MAP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.11306220
2fusion of sperm to egg plasma membrane (GO:0007342)7.59362701
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.15906721
4axonemal dynein complex assembly (GO:0070286)7.11963871
5epithelial cilium movement (GO:0003351)6.98265645
6piRNA metabolic process (GO:0034587)6.78755511
7cell wall macromolecule catabolic process (GO:0016998)6.60497313
8cell wall macromolecule metabolic process (GO:0044036)6.60497313
9sperm-egg recognition (GO:0035036)6.51768252
10sperm motility (GO:0030317)6.32058503
11motile cilium assembly (GO:0044458)6.20363671
12acrosome reaction (GO:0007340)6.09824579
13cilium movement (GO:0003341)6.05001551
14binding of sperm to zona pellucida (GO:0007339)6.03053838
15male meiosis (GO:0007140)5.84639691
16synaptonemal complex organization (GO:0070193)5.77755590
17acrosome assembly (GO:0001675)5.72440477
18multicellular organism reproduction (GO:0032504)5.70450610
19cell-cell recognition (GO:0009988)5.69363569
20synaptonemal complex assembly (GO:0007130)5.61052592
21plasma membrane fusion (GO:0045026)5.60562447
22positive regulation of B cell differentiation (GO:0045579)5.49016979
23spermatid development (GO:0007286)5.43570644
24regulation of cilium movement (GO:0003352)5.28042746
25autophagic vacuole fusion (GO:0000046)5.08918525
26aggressive behavior (GO:0002118)5.00732138
27reproduction (GO:0000003)4.75357780
28DNA methylation involved in gamete generation (GO:0043046)4.51561928
29purine deoxyribonucleotide catabolic process (GO:0009155)4.40508632
30establishment of apical/basal cell polarity (GO:0035089)4.34936415
31microtubule depolymerization (GO:0007019)4.28839528
32female mating behavior (GO:0060180)4.11633836
33nuclear pore organization (GO:0006999)4.05312710
34regulation of transmission of nerve impulse (GO:0051969)4.05147785
35nuclear pore complex assembly (GO:0051292)4.01976885
36male meiosis I (GO:0007141)3.98527625
37chromosome organization involved in meiosis (GO:0070192)3.98436799
38meiotic nuclear division (GO:0007126)3.96054634
39regulation of B cell differentiation (GO:0045577)3.95311970
40base-excision repair, AP site formation (GO:0006285)3.94017276
41regulation of female receptivity (GO:0045924)3.94006273
42left/right pattern formation (GO:0060972)3.93875492
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.91730546
44establishment of monopolar cell polarity (GO:0061162)3.91730546
45histamine secretion (GO:0001821)3.88411374
46positive regulation of amino acid transport (GO:0051957)3.84440858
47grooming behavior (GO:0007625)3.82426811
48single fertilization (GO:0007338)3.79054692
49sperm capacitation (GO:0048240)3.78967101
50negative regulation of inclusion body assembly (GO:0090084)3.76252451
51spermatogenesis (GO:0007283)3.74513842
52male gamete generation (GO:0048232)3.73805176
53purine nucleotide salvage (GO:0032261)3.72697851
54negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.72278570
55ventricular system development (GO:0021591)3.71344785
56mature B cell differentiation involved in immune response (GO:0002313)3.70816410
57regulation of microtubule-based movement (GO:0060632)3.70761395
58hyperosmotic salinity response (GO:0042538)3.68056832
59negative regulation of necrotic cell death (GO:0060547)3.67640529
60microtubule severing (GO:0051013)3.62415864
61organelle membrane fusion (GO:0090174)3.61922863
62aerobic respiration (GO:0009060)3.60944017
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.59933597
64membrane budding (GO:0006900)3.58274909
65definitive hemopoiesis (GO:0060216)3.58135889
66tryptophan catabolic process (GO:0006569)3.57389046
67indole-containing compound catabolic process (GO:0042436)3.57389046
68indolalkylamine catabolic process (GO:0046218)3.57389046
69regulation of hexokinase activity (GO:1903299)3.53903661
70regulation of glucokinase activity (GO:0033131)3.53903661
71DNA replication-dependent nucleosome organization (GO:0034723)3.53438757
72DNA replication-dependent nucleosome assembly (GO:0006335)3.53438757
73rRNA catabolic process (GO:0016075)3.52382493
74carnitine shuttle (GO:0006853)3.52358896
75regulation of germinal center formation (GO:0002634)3.52186110
76meiotic cell cycle (GO:0051321)3.49499484
77meiosis I (GO:0007127)3.47814980
78regulation of meiosis I (GO:0060631)3.47794483
79gene silencing by RNA (GO:0031047)3.47142148
80GPI anchor biosynthetic process (GO:0006506)3.45778804
81fertilization (GO:0009566)3.45652042
82gamete generation (GO:0007276)3.43813463
83monoubiquitinated protein deubiquitination (GO:0035520)3.41281758
84deoxyribonucleotide catabolic process (GO:0009264)3.39509437
85negative regulation of phagocytosis (GO:0050765)3.38031585
86histamine transport (GO:0051608)3.37514939
87germ cell development (GO:0007281)3.36291612
88tryptophan metabolic process (GO:0006568)3.34611625
89cellular process involved in reproduction in multicellular organism (GO:0022412)3.34571459
90protein localization to chromosome, centromeric region (GO:0071459)3.32486830
91intraciliary transport (GO:0042073)3.30506221
92NAD biosynthetic process (GO:0009435)3.27763333
93seminiferous tubule development (GO:0072520)3.25276724
94negative regulation of cell size (GO:0045792)3.24875402
95cellular extravasation (GO:0045123)3.24510447
96deoxyribose phosphate catabolic process (GO:0046386)3.18978740
97maturation of 5.8S rRNA (GO:0000460)3.17274174
98regulation of relaxation of muscle (GO:1901077)3.16398836
99negative regulation of organelle assembly (GO:1902116)3.13999539
100regulation of feeding behavior (GO:0060259)3.11578315
101mannosylation (GO:0097502)3.11468804
102chaperone-mediated protein complex assembly (GO:0051131)3.10818668
103microglial cell activation (GO:0001774)3.10470393
104axoneme assembly (GO:0035082)3.10032260
105chromosome condensation (GO:0030261)3.09722272
106regulation of histone H3-K9 methylation (GO:0051570)3.09102145
107purine deoxyribonucleotide metabolic process (GO:0009151)3.06662336
108regulation of chromatin binding (GO:0035561)3.06271906
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05934535
110maternal behavior (GO:0042711)3.05158071
111regulation of B cell apoptotic process (GO:0002902)3.02164557
112positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.02160530
113carnitine transmembrane transport (GO:1902603)3.02132739
114sodium-independent organic anion transport (GO:0043252)3.01464316
115positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01339779
116spermatid nucleus differentiation (GO:0007289)3.01182975
117regulation of inclusion body assembly (GO:0090083)3.00860686
118deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99217320
119positive regulation of fatty acid biosynthetic process (GO:0045723)2.97340657
120nucleus organization (GO:0006997)2.96629243
