MANSC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein polyglutamylation (GO:0018095)8.51042910
2pathway-restricted SMAD protein phosphorylation (GO:0060389)8.49990739
3endocardial cushion morphogenesis (GO:0003203)8.23009574
4mitochondrion transport along microtubule (GO:0047497)7.27907512
5establishment of mitochondrion localization, microtubule-mediated (GO:0034643)7.27907512
6Notch signaling involved in heart development (GO:0061314)7.02106120
7receptor guanylyl cyclase signaling pathway (GO:0007168)6.97292588
8positive regulation of Notch signaling pathway (GO:0045747)6.89440361
9inner ear receptor cell differentiation (GO:0060113)6.76873701
10transcription from mitochondrial promoter (GO:0006390)6.64539630
11positive regulation of protein homooligomerization (GO:0032464)6.47319862
12negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.30999621
13establishment of mitochondrion localization (GO:0051654)6.19578267
14mesenchyme morphogenesis (GO:0072132)6.07392737
15glycoprotein catabolic process (GO:0006516)5.96470802
16hair cell differentiation (GO:0035315)5.87167695
17peptidyl-histidine modification (GO:0018202)5.79554983
18tRNA methylation (GO:0030488)5.79422105
19mechanoreceptor differentiation (GO:0042490)5.67112872
20regulation of retinoic acid receptor signaling pathway (GO:0048385)5.62055286
21cellular sodium ion homeostasis (GO:0006883)5.50208295
22negative regulation of cAMP-mediated signaling (GO:0043951)5.39761195
23epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.34951515
24locomotory exploration behavior (GO:0035641)5.23786618
25ribosomal small subunit biogenesis (GO:0042274)5.12546538
26male meiosis (GO:0007140)5.09009936
27heart valve morphogenesis (GO:0003179)4.96862116
28cGMP biosynthetic process (GO:0006182)4.92854862
29regulation of corticosteroid hormone secretion (GO:2000846)4.87819543
30parturition (GO:0007567)4.81120604
31endocrine hormone secretion (GO:0060986)4.80019157
32notochord development (GO:0030903)4.79999624
33apoptotic DNA fragmentation (GO:0006309)4.72431229
34sensory perception of sound (GO:0007605)4.65044950
35neuronal stem cell maintenance (GO:0097150)4.63490946
36aorta morphogenesis (GO:0035909)4.61856955
37cardiac right ventricle morphogenesis (GO:0003215)4.61627761
38sensory perception of mechanical stimulus (GO:0050954)4.59441760
39chaperone mediated protein folding requiring cofactor (GO:0051085)4.49999835
40activin receptor signaling pathway (GO:0032924)4.48407812
41positive regulation of lamellipodium assembly (GO:0010592)4.47876197
42regulation of female gonad development (GO:2000194)4.46940042
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.46307757
44regulation of glucocorticoid secretion (GO:2000849)4.41665134
45mitochondrial genome maintenance (GO:0000002)4.36163138
46urinary tract smooth muscle contraction (GO:0014848)4.35503025
47positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)4.33160985
48mitochondrial RNA metabolic process (GO:0000959)4.33007139
49type B pancreatic cell proliferation (GO:0044342)4.29335962
50prenylation (GO:0097354)4.25396453
51protein prenylation (GO:0018342)4.25396453
52endothelial cell differentiation (GO:0045446)4.21073364
53auditory receptor cell stereocilium organization (GO:0060088)4.19431321
54atrioventricular valve morphogenesis (GO:0003181)4.14381606
55rRNA modification (GO:0000154)4.09432135
56cardiac ventricle morphogenesis (GO:0003208)4.08876577
57nephron tubule development (GO:0072080)4.05844893
58seminiferous tubule development (GO:0072520)4.04123541
59maturation of 5.8S rRNA (GO:0000460)3.98951919
60preassembly of GPI anchor in ER membrane (GO:0016254)3.98444935
61mitochondrial DNA replication (GO:0006264)3.97993635
62aggressive behavior (GO:0002118)3.96756397
63RNA methylation (GO:0001510)3.93201872
64behavioral response to ethanol (GO:0048149)3.92529460
65tRNA modification (GO:0006400)3.89619258
66relaxation of smooth muscle (GO:0044557)3.86555381
67mismatch repair (GO:0006298)3.85430912
68cardiac chamber morphogenesis (GO:0003206)3.82449719
69rRNA methylation (GO:0031167)3.81957630
70ribosomal small subunit assembly (GO:0000028)3.80459223
71Arp2/3 complex-mediated actin nucleation (GO:0034314)3.78711936
72peristalsis (GO:0030432)3.75978284
73anterograde synaptic vesicle transport (GO:0048490)3.75772475
