MAP1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.61487365
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.27252574
3locomotory exploration behavior (GO:0035641)6.13979609
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82289825
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.58084780
6vocalization behavior (GO:0071625)5.38326774
7glutamate secretion (GO:0014047)5.25865485
8synaptic vesicle exocytosis (GO:0016079)5.24654518
9regulation of synaptic vesicle exocytosis (GO:2000300)5.10568490
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07335041
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.04285378
12neuronal action potential propagation (GO:0019227)4.95117488
13regulation of glutamate receptor signaling pathway (GO:1900449)4.78439983
14cerebellar granule cell differentiation (GO:0021707)4.72763949
15regulation of neuronal synaptic plasticity (GO:0048168)4.69090038
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.58414535
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.57040058
18exploration behavior (GO:0035640)4.54922607
19neurotransmitter secretion (GO:0007269)4.53783104
20regulation of synaptic vesicle transport (GO:1902803)4.53121554
21protein localization to synapse (GO:0035418)4.49070661
22regulation of synapse structural plasticity (GO:0051823)4.48232905
23amino acid import (GO:0043090)4.39006101
24gamma-aminobutyric acid transport (GO:0015812)4.33087252
25dendritic spine morphogenesis (GO:0060997)4.30354934
26layer formation in cerebral cortex (GO:0021819)4.27987914
27cellular potassium ion homeostasis (GO:0030007)4.21404674
28central nervous system myelination (GO:0022010)4.15928359
29axon ensheathment in central nervous system (GO:0032291)4.15928359
30sodium ion export (GO:0071436)4.12562503
31neuron cell-cell adhesion (GO:0007158)4.09516680
32synaptic transmission, glutamatergic (GO:0035249)4.07954873
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07540601
34long-term memory (GO:0007616)3.94234895
35proline transport (GO:0015824)3.91440755
36glutamate receptor signaling pathway (GO:0007215)3.91165645
37positive regulation of membrane potential (GO:0045838)3.90898908
38neuromuscular process controlling balance (GO:0050885)3.90492155
39neurotransmitter-gated ion channel clustering (GO:0072578)3.90124657
40glycine transport (GO:0015816)3.90028070
41neuron-neuron synaptic transmission (GO:0007270)3.81726667
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78227034
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75115544
44neuromuscular process controlling posture (GO:0050884)3.74924941
45activation of protein kinase A activity (GO:0034199)3.68938497
46neurotransmitter transport (GO:0006836)3.68168931
47regulation of dendritic spine morphogenesis (GO:0061001)3.63045096
48regulation of synaptic plasticity (GO:0048167)3.60073257
49transmission of nerve impulse (GO:0019226)3.58854077
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57972184
51negative regulation of dendrite morphogenesis (GO:0050774)3.57438650
52L-amino acid import (GO:0043092)3.54788046
53cerebellar Purkinje cell differentiation (GO:0021702)3.54311371
54regulation of postsynaptic membrane potential (GO:0060078)3.54281589
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47447169
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.45062378
57auditory behavior (GO:0031223)3.42807082
58regulation of neurotransmitter secretion (GO:0046928)3.42174380
59regulation of neurotransmitter levels (GO:0001505)3.41226705
60regulation of synapse maturation (GO:0090128)3.40682829
61neuronal ion channel clustering (GO:0045161)3.40480016
62cell communication by electrical coupling (GO:0010644)3.37559414
63response to auditory stimulus (GO:0010996)3.36221026
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35321011
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34967763
66prepulse inhibition (GO:0060134)3.34329141
67membrane depolarization during action potential (GO:0086010)3.33618319
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.28327261
69dendrite morphogenesis (GO:0048813)3.27963604
70synaptic vesicle endocytosis (GO:0048488)3.27545659
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26276237
