MAOB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.08029349
2L-phenylalanine catabolic process (GO:0006559)7.08029349
3L-phenylalanine metabolic process (GO:0006558)6.70445506
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.70445506
5aromatic amino acid family catabolic process (GO:0009074)5.92872707
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.76823659
7epoxygenase P450 pathway (GO:0019373)5.53595619
8exogenous drug catabolic process (GO:0042738)5.28194714
9high-density lipoprotein particle remodeling (GO:0034375)5.06585428
10alpha-linolenic acid metabolic process (GO:0036109)5.04603079
11bile acid biosynthetic process (GO:0006699)4.97538239
12indole-containing compound catabolic process (GO:0042436)4.92673226
13indolalkylamine catabolic process (GO:0046218)4.92673226
14tryptophan catabolic process (GO:0006569)4.92673226
15glyoxylate metabolic process (GO:0046487)4.84096092
16kynurenine metabolic process (GO:0070189)4.83423676
17tryptophan metabolic process (GO:0006568)4.82765538
18sulfur amino acid catabolic process (GO:0000098)4.78771185
19urea metabolic process (GO:0019627)4.72807659
20urea cycle (GO:0000050)4.72807659
21protein carboxylation (GO:0018214)4.66428475
22peptidyl-glutamic acid carboxylation (GO:0017187)4.66428475
23negative regulation of fibrinolysis (GO:0051918)4.63669865
24regulation of cholesterol esterification (GO:0010872)4.63156629
25tyrosine metabolic process (GO:0006570)4.59773423
26reverse cholesterol transport (GO:0043691)4.58002819
27cysteine metabolic process (GO:0006534)4.55892735
28aromatic amino acid family metabolic process (GO:0009072)4.51652820
29regulation of fibrinolysis (GO:0051917)4.50448036
30bile acid metabolic process (GO:0008206)4.38141024
31protein-lipid complex remodeling (GO:0034368)4.37524740
32macromolecular complex remodeling (GO:0034367)4.37524740
33plasma lipoprotein particle remodeling (GO:0034369)4.37524740
34nitrogen cycle metabolic process (GO:0071941)4.36298806
35complement activation, alternative pathway (GO:0006957)4.34134237
36phospholipid efflux (GO:0033700)4.34129149
37acylglycerol homeostasis (GO:0055090)4.31162138
38triglyceride homeostasis (GO:0070328)4.31162138
39omega-hydroxylase P450 pathway (GO:0097267)4.29756614
40regulation of triglyceride catabolic process (GO:0010896)4.28912400
41regulation of protein activation cascade (GO:2000257)4.27994204
42cellular ketone body metabolic process (GO:0046950)4.20865807
43blood coagulation, intrinsic pathway (GO:0007597)4.19362723
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.15331844
45lysine catabolic process (GO:0006554)4.15056362
46lysine metabolic process (GO:0006553)4.15056362
47serine family amino acid catabolic process (GO:0009071)4.10944787
48indolalkylamine metabolic process (GO:0006586)4.08799986
49homocysteine metabolic process (GO:0050667)4.05111740
50alpha-amino acid catabolic process (GO:1901606)4.04957154
51NADH metabolic process (GO:0006734)4.01053619
52amino-acid betaine metabolic process (GO:0006577)4.00970551
53negative regulation of cholesterol transport (GO:0032375)3.98286468
54negative regulation of sterol transport (GO:0032372)3.98286468
55regulation of complement activation (GO:0030449)3.97738402
56bile acid and bile salt transport (GO:0015721)3.96191368
57response to mercury ion (GO:0046689)3.94439894
58plasma lipoprotein particle clearance (GO:0034381)3.94282175
59cholesterol efflux (GO:0033344)3.90043226
60coenzyme catabolic process (GO:0009109)3.86932598
61ethanol metabolic process (GO:0006067)3.86688805
62cellular amino acid catabolic process (GO:0009063)3.82439890
63glutamate metabolic process (GO:0006536)3.75702192
64low-density lipoprotein particle remodeling (GO:0034374)3.73927171
65plasma lipoprotein particle assembly (GO:0034377)3.70888975
66short-chain fatty acid metabolic process (GO:0046459)3.69151671
67regulation of cholesterol homeostasis (GO:2000188)3.69030215
68cellular modified amino acid catabolic process (GO:0042219)3.65974993
69cellular glucuronidation (GO:0052695)3.64198732
70imidazole-containing compound metabolic process (GO:0052803)3.63150095
71ketone body metabolic process (GO:1902224)3.62478846
72drug catabolic process (GO:0042737)3.62243802
73intestinal cholesterol absorption (GO:0030299)3.57196919
74benzene-containing compound metabolic process (GO:0042537)3.54436648
75phenylpropanoid metabolic process (GO:0009698)3.48336683
76organic acid catabolic process (GO:0016054)3.47404553
77carboxylic acid catabolic process (GO:0046395)3.47404553
78fatty acid beta-oxidation (GO:0006635)3.45934132
79regulation of bile acid biosynthetic process (GO:0070857)3.43784372
80monocarboxylic acid catabolic process (GO:0072329)3.42703445
81positive regulation of lipid catabolic process (GO:0050996)3.41504657
82fatty acid oxidation (GO:0019395)3.40095802
83cellular biogenic amine catabolic process (GO:0042402)3.40088131
84amine catabolic process (GO:0009310)3.40088131
85negative regulation of lipase activity (GO:0060192)3.39004840
86plasma lipoprotein particle organization (GO:0071827)3.37865602
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.37183647
88lipoprotein metabolic process (GO:0042157)3.36712715
89regulation of cholesterol biosynthetic process (GO:0045540)3.36407353