74interferon-gamma secretion (GO:0072643)3.74980132
75pyrimidine nucleotide catabolic process (GO:0006244)3.74523088
76regulation of Notch signaling pathway (GO:0008593)3.73133579
77negative regulation of microtubule polymerization (GO:0031115)3.72296232
78heart valve formation (GO:0003188)3.71843855
79regulation of female receptivity (GO:0045924)3.71742764
80vitamin catabolic process (GO:0009111)3.71216521
81fat-soluble vitamin catabolic process (GO:0042363)3.71216521
82DNA damage induced protein phosphorylation (GO:0006975)3.69958522
83ribosomal large subunit biogenesis (GO:0042273)3.68710875
84behavioral response to pain (GO:0048266)3.67481513
85gap junction assembly (GO:0016264)3.66322152
86neuroblast proliferation (GO:0007405)3.65645168
87pseudouridine synthesis (GO:0001522)3.65151426
88ovarian follicle development (GO:0001541)3.64821157
89membrane budding (GO:0006900)3.64477825
90lipopolysaccharide biosynthetic process (GO:0009103)3.63849283
91cysteine metabolic process (GO:0006534)3.63689096
92positive regulation of lamellipodium organization (GO:1902745)3.63526188
93ventricular septum morphogenesis (GO:0060412)3.63108748
94N-glycan processing (GO:0006491)3.61226330
95cardiac epithelial to mesenchymal transition (GO:0060317)3.57761300
96regulation of voltage-gated calcium channel activity (GO:1901385)3.53612514
97cell wall macromolecule catabolic process (GO:0016998)3.52240659
98regulation of steroid hormone secretion (GO:2000831)3.51727797
99DNA strand renaturation (GO:0000733)3.50262910
100positive regulation of skeletal muscle tissue development (GO:0048643)3.48537978
101very-low-density lipoprotein particle assembly (GO:0034379)3.45835589
102renal tubule development (GO:0061326)3.44971967
103ribonucleoprotein complex disassembly (GO:0032988)3.43127261
104response to muramyl dipeptide (GO:0032495)3.43058593
105maturation of SSU-rRNA (GO:0030490)3.41563656
106positive regulation of protein oligomerization (GO:0032461)3.38737403
107oxidative demethylation (GO:0070989)3.37202672
108actin nucleation (GO:0045010)3.36458220
109termination of RNA polymerase III transcription (GO:0006386)3.35406173
110transcription elongation from RNA polymerase III promoter (GO:0006385)3.35406173
111regulation of rhodopsin mediated signaling pathway (GO:0022400)3.33574527
112snRNA transcription (GO:0009301)3.33509909
113regulation of cardioblast proliferation (GO:0003264)3.31519278
114regulation of secondary heart field cardioblast proliferation (GO:0003266)3.31519278
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30473954
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30473954
117morphogenesis of an epithelial sheet (GO:0002011)3.29312558
118behavioral response to nicotine (GO:0035095)3.28784119
119nephron epithelium development (GO:0072009)3.28584925
120positive regulation of mast cell activation involved in immune response (GO:0033008)3.28081791
121positive regulation of mast cell degranulation (GO:0043306)3.28081791
122N-acetylneuraminate metabolic process (GO:0006054)3.27225005
123regulation of skeletal muscle cell differentiation (GO:2001014)3.27086252
124SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.25822259
125positive regulation of prostaglandin secretion (GO:0032308)3.24349487
126male meiosis I (GO:0007141)3.23694959
127GMP metabolic process (GO:0046037)3.23456325
128male genitalia development (GO:0030539)3.23322921
129TOR signaling (GO:0031929)3.23127619
130positive regulation of hormone metabolic process (GO:0032352)3.23085324
131valine metabolic process (GO:0006573)3.23063612
132cochlea development (GO:0090102)3.23042843
133regulation of lipoprotein metabolic process (GO:0050746)3.21477605
134DNA demethylation (GO:0080111)3.20323854
135mannosylation (GO:0097502)3.19043429
136peptidyl-glutamic acid modification (GO:0018200)3.17480709
137phasic smooth muscle contraction (GO:0014821)3.15859583
138sodium ion homeostasis (GO:0055078)3.14868867
139DNA dealkylation (GO:0035510)3.14807022
140nonmotile primary cilium assembly (GO:0035058)3.14689825
141cell wall macromolecule metabolic process (GO:0044036)3.14110186
142positive regulation of hormone biosynthetic process (GO:0046886)3.13919993
143positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.13376051
144regulation of mitochondrial translation (GO:0070129)3.12757557
