MAP2K1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.43456757
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17344157
3synaptic vesicle exocytosis (GO:0016079)5.77032758
4locomotory exploration behavior (GO:0035641)5.69382995
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.58181883
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34319443
7glutamate secretion (GO:0014047)5.28428658
8regulation of synaptic vesicle exocytosis (GO:2000300)5.06112788
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.83978092
10regulation of synaptic vesicle transport (GO:1902803)4.68155775
11regulation of neuronal synaptic plasticity (GO:0048168)4.62637083
12vocalization behavior (GO:0071625)4.60466580
13regulation of glutamate receptor signaling pathway (GO:1900449)4.59236697
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.58636798
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56324746
16regulation of synapse structural plasticity (GO:0051823)4.54022384
17protein localization to endosome (GO:0036010)4.53512492
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.36530917
19neuronal action potential propagation (GO:0019227)4.34748929
20exploration behavior (GO:0035640)4.32812143
21neurotransmitter secretion (GO:0007269)4.29662412
22cellular potassium ion homeostasis (GO:0030007)4.19976892
23protein localization to synapse (GO:0035418)4.14409698
24L-amino acid import (GO:0043092)4.13243752
25glutamate receptor signaling pathway (GO:0007215)3.99141460
26sodium ion export (GO:0071436)3.93885840
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.93400210
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88208924
29regulation of dendritic spine morphogenesis (GO:0061001)3.86908965
30amino acid import (GO:0043090)3.86643721
31regulation of synaptic plasticity (GO:0048167)3.84313811
32synaptic transmission, glutamatergic (GO:0035249)3.83633830
33layer formation in cerebral cortex (GO:0021819)3.82849184
34long-term memory (GO:0007616)3.80817973
35activation of protein kinase A activity (GO:0034199)3.76975139
36neuron-neuron synaptic transmission (GO:0007270)3.76352678
37proline transport (GO:0015824)3.74608267
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.74260705
39neuromuscular process controlling posture (GO:0050884)3.73827307
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65500319
41neuromuscular process controlling balance (GO:0050885)3.63464520
42positive regulation of membrane potential (GO:0045838)3.61269770
43long-term synaptic potentiation (GO:0060291)3.58085356
44synaptic vesicle endocytosis (GO:0048488)3.57749288
45prepulse inhibition (GO:0060134)3.53655897
46regulation of postsynaptic membrane potential (GO:0060078)3.48786727
47regulation of vesicle fusion (GO:0031338)3.47747848
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.43926910
49positive regulation of synapse maturation (GO:0090129)3.42792914
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42683117
51neuron cell-cell adhesion (GO:0007158)3.42058750
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.41319345
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.39237979
54behavioral defense response (GO:0002209)3.37688201
55behavioral fear response (GO:0001662)3.37688201
56neurotransmitter transport (GO:0006836)3.36188434
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35348315
58* regulation of early endosome to late endosome transport (GO:2000641)3.33683465
59negative regulation of amino acid transport (GO:0051956)3.33649017
60regulation of glutamate secretion (GO:0014048)3.33388354
61stress fiber assembly (GO:0043149)3.32407727
62dendritic spine morphogenesis (GO:0060997)3.31795020
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.28933985
64neurotransmitter-gated ion channel clustering (GO:0072578)3.28861300
65focal adhesion assembly (GO:0048041)3.28627953
66cell-substrate adherens junction assembly (GO:0007045)3.28627953
67regulation of neurotransmitter levels (GO:0001505)3.26892064
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25116330
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24940521
70mating behavior (GO:0007617)3.24730390
71regulation of clathrin-mediated endocytosis (GO:2000369)3.23319779
72synaptic transmission, dopaminergic (GO:0001963)3.20830884
73response to histamine (GO:0034776)3.18527050
74positive regulation of vesicle fusion (GO:0031340)3.12949690
75adherens junction assembly (GO:0034333)3.12920026
76activation of Rac GTPase activity (GO:0032863)3.12783199
77gamma-aminobutyric acid transport (GO:0015812)3.11381452
78regulation of neurotransmitter secretion (GO:0046928)3.09760221
79behavioral response to cocaine (GO:0048148)3.09706983
80regulation of dendritic spine development (GO:0060998)3.08776192
81fear response (GO:0042596)3.08680317
82dendritic spine organization (GO:0097061)3.07970628
83long term synaptic depression (GO:0060292)3.07237670
84positive regulation of neurotransmitter transport (GO:0051590)3.06658884
85* vesicle transport along microtubule (GO:0047496)3.06502855
86cell communication by electrical coupling (GO:0010644)3.05955662
87positive regulation of neurotransmitter secretion (GO:0001956)3.05901079
88regulation of ARF protein signal transduction (GO:0032012)3.04056135
89positive regulation of synaptic transmission (GO:0050806)3.03386157
90signal complex assembly (GO:0007172)3.02665905
91cerebellar granule cell differentiation (GO:0021707)3.02581728
92regulation of neurotransmitter transport (GO:0051588)3.01800824
93cortical actin cytoskeleton organization (GO:0030866)3.00541757
94transmission of nerve impulse (GO:0019226)3.00440112
95negative regulation of erythrocyte differentiation (GO:0045647)2.99935675
96positive regulation of fibroblast migration (GO:0010763)2.99516729
97regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.98417872
98regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.98417872
99barbed-end actin filament capping (GO:0051016)2.98231539
100regulation of synaptic transmission (GO:0050804)2.97560560
101cell-substrate junction assembly (GO:0007044)2.95329986