90phospholipid homeostasis (GO:0055091)3.36207722
91lipid oxidation (GO:0034440)3.35441271
92fatty acid catabolic process (GO:0009062)3.33354192
93dicarboxylic acid biosynthetic process (GO:0043650)3.32506309
94ethanol oxidation (GO:0006069)3.31625514
95positive regulation of lipoprotein lipase activity (GO:0051006)3.30568923
96positive regulation of triglyceride lipase activity (GO:0061365)3.30568923
97cholesterol homeostasis (GO:0042632)3.30522647
98aldehyde catabolic process (GO:0046185)3.30017827
99glucuronate metabolic process (GO:0019585)3.29608140
100uronic acid metabolic process (GO:0006063)3.29608140
101alkaloid metabolic process (GO:0009820)3.29535903
102protein activation cascade (GO:0072376)3.27649418
103very-low-density lipoprotein particle assembly (GO:0034379)3.27603460
104protein-lipid complex assembly (GO:0065005)3.26267919
105creatine metabolic process (GO:0006600)3.25375741
106negative regulation of hemostasis (GO:1900047)3.25359976
107negative regulation of blood coagulation (GO:0030195)3.25359976
108drug metabolic process (GO:0017144)3.25316430
109sterol homeostasis (GO:0055092)3.24865508
110fibrinolysis (GO:0042730)3.24808850
111arginine metabolic process (GO:0006525)3.23821213
112aspartate family amino acid catabolic process (GO:0009068)3.23509977
113oxidative demethylation (GO:0070989)3.17892420
114complement activation, classical pathway (GO:0006958)3.12735048
115regulation of plasminogen activation (GO:0010755)3.10334024
116fat-soluble vitamin biosynthetic process (GO:0042362)3.07464315
117fructose metabolic process (GO:0006000)3.06390622
118complement activation (GO:0006956)3.02725897
119oxaloacetate metabolic process (GO:0006107)3.00733508
120negative regulation of protein activation cascade (GO:2000258)2.97610324
121negative regulation of coagulation (GO:0050819)2.94966450
122flavonoid metabolic process (GO:0009812)2.90858955
123hormone catabolic process (GO:0042447)2.89771662
124regulation of lipoprotein metabolic process (GO:0050746)2.89674205
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87001299
126negative regulation of wound healing (GO:0061045)2.86358946
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.84146974
128acute-phase response (GO:0006953)2.77849421
129phosphate ion transmembrane transport (GO:0035435)2.77117089
130triglyceride catabolic process (GO:0019433)2.72796402
131neutral lipid catabolic process (GO:0046461)2.72639857
132acylglycerol catabolic process (GO:0046464)2.72639857
133primary alcohol catabolic process (GO:0034310)2.66730376
134negative regulation of complement activation (GO:0045916)2.66211145
135regulation of cholesterol metabolic process (GO:0090181)2.65700410
136positive regulation of blood coagulation (GO:0030194)2.64890828
137positive regulation of hemostasis (GO:1900048)2.64890828
138regulation of humoral immune response (GO:0002920)2.64593311
139regulation of apoptotic cell clearance (GO:2000425)2.63869779
140regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61429875
141carnitine metabolic process (GO:0009437)2.60990014
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55905353
143regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.51375022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.38032020
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27455365
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.88683114
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.62515209
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.93332057
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35371161
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.33401939
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.68806325
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.25677089
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79317130
11EZH2_22144423_ChIP-Seq_EOC_Human2.20436451
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13812268
13GATA1_22025678_ChIP-Seq_K562_Human2.02567155
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1396905
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99087941
16CLOCK_20551151_ChIP-Seq_293T_Human1.79562274
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.78071289
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75463057
19DROSHA_22980978_ChIP-Seq_HELA_Human1.75125532
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62342951
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.61572513
22HTT_18923047_ChIP-ChIP_STHdh_Human1.57081847
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56085161
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55105285
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49599169
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33802442
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.30634362
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29922151
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29858609
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29858609
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.25679485
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.25476948
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25183476
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24556689
