MAP3K12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)8.86735528
2adenosine receptor signaling pathway (GO:0001973)6.36987751
3negative regulation of cell aging (GO:0090344)6.22814763
4urinary tract smooth muscle contraction (GO:0014848)6.19497370
5positive regulation of protein kinase C signaling (GO:0090037)5.81492941
6meiotic chromosome segregation (GO:0045132)5.78185930
7regulation of skeletal muscle contraction (GO:0014819)5.61431051
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55674327
9GDP-mannose metabolic process (GO:0019673)5.55234928
10behavioral response to nicotine (GO:0035095)5.27720908
11purinergic nucleotide receptor signaling pathway (GO:0035590)5.22587419
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.04562423
13adenine nucleotide transport (GO:0051503)5.03745943
14synaptic vesicle maturation (GO:0016188)4.99533945
15lens fiber cell differentiation (GO:0070306)4.90727823
16vocalization behavior (GO:0071625)4.89200095
17locomotory exploration behavior (GO:0035641)4.83922084
18sensory perception of taste (GO:0050909)4.81993306
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.81128076
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74344679
21response to ATP (GO:0033198)4.60654990
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58982666
23synaptic vesicle exocytosis (GO:0016079)4.56389770
24peristalsis (GO:0030432)4.54567342
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.52250133
26rRNA methylation (GO:0031167)4.49714557
27regulation of protein kinase A signaling (GO:0010738)4.39085831
28synaptic vesicle endocytosis (GO:0048488)4.36240526
29purine ribonucleotide transport (GO:0015868)4.32884591
30glutamate secretion (GO:0014047)4.32772921
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.24462078
32regulation of synaptic vesicle exocytosis (GO:2000300)4.22559354
33synaptic vesicle docking involved in exocytosis (GO:0016081)4.21108251
34regulation of glutamate receptor signaling pathway (GO:1900449)4.16968752
35protein localization to synapse (GO:0035418)4.09578849
36nucleotide transmembrane transport (GO:1901679)4.05687220
37regulation of neuronal synaptic plasticity (GO:0048168)4.04138080
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.02622552
39purinergic receptor signaling pathway (GO:0035587)3.96842737
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94632751
41sex determination (GO:0007530)3.93415879
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.93347725
43synaptic transmission, glutamatergic (GO:0035249)3.89463231
44neuron cell-cell adhesion (GO:0007158)3.88530216
45melanin biosynthetic process (GO:0042438)3.87695204
46glutamate receptor signaling pathway (GO:0007215)3.84722680
47regulation of synaptic vesicle transport (GO:1902803)3.81833511
48nucleoside transmembrane transport (GO:1901642)3.81241788
49purine nucleotide transport (GO:0015865)3.75176206
50exploration behavior (GO:0035640)3.68257030
51neurotransmitter secretion (GO:0007269)3.68217745
52cell migration in hindbrain (GO:0021535)3.65707799
533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.63856773
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.63856773
55UV protection (GO:0009650)3.63788504
56response to pheromone (GO:0019236)3.61931769
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61906752
58neurotransmitter-gated ion channel clustering (GO:0072578)3.58634917
59mannose metabolic process (GO:0006013)3.58599667
60dendritic spine morphogenesis (GO:0060997)3.57691503
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57064797
62melanin metabolic process (GO:0006582)3.55981001
63neuronal action potential propagation (GO:0019227)3.55942758
64regulation of respiratory system process (GO:0044065)3.54574111
65gamma-aminobutyric acid transport (GO:0015812)3.53952647
66rRNA modification (GO:0000154)3.53470746
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52511928
68positive regulation of catecholamine secretion (GO:0033605)3.50883922
69neuron-neuron synaptic transmission (GO:0007270)3.49550931
70long-term memory (GO:0007616)3.48270100
71cerebellar Purkinje cell differentiation (GO:0021702)3.42736893
72regulation of postsynaptic membrane potential (GO:0060078)3.41031848
73sialylation (GO:0097503)3.40572406
74positive regulation of synapse maturation (GO:0090129)3.40203006
75response to gravity (GO:0009629)3.38526613
76detection of light stimulus involved in sensory perception (GO:0050962)3.35616155
77detection of light stimulus involved in visual perception (GO:0050908)3.35616155
78neuromuscular process controlling posture (GO:0050884)3.35080530
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34570472
80neuromuscular process controlling balance (GO:0050885)3.34272477
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34143322
82secondary metabolite biosynthetic process (GO:0044550)3.33194062
83layer formation in cerebral cortex (GO:0021819)3.32962643
84regulation of synapse structural plasticity (GO:0051823)3.30424510
85postsynaptic membrane organization (GO:0001941)3.29976039
86mitotic cell cycle arrest (GO:0071850)3.28700114
87regulation of respiratory gaseous exchange (GO:0043576)3.27797845
88gonadal mesoderm development (GO:0007506)3.27586934
89regulation of neurotransmitter secretion (GO:0046928)3.24904863
90regulation of synapse maturation (GO:0090128)3.23705196
91dendrite morphogenesis (GO:0048813)3.20874137
92positive regulation of membrane potential (GO:0045838)3.20248612
93proline transport (GO:0015824)3.19557806
94regulation of dendritic spine morphogenesis (GO:0061001)3.19003055
95regulation of cAMP-dependent protein kinase activity (GO:2000479)3.18191246
96transmission of nerve impulse (GO:0019226)3.15963058
97regulation of cytokine production involved in inflammatory response (GO:1900015)3.14587228