102regulation of voltage-gated calcium channel activity (GO:1901385)2.92273756
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91817372
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91630356
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90285555
106negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.89325686
107activation of MAPKKK activity (GO:0000185)2.89125990
108synaptic vesicle transport (GO:0048489)2.88790043
109establishment of synaptic vesicle localization (GO:0097480)2.88790043
110cellular sodium ion homeostasis (GO:0006883)2.88499384
111negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88354439
112membrane depolarization (GO:0051899)2.87665350
113regulation of NFAT protein import into nucleus (GO:0051532)2.86913124
114regulation of synaptic transmission, dopaminergic (GO:0032225)2.86459119
115neuron recognition (GO:0008038)2.85756354
116synaptic transmission (GO:0007268)2.85673474
117neuromuscular process (GO:0050905)2.85593824
118mitotic chromosome condensation (GO:0007076)2.85433442
119regulation of amyloid precursor protein catabolic process (GO:1902991)2.83814197
120positive regulation of protein dephosphorylation (GO:0035307)2.82120529
121dopamine receptor signaling pathway (GO:0007212)2.81937639
122response to peptidoglycan (GO:0032494)2.81317895
123cellular protein complex localization (GO:0034629)2.73894100
124positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.65714301
125positive regulation of Rap GTPase activity (GO:0032854)2.64776230
126regulation of T-helper 2 cell differentiation (GO:0045628)2.64271790
127regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.62783582
128positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.62783582
129cortical cytoskeleton organization (GO:0030865)2.58981644
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51576834
131glucocorticoid receptor signaling pathway (GO:0042921)2.50539412
132negative regulation of toll-like receptor signaling pathway (GO:0034122)2.49216029
133positive regulation of macrophage cytokine production (GO:0060907)2.46745109
134positive regulation by symbiont of host defense response (GO:0052509)2.44156673
135modulation by symbiont of host defense response (GO:0052031)2.44156673
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44156673
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44156673
138positive regulation by organism of defense response of other organism involved in symbiotic interact2.44156673
139modulation by symbiont of host immune response (GO:0052553)2.44156673
140response to laminar fluid shear stress (GO:0034616)2.43818606
141hypotonic response (GO:0006971)2.43380212
142response to muramyl dipeptide (GO:0032495)2.40813629
143pinocytosis (GO:0006907)2.39500439
144negative regulation of cell killing (GO:0031342)2.38375020
145negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38375020
146positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37960115
147hemidesmosome assembly (GO:0031581)2.36435910
148membrane raft organization (GO:0031579)2.34961672
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.34912629
150Golgi transport vesicle coating (GO:0048200)2.33793512
151COPI coating of Golgi vesicle (GO:0048205)2.33793512
152positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33394307
153modulation by symbiont of host cellular process (GO:0044068)2.32473261
154corticosteroid receptor signaling pathway (GO:0031958)2.32371651
155negative regulation of skeletal muscle tissue development (GO:0048642)2.32249924
156adenosine receptor signaling pathway (GO:0001973)2.31954546
157negative regulation of dendrite morphogenesis (GO:0050774)2.31734833
158macrophage activation involved in immune response (GO:0002281)2.31717412
159positive regulation of gamma-delta T cell activation (GO:0046645)2.28380315
160retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.28095945
161potassium ion homeostasis (GO:0055075)2.27644119
162peptidyl-threonine phosphorylation (GO:0018107)2.27046995
163peptidyl-proline hydroxylation (GO:0019511)2.26829484
164peptidyl-threonine modification (GO:0018210)2.26055643
165regulation of defense response to virus by virus (GO:0050690)2.25390559
166positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25067855
167positive regulation of cellular amide metabolic process (GO:0034250)2.24758840
168regulation of ARF GTPase activity (GO:0032312)2.22876422
169protein retention in ER lumen (GO:0006621)2.22403060
170regulation of macrophage cytokine production (GO:0010935)2.20811599
171regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.19384704
172regulation of protein dephosphorylation (GO:0035304)2.19325327
173regulation of glucocorticoid metabolic process (GO:0031943)2.19100331
174endocytic recycling (GO:0032456)2.17337295
175positive regulation of protein export from nucleus (GO:0046827)2.16805992
176protein complex localization (GO:0031503)2.15538734
177epithelial cell differentiation involved in prostate gland development (GO:0060742)2.15488003
178actin filament bundle organization (GO:0061572)2.15395689
179actin filament bundle assembly (GO:0051017)2.15395689
180positive regulation of receptor recycling (GO:0001921)2.15387925
181regulation of Rap GTPase activity (GO:0032317)2.15308088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29188706
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.48210389
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.40175358
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00179306
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99539270
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.85626274
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79117528
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.77096730
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.71126937
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62504390
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61610191
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61610191
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61026478
14GBX2_23144817_ChIP-Seq_PC3_Human2.60646823