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20655157
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.19213388
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15169396
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14319040
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13933828
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13723632
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10467291
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.09647719
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09561704
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.07021950
45GBX2_23144817_ChIP-Seq_PC3_Human1.06710072
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06691223
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05721598
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98186146
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96910265
50WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95575073
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95136953
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95099023
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93916841
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93835327
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92766688
56REST_21632747_ChIP-Seq_MESCs_Mouse0.91566401
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91382662
58RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91202593
59CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90480288
60RNF2_27304074_Chip-Seq_ESCs_Mouse0.90418027
61NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90119228
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90119228
63EED_16625203_ChIP-ChIP_MESCs_Mouse0.89115499
64JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88706021
65GATA4_25053715_ChIP-Seq_YYC3_Human0.87511783
66NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85973452
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85734868
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.85508356
69ESR1_21235772_ChIP-Seq_MCF-7_Human0.84283149
70BCAT_22108803_ChIP-Seq_LS180_Human0.84119304
71FOXA1_25552417_ChIP-Seq_VCAP_Human0.84095335
72REST_18959480_ChIP-ChIP_MESCs_Mouse0.83447634
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83379472
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83234730
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81641979
76PIAS1_25552417_ChIP-Seq_VCAP_Human0.81125939
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80974811
78EZH2_27304074_Chip-Seq_ESCs_Mouse0.80962457
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78841082
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78104029
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73919487
82SMC4_20622854_ChIP-Seq_HELA_Human0.73526394
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73308579
84AR_20517297_ChIP-Seq_VCAP_Human0.71633319
85ZFP281_18757296_ChIP-ChIP_E14_Mouse0.71336157
86KDM2B_26808549_Chip-Seq_K562_Human0.71101098
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70913622
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70184663
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70024009
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.69644766
91GATA1_19941826_ChIP-Seq_K562_Human0.68760694
92MYC_27129775_Chip-Seq_CORNEA_Mouse0.67233005
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66933685
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66420509
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.66292562
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.65919453
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.65431254
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.64705848
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.64562743
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.64414235
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.64061857
102FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63731238
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.63352478
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.62963268
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.62525665
106* SOX2_20726797_ChIP-Seq_SW620_Human0.61983301
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61553795
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60800183
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60559660
110ERG_20517297_ChIP-Seq_VCAP_Human0.60440367
111CBP_21632823_ChIP-Seq_H3396_Human0.60283753
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59345378
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.59112209
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59029047
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58525821
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.58000636
117* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.57253343
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56569557
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55534995
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55409793
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.55228562
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.54512591
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.54157779
