MAP1LC3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.96043123
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.99918735
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.91393872
4plasma membrane repair (GO:0001778)4.78756957
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.77972982
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.70099640
7sarcomere organization (GO:0045214)4.48869293
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.44114915
9regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.42906281
10regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.35534227
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.29607571
12cell communication involved in cardiac conduction (GO:0086065)4.28521522
13regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.28378349
14neurotransmitter secretion (GO:0007269)4.27303294
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25302816
16tricarboxylic acid cycle (GO:0006099)4.15894817
17ventricular cardiac muscle cell action potential (GO:0086005)4.15457654
18cellular potassium ion homeostasis (GO:0030007)4.11760963
19cell communication by electrical coupling (GO:0010644)4.01527936
20locomotory exploration behavior (GO:0035641)3.93370446
21NADH metabolic process (GO:0006734)3.88571386
22cardiac myofibril assembly (GO:0055003)3.87664071
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.79508138
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.78295902
25vocalization behavior (GO:0071625)3.76710613
26regulation of membrane repolarization (GO:0060306)3.76102515
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.74188919
28cardiac muscle contraction (GO:0060048)3.66697309
29regulation of neuronal synaptic plasticity (GO:0048168)3.61449675
30carnitine shuttle (GO:0006853)3.61191401
31positive regulation of neurotransmitter secretion (GO:0001956)3.60425586
32dendritic spine morphogenesis (GO:0060997)3.58751428
33regulation of acyl-CoA biosynthetic process (GO:0050812)3.57510440
34regulation of cell communication by electrical coupling (GO:0010649)3.57509115
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55403705
36positive regulation of synapse maturation (GO:0090129)3.54097906
37myofibril assembly (GO:0030239)3.53454578
38sarcoplasmic reticulum calcium ion transport (GO:0070296)3.50201093
39synaptic vesicle maturation (GO:0016188)3.50122039
40neuronal ion channel clustering (GO:0045161)3.49006215
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.47927553
42positive regulation of neurotransmitter transport (GO:0051590)3.45112329
43exploration behavior (GO:0035640)3.44033765
44cell migration in hindbrain (GO:0021535)3.43618153
45synaptic transmission, glutamatergic (GO:0035249)3.43267222
46actin-myosin filament sliding (GO:0033275)3.41533212
47muscle filament sliding (GO:0030049)3.41533212
48negative regulation of amino acid transport (GO:0051956)3.40247820
49positive regulation of potassium ion transmembrane transport (GO:1901381)3.39225741
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35746518
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.35553770
52postsynaptic membrane organization (GO:0001941)3.33880672
53regulation of synapse structural plasticity (GO:0051823)3.33365073
54regulation of coenzyme metabolic process (GO:0051196)3.32436961
55regulation of cofactor metabolic process (GO:0051193)3.32436961
56neurotransmitter-gated ion channel clustering (GO:0072578)3.31948870
57neurotransmitter transport (GO:0006836)3.31911958
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28628897
59regulation of relaxation of muscle (GO:1901077)3.26705590
60cerebellar granule cell differentiation (GO:0021707)3.25599921
61protein localization to synapse (GO:0035418)3.21529669
62regulation of glutamate receptor signaling pathway (GO:1900449)3.19743292
63regulation of neurotransmitter secretion (GO:0046928)3.19148350
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18884988
65regulation of short-term neuronal synaptic plasticity (GO:0048172)3.16622065
66regulation of neurotransmitter levels (GO:0001505)3.15906749
67activation of protein kinase A activity (GO:0034199)3.15787994
68cardiac muscle cell action potential involved in contraction (GO:0086002)3.15758783
69regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15701209
70cardiac muscle cell development (GO:0055013)3.14916998
71regulation of calcium ion transmembrane transport (GO:1903169)3.13840023
72regulation of calcium ion transmembrane transporter activity (GO:1901019)3.13840023
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12227683
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12166285
75glutamate secretion (GO:0014047)3.10977979
76regulation of actin filament-based movement (GO:1903115)3.10348749
77fatty acid transmembrane transport (GO:1902001)3.08308479
78synaptic vesicle exocytosis (GO:0016079)3.07120148
79gamma-aminobutyric acid transport (GO:0015812)3.06838802
80cardiac muscle cell action potential (GO:0086001)3.06680961
81calcium-mediated signaling using intracellular calcium source (GO:0035584)3.06610098
82detection of temperature stimulus involved in sensory perception (GO:0050961)3.05824399
83detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.05824399
84dendritic spine organization (GO:0097061)3.04270641
85positive regulation of sodium ion transport (GO:0010765)3.02856986
86positive regulation of membrane potential (GO:0045838)3.01596556
87regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00559066
88regulation of skeletal muscle contraction (GO:0014819)2.99508369