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.25635598
73regulation of ARF protein signal transduction (GO:0032012)3.24616110
74cytoskeletal anchoring at plasma membrane (GO:0007016)3.23525089
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20874436
76regulation of neurotransmitter transport (GO:0051588)3.20590371
77neuromuscular synaptic transmission (GO:0007274)3.19716046
78acidic amino acid transport (GO:0015800)3.19421688
79neuron recognition (GO:0008038)3.18597455
80membrane hyperpolarization (GO:0060081)3.18541395
81vesicle transport along microtubule (GO:0047496)3.17569716
82membrane depolarization (GO:0051899)3.17341798
83presynaptic membrane organization (GO:0097090)3.16323432
84neuromuscular process (GO:0050905)3.15860760
85long-term synaptic potentiation (GO:0060291)3.15684071
86positive regulation of neurotransmitter transport (GO:0051590)3.14383709
87potassium ion import (GO:0010107)3.14021979
88regulation of vesicle fusion (GO:0031338)3.13148813
89dendritic spine organization (GO:0097061)3.09643497
90positive regulation of synapse maturation (GO:0090129)3.08540192
91presynaptic membrane assembly (GO:0097105)3.07204652
92vesicle docking involved in exocytosis (GO:0006904)3.06269916
93regulation of dendritic spine development (GO:0060998)3.05266564
94positive regulation of neurotransmitter secretion (GO:0001956)3.04911304
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03470995
96adult walking behavior (GO:0007628)3.03390341
97neurotransmitter uptake (GO:0001504)3.02230219
98gamma-aminobutyric acid signaling pathway (GO:0007214)3.02037259
99positive regulation of dendritic spine development (GO:0060999)3.01670849
100negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01325148
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00308801
102axonal fasciculation (GO:0007413)3.00116536
103cell differentiation in hindbrain (GO:0021533)2.99249109
104learning (GO:0007612)2.98003875
105detection of calcium ion (GO:0005513)2.97157561
106regulation of synaptic transmission (GO:0050804)2.97095821
107postsynaptic membrane organization (GO:0001941)2.95513089
108positive regulation of synaptic transmission (GO:0050806)2.94167780
109chemosensory behavior (GO:0007635)2.93857773
110cerebellar Purkinje cell layer development (GO:0021680)2.93060211
111mating behavior (GO:0007617)2.93004079
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92970966
113regulation of voltage-gated calcium channel activity (GO:1901385)2.92858681
114synaptic vesicle transport (GO:0048489)2.92312517
115establishment of synaptic vesicle localization (GO:0097480)2.92312517
116potassium ion homeostasis (GO:0055075)2.90879491
117cellular sodium ion homeostasis (GO:0006883)2.90529604
118synaptic transmission (GO:0007268)2.89967372
119vesicle docking (GO:0048278)2.89095142
120innervation (GO:0060384)2.87616842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79132650
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09423999
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06734053
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05315204
5GBX2_23144817_ChIP-Seq_PC3_Human3.01470896
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.84084038
7DROSHA_22980978_ChIP-Seq_HELA_Human2.82764856
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81435434
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81435434
10REST_21632747_ChIP-Seq_MESCs_Mouse2.71022004
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67957041
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60465378
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58251080
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54266479
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45337576
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44604821
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40555559
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31890453
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31311632
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29802244
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.25262881
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24783769