145lipopolysaccharide metabolic process (GO:0008653)3.12679982
146positive thymic T cell selection (GO:0045059)3.12677154
147pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11505728
148mitochondrial DNA metabolic process (GO:0032042)3.11467925
149regulation of histone H3-K27 methylation (GO:0061085)3.10026528
150lens fiber cell development (GO:0070307)3.09456481
151rRNA processing (GO:0006364)3.09281151
152positive regulation of endothelial cell differentiation (GO:0045603)3.08902640
153negative regulation of catecholamine secretion (GO:0033604)3.08519073
154regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)3.08033222
155cGMP metabolic process (GO:0046068)3.07933777
156protein targeting to lysosome (GO:0006622)3.06735461
157establishment of protein localization to vacuole (GO:0072666)3.06735461
158protein targeting to vacuole (GO:0006623)3.06735461
159negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.05471755
160protein import into peroxisome matrix (GO:0016558)3.04396998
161galactose metabolic process (GO:0006012)3.03725637
162female mating behavior (GO:0060180)3.03619529
163galactose catabolic process (GO:0019388)3.02940252
164regulation of protein homooligomerization (GO:0032462)3.02606944
165rRNA metabolic process (GO:0016072)3.01591730
166negative regulation of leukocyte chemotaxis (GO:0002689)3.00317788
167cell surface receptor signaling pathway involved in heart development (GO:0061311)2.98108545
168negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.96271931
169behavioral response to cocaine (GO:0048148)2.94673075
170positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93946941
171rhodopsin mediated signaling pathway (GO:0016056)2.93772043
172stem cell development (GO:0048864)2.93702011
173hyperosmotic salinity response (GO:0042538)2.92876551
174ventricular trabecula myocardium morphogenesis (GO:0003222)2.92228825
1752-oxoglutarate metabolic process (GO:0006103)2.92057381
176generation of neurons (GO:0048699)2.92009137
177endothelium development (GO:0003158)2.91878487
178oxaloacetate metabolic process (GO:0006107)2.90984005
179neuron remodeling (GO:0016322)2.90952283
180skeletal muscle tissue regeneration (GO:0043403)2.90909694
181organ formation (GO:0048645)2.89670188
182lung epithelium development (GO:0060428)2.89262894
183thyroid gland development (GO:0030878)2.84765281
184DNA deamination (GO:0045006)2.84717414
185neuromuscular synaptic transmission (GO:0007274)2.84695715
186immunoglobulin mediated immune response (GO:0016064)2.84539809
187photoreceptor cell maintenance (GO:0045494)2.83871280
188glomerulus development (GO:0032835)2.83800512
189thrombin receptor signaling pathway (GO:0070493)2.83717542
190NAD biosynthetic process (GO:0009435)2.82461645
191viral transcription (GO:0019083)2.81618484
192dicarboxylic acid catabolic process (GO:0043649)2.79747804
193positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.79409851
194myoblast differentiation (GO:0045445)2.78551727
195negative regulation of execution phase of apoptosis (GO:1900118)2.76494929
196RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75886371
197negative regulation of transcription by competitive promoter binding (GO:0010944)2.75855048
198regulation of somitogenesis (GO:0014807)12.9525445
199pentose metabolic process (GO:0019321)12.2067237
200auditory receptor cell differentiation (GO:0042491)10.2700364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.88272334
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.64840164
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.17188775
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.14418179
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.61888187
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.58021404
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.47176300
8ERG_21242973_ChIP-ChIP_JURKAT_Human3.13985607
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07533550
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.05007707
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94166564
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.81414452
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.68545303
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.61004913
15STAT1_20625510_ChIP-Seq_HELA_Human2.53496008
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.52187981
