MAP3K10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.64389682
2locomotory exploration behavior (GO:0035641)6.40042427
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20570323
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75920377
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.73777615
6vocalization behavior (GO:0071625)5.42353984
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23887295
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.23141802
9layer formation in cerebral cortex (GO:0021819)5.15974985
10glutamate secretion (GO:0014047)5.08657433
11synaptic vesicle exocytosis (GO:0016079)4.96409831
12regulation of synaptic vesicle exocytosis (GO:2000300)4.90836798
13regulation of glutamate receptor signaling pathway (GO:1900449)4.88411886
14regulation of synapse structural plasticity (GO:0051823)4.84104536
15exploration behavior (GO:0035640)4.68734116
16dendritic spine morphogenesis (GO:0060997)4.56908478
17regulation of neuronal synaptic plasticity (GO:0048168)4.55132684
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.51903313
19L-amino acid import (GO:0043092)4.49017709
20protein localization to synapse (GO:0035418)4.46471118
21neurotransmitter secretion (GO:0007269)4.36450561
22cerebellar granule cell differentiation (GO:0021707)4.35382392
23regulation of synaptic vesicle transport (GO:1902803)4.32761657
24amino acid import (GO:0043090)4.21051423
25sodium ion export (GO:0071436)4.14183774
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.07029336
27neurotransmitter-gated ion channel clustering (GO:0072578)4.03977757
28proline transport (GO:0015824)4.00277946
29neuromuscular process controlling balance (GO:0050885)3.95811185
30gamma-aminobutyric acid transport (GO:0015812)3.93306187
31activation of protein kinase A activity (GO:0034199)3.91710953
32cellular potassium ion homeostasis (GO:0030007)3.88484708
33regulation of synapse maturation (GO:0090128)3.87703615
34neuronal action potential propagation (GO:0019227)3.84909210
35regulation of dendritic spine morphogenesis (GO:0061001)3.82869963
36positive regulation of synapse maturation (GO:0090129)3.78139514
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73305162
38synaptic transmission, glutamatergic (GO:0035249)3.72036471
39positive regulation of membrane potential (GO:0045838)3.71280530
40long-term memory (GO:0007616)3.68295182
41regulation of voltage-gated calcium channel activity (GO:1901385)3.65053573
42neuron cell-cell adhesion (GO:0007158)3.61637813
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57745425
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55323044
45axon ensheathment in central nervous system (GO:0032291)3.54763814
46central nervous system myelination (GO:0022010)3.54763814
47auditory behavior (GO:0031223)3.54030171
48potassium ion homeostasis (GO:0055075)3.52356088
49regulation of ARF protein signal transduction (GO:0032012)3.52170384
50cell communication by electrical coupling (GO:0010644)3.49408828
51prepulse inhibition (GO:0060134)3.48675327
52glycine transport (GO:0015816)3.47883133
53negative regulation of dendrite morphogenesis (GO:0050774)3.46109153
54regulation of synaptic plasticity (GO:0048167)3.44660836
55glutamate receptor signaling pathway (GO:0007215)3.44459585
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44213896
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.43105192
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.41570611
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41383131
60dendrite morphogenesis (GO:0048813)3.41365204
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39707387
62neuron-neuron synaptic transmission (GO:0007270)3.37635000
63regulation of postsynaptic membrane potential (GO:0060078)3.32517168
64neurotransmitter transport (GO:0006836)3.31914510
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31133509
66dendritic spine organization (GO:0097061)3.26701995
67response to auditory stimulus (GO:0010996)3.22556524
68cerebellar Purkinje cell layer development (GO:0021680)3.21376349
69regulation of neurotransmitter secretion (GO:0046928)3.18264953
70synaptic vesicle endocytosis (GO:0048488)3.13893198
71neuronal ion channel clustering (GO:0045161)3.12305003
72positive regulation of dendritic spine development (GO:0060999)3.11947706
73regulation of neurotransmitter levels (GO:0001505)3.11616549
74positive regulation of dendrite development (GO:1900006)3.10334301
75regulation of dendritic spine development (GO:0060998)3.09958094