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59203944
16MYC_22102868_ChIP-Seq_BL_Human2.53199675
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.49035179
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48949874
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45440920
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.45392698
21DROSHA_22980978_ChIP-Seq_HELA_Human2.41755950
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29744604
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28529927
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.22851931
25LXR_22292898_ChIP-Seq_THP-1_Human2.20014844
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19635128
27VDR_21846776_ChIP-Seq_THP-1_Human2.14946425
28TCF7_22412390_ChIP-Seq_EML_Mouse2.13887106
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11931057
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09574427
31CLOCK_20551151_ChIP-Seq_293T_Human2.06143739
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.05089009
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.98569696
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.97812145
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.92545569
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90870725
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88274452
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.85572695
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84131550
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75706270
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.75374240
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75121094
43RACK7_27058665_Chip-Seq_MCF-7_Human1.74277955
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.69013264
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63297336
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62539308
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59860913
48* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58611215
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58119947
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57909539
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57658626
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55599658
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55248659
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55113426
55* KDM2B_26808549_Chip-Seq_JURKAT_Human1.54988662
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54389923
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53978231
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52788902
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51109173
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51102034
61VDR_24763502_ChIP-Seq_THP-1_Human1.50618258
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46384745
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46076037
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45638603
65AR_21572438_ChIP-Seq_LNCaP_Human1.45623848
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45594631
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44060439
68KDM2B_26808549_Chip-Seq_K562_Human1.42999794
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.41140985
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40399701
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39633648
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39212829
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36269723
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35532145
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34891576
76MAF_26560356_Chip-Seq_TH1_Human1.34269032
77* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34087015
78ATF3_27146783_Chip-Seq_COLON_Human1.32904606
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31156868
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.31065871
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31010874
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29403753
83* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28865886
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.27786569
85* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27094086
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26772278
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26434493
88GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.24840694
89ZNF263_19887448_ChIP-Seq_K562_Human1.24582551
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23814800
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23749930
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23621093
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22520402
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21246446
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20306461
96TP53_16413492_ChIP-PET_HCT116_Human1.18400406
97ZNF274_21170338_ChIP-Seq_K562_Hela1.18159342
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.18103787
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17729640
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15712169
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14717367
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14457983
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14146699
104* AR_19668381_ChIP-Seq_PC3_Human1.14002604
105RXR_22108803_ChIP-Seq_LS180_Human1.13454988
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13021825
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12756491
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12735126
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.12301539
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.12301539
111AR_25329375_ChIP-Seq_VCAP_Human1.10986201
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10321653
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10162185
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10162185
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10162185
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10052822