89regulation of vesicle fusion (GO:0031338)2.98807181
90positive regulation of dendritic spine development (GO:0060999)2.98790889
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98580347
92neuron cell-cell adhesion (GO:0007158)2.98190132
93regulation of synapse maturation (GO:0090128)2.97134731
94neuron-neuron synaptic transmission (GO:0007270)2.96699963
95negative regulation of potassium ion transport (GO:0043267)2.95907097
96regulation of synaptic plasticity (GO:0048167)2.95608337
97mitochondrion transport along microtubule (GO:0047497)2.95450937
98establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95450937
99striated muscle contraction (GO:0006941)2.95173386
100regulation of sodium ion transmembrane transporter activity (GO:2000649)2.93551266
101regulation of voltage-gated calcium channel activity (GO:1901385)2.91875967
102regulation of heart rate (GO:0002027)2.90065983
103regulation of ARF protein signal transduction (GO:0032012)2.89997878
104neurofilament cytoskeleton organization (GO:0060052)2.89909499
105cardiac cell development (GO:0055006)2.89554670
106negative regulation of microtubule polymerization (GO:0031115)2.89554050
107regulation of sodium ion transmembrane transport (GO:1902305)2.88728060
108regulation of striated muscle contraction (GO:0006942)2.88656782
109CDP-diacylglycerol metabolic process (GO:0046341)2.87501508
110establishment of mitochondrion localization (GO:0051654)2.87109266
111layer formation in cerebral cortex (GO:0021819)2.86639363
112sodium ion export (GO:0071436)2.86615287
113actomyosin structure organization (GO:0031032)2.86079949
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.85231535
115L-amino acid import (GO:0043092)2.85108038
116neuromuscular process controlling balance (GO:0050885)2.84840738
117positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.84840242
118neuromuscular process controlling posture (GO:0050884)2.84134940
119auditory behavior (GO:0031223)2.83910588
120regulation of neurotransmitter transport (GO:0051588)2.83438061
121detection of temperature stimulus (GO:0016048)2.82680211
122membrane depolarization during action potential (GO:0086010)2.82656446
123regulation of heart rate by cardiac conduction (GO:0086091)2.81148187
124regulation of postsynaptic membrane potential (GO:0060078)2.80109255
125synaptic vesicle endocytosis (GO:0048488)2.78515604
126neuronal action potential propagation (GO:0019227)2.77452130
127positive regulation of potassium ion transport (GO:0043268)2.77388080
128negative regulation of dendrite morphogenesis (GO:0050774)2.76334418
129regulation of potassium ion transmembrane transporter activity (GO:1901016)2.75189717
130carnitine transmembrane transport (GO:1902603)2.75044056
131heart trabecula formation (GO:0060347)2.75016065
132regulation of synaptic vesicle exocytosis (GO:2000300)2.71254436
133actin-mediated cell contraction (GO:0070252)2.70923417
134cardiac conduction (GO:0061337)2.70897169
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69828195
136glutamate receptor signaling pathway (GO:0007215)2.69690054
137respiratory electron transport chain (GO:0022904)2.69654584
138regulation of potassium ion transmembrane transport (GO:1901379)2.69311355
139regulation of cardiac muscle contraction (GO:0055117)2.66920502
140negative regulation of ion transmembrane transporter activity (GO:0032413)2.66440530
141negative regulation of calcium ion transmembrane transport (GO:1903170)2.66302487
142negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.66302487
143amino acid import (GO:0043090)2.66231095
144potassium ion homeostasis (GO:0055075)2.65951187
145detection of calcium ion (GO:0005513)2.65806978
146regulation of sulfur metabolic process (GO:0042762)2.65071601
147regulation of cation channel activity (GO:2001257)2.64808101
148neuromuscular synaptic transmission (GO:0007274)2.64725129
149G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64004759
150electron transport chain (GO:0022900)2.63954529
151growth hormone secretion (GO:0030252)2.63606723
152membrane repolarization (GO:0086009)2.63102382
153negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62572148
154acidic amino acid transport (GO:0015800)2.61537132
155membrane depolarization (GO:0051899)2.60549444
156regulation of synaptic vesicle transport (GO:1902803)2.59299985
157potassium ion import (GO:0010107)2.59286509
158regulation of glutamate secretion (GO:0014048)2.59221968
159response to auditory stimulus (GO:0010996)2.58223940
160axonal fasciculation (GO:0007413)2.51129087
161regulation of synaptic transmission (GO:0050804)2.48008591
162transmission of nerve impulse (GO:0019226)2.46955605
163calcium ion-dependent exocytosis (GO:0017156)2.46042586
164response to dietary excess (GO:0002021)2.45913912
165prepulse inhibition (GO:0060134)2.45014732
166regulation of synaptic transmission, glutamatergic (GO:0051966)2.44301975
167gamma-aminobutyric acid signaling pathway (GO:0007214)2.44224012
168axon ensheathment in central nervous system (GO:0032291)2.43969501
169central nervous system myelination (GO:0022010)2.43969501
170signal release (GO:0023061)2.42757788
171synaptic vesicle transport (GO:0048489)2.40559049
172establishment of synaptic vesicle localization (GO:0097480)2.40559049
173synaptic transmission (GO:0007268)2.39371490
174regulation of dendritic spine development (GO:0060998)2.39056838
175long-term memory (GO:0007616)2.37027903
176regulation of dendritic spine morphogenesis (GO:0061001)2.35896991
177membrane hyperpolarization (GO:0060081)2.35490901
178pyrimidine nucleobase catabolic process (GO:0006208)2.33603389
179regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33588865
180cerebellar Purkinje cell differentiation (GO:0021702)2.32830720
181neuron recognition (GO:0008038)2.32035784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62932005
2EZH2_22144423_ChIP-Seq_EOC_Human3.54497189
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.23425889
4ZNF263_19887448_ChIP-Seq_K562_Human3.20359008
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21825873
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19381354
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19218846
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16994605
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12848624
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12848624
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06860151
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04712600
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03605339
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.01237009
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.92600112
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92454801
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89176039
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88040198
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83495540
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.80899328
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80705604
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.80334527
23REST_21632747_ChIP-Seq_MESCs_Mouse1.78055785
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.76554701
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.73452560
26CTCF_27219007_Chip-Seq_Bcells_Human1.69208908
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.68878704
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65700899
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62184327
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61254788
31DROSHA_22980978_ChIP-Seq_HELA_Human1.60385574
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59158859
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56020642
34ZNF274_21170338_ChIP-Seq_K562_Hela1.53649089
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51902009
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.46290120
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.42487783
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.41953533
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41774266
40KDM2B_26808549_Chip-Seq_K562_Human1.39014240
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37084474
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35480463
43TET1_21490601_ChIP-Seq_MESCs_Mouse1.35227249
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32091100
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31147216
46LXR_22292898_ChIP-Seq_THP-1_Human1.31093770
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30201587
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.29852822
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.29852822
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29571895
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25948665
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24427851
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21084000
54SMC4_20622854_ChIP-Seq_HELA_Human1.18526133
55* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17019884
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15750219
57GBX2_23144817_ChIP-Seq_PC3_Human1.14268311
58P68_20966046_ChIP-Seq_HELA_Human1.14255655
59* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12880346
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.11379970
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11315633
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08082118
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.07992492
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07590516
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.05325992
66CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05024640
67* TP63_22573176_ChIP-Seq_HFKS_Human1.04157216
68RACK7_27058665_Chip-Seq_MCF-7_Human1.03629071
69FOXH1_21741376_ChIP-Seq_ESCs_Human1.03213279
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03047171
71* KLF4_19829295_ChIP-Seq_ESCs_Human1.02817428
72CLOCK_20551151_ChIP-Seq_293T_Human1.02598655
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01514116
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01400143
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01199752
76KDM2B_26808549_Chip-Seq_DND41_Human1.00227539
77OCT4_19829295_ChIP-Seq_ESCs_Human0.98779041
78* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98044143
79SA1_27219007_Chip-Seq_Bcells_Human0.98035310
80TP53_20018659_ChIP-ChIP_R1E_Mouse0.97978461
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96480975
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95235573
83* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94655143
84ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94460625
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94086717
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92779579
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92645108
88TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92335962
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91795097
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.91306948
91MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90264825