76neuron recognition (GO:0008038)3.09808910
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08985349
78cell migration in hindbrain (GO:0021535)3.06215482
79cytoskeletal anchoring at plasma membrane (GO:0007016)3.06058043
80positive regulation of neurotransmitter secretion (GO:0001956)3.05359645
81regulation of synaptic transmission (GO:0050804)3.04778981
82positive regulation of neurotransmitter transport (GO:0051590)3.04002152
83vesicle transport along microtubule (GO:0047496)3.01986752
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.00262587
85cerebellar Purkinje cell differentiation (GO:0021702)2.99755303
86membrane depolarization during action potential (GO:0086010)2.99262432
87transmission of nerve impulse (GO:0019226)2.99210076
88positive regulation of dendritic spine morphogenesis (GO:0061003)2.98915967
89neuromuscular process (GO:0050905)2.98467758
90neuromuscular process controlling posture (GO:0050884)2.97657922
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95792679
92axonal fasciculation (GO:0007413)2.94824542
93regulation of neurotransmitter transport (GO:0051588)2.94714769
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94709174
95positive regulation of vesicle fusion (GO:0031340)2.92314219
96social behavior (GO:0035176)2.91374594
97intraspecies interaction between organisms (GO:0051703)2.91374594
98establishment of nucleus localization (GO:0040023)2.90269839
99signal complex assembly (GO:0007172)2.90117057
100regulation of vesicle fusion (GO:0031338)2.90066794
101acidic amino acid transport (GO:0015800)2.88719090
102membrane depolarization (GO:0051899)2.88648602
103vesicle docking involved in exocytosis (GO:0006904)2.88080343
104postsynaptic membrane organization (GO:0001941)2.87719285
105establishment of mitochondrion localization (GO:0051654)2.87696799
106potassium ion import (GO:0010107)2.86275051
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83258362
108long-term synaptic potentiation (GO:0060291)2.82708059
109synaptic vesicle transport (GO:0048489)2.82662883
110establishment of synaptic vesicle localization (GO:0097480)2.82662883
111dicarboxylic acid transport (GO:0006835)2.82196943
112regulation of clathrin-mediated endocytosis (GO:2000369)2.81453397
113dopamine receptor signaling pathway (GO:0007212)2.81113443
114regulation of ARF GTPase activity (GO:0032312)2.80976606
115organelle transport along microtubule (GO:0072384)2.79222202
116positive regulation of fibroblast migration (GO:0010763)2.79098797
117cellular sodium ion homeostasis (GO:0006883)2.78786497
118membrane hyperpolarization (GO:0060081)2.77732179
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76626005
120chemosensory behavior (GO:0007635)2.76375848
121regulation of female receptivity (GO:0045924)2.75966441
122regulation of dendrite morphogenesis (GO:0048814)2.75699398
123innervation (GO:0060384)2.75178970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25572837
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.08849836
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.90944625
4DROSHA_22980978_ChIP-Seq_HELA_Human2.80954143
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77344778
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76428682
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75215679
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64914914
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64914914
10REST_21632747_ChIP-Seq_MESCs_Mouse2.63918395
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.60158154
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52217950
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48002031
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46835345
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.28253917
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28106044
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.25980066
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24781067
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.24766634
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23555696
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.19100783
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16209106
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08810669
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.02624293
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95949158
26GBX2_23144817_ChIP-Seq_PC3_Human1.93878175