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09601663
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07293269
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07277740
120SPI1_23127762_ChIP-Seq_K562_Human1.06467918
121TET1_21490601_ChIP-Seq_MESCs_Mouse1.05486056
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05030472
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04590581
124* IRF8_27001747_Chip-Seq_BMDM_Mouse1.03959814
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03615561
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.03076802
127TAF15_26573619_Chip-Seq_HEK293_Human1.02945160
128* STAT3_23295773_ChIP-Seq_U87_Human1.02424336
129MAF_26560356_Chip-Seq_TH2_Human1.01942426
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01798622
131ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01620853
132HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01002126
133TRIM28_21343339_ChIP-Seq_HEK293_Human1.00201530
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99988871
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99131135
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98897617
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98708389
138NCOR1_26117541_ChIP-Seq_K562_Human0.98704623
139SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98339975
140STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98095263
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97947020
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97044601
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96786882
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.96521404
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96479242
146ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95863257
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.95425244
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.94620754
149P300_19829295_ChIP-Seq_ESCs_Human0.94312730
150RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93436696
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92925893
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92920833
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92697633
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.92525132
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.92360691
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91289648
157SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90782478
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.90543142
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87937143
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87821781
161KLF4_19829295_ChIP-Seq_ESCs_Human0.87551065
162TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86608291
163GATA1_26923725_Chip-Seq_HPCs_Mouse0.85905353
164* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85362728
165* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84682385
166KDM2B_26808549_Chip-Seq_DND41_Human0.83748344
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83520786
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.82763305
169ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82494712
170JUN_21703547_ChIP-Seq_K562_Human0.82399668
171DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82178012
172CTCF_27219007_Chip-Seq_Bcells_Human0.81629586
173ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81397584
174* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80552345
175TCF4_23295773_ChIP-Seq_U87_Human0.78970803
176* SMAD4_21741376_ChIP-Seq_EPCs_Human0.78389700
177AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77301473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.53679380
2MP0003880_abnormal_central_pattern4.89918496
3MP0003705_abnormal_hypodermis_morpholog4.33035741
4MP0003635_abnormal_synaptic_transmissio4.32586074
5MP0004270_analgesia3.76965548
6MP0002822_catalepsy3.63681747
7MP0009745_abnormal_behavioral_response3.50688218
8MP0002063_abnormal_learning/memory/cond3.44708203
9MP0002064_seizures3.24362958
10MP0002877_abnormal_melanocyte_morpholog3.08386759
11MP0005451_abnormal_body_composition3.05636294
12MP0001968_abnormal_touch/_nociception2.98405820
13MP0009046_muscle_twitch2.92631200
14MP0003329_amyloid_beta_deposits2.78094664
15MP0002572_abnormal_emotion/affect_behav2.69604241
16MP0001501_abnormal_sleep_pattern2.65647549
17MP0002272_abnormal_nervous_system2.47869376
18MP0003566_abnormal_cell_adhesion2.43178595
19MP0002736_abnormal_nociception_after2.40360767
20MP0002734_abnormal_mechanical_nocicepti2.30990074
21MP0003300_gastrointestinal_ulcer2.25174144
22MP0001440_abnormal_grooming_behavior2.23757372
23MP0001486_abnormal_startle_reflex2.22367693
24MP0004858_abnormal_nervous_system2.15701141
25MP0001849_ear_inflammation2.10021067
26MP0008260_abnormal_autophagy2.06599403
27MP0002909_abnormal_adrenal_gland1.98576732
28* MP0003091_abnormal_cell_migration1.97037621
29MP0002733_abnormal_thermal_nociception1.96678180
30MP0005076_abnormal_cell_differentiation1.91446336
31MP0001970_abnormal_pain_threshold1.87801018
32MP0002735_abnormal_chemical_nociception1.86259742
33MP0005423_abnormal_somatic_nervous1.79922850
34MP0003436_decreased_susceptibility_to1.78578803
35MP0003828_pulmonary_edema1.77606322
36MP0004924_abnormal_behavior1.74662609
37MP0005386_behavior/neurological_phenoty1.74662609
38MP0004185_abnormal_adipocyte_glucose1.74403386
39MP0000604_amyloidosis1.74281182
40MP0003075_altered_response_to1.72453600
41MP0004947_skin_inflammation1.69220372
42MP0005409_darkened_coat_color1.68859745
43MP0004811_abnormal_neuron_physiology1.68816675
44MP0003879_abnormal_hair_cell1.68153416
45MP0002067_abnormal_sensory_capabilities1.66952609
46MP0004510_myositis1.65411186
47MP0010352_gastrointestinal_tract_polyps1.65256395
48MP0001529_abnormal_vocalization1.60322573
49MP0009840_abnormal_foam_cell1.60164331
50MP0000858_altered_metastatic_potential1.57064406
51* MP0003453_abnormal_keratinocyte_physiol1.55079042
52MP0008569_lethality_at_weaning1.54968093
53MP0005666_abnormal_adipose_tissue1.51673047
54MP0008438_abnormal_cutaneous_collagen1.46807022