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.53460925
125CDX2_22108803_ChIP-Seq_LS180_Human0.53079073
126P53_21459846_ChIP-Seq_SAOS-2_Human0.52885746
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.51888788
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51623892
129ETV2_25802403_ChIP-Seq_MESCs_Mouse0.51553866
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.49558274
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49503920
132LXR_22292898_ChIP-Seq_THP-1_Human0.49176472
133* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48954598
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.48390676
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.48390676
136MYC_19915707_ChIP-ChIP_AK7_Human0.47937380
137REST_19997604_ChIP-ChIP_NEURONS_Mouse0.47804986
138TP63_23658742_ChIP-Seq_EP156T_Human0.47368008
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.46611332
140GATA2_19941826_ChIP-Seq_K562_Human0.46406300
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.46289049
142* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46238546
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.46083011
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.45264978
145STAT1_17558387_ChIP-Seq_HELA_Human0.45233154
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.44910482
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.43716434
148CTCF_27219007_Chip-Seq_Bcells_Human0.43673886
149NCOR_22424771_ChIP-Seq_293T_Human0.43292416
150CEBPB_22108803_ChIP-Seq_LS180_Human0.43256125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.58527301
2MP0005360_urolithiasis6.52403064
3MP0005085_abnormal_gallbladder_physiolo5.80816891
4MP0005365_abnormal_bile_salt5.76453854
5MP0008875_abnormal_xenobiotic_pharmacok4.62915488
6MP0003806_abnormal_nucleotide_metabolis3.82300996
7MP0003252_abnormal_bile_duct3.61272645
8MP0003195_calcinosis3.46730598
9MP0010329_abnormal_lipoprotein_level3.33974345
10MP0009840_abnormal_foam_cell3.14529223
11MP0005083_abnormal_biliary_tract2.88147953
12MP0005332_abnormal_amino_acid2.64054414
13MP0001666_abnormal_nutrient_absorption2.56212602
14MP0000751_myopathy2.52678209
15MP0002118_abnormal_lipid_homeostasis2.18160107
16MP0003879_abnormal_hair_cell2.03971412
17MP0000609_abnormal_liver_physiology1.97043666
18MP0004270_analgesia1.94829869
19MP0004215_abnormal_myocardial_fiber1.90651171
20MP0002138_abnormal_hepatobiliary_system1.90131917
21MP0004019_abnormal_vitamin_homeostasis1.89810624
22MP0003868_abnormal_feces_composition1.88977620
23MP0004036_abnormal_muscle_relaxation1.82257908
24MP0003191_abnormal_cellular_cholesterol1.81340181
25MP0002837_dystrophic_cardiac_calcinosis1.78911038
26MP0004084_abnormal_cardiac_muscle1.75263955
27MP0005167_abnormal_blood-brain_barrier1.60651695
28MP0005319_abnormal_enzyme/_coenzyme1.56827639
29MP0009780_abnormal_chondrocyte_physiolo1.53289387
30MP0004043_abnormal_pH_regulation1.53228951
31MP0002078_abnormal_glucose_homeostasis1.52073520
32* MP0009643_abnormal_urine_homeostasis1.49592846
33MP0001764_abnormal_homeostasis1.44854844
34MP0000749_muscle_degeneration1.44455520
35MP0005330_cardiomyopathy1.43527323
36MP0005220_abnormal_exocrine_pancreas1.38339819
37MP0009697_abnormal_copulation1.37982289
38MP0004859_abnormal_synaptic_plasticity1.37762809
39MP0006138_congestive_heart_failure1.36533261
40MP0005584_abnormal_enzyme/coenzyme_acti1.36242798
41MP0001944_abnormal_pancreas_morphology1.34655490
42MP0002822_catalepsy1.33728777
43MP0001501_abnormal_sleep_pattern1.33358565
44MP0003646_muscle_fatigue1.33312755
45MP0002909_abnormal_adrenal_gland1.30371787
46MP0002693_abnormal_pancreas_physiology1.30296207
47MP0005379_endocrine/exocrine_gland_phen1.28597934
48MP0002064_seizures1.23769576
49MP0004145_abnormal_muscle_electrophysio1.22681336
50MP0005535_abnormal_body_temperature1.21313124
51MP0002972_abnormal_cardiac_muscle1.19628111
52MP0004087_abnormal_muscle_fiber1.15355359
53MP0005620_abnormal_muscle_contractility1.14853910
54MP0000747_muscle_weakness1.14156691
55MP0005646_abnormal_pituitary_gland1.12607253
56MP0005636_abnormal_mineral_homeostasis1.11179136
57MP0002332_abnormal_exercise_endurance1.10860529
58MP0000920_abnormal_myelination1.09480270
59MP0003283_abnormal_digestive_organ1.08897760
60MP0002877_abnormal_melanocyte_morpholog1.08543179
61MP0003186_abnormal_redox_activity1.06215151
62MP0000013_abnormal_adipose_tissue1.03483857
63MP0009745_abnormal_behavioral_response1.03114631
64MP0000604_amyloidosis1.02375956
65MP0005670_abnormal_white_adipose1.01652748
66MP0003635_abnormal_synaptic_transmissio1.00516099
67MP0010386_abnormal_urinary_bladder1.00303696
68MP0004510_myositis1.00283285
69MP0002876_abnormal_thyroid_physiology0.99916745
70MP0005408_hypopigmentation0.99253154
71MP0004484_altered_response_of0.98916680
72MP0002269_muscular_atrophy0.98473868
73MP0003329_amyloid_beta_deposits0.97510530
74MP0005409_darkened_coat_color0.96646874
75MP0003075_altered_response_to0.95197320
76MP0009642_abnormal_blood_homeostasis0.95066502
77MP0001756_abnormal_urination0.94980614
78MP0005451_abnormal_body_composition0.94676111
79MP0002272_abnormal_nervous_system0.94595224
80MP0003953_abnormal_hormone_level0.94407167
81MP0006036_abnormal_mitochondrial_physio0.93880053
82MP0000598_abnormal_liver_morphology0.93100271