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90608807
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89877443
29KDM2B_26808549_Chip-Seq_K562_Human1.89834395
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84147456
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.83624399
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81629759
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72870744
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66173953
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65340053
36P68_20966046_ChIP-Seq_HELA_Human1.63576997
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57561630
38AR_21572438_ChIP-Seq_LNCaP_Human1.57003195
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.54366111
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54320165
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50748710
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48661522
43TCF7_22412390_ChIP-Seq_EML_Mouse1.48078001
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.47194906
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43728497
46RACK7_27058665_Chip-Seq_MCF-7_Human1.42347696
47* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40905764
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40282038
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37610164
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35871446
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35715494
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34925547
53LXR_22292898_ChIP-Seq_THP-1_Human1.34532838
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33189225
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.32949989
56* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30669475
57KDM2B_26808549_Chip-Seq_DND41_Human1.30341302
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30004796
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.28591928
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.25999831
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25156216
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24498155
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22154915
64CTCF_27219007_Chip-Seq_Bcells_Human1.21159787
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19676911
66* AR_19668381_ChIP-Seq_PC3_Human1.19450494
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.18345496
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17239493
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.13325258
70ZNF274_21170338_ChIP-Seq_K562_Hela1.13315897
71VDR_21846776_ChIP-Seq_THP-1_Human1.12734332
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.12124251
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.11458052
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11070669
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09817595
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09389192
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08827654
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07730484
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03811892
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03783926
81SMC4_20622854_ChIP-Seq_HELA_Human1.03599170
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01336583
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01313683
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01248235
85SMAD4_21799915_ChIP-Seq_A2780_Human1.00301153
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99544624
87SA1_27219007_Chip-Seq_Bcells_Human0.99335309
88TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98469323
89KLF4_19829295_ChIP-Seq_ESCs_Human0.97572049
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96964234
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96909238
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96858778
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96246379
94* CREB1_26743006_Chip-Seq_LNCaP_Human0.95965908
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95857402
96TP53_23651856_ChIP-Seq_MEFs_Mouse0.95646611
97* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95318407
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94196442
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93582033
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92595603
101TP63_22573176_ChIP-Seq_HFKS_Human0.92052865
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.91556003