55MP0000013_abnormal_adipose_tissue1.46403951
56MP0001905_abnormal_dopamine_level1.46344057
57MP0002184_abnormal_innervation1.42633313
58MP0003191_abnormal_cellular_cholesterol1.40107099
59MP0005023_abnormal_wound_healing1.37189561
60MP0004272_abnormal_basement_membrane1.36142477
61MP0000955_abnormal_spinal_cord1.35914211
62MP0005375_adipose_tissue_phenotype1.35116618
63MP0002066_abnormal_motor_capabilities/c1.34586712
64MP0002557_abnormal_social/conspecific_i1.34148098
65MP0003633_abnormal_nervous_system1.32767142
66MP0004885_abnormal_endolymph1.29660864
67MP0002998_abnormal_bone_remodeling1.28236912
68MP0009780_abnormal_chondrocyte_physiolo1.27880002
69MP0008874_decreased_physiological_sensi1.26878133
70MP0000759_abnormal_skeletal_muscle1.26206792
71MP0000733_abnormal_muscle_development1.24153423
72MP0004087_abnormal_muscle_fiber1.24020649
73MP0001502_abnormal_circadian_rhythm1.18125686
74MP0002419_abnormal_innate_immunity1.17278684
75MP0005000_abnormal_immune_tolerance1.16498361
76MP0006276_abnormal_autonomic_nervous1.16433939
77MP0003631_nervous_system_phenotype1.16021372
78* MP0005621_abnormal_cell_physiology1.15800812
79MP0002882_abnormal_neuron_morphology1.14975303
80MP0000003_abnormal_adipose_tissue1.12478797
81MP0003448_altered_tumor_morphology1.12270548
82MP0005167_abnormal_blood-brain_barrier1.11430898
83MP0001730_embryonic_growth_arrest1.11315780
84MP0000778_abnormal_nervous_system1.10591905
85MP0002837_dystrophic_cardiac_calcinosis1.10249015
86MP0008872_abnormal_physiological_respon1.09358463
87MP0003950_abnormal_plasma_membrane1.08102520
88MP0004142_abnormal_muscle_tone1.07398212
89MP0003123_paternal_imprinting1.07276490
90MP0001853_heart_inflammation1.06749763
91MP0003172_abnormal_lysosome_physiology1.05743805
92MP0000685_abnormal_immune_system1.05056907
93MP0008961_abnormal_basal_metabolism1.03753444
94MP0003690_abnormal_glial_cell1.02545133
95MP0001915_intracranial_hemorrhage1.01884950
96MP0000343_altered_response_to1.01047827
97MP0003787_abnormal_imprinting0.99971008
98MP0000678_abnormal_parathyroid_gland0.99428226
99MP0005535_abnormal_body_temperature0.99125482
100MP0002089_abnormal_postnatal_growth/wei0.96541596
101MP0000350_abnormal_cell_proliferation0.96478206
102MP0000751_myopathy0.96377687
103MP0009278_abnormal_bone_marrow0.96294423
104MP0001851_eye_inflammation0.93421785
105MP0005257_abnormal_intraocular_pressure0.93401770
106MP0005623_abnormal_meninges_morphology0.93315203
107MP0004233_abnormal_muscle_weight0.92788277
108MP0004145_abnormal_muscle_electrophysio0.91848330
109MP0003632_abnormal_nervous_system0.91654240
110MP0002090_abnormal_vision0.91541214
111MP0002152_abnormal_brain_morphology0.88893934
112MP0000920_abnormal_myelination0.88163730
113MP0010368_abnormal_lymphatic_system0.88033889
114MP0010386_abnormal_urinary_bladder0.87849204
115MP0002229_neurodegeneration0.87758074
116MP0010630_abnormal_cardiac_muscle0.87669129
117MP0005464_abnormal_platelet_physiology0.87553801
118MP0001790_abnormal_immune_system0.86840242
119MP0005387_immune_system_phenotype0.86840242
120MP0003303_peritoneal_inflammation0.86798452
121MP0005646_abnormal_pituitary_gland0.86360451
122MP0005165_increased_susceptibility_to0.86096525
123MP0002069_abnormal_eating/drinking_beha0.84749542
124MP0003634_abnormal_glial_cell0.84412773
125MP0001984_abnormal_olfaction0.84360448
126* MP0002796_impaired_skin_barrier0.83892206
127MP0002452_abnormal_antigen_presenting0.83814250
128MP0003283_abnormal_digestive_organ0.82255657
129MP0000749_muscle_degeneration0.82163890
130MP0000747_muscle_weakness0.81687460
131MP0003646_muscle_fatigue0.80563743
132MP0003763_abnormal_thymus_physiology0.79534554
133MP0005025_abnormal_response_to0.79273707
134MP0005166_decreased_susceptibility_to0.78254723
135MP0002420_abnormal_adaptive_immunity0.77646364
136MP0001819_abnormal_immune_cell0.76638615
137MP0002060_abnormal_skin_morphology0.75922205
138MP0008004_abnormal_stomach_pH0.75223323
139MP0000579_abnormal_nail_morphology0.75213758
140MP0006082_CNS_inflammation0.74550443
141MP0002723_abnormal_immune_serum0.74290062
142* MP0005384_cellular_phenotype0.73952474
143MP0003279_aneurysm0.73786758
144MP0002148_abnormal_hypersensitivity_rea0.73450106
145MP0005310_abnormal_salivary_gland0.73355919
146MP0001177_atelectasis0.73314769
147MP0000750_abnormal_muscle_regeneration0.70980295
148MP0004484_altered_response_of0.69860194
149MP0003122_maternal_imprinting0.66816175
150MP0004085_abnormal_heartbeat0.66414811
151MP0004130_abnormal_muscle_cell0.62977617
152MP0005058_abnormal_lysosome_morphology0.62181581
153MP0000569_abnormal_digit_pigmentation0.59333042
154MP0002653_abnormal_ependyma_morphology0.55657161
155MP0003183_abnormal_peptide_metabolism0.55283599
156MP0001664_abnormal_digestion0.54913116
157MP0002269_muscular_atrophy0.54700025
158MP0004036_abnormal_muscle_relaxation0.53090828
159MP0001765_abnormal_ion_homeostasis0.52168819
160MP0002332_abnormal_exercise_endurance0.51241557
161MP0004215_abnormal_myocardial_fiber0.50581835
162MP0001485_abnormal_pinna_reflex0.50465596
163MP0001348_abnormal_lacrimal_gland0.49883736
164MP0001963_abnormal_hearing_physiology0.49294276
165MP0003045_fibrosis0.48947166
166MP0005645_abnormal_hypothalamus_physiol0.45952524
167MP0004742_abnormal_vestibular_system0.44777527

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.46481958
2Myokymia (HP:0002411)7.33048339
3Visual hallucinations (HP:0002367)5.68355832
4Focal seizures (HP:0007359)5.64495425
5Atonic seizures (HP:0010819)4.45577513
6Absence seizures (HP:0002121)4.24801923
7Supranuclear gaze palsy (HP:0000605)4.07122468
8Epileptic encephalopathy (HP:0200134)4.01962908
9Dialeptic seizures (HP:0011146)3.92467741
10Generalized tonic-clonic seizures (HP:0002069)3.90743207
11Action tremor (HP:0002345)3.89441746
12Cerebral inclusion bodies (HP:0100314)3.78507247
13Neurofibrillary tangles (HP:0002185)3.54060769
14Febrile seizures (HP:0002373)3.34901865
15Depression (HP:0000716)3.34454021
16Impaired vibration sensation in the lower limbs (HP:0002166)3.32651723
17Dysmetria (HP:0001310)3.31296939
18Mutism (HP:0002300)3.30189165
19Papilledema (HP:0001085)3.28036822