83MP0003633_abnormal_nervous_system0.91338355
84MP0003656_abnormal_erythrocyte_physiolo0.90993582
85MP0002254_reproductive_system_inflammat0.90984858
86MP0005385_cardiovascular_system_phenoty0.90957398
87MP0001544_abnormal_cardiovascular_syste0.90957398
88MP0002971_abnormal_brown_adipose0.89622285
89MP0001486_abnormal_startle_reflex0.89249879
90MP0005448_abnormal_energy_balance0.88677899
91MP0003137_abnormal_impulse_conducting0.88243077
92MP0005334_abnormal_fat_pad0.87917079
93MP0003011_delayed_dark_adaptation0.87419247
94MP0005166_decreased_susceptibility_to0.87402018
95MP0002063_abnormal_learning/memory/cond0.86246547
96MP0004130_abnormal_muscle_cell0.85742898
97MP0000639_abnormal_adrenal_gland0.85279619
98MP0008775_abnormal_heart_ventricle0.85060337
99MP0009115_abnormal_fat_cell0.84787494
100MP0005423_abnormal_somatic_nervous0.84619487
101MP0008569_lethality_at_weaning0.84581447
102MP0002106_abnormal_muscle_physiology0.83626387
103MP0005084_abnormal_gallbladder_morpholo0.81182053
104MP0005647_abnormal_sex_gland0.80822054
105MP0001440_abnormal_grooming_behavior0.78886238
106MP0001661_extended_life_span0.77809016
107MP0002928_abnormal_bile_duct0.75934680
108MP0004264_abnormal_extraembryonic_tissu0.73969887
109MP0003631_nervous_system_phenotype0.73592768
110MP0005165_increased_susceptibility_to0.73114846
111MP0004085_abnormal_heartbeat0.72947717
112MP0000249_abnormal_blood_vessel0.72024905
113MP0002572_abnormal_emotion/affect_behav0.71610886
114MP0005369_muscle_phenotype0.71290523
115MP0009763_increased_sensitivity_to0.70342390
116MP0005376_homeostasis/metabolism_phenot0.68659316
117MP0000759_abnormal_skeletal_muscle0.68333902
118MP0010630_abnormal_cardiac_muscle0.68184594
119MP0001502_abnormal_circadian_rhythm0.67792770
120MP0010368_abnormal_lymphatic_system0.67358640
121MP0000230_abnormal_systemic_arterial0.67182867
122MP0001984_abnormal_olfaction0.66584244
123MP0000538_abnormal_urinary_bladder0.64118067
124MP0003183_abnormal_peptide_metabolism0.63971372
125MP0003690_abnormal_glial_cell0.63967562
126MP0005266_abnormal_metabolism0.62510258
127MP0009764_decreased_sensitivity_to0.61311497
128MP0008469_abnormal_protein_level0.59746508
129MP0001765_abnormal_ion_homeostasis0.59672073
130MP0005058_abnormal_lysosome_morphology0.58339597
131MP0005666_abnormal_adipose_tissue0.56120896
132MP0009765_abnormal_xenobiotic_induced0.54570586
133MP0002638_abnormal_pupillary_reflex0.54352558
134MP0004782_abnormal_surfactant_physiolog0.53436503
135MP0003705_abnormal_hypodermis_morpholog0.49895266
136MP0003959_abnormal_lean_body0.49279246
137MP0000678_abnormal_parathyroid_gland0.46889152
138MP0000003_abnormal_adipose_tissue0.46111631
139MP0003638_abnormal_response/metabolism_0.45791446
140MP0009672_abnormal_birth_weight0.45702817
141MP0000462_abnormal_digestive_system0.45214286
142MP0002970_abnormal_white_adipose0.44598550
143MP0002090_abnormal_vision0.43628513
144MP0005375_adipose_tissue_phenotype0.42942549
145MP0000579_abnormal_nail_morphology0.42913501
146MP0008961_abnormal_basal_metabolism0.41609075
147MP0005187_abnormal_penis_morphology0.39584900
148MP0002168_other_aberrant_phenotype0.39531547
149MP0002136_abnormal_kidney_physiology0.36525686
150MP0006276_abnormal_autonomic_nervous0.36275734
151MP0003300_gastrointestinal_ulcer0.34903582
152MP0005248_abnormal_Harderian_gland0.34657924

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36891624
2Intrahepatic cholestasis (HP:0001406)6.24152848
3Hypoglycemic coma (HP:0001325)5.98166824
4Deep venous thrombosis (HP:0002625)5.92779049
5Xanthomatosis (HP:0000991)5.62910958
6Prolonged partial thromboplastin time (HP:0003645)5.61703456
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.57139107
8Hypobetalipoproteinemia (HP:0003563)5.33464398
9Hypoglycemic seizures (HP:0002173)4.97531843
10Hyperinsulinemic hypoglycemia (HP:0000825)4.74617860
11Ketosis (HP:0001946)4.65404729
12Hyperlipoproteinemia (HP:0010980)4.65361945
13Ketoacidosis (HP:0001993)4.36872000
14Abnormality of the common coagulation pathway (HP:0010990)4.15193184
15Complement deficiency (HP:0004431)4.13786432
16Hypolipoproteinemia (HP:0010981)4.10766157
17Hyperammonemia (HP:0001987)4.02920717
18Abnormality of the intrinsic pathway (HP:0010989)4.01006433
19Epidermoid cyst (HP:0200040)3.94115218
20Conjugated hyperbilirubinemia (HP:0002908)3.92314306
21Hyperglycinemia (HP:0002154)3.89627803
22Symptomatic seizures (HP:0011145)3.87107557
23Joint hemorrhage (HP:0005261)3.83944105
24Hyperglycinuria (HP:0003108)3.81929516
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.71189121
26Hypoalphalipoproteinemia (HP:0003233)3.63843387
27Abnormality of glycine metabolism (HP:0010895)3.62522207
28Abnormality of serine family amino acid metabolism (HP:0010894)3.62522207
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.59667922
30Fat malabsorption (HP:0002630)3.59501200
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49592374
32Exercise-induced myalgia (HP:0003738)3.45127386
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.45100404
34Abnormality of methionine metabolism (HP:0010901)3.39296830
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.31665692
36Late onset (HP:0003584)3.28091765
37Abnormality of fatty-acid metabolism (HP:0004359)3.27068329