103P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91275161
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.91077050
105ZNF263_19887448_ChIP-Seq_K562_Human0.90541851
106* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90531077
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90334038
108OCT4_19829295_ChIP-Seq_ESCs_Human0.90190985
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.89631968
110DPY_21335234_ChIP-Seq_ESCs_Mouse0.89199904
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89128179
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89052837
113BCOR_27268052_Chip-Seq_Bcells_Human0.88879510
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88659367
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.87473873
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87011310
117FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86321801
118CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84675022
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.84200948
120AHR_22903824_ChIP-Seq_MCF-7_Human0.83941847
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83725115
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83410345
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.82345607
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81662212
125STAT3_23295773_ChIP-Seq_U87_Human0.81628393
126* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81104975
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78732579
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78083369
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77961131
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77548741
131RXR_22108803_ChIP-Seq_LS180_Human0.76699060
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.76311340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.48756630
2MP0003635_abnormal_synaptic_transmissio4.25484003
3MP0004270_analgesia3.93150167
4MP0003880_abnormal_central_pattern3.63301704
5MP0002822_catalepsy3.43002024
6MP0002063_abnormal_learning/memory/cond3.38735978
7MP0009745_abnormal_behavioral_response3.23137662
8MP0002064_seizures2.94922601
9MP0009046_muscle_twitch2.78155329
10MP0005423_abnormal_somatic_nervous2.75013995
11MP0002572_abnormal_emotion/affect_behav2.56394434
12MP0001968_abnormal_touch/_nociception2.53303834
13MP0009780_abnormal_chondrocyte_physiolo2.49946958
14MP0002734_abnormal_mechanical_nocicepti2.48670301
15MP0004858_abnormal_nervous_system2.36436097
16MP0001486_abnormal_startle_reflex2.36142144
17MP0002272_abnormal_nervous_system2.22292940
18MP0002909_abnormal_adrenal_gland2.18448831
19MP0003329_amyloid_beta_deposits2.12903267
20MP0004811_abnormal_neuron_physiology2.02636920
21MP0008569_lethality_at_weaning2.01589620
22MP0002733_abnormal_thermal_nociception1.93113233
23MP0001501_abnormal_sleep_pattern1.84600498
24MP0001440_abnormal_grooming_behavior1.81409196
25MP0001970_abnormal_pain_threshold1.78932353
26MP0003283_abnormal_digestive_organ1.78117362
27MP0002736_abnormal_nociception_after1.72892302
28MP0004885_abnormal_endolymph1.70409921
29MP0000955_abnormal_spinal_cord1.68259725
30MP0000778_abnormal_nervous_system1.65032242
31MP0002184_abnormal_innervation1.62723591
32MP0003879_abnormal_hair_cell1.61719735
33MP0002557_abnormal_social/conspecific_i1.61513228
34MP0002735_abnormal_chemical_nociception1.61076657
35MP0002067_abnormal_sensory_capabilities1.57876775
36MP0004924_abnormal_behavior1.55892632
37MP0005386_behavior/neurological_phenoty1.55892632
38MP0008961_abnormal_basal_metabolism1.53950845
39MP0000751_myopathy1.47017725
40MP0003633_abnormal_nervous_system1.43834015
41MP0003123_paternal_imprinting1.40676284
42MP0002066_abnormal_motor_capabilities/c1.39900911
43MP0002882_abnormal_neuron_morphology1.36888063
44MP0002249_abnormal_larynx_morphology1.30958440
45MP0003075_altered_response_to1.29151622
46MP0004145_abnormal_muscle_electrophysio1.22795202
47MP0001346_abnormal_lacrimal_gland1.21670557
48MP0005623_abnormal_meninges_morphology1.19208741
49MP0003631_nervous_system_phenotype1.16211379
50MP0002152_abnormal_brain_morphology1.15466548
51MP0000569_abnormal_digit_pigmentation1.14059525
52MP0000013_abnormal_adipose_tissue1.13797925
53MP0005646_abnormal_pituitary_gland1.10845532
54MP0003787_abnormal_imprinting1.10687204
55MP0004233_abnormal_muscle_weight1.10142095
56MP0005409_darkened_coat_color1.07436382
57MP0010234_abnormal_vibrissa_follicle1.06964874
58MP0001984_abnormal_olfaction1.02128967