20Ankle clonus (HP:0011448)3.24720245
21Progressive cerebellar ataxia (HP:0002073)3.19659242
22Annular pancreas (HP:0001734)3.17370848
23Poor eye contact (HP:0000817)3.15112976
24Postural instability (HP:0002172)3.12731384
25Dysdiadochokinesis (HP:0002075)3.11154520
26Urinary bladder sphincter dysfunction (HP:0002839)3.08133316
27Abnormality of the lower motor neuron (HP:0002366)3.00428329
28Anxiety (HP:0000739)2.97495482
29Torticollis (HP:0000473)2.95185563
30Abnormal social behavior (HP:0012433)2.91010842
31Impaired social interactions (HP:0000735)2.91010842
32Amblyopia (HP:0000646)2.87917279
33Truncal ataxia (HP:0002078)2.81099657
34Obstructive sleep apnea (HP:0002870)2.79136675
35Abnormal eating behavior (HP:0100738)2.79071996
36Urinary urgency (HP:0000012)2.74829810
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.69668751
38Gaze-evoked nystagmus (HP:0000640)2.68755781
39Spastic gait (HP:0002064)2.66887413
40Bradykinesia (HP:0002067)2.66556895
41Resting tremor (HP:0002322)2.61975275
42Focal dystonia (HP:0004373)2.61140524
43Rapidly progressive (HP:0003678)2.59875276
44Intention tremor (HP:0002080)2.58734820
45Axonal loss (HP:0003447)2.57174795
46Broad-based gait (HP:0002136)2.56082450
47Global brain atrophy (HP:0002283)2.55566434
48Dysmetric saccades (HP:0000641)2.55258298
49Termporal pattern (HP:0011008)2.55160523
50Insidious onset (HP:0003587)2.55160523
51Distal lower limb amyotrophy (HP:0008944)2.52260729
52Increased connective tissue (HP:0009025)2.47788181
53Ventricular fibrillation (HP:0001663)2.46914705
54Apathy (HP:0000741)2.46337038
55Neuronal loss in central nervous system (HP:0002529)2.45665929
56Progressive inability to walk (HP:0002505)2.45410478
57Hyperacusis (HP:0010780)2.44650782
58Impaired smooth pursuit (HP:0007772)2.44150054
59Abnormality of skeletal muscle fiber size (HP:0012084)2.43267099
60Insomnia (HP:0100785)2.42086504
61Stereotypic behavior (HP:0000733)2.40041573
62Protrusio acetabuli (HP:0003179)2.39589445
63Craniofacial dystonia (HP:0012179)2.39197966
64Generalized myoclonic seizures (HP:0002123)2.36664843
65Increased variability in muscle fiber diameter (HP:0003557)2.36488633
66Hemiplegia (HP:0002301)2.35283940
67Delusions (HP:0000746)2.32125177
68Hemiparesis (HP:0001269)2.30843518
69Status epilepticus (HP:0002133)2.29266181
70Scanning speech (HP:0002168)2.29220522
71Diminished motivation (HP:0000745)2.27497768
72Gastrointestinal stroma tumor (HP:0100723)2.27440659
73Diplopia (HP:0000651)2.27432709
74Abnormality of binocular vision (HP:0011514)2.27432709
75Ankyloglossia (HP:0010296)2.26435925
76Pointed chin (HP:0000307)2.23236378
77Pheochromocytoma (HP:0002666)2.23236363
78Achilles tendon contracture (HP:0001771)2.23176935
79Cerebral aneurysm (HP:0004944)2.20929553
80Distal lower limb muscle weakness (HP:0009053)2.19558844
81Lower limb muscle weakness (HP:0007340)2.18510920
82Muscle stiffness (HP:0003552)2.18209166
83Rigidity (HP:0002063)2.17254431
84Slow saccadic eye movements (HP:0000514)2.17228643
85Megalencephaly (HP:0001355)2.16202778
86Premature rupture of membranes (HP:0001788)2.15498718
87Exercise-induced myalgia (HP:0003738)2.13180195
88Hyporeflexia of lower limbs (HP:0002600)2.13167603
89Epileptiform EEG discharges (HP:0011182)2.12907569
90Distal upper limb amyotrophy (HP:0007149)2.12358015
91Upper limb amyotrophy (HP:0009129)2.12358015
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11444723
93Arterial tortuosity (HP:0005116)2.10937884
94Abnormality of macrophages (HP:0004311)2.10797728
95Impaired vibratory sensation (HP:0002495)2.08925736
96Abnormality of ocular smooth pursuit (HP:0000617)2.06772391
97EEG with generalized epileptiform discharges (HP:0011198)2.06110422
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05728949
99Fetal akinesia sequence (HP:0001989)2.05632717
100Cellulitis (HP:0100658)2.04937935
101Genetic anticipation (HP:0003743)2.04653354
102Lower limb asymmetry (HP:0100559)2.03774266
103Hyperventilation (HP:0002883)2.03065562
104Drooling (HP:0002307)2.00619724
105Excessive salivation (HP:0003781)2.00619724
106Psychosis (HP:0000709)2.00385209
107Abnormality of the periventricular white matter (HP:0002518)2.00080091
108Bundle branch block (HP:0011710)1.99109705
109Nuclear cataract (HP:0100018)1.98740970
110Foot dorsiflexor weakness (HP:0009027)1.98570768
111Neuroendocrine neoplasm (HP:0100634)1.97961521
112Tetraplegia (HP:0002445)1.97786644
113Abnormality of the Achilles tendon (HP:0005109)1.96701828
114Eczematoid dermatitis (HP:0000976)1.96157291
115Abnormality of oral frenula (HP:0000190)1.94266161
116Incomplete penetrance (HP:0003829)1.94055664
117Hypsarrhythmia (HP:0002521)1.93315178
118Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.90029542
119Abnormal gallbladder physiology (HP:0012438)1.89935900
120Cholecystitis (HP:0001082)1.89935900
121Limb dystonia (HP:0002451)1.89463408
122Spinal rigidity (HP:0003306)1.88342209
123Lower limb amyotrophy (HP:0007210)1.88166404
124Clonus (HP:0002169)1.87841114
125Abnormality of the corticospinal tract (HP:0002492)1.87690280
126EMG: myopathic abnormalities (HP:0003458)1.87032846
127Neoplasm of the peripheral nervous system (HP:0100007)1.86633450
128Gait ataxia (HP:0002066)1.85609404
129Tetraparesis (HP:0002273)1.85041709
130Dementia (HP:0000726)1.84655009
131Abnormality of liposaccharide metabolism (HP:0010968)1.84608416
132Abnormality of glycosphingolipid metabolism (HP:0004343)1.84608416
133Abnormality of glycolipid metabolism (HP:0010969)1.84608416
134Muscle fiber splitting (HP:0003555)1.84070035
135Muscle fiber inclusion bodies (HP:0100299)1.84044983
136Loss of speech (HP:0002371)1.83537035
137Vertebral compression fractures (HP:0002953)1.83534743
138Vascular tortuosity (HP:0004948)1.81682239
139Peripheral hypomyelination (HP:0007182)1.81638066
140Hyperparathyroidism (HP:0000843)1.80850226
141Nemaline bodies (HP:0003798)1.79182985
142Hypercortisolism (HP:0001578)1.78861453
143Abnormality of the salivary glands (HP:0010286)1.78085462
144Type 1 muscle fiber predominance (HP:0003803)1.77775123
145Hammertoe (HP:0001765)1.77253261