92CREB1_26743006_Chip-Seq_LNCaP_Human0.89239320
93BCOR_27268052_Chip-Seq_Bcells_Human0.87504430
94SA1_27219007_Chip-Seq_ERYTHROID_Human0.87476978
95OCT4_20526341_ChIP-Seq_ESCs_Human0.87431846
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87170423
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87125989
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85949634
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84980032
100EGR1_19032775_ChIP-ChIP_M12_Human0.84213478
101E2F1_20622854_ChIP-Seq_HELA_Human0.83138458
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.82803636
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81220373
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81176651
105ATF3_27146783_Chip-Seq_COLON_Human0.80476090
106BCL6_27268052_Chip-Seq_Bcells_Human0.80432291
107SOX2_21211035_ChIP-Seq_LN229_Gbm0.80421009
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79678358
109AHR_22903824_ChIP-Seq_MCF-7_Human0.78541022
110RING1B_27294783_Chip-Seq_NPCs_Mouse0.78148729
111BP1_19119308_ChIP-ChIP_Hs578T_Human0.77458109
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.76925389
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.76647712
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.76136753
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75979245
116CTCF_20526341_ChIP-Seq_ESCs_Human0.75887796
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.75786286
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75575862
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.74382980
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72992820
121DPY_21335234_ChIP-Seq_ESCs_Mouse0.71808895
122* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.71204965
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71188067
124TP53_23651856_ChIP-Seq_MEFs_Mouse0.70499373
125JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.69504842
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69287304
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69224047
128SMAD4_21741376_ChIP-Seq_ESCs_Human0.68923647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.96322842
2MP0000751_myopathy4.23137219
3MP0003646_muscle_fatigue4.02294094
4MP0004084_abnormal_cardiac_muscle3.54365170
5MP0004215_abnormal_myocardial_fiber3.00982296
6MP0004859_abnormal_synaptic_plasticity2.99670784
7MP0004270_analgesia2.96971209
8MP0004036_abnormal_muscle_relaxation2.90499176
9MP0000749_muscle_degeneration2.82740450
10MP0002735_abnormal_chemical_nociception2.75500368
11MP0005330_cardiomyopathy2.46028214
12MP0004858_abnormal_nervous_system2.40450329
13MP0001501_abnormal_sleep_pattern2.37462258
14MP0004145_abnormal_muscle_electrophysio2.30190966
15MP0001968_abnormal_touch/_nociception2.17153913
16MP0004087_abnormal_muscle_fiber2.12690124
17MP0004130_abnormal_muscle_cell2.11714834
18MP0000750_abnormal_muscle_regeneration2.11637510
19MP0000747_muscle_weakness2.11176297
20MP0002972_abnormal_cardiac_muscle2.06049541
21MP0003303_peritoneal_inflammation2.05779848
22MP0002734_abnormal_mechanical_nocicepti2.03638268
23MP0003137_abnormal_impulse_conducting2.03195295
24MP0003329_amyloid_beta_deposits1.98989605
25MP0005620_abnormal_muscle_contractility1.96364976
26MP0002269_muscular_atrophy1.94701246
27MP0002733_abnormal_thermal_nociception1.86254286
28MP0003635_abnormal_synaptic_transmissio1.84525220
29MP0006276_abnormal_autonomic_nervous1.83196692
30MP0002106_abnormal_muscle_physiology1.82408642
31MP0008775_abnormal_heart_ventricle1.82203249
32MP0005167_abnormal_blood-brain_barrier1.81593505
33MP0003075_altered_response_to1.76187754
34MP0002736_abnormal_nociception_after1.72721240
35MP0004484_altered_response_of1.72449526
36MP0001970_abnormal_pain_threshold1.72120842
37MP0002909_abnormal_adrenal_gland1.71377490
38MP0000759_abnormal_skeletal_muscle1.69833217
39MP0004085_abnormal_heartbeat1.68379429
40MP0003690_abnormal_glial_cell1.67529516
41MP0003880_abnormal_central_pattern1.61615543
42MP0005385_cardiovascular_system_phenoty1.58369573
43MP0001544_abnormal_cardiovascular_syste1.58369573
44MP0004233_abnormal_muscle_weight1.55818430
45MP0006138_congestive_heart_failure1.54859737
46MP0005369_muscle_phenotype1.54517086
47MP0000920_abnormal_myelination1.52077957
48MP0003787_abnormal_imprinting1.45360894
49MP0002557_abnormal_social/conspecific_i1.44276178
50MP0003221_abnormal_cardiomyocyte_apopto1.42213290
51MP0000013_abnormal_adipose_tissue1.41757355
52MP0009046_muscle_twitch1.36579426
53MP0002272_abnormal_nervous_system1.35997064
54MP0006036_abnormal_mitochondrial_physio1.34236186
55MP0002063_abnormal_learning/memory/cond1.32832630
56MP0001440_abnormal_grooming_behavior1.31407342
57MP0010630_abnormal_cardiac_muscle1.30804233
58MP0002064_seizures1.30676812
59MP0002184_abnormal_innervation1.27118190
60MP0009745_abnormal_behavioral_response1.26404871
61MP0001502_abnormal_circadian_rhythm1.23600341
62MP0008874_decreased_physiological_sensi1.23288382
63MP0003631_nervous_system_phenotype1.20740829
64MP0005646_abnormal_pituitary_gland1.14568443
65MP0003724_increased_susceptibility_to1.12176259
66MP0005666_abnormal_adipose_tissue1.08810691
67MP0003122_maternal_imprinting1.07407579
68MP0002234_abnormal_pharynx_morphology1.06876755
69MP0002653_abnormal_ependyma_morphology1.05130264
70MP0002067_abnormal_sensory_capabilities1.05065954
71MP0005386_behavior/neurological_phenoty1.03843046
72MP0004924_abnormal_behavior1.03843046
73MP0002332_abnormal_exercise_endurance1.03615580
74MP0002822_catalepsy1.03209001
75MP0005670_abnormal_white_adipose1.02952826
76MP0005166_decreased_susceptibility_to1.02004276