98central nervous system projection neuron axonogenesis (GO:0021952)3.13432722
99positive regulation of CREB transcription factor activity (GO:0032793)3.12658081
100protein import into peroxisome matrix (GO:0016558)3.11298268
101activation of adenylate cyclase activity (GO:0007190)3.10715290
102regulation of synaptic plasticity (GO:0048167)3.08274551
103cellular potassium ion homeostasis (GO:0030007)3.07215136
104DNA strand renaturation (GO:0000733)3.05636948
105behavioral response to pain (GO:0048266)3.05392765
106auditory behavior (GO:0031223)3.04952525
107axonal fasciculation (GO:0007413)3.04913019
108innervation (GO:0060384)3.01793107
109neuron recognition (GO:0008038)3.00131208
110protein carboxylation (GO:0018214)3.00069304
111peptidyl-glutamic acid carboxylation (GO:0017187)3.00069304
112negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.99160210
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.98428116
114neurotransmitter transport (GO:0006836)2.97863511
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.94189820
116neuromuscular process (GO:0050905)2.94044320
117glycine transport (GO:0015816)2.93728725
118regulation of cell aging (GO:0090342)2.93432437
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93246818
120response to auditory stimulus (GO:0010996)2.93135894
121cerebellar granule cell differentiation (GO:0021707)2.92587066
122learning (GO:0007612)2.91977691
123negative regulation of Rho protein signal transduction (GO:0035024)2.91014499
124positive regulation of adenylate cyclase activity (GO:0045762)2.90930087
125regulation of neurotransmitter transport (GO:0051588)2.90843189
126positive regulation of dendritic spine development (GO:0060999)2.90735334
127phosphatidylglycerol biosynthetic process (GO:0006655)2.90465809
128positive regulation of heat generation (GO:0031652)2.90182427
129G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.90009592
130membrane depolarization (GO:0051899)2.88435081
131regulation of protein kinase C signaling (GO:0090036)2.85476449
132synapse assembly (GO:0007416)2.85058633
133membrane depolarization during action potential (GO:0086010)2.82269907
134positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80635100
135transepithelial transport (GO:0070633)2.80588938
136presynaptic membrane assembly (GO:0097105)2.79955369
137long-term synaptic potentiation (GO:0060291)2.79779843
138regulation of synaptic transmission, glutamatergic (GO:0051966)2.79673750
139membrane hyperpolarization (GO:0060081)2.79299537
140semaphorin-plexin signaling pathway (GO:0071526)2.77159202
141neuronal ion channel clustering (GO:0045161)2.76757505
142replication fork processing (GO:0031297)2.76697075
143positive regulation of neurotransmitter secretion (GO:0001956)2.75087292
144regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74075168
145dendritic spine organization (GO:0097061)2.73447850
146axon ensheathment in central nervous system (GO:0032291)2.73020179
147central nervous system myelination (GO:0022010)2.73020179
148regulation of vesicle fusion (GO:0031338)2.72758884
149cell communication by electrical coupling (GO:0010644)2.72006313
150cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71180758
151neuromuscular synaptic transmission (GO:0007274)2.71010789
152righting reflex (GO:0060013)2.70696414
153positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67970265
154synaptic transmission, cholinergic (GO:0007271)2.67731935
155negative regulation of dendrite development (GO:2000171)2.66682044
156positive regulation of cyclase activity (GO:0031281)2.66082395
157regulation of synaptic transmission, GABAergic (GO:0032228)2.65979743
158cranial nerve morphogenesis (GO:0021602)2.65518923
159sodium ion export (GO:0071436)2.64238334
160positive regulation of neurotransmitter transport (GO:0051590)2.63277575
161positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62959114
162presynaptic membrane organization (GO:0097090)2.62657100
163signal complex assembly (GO:0007172)2.62571331
164regulation of phospholipid biosynthetic process (GO:0071071)2.61276368
165startle response (GO:0001964)2.60390457
166nephron tubule morphogenesis (GO:0072078)2.58726880
167nephron epithelium morphogenesis (GO:0072088)2.58726880
168ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.58386582
169nucleoside bisphosphate biosynthetic process (GO:0033866)2.58386582
170purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.58386582
171sympathetic nervous system development (GO:0048485)2.57114702
172urogenital system development (GO:0001655)2.56964251
173regulation of action potential (GO:0098900)2.56364775
174cilium or flagellum-dependent cell motility (GO:0001539)2.53740145
175nucleoside transport (GO:0015858)2.51558877
176G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.48539932
177positive regulation of cAMP biosynthetic process (GO:0030819)2.47131873
178phasic smooth muscle contraction (GO:0014821)2.46597459
179dermatan sulfate metabolic process (GO:0030205)2.42660350
180positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42059691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18222457
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.30621434
3VDR_21846776_ChIP-Seq_THP-1_Human3.61143229
4GBX2_23144817_ChIP-Seq_PC3_Human3.53309183
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.20454651
6P68_20966046_ChIP-Seq_HELA_Human2.91885529
7LXR_22292898_ChIP-Seq_THP-1_Human2.88053437
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70395901
9REST_21632747_ChIP-Seq_MESCs_Mouse2.66712829
10CTCF_27219007_Chip-Seq_Bcells_Human2.65740712
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65629350
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57956558
13DROSHA_22980978_ChIP-Seq_HELA_Human2.50869688