59MP0008874_decreased_physiological_sensi1.01377588
60MP0001502_abnormal_circadian_rhythm1.00086845
61MP0004130_abnormal_muscle_cell0.99671410
62MP0000604_amyloidosis0.97427042
63MP0005167_abnormal_blood-brain_barrier0.97212658
64MP0008260_abnormal_autophagy0.95861745
65MP0001177_atelectasis0.95068981
66MP0002069_abnormal_eating/drinking_beha0.94207278
67MP0004085_abnormal_heartbeat0.88418821
68MP0003690_abnormal_glial_cell0.88158962
69MP0008872_abnormal_physiological_respon0.88044171
70MP0004742_abnormal_vestibular_system0.87393889
71MP0003634_abnormal_glial_cell0.87278237
72MP0001963_abnormal_hearing_physiology0.86078484
73MP0003172_abnormal_lysosome_physiology0.84344534
74MP0003137_abnormal_impulse_conducting0.84229635
75MP0000681_abnormal_thyroid_gland0.82990662
76MP0004510_myositis0.82464669
77MP0001348_abnormal_lacrimal_gland0.81244159
78MP0003632_abnormal_nervous_system0.80858170
79MP0000747_muscle_weakness0.80262086
80MP0005645_abnormal_hypothalamus_physiol0.80251768
81MP0002234_abnormal_pharynx_morphology0.79595499
82MP0002229_neurodegeneration0.79384688
83MP0005535_abnormal_body_temperature0.78843288
84MP0002090_abnormal_vision0.78661011
85MP0003045_fibrosis0.78195698
86MP0004142_abnormal_muscle_tone0.77515377
87MP0005187_abnormal_penis_morphology0.75585816
88MP0000678_abnormal_parathyroid_gland0.74882682
89MP0002089_abnormal_postnatal_growth/wei0.72608812
90MP0005166_decreased_susceptibility_to0.72349189
91MP0003705_abnormal_hypodermis_morpholog0.71249803
92MP0005499_abnormal_olfactory_system0.70894068
93MP0005394_taste/olfaction_phenotype0.70894068
94MP0000920_abnormal_myelination0.69376994
95MP0002653_abnormal_ependyma_morphology0.68644575
96MP0003122_maternal_imprinting0.68643926
97MP0006276_abnormal_autonomic_nervous0.67520378
98MP0005058_abnormal_lysosome_morphology0.67061857
99MP0002837_dystrophic_cardiac_calcinosis0.67037335
100MP0001299_abnormal_eye_distance/0.66019015
101MP0003861_abnormal_nervous_system0.64713016
102MP0003303_peritoneal_inflammation0.64130157
103MP0001849_ear_inflammation0.62963327
104MP0004215_abnormal_myocardial_fiber0.62606832
105MP0003646_muscle_fatigue0.60986050
106MP0001529_abnormal_vocalization0.60419609
107MP0005670_abnormal_white_adipose0.59974812
108MP0003183_abnormal_peptide_metabolism0.58905607
109MP0001905_abnormal_dopamine_level0.58007968
110MP0001943_abnormal_respiration0.57820399
111MP0004087_abnormal_muscle_fiber0.57415096
112MP0005375_adipose_tissue_phenotype0.57190627
113MP0000003_abnormal_adipose_tissue0.56827815
114MP0000631_abnormal_neuroendocrine_gland0.56448600
115MP0004484_altered_response_of0.56321432
116MP0010769_abnormal_survival0.55514990
117MP0000534_abnormal_ureter_morphology0.55136617
118MP0000579_abnormal_nail_morphology0.53482827
119MP0005666_abnormal_adipose_tissue0.53327698
120MP0010768_mortality/aging0.52221398
121MP0000759_abnormal_skeletal_muscle0.51865001
122MP0002082_postnatal_lethality0.48839670
123MP0010770_preweaning_lethality0.48839670
124MP0003956_abnormal_body_size0.46609891
125MP0004185_abnormal_adipocyte_glucose0.46309672
126MP0002752_abnormal_somatic_nervous0.45545418

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.81163146
2Focal motor seizures (HP:0011153)5.47909538
3Visual hallucinations (HP:0002367)4.93937047
4Focal seizures (HP:0007359)4.73363411
5Action tremor (HP:0002345)3.87166510
6Ankle clonus (HP:0011448)3.80882356
7Abnormality of the lower motor neuron (HP:0002366)3.78406776
8Supranuclear gaze palsy (HP:0000605)3.64219465
9Epileptic encephalopathy (HP:0200134)3.48769553
10Poor eye contact (HP:0000817)3.39049247
11Papilledema (HP:0001085)3.37907352
12Progressive cerebellar ataxia (HP:0002073)3.33567211
13Impaired vibration sensation in the lower limbs (HP:0002166)3.29020330
14Depression (HP:0000716)3.28032203
15Tetraplegia (HP:0002445)3.24973189
16Abnormal social behavior (HP:0012433)3.15939990
17Impaired social interactions (HP:0000735)3.15939990
18Urinary bladder sphincter dysfunction (HP:0002839)3.15692922
19Absence seizures (HP:0002121)3.10700309
20Generalized tonic-clonic seizures (HP:0002069)3.10422885
21Atonic seizures (HP:0010819)3.10164466
22Mutism (HP:0002300)3.08559675
23Postural instability (HP:0002172)3.02899488
24Torticollis (HP:0000473)2.96261302
25Insomnia (HP:0100785)2.92848229
26Urinary urgency (HP:0000012)2.92432497
27Annular pancreas (HP:0001734)2.91965263
28Febrile seizures (HP:0002373)2.90964508
29Dysdiadochokinesis (HP:0002075)2.89698831
30Delusions (HP:0000746)2.85710813