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96291961
122cell recognition (GO:0008037)2.96043602
123protein polyglutamylation (GO:0018095)2.95730567
124DNA deamination (GO:0045006)2.94993400
125histone exchange (GO:0043486)2.91565341
126DNA packaging (GO:0006323)2.91558404
127pore complex assembly (GO:0046931)2.91501041
128hematopoietic stem cell proliferation (GO:0071425)2.90752025
129meiotic cell cycle process (GO:1903046)2.90521933
130cilium organization (GO:0044782)2.89966230
131mitochondrial calcium ion transport (GO:0006851)2.89955077
132GPI anchor metabolic process (GO:0006505)2.89539437
133localization within membrane (GO:0051668)2.88554940
134purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.87718430
135mature B cell differentiation (GO:0002335)2.87528571
136modulation by symbiont of host immune response (GO:0052553)2.87028068
137positive regulation by symbiont of host defense response (GO:0052509)2.87028068
138modulation by symbiont of host defense response (GO:0052031)2.87028068
139modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87028068
140modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87028068
141positive regulation by organism of defense response of other organism involved in symbiotic interact2.87028068
142benzene-containing compound metabolic process (GO:0042537)2.82582906
143protein localization to kinetochore (GO:0034501)2.81757620
144negative regulation of B cell apoptotic process (GO:0002903)2.79031412
145hemoglobin metabolic process (GO:0020027)2.77097813
146cilium morphogenesis (GO:0060271)2.76932502
147toxin transport (GO:1901998)2.76684008
148histone H4-K12 acetylation (GO:0043983)2.76463570
149microtubule-based movement (GO:0007018)2.76322530
150gene silencing (GO:0016458)2.75733708
151cilium assembly (GO:0042384)2.75222541
152pinocytosis (GO:0006907)2.75199319
153regulation of B cell receptor signaling pathway (GO:0050855)2.73674449
154translesion synthesis (GO:0019985)2.71428718
155G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.70864258
156spindle assembly involved in mitosis (GO:0090307)2.69917572
157fatty acid transmembrane transport (GO:1902001)2.69424851
158stress granule assembly (GO:0034063)2.68877875
159amino-acid betaine transport (GO:0015838)2.68457236
160carnitine transport (GO:0015879)2.68457236
161parental behavior (GO:0060746)2.66288918
162mitotic nuclear envelope disassembly (GO:0007077)2.66231373
163metallo-sulfur cluster assembly (GO:0031163)2.65004035
164iron-sulfur cluster assembly (GO:0016226)2.65004035
165glycerol ether metabolic process (GO:0006662)2.64659046
166phosphatidylglycerol biosynthetic process (GO:0006655)2.64379782
167negative regulation of response to food (GO:0032096)2.63893330
168negative regulation of appetite (GO:0032099)2.63893330
169mitotic sister chromatid cohesion (GO:0007064)2.63074159
170actin-myosin filament sliding (GO:0033275)2.62828721
171muscle filament sliding (GO:0030049)2.62828721
172multicellular organismal reproductive process (GO:0048609)2.62563786
173negative regulation of digestive system process (GO:0060457)2.61955348
174Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61309304
175negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.60955267
176negative regulation of histone methylation (GO:0031061)2.60419589
177drinking behavior (GO:0042756)2.59949325
178calcium ion-dependent exocytosis (GO:0017156)2.59937936
179pre-miRNA processing (GO:0031054)2.59436887
180regulation of necrotic cell death (GO:0010939)2.59324486
181peptidyl-arginine omega-N-methylation (GO:0035247)2.58281589
182protein localization to cilium (GO:0061512)2.56993560
183negative regulation of calcium ion transmembrane transport (GO:1903170)2.56852452
184negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.56852452
185B cell receptor signaling pathway (GO:0050853)2.56716925
186genitalia morphogenesis (GO:0035112)2.56079687
187regulation of spindle checkpoint (GO:0090231)2.55840914
188response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55484545
189response to host immune response (GO:0052572)2.55484545
190negative regulation of fibroblast apoptotic process (GO:2000270)2.55160694
191T cell migration (GO:0072678)2.54957605
192regulation of centriole replication (GO:0046599)2.54862232
193glycolytic process (GO:0006096)2.54479159
194regulation of chromosome segregation (GO:0051983)2.54188591
195cellular component assembly involved in morphogenesis (GO:0010927)2.53182654
196nuclear envelope disassembly (GO:0051081)2.51038352
197membrane disassembly (GO:0030397)2.51038352
198regulation of RNA export from nucleus (GO:0046831)2.48914894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.79012126
2E2F7_22180533_ChIP-Seq_HELA_Human4.25866440
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.18702439
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.81958835
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27345112
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25930128
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.04962308
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.97159264
9GATA1_22025678_ChIP-Seq_K562_Human2.68880194
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60640861
11SCL_19346495_ChIP-Seq_HPC-7_Human2.58499843
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.57952330
13VDR_21846776_ChIP-Seq_THP-1_Human2.54468075
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54078833
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48455438
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48319508
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.48061711
18EZH2_22144423_ChIP-Seq_EOC_Human2.47079965
19MYB_26560356_Chip-Seq_TH2_Human2.46980929
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44986978
21SPI1_23547873_ChIP-Seq_NB4_Human2.31874742
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27349766
23VDR_23849224_ChIP-Seq_CD4+_Human2.22592424
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20577826
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19801972
26GATA1_26923725_Chip-Seq_HPCs_Mouse2.19600245
27BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.14475626
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.14161657
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.11747056
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11115447
31MYB_26560356_Chip-Seq_TH1_Human1.96786600
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96433268
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94467800
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89034199
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88429522
36VDR_24763502_ChIP-Seq_THP-1_Human1.88341712
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.87244220