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43424121
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43424121
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37670510
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.35377954
21EZH2_22144423_ChIP-Seq_EOC_Human2.32672582
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.27268807
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20373206
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.15668017
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14060376
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.13085819
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.06389058
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06302847
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04637171
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.03358705
31VDR_23849224_ChIP-Seq_CD4+_Human2.00206001
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98399654
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98009332
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.97032773
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96784372
36FOXP3_21729870_ChIP-Seq_TREG_Human1.93783015
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90959433
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.89782618
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88879207
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85999893
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85980850
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85642472
43GABP_19822575_ChIP-Seq_HepG2_Human1.82796810
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.80794360
45CIITA_25753668_ChIP-Seq_RAJI_Human1.79285448
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74916568
47DCP1A_22483619_ChIP-Seq_HELA_Human1.70307685
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70132103
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.68982153
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68251131
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67405956
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66939082
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66939082
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66895244
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.66441363
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.65689458
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62584753
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60960050
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.60751125
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58597013
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58442574
62AHR_22903824_ChIP-Seq_MCF-7_Human1.58420438
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58059339
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56750785
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55021584
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53148133
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.52206113
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.51415730
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48761713
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.47125314
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46315640
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45937161
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.45922616
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.45629854
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.44568848
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44081259
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43365931
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41128067
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.40644994
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39503732
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.39124494
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.38844752
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38083825
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37263341
85TFEB_21752829_ChIP-Seq_HELA_Human1.37214662
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37004194
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36650581
88KDM2B_26808549_Chip-Seq_K562_Human1.36291136