31Broad-based gait (HP:0002136)2.80900866
32Ventricular fibrillation (HP:0001663)2.80737577
33Dialeptic seizures (HP:0011146)2.74665630
34Genetic anticipation (HP:0003743)2.71489410
35Anxiety (HP:0000739)2.70341629
36Bundle branch block (HP:0011710)2.70056063
37Hemiplegia (HP:0002301)2.69172410
38Dysmetria (HP:0001310)2.67613007
39Pointed chin (HP:0000307)2.67013615
40Akinesia (HP:0002304)2.66758768
41Focal dystonia (HP:0004373)2.65487770
42Megalencephaly (HP:0001355)2.64235632
43Dysmetric saccades (HP:0000641)2.63800861
44Cerebral inclusion bodies (HP:0100314)2.62467077
45Intention tremor (HP:0002080)2.57701136
46Gaze-evoked nystagmus (HP:0000640)2.57108348
47Cerebral hypomyelination (HP:0006808)2.55022462
48Obstructive sleep apnea (HP:0002870)2.54746920
49Impaired smooth pursuit (HP:0007772)2.50815269
50Spastic gait (HP:0002064)2.48756903
51Amblyopia (HP:0000646)2.48281880
52Abnormal eating behavior (HP:0100738)2.47287661
53Neurofibrillary tangles (HP:0002185)2.46750867
54Amyotrophic lateral sclerosis (HP:0007354)2.44151355
55Truncal ataxia (HP:0002078)2.43892333
56Craniofacial dystonia (HP:0012179)2.40883687
57Peripheral hypomyelination (HP:0007182)2.40155792
58Sleep apnea (HP:0010535)2.38664473
59Resting tremor (HP:0002322)2.38576731
60Hyperacusis (HP:0010780)2.36748517
61Lower limb amyotrophy (HP:0007210)2.35781808
62Hemiparesis (HP:0001269)2.35358289
63Termporal pattern (HP:0011008)2.35137465
64Insidious onset (HP:0003587)2.35137465
65Stereotypic behavior (HP:0000733)2.32413644
66Spinal canal stenosis (HP:0003416)2.31435230
67Bradykinesia (HP:0002067)2.30029142
68Cerebral aneurysm (HP:0004944)2.26406490
69Stridor (HP:0010307)2.21303082
70Ankyloglossia (HP:0010296)2.21037620
71Upper limb amyotrophy (HP:0009129)2.20835743
72Distal upper limb amyotrophy (HP:0007149)2.20835743
73Abnormality of ocular smooth pursuit (HP:0000617)2.19963769
74Lower limb muscle weakness (HP:0007340)2.19277426
75Impaired vibratory sensation (HP:0002495)2.17411634
76Achilles tendon contracture (HP:0001771)2.16635402
77Abnormality of binocular vision (HP:0011514)2.15225526
78Diplopia (HP:0000651)2.15225526
79Hand muscle atrophy (HP:0009130)2.13615486
80Clonus (HP:0002169)2.12250069
81Spastic tetraparesis (HP:0001285)2.12008184
82Bronchomalacia (HP:0002780)2.11618420
83Apathy (HP:0000741)2.11592373
84Abnormality of the corticospinal tract (HP:0002492)2.08134945
85Excessive salivation (HP:0003781)2.06733489
86Drooling (HP:0002307)2.06733489
87Rapidly progressive (HP:0003678)2.05636049
88Status epilepticus (HP:0002133)2.02563476
89Abnormality of the Achilles tendon (HP:0005109)1.97993626
90Elfin facies (HP:0004428)1.97581298
91EEG with generalized epileptiform discharges (HP:0011198)1.95905191
92Hypsarrhythmia (HP:0002521)1.94915192
93Neuronal loss in central nervous system (HP:0002529)1.93663170
94Epileptiform EEG discharges (HP:0011182)1.93154874
95Exercise-induced myalgia (HP:0003738)1.91534266
96Scanning speech (HP:0002168)1.90825501
97Dementia (HP:0000726)1.90385910
98Intellectual disability, profound (HP:0002187)1.89505341
99Hyperthyroidism (HP:0000836)1.89245513
100Lower limb asymmetry (HP:0100559)1.88293273
101Neoplasm of the heart (HP:0100544)1.87405665
102Diminished motivation (HP:0000745)1.86022417
103Ocular albinism (HP:0001107)1.85945583
104Abnormal EKG (HP:0003115)1.82905926
105Macroorchidism (HP:0000053)1.82707592
106Hypercortisolism (HP:0001578)1.82698008
107Fetal akinesia sequence (HP:0001989)1.82585463
108Progressive inability to walk (HP:0002505)1.80841592
109Agitation (HP:0000713)1.79856147
110Truncus arteriosus (HP:0001660)1.79479498
111Distal sensory impairment (HP:0002936)1.79040701
112Abnormality of the periventricular white matter (HP:0002518)1.77935043
113Heart block (HP:0012722)1.77575429
114Overriding aorta (HP:0002623)1.76019606
115Inappropriate behavior (HP:0000719)1.75764398
116Limb dystonia (HP:0002451)1.74423739
117Abnormal atrioventricular conduction (HP:0005150)1.74327958
118Bowel incontinence (HP:0002607)1.74040305
119Turricephaly (HP:0000262)1.72989938
120Choreoathetosis (HP:0001266)1.72977199
121Rigidity (HP:0002063)1.72805289
122Aplasia involving bones of the extremities (HP:0009825)1.72059182
123Aplasia involving bones of the upper limbs (HP:0009823)1.72059182
124Aplasia of the phalanges of the hand (HP:0009802)1.72059182
125Shallow orbits (HP:0000586)1.71595566
126Nuclear cataract (HP:0100018)1.70792803
127Thickened helices (HP:0000391)1.69825116