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84530822
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83744151
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.83512397
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81122983
42ZNF274_21170338_ChIP-Seq_K562_Hela1.80825491
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79255404
44CIITA_25753668_ChIP-Seq_RAJI_Human1.76459322
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73691429
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73361035
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73261995
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69127840
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68417229
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67077373
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63459457
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63458067
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61669416
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57906573
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57590672
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56269182
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52175864
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49263670
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48343190
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48240227
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47855233
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.47421110
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47250151
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.46717178
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45486389
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.45356496
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42278056
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.42154720
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.42043330
70FUS_26573619_Chip-Seq_HEK293_Human1.41451228
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40717048
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40143147
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39345186
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38605969
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37161603
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36904998
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34655930
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.33135190
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33033281
80GATA3_26560356_Chip-Seq_TH2_Human1.32115520
81XRN2_22483619_ChIP-Seq_HELA_Human1.31838979
82UTX_26944678_Chip-Seq_JUKART_Human1.27997686
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27083061
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27067472
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25923692
86TAF15_26573619_Chip-Seq_HEK293_Human1.25843524
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24899168
88IRF1_19129219_ChIP-ChIP_H3396_Human1.24254230
89GATA3_27048872_Chip-Seq_THYMUS_Human1.23237053
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22974005
91MAF_26560356_Chip-Seq_TH1_Human1.22437669
92AR_21909140_ChIP-Seq_LNCAP_Human1.21730396
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18828824
94RUNX_20019798_ChIP-Seq_JUKART_Human1.18424440
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17901439
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.15680316
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15021461
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14717760
99MYC_22102868_ChIP-Seq_BL_Human1.14362619
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14330642
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14223724
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13398925
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13181747
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13007040
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12397546
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11167894
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10296381
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09625833
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08603587
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.08603587
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08135037
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08049660
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.07999620
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07265927
115WDR5_24793694_ChIP-Seq_LNCAP_Human1.07236666
116FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07037053
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.06375403
118ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05384586
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05045046
120ERG_20517297_ChIP-Seq_VCAP_Human1.03964549
121KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03771869
122VDR_24787735_ChIP-Seq_THP-1_Human1.03681563
123BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03327573
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03274934
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02694842
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02633519
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02222876
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.01152162
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00733352
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00613959
131ER_23166858_ChIP-Seq_MCF-7_Human1.00500367
132GABP_17652178_ChIP-ChIP_JURKAT_Human0.99885793
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99038275
134GABP_19822575_ChIP-Seq_HepG2_Human0.98850778
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98528273
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98314177
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97229581
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95164264
139EST1_17652178_ChIP-ChIP_JURKAT_Human0.95010274
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94836450
141ELK1_19687146_ChIP-ChIP_HELA_Human0.94775110
142FOXP3_21729870_ChIP-Seq_TREG_Human0.94657653
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93515535
144SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93397536
145KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93028079
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92789586
147HTT_18923047_ChIP-ChIP_STHdh_Human0.92170459
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92141865
149IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91410475
150CBP_20019798_ChIP-Seq_JUKART_Human0.91410475
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91069324