89CLOCK_20551151_ChIP-Seq_293T_Human1.36047397
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35443067
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35054592
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34709333
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33958562
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33734777
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31802173
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.30500534
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30308095
98ZNF263_19887448_ChIP-Seq_K562_Human1.29057664
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28985310
100E2F1_20622854_ChIP-Seq_HELA_Human1.28978601
101TTF2_22483619_ChIP-Seq_HELA_Human1.28158391
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.26777004
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26415429
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26384345
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25300836
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25300836
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25300836
108XRN2_22483619_ChIP-Seq_HELA_Human1.23744880
109SCL_19346495_ChIP-Seq_HPC-7_Human1.23102392
110DROSHA_22980978_ChIP-Seq_HELA_Human1.23046424
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22570413
112CTCF_20526341_ChIP-Seq_ESCs_Human1.20270822
113GATA3_24758297_ChIP-Seq_MCF-7_Human1.19641299
114SPI1_23547873_ChIP-Seq_NB4_Human1.18798043
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17109642
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15180777
117E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15114463
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14771809
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14596211
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.14043992
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13485040
122TP53_22573176_ChIP-Seq_HFKS_Human1.13394136
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13226047
124MYB_26560356_Chip-Seq_TH2_Human1.12745063
125PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12165990
126LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11865171
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10758062
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10487017
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09592391
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09041840
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.08430922
132CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07703507
133ISL1_27105846_Chip-Seq_CPCs_Mouse1.07645236
134FOXP1_21924763_ChIP-Seq_HESCs_Human1.06236338
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05501508
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03825643
137GATA3_26560356_Chip-Seq_TH2_Human1.03671144
138CTCF_26484167_Chip-Seq_Bcells_Mouse1.03047000
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02452608
140TAF15_26573619_Chip-Seq_HEK293_Human1.02323432
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01981564
142BCOR_27268052_Chip-Seq_Bcells_Human1.01501948
143P300_27268052_Chip-Seq_Bcells_Human1.01400271
144KDM5A_27292631_Chip-Seq_BREAST_Human1.01221839
145ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01160622
146PHF8_20622854_ChIP-Seq_HELA_Human1.00913995
147SOX2_21211035_ChIP-Seq_LN229_Human1.00649435
148P68_20966046_ChIP-Seq_HELA_Human1.00618427
149RXR_22158963_ChIP-Seq_LIVER_Mouse1.00328925
150BCL6_27268052_Chip-Seq_Bcells_Human1.00266669
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99808601
152PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99641299
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99254305
154VDR_24787735_ChIP-Seq_THP-1_Human0.99096615
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98814138
156E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98711435
157ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98072684
158CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98015234
159PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97220021
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96591671
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96433887
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.96326313
163CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96256560