77MP0004742_abnormal_vestibular_system1.01092112
78MP0003123_paternal_imprinting0.99715174
79MP0005423_abnormal_somatic_nervous0.99155480
80MP0008569_lethality_at_weaning0.99083077
81MP0004811_abnormal_neuron_physiology0.98578087
82MP0000955_abnormal_spinal_cord0.98317933
83MP0002572_abnormal_emotion/affect_behav0.97505699
84MP0009780_abnormal_chondrocyte_physiolo0.95423805
85MP0004885_abnormal_endolymph0.95329388
86MP0005058_abnormal_lysosome_morphology0.95014646
87MP0003879_abnormal_hair_cell0.94046259
88MP0006035_abnormal_mitochondrial_morpho0.93993079
89MP0009840_abnormal_foam_cell0.89953010
90MP0006082_CNS_inflammation0.88144073
91MP0004510_myositis0.87840912
92MP0002229_neurodegeneration0.86614598
93MP0003183_abnormal_peptide_metabolism0.86390054
94MP0003172_abnormal_lysosome_physiology0.85433157
95MP0005535_abnormal_body_temperature0.85125622
96MP0005623_abnormal_meninges_morphology0.84441182
97MP0009278_abnormal_bone_marrow0.84088664
98MP0005375_adipose_tissue_phenotype0.83798990
99MP0000343_altered_response_to0.83035284
100MP0002066_abnormal_motor_capabilities/c0.82726671
101MP0001486_abnormal_startle_reflex0.81770490
102MP0004185_abnormal_adipocyte_glucose0.81594763
103MP0000230_abnormal_systemic_arterial0.80625664
104MP0002127_abnormal_cardiovascular_syste0.79792706
105MP0001963_abnormal_hearing_physiology0.79115943
106MP0009764_decreased_sensitivity_to0.78263130
107MP0002108_abnormal_muscle_morphology0.78090781
108MP0008260_abnormal_autophagy0.76798123
109MP0001299_abnormal_eye_distance/0.76797714
110MP0005275_abnormal_skin_tensile0.76613183
111MP0002882_abnormal_neuron_morphology0.76207306
112MP0000604_amyloidosis0.75357666
113MP0010386_abnormal_urinary_bladder0.72767612
114MP0008961_abnormal_basal_metabolism0.72341903
115MP0003436_decreased_susceptibility_to0.71689013
116MP0002069_abnormal_eating/drinking_beha0.71348639
117MP0003279_aneurysm0.70450679
118MP0005083_abnormal_biliary_tract0.69732878
119MP0003828_pulmonary_edema0.69672485
120MP0000778_abnormal_nervous_system0.69072224
121MP0001905_abnormal_dopamine_level0.68991272
122MP0002152_abnormal_brain_morphology0.68492292
123MP0000003_abnormal_adipose_tissue0.68075839
124MP0002295_abnormal_pulmonary_circulatio0.67614403
125MP0008004_abnormal_stomach_pH0.67280197
126MP0005448_abnormal_energy_balance0.66918166
127MP0001529_abnormal_vocalization0.66691919
128MP0004043_abnormal_pH_regulation0.66418876
129MP0003632_abnormal_nervous_system0.65871663
130MP0004142_abnormal_muscle_tone0.65007611
131MP0001542_abnormal_bone_strength0.64702063
132MP0001533_abnormal_skeleton_physiology0.64377559
133MP0003634_abnormal_glial_cell0.63351372
134MP0001984_abnormal_olfaction0.63093510
135MP0005165_increased_susceptibility_to0.61919627
136MP0002139_abnormal_hepatobiliary_system0.61377762
137MP0002638_abnormal_pupillary_reflex0.60749903
138MP0005410_abnormal_fertilization0.60703261
139MP0000579_abnormal_nail_morphology0.60486760
140MP0001348_abnormal_lacrimal_gland0.60334742
141MP0002148_abnormal_hypersensitivity_rea0.60057631
142MP0001756_abnormal_urination0.59833504
143MP0003633_abnormal_nervous_system0.59657932
144MP0005595_abnormal_vascular_smooth0.57735346
145MP0002876_abnormal_thyroid_physiology0.56108695

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.43523860
2Muscle fiber splitting (HP:0003555)4.72476441
3Neurofibrillary tangles (HP:0002185)4.64313331
4Bundle branch block (HP:0011710)4.47275812
5Exercise-induced myalgia (HP:0003738)4.46915101
6Hyporeflexia of lower limbs (HP:0002600)4.43378510
7Myokymia (HP:0002411)4.30725201
8Ventricular fibrillation (HP:0001663)4.28818785
9Mutism (HP:0002300)4.23230317
10Calf muscle hypertrophy (HP:0008981)4.04318776
11Myotonia (HP:0002486)3.92766600
12Diplopia (HP:0000651)3.86929703
13Abnormality of binocular vision (HP:0011514)3.86929703
14Abnormal eating behavior (HP:0100738)3.85546115
15Ventricular tachycardia (HP:0004756)3.83622767
16Atonic seizures (HP:0010819)3.80739291
17Muscle hypertrophy of the lower extremities (HP:0008968)3.78677080
18Polyphagia (HP:0002591)3.72701406
19Febrile seizures (HP:0002373)3.69112120
20Exercise-induced muscle cramps (HP:0003710)3.68184301
21Epileptic encephalopathy (HP:0200134)3.61369863
22Pheochromocytoma (HP:0002666)3.58119182
23Cerebral inclusion bodies (HP:0100314)3.56275952
24Syncope (HP:0001279)3.56239006
25Abnormality of the calf musculature (HP:0001430)3.52859754
26Limb dystonia (HP:0002451)3.50521203
27Torticollis (HP:0000473)3.49853066
28Myoglobinuria (HP:0002913)3.46657410
29Atrial fibrillation (HP:0005110)3.45703870
30Atrioventricular block (HP:0001678)3.35859746
31Primary atrial arrhythmia (HP:0001692)3.35619270
32Palpitations (HP:0001962)3.35220989
33Heart block (HP:0012722)3.32874594
34Spastic gait (HP:0002064)3.30617229
35Focal dystonia (HP:0004373)3.26868093
36EMG: myopathic abnormalities (HP:0003458)3.24231477
37Right ventricular cardiomyopathy (HP:0011663)3.22010036
38Difficulty climbing stairs (HP:0003551)3.21925780
39Abnormal atrioventricular conduction (HP:0005150)3.21565625
40Supraventricular tachycardia (HP:0004755)3.21446336
41Difficulty running (HP:0009046)3.14814708
42Supraventricular arrhythmia (HP:0005115)3.14781131
43Neuroendocrine neoplasm (HP:0100634)3.14564367
44Ventricular arrhythmia (HP:0004308)3.09934027
45Prolonged QT interval (HP:0001657)3.05645267
46Papilledema (HP:0001085)3.03599523
47Craniofacial dystonia (HP:0012179)3.03248464
48Generalized tonic-clonic seizures (HP:0002069)3.01401066
49Increased connective tissue (HP:0009025)3.00328370
50Neuronal loss in central nervous system (HP:0002529)2.90369614