152TFEB_21752829_ChIP-Seq_HELA_Human0.90932284
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90887993
154STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90805629
155P300_27268052_Chip-Seq_Bcells_Human0.89857597
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89394080
157SPI1_23127762_ChIP-Seq_K562_Human0.89134857
158GATA3_21867929_ChIP-Seq_CD8_Mouse0.88965401
159TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87306491
160POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86739453
161ETS1_20019798_ChIP-Seq_JURKAT_Human0.86202265
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86081709
163TTF2_22483619_ChIP-Seq_HELA_Human0.86075072
164VDR_22108803_ChIP-Seq_LS180_Human0.85307809
165CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84771497
166STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84669775
167NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84323806
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84306261
169THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84289765
170TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84260727
171KAP1_27257070_Chip-Seq_ESCs_Mouse0.83063280
172POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81781897
173RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81409915
174CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80373940
175SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79036312
176GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.79029427
177E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78696686
178CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78389659
179SOX9_26525672_Chip-Seq_HEART_Mouse0.77671761
180GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77539741
181SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77212228
182TP63_19390658_ChIP-ChIP_HaCaT_Human0.76718343
183KDM5A_27292631_Chip-Seq_BREAST_Human0.76687999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.03186222
2MP0005451_abnormal_body_composition5.15651838
3MP0002653_abnormal_ependyma_morphology4.28669428
4MP0008877_abnormal_DNA_methylation3.34714884
5MP0008057_abnormal_DNA_replication3.33700432
6MP0003698_abnormal_male_reproductive3.25267943
7MP0001929_abnormal_gametogenesis3.17390108
8MP0001835_abnormal_antigen_presentation3.12362855
9MP0004133_heterotaxia2.90751820
10MP0006072_abnormal_retinal_apoptosis2.87800003
11MP0003806_abnormal_nucleotide_metabolis2.86242678
12MP0005645_abnormal_hypothalamus_physiol2.81515205
13MP0002396_abnormal_hematopoietic_system2.70806134
14MP0008058_abnormal_DNA_repair2.62881973
15MP0002822_catalepsy2.42384233
16MP0009278_abnormal_bone_marrow2.41639199
17MP0002210_abnormal_sex_determination2.33864332
18MP0004233_abnormal_muscle_weight2.26221343
19MP0010094_abnormal_chromosome_stability2.25988807
20MP0005464_abnormal_platelet_physiology2.16605797
21MP0003283_abnormal_digestive_organ2.14770391
22MP0005397_hematopoietic_system_phenotyp2.12206529
23MP0001545_abnormal_hematopoietic_system2.12206529
24MP0001145_abnormal_male_reproductive2.11584943
25MP0005253_abnormal_eye_physiology2.07681119
26MP0005075_abnormal_melanosome_morpholog2.03367625
27MP0003693_abnormal_embryo_hatching1.96112170
28MP0002161_abnormal_fertility/fecundity1.91975508
29MP0000465_gastrointestinal_hemorrhage1.91174618
30MP0002138_abnormal_hepatobiliary_system1.88293942
31MP0005551_abnormal_eye_electrophysiolog1.88130455
32MP0005387_immune_system_phenotype1.85998327
33MP0001790_abnormal_immune_system1.85998327
34MP0002139_abnormal_hepatobiliary_system1.85553960
35MP0003111_abnormal_nucleus_morphology1.84368614
36MP0004808_abnormal_hematopoietic_stem1.84261951
37MP0003890_abnormal_embryonic-extraembry1.82445567
38MP0001293_anophthalmia1.77508997
39MP0002419_abnormal_innate_immunity1.75711995
40MP0009697_abnormal_copulation1.74642481
41MP0000653_abnormal_sex_gland1.70877786
42MP0002452_abnormal_antigen_presenting1.70466060
43MP0001800_abnormal_humoral_immune1.69328599
44MP0006036_abnormal_mitochondrial_physio1.68765893
45MP0003252_abnormal_bile_duct1.68163696
46MP0003077_abnormal_cell_cycle1.65659185
47MP0000685_abnormal_immune_system1.62740625
48MP0004957_abnormal_blastocyst_morpholog1.62371951
49MP0001819_abnormal_immune_cell1.60360177
50MP0004084_abnormal_cardiac_muscle1.58106271
51MP0002420_abnormal_adaptive_immunity1.56267355
52MP0002723_abnormal_immune_serum1.54939678
53MP0003436_decreased_susceptibility_to1.53801318
54MP0008995_early_reproductive_senescence1.53549074
55MP0005025_abnormal_response_to1.50800258
56MP0002269_muscular_atrophy1.49552140
57MP0003567_abnormal_fetal_cardiomyocyte1.48236683
58MP0003718_maternal_effect1.46558018
59MP0009840_abnormal_foam_cell1.46444049
60MP0005000_abnormal_immune_tolerance1.44463042
61MP0002084_abnormal_developmental_patter1.44367721
62MP0000716_abnormal_immune_system1.44302237
63MP0005391_vision/eye_phenotype1.43671701
64MP0002132_abnormal_respiratory_system1.43542685
65MP0002398_abnormal_bone_marrow1.41303039
66MP0002837_dystrophic_cardiac_calcinosis1.40784686
67MP0003011_delayed_dark_adaptation1.40389209
68MP0002106_abnormal_muscle_physiology1.40042478
69MP0005165_increased_susceptibility_to1.39412962
70MP0005058_abnormal_lysosome_morphology1.39068766
71MP0003950_abnormal_plasma_membrane1.38090665
72MP0000537_abnormal_urethra_morphology1.38089610
73MP0004484_altered_response_of1.33510362
74MP0006292_abnormal_olfactory_placode1.32018524
75MP0000631_abnormal_neuroendocrine_gland1.31930711
76MP0005623_abnormal_meninges_morphology1.30905698
77MP0002148_abnormal_hypersensitivity_rea1.30009557
78MP0002085_abnormal_embryonic_tissue1.29938632
79MP0003119_abnormal_digestive_system1.29153082
80MP0008004_abnormal_stomach_pH1.27912324
81MP0001730_embryonic_growth_arrest1.27373379
82MP0005670_abnormal_white_adipose1.26381128
83MP0000751_myopathy1.25296500
84MP0005076_abnormal_cell_differentiation1.23950307
85MP0002102_abnormal_ear_morphology1.22159978
86MP0002234_abnormal_pharynx_morphology1.21535774
87MP0001905_abnormal_dopamine_level1.20261463
88MP0001697_abnormal_embryo_size1.20105124
89MP0003172_abnormal_lysosome_physiology1.20062868
90MP0001986_abnormal_taste_sensitivity1.19306806
91MP0005671_abnormal_response_to1.18387507
92MP0000013_abnormal_adipose_tissue1.17100925
93MP0004197_abnormal_fetal_growth/weight/1.16793172
94MP0002332_abnormal_exercise_endurance1.16720767
95MP0005380_embryogenesis_phenotype1.15127171
96MP0001672_abnormal_embryogenesis/_devel1.15127171
97MP0005084_abnormal_gallbladder_morpholo1.14342052
98MP0003828_pulmonary_edema1.14020560
99MP0000689_abnormal_spleen_morphology1.13118322
100MP0002429_abnormal_blood_cell1.12169061
101MP0002722_abnormal_immune_system1.12139286
102MP0008932_abnormal_embryonic_tissue1.11508577
103MP0000462_abnormal_digestive_system1.11412649