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47609872
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41694228
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39129047
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39129047
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38871031
19MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.38428736
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37940259
21* RARB_27405468_Chip-Seq_BRAIN_Mouse2.26461304
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26212070
23* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25834563
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.25204014
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25185183
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20872258
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19892100
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19835498
29MAF_26560356_Chip-Seq_TH2_Human2.16671406
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.15948723
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07413649
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.07286321
33E2F1_20622854_ChIP-Seq_HELA_Human2.06583768
34BCL6_27268052_Chip-Seq_Bcells_Human2.05919388
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05048085
36IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01617646
37REST_18959480_ChIP-ChIP_MESCs_Mouse2.00645669
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99742092
39PHF8_20622854_ChIP-Seq_HELA_Human1.97879811
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.96931291
41SMC4_20622854_ChIP-Seq_HELA_Human1.96243389
42BCOR_27268052_Chip-Seq_Bcells_Human1.95680588
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95546575
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92283121
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.87222897
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84390456
47RARB_24833708_ChIP-Seq_LIVER_Mouse1.82911530
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.81480251
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.77077439
50KDM2B_26808549_Chip-Seq_DND41_Human1.77048364
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.76844692
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.76529433
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.73634962
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72811103
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.72578493
56AR_21572438_ChIP-Seq_LNCaP_Human1.70262357
57RACK7_27058665_Chip-Seq_MCF-7_Human1.68786077
58RARA_24833708_ChIP-Seq_LIVER_Mouse1.67332554
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64066937
60* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62838705
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.62567238
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.62426017
63TP53_22127205_ChIP-Seq_IMR90_Human1.61799173
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58710073
65* VDR_24763502_ChIP-Seq_THP-1_Human1.55816408
66FOXP1_21924763_ChIP-Seq_HESCs_Human1.53975996
67SMAD4_21799915_ChIP-Seq_A2780_Human1.53729932
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53482016
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.52358775
70ERA_21632823_ChIP-Seq_H3396_Human1.52214789
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51783284
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51650941
73RXRA_24833708_ChIP-Seq_LIVER_Mouse1.51362553
74CREB1_26743006_Chip-Seq_LNCaP_Human1.51353314
75MAF_26560356_Chip-Seq_TH1_Human1.50908050
76NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.50899847
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.47973129
78CTCF_20526341_ChIP-Seq_ESCs_Human1.47038321
79* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.46450837
80RNF2_27304074_Chip-Seq_NSC_Mouse1.45873516
81OCT4_19829295_ChIP-Seq_ESCs_Human1.41162457
82XRN2_22483619_ChIP-Seq_HELA_Human1.40127938
83TP53_23651856_ChIP-Seq_MEFs_Mouse1.39502230
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.39275373
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38629150
86CTCF_21964334_Chip-Seq_Bcells_Human1.38137228
87SA1_27219007_Chip-Seq_Bcells_Human1.37668862
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.37199467
89CTCF_21964334_ChIP-Seq_BJAB-B_Human1.34796426
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34784222
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34720613
92* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33884998
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33483714
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32259086
95STAT3_23295773_ChIP-Seq_U87_Human1.30600908
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30433457
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29201467
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.28306765
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27414656
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27204489
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27061346
102AR_19668381_ChIP-Seq_PC3_Human1.26045681
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25799655
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25577794
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22768651
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.21298296
107* TP63_22573176_ChIP-Seq_HFKS_Human1.21047600
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20924796
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.20912741
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20195970
111TCF4_23295773_ChIP-Seq_U87_Human1.19381413
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19084379
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.18967879
114* TCF7_22412390_ChIP-Seq_EML_Mouse1.18703983