51Areflexia of lower limbs (HP:0002522)2.87314198
52Progressive cerebellar ataxia (HP:0002073)2.86189959
53Lipoatrophy (HP:0100578)2.78667446
54Postural instability (HP:0002172)2.71404534
55Intention tremor (HP:0002080)2.70362678
56Abnormal EKG (HP:0003115)2.70203953
57Absence seizures (HP:0002121)2.68398143
58Urinary bladder sphincter dysfunction (HP:0002839)2.63072893
59Obstructive sleep apnea (HP:0002870)2.62437772
60Foot dorsiflexor weakness (HP:0009027)2.60705699
61Dialeptic seizures (HP:0011146)2.59282774
62Asymmetric septal hypertrophy (HP:0001670)2.59046456
63Apathy (HP:0000741)2.56072580
64Muscle stiffness (HP:0003552)2.52523776
65Axonal loss (HP:0003447)2.52212972
66Dysmetria (HP:0001310)2.49399252
67Visual hallucinations (HP:0002367)2.48433215
68Increased variability in muscle fiber diameter (HP:0003557)2.47020213
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.45536158
70Abnormality of glycolipid metabolism (HP:0010969)2.45536158
71Abnormality of liposaccharide metabolism (HP:0010968)2.45536158
72Rhabdomyolysis (HP:0003201)2.44950803
73Lower limb muscle weakness (HP:0007340)2.44530623
74Abnormality of the foot musculature (HP:0001436)2.44066441
75Annular pancreas (HP:0001734)2.43333024
76Truncal ataxia (HP:0002078)2.43233176
77Distal lower limb muscle weakness (HP:0009053)2.42479190
78Peripheral hypomyelination (HP:0007182)2.41681529
79Diminished motivation (HP:0000745)2.39650469
80Ulnar claw (HP:0001178)2.37795294
81Ankle clonus (HP:0011448)2.37584412
82Impaired vibration sensation in the lower limbs (HP:0002166)2.36972739
83Sleep apnea (HP:0010535)2.36900631
84Hemiplegia (HP:0002301)2.36454889
85Gout (HP:0001997)2.34749284
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34059148
87Dilated cardiomyopathy (HP:0001644)2.32880050
88Systemic lupus erythematosus (HP:0002725)2.30778332
89Impaired pain sensation (HP:0007328)2.29457179
90Abnormality of pain sensation (HP:0010832)2.29457179
91Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29352141
92Tetraplegia (HP:0002445)2.29270577
93Muscle fiber inclusion bodies (HP:0100299)2.28579351
94Epileptiform EEG discharges (HP:0011182)2.28564469
95Action tremor (HP:0002345)2.27658856
96Amblyopia (HP:0000646)2.27526855
97Akinesia (HP:0002304)2.27343486
98Supranuclear gaze palsy (HP:0000605)2.25905788
99EMG: neuropathic changes (HP:0003445)2.25414029
100Spastic tetraparesis (HP:0001285)2.24399215
101Distal arthrogryposis (HP:0005684)2.21045107
102Neoplasm of the peripheral nervous system (HP:0100007)2.20888184
103Rapidly progressive (HP:0003678)2.20110113
104Distal upper limb amyotrophy (HP:0007149)2.19989157
105Upper limb amyotrophy (HP:0009129)2.19989157
106Type 1 muscle fiber predominance (HP:0003803)2.19352972
107Hand muscle atrophy (HP:0009130)2.18264988
108Abnormality of skeletal muscle fiber size (HP:0012084)2.16796804
109Rigidity (HP:0002063)2.16318212
110Cerebral hypomyelination (HP:0006808)2.16146959
111Focal motor seizures (HP:0011153)2.15577813
112Clonus (HP:0002169)2.15380838
113Nuclear cataract (HP:0100018)2.15075176
114Bradykinesia (HP:0002067)2.14442798
115Focal seizures (HP:0007359)2.11464479
116Dementia (HP:0000726)2.11409974
117Abnormal mitochondria in muscle tissue (HP:0008316)2.10868192
118EEG with generalized epileptiform discharges (HP:0011198)2.08129510
119Progressive muscle weakness (HP:0003323)2.07645614
120Acute necrotizing encephalopathy (HP:0006965)2.07004990
121Subaortic stenosis (HP:0001682)2.06915295
122Abnormality of the left ventricular outflow tract (HP:0011103)2.06915295
123Athetosis (HP:0002305)2.04314308
124Lower limb amyotrophy (HP:0007210)2.01057806
125Testicular atrophy (HP:0000029)2.00867127
126Limb-girdle muscle atrophy (HP:0003797)2.00795204
127Left ventricular hypertrophy (HP:0001712)1.98503711
128Nemaline bodies (HP:0003798)1.97345700
129Ketoacidosis (HP:0001993)1.96942155
130Dysostosis multiplex (HP:0000943)1.96376822
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96107473
132Abnormality of alanine metabolism (HP:0010916)1.96107473
133Hyperalaninemia (HP:0003348)1.96107473
134Hemiparesis (HP:0001269)1.95849085
135Hypsarrhythmia (HP:0002521)1.95833589
136Amyloidosis (HP:0011034)1.94889277
137Hepatic necrosis (HP:0002605)1.94772386
138Status epilepticus (HP:0002133)1.92882293
139Neck muscle weakness (HP:0000467)1.91601480
140Hypercortisolism (HP:0001578)1.90913675
141Fetal akinesia sequence (HP:0001989)1.90624589
142Gowers sign (HP:0003391)1.90206199
143Memory impairment (HP:0002354)1.89557847
144Achilles tendon contracture (HP:0001771)1.88499709
145Abnormality of the vocal cords (HP:0008777)1.87549686
146Bradycardia (HP:0001662)1.85354041
147Hyperglycinuria (HP:0003108)1.84189025
148Hepatocellular necrosis (HP:0001404)1.83409340
149Abnormality of the lower motor neuron (HP:0002366)1.81957030
150Delusions (HP:0000746)1.81542457
151Spastic tetraplegia (HP:0002510)1.80155389
152Acute encephalopathy (HP:0006846)1.79301293
153Termporal pattern (HP:0011008)1.79200211
154Insidious onset (HP:0003587)1.79200211
155Urinary urgency (HP:0000012)1.78704380
156Agitation (HP:0000713)1.77536036
157Failure to thrive in infancy (HP:0001531)1.73973934
158Anxiety (HP:0000739)1.73918240
159Depression (HP:0000716)1.71923324
160Abnormality of the Achilles tendon (HP:0005109)1.71553383
161Oligomenorrhea (HP:0000876)1.71324032
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71315629
163Rimmed vacuoles (HP:0003805)1.71001815
164Absent speech (HP:0001344)1.70255392
165Progressive macrocephaly (HP:0004481)1.70191526
166Poor eye contact (HP:0000817)1.70088628