164ERA_21632823_ChIP-Seq_H3396_Human0.96089985
165VDR_21846776_ChIP-Seq_THP-1_Human0.96002983
166SOX2_20726797_ChIP-Seq_SW620_Human0.94931911
167CTCF_27219007_Chip-Seq_Bcells_Human0.94822914
168FOXA2_19822575_ChIP-Seq_HepG2_Human0.92797543
169AR_21909140_ChIP-Seq_LNCAP_Human0.92266392
170ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90967396
171ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90701914
172LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90526688
173LXR_22292898_ChIP-Seq_THP-1_Human0.87943264
174KDM2B_26808549_Chip-Seq_JURKAT_Human0.86536201
175CREB1_26743006_Chip-Seq_LNCaP_Human0.85773228
176EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85278149
177TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84388064
178DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83933107
179NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83856849
180STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83855292
181KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83353646
182NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82238699
183KLF5_25053715_ChIP-Seq_YYC3_Human0.81722040
184THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80585773
185SOX2_21211035_ChIP-Seq_LN229_Gbm0.78999348
186TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78606062
187ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77451625
188BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77447601
189E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.77210318
190ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77079593
191CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76906316
192KDM2B_26808549_Chip-Seq_DND41_Human0.76116326
193PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75914306
194NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75309962
195SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74563597
196KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73458136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot8.25261861
2MP0003878_abnormal_ear_physiology8.25261861
3MP0002653_abnormal_ependyma_morphology6.76536687
4MP0000569_abnormal_digit_pigmentation6.67379940
5MP0001485_abnormal_pinna_reflex6.17930902
6MP0003879_abnormal_hair_cell4.93806215
7MP0001986_abnormal_taste_sensitivity4.57847993
8MP0008260_abnormal_autophagy4.15840624
9MP0005423_abnormal_somatic_nervous3.81490037
10MP0001963_abnormal_hearing_physiology3.51401244
11MP0000026_abnormal_inner_ear3.33221982
12MP0009333_abnormal_splenocyte_physiolog3.06387650
13MP0008789_abnormal_olfactory_epithelium3.03699459
14MP0009278_abnormal_bone_marrow2.91914329
15MP0001984_abnormal_olfaction2.79611672
16MP0003172_abnormal_lysosome_physiology2.77862699
17MP0003718_maternal_effect2.75623077
18MP0006292_abnormal_olfactory_placode2.66789128
19MP0005174_abnormal_tail_pigmentation2.52731228
20MP0001545_abnormal_hematopoietic_system2.45579074
21MP0005397_hematopoietic_system_phenotyp2.45579074
22MP0003303_peritoneal_inflammation2.42313078
23MP0005394_taste/olfaction_phenotype2.37637014
24MP0005499_abnormal_olfactory_system2.37637014
25MP0004885_abnormal_endolymph2.37303428
26MP0000049_abnormal_middle_ear2.20182523
27MP0005451_abnormal_body_composition2.09083028
28MP0002932_abnormal_joint_morphology2.05932481
29MP0005508_abnormal_skeleton_morphology2.00189982
30MP0005075_abnormal_melanosome_morpholog1.75990570
31MP0003191_abnormal_cellular_cholesterol1.72967390
32MP0003724_increased_susceptibility_to1.72200627
33MP0003111_abnormal_nucleus_morphology1.72084316
34MP0000566_synostosis1.70409351
35MP0009780_abnormal_chondrocyte_physiolo1.68876485
36MP0000681_abnormal_thyroid_gland1.64164217
37MP0008007_abnormal_cellular_replicative1.63390099
38MP0004782_abnormal_surfactant_physiolog1.60602995
39MP0006035_abnormal_mitochondrial_morpho1.58994877
40MP0004134_abnormal_chest_morphology1.49706446
41MP0003186_abnormal_redox_activity1.47297360
42MP0003941_abnormal_skin_development1.44358294
43MP0002269_muscular_atrophy1.44349651
44MP0002332_abnormal_exercise_endurance1.42928582
45MP0004264_abnormal_extraembryonic_tissu1.41910127
46MP0000015_abnormal_ear_pigmentation1.39411143
47MP0002132_abnormal_respiratory_system1.37000430
48MP0001853_heart_inflammation1.36508575
49MP0009379_abnormal_foot_pigmentation1.36083810