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.22363023
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.18057262
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17845798
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15221518
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93123554
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89284215
29AR_21572438_ChIP-Seq_LNCaP_Human1.83282525
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78200847
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.71372834
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49708155
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47915798
34SMAD4_21799915_ChIP-Seq_A2780_Human1.45498145
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41395693
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41015886
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39623894
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38002141
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.35799900
40* KDM2B_26808549_Chip-Seq_K562_Human1.33941059
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.33669966
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28154032
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26035467
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25965407
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.24080560
46TAF15_26573619_Chip-Seq_HEK293_Human1.24021789
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23297615
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23088846
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22725575
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22029258
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21743597
52AR_19668381_ChIP-Seq_PC3_Human1.21690666
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20512723
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20279982
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19532435
56ZNF274_21170338_ChIP-Seq_K562_Hela1.18747712
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.14837351
58STAT3_23295773_ChIP-Seq_U87_Human1.14550903
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14288334
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.13149622
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.11008937
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10396597
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07748656
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07224484
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06948935
66* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06244297
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05699932
68AR_25329375_ChIP-Seq_VCAP_Human1.04686509
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04337149
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.03699408
71RNF2_27304074_Chip-Seq_NSC_Mouse1.02707777
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02510001
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02129425
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01371399
75P300_19829295_ChIP-Seq_ESCs_Human1.00486401
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.99149447
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98025616
78ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97631163
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97100762
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96870696
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96774002
82* TCF4_23295773_ChIP-Seq_U87_Human0.96482815
83AHR_22903824_ChIP-Seq_MCF-7_Human0.96381581
84TET1_21490601_ChIP-Seq_MESCs_Mouse0.95715770
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94833770
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94766782
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.94755121
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.94360055
89CTCF_27219007_Chip-Seq_Bcells_Human0.94201496
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94064384
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.93975474
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.91987683
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.91981399
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.91131264