167Stereotypic behavior (HP:0000733)1.69659520
168Cerebral hemorrhage (HP:0001342)1.69539979
169Abnormality of polysaccharide metabolism (HP:0011012)1.69300060
170Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69300060
171Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69300060
172Abnormality of the corticospinal tract (HP:0002492)1.68999595
173Neoplasm of the adrenal gland (HP:0100631)1.68581608
174Psychosis (HP:0000709)1.65290165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG23.52966237
2PHKG13.52966237
3LMTK23.40686025
4PDK33.02298823
5PDK43.02298823
6MAP3K92.74294818
7MARK12.63375527
8TTN2.53260520
9LATS22.44380472
10NEK12.35351156
11PINK12.28979488
12NTRK12.19216270
13TRIB32.18408232
14KSR22.17801811
15MINK12.00773524
16PAK61.88270371
17PDK21.87308599
18NTRK31.78250716
19ARAF1.73158746
20MAPKAPK31.71979639
21MYLK1.71692186
22LIMK11.71335867
23BCKDK1.70535169
24GRK51.69551425
25RIPK41.65029044
26OBSCN1.62434142
27SIK21.53507817
28PAK31.47446795
29DDR21.46323003
30PRKD31.45698203
31DAPK21.33730617
32TYRO31.33016631
33MARK21.32832924
34STK381.28436805
35PLK21.25927270
36MAP2K41.24911577
37MAP3K41.22699658
38CASK1.18683123
39PRPF4B1.16396592
40DMPK1.10723576
41CDK191.10239955
42TAOK11.09841953
43PIM21.07993775
44TAOK21.07523505
45WNK41.06708042
46FER1.05664193
47DYRK1B1.04241477
48PKN21.04017327
49CAMKK11.01871455
50MUSK0.99490459
51RET0.98373036
52MAP3K20.97372268
53MAP3K120.94533808
54DAPK10.93663083
55MAP2K10.93052019
56TESK10.92336286
57DAPK30.88868870
58CAMK2D0.86669864
59EPHA40.85155466
60NME10.84006440
61CAMKK20.82743875
62PRKCH0.81375446
63ABL20.80021202
64CDK50.79019653
65PDPK10.78041263
66MOS0.76832411
67MAPK120.76601192
68CAMK2G0.75861955
69STK390.75813450
70DYRK1A0.75415867
71PRKD10.73465971
72KSR10.71489725
73TNK20.70490470
74EPHA30.68433315
75ILK0.68293104
76CAMK2A0.67809844
77PTK2B0.67221418
78PRKCG0.66967849
79MAP3K10.66879681
80STK240.66631305
81CDK140.65553249
82TBK10.63657707
83AKT30.63454036
84ROCK10.61554250
85CAMK40.61309077
86ERN10.60860799
87RIPK10.60833224
88MAPK40.60079160
89PRKAA10.60003998
90EPHB20.59480121
91MAP2K70.59045283
92MAP3K110.58815871
93GRK70.57952304
94MAPK150.56399552
95STK110.56113979
96PDK10.55633568
97UHMK10.54993224
98MAPK130.54859743
99PIK3CA0.54716552
100STK38L0.54242975
101NTRK20.53850760
102CAMK10.53761721
103CDC42BPA0.52294193
104PRKCE0.51485261
105CDK180.50959349
106WNK10.50638548
107PRKG20.50325983
108CDK150.50145924
109FYN0.49090048
110MAP2K60.48676652
111ROCK20.48120298
112PRKD20.47537528
113DYRK20.46842115
114SGK10.46059484
115RPS6KA20.45255984
116SGK2230.44317622
117SGK4940.44317622
118SGK30.43967112
119TESK20.43661014
120SGK20.43627046
121MAP3K50.43596362
122ICK0.42864816
123MAPK70.42402305
124IRAK30.41656455
125CDK11A0.41462647
126JAK20.40920907
127BRAF0.40818276
128PDGFRA0.38329849
129PRKCA0.38221316
130EPHB10.37599269
131PRKCZ0.37473377
132CAMK2B0.35686413
133TIE10.35574873
134CSNK1G20.35224853
135PRKACG0.34798133
136PKN10.32998769
137PNCK0.32653874

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.78458433
2Cardiac muscle contraction_Homo sapiens_hsa042602.99805747
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83522179
4Synaptic vesicle cycle_Homo sapiens_hsa047212.37574354
5Oxidative phosphorylation_Homo sapiens_hsa001902.35860323
6Parkinsons disease_Homo sapiens_hsa050122.33944564
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22433878
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22247017
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02483932
10Dilated cardiomyopathy_Homo sapiens_hsa054142.02009365
11Propanoate metabolism_Homo sapiens_hsa006401.90572537
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.84006846
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79822598
14Alzheimers disease_Homo sapiens_hsa050101.74077509
15Fatty acid degradation_Homo sapiens_hsa000711.58489556
16Carbon metabolism_Homo sapiens_hsa012001.58306727
17Fatty acid metabolism_Homo sapiens_hsa012121.51620030
18Huntingtons disease_Homo sapiens_hsa050161.45203799
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42345718
20Butanoate metabolism_Homo sapiens_hsa006501.41295198
21Pyruvate metabolism_Homo sapiens_hsa006201.39643852
22Olfactory transduction_Homo sapiens_hsa047401.35281067
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34065912
24Vitamin B6 metabolism_Homo sapiens_hsa007501.33417105
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33136369
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31901321
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31678945
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27990758
29Insulin secretion_Homo sapiens_hsa049111.27247209
30Circadian entrainment_Homo sapiens_hsa047131.24765074
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20554313
32Collecting duct acid secretion_Homo sapiens_hsa049661.16756107
33Gastric acid secretion_Homo sapiens_hsa049711.13052764
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10547100
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08525811
36Regulation of autophagy_Homo sapiens_hsa041401.08000708
37GABAergic synapse_Homo sapiens_hsa047271.07371139
38Insulin signaling pathway_Homo sapiens_hsa049101.07234583
39Oxytocin signaling pathway_Homo sapiens_hsa049211.05612236
40Long-term potentiation_Homo sapiens_hsa047201.04148779
41Dopaminergic synapse_Homo sapiens_hsa047281.02810329
42Salivary secretion_Homo sapiens_hsa049700.99623166
43Cholinergic synapse_Homo sapiens_hsa047250.99286441
44Rheumatoid arthritis_Homo sapiens_hsa053230.97850097
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94658061