38Muscle fiber splitting (HP:0003555)3.26370783
39Hyperglycemia (HP:0003074)3.24432781
40Generalized aminoaciduria (HP:0002909)3.20652391
41Bundle branch block (HP:0011710)3.15321059
42Hyporeflexia of lower limbs (HP:0002600)3.14754927
43Hyperbilirubinemia (HP:0002904)3.11241966
44Sudden death (HP:0001699)3.09759270
45Atrioventricular block (HP:0001678)2.99168131
46Hypercholesterolemia (HP:0003124)2.97107994
47Skin nodule (HP:0200036)2.95371014
48Gout (HP:0001997)2.92839203
49Heart block (HP:0012722)2.92260325
50Nephritis (HP:0000123)2.92233917
51Abnormality of purine metabolism (HP:0004352)2.91971608
52Abnormality of complement system (HP:0005339)2.88400374
53Abnormality of nucleobase metabolism (HP:0010932)2.83284697
54Dicarboxylic aciduria (HP:0003215)2.80840399
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80840399
56Abnormal atrioventricular conduction (HP:0005150)2.78595753
57Delayed CNS myelination (HP:0002188)2.73139671
58Metabolic acidosis (HP:0001942)2.69997149
59Abnormality of pyrimidine metabolism (HP:0004353)2.65910874
60Abnormality of endocrine pancreas physiology (HP:0012093)2.65513559
61Abnormality of the pancreatic islet cells (HP:0006476)2.65513559
62Muscle fiber inclusion bodies (HP:0100299)2.64414481
63Hemorrhage of the eye (HP:0011885)2.62193343
64Irritability (HP:0000737)2.56067404
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.51418844
66Abnormality of serum amino acid levels (HP:0003112)2.50147474
67Nemaline bodies (HP:0003798)2.49827440
68Abnormal gallbladder morphology (HP:0012437)2.46939340
69Lethargy (HP:0001254)2.46239836
70Steatorrhea (HP:0002570)2.44341376
71Pancreatic islet-cell hyperplasia (HP:0004510)2.42123836
72Type 1 muscle fiber predominance (HP:0003803)2.41221356
73EMG: myopathic abnormalities (HP:0003458)2.40788334
74Rhabdomyolysis (HP:0003201)2.38163471
75Hepatocellular carcinoma (HP:0001402)2.37254831
76Asymmetric septal hypertrophy (HP:0001670)2.35937565
77Exercise-induced muscle cramps (HP:0003710)2.30781645
78Cerebral edema (HP:0002181)2.30143311
79Enlarged kidneys (HP:0000105)2.29364253
80Ventricular tachycardia (HP:0004756)2.23616799
81Mitral stenosis (HP:0001718)2.23421190
82Brushfield spots (HP:0001088)2.23205977
83Spontaneous abortion (HP:0005268)2.21912002
84Syncope (HP:0001279)2.21891639
85Increased variability in muscle fiber diameter (HP:0003557)2.18420965
86Rickets (HP:0002748)2.16865101
87Glycosuria (HP:0003076)2.16714272
88Abnormality of urine glucose concentration (HP:0011016)2.16714272
89Myocardial infarction (HP:0001658)2.16310160
90Pancreatitis (HP:0001733)2.14621729
91Acanthocytosis (HP:0001927)2.12521253
92Action tremor (HP:0002345)2.12319863
93Sensorimotor neuropathy (HP:0007141)2.11520993
94Myokymia (HP:0002411)2.11099272
95Cholelithiasis (HP:0001081)2.10769207
96Purpura (HP:0000979)2.10420650
97Acute hepatic failure (HP:0006554)2.09954144
98Ventricular arrhythmia (HP:0004308)2.06864288
99Hypochromic microcytic anemia (HP:0004840)2.04837638
100Abnormality of skeletal muscle fiber size (HP:0012084)2.03913263
101Distal lower limb muscle weakness (HP:0009053)2.03460255
102Insulin-resistant diabetes mellitus (HP:0000831)2.02413799
103Potter facies (HP:0002009)2.01264354
104Facial shape deformation (HP:0011334)2.01264354
105Atrial fibrillation (HP:0005110)2.01224255
106Vomiting (HP:0002013)2.00358763
107Abnormality of the calf musculature (HP:0001430)2.00239381
108Myoglobinuria (HP:0002913)1.99652865
109Glomerulonephritis (HP:0000099)1.98085052
110Recurrent gram-negative bacterial infections (HP:0005420)1.97856545
111Alkalosis (HP:0001948)1.95625198
112Vascular calcification (HP:0004934)1.95612421
113Limb hypertonia (HP:0002509)1.95524336
114Malnutrition (HP:0004395)1.95474479
115Insulin resistance (HP:0000855)1.95421305
116Hydroxyprolinuria (HP:0003080)1.94515010
117Abnormality of proline metabolism (HP:0010907)1.94515010
118Amyloidosis (HP:0011034)1.94027555
119Renal cortical cysts (HP:0000803)1.93604326
120Systemic lupus erythematosus (HP:0002725)1.93169356
121Cholecystitis (HP:0001082)1.92484299
122Abnormal gallbladder physiology (HP:0012438)1.92484299
123Neonatal onset (HP:0003623)1.91880704
124Muscle hypertrophy of the lower extremities (HP:0008968)1.91689048
125Abnormality of the gallbladder (HP:0005264)1.91279006
126Right ventricular cardiomyopathy (HP:0011663)1.91263140
127Cardiovascular calcification (HP:0011915)1.90916385
128Menorrhagia (HP:0000132)1.89981199
129Difficulty running (HP:0009046)1.87225464
130Abnormal enzyme/coenzyme activity (HP:0012379)1.87106342
131Increased connective tissue (HP:0009025)1.86934853
132Neck muscle weakness (HP:0000467)1.85969123
133Dilated cardiomyopathy (HP:0001644)1.84346200
134Primary atrial arrhythmia (HP:0001692)1.83820094
135Foot dorsiflexor weakness (HP:0009027)1.83794416
136Abnormality of the foot musculature (HP:0001436)1.80472993
137Neurofibrillary tangles (HP:0002185)1.77593580
138Neonatal hypoglycemia (HP:0001998)1.77558388
139Calf muscle hypertrophy (HP:0008981)1.77510316
140Increased purine levels (HP:0004368)1.77160666
141Hyperuricemia (HP:0002149)1.77160666
142Abnormality of vitamin metabolism (HP:0100508)1.76577555
143Elevated alkaline phosphatase (HP:0003155)1.75900459
144Osteomalacia (HP:0002749)1.75546730