104MP0003195_calcinosis1.10866975
105MP0002638_abnormal_pupillary_reflex1.10665435
106MP0006035_abnormal_mitochondrial_morpho1.10470236
107MP0004145_abnormal_muscle_electrophysio1.07601476
108MP0000350_abnormal_cell_proliferation1.07481011
109MP0003861_abnormal_nervous_system1.06086417
110MP0003137_abnormal_impulse_conducting1.06021790
111MP0000749_muscle_degeneration1.05575962
112MP0005666_abnormal_adipose_tissue1.05034599
113MP0003045_fibrosis1.04946978
114MP0009785_altered_susceptibility_to1.03650724
115MP0002282_abnormal_trachea_morphology1.03448818
116MP0002127_abnormal_cardiovascular_syste1.02788552
117MP0003984_embryonic_growth_retardation1.02654400
118MP0009703_decreased_birth_body1.01725873
119MP0003191_abnormal_cellular_cholesterol1.01317159
120MP0004215_abnormal_myocardial_fiber1.00460919
121MP0003303_peritoneal_inflammation0.99408813
122MP0002088_abnormal_embryonic_growth/wei0.99334025
123MP0005369_muscle_phenotype0.98125576
124MP0010155_abnormal_intestine_physiology0.97765499
125MP0002080_prenatal_lethality0.97326813
126MP0002019_abnormal_tumor_incidence0.97287958
127MP0002697_abnormal_eye_size0.97259914
128MP0003122_maternal_imprinting0.96596186
129MP0004036_abnormal_muscle_relaxation0.96459949
130MP0008007_abnormal_cellular_replicative0.95544065
131MP0003786_premature_aging0.95208248
132MP0005423_abnormal_somatic_nervous0.94881334
133MP0001324_abnormal_eye_pigmentation0.93602957
134MP0005195_abnormal_posterior_eye0.93295030
135MP0003942_abnormal_urinary_system0.92236915
136MP0003115_abnormal_respiratory_system0.91830783
137MP0003646_muscle_fatigue0.91639656
138MP0003075_altered_response_to0.91233752
139MP0002971_abnormal_brown_adipose0.89113515
140MP0000358_abnormal_cell_content/0.88659821
141MP0002160_abnormal_reproductive_system0.88151079
142MP0005334_abnormal_fat_pad0.87033019
143MP0005395_other_phenotype0.86272547
144MP0003123_paternal_imprinting0.85755510
145MP0005584_abnormal_enzyme/coenzyme_acti0.85541287
146MP0004134_abnormal_chest_morphology0.85391502
147MP0010307_abnormal_tumor_latency0.84201541
148MP0001727_abnormal_embryo_implantation0.83738441
149MP0005266_abnormal_metabolism0.83200902
150MP0000428_abnormal_craniofacial_morphol0.82927857
151MP0000759_abnormal_skeletal_muscle0.80897419
152MP0000703_abnormal_thymus_morphology0.80397613
153MP0009763_increased_sensitivity_to0.80248678
154MP0001764_abnormal_homeostasis0.79125533
155MP0009764_decreased_sensitivity_to0.77994584
156MP0003121_genomic_imprinting0.77556359
157MP0008873_increased_physiological_sensi0.76477864
158MP0008961_abnormal_basal_metabolism0.76466229
159MP0002092_abnormal_eye_morphology0.76273608
160MP0002152_abnormal_brain_morphology0.76272310
161MP0003638_abnormal_response/metabolism_0.76261141
162MP0009672_abnormal_birth_weight0.75215642
163MP0001845_abnormal_inflammatory_respons0.74908468
164MP0000778_abnormal_nervous_system0.74645042
165MP0000313_abnormal_cell_death0.74116243
166MP0002752_abnormal_somatic_nervous0.73808266
167MP0008469_abnormal_protein_level0.73056590
168MP0002086_abnormal_extraembryonic_tissu0.72773926
169MP0005330_cardiomyopathy0.71168300
170MP0001853_heart_inflammation0.70964423
171MP0000747_muscle_weakness0.70657057
172MP0003221_abnormal_cardiomyocyte_apopto0.70236765
173MP0003300_gastrointestinal_ulcer0.70052228
174MP0002229_neurodegeneration0.67299442
175MP0003634_abnormal_glial_cell0.66379593
176MP0005394_taste/olfaction_phenotype0.64181998
177MP0005499_abnormal_olfactory_system0.64181998
178MP0010030_abnormal_orbit_morphology0.62725800
179MP0010630_abnormal_cardiac_muscle0.62098926
180MP0005379_endocrine/exocrine_gland_phen0.61665884
181MP0008789_abnormal_olfactory_epithelium0.61657745
182MP0000955_abnormal_spinal_cord0.61120134
183MP0004264_abnormal_extraembryonic_tissu0.61111449
184MP0000266_abnormal_heart_morphology0.59558442

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.96324022
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.29409126
3Absent/shortened dynein arms (HP:0200106)7.29409126
4Abnormal respiratory epithelium morphology (HP:0012253)6.53571382
5Abnormal respiratory motile cilium morphology (HP:0005938)6.53571382
6Abnormal respiratory motile cilium physiology (HP:0012261)6.49180609
7Rhinitis (HP:0012384)6.36956752
8Abnormal ciliary motility (HP:0012262)5.23437760
9Chronic bronchitis (HP:0004469)5.19794735
10Rhabdomyolysis (HP:0003201)5.11596337
11Fatigue (HP:0012378)4.69361409
12Panhypogammaglobulinemia (HP:0003139)4.23368369
13Nemaline bodies (HP:0003798)4.21732864
14Agammaglobulinemia (HP:0004432)4.08847947
15Thrombocytosis (HP:0001894)4.08722149
16Muscle fiber inclusion bodies (HP:0100299)3.97969959
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.86546184
18Exercise-induced myalgia (HP:0003738)3.74955198
19Bony spicule pigmentary retinopathy (HP:0007737)3.66463397
20Abnormality of the anterior horn cell (HP:0006802)3.59521157
21Degeneration of anterior horn cells (HP:0002398)3.59521157
22Nephronophthisis (HP:0000090)3.52747404
23Nasal polyposis (HP:0100582)3.45061025
24Supernumerary spleens (HP:0009799)3.44763603
25Bronchiectasis (HP:0002110)3.37156251
26Infertility (HP:0000789)3.30586802
27Ventricular tachycardia (HP:0004756)3.24203369
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.20579477
29Atrioventricular block (HP:0001678)3.18508539
30Abnormal pupillary function (HP:0007686)3.08309692
31Poor eye contact (HP:0000817)3.08226605
32Abnormality of the lower motor neuron (HP:0002366)3.00354743
33Rimmed vacuoles (HP:0003805)2.97717296
34Spontaneous abortion (HP:0005268)2.92679392
35Ependymoma (HP:0002888)2.91943764
36Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.91275205
37Short 1st metacarpal (HP:0010034)2.91275205
38Progressive muscle weakness (HP:0003323)2.89031007
39Muscle stiffness (HP:0003552)2.87205658
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.78446403
41Loss of speech (HP:0002371)2.78189653
42Increased intramyocellular lipid droplets (HP:0012240)2.76203625
43Abnormality of the prostate (HP:0008775)2.76160023
44Long nose (HP:0003189)2.75976823
45Septo-optic dysplasia (HP:0100842)2.75027026
46Abnormality of the nasal mucosa (HP:0000433)2.74599533
47Bronchitis (HP:0012387)2.73310121
48Muscle hypertrophy of the lower extremities (HP:0008968)2.70221699
49Chronic obstructive pulmonary disease (HP:0006510)2.67851898
50Obstructive lung disease (HP:0006536)2.67851898
51Myoglobinuria (HP:0002913)2.67672992
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.65268941
53Recurrent bacterial skin infections (HP:0005406)2.65202741
54Recurrent abscess formation (HP:0002722)2.59753475
55Central scotoma (HP:0000603)2.58977459
56Meningitis (HP:0001287)2.58792120
57Abnormality of the renal medulla (HP:0100957)2.58675091
58Ketoacidosis (HP:0001993)2.55445307