146Myocardial infarction (HP:0001658)1.74516466
147Difficulty climbing stairs (HP:0003551)1.74030678
148Distal sensory impairment (HP:0002936)1.73969572
149Polygenic inheritance (HP:0010982)1.73345608
150Atrophic scars (HP:0001075)1.73035230
151Segmental peripheral demyelination/remyelination (HP:0003481)1.72404099
152Abnormality of the foot musculature (HP:0001436)1.72083533
153Shallow orbits (HP:0000586)1.71744555
154Upper motor neuron abnormality (HP:0002127)1.70649444
155Amyloidosis (HP:0011034)1.67729701
156Difficulty running (HP:0009046)1.67688091
157Spinal cord compression (HP:0002176)1.67257988
158Decreased motor nerve conduction velocity (HP:0003431)1.64962464
159Asymmetric septal hypertrophy (HP:0001670)1.62840615
160Thin bony cortex (HP:0002753)1.61983825
161Emphysema (HP:0002097)1.61329375
162Fatigue (HP:0012378)1.60192098
163Progressive external ophthalmoplegia (HP:0000590)1.59705553
164Bowel incontinence (HP:0002607)1.59172005
165Osteolytic defects of the hand bones (HP:0009699)1.58892650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.40052572
2NTRK34.60039880
3RIPK43.42454385
4* KSR23.33832352
5IRAK32.99288059
6PAK62.84398146
7* MAP3K92.66610078
8MAP3K42.62182342
9MINK12.60941710
10NTRK12.50628634
11DAPK22.38947522
12CDK122.29484638
13PRKD32.27723734
14MAP3K122.12607770
15EEF2K2.09070344
16CAMKK12.01798151
17MAP3K21.91400137
18MAP2K41.89980782
19SMG11.85494603
20ERN11.84991794
21ICK1.78922652
22LATS21.68493382
23TAOK11.63792811
24MAP3K141.59487739
25TTN1.58897586
26TYRO31.57044674
27DAPK11.53222324
28PLK21.53207173
29MAP2K71.52276059
30FES1.52126331
31TAOK21.51335103
32* CDK51.49125901
33BMPR21.48126810
34GRK51.42084044
35SIK11.40076093
36RET1.38564432
37NTRK21.35626740
38IRAK21.35046564
39PTK2B1.34798947
40PNCK1.34605214
41STK381.32839528
42CAMKK21.30253055
43STK241.26910581
44CDK191.26133362
45* KSR11.24578479
46NME21.16566182
47FGR1.11383938
48MAP3K31.10625197
49SIK21.07432263
50FGFR41.06949544
51CAMK2A1.05210685
52SCYL21.03756422
53MAP2K31.02876886
54MAPK121.01673282
55MARK11.00381726
56PRPF4B0.98915501
57PAK30.98232684
58ALK0.94790587
59PAK40.94360810
60PRKCG0.93047660
61CSK0.91760901
62NEK60.86976038
63* CDK140.85696085
64NEK10.85539875
65PRKCH0.84882036
66CAMK10.84508249
67STK110.83190029
68CDC42BPA0.81587635
69CAMK2B0.78102798
70TESK10.77924440
71* RAF10.77601285
72* CDK150.76816412
73* CDK180.76596462
74MTOR0.75507082
75IRAK40.75348723
76WNK10.75048920
77MAP3K100.74522205
78PKN20.73339859
79* PDK10.72230003
80TBK10.71649659
81LMTK20.70018793
82PINK10.69856403
83MAP3K60.69747935
84NEK90.69601407
85JAK10.69480100
86FER0.68753742
87MAPK110.68554234
88CSNK1G20.65993119
89* PDPK10.65961186
90TYK20.64469442
91RIPK10.64467048
92* MAP3K10.64010628
93MET0.63542138
94* CDK11A0.63118343
95ZAP700.62788641
96CAMK2G0.61981828
97* MAP2K10.61554123
98EPHB10.60244837
99UHMK10.60056739
100SGK10.59947096
101DMPK0.59575917
102* MAP3K80.58768146
103DAPK30.58717072
104JAK30.57980854
105TRIB30.56959663
106PRKG20.56540044
107SIK30.55969573
108SGK2230.55879625
109SGK4940.55879625
110CAMK2D0.54940057
111MAP4K10.54024607
112PDGFRB0.53500738
113CAMK1G0.51572576
114FYN0.51541101
115BMX0.50107866
116MAPK100.49885659
117MAPK70.49079544
118MARK20.49063958
119PTK60.48094411
120PAK20.47030744
121OXSR10.46873371
122NME10.46691165
123GRK60.46183757
124CDK60.45596965
125PTK20.45575237
126CDK90.45535770
127RPS6KA20.43876375
128LRRK20.43325136
129MAP3K50.42449362
130* RPS6KA30.42246770
131MAP3K70.41816325
132PRKCZ0.41053516
133DDR20.40703442
134MUSK0.39656174
135MAPKAPK50.39434727
136SGK30.39196062
137MAPK130.38501808
138PDGFRA0.38202707
139DYRK1A0.38191911
140ABL20.37658600
141PRKD20.34803178
142ROCK20.34722500
143MAP3K110.33490956
144JAK20.30838178
145PHKG20.30393807
146PHKG10.30393807
147BRSK10.29875224
148PRKCE0.28109430

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.29148747
2Nicotine addiction_Homo sapiens_hsa050333.04854835
3Olfactory transduction_Homo sapiens_hsa047402.70412441
4* Long-term potentiation_Homo sapiens_hsa047202.67653096
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.65528231
6Circadian entrainment_Homo sapiens_hsa047132.49138046
7Amphetamine addiction_Homo sapiens_hsa050312.48752552
8GABAergic synapse_Homo sapiens_hsa047272.44291961
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42271717
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33065067
11Glutamatergic synapse_Homo sapiens_hsa047242.32507452
12Morphine addiction_Homo sapiens_hsa050322.21879983
13Dopaminergic synapse_Homo sapiens_hsa047282.13380766
14Salivary secretion_Homo sapiens_hsa049702.09338952
15Gastric acid secretion_Homo sapiens_hsa049711.87035439
16Insulin secretion_Homo sapiens_hsa049111.81160789
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77164743
18* Cholinergic synapse_Homo sapiens_hsa047251.76168658
19* Oxytocin signaling pathway_Homo sapiens_hsa049211.72435674
20Cocaine addiction_Homo sapiens_hsa050301.66874934
21* GnRH signaling pathway_Homo sapiens_hsa049121.66478707
22Renin secretion_Homo sapiens_hsa049241.64730928
23* B cell receptor signaling pathway_Homo sapiens_hsa046621.64361172
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64087651
25* Long-term depression_Homo sapiens_hsa047301.63166758
26Collecting duct acid secretion_Homo sapiens_hsa049661.52265284
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46307597
28Calcium signaling pathway_Homo sapiens_hsa040201.46198220
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41251283
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40770425
31* Serotonergic synapse_Homo sapiens_hsa047261.38976417
32Nitrogen metabolism_Homo sapiens_hsa009101.37798415
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34771731
34* Chronic myeloid leukemia_Homo sapiens_hsa052201.34139847
35Taste transduction_Homo sapiens_hsa047421.29120208
36* Osteoclast differentiation_Homo sapiens_hsa043801.28802660
37Pentose phosphate pathway_Homo sapiens_hsa000301.26440590
38* Gap junction_Homo sapiens_hsa045401.25829137
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21473568
40* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20969519