145Proximal tubulopathy (HP:0000114)1.75488066
146Retinal atrophy (HP:0001105)1.75224395
147Ventricular fibrillation (HP:0001663)1.74330157
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.73291399
149Abnormality of the Achilles tendon (HP:0005109)1.73022774
150Supraventricular tachycardia (HP:0004755)1.72438062
151Back pain (HP:0003418)1.70677503
152Pigmentary retinal degeneration (HP:0001146)1.70463055
153Lipoatrophy (HP:0100578)1.69853555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.44472114
2BCKDK5.32133681
3ERN13.84581221
4SIK13.67565178
5MAPK153.64875596
6OBSCN3.24930002
7TAOK33.06636940
8FGFR43.02610533
9MYLK2.58268384
10FLT32.49387641
11TTN2.43524153
12PASK2.38259649
13FRK2.27477131
14MARK12.17818042
15NTRK12.00421014
16MAP3K21.89298488
17TRIB31.68308309
18MAPK121.61517310
19ERBB41.59877305
20DMPK1.56150681
21PIK3CG1.53767121
22UHMK11.48986168
23MAP2K41.47659352
24HIPK21.47440190
25MST1R1.39662951
26PTK61.33733600
27PRKD31.33187540
28MET1.33057670
29CAMK2B1.31677440
30PRPF4B1.29896130
31EPHA31.28614097
32PAK61.28411631
33LATS21.25628277
34MAPKAPK31.15978219
35PINK11.15912386
36DAPK21.13749924
37PTK21.09642382
38PIK3CA1.03903497
39MAPK110.99691105
40MAP3K10.99328787
41JAK20.98183784
42ROCK10.97714535
43WNK40.97057940
44IRAK30.96881719
45PKN20.95821359
46CAMK10.95252875
47MAP3K30.93661679
48DYRK1B0.93637666
49PAK30.92300499
50PRKAA20.92169747
51NTRK20.90557218
52WNK30.90260827
53ROCK20.90230032
54ICK0.88183885
55CAMK2A0.87353116
56PDGFRA0.86071232
57CDK50.82926582
58PRKACG0.81956068
59PRKG10.80134398
60IRAK10.80015431
61TESK10.79749838
62PKN10.79655981
63MAP2K20.79210405
64CASK0.78100526
65LATS10.77914283
66PRKAA10.77141003
67MAP3K60.75151952
68NEK60.73758010
69SGK10.72992702
70MAP2K10.72504093
71MUSK0.70717070
72FGFR20.69651472
73MAP2K60.69420089
74JAK10.69226937
75STK380.68804672
76DAPK30.68476858
77PDK10.67894361
78CAMK2G0.67201452
79RPS6KA30.65151990
80TRPM70.64731522
81PRKCH0.64290369
82EPHB10.63660220
83DDR20.62149984
84SGK4940.61642773
85SGK2230.61642773
86SGK30.61325901
87TYRO30.60210373
88PDK20.59616020
89ERBB20.59554394
90RET0.59247840
91CAMK40.58825912
92GSK3A0.58781107
93STK38L0.58358514
94MAPK70.57840768
95MARK20.57809185
96MAPK100.57456032
97MINK10.57171826
98ABL20.56401926
99MAP3K70.55203384
100TYK20.54546582
101GRK70.54471139
102PRKCZ0.54095660
103PRKCE0.54077004
104SGK20.54012590
105IGF1R0.52755433
106EEF2K0.51175168
107RIPK10.50736943
108LIMK10.50478142
109PRKCG0.50393417
110MAP3K90.49715033
111LMTK20.48868924
112CDC42BPA0.48465611
113CAMK1D0.48305285
114FER0.47087288
115PDPK10.46070175
116FGFR30.45563106
117CAMKK20.43888685
118NTRK30.42361497
119PRKACA0.41381492
120ARAF0.41064900
121TIE10.40737890
122CSNK1G20.40460345
123CSNK1G10.38741238
124KSR20.37650828
125MAPK40.37002479
126PRKCQ0.36588693
127PDK30.36349690
128PDK40.36349690
129NEK90.36178095
130EPHA40.35467691
131PRKD10.35151533
132PRKCA0.34998770
133AKT30.34754351
134IRAK20.34750157
135GRK50.34689919
136PHKG20.33376609
137PHKG10.33376609
138GRK10.33355553
139CAMK1G0.32830085
140CAMK2D0.32500012
141NLK0.32258692
142ITK0.31892301
143PRKG20.31841895
144CAMKK10.29669401
145CSK0.29657668

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83822180
2Nitrogen metabolism_Homo sapiens_hsa009103.57320567
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.19162366
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00506445
5* Tryptophan metabolism_Homo sapiens_hsa003802.80252841
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69440030
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62390077
8Fatty acid degradation_Homo sapiens_hsa000712.62204606
9Arginine biosynthesis_Homo sapiens_hsa002202.61773331
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54940094
11Butanoate metabolism_Homo sapiens_hsa006502.40482739
12Sulfur metabolism_Homo sapiens_hsa009202.37313573
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34231088
14Complement and coagulation cascades_Homo sapiens_hsa046102.26899024
15* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06264803
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05463572
17Propanoate metabolism_Homo sapiens_hsa006402.02894274
18* Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98422074
19Peroxisome_Homo sapiens_hsa041461.97737184
20Fatty acid metabolism_Homo sapiens_hsa012121.96281473
21* Histidine metabolism_Homo sapiens_hsa003401.83030266
22Selenocompound metabolism_Homo sapiens_hsa004501.73852998
23PPAR signaling pathway_Homo sapiens_hsa033201.73545792
24Chemical carcinogenesis_Homo sapiens_hsa052041.69681970
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68801988
26beta-Alanine metabolism_Homo sapiens_hsa004101.61889353
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.61427515
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60341279
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57554271
30Fatty acid elongation_Homo sapiens_hsa000621.56680249
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.53314471
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53149146
33Bile secretion_Homo sapiens_hsa049761.48036644
34Starch and sucrose metabolism_Homo sapiens_hsa005001.45450017
35Folate biosynthesis_Homo sapiens_hsa007901.43941042
36* Tyrosine metabolism_Homo sapiens_hsa003501.42074626