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.90544435
96TP53_16413492_ChIP-PET_HCT116_Human0.90487702
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90416917
98RXR_22108803_ChIP-Seq_LS180_Human0.89886312
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89625961
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.88077746
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87613675
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87285440
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87118491
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86391233
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.84973684
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84968559
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84143411
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83870452
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83843113
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83630451
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83289609
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.83071787
113KLF4_19829295_ChIP-Seq_ESCs_Human0.82611470
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81405223
115DPY_21335234_ChIP-Seq_ESCs_Mouse0.81341060
116RUNX2_22187159_ChIP-Seq_PCA_Human0.81110024
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80367041
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79946766
119LXR_22292898_ChIP-Seq_THP-1_Human0.79499115
120SOX9_26525672_Chip-Seq_HEART_Mouse0.77308918
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76681317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.05534881
2MP0003880_abnormal_central_pattern4.61140576
3MP0003635_abnormal_synaptic_transmissio4.25096812
4MP0004270_analgesia4.07555417
5MP0009745_abnormal_behavioral_response3.46649866
6MP0009046_muscle_twitch3.29936778
7MP0002063_abnormal_learning/memory/cond3.29230192
8MP0002064_seizures3.26904211
9MP0002822_catalepsy3.18219371
10MP0001968_abnormal_touch/_nociception3.06569344
11MP0005423_abnormal_somatic_nervous2.99672357
12MP0002734_abnormal_mechanical_nocicepti2.77880008
13MP0002272_abnormal_nervous_system2.76506037
14MP0002572_abnormal_emotion/affect_behav2.69813878
15MP0001486_abnormal_startle_reflex2.69361933
16MP0002736_abnormal_nociception_after2.23698183
17MP0001501_abnormal_sleep_pattern2.23317552
18MP0002735_abnormal_chemical_nociception2.23281103
19MP0008569_lethality_at_weaning2.16073934
20MP0002733_abnormal_thermal_nociception2.10194028
21MP0004858_abnormal_nervous_system2.05449228
22MP0001970_abnormal_pain_threshold2.04186306
23MP0003329_amyloid_beta_deposits2.02043538
24MP0001440_abnormal_grooming_behavior1.95858218
25MP0009780_abnormal_chondrocyte_physiolo1.93087763
26MP0002067_abnormal_sensory_capabilities1.92451446
27MP0004811_abnormal_neuron_physiology1.88116037
28MP0002909_abnormal_adrenal_gland1.73962720
29MP0002184_abnormal_innervation1.69563769
30MP0004885_abnormal_endolymph1.66147566
31MP0000955_abnormal_spinal_cord1.65870632
32MP0005386_behavior/neurological_phenoty1.65487284
33MP0004924_abnormal_behavior1.65487284
34MP0002557_abnormal_social/conspecific_i1.63728114
35MP0000778_abnormal_nervous_system1.63032977
36MP0003879_abnormal_hair_cell1.54850521
37MP0003633_abnormal_nervous_system1.53708572
38MP0005646_abnormal_pituitary_gland1.52768201
39MP0002066_abnormal_motor_capabilities/c1.46662680
40MP0002882_abnormal_neuron_morphology1.43397739
41MP0000920_abnormal_myelination1.33775531
42MP0006276_abnormal_autonomic_nervous1.31709549
43MP0004142_abnormal_muscle_tone1.31269615
44MP0003631_nervous_system_phenotype1.28539008
45MP0003690_abnormal_glial_cell1.26702245
46MP0001984_abnormal_olfaction1.24123482
47MP0003787_abnormal_imprinting1.22702334
48MP0005645_abnormal_hypothalamus_physiol1.18149334
49MP0003283_abnormal_digestive_organ1.14659773
50MP0003123_paternal_imprinting1.14161389
51MP0003075_altered_response_to1.11751834
52MP0000751_myopathy1.10137983
53MP0001905_abnormal_dopamine_level1.09958535
54MP0001502_abnormal_circadian_rhythm1.08437360
55MP0002229_neurodegeneration1.07511161
56MP0001529_abnormal_vocalization1.06993413
57MP0002152_abnormal_brain_morphology1.06303498