115P300_19829295_ChIP-Seq_ESCs_Human1.18201575
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18191615
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18181976
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17100449
119KDM2B_26808549_Chip-Seq_K562_Human1.16426906
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14372757
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14245273
122* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14190524
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.12828103
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.10534416
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09413608
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09245360
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.09099513
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08869717
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08812423
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08590378
131AR_25329375_ChIP-Seq_VCAP_Human1.07830850
132KLF4_19829295_ChIP-Seq_ESCs_Human1.07513298
133AHR_22903824_ChIP-Seq_MCF-7_Human1.07294669
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06574443
135UTX_26944678_Chip-Seq_JUKART_Human1.06277614
136OCT4_20526341_ChIP-Seq_ESCs_Human1.06029863
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.05792954
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05559645
139P53_21459846_ChIP-Seq_SAOS-2_Human1.04381467
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04248900
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04157873
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03934210
143* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03691958
144TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02959405
145ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02917838
146ZNF274_21170338_ChIP-Seq_K562_Hela1.02668479
147NANOG_18555785_Chip-Seq_ESCs_Mouse1.01027660
148ARNT_22903824_ChIP-Seq_MCF-7_Human1.00905498
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00427225
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00339226
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00166604
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.95291223
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94022700
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94022700
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93688681
156* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93674055
157TET1_21490601_ChIP-Seq_MESCs_Mouse0.93040492
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.90373991
159RUNX2_22187159_ChIP-Seq_PCA_Human0.90154811
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89593245
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88705822
162DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88389103
163OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88336302
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87760029
165FUS_26573619_Chip-Seq_HEK293_Human0.87163177
166PIAS1_25552417_ChIP-Seq_VCAP_Human0.86102893
167DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86090002
168SMAD3_21741376_ChIP-Seq_ESCs_Human0.85953971
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85692601
170IGF1R_20145208_ChIP-Seq_DFB_Human0.84351100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.29606860
2MP0003136_yellow_coat_color6.04072876
3MP0004859_abnormal_synaptic_plasticity5.71474823
4MP0003635_abnormal_synaptic_transmissio3.56270570
5MP0003880_abnormal_central_pattern3.51170939
6MP0009046_muscle_twitch3.11724399
7MP0002063_abnormal_learning/memory/cond3.04840305
8MP0005423_abnormal_somatic_nervous2.90955277
9MP0004270_analgesia2.90813969
10MP0009745_abnormal_behavioral_response2.86783082
11MP0002064_seizures2.67923320
12MP0002572_abnormal_emotion/affect_behav2.61034066
13MP0001486_abnormal_startle_reflex2.37663523
14MP0001968_abnormal_touch/_nociception2.27056194
15MP0002734_abnormal_mechanical_nocicepti2.25602178
16MP0002272_abnormal_nervous_system2.20122794
17MP0005171_absent_coat_pigmentation2.15181775
18MP0005645_abnormal_hypothalamus_physiol2.08395798
19MP0003787_abnormal_imprinting2.07624368
20MP0002735_abnormal_chemical_nociception2.04859284
21* MP0000778_abnormal_nervous_system2.01036487
22MP0004381_abnormal_hair_follicle1.92835460
23MP0001188_hyperpigmentation1.92052184
24MP0002184_abnormal_innervation1.91787808
25MP0005646_abnormal_pituitary_gland1.88701571
26MP0000751_myopathy1.87390887
27MP0008569_lethality_at_weaning1.83777173
28MP0001756_abnormal_urination1.83565687
29MP0002067_abnormal_sensory_capabilities1.82921137
30MP0002733_abnormal_thermal_nociception1.78780864
31MP0001501_abnormal_sleep_pattern1.76962471
32MP0005083_abnormal_biliary_tract1.75745433
33MP0001958_emphysema1.74338520
34MP0001970_abnormal_pain_threshold1.70933710
35* MP0004811_abnormal_neuron_physiology1.68584621
36MP0000955_abnormal_spinal_cord1.68152244
37MP0002736_abnormal_nociception_after1.65277517
38MP0002557_abnormal_social/conspecific_i1.64838770
39MP0000538_abnormal_urinary_bladder1.63997549
40MP0001502_abnormal_circadian_rhythm1.59160825
41MP0004130_abnormal_muscle_cell1.59072908
42MP0001440_abnormal_grooming_behavior1.57719476
43MP0004924_abnormal_behavior1.55406313
44MP0005386_behavior/neurological_phenoty1.55406313
45MP0006292_abnormal_olfactory_placode1.53549354
46MP0000013_abnormal_adipose_tissue1.51782233
47MP0002822_catalepsy1.49112009
48MP0001984_abnormal_olfaction1.46069582
49MP0002882_abnormal_neuron_morphology1.46041943
50MP0000569_abnormal_digit_pigmentation1.45200192
51MP0004043_abnormal_pH_regulation1.40921050
52MP0009780_abnormal_chondrocyte_physiolo1.40432916
53MP0006276_abnormal_autonomic_nervous1.36664068
54MP0006072_abnormal_retinal_apoptosis1.33363021
55MP0002066_abnormal_motor_capabilities/c1.28446218