37Caffeine metabolism_Homo sapiens_hsa002321.40315435
38* Phenylalanine metabolism_Homo sapiens_hsa003601.40028433
39Retinol metabolism_Homo sapiens_hsa008301.39143345
40Pyruvate metabolism_Homo sapiens_hsa006201.33821574
41ABC transporters_Homo sapiens_hsa020101.28011041
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27170924
43Fat digestion and absorption_Homo sapiens_hsa049751.26143122
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24765372
45Staphylococcus aureus infection_Homo sapiens_hsa051501.23270548
46Carbon metabolism_Homo sapiens_hsa012001.04123834
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02776826
48Steroid biosynthesis_Homo sapiens_hsa001001.02645107
49Protein export_Homo sapiens_hsa030601.00263099
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.95259330
51Biosynthesis of amino acids_Homo sapiens_hsa012300.93650387
52Arachidonic acid metabolism_Homo sapiens_hsa005900.90775728
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86261527
54* Arginine and proline metabolism_Homo sapiens_hsa003300.85075634
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79388842
56Lysine degradation_Homo sapiens_hsa003100.77154079
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76371470
58Vitamin digestion and absorption_Homo sapiens_hsa049770.75801220
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75478119
60Dilated cardiomyopathy_Homo sapiens_hsa054140.73473849
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71200555
62Glycerolipid metabolism_Homo sapiens_hsa005610.71056691
63Renin secretion_Homo sapiens_hsa049240.68635363
64Sulfur relay system_Homo sapiens_hsa041220.62024791
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61372191
66Vitamin B6 metabolism_Homo sapiens_hsa007500.59978386
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59701817
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59514321
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59448023
70Fatty acid biosynthesis_Homo sapiens_hsa000610.58673079
71Galactose metabolism_Homo sapiens_hsa000520.57474567
72GABAergic synapse_Homo sapiens_hsa047270.55739693
73Mineral absorption_Homo sapiens_hsa049780.51498603
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50450822
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50180305
76Glutathione metabolism_Homo sapiens_hsa004800.50149203
77Insulin secretion_Homo sapiens_hsa049110.50114260
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.50108515
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48856297
80* Metabolic pathways_Homo sapiens_hsa011000.48387601
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.48055213
82Long-term potentiation_Homo sapiens_hsa047200.45811301
83Circadian entrainment_Homo sapiens_hsa047130.45704345
84Insulin resistance_Homo sapiens_hsa049310.44979179
85Gastric acid secretion_Homo sapiens_hsa049710.44655991
86Prion diseases_Homo sapiens_hsa050200.43583545
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43069133
88* Amphetamine addiction_Homo sapiens_hsa050310.42607723
89Cardiac muscle contraction_Homo sapiens_hsa042600.42108554
90Glucagon signaling pathway_Homo sapiens_hsa049220.41638654
91Pentose phosphate pathway_Homo sapiens_hsa000300.41301680
92Linoleic acid metabolism_Homo sapiens_hsa005910.41220638
93Glutamatergic synapse_Homo sapiens_hsa047240.41037312
94Nicotine addiction_Homo sapiens_hsa050330.38711153
95Fructose and mannose metabolism_Homo sapiens_hsa000510.36546549
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35615116
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34989897
98Type II diabetes mellitus_Homo sapiens_hsa049300.33935378
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33792193
100* Serotonergic synapse_Homo sapiens_hsa047260.31168357
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.30539353
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29700817
103Morphine addiction_Homo sapiens_hsa050320.29437765
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29349252
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.27460473
106One carbon pool by folate_Homo sapiens_hsa006700.27269549
107Regulation of autophagy_Homo sapiens_hsa041400.22657403
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20685234
109Thyroid hormone synthesis_Homo sapiens_hsa049180.16925817
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12511133
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.11807525
112AMPK signaling pathway_Homo sapiens_hsa041520.11435485
113Circadian rhythm_Homo sapiens_hsa047100.10730683
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10544948
115Ovarian steroidogenesis_Homo sapiens_hsa049130.09091471
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07498903
117Insulin signaling pathway_Homo sapiens_hsa049100.06157569
118Lysosome_Homo sapiens_hsa041420.05107084
119Vibrio cholerae infection_Homo sapiens_hsa051100.02509230
120* Cocaine addiction_Homo sapiens_hsa050300.01317659
121Renin-angiotensin system_Homo sapiens_hsa046140.00131928
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0486728
123Pancreatic secretion_Homo sapiens_hsa04972-0.0305996
124N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0283127

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