58MP0004145_abnormal_muscle_electrophysio1.05789739
59MP0000569_abnormal_digit_pigmentation1.05441909
60MP0001177_atelectasis1.05279655
61MP0008872_abnormal_physiological_respon1.04482161
62MP0003634_abnormal_glial_cell1.02580748
63MP0008874_decreased_physiological_sensi1.01268032
64MP0003632_abnormal_nervous_system0.95096658
65MP0000604_amyloidosis0.91435141
66MP0008961_abnormal_basal_metabolism0.89722518
67MP0002069_abnormal_eating/drinking_beha0.89435165
68MP0004742_abnormal_vestibular_system0.88839312
69MP0000013_abnormal_adipose_tissue0.88388951
70MP0003122_maternal_imprinting0.88161046
71MP0005623_abnormal_meninges_morphology0.87941570
72MP0005167_abnormal_blood-brain_barrier0.84956770
73MP0001958_emphysema0.81517125
74MP0004085_abnormal_heartbeat0.80828084
75MP0001485_abnormal_pinna_reflex0.77121890
76MP0005535_abnormal_body_temperature0.76194584
77MP0001299_abnormal_eye_distance/0.75607206
78MP0004147_increased_porphyrin_level0.74819609
79MP0001963_abnormal_hearing_physiology0.74124518
80MP0002638_abnormal_pupillary_reflex0.72908196
81MP0005409_darkened_coat_color0.72777070
82MP0001346_abnormal_lacrimal_gland0.71616744
83MP0003172_abnormal_lysosome_physiology0.71554383
84MP0005551_abnormal_eye_electrophysiolog0.70315943
85MP0003137_abnormal_impulse_conducting0.70207985
86MP0002752_abnormal_somatic_nervous0.69240885
87MP0001986_abnormal_taste_sensitivity0.65647002
88MP0002090_abnormal_vision0.65320634
89MP0008438_abnormal_cutaneous_collagen0.64641671
90MP0001188_hyperpigmentation0.63878047
91MP0005499_abnormal_olfactory_system0.63699347
92MP0005394_taste/olfaction_phenotype0.63699347
93MP0000747_muscle_weakness0.61882226
94MP0004510_myositis0.59878107
95MP0004130_abnormal_muscle_cell0.59327286
96MP0004043_abnormal_pH_regulation0.58759868
97MP0001348_abnormal_lacrimal_gland0.58138318
98MP0010386_abnormal_urinary_bladder0.58113149
99MP0003861_abnormal_nervous_system0.57037763
100MP0004233_abnormal_muscle_weight0.56898540
101MP0002295_abnormal_pulmonary_circulatio0.56846238
102MP0004215_abnormal_myocardial_fiber0.56801268
103MP0003279_aneurysm0.55517954
104MP0002082_postnatal_lethality0.54923394
105MP0004484_altered_response_of0.54453568
106MP0000631_abnormal_neuroendocrine_gland0.54070510
107MP0010769_abnormal_survival0.54067060
108MP0001943_abnormal_respiration0.53960519
109MP0001664_abnormal_digestion0.53456975
110MP0003705_abnormal_hypodermis_morpholog0.53308530
111MP0003045_fibrosis0.53258891
112MP0010768_mortality/aging0.50146252
113MP0010770_preweaning_lethality0.49817781
114MP0002133_abnormal_respiratory_system0.49411716
115MP0005388_respiratory_system_phenotype0.49411716

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.85774899
2Focal motor seizures (HP:0011153)7.24000268
3Focal seizures (HP:0007359)5.68250486
4Visual hallucinations (HP:0002367)5.02603608
5Action tremor (HP:0002345)4.82042702
6Progressive cerebellar ataxia (HP:0002073)4.37055317
7Epileptic encephalopathy (HP:0200134)4.21835182
8Atonic seizures (HP:0010819)4.20698788
9Supranuclear gaze palsy (HP:0000605)4.20249962
10Ankle clonus (HP:0011448)4.17121885
11Febrile seizures (HP:0002373)4.06615695
12Absence seizures (HP:0002121)3.75058361
13Generalized tonic-clonic seizures (HP:0002069)3.71176641
14Impaired vibration sensation in the lower limbs (HP:0002166)3.51178306
15Gaze-evoked nystagmus (HP:0000640)3.46691136
16Urinary bladder sphincter dysfunction (HP:0002839)3.45711482
17Dysmetria (HP:0001310)3.42791439
18Dialeptic seizures (HP:0011146)3.42236930
19Depression (HP:0000716)3.41357736
20Poor eye contact (HP:0000817)3.38021996
21Papilledema (HP:0001085)3.35722094
22Dysdiadochokinesis (HP:0002075)3.34440439
23Postural instability (HP:0002172)3.33038735
24Broad-based gait (HP:0002136)3.22664604
25Mutism (HP:0002300)3.09555676
26Abnormal social behavior (HP:0012433)3.09233988
27Impaired social interactions (HP:0000735)3.09233988
28Anxiety (HP:0000739)3.08240736
29Intention tremor (HP:0002080)3.06319481
30Urinary urgency (HP:0000012)3.04792286
31Spastic gait (HP:0002064)3.03984249
32Truncal ataxia (HP:0002078)3.03574674
33Cerebral hypomyelination (HP:0006808)2.98541327
34Torticollis (HP:0000473)2.95339744
35Abnormal eating behavior (HP:0100738)2.95139829