128Slow progression (HP:0003677)1.69520476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.13185214
2EPHA44.07964476
3NTRK33.47960266
4MARK13.39317060
5PRKD33.18416629
6DAPK22.85713308
7PAK62.63085620
8MINK12.54185029
9KSR22.45985873
10MAP3K42.44741458
11CAMKK12.37253339
12NTRK12.04427682
13NTRK21.98946269
14TRIB31.77070438
15TYRO31.75886791
16TAOK11.72229192
17STK381.64106242
18MAP2K41.55698993
19LATS21.55639772
20RIPK11.53091280
21CDK51.51864129
22KSR11.51727904
23MAP2K71.49570554
24SIK21.45591495
25PHKG21.45234516
26PHKG11.45234516
27DAPK11.41652572
28MAP3K21.34481022
29ALK1.30807073
30UHMK11.15855012
31ICK1.13764062
32PRKCH1.13465745
33MAP3K111.11822143
34STK111.10644062
35RET1.09732170
36PKN21.09241203
37RIPK41.06074783
38TESK11.03931350
39GRK51.01536187
40SMG10.99505044
41PRKCG0.98372359
42PRPF4B0.97584052
43LMTK20.95870866
44NEK10.95027335
45MARK20.93139799
46PINK10.92241901
47CDK150.91232319
48SIK10.90621279
49FES0.89291829
50PDGFRA0.89261967
51CAMK10.88280527
52CDK180.87721518
53CDK140.84282778
54PKN10.84137348
55NEK60.83485060
56MAPK130.82084874
57PAK30.81957167
58CAMKK20.81082628
59BRAF0.80788470
60ARAF0.80774305
61CDK11A0.79351134
62SCYL20.78827792
63MAP3K130.78195104
64IRAK20.77622218
65DDR20.77432017
66PDK10.75612950
67MAP3K70.74617760
68TAOK20.74447450
69PLK20.73455808
70CAMK2G0.73179440
71CDK190.70728590
72PDPK10.70517046
73SGK30.70201231
74IRAK30.68736169
75RAF10.68583238
76DMPK0.67504407
77SGK2230.65001099
78SGK4940.65001099
79MAP3K10.64456758
80MAP2K60.64025139
81BMX0.62790939
82CDC42BPA0.62775298
83PTK2B0.60970607
84CAMK2A0.60763179
85BRSK10.59826828
86SGK10.59748915
87PRKCZ0.58317029
88CAMK1G0.58231676
89PRKG20.57532234
90DAPK30.57260385
91RPS6KA30.54549765
92CAMK40.52662559
93CSNK1G20.52620057
94LIMK10.51354104
95PNCK0.50447561
96FYN0.48166095
97RPS6KA20.47959491
98PRKD20.44018445
99PDK30.43858604
100PDK40.43858604
101MAPK100.43836263
102TNK20.42727929
103MAP3K120.42658457
104FGFR20.42501800
105MAP2K10.41963074
106ROCK10.41789759
107DYRK1A0.41718091
108SGK20.41459057
109MAP3K60.41205921
110ROCK20.40670185
111MAPK40.39524373
112CASK0.39023175
113WNK10.38518075
114HIPK20.38052961
115CAMK1D0.37761854
116ERN10.36920377
117EEF2K0.35368419
118CAMK2B0.34631407
119TNIK0.33785642
120MAPK120.33028372
121MAPK80.30463043
122PRKD10.30204840

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.87807723
2Olfactory transduction_Homo sapiens_hsa047402.67136035
3Nicotine addiction_Homo sapiens_hsa050332.60104820
4Circadian entrainment_Homo sapiens_hsa047132.42882542
5Long-term potentiation_Homo sapiens_hsa047202.41002498
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38971615
7GABAergic synapse_Homo sapiens_hsa047272.33258871
8Glutamatergic synapse_Homo sapiens_hsa047242.27909980
9Amphetamine addiction_Homo sapiens_hsa050312.16089058
10Morphine addiction_Homo sapiens_hsa050322.12230980
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09748135
12Dopaminergic synapse_Homo sapiens_hsa047281.98092402
13Nitrogen metabolism_Homo sapiens_hsa009101.96790164
14Salivary secretion_Homo sapiens_hsa049701.96249455
15Insulin secretion_Homo sapiens_hsa049111.91619839
16Gastric acid secretion_Homo sapiens_hsa049711.89791224
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87605241
18Cholinergic synapse_Homo sapiens_hsa047251.86375219
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83104399
20Vitamin B6 metabolism_Homo sapiens_hsa007501.76935720
21Oxytocin signaling pathway_Homo sapiens_hsa049211.65760529
22Cocaine addiction_Homo sapiens_hsa050301.57344964
23Renin secretion_Homo sapiens_hsa049241.53555867
24GnRH signaling pathway_Homo sapiens_hsa049121.50814412
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50501444
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44964062
27Type II diabetes mellitus_Homo sapiens_hsa049301.42611187
28Glioma_Homo sapiens_hsa052141.42009595
29Gap junction_Homo sapiens_hsa045401.41967172
30Long-term depression_Homo sapiens_hsa047301.40140883
31Calcium signaling pathway_Homo sapiens_hsa040201.35551529
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34756158
33Estrogen signaling pathway_Homo sapiens_hsa049151.31164398
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23789728
35Taste transduction_Homo sapiens_hsa047421.21675934
36cAMP signaling pathway_Homo sapiens_hsa040241.20822172
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17388701
38Serotonergic synapse_Homo sapiens_hsa047261.12136341
39ErbB signaling pathway_Homo sapiens_hsa040121.09981573