46Calcium signaling pathway_Homo sapiens_hsa040200.93853178
47Glucagon signaling pathway_Homo sapiens_hsa049220.93821433
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93463803
49Amphetamine addiction_Homo sapiens_hsa050310.93196686
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89586709
51Salmonella infection_Homo sapiens_hsa051320.89460743
52Gap junction_Homo sapiens_hsa045400.87732287
53GnRH signaling pathway_Homo sapiens_hsa049120.86641614
54Nicotine addiction_Homo sapiens_hsa050330.84713544
55Taste transduction_Homo sapiens_hsa047420.84707977
56Renin secretion_Homo sapiens_hsa049240.84218833
57Glutamatergic synapse_Homo sapiens_hsa047240.83756614
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.83154320
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82763306
60Pertussis_Homo sapiens_hsa051330.82531017
61Fatty acid elongation_Homo sapiens_hsa000620.82116133
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80997376
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79631238
64Morphine addiction_Homo sapiens_hsa050320.77813603
65Biosynthesis of amino acids_Homo sapiens_hsa012300.77287719
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76793798
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75107224
68PPAR signaling pathway_Homo sapiens_hsa033200.74915032
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.74882843
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.71829887
71Type II diabetes mellitus_Homo sapiens_hsa049300.70258273
72Estrogen signaling pathway_Homo sapiens_hsa049150.69074692
73Vibrio cholerae infection_Homo sapiens_hsa051100.68862291
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68483327
75Fatty acid biosynthesis_Homo sapiens_hsa000610.68104931
76Lysosome_Homo sapiens_hsa041420.67880103
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67583187
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.66674900
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.66289446
80Mineral absorption_Homo sapiens_hsa049780.65570356
81MAPK signaling pathway_Homo sapiens_hsa040100.65533111
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.65464790
83African trypanosomiasis_Homo sapiens_hsa051430.65213010
84Oocyte meiosis_Homo sapiens_hsa041140.65029882
85Fructose and mannose metabolism_Homo sapiens_hsa000510.64529539
86VEGF signaling pathway_Homo sapiens_hsa043700.64506404
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63908150
88AMPK signaling pathway_Homo sapiens_hsa041520.63586728
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63440754
90Osteoclast differentiation_Homo sapiens_hsa043800.63363801
91cAMP signaling pathway_Homo sapiens_hsa040240.63024270
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62641362
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62294962
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60425772
95Dorso-ventral axis formation_Homo sapiens_hsa043200.59672545
96Arginine biosynthesis_Homo sapiens_hsa002200.58348050
97Phagosome_Homo sapiens_hsa041450.58136914
98Chemokine signaling pathway_Homo sapiens_hsa040620.57237456
99Ras signaling pathway_Homo sapiens_hsa040140.56650412
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.56373597
101Rap1 signaling pathway_Homo sapiens_hsa040150.55229984
102Tight junction_Homo sapiens_hsa045300.54782773
103TNF signaling pathway_Homo sapiens_hsa046680.54736479
104Insulin resistance_Homo sapiens_hsa049310.54287173
105Cocaine addiction_Homo sapiens_hsa050300.53904588
106Glioma_Homo sapiens_hsa052140.53094194
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53081612
108Axon guidance_Homo sapiens_hsa043600.52242525
109ErbB signaling pathway_Homo sapiens_hsa040120.52044696
110Tuberculosis_Homo sapiens_hsa051520.51568224
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51494680
112Renal cell carcinoma_Homo sapiens_hsa052110.51232785
113Phenylalanine metabolism_Homo sapiens_hsa003600.51033487
114Glycerolipid metabolism_Homo sapiens_hsa005610.50671388
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50658263
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50176259
117Prion diseases_Homo sapiens_hsa050200.50063528
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.49675541
119Serotonergic synapse_Homo sapiens_hsa047260.49548052
120Circadian rhythm_Homo sapiens_hsa047100.49443684
121Endocytosis_Homo sapiens_hsa041440.49014895
122Melanogenesis_Homo sapiens_hsa049160.48962599
123Amoebiasis_Homo sapiens_hsa051460.47727202
124Bile secretion_Homo sapiens_hsa049760.47347214
125mTOR signaling pathway_Homo sapiens_hsa041500.47302297
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46941392
127Pancreatic secretion_Homo sapiens_hsa049720.46752588
128Phototransduction_Homo sapiens_hsa047440.46225054
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45698194
130Arginine and proline metabolism_Homo sapiens_hsa003300.45228273
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44440378
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43891117
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43687882
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41277845
135HIF-1 signaling pathway_Homo sapiens_hsa040660.41099817
136Long-term depression_Homo sapiens_hsa047300.39917909
137Malaria_Homo sapiens_hsa051440.38766013
138Histidine metabolism_Homo sapiens_hsa003400.38674500
139Folate biosynthesis_Homo sapiens_hsa007900.35853695
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.33748165
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30673628

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