36Scanning speech (HP:0002168)2.94058172
37Ventricular fibrillation (HP:0001663)2.88486391
38Hemiplegia (HP:0002301)2.84476167
39Neurofibrillary tangles (HP:0002185)2.83846471
40Abnormality of the lower motor neuron (HP:0002366)2.81581945
41Akinesia (HP:0002304)2.79869267
42Genetic anticipation (HP:0003743)2.76081255
43Impaired smooth pursuit (HP:0007772)2.72357172
44Termporal pattern (HP:0011008)2.70661742
45Insidious onset (HP:0003587)2.70661742
46Focal dystonia (HP:0004373)2.67751390
47Annular pancreas (HP:0001734)2.65001467
48Megalencephaly (HP:0001355)2.56639023
49Sleep apnea (HP:0010535)2.55757469
50Amblyopia (HP:0000646)2.54110249
51Bradykinesia (HP:0002067)2.51048985
52Cerebral inclusion bodies (HP:0100314)2.49880995
53Abnormality of the corticospinal tract (HP:0002492)2.48989439
54Insomnia (HP:0100785)2.48592400
55Hemiparesis (HP:0001269)2.48521627
56Lower limb muscle weakness (HP:0007340)2.48169173
57Progressive inability to walk (HP:0002505)2.42622197
58Pheochromocytoma (HP:0002666)2.41693093
59Craniofacial dystonia (HP:0012179)2.41287781
60Dysmetric saccades (HP:0000641)2.41045539
61Impaired vibratory sensation (HP:0002495)2.40163314
62Stereotypic behavior (HP:0000733)2.39821952
63Abnormality of ocular smooth pursuit (HP:0000617)2.37914361
64Delusions (HP:0000746)2.36157019
65Pointed chin (HP:0000307)2.35408119
66Diplopia (HP:0000651)2.32708976
67Abnormality of binocular vision (HP:0011514)2.32708976
68Clonus (HP:0002169)2.30900442
69Bundle branch block (HP:0011710)2.29320316
70Status epilepticus (HP:0002133)2.19202853
71Fetal akinesia sequence (HP:0001989)2.18432940
72Drooling (HP:0002307)2.16295357
73Excessive salivation (HP:0003781)2.16295357
74Hyperventilation (HP:0002883)2.16123952
75Abnormality of saccadic eye movements (HP:0000570)2.12162504
76Apathy (HP:0000741)2.10924961
77Distal upper limb amyotrophy (HP:0007149)2.10897525
78Upper limb amyotrophy (HP:0009129)2.10897525
79Lower limb amyotrophy (HP:0007210)2.09789377
80Peripheral hypomyelination (HP:0007182)2.08036376
81Hand muscle atrophy (HP:0009130)2.07778393
82Neuronal loss in central nervous system (HP:0002529)2.02340649
83Resting tremor (HP:0002322)2.01562616
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01355909
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.01355909
86Generalized myoclonic seizures (HP:0002123)2.00791511
87Neuroendocrine neoplasm (HP:0100634)1.99936079
88Epileptiform EEG discharges (HP:0011182)1.99734284
89Onion bulb formation (HP:0003383)1.99703454
90Spastic tetraparesis (HP:0001285)1.99157157
91Abnormal EKG (HP:0003115)1.97077376
92Aplasia involving bones of the extremities (HP:0009825)1.96896422
93Aplasia involving bones of the upper limbs (HP:0009823)1.96896422
94Aplasia of the phalanges of the hand (HP:0009802)1.96896422
95EEG with generalized epileptiform discharges (HP:0011198)1.96256515
96Obstructive sleep apnea (HP:0002870)1.95059739
97Gait ataxia (HP:0002066)1.94233936
98Agitation (HP:0000713)1.92922408
99Incomplete penetrance (HP:0003829)1.92627100
100Hammertoe (HP:0001765)1.92623852
101Rigidity (HP:0002063)1.92577926
102Absent speech (HP:0001344)1.91739761
103Hypsarrhythmia (HP:0002521)1.91076898
104Rapidly progressive (HP:0003678)1.89934710
105Limb dystonia (HP:0002451)1.88987496
106Ankyloglossia (HP:0010296)1.88030998
107Diminished motivation (HP:0000745)1.84839729
108Polyphagia (HP:0002591)1.84662313
109Spinal canal stenosis (HP:0003416)1.83536326
110Tetraplegia (HP:0002445)1.83299514
111Mild short stature (HP:0003502)1.83266827
112Hypoventilation (HP:0002791)1.83185496
113Choreoathetosis (HP:0001266)1.81874344
114CNS hypomyelination (HP:0003429)1.81867505
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80959382
116Prolonged QT interval (HP:0001657)1.78980013
117Lower limb asymmetry (HP:0100559)1.78728682
118Neoplasm of the peripheral nervous system (HP:0100007)1.76992893
119Turricephaly (HP:0000262)1.76912109
120Postural tremor (HP:0002174)1.76323648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.37889970
2EPHA44.22562679
3MAP3K94.09572032
4MINK12.83133691
5MAP3K42.66870488
6MARK12.62867933
7PAK62.61604404
8PRKD32.60355671
9DAPK22.51849611
10NTRK12.40485806
11KSR22.36076305
12CAMKK12.18003191