56MP0004142_abnormal_muscle_tone1.27924383
57MP0003283_abnormal_digestive_organ1.27325541
58MP0003705_abnormal_hypodermis_morpholog1.24940155
59MP0002638_abnormal_pupillary_reflex1.24133151
60MP0010030_abnormal_orbit_morphology1.23928633
61MP0004858_abnormal_nervous_system1.20584004
62MP0004233_abnormal_muscle_weight1.19142452
63* MP0002152_abnormal_brain_morphology1.18709898
64MP0008875_abnormal_xenobiotic_pharmacok1.17784654
65MP0003890_abnormal_embryonic-extraembry1.17473621
66MP0005394_taste/olfaction_phenotype1.15992229
67MP0005499_abnormal_olfactory_system1.15992229
68MP0005551_abnormal_eye_electrophysiolog1.15648487
69MP0000015_abnormal_ear_pigmentation1.12160299
70MP0004885_abnormal_endolymph1.12115511
71MP0008877_abnormal_DNA_methylation1.10576194
72MP0010386_abnormal_urinary_bladder1.09478984
73MP0003122_maternal_imprinting1.09240859
74MP0000631_abnormal_neuroendocrine_gland1.08265168
75MP0000750_abnormal_muscle_regeneration1.05483502
76MP0003633_abnormal_nervous_system1.05314018
77MP0000003_abnormal_adipose_tissue1.04417324
78MP0002752_abnormal_somatic_nervous0.93470159
79MP0002751_abnormal_autonomic_nervous0.91957938
80MP0005253_abnormal_eye_physiology0.91811449
81MP0008995_early_reproductive_senescence0.91662415
82MP0003879_abnormal_hair_cell0.90531297
83MP0001664_abnormal_digestion0.90441018
84MP0001177_atelectasis0.90391501
85MP0004133_heterotaxia0.89710913
86MP0002909_abnormal_adrenal_gland0.89570525
87MP0003861_abnormal_nervous_system0.89106317
88* MP0003631_nervous_system_phenotype0.88113569
89MP0003137_abnormal_impulse_conducting0.86284792
90MP0003279_aneurysm0.85334407
91MP0001963_abnormal_hearing_physiology0.80031362
92MP0005623_abnormal_meninges_morphology0.79975394
93MP0004742_abnormal_vestibular_system0.79408478
94MP0009384_cardiac_valve_regurgitation0.77806996
95MP0002653_abnormal_ependyma_morphology0.76669371
96MP0002928_abnormal_bile_duct0.76400744
97MP0003121_genomic_imprinting0.75986659
98MP0008057_abnormal_DNA_replication0.75782192
99MP0003045_fibrosis0.75373162
100MP0002229_neurodegeneration0.75258413
101MP0002009_preneoplasia0.73638253
102MP0005174_abnormal_tail_pigmentation0.72352945
103MP0005076_abnormal_cell_differentiation0.72211515
104MP0005503_abnormal_tendon_morphology0.72166064
105MP0003634_abnormal_glial_cell0.72129812
106MP0001765_abnormal_ion_homeostasis0.71397348
107MP0002069_abnormal_eating/drinking_beha0.70516794
108MP0002933_joint_inflammation0.67405073
109MP0003119_abnormal_digestive_system0.67322144
110MP0001485_abnormal_pinna_reflex0.66924620
111* MP0010769_abnormal_survival0.66570196
112MP0001529_abnormal_vocalization0.66372718
113* MP0010768_mortality/aging0.65975117
114MP0003385_abnormal_body_wall0.65651900
115* MP0002082_postnatal_lethality0.65194155
116* MP0010770_preweaning_lethality0.65194155
117MP0003091_abnormal_cell_migration0.64903634
118MP0000026_abnormal_inner_ear0.64367307
119MP0001943_abnormal_respiration0.64005856
120MP0005409_darkened_coat_color0.63894445
121MP0002160_abnormal_reproductive_system0.63550082
122MP0001348_abnormal_lacrimal_gland0.63296968
123MP0001905_abnormal_dopamine_level0.63145998
124MP0004145_abnormal_muscle_electrophysio0.62019908
125MP0002249_abnormal_larynx_morphology0.61488920
126MP0003329_amyloid_beta_deposits0.60464564
127MP0000747_muscle_weakness0.58763837
128MP0000470_abnormal_stomach_morphology0.55223675
129MP0002075_abnormal_coat/hair_pigmentati0.54460977
130MP0005084_abnormal_gallbladder_morpholo0.54270921
131MP0003878_abnormal_ear_physiology0.53326009
132MP0005377_hearing/vestibular/ear_phenot0.53326009
133MP0003172_abnormal_lysosome_physiology0.51564162
134MP0003453_abnormal_keratinocyte_physiol0.50897495
135MP0005332_abnormal_amino_acid0.50247991
136MP0001661_extended_life_span0.50072354
137MP0005257_abnormal_intraocular_pressure0.47237852
138MP0001299_abnormal_eye_distance/0.44373538
139MP0009278_abnormal_bone_marrow0.44159398
140MP0005167_abnormal_blood-brain_barrier0.43985178
141MP0001270_distended_abdomen0.43537474
142MP0005365_abnormal_bile_salt0.42395941
143MP0000367_abnormal_coat/_hair0.40755936
144MP0000427_abnormal_hair_cycle0.40710108
145MP0000767_abnormal_smooth_muscle0.39034630

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.33131724
2Congenital stationary night blindness (HP:0007642)5.23857779
3Testicular atrophy (HP:0000029)5.22434348
4Febrile seizures (HP:0002373)5.16602969
5Attenuation of retinal blood vessels (HP:0007843)5.05474745
6Rectal fistula (HP:0100590)4.96845370
7Rectovaginal fistula (HP:0000143)4.96845370
8Ulnar bowing (HP:0003031)4.85420374
9Thin bony cortex (HP:0002753)4.85003342
10Poikiloderma (HP:0001029)4.68987742
11Myokymia (HP:0002411)4.67105522
12Vaginal fistula (HP:0004320)4.38991181
13Focal seizures (HP:0007359)4.33571224
14Epileptic encephalopathy (HP:0200134)4.30337913
15Akinesia (HP:0002304)4.21735837
16Progressive cerebellar ataxia (HP:0002073)4.04300634
17Chorioretinal atrophy (HP:0000533)4.02710266
18Atonic seizures (HP:0010819)3.96528706
19Visual hallucinations (HP:0002367)3.83799813
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.78638400
21Patellar aplasia (HP:0006443)3.75597826
22Bony spicule pigmentary retinopathy (HP:0007737)3.73635379
23Facial diplegia (HP:0001349)3.63152910
24Aplasia of the musculature (HP:0100854)3.52845915
25Aplasia/Hypoplasia of the patella (HP:0006498)3.44367142
26Dyschromatopsia (HP:0007641)3.34911059
27Action tremor (HP:0002345)3.31830603
28Absence seizures (HP:0002121)3.25558333
29Popliteal pterygium (HP:0009756)3.22752713
30Squamous cell carcinoma (HP:0002860)3.19981779
31Broad-based gait (HP:0002136)3.14692156
32Annular pancreas (HP:0001734)3.13160107
33Joint stiffness (HP:0001387)3.10905793
34Gaze-evoked nystagmus (HP:0000640)3.10104755
35Abnormality of the intrinsic pathway (HP:0010989)2.99641985