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20920846
42* Estrogen signaling pathway_Homo sapiens_hsa049151.18544714
43Amoebiasis_Homo sapiens_hsa051461.18354680
44* Glioma_Homo sapiens_hsa052141.17586010
45Vibrio cholerae infection_Homo sapiens_hsa051101.16213282
46* cAMP signaling pathway_Homo sapiens_hsa040241.14072022
47Type II diabetes mellitus_Homo sapiens_hsa049301.12357940
48* Oocyte meiosis_Homo sapiens_hsa041141.06925411
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06454480
50Leishmaniasis_Homo sapiens_hsa051401.04003735
51* Acute myeloid leukemia_Homo sapiens_hsa052211.03756930
52* Phospholipase D signaling pathway_Homo sapiens_hsa040721.00816075
53* Pancreatic cancer_Homo sapiens_hsa052120.99701168
54Adherens junction_Homo sapiens_hsa045200.97484594
55* Proteoglycans in cancer_Homo sapiens_hsa052050.97174335
56* ErbB signaling pathway_Homo sapiens_hsa040120.95338679
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.94902608
58* Focal adhesion_Homo sapiens_hsa045100.94845920
59* VEGF signaling pathway_Homo sapiens_hsa043700.93794018
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93781821
61* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92381684
62* Vascular smooth muscle contraction_Homo sapiens_hsa042700.91489409
63* T cell receptor signaling pathway_Homo sapiens_hsa046600.90799414
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90614869
65Other glycan degradation_Homo sapiens_hsa005110.89813428
66* Endometrial cancer_Homo sapiens_hsa052130.89620403
67* Melanogenesis_Homo sapiens_hsa049160.88203073
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88190267
69* Bladder cancer_Homo sapiens_hsa052190.88148381
70Toxoplasmosis_Homo sapiens_hsa051450.84626008
71Cardiac muscle contraction_Homo sapiens_hsa042600.84618647
72Notch signaling pathway_Homo sapiens_hsa043300.84119261
73Thyroid hormone synthesis_Homo sapiens_hsa049180.81186759
74mTOR signaling pathway_Homo sapiens_hsa041500.80139423
75* Hepatitis B_Homo sapiens_hsa051610.80069389
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79133328
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79080552
78* Thyroid cancer_Homo sapiens_hsa052160.79034678
79* Choline metabolism in cancer_Homo sapiens_hsa052310.78151901
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78126399
81* Influenza A_Homo sapiens_hsa051640.77582973
82* TNF signaling pathway_Homo sapiens_hsa046680.76887325
83Type I diabetes mellitus_Homo sapiens_hsa049400.76871874
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76071424
85Pancreatic secretion_Homo sapiens_hsa049720.74589843
86* Neurotrophin signaling pathway_Homo sapiens_hsa047220.74473589
87Fructose and mannose metabolism_Homo sapiens_hsa000510.74388580
88* MAPK signaling pathway_Homo sapiens_hsa040100.73253768
89Dilated cardiomyopathy_Homo sapiens_hsa054140.72309819
90Endocytosis_Homo sapiens_hsa041440.72139370
91* Apoptosis_Homo sapiens_hsa042100.71197047
92Small cell lung cancer_Homo sapiens_hsa052220.71018591
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.68519709
94* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67568064
95Vitamin B6 metabolism_Homo sapiens_hsa007500.67278027
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66209835
97Biosynthesis of amino acids_Homo sapiens_hsa012300.64121892
98Hepatitis C_Homo sapiens_hsa051600.63916006
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63790852
100* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63302868
101Axon guidance_Homo sapiens_hsa043600.63267392
102Pertussis_Homo sapiens_hsa051330.62975063
103* Sphingolipid signaling pathway_Homo sapiens_hsa040710.62085196
104* Dorso-ventral axis formation_Homo sapiens_hsa043200.61634693
105African trypanosomiasis_Homo sapiens_hsa051430.60776280
106Inositol phosphate metabolism_Homo sapiens_hsa005620.60320853
107Legionellosis_Homo sapiens_hsa051340.60251484
108AMPK signaling pathway_Homo sapiens_hsa041520.59652348
109HTLV-I infection_Homo sapiens_hsa051660.59502466
110Measles_Homo sapiens_hsa051620.59374825
111Phagosome_Homo sapiens_hsa041450.59150115
112Glucagon signaling pathway_Homo sapiens_hsa049220.59137012
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58961852
114* MicroRNAs in cancer_Homo sapiens_hsa052060.58626913
115Malaria_Homo sapiens_hsa051440.58553104
116* Rap1 signaling pathway_Homo sapiens_hsa040150.56588669
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55804105
118* Ras signaling pathway_Homo sapiens_hsa040140.55355274
119* Renal cell carcinoma_Homo sapiens_hsa052110.54046799
120* Prion diseases_Homo sapiens_hsa050200.53911310
121* Chemokine signaling pathway_Homo sapiens_hsa040620.53030845
122* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49726000
123* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47161942
124* Non-small cell lung cancer_Homo sapiens_hsa052230.45876191
125Rheumatoid arthritis_Homo sapiens_hsa053230.44705834
126Ovarian steroidogenesis_Homo sapiens_hsa049130.44576307
127Circadian rhythm_Homo sapiens_hsa047100.44565698
128Bile secretion_Homo sapiens_hsa049760.44192126
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42790050
130Salmonella infection_Homo sapiens_hsa051320.42226642
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42037381
132Shigellosis_Homo sapiens_hsa051310.39948485
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39455988
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39353885
135Platelet activation_Homo sapiens_hsa046110.38233676
136Tuberculosis_Homo sapiens_hsa051520.36982694
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36511786
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35175629
139* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34455575
140* HIF-1 signaling pathway_Homo sapiens_hsa040660.33728355
141* Central carbon metabolism in cancer_Homo sapiens_hsa052300.32686171
142Lysosome_Homo sapiens_hsa041420.32681589
143* Insulin signaling pathway_Homo sapiens_hsa049100.32677487
144* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30764462

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