59Abnormality of the 1st metacarpal (HP:0010009)2.54306483
60Congenital stationary night blindness (HP:0007642)2.53110234
61Abnormality of midbrain morphology (HP:0002418)2.50104073
62Molar tooth sign on MRI (HP:0002419)2.50104073
63Medial flaring of the eyebrow (HP:0010747)2.49922479
64Inability to walk (HP:0002540)2.49519196
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49016019
66Global brain atrophy (HP:0002283)2.47423763
67Increased cerebral lipofuscin (HP:0011813)2.46457243
68Attenuation of retinal blood vessels (HP:0007843)2.45596124
69Increased muscle lipid content (HP:0009058)2.44037161
70Bradycardia (HP:0001662)2.43919182
71Viral hepatitis (HP:0006562)2.43340843
72Gait imbalance (HP:0002141)2.41203976
73Abnormality of male internal genitalia (HP:0000022)2.37447724
74Amyotrophic lateral sclerosis (HP:0007354)2.37242852
75Type II diabetes mellitus (HP:0005978)2.37081356
76Scotoma (HP:0000575)2.36380640
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34948893
78Areflexia of lower limbs (HP:0002522)2.34871160
79B lymphocytopenia (HP:0010976)2.34460573
80Myopathic facies (HP:0002058)2.33715120
81Decreased central vision (HP:0007663)2.33686334
82Premature ovarian failure (HP:0008209)2.33452579
83Abnormality of the labia minora (HP:0012880)2.33359699
84Asymmetric septal hypertrophy (HP:0001670)2.33073275
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.32425041
86Dyschromatopsia (HP:0007641)2.31528731
87Spinal muscular atrophy (HP:0007269)2.31389516
88Congenital primary aphakia (HP:0007707)2.31095934
89Heart block (HP:0012722)2.30994934
90Encephalitis (HP:0002383)2.30393283
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28409365
92Aplastic anemia (HP:0001915)2.28136487
93Atrophy/Degeneration involving motor neurons (HP:0007373)2.25997596
94Abnormal rod and cone electroretinograms (HP:0008323)2.24078158
95Subaortic stenosis (HP:0001682)2.23816431
96Abnormality of the left ventricular outflow tract (HP:0011103)2.23816431
97Gonadotropin excess (HP:0000837)2.23580452
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22252886
99Dicarboxylic aciduria (HP:0003215)2.22252886
100Recurrent fungal infections (HP:0002841)2.22105424
101Carpal bone hypoplasia (HP:0001498)2.21910707
102Recurrent viral infections (HP:0004429)2.21552055
103Acute hepatic failure (HP:0006554)2.21440768
104Short phalanx of the thumb (HP:0009660)2.19319735
105Vacuolated lymphocytes (HP:0001922)2.18723689
106Facial cleft (HP:0002006)2.18548071
107Myotonia (HP:0002486)2.18519011
108Abnormality of macular pigmentation (HP:0008002)2.17849476
109Wide nose (HP:0000445)2.17662220
110Neoplasm of the oral cavity (HP:0100649)2.17516030
111Acute necrotizing encephalopathy (HP:0006965)2.17454832
11211 pairs of ribs (HP:0000878)2.15354077
113Mitochondrial inheritance (HP:0001427)2.14228071
114Recurrent otitis media (HP:0000403)2.12612883
115True hermaphroditism (HP:0010459)2.12245861
116Missing ribs (HP:0000921)2.11427768
117Exercise intolerance (HP:0003546)2.08607641
118Ketosis (HP:0001946)2.06569082
119Abnormal mitochondria in muscle tissue (HP:0008316)2.05345040
120Nephrogenic diabetes insipidus (HP:0009806)2.04552609
121Pancreatic fibrosis (HP:0100732)2.03164891
122Tubular atrophy (HP:0000092)2.03116584
1233-Methylglutaconic aciduria (HP:0003535)2.03047511
124Abnormal atrioventricular conduction (HP:0005150)2.02542807
125Chronic otitis media (HP:0000389)2.01529149
126Progressive external ophthalmoplegia (HP:0000590)2.01068632
127Cerebral palsy (HP:0100021)2.00293616
128Broad distal phalanx of finger (HP:0009836)2.00043660
129Progressive inability to walk (HP:0002505)1.98430490
130Heterotopia (HP:0002282)1.98187096
131Recurrent cutaneous fungal infections (HP:0011370)1.97711458
132Chronic mucocutaneous candidiasis (HP:0002728)1.97711458
133EMG: myopathic abnormalities (HP:0003458)1.96412746
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96352655
135Mediastinal lymphadenopathy (HP:0100721)1.95978881
136Postaxial foot polydactyly (HP:0001830)1.95043666
137Abnormal protein glycosylation (HP:0012346)1.94440269
138Abnormal glycosylation (HP:0012345)1.94440269
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94440269
140Abnormal protein N-linked glycosylation (HP:0012347)1.94440269
141Exertional dyspnea (HP:0002875)1.93814577
142Acute encephalopathy (HP:0006846)1.92968841
143Optic nerve hypoplasia (HP:0000609)1.92887170
144Tubulointerstitial nephritis (HP:0001970)1.92870618
145Recurrent sinusitis (HP:0011108)1.92591658
146Abnormal social behavior (HP:0012433)1.92322587
147Impaired social interactions (HP:0000735)1.92322587
148Progressive macrocephaly (HP:0004481)1.91665958
149Mutism (HP:0002300)1.90638143
150Chest pain (HP:0100749)1.90491909
151Abnormality of the astrocytes (HP:0100707)1.90386488
152Astrocytoma (HP:0009592)1.90386488
153Abnormality of abdominal situs (HP:0011620)1.90073412
154Abdominal situs inversus (HP:0003363)1.90073412
155Gliosis (HP:0002171)1.89430052
156Hyperammonemia (HP:0001987)1.88880005
157EMG: neuropathic changes (HP:0003445)1.87871546
158Colitis (HP:0002583)1.87741062
159Abnormality of the columella (HP:0009929)1.87652587
160Facial diplegia (HP:0001349)1.87616496
161Granulocytopenia (HP:0001913)1.86206920
162Absent septum pellucidum (HP:0001331)1.85721694
163Bifid tongue (HP:0010297)1.83469164
164Visual hallucinations (HP:0002367)1.83192773
165Congenital hepatic fibrosis (HP:0002612)1.82408111
166Maternal diabetes (HP:0009800)1.79367969
167Type I transferrin isoform profile (HP:0003642)1.79044011
168Lipid accumulation in hepatocytes (HP:0006561)1.78045515
169Pendular nystagmus (HP:0012043)1.74575740
170Aplasia/Hypoplasia of the lens (HP:0008063)1.74325020
171Cystic liver disease (HP:0006706)1.72943834
172Poor coordination (HP:0002370)1.72903054
173Vaginal atresia (HP:0000148)1.72668108
174Male infertility (HP:0003251)1.72353209
175Pancreatic cysts (HP:0001737)1.72342919
176Cone-rod dystrophy (HP:0000548)1.71941658
177Abnormality of the pancreatic islet cells (HP:0006476)1.70946644
178Abnormality of endocrine pancreas physiology (HP:0012093)1.70946644
179Retinitis pigmentosa (HP:0000510)1.70914580
180Hyperinsulinemic hypoglycemia (HP:0000825)1.70502844
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69696681
182Postaxial hand polydactyly (HP:0001162)1.69000779
183Constricted visual fields (HP:0001133)1.68135890
184Genital tract atresia (HP:0001827)1.65215762
185Polydipsia (HP:0001959)1.64250736
186Abnormal drinking behavior (HP:0030082)1.64250736
187Chronic hepatic failure (HP:0100626)1.63919657
188Aplasia/Hypoplasia of the tongue (HP:0010295)1.62886484
189Oculomotor apraxia (HP:0000657)1.62828663
190Renal duplication (HP:0000075)1.60521865
191Intestinal atresia (HP:0011100)1.59633726
192Abnormality of dentin (HP:0010299)1.59182383