13NTRK22.12555275
14MAP2K72.05191400
15MAP2K41.69832125
16RIPK41.69106636
17STK381.66113467
18CDK51.63668777
19TNIK1.55758679
20CDK191.37524395
21TYRO31.34934028
22MAP3K21.34850201
23MAP3K121.34502089
24KSR11.30662903
25FES1.29541752
26PRPF4B1.29038625
27UHMK11.28729402
28ARAF1.28099768
29TAOK11.27999347
30DAPK11.27651601
31LMTK21.25301725
32GRK51.21300360
33LATS21.20051536
34MAP3K131.15352991
35MAPK131.12516732
36CAMKK21.12365466
37PRKCG1.11896089
38SIK21.11151878
39PHKG11.09698925
40PHKG21.09698925
41PRKCH1.07493675
42LIMK11.06210246
43ALK1.04829726
44CAMK11.02640851
45SGK2231.02358174
46SGK4941.02358174
47STK111.01674186
48RET0.98665208
49PNCK0.97643790
50PINK10.96964298
51PLK20.96159634
52WNK10.95989044
53CDK150.93713215
54CDK180.92551225
55OXSR10.91146258
56CDK140.89845808
57CAMK2A0.86273950
58PAK30.83452541
59CDK11A0.81985633
60TNK20.80966316
61RIPK10.80454674
62PKN10.78838843
63CASK0.77868777
64MAPK120.77615024
65MARK20.77077013
66PDK10.77059483
67RAF10.75461014
68SGK30.75165708
69PDPK10.74429035
70CAMK2B0.73080372
71SGK20.70845552
72MAP3K10.68642824
73NEK60.67966958
74SGK10.66282924
75STK390.65409832
76CDC42BPA0.63831000
77PDGFRA0.62254725
78PTK2B0.61833335
79TESK10.60325341
80BRSK10.57984196
81CSNK1G20.56567486
82MAP3K70.56027309
83ROCK10.55262003
84SCYL20.54340611
85FYN0.52628943
86* RPS6KA30.52073595
87NEK10.51976532
88CAMK1G0.51922540
89MAPK100.51913860
90PAK20.49735163
91CAMK2G0.49675935
92DYRK1A0.48992277
93PRKCZ0.47298951
94BMPR20.46986604
95CAMK2D0.46672920
96DMPK0.46515790
97BRAF0.46393395
98CAMK40.46088090
99ROCK20.44407035
100DAPK30.42544389
101DDR20.42299387
102MAP3K110.42214605
103FGFR20.39416109
104MAPKAPK50.39334309
105FER0.38755284
106MAP2K10.38752760
107PRKCE0.38023955
108MOS0.37456001
109PTK20.36972689
110PRKG10.34979829
111PRKCA0.33819242
112CCNB10.33142908
113BMX0.33106286
114ICK0.32787437
115PRKG20.30810046

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28592981
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19888560
3Olfactory transduction_Homo sapiens_hsa047402.86820145
4Circadian entrainment_Homo sapiens_hsa047132.65330282
5GABAergic synapse_Homo sapiens_hsa047272.65229978
6Glutamatergic synapse_Homo sapiens_hsa047242.56636916
7Long-term potentiation_Homo sapiens_hsa047202.54984622
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44680061
9Morphine addiction_Homo sapiens_hsa050322.39929628
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38567619
11Amphetamine addiction_Homo sapiens_hsa050312.30028003
12Salivary secretion_Homo sapiens_hsa049702.22503070
13Dopaminergic synapse_Homo sapiens_hsa047282.07431005
14Gastric acid secretion_Homo sapiens_hsa049712.02113390
15Insulin secretion_Homo sapiens_hsa049112.00695395
16Cholinergic synapse_Homo sapiens_hsa047251.93742343
17Nitrogen metabolism_Homo sapiens_hsa009101.91639382
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88707116
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77543971
20Oxytocin signaling pathway_Homo sapiens_hsa049211.63017909
21Long-term depression_Homo sapiens_hsa047301.61285304
22Cocaine addiction_Homo sapiens_hsa050301.60045986
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59446807
24Taste transduction_Homo sapiens_hsa047421.57799084
25Renin secretion_Homo sapiens_hsa049241.56955626
26Calcium signaling pathway_Homo sapiens_hsa040201.53785641
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51007145
28GnRH signaling pathway_Homo sapiens_hsa049121.50253459
29Serotonergic synapse_Homo sapiens_hsa047261.46725781
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40931824
31Gap junction_Homo sapiens_hsa045401.36208096
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35619094
33cAMP signaling pathway_Homo sapiens_hsa040241.30859249
34Type II diabetes mellitus_Homo sapiens_hsa049301.25795533
35Vitamin B6 metabolism_Homo sapiens_hsa007501.24062565
36Glioma_Homo sapiens_hsa052141.21753630
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20921671
38Estrogen signaling pathway_Homo sapiens_hsa049151.16744953
39ErbB signaling pathway_Homo sapiens_hsa040121.08289581
40Axon guidance_Homo sapiens_hsa043601.07826207
41Melanogenesis_Homo sapiens_hsa049161.03277581
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02656685
