homo sapiens_hsa047210.57875663
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57074174
103Serotonergic synapse_Homo sapiens_hsa047260.56052972
104Starch and sucrose metabolism_Homo sapiens_hsa005000.53735463
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53410284
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53345254
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53069231
108Fat digestion and absorption_Homo sapiens_hsa049750.52972908
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51966055
110Alcoholism_Homo sapiens_hsa050340.51859519
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50869819
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50751457
113Antigen processing and presentation_Homo sapiens_hsa046120.50305057
114Circadian entrainment_Homo sapiens_hsa047130.48784524
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48550671
116Sphingolipid metabolism_Homo sapiens_hsa006000.47169549
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47132757
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47009441
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46597469
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45880807
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.45729694
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45557632
123Galactose metabolism_Homo sapiens_hsa000520.43420633
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43109101
125Hedgehog signaling pathway_Homo sapiens_hsa043400.41798066
126Bladder cancer_Homo sapiens_hsa052190.41624435
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41015794
128Calcium signaling pathway_Homo sapiens_hsa040200.40372055
129GABAergic synapse_Homo sapiens_hsa047270.39579333
130cAMP signaling pathway_Homo sapiens_hsa040240.39024355
131Long-term depression_Homo sapiens_hsa047300.38581628
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37991776
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.37910824
134Thyroid cancer_Homo sapiens_hsa052160.37354559
135Gap junction_Homo sapiens_hsa045400.37251563
136Arginine and proline metabolism_Homo sapiens_hsa003300.37229883
137Collecting duct acid secretion_Homo sapiens_hsa049660.37089392
138Renal cell carcinoma_Homo sapiens_hsa052110.36874641
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36159649
140Melanogenesis_Homo sapiens_hsa049160.34931622
141AMPK signaling pathway_Homo sapiens_hsa041520.34332063
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33726846
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33205972
144GnRH signaling pathway_Homo sapiens_hsa049120.32392004
145Pyruvate metabolism_Homo sapiens_hsa006200.31684671
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30328781
147Butanoate metabolism_Homo sapiens_hsa006500.30221286
148Glutathione metabolism_Homo sapiens_hsa004800.30162231
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.30029485
150Gastric acid secretion_Homo sapiens_hsa049710.29615060
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28512997
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27131800
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25146058
154Adherens junction_Homo sapiens_hsa045200.23303074
155Prostate cancer_Homo sapiens_hsa052150.23247248
156FoxO signaling pathway_Homo sapiens_hsa040680.22870379
157Endometrial cancer_Homo sapiens_hsa052130.20466801
158Morphine addiction_Homo sapiens_hsa050320.19926618
159Fructose and mannose metabolism_Homo sapiens_hsa000510.19643764
160Renin-angiotensin system_Homo sapiens_hsa046140.19172212
161Endocytosis_Homo sapiens_hsa041440.17707263
162Wnt signaling pathway_Homo sapiens_hsa043100.16880792
163Amoebiasis_Homo sapiens_hsa051460.16527310
164Chronic myeloid leukemia_Homo sapiens_hsa052200.15513357
165Ovarian steroidogenesis_Homo sapiens_hsa049130.14835267

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