193Anencephaly (HP:0002323)1.58764411
194Short ribs (HP:0000773)1.58061124
195Abnormality of ocular smooth pursuit (HP:0000617)1.56906377
196Chronic sinusitis (HP:0011109)1.56873698
197Colon cancer (HP:0003003)1.54715718
198Tubulointerstitial abnormality (HP:0001969)1.53563202
199Aplasia/Hypoplasia of the sternum (HP:0006714)1.53461777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.64078951
2PDK36.64078951
3MAP4K14.45123044
4PDK24.00896386
5PIK3CG2.88791756
6PRKD32.84593967
7TESK12.83467302
8TEC2.53917888
9ICK2.39193761
10TAOK32.38148377
11MAPK152.34929429
12NEK92.30565422
13MAPKAPK52.27534863
14WEE12.27185950
15VRK22.23810193
16PNCK2.22595271
17EIF2AK32.17860758
18NEK22.11439714
19KDR2.07358225
20PKN22.00288255
21NTRK11.99392050
22SIK31.98523371
23KSR11.97618341
24CDC71.96868158
25MAP2K31.91435082
26TESK21.86958625
27RPS6KA51.78490019
28NEK11.75912011
29JAK31.75747751
30TTK1.72991100
31PASK1.71695866
32RPS6KA41.66606880
33CDK121.64834768
34BRSK21.63604007
35BUB11.61517166
36BTK1.60521642
37MUSK1.57127767
38GRK71.52770113
39RIPK41.47375209
40INSRR1.46140438
41CDK191.46104508
42LMTK21.42310376
43MAP3K111.40442026
44NUAK11.39584326
45PHKG21.37203288
46PHKG11.37203288
47BCR1.37028627
48NTRK21.36524089
49DYRK31.33184431
50PLK11.32135844
51SYK1.30935077
52MAP3K131.28189030
53ITK1.28107113
54WNK31.26883827
55TBK11.24526731
56PIM21.22667442
57MKNK11.21355494
58KIT1.20258910
59CHEK21.13431180
60CSF1R1.09980923
61MAP3K61.09686676
62RET1.08022927
63MAP3K141.06632895
64CDK61.02999195
65WNK41.02573819
66MAP2K40.96929400
67NME10.94814036
68MAP3K100.91789881
69NME20.91194379
70MAP3K120.88165355
71CHEK10.86697676
72MAPK40.85919284
73IKBKB0.84989308
74TTN0.82794799
75JAK20.81798773
76ATR0.81396950
77MTOR0.79710584
78STK160.78987278
79PBK0.78819450
80PINK10.78218596
81BRSK10.75759697
82DYRK1B0.75657684
83ACVR1B0.75510458
84MAP3K70.74794692
85TNK20.74268571
86MAP2K70.72426979
87MAP2K20.72118876
88TYK20.71646870
89MARK10.71283637
90PTK2B0.71192616
91LYN0.70399053
92BRD40.69239343
93ZAP700.67997377
94ABL10.67982073
95WNK10.67787793
96UHMK10.67166394
97TXK0.66305669
98MAPK120.65769849
99STK380.62537168
100CCNB10.61245403
101FLT30.60309342
102FES0.60169639
103BLK0.59846583
104MYLK0.59790562
105ARAF0.58876775
106GRK10.58057169
107MINK10.56706421
108TYRO30.56316498
109PRKD20.55875736
110TLK10.55491936
111MATK0.55373867
112ATM0.54536986
113PIM10.53377938
114LCK0.53373378
115AURKA0.52566018
116AURKB0.51538159
117LRRK20.50958533
118STK40.50563879
119RIPK10.50534761
120PAK60.50444277
121MAPK100.49504454
122RPS6KB20.49483979
123CDK10.49448147
124DAPK20.49270518
125MAP3K90.49210352
126CDC42BPA0.48876005
127CDK70.48394538
128STK390.47215076
129MELK0.46952988
130CDK20.46128568
131GRK60.44989544
132CDK90.44826186
133ALK0.44266821
134PRKCQ0.44197288
135MARK30.44174119
136SRPK10.44055393
137OBSCN0.43618759
138STK30.42219360
139HIPK20.41965359
140MAPK30.41814628
141PRKAA10.41484521
142ZAK0.41208011
143MAP2K60.41047385
144MAPK70.40878648
145YES10.38225650
146PRKCI0.37892651
147SCYL20.36875084
148DAPK10.36628913
149MAPKAPK30.36267406
150TAF10.36258968
151PLK30.36184270
152LIMK10.35631770
153EPHA20.34750650
154RPS6KC10.34747944
155RPS6KL10.34747944
156RPS6KA60.34663303
157BCKDK0.34099228
158DYRK20.33983543
159DAPK30.33978856
160CDK180.33166078
161ERBB20.31104712
162PRKDC0.30217696
163EEF2K0.29217030
164MET0.29128922
165RPS6KB10.28435583
166PAK20.28322834
167PAK30.27559598
168CLK10.27222811
169PAK10.26476815
170PDK10.26292484
171PKN10.26110178
172GSK3B0.25983343
173CDK40.24884230
174MAP3K50.24706286
175CSNK1D0.23395718
176CSNK2A20.22819550
177AKT20.22481760
178VRK10.21018534
179MAP3K80.20770358
180CDK140.19879694

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.55474810
2Primary immunodeficiency_Homo sapiens_hsa053403.22664136
3Asthma_Homo sapiens_hsa053103.09626148
4RNA transport_Homo sapiens_hsa030132.78419363
5Mismatch repair_Homo sapiens_hsa034302.70813925
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.61695649
7DNA replication_Homo sapiens_hsa030302.59344289
8mRNA surveillance pathway_Homo sapiens_hsa030152.52171451
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.34382667
10Oocyte meiosis_Homo sapiens_hsa041142.25984549
11Basal transcription factors_Homo sapiens_hsa030222.25399797
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.24014291
13Selenocompound metabolism_Homo sapiens_hsa004502.18774981
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.17389635
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11755262
16Spliceosome_Homo sapiens_hsa030402.10323145
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.09666565
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07072576
19Base excision repair_Homo sapiens_hsa034102.04197646
20Cell cycle_Homo sapiens_hsa041102.04137272
21Butanoate metabolism_Homo sapiens_hsa006501.97932676
22Glucagon signaling pathway_Homo sapiens_hsa049221.92907560
23Type I diabetes mellitus_Homo sapiens_hsa049401.91044802
24Fanconi anemia pathway_Homo sapiens_hsa034601.90763631
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86102906
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.85125075
27Leishmaniasis_Homo sapiens_hsa051401.83780067
28Allograft rejection_Homo sapiens_hsa053301.77218448
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76041650
30Parkinsons disease_Homo sapiens_hsa050121.73488905
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69922903
32Autoimmune thyroid disease_Homo sapiens_hsa053201.68868742
33Pyruvate metabolism_Homo sapiens_hsa006201.68412459
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67438228
35Pentose phosphate pathway_Homo sapiens_hsa000301.66694889
36Fatty acid elongation_Homo sapiens_hsa000621.62670781
37Dorso-ventral axis formation_Homo sapiens_hsa043201.61298374
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58042828
39Nucleotide excision repair_Homo sapiens_hsa034201.53815108
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49147964
41Graft-versus-host disease_Homo sapiens_hsa053321.48785102
42Oxidative phosphorylation_Homo sapiens_hsa001901.43386903
43Ribosome_Homo sapiens_hsa030101.43335878
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42753188
45Cardiac muscle contraction_Homo sapiens_hsa042601.42309664
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42214139
47Vitamin B6 metabolism_Homo sapiens_hsa007501.41162647
48Hedgehog signaling pathway_Homo sapiens_hsa043401.40968143
49B cell receptor signaling pathway_Homo sapiens_hsa046621.39403385
50Peroxisome_Homo sapiens_hsa041461.38528432
51Basal cell carcinoma_Homo sapiens_hsa052171.38164269
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36163872
53N-Glycan biosynthesis_Homo sapiens_hsa005101.35616916
54Homologous recombination_Homo sapiens_hsa034401.31833348