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00811773
44Dorso-ventral axis formation_Homo sapiens_hsa043201.00196366
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00195861
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.94935342
47Collecting duct acid secretion_Homo sapiens_hsa049660.93440685
48Pancreatic secretion_Homo sapiens_hsa049720.93105551
49Oocyte meiosis_Homo sapiens_hsa041140.88383640
50Cardiac muscle contraction_Homo sapiens_hsa042600.87225219
51Thyroid hormone synthesis_Homo sapiens_hsa049180.85118434
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82487087
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82062496
54Dilated cardiomyopathy_Homo sapiens_hsa054140.79408112
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75651321
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75349954
57Choline metabolism in cancer_Homo sapiens_hsa052310.75314109
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73365751
59MAPK signaling pathway_Homo sapiens_hsa040100.72578745
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.72199791
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70937647
62Endocytosis_Homo sapiens_hsa041440.66807675
63Bile secretion_Homo sapiens_hsa049760.66737627
64VEGF signaling pathway_Homo sapiens_hsa043700.65175240
65Vibrio cholerae infection_Homo sapiens_hsa051100.63580795
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.62695825
67Rap1 signaling pathway_Homo sapiens_hsa040150.62499523
68Ras signaling pathway_Homo sapiens_hsa040140.60815812
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58790553
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57086448
71Phototransduction_Homo sapiens_hsa047440.56447459
72mTOR signaling pathway_Homo sapiens_hsa041500.55539177
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53550489
74Inositol phosphate metabolism_Homo sapiens_hsa005620.52578522
75Glucagon signaling pathway_Homo sapiens_hsa049220.50747748
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49928759
77Non-small cell lung cancer_Homo sapiens_hsa052230.48728019
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48683651
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46986356
80Alcoholism_Homo sapiens_hsa050340.46544585
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46185606
82Type I diabetes mellitus_Homo sapiens_hsa049400.45054946
83Prion diseases_Homo sapiens_hsa050200.44876058
84Endometrial cancer_Homo sapiens_hsa052130.44248439
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44030115
86Renal cell carcinoma_Homo sapiens_hsa052110.43527041
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42159718
88Insulin signaling pathway_Homo sapiens_hsa049100.42153276
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41542397
90Ovarian steroidogenesis_Homo sapiens_hsa049130.40804404
91Chemokine signaling pathway_Homo sapiens_hsa040620.40103148
92Focal adhesion_Homo sapiens_hsa045100.40025026
93Hippo signaling pathway_Homo sapiens_hsa043900.38424186
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38383843
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38053910
96Wnt signaling pathway_Homo sapiens_hsa043100.37892489
97ECM-receptor interaction_Homo sapiens_hsa045120.37703340
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35016901
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33626479
100Protein digestion and absorption_Homo sapiens_hsa049740.32857933
101Arginine and proline metabolism_Homo sapiens_hsa003300.32791968
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.32574189
103Circadian rhythm_Homo sapiens_hsa047100.31318663
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31302282
105Platelet activation_Homo sapiens_hsa046110.30985717
106Tight junction_Homo sapiens_hsa045300.30612705
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30446632
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27475281
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27349072
110Mineral absorption_Homo sapiens_hsa049780.27141844
111AMPK signaling pathway_Homo sapiens_hsa041520.26359642
112Histidine metabolism_Homo sapiens_hsa003400.25832906

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