36Genetic anticipation (HP:0003743)2.87522394
37Enlarged epiphyses (HP:0010580)2.86259972
38Delayed epiphyseal ossification (HP:0002663)2.84855798
39Birth length less than 3rd percentile (HP:0003561)2.82666556
40Dialeptic seizures (HP:0011146)2.81514727
41Bowing of the arm (HP:0006488)2.71363527
42Bowed forearm bones (HP:0003956)2.71363527
43Polydipsia (HP:0001959)2.70168975
44Abnormal drinking behavior (HP:0030082)2.70168975
45Abnormality of the costochondral junction (HP:0000919)2.68298821
46Abnormal albumin level (HP:0012116)2.68154336
47Hypoalbuminemia (HP:0003073)2.68154336
48Mesangial abnormality (HP:0001966)2.65291147
49Myotonia (HP:0002486)2.65246437
50Increased number of teeth (HP:0011069)2.64458820
51Choanal stenosis (HP:0000452)2.60662952
52Generalized tonic-clonic seizures (HP:0002069)2.54639923
53Fetal akinesia sequence (HP:0001989)2.54125524
54Capillary hemangiomas (HP:0005306)2.53375617
55Dysdiadochokinesis (HP:0002075)2.52166681
56Obstructive sleep apnea (HP:0002870)2.46000850
57Atrioventricular block (HP:0001678)2.44279605
58Aqueductal stenosis (HP:0002410)2.43070279
59Tubular atrophy (HP:0000092)2.39286236
60Impaired smooth pursuit (HP:0007772)2.35314471
61Flat occiput (HP:0005469)2.29818447
62Male infertility (HP:0003251)2.28667982
63Premature graying of hair (HP:0002216)2.24382825
64Absent thumb (HP:0009777)2.21586225
65Decreased circulating renin level (HP:0003351)2.20914877
66Narrow nasal bridge (HP:0000446)2.19511489
67Abnormality of the lower motor neuron (HP:0002366)2.19303955
68Pendular nystagmus (HP:0012043)2.18450854
69Neonatal respiratory distress (HP:0002643)2.18379149
70Poor eye contact (HP:0000817)2.17978792
71Volvulus (HP:0002580)2.17871657
72Thin ribs (HP:0000883)2.17124761
73Ankle clonus (HP:0011448)2.16679073
74Basal cell carcinoma (HP:0002671)2.16258907
75Mutism (HP:0002300)2.15952291
76Short humerus (HP:0005792)2.15874251
77Decreased central vision (HP:0007663)2.15063366
78Urinary bladder sphincter dysfunction (HP:0002839)2.14477847
79Abnormality of the labia minora (HP:0012880)2.11492890
80Hemorrhage of the eye (HP:0011885)2.11472030
81Depression (HP:0000716)2.09387624
82Widely patent fontanelles and sutures (HP:0004492)2.08880160
83Impaired vibration sensation in the lower limbs (HP:0002166)2.08689640
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08384224
85Hypoplasia of the pons (HP:0012110)2.05009092
86Hemiparesis (HP:0001269)2.04863016
87Protruding tongue (HP:0010808)2.04254002
88Intestinal atresia (HP:0011100)2.03922019
89Excessive salivation (HP:0003781)2.02537995
90Drooling (HP:0002307)2.02537995
91Abnormality of ocular smooth pursuit (HP:0000617)2.02095475
92Dysmetria (HP:0001310)2.01773925
93Gait imbalance (HP:0002141)2.01256551
94Scanning speech (HP:0002168)2.01167859
95Small hand (HP:0200055)2.00386578
96Sleep apnea (HP:0010535)2.00099618
97Supranuclear gaze palsy (HP:0000605)1.98644556
98Truncal ataxia (HP:0002078)1.98295621
99Breast hypoplasia (HP:0003187)1.98132303
100Absent speech (HP:0001344)1.97960176
101Hypophosphatemic rickets (HP:0004912)1.96444340
102Polyuria (HP:0000103)1.95457354
103Postural instability (HP:0002172)1.91950759
104Joint hemorrhage (HP:0005261)1.91674386
105Zonular cataract (HP:0010920)1.90912512
106Hypoplasia of the ulna (HP:0003022)1.90276420
107Alacrima (HP:0000522)1.89159758
108Absent radius (HP:0003974)1.89041460
109Stereotypic behavior (HP:0000733)1.88993735
110Amblyopia (HP:0000646)1.88246925
111Aplasia/hypoplasia of the humerus (HP:0006507)1.87481082
112Specific learning disability (HP:0001328)1.86528245
113Turricephaly (HP:0000262)1.86072957
114Spina bifida occulta (HP:0003298)1.85618730
115Abnormality of the pons (HP:0007361)1.85604509
116Abnormality of the aortic arch (HP:0012303)1.85435077
117Rib fusion (HP:0000902)1.85362871
118Abnormality of polysaccharide metabolism (HP:0011012)1.84797494
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84797494
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84797494
121Chronic hepatic failure (HP:0100626)1.83279238
122Rectal prolapse (HP:0002035)1.82517603
123Tented upper lip vermilion (HP:0010804)1.82517023
124Abnormal social behavior (HP:0012433)1.81554080
125Impaired social interactions (HP:0000735)1.81554080
126Diplopia (HP:0000651)1.81213516
127Abnormality of binocular vision (HP:0011514)1.81213516
128Abnormal eating behavior (HP:0100738)1.79906157
129Hemiplegia (HP:0002301)1.79657687
130Progressive sensorineural hearing impairment (HP:0000408)1.79586738
131Aplasia involving bones of the upper limbs (HP:0009823)1.79332575
132Aplasia of the phalanges of the hand (HP:0009802)1.79332575
133Aplasia involving bones of the extremities (HP:0009825)1.79332575
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79090505
135Aplasia involving forearm bones (HP:0009822)1.78593218
136Absent forearm bone (HP:0003953)1.78593218
137Heart block (HP:0012722)1.77806131
138Pointed chin (HP:0000307)1.77557000
139Abnormality of the hepatic vasculature (HP:0006707)1.77488178
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76836945
141Urinary glycosaminoglycan excretion (HP:0003541)1.76511250
142Mucopolysacchariduria (HP:0008155)1.76511250
143Lower limb amyotrophy (HP:0007210)1.76065637
144Intention tremor (HP:0002080)1.75171853
145Prolonged partial thromboplastin time (HP:0003645)1.73876621
146Neoplasm of the adrenal cortex (HP:0100641)1.73671616
147Hypoplasia of the radius (HP:0002984)1.73019399
148Choroideremia (HP:0001139)1.72623003
149Broad metatarsal (HP:0001783)1.72126236
150Epileptiform EEG discharges (HP:0011182)1.71786489
151Abnormality of the astrocytes (HP:0100707)1.71719569
152Astrocytoma (HP:0009592)1.71719569
153Abnormal EKG (HP:0003115)1.71534109
154Failure to thrive in infancy (HP:0001531)1.70811635
155Genu recurvatum (HP:0002816)1.67667398