55Purine metabolism_Homo sapiens_hsa002301.30729817
56Propanoate metabolism_Homo sapiens_hsa006401.27914386
57Systemic lupus erythematosus_Homo sapiens_hsa053221.27179313
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23802910
59Biosynthesis of amino acids_Homo sapiens_hsa012301.22725853
60Sulfur relay system_Homo sapiens_hsa041221.17836253
61Carbon metabolism_Homo sapiens_hsa012001.15560987
62Alcoholism_Homo sapiens_hsa050341.15430715
63Tryptophan metabolism_Homo sapiens_hsa003801.13874653
64Acute myeloid leukemia_Homo sapiens_hsa052211.13622139
65Viral myocarditis_Homo sapiens_hsa054161.13486205
66Herpes simplex infection_Homo sapiens_hsa051681.13000813
67RNA degradation_Homo sapiens_hsa030181.12760725
68Pyrimidine metabolism_Homo sapiens_hsa002401.12510988
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12231298
70Prolactin signaling pathway_Homo sapiens_hsa049171.08987561
71Glycosaminoglycan degradation_Homo sapiens_hsa005311.08689842
72Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08407814
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05731634
74Hippo signaling pathway_Homo sapiens_hsa043901.03967292
75Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00690533
76Huntingtons disease_Homo sapiens_hsa050161.00162243
77Insulin secretion_Homo sapiens_hsa049110.99544820
78Shigellosis_Homo sapiens_hsa051310.97982257
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95992026
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95621769
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.95373414
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93655797
83Platelet activation_Homo sapiens_hsa046110.93316930
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.93003051
85Staphylococcus aureus infection_Homo sapiens_hsa051500.92265656
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84620609
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84316134
88Measles_Homo sapiens_hsa051620.82770177
89Rheumatoid arthritis_Homo sapiens_hsa053230.82140216
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81165209
91Non-homologous end-joining_Homo sapiens_hsa034500.80569959
92mTOR signaling pathway_Homo sapiens_hsa041500.78525168
93AMPK signaling pathway_Homo sapiens_hsa041520.77876702
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77507608
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76684139
96Viral carcinogenesis_Homo sapiens_hsa052030.74278957
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73047214
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73029941
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71856064
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71654695
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.70876845
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.70764730
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69585097
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69085480
105Fructose and mannose metabolism_Homo sapiens_hsa000510.68349690
106Alzheimers disease_Homo sapiens_hsa050100.68118104
107p53 signaling pathway_Homo sapiens_hsa041150.67541933
108Type II diabetes mellitus_Homo sapiens_hsa049300.67507549
109Wnt signaling pathway_Homo sapiens_hsa043100.66424164
110Insulin signaling pathway_Homo sapiens_hsa049100.65627527
111One carbon pool by folate_Homo sapiens_hsa006700.65436380
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64458767
113Estrogen signaling pathway_Homo sapiens_hsa049150.63534367
114Toxoplasmosis_Homo sapiens_hsa051450.63358385
115Amphetamine addiction_Homo sapiens_hsa050310.62957401
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62411298
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.61894418
118Regulation of autophagy_Homo sapiens_hsa041400.61834319
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.61805037
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61540315
121Tuberculosis_Homo sapiens_hsa051520.61341202
122Osteoclast differentiation_Homo sapiens_hsa043800.59041015
123Antigen processing and presentation_Homo sapiens_hsa046120.58621823
124Galactose metabolism_Homo sapiens_hsa000520.58447385
125Lysine degradation_Homo sapiens_hsa003100.57365648
126Colorectal cancer_Homo sapiens_hsa052100.57241646
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.55557929
128Hematopoietic cell lineage_Homo sapiens_hsa046400.55408465
129Epstein-Barr virus infection_Homo sapiens_hsa051690.55060947
130Olfactory transduction_Homo sapiens_hsa047400.54735388
131HTLV-I infection_Homo sapiens_hsa051660.54462070
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54078588
133Linoleic acid metabolism_Homo sapiens_hsa005910.53502377
134Phagosome_Homo sapiens_hsa041450.52368579
135Retinol metabolism_Homo sapiens_hsa008300.51722637
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51307181
137Long-term potentiation_Homo sapiens_hsa047200.51155208
138RNA polymerase_Homo sapiens_hsa030200.50991349
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.50011153
140Hepatitis C_Homo sapiens_hsa051600.49881576
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49512014
142Fatty acid biosynthesis_Homo sapiens_hsa000610.48713005
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48158910
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47834249
145Thyroid hormone synthesis_Homo sapiens_hsa049180.47688588
146Tight junction_Homo sapiens_hsa045300.47668566
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47517644
148Protein export_Homo sapiens_hsa030600.46078511
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45197645
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45154565
151Dilated cardiomyopathy_Homo sapiens_hsa054140.45040150
152Proteasome_Homo sapiens_hsa030500.43014452
153Renal cell carcinoma_Homo sapiens_hsa052110.42274413
154Non-small cell lung cancer_Homo sapiens_hsa052230.39989645
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39488140
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39338540
157Insulin resistance_Homo sapiens_hsa049310.38738471
158Renin-angiotensin system_Homo sapiens_hsa046140.38422851
159Metabolic pathways_Homo sapiens_hsa011000.38204742
160Inositol phosphate metabolism_Homo sapiens_hsa005620.38100380
161Notch signaling pathway_Homo sapiens_hsa043300.37451953
162Synaptic vesicle cycle_Homo sapiens_hsa047210.37356276
163Influenza A_Homo sapiens_hsa051640.35822949
164Circadian rhythm_Homo sapiens_hsa047100.34868494
165Dopaminergic synapse_Homo sapiens_hsa047280.33860352
166Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31634555
167TGF-beta signaling pathway_Homo sapiens_hsa043500.26800679
168Melanogenesis_Homo sapiens_hsa049160.26196593
169Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23405188

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