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09536847
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08059740
42Melanogenesis_Homo sapiens_hsa049161.07934753
43Axon guidance_Homo sapiens_hsa043601.07927872
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98763045
45mTOR signaling pathway_Homo sapiens_hsa041500.98374940
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.98069556
47Dilated cardiomyopathy_Homo sapiens_hsa054140.95213639
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93696917
49VEGF signaling pathway_Homo sapiens_hsa043700.92198736
50Oocyte meiosis_Homo sapiens_hsa041140.90147577
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.89263530
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88973882
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.87860157
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86924951
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85441679
56Thyroid hormone synthesis_Homo sapiens_hsa049180.80082348
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79624301
58Bile secretion_Homo sapiens_hsa049760.78556232
59Endometrial cancer_Homo sapiens_hsa052130.78456444
60Pancreatic secretion_Homo sapiens_hsa049720.77132672
61Glucagon signaling pathway_Homo sapiens_hsa049220.76919874
62Non-small cell lung cancer_Homo sapiens_hsa052230.74808677
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74745977
64MAPK signaling pathway_Homo sapiens_hsa040100.74045575
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73927924
66Choline metabolism in cancer_Homo sapiens_hsa052310.73702325
67Cardiac muscle contraction_Homo sapiens_hsa042600.73240645
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71498501
69Insulin signaling pathway_Homo sapiens_hsa049100.68815127
70Endocytosis_Homo sapiens_hsa041440.68483216
71Rap1 signaling pathway_Homo sapiens_hsa040150.66208218
72Notch signaling pathway_Homo sapiens_hsa043300.65323377
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64528188
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62806175
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62602331
76Renal cell carcinoma_Homo sapiens_hsa052110.62108935
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61352203
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.57200438
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.55501218
80Ras signaling pathway_Homo sapiens_hsa040140.54606248
81Collecting duct acid secretion_Homo sapiens_hsa049660.54046739
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51674853
83Chronic myeloid leukemia_Homo sapiens_hsa052200.51602760
84Prion diseases_Homo sapiens_hsa050200.50638469
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50178585
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49600283
87Alcoholism_Homo sapiens_hsa050340.48819926
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46997509
89Arginine biosynthesis_Homo sapiens_hsa002200.46488727
90B cell receptor signaling pathway_Homo sapiens_hsa046620.45940084
91HIF-1 signaling pathway_Homo sapiens_hsa040660.45131905
92Inositol phosphate metabolism_Homo sapiens_hsa005620.44983567
93Wnt signaling pathway_Homo sapiens_hsa043100.44035705
94Colorectal cancer_Homo sapiens_hsa052100.43992622
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43894755
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43841005
97Arginine and proline metabolism_Homo sapiens_hsa003300.42388242
98AMPK signaling pathway_Homo sapiens_hsa041520.41591856
99Circadian rhythm_Homo sapiens_hsa047100.40984746
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40476754
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40335382
102Prolactin signaling pathway_Homo sapiens_hsa049170.40327134
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40224965
104Fatty acid biosynthesis_Homo sapiens_hsa000610.39611272
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39496982
106Acute myeloid leukemia_Homo sapiens_hsa052210.38255186
107Tight junction_Homo sapiens_hsa045300.38244475
108Chemokine signaling pathway_Homo sapiens_hsa040620.38203819
109Vibrio cholerae infection_Homo sapiens_hsa051100.37208622
110Platelet activation_Homo sapiens_hsa046110.36560916
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.35735152
112Insulin resistance_Homo sapiens_hsa049310.35193980
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34726746
114Focal adhesion_Homo sapiens_hsa045100.33623618

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