156EEG with generalized epileptiform discharges (HP:0011198)1.67479776
157Neonatal onset (HP:0003623)1.66939692
158Anteriorly placed anus (HP:0001545)1.66769045
159Abnormal atrioventricular conduction (HP:0005150)1.66393955
160Decreased lacrimation (HP:0000633)1.66278898
161Congenital primary aphakia (HP:0007707)1.64527988
162Dysmetric saccades (HP:0000641)1.64415129
163Deeply set eye (HP:0000490)1.63215077
164Intestinal fistula (HP:0100819)1.61260309
165Increased IgM level (HP:0003496)1.60823563
166Abnormality of the nasal septum (HP:0000419)1.60508789
167Incomplete penetrance (HP:0003829)1.60240771
168Septo-optic dysplasia (HP:0100842)1.58400472
169Hypsarrhythmia (HP:0002521)1.58130533
170Coronal craniosynostosis (HP:0004440)1.57976672
171Gastroesophageal reflux (HP:0002020)1.57695912
172Impaired vibratory sensation (HP:0002495)1.57468735
173Median cleft lip (HP:0000161)1.57443371
174Anxiety (HP:0000739)1.56680223
175Short chin (HP:0000331)1.56651733
176Bradykinesia (HP:0002067)1.54572108
177Limb dystonia (HP:0002451)1.53789908
178Medial flaring of the eyebrow (HP:0010747)1.52905832
179Abnormality of the periventricular white matter (HP:0002518)1.52307981
180Thickened helices (HP:0000391)1.51153784
181Facial hemangioma (HP:0000329)1.50551390
182Hyperventilation (HP:0002883)1.50172145
183Nephrogenic diabetes insipidus (HP:0009806)1.49675228
184Lower limb muscle weakness (HP:0007340)1.49337269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.31135916
2NTRK33.85235726
3MARK13.04329101
4EPHA42.90294742
5MAP3K92.85780529
6BLK2.51850126
7MAP3K62.35997537
8MINK12.30778836
9PINK12.25715362
10MAP2K72.25329734
11MAP3K42.18253975
12ICK2.17460906
13PRPF4B2.14445578
14ACVR1B2.13453391
15DAPK22.11639790
16TLK12.07466401
17DAPK12.06969729
18DDR22.04955393
19GRK62.01344141
20CASK2.00941733
21MUSK1.93328180
22UHMK11.93173836
23NTRK21.92077100
24TRIB31.85016836
25PAK61.81991171
26AKT31.81297537
27ERBB31.80298774
28CDK121.79110029
29TYRO31.64132411
30ADRBK21.63531916
31TNIK1.61919998
32ADRBK11.51990082
33FRK1.48583873
34BMPR1B1.47335886
35STK381.45368136
36SGK21.44872620
37MAPK131.42083843
38MAPK151.34720329
39CAMKK11.29531303
40PHKG11.28275251
41PHKG21.28275251
42CDK51.27348964
43PRKD31.22038228
44SIK21.21032329
45SIK11.19735941
46ZAP701.18925166
47PLK21.18322599
48TESK21.16567016
49SGK2231.16454816
50SGK4941.16454816
51FGR1.16324852
52LATS21.15464490
53YES11.13304805
54CDC42BPA1.11929452
55KSR11.11211895
56SGK31.08973037
57BMPR21.08113161
58MAPK121.06453792
59SIK31.05571281
60MAP2K41.02126236
61PDPK10.99353873
62MAP2K30.98108319
63NTRK10.98106556
64PRKD20.97875756
65SGK10.97807666
66NEK60.94019335
67PRKCG0.91486024
68DYRK1B0.89991298
69ERN10.88228170
70MATK0.84357820
71CAMK2A0.83795168
72CDK180.83500948
73DYRK1A0.83026316
74RIPK40.82633403
75MELK0.80599308
76ALK0.78653537
77CDK150.78582867
78CAMKK20.78147935
79GRK50.78012324
80BRD40.76392831
81PRKD10.75358350
82BMX0.73713297
83PDGFRA0.72799503
84MKNK20.71385948
85CAMK10.70162172
86CAMK2B0.69153696
87CDK11A0.67468637
88MAP3K70.66775294
89MAPK110.66554082
90MAPK100.65645439
91FES0.65528307
92CDK140.65202381
93MAP3K120.64839275
94CSNK1D0.62415737
95RIPK10.61588470
96OXSR10.61450861
97NEK20.61347633
98BCR0.61278015
99STK110.61104625
100FGFR20.56774086
101TGFBR10.56283003
102GRK10.55909761
103CCNB10.55377919
104RPS6KB10.55070169
105INSRR0.54811860
106PRKCH0.54608208
107MTOR0.54317923
108CAMK40.52502379
109MARK20.51857178
110RPS6KA30.51525173
111WNK10.51221983
112MAP3K130.50205221
113TIE10.49731070
114TAOK20.49671346
115CDK190.49319003
116STK390.49037068
117EEF2K0.48938900
118ZAK0.47696773
119PRKCZ0.47667312
120HIPK20.46606626
121CAMK2D0.45210314
122MAPK70.45105595
123RPS6KL10.45102713
124RPS6KC10.45102713
125GSK3B0.44965984
126RPS6KA20.44863995
127DYRK20.44559009
128STK160.42040345
129CAMK2G0.41800920
130PDGFRB0.41384316
131IRAK20.41329501
132TNK20.41222342
133PKN10.40040487
134PRKCE0.39841507
135CLK10.39375548
136MAPK80.38721308
137PRKAA10.37452364
138CAMK1G0.37369570
139MAPK140.37057334
140CAMK1D0.36463036
141MAP2K60.36421631
142PTK2B0.35252382
143RPS6KA60.35040463
144ERBB20.34958043
145ROCK10.33827329

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.08490916
2Nicotine addiction_Homo sapiens_hsa050333.68483713
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.06515010
4Synaptic vesicle cycle_Homo sapiens_hsa047212.76631622
5Olfactory transduction_Homo sapiens_hsa047402.63350543
6Circadian entrainment_Homo sapiens_hsa047132.44042255
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43002540
8GABAergic synapse_Homo sapiens_hsa047272.41216478
9Glutamatergic synapse_Homo sapiens_hsa047242.37544453
10Morphine addiction_Homo sapiens_hsa050322.36359008
11Long-term potentiation_Homo sapiens_hsa047202.25444743
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.20813043
13Amphetamine addiction_Homo sapiens_hsa050312.13979539
14Dopaminergic synapse_Homo sapiens_hsa047281.88216989
15Taste transduction_Homo sapiens_hsa047421.87909948
16Salivary secretion_Homo sapiens_hsa049701.82095492
17Insulin secretion_Homo sapiens_hsa049111.81397555
18Cholinergic synapse_Homo sapiens_hsa047251.73781886
19Fructose and mannose metabolism_Homo sapiens_hsa000511.66718380
20Long-term depression_Homo sapiens_hsa047301.65418019
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61091550
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59172242
23Gastric acid secretion_Homo sapiens_hsa049711.53170284
24Serotonergic synapse_Homo sapiens_hsa047261.48021077
25Calcium signaling pathway_Homo sapiens_hsa040201.43762284
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43580120
27Oxytocin signaling pathway_Homo sapiens_hsa049211.41341837
28Phototransduction_Homo sapiens_hsa047441.38756138
29GnRH signaling pathway_Homo sapiens_hsa049121.34879359
30Gap junction_Homo sapiens_hsa045401.33506197
31Renin secretion_Homo sapiens_hsa049241.30865482
32Cocaine addiction_Homo sapiens_hsa050301.28379523
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24561204
34ErbB signaling pathway_Homo sapiens_hsa040121.24547221
35Circadian rhythm_Homo sapiens_hsa047101.24265914
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23503413
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23124057
38Axon guidance_Homo sapiens_hsa043601.23007080
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22783487
40Sphingolipid metabolism_Homo sapiens_hsa006001.21174366
41cAMP signaling pathway_Homo sapiens_hsa040241.19109543
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15850662
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14312817
44Type II diabetes mellitus_Homo sapiens_hsa049301.11763516
45Oocyte meiosis_Homo sapiens_hsa041141.11162941
46Melanogenesis_Homo sapiens_hsa049161.10642366
47Fatty acid biosynthesis_Homo sapiens_hsa000611.10027103
48Wnt signaling pathway_Homo sapiens_hsa043101.07631708
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07398973
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05353564
51Estrogen signaling pathway_Homo sapiens_hsa049151.01252001
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01091372
53Lysine degradation_Homo sapiens_hsa003100.95506008
54Glioma_Homo sapiens_hsa052140.95073799
55Hedgehog signaling pathway_Homo sapiens_hsa043400.94692407
56Other glycan degradation_Homo sapiens_hsa005110.91199335
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89438456
58Choline metabolism in cancer_Homo sapiens_hsa052310.88391644
59* MAPK signaling pathway_Homo sapiens_hsa040100.88146834
60Ovarian steroidogenesis_Homo sapiens_hsa049130.87960991
61Dorso-ventral axis formation_Homo sapiens_hsa043200.86395256
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86226867
63Hippo signaling pathway_Homo sapiens_hsa043900.84618034
64ABC transporters_Homo sapiens_hsa020100.82367823
65mTOR signaling pathway_Homo sapiens_hsa041500.81482339
66Collecting duct acid secretion_Homo sapiens_hsa049660.79455433
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77303632
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75774131
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73299733
70Endometrial cancer_Homo sapiens_hsa052130.72790521
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71802787
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71308670
73mRNA surveillance pathway_Homo sapiens_hsa030150.70497435
74Colorectal cancer_Homo sapiens_hsa052100.70460915
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69438367
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67867470
77Dilated cardiomyopathy_Homo sapiens_hsa054140.67155894
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66522589
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.66444848
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.66397315
81Lysosome_Homo sapiens_hsa041420.65089771
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.64177580
83Basal cell carcinoma_Homo sapiens_hsa052170.63414260
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.62311232
85Thyroid hormone synthesis_Homo sapiens_hsa049180.61481825
86Ras signaling pathway_Homo sapiens_hsa040140.61246772
87Rap1 signaling pathway_Homo sapiens_hsa040150.60927508
88Inositol phosphate metabolism_Homo sapiens_hsa005620.60612254
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59557522
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58661369
91Pancreatic secretion_Homo sapiens_hsa049720.58225896
92Alcoholism_Homo sapiens_hsa050340.56603392
93VEGF signaling pathway_Homo sapiens_hsa043700.56086568
94Type I diabetes mellitus_Homo sapiens_hsa049400.55528101
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53788106
96Notch signaling pathway_Homo sapiens_hsa043300.52259691
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51178405
98Vitamin digestion and absorption_Homo sapiens_hsa049770.49760905
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48023962
100Vibrio cholerae infection_Homo sapiens_hsa051100.47307072
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46454980
102Adherens junction_Homo sapiens_hsa045200.46428498
103Chemokine signaling pathway_Homo sapiens_hsa040620.46052445
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45905718
105Bile secretion_Homo sapiens_hsa049760.45141615
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44943723
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43703044
108Cardiac muscle contraction_Homo sapiens_hsa042600.43070638
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42639363
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42233208
111Insulin signaling pathway_Homo sapiens_hsa049100.42067501
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.41310860
113Tight junction_Homo sapiens_hsa045300.41027963
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40557293
115Endocytosis_Homo sapiens_hsa041440.39765961
116Nitrogen metabolism_Homo sapiens_hsa009100.39650305
117Prolactin signaling pathway_Homo sapiens_hsa049170.37811230
118Glucagon signaling pathway_Homo sapiens_hsa049220.36491922
119Fanconi anemia pathway_Homo sapiens_hsa034600.35251837
120Melanoma_Homo sapiens_hsa052180.35135403
121ECM-receptor interaction_Homo sapiens_hsa045120.34009297
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33178560
123FoxO signaling pathway_Homo sapiens_hsa040680.30751321
124TGF-beta signaling pathway_Homo sapiens_hsa043500.30103121
125Ether lipid metabolism_Homo sapiens_hsa005650.29354419
126Linoleic acid metabolism_Homo sapiens_hsa005910.24420253
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23884256

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