50MP0008057_abnormal_DNA_replication1.33384701
51MP0003436_decreased_susceptibility_to1.28421706
52MP0000579_abnormal_nail_morphology1.25064103
53MP0003115_abnormal_respiratory_system1.23547496
54MP0005085_abnormal_gallbladder_physiolo1.21840348
55MP0004808_abnormal_hematopoietic_stem1.20946985
56MP0010234_abnormal_vibrissa_follicle1.19533599
57MP0000534_abnormal_ureter_morphology1.19198393
58MP0000358_abnormal_cell_content/1.16569246
59MP0002089_abnormal_postnatal_growth/wei1.15528673
60MP0002396_abnormal_hematopoietic_system1.15036344
61MP0002249_abnormal_larynx_morphology1.10645976
62MP0005360_urolithiasis1.10582633
63MP0006036_abnormal_mitochondrial_physio1.09486229
64MP0003453_abnormal_keratinocyte_physiol1.09306822
65MP0003950_abnormal_plasma_membrane1.07707087
66MP0005310_abnormal_salivary_gland1.05099310
67MP0003252_abnormal_bile_duct1.05046665
68MP0002752_abnormal_somatic_nervous1.03269258
69MP0003646_muscle_fatigue1.02493001
70MP0003705_abnormal_hypodermis_morpholog1.02445629
71MP0002148_abnormal_hypersensitivity_rea1.01219295
72MP0000647_abnormal_sebaceous_gland1.01028701
73MP0000762_abnormal_tongue_morphology1.00284882
74MP0003693_abnormal_embryo_hatching0.99876312
75MP0003828_pulmonary_edema0.99518589
76MP0002019_abnormal_tumor_incidence0.98854499
77MP0001764_abnormal_homeostasis0.97794997
78MP0000371_diluted_coat_color0.96686392
79MP0000163_abnormal_cartilage_morphology0.95655456
80MP0003077_abnormal_cell_cycle0.95326596
81MP0001486_abnormal_startle_reflex0.95246854
82MP0002233_abnormal_nose_morphology0.95095352
83MP0005220_abnormal_exocrine_pancreas0.94344338
84MP0010678_abnormal_skin_adnexa0.94207658
85MP0005645_abnormal_hypothalamus_physiol0.93820106
86MP0003942_abnormal_urinary_system0.92371934
87MP0002115_abnormal_skeleton_extremities0.91998908
88MP0001881_abnormal_mammary_gland0.90900019
89MP0001905_abnormal_dopamine_level0.90228166
90MP0002111_abnormal_tail_morphology0.88990722
91MP0001286_abnormal_eye_development0.87757995
92MP0005390_skeleton_phenotype0.86301058
93MP0001293_anophthalmia0.86232202
94MP0000383_abnormal_hair_follicle0.84478981
95MP0004043_abnormal_pH_regulation0.84246438
96MP0004742_abnormal_vestibular_system0.81873279
97MP0002638_abnormal_pupillary_reflex0.80353687
98MP0005195_abnormal_posterior_eye0.78595135
99MP0002090_abnormal_vision0.77985869
100MP0000778_abnormal_nervous_system0.77526513
101MP0004130_abnormal_muscle_cell0.77329106
102MP0000490_abnormal_crypts_of0.76950392
103MP0001835_abnormal_antigen_presentation0.75888997
104MP0000678_abnormal_parathyroid_gland0.75342812
105MP0000733_abnormal_muscle_development0.75318126
106MP0000604_amyloidosis0.74973078
107MP0000716_abnormal_immune_system0.74076761
108MP0005083_abnormal_biliary_tract0.74076076
109MP0002405_respiratory_system_inflammati0.74068235
110MP0002139_abnormal_hepatobiliary_system0.73112050
111MP0003806_abnormal_nucleotide_metabolis0.71167538
112MP0005647_abnormal_sex_gland0.70766392
113MP0002452_abnormal_antigen_presenting0.70692450
114MP0002429_abnormal_blood_cell0.70540052
115MP0004233_abnormal_muscle_weight0.70165818
116MP0009046_muscle_twitch0.69043054
117MP0000230_abnormal_systemic_arterial0.69020552
118MP0008058_abnormal_DNA_repair0.68288448
119MP0002277_abnormal_respiratory_mucosa0.67553894
120MP0002282_abnormal_trachea_morphology0.67529900
121MP0005410_abnormal_fertilization0.66710317
122MP0002160_abnormal_reproductive_system0.66633034
123MP0005464_abnormal_platelet_physiology0.66354450
124MP0010155_abnormal_intestine_physiology0.66240082
125MP0003283_abnormal_digestive_organ0.65965627
126MP0003938_abnormal_ear_development0.65405206
127MP0010386_abnormal_urinary_bladder0.64992004
128MP0002116_abnormal_craniofacial_bone0.64774731
129MP0005319_abnormal_enzyme/_coenzyme0.64749736
130MP0000313_abnormal_cell_death0.64239480
131MP0001664_abnormal_digestion0.63886993
132MP0008875_abnormal_xenobiotic_pharmacok0.63616977
133MP0002796_impaired_skin_barrier0.63280496
134MP0002723_abnormal_immune_serum0.62975214
135MP0009840_abnormal_foam_cell0.62565644
136MP0001929_abnormal_gametogenesis0.62525578
137MP0005408_hypopigmentation0.61880660
138MP0003959_abnormal_lean_body0.61715633
139MP0000689_abnormal_spleen_morphology0.61621028
140MP0004957_abnormal_blastocyst_morpholog0.61534774
141MP0002419_abnormal_innate_immunity0.60775962
142MP0001849_ear_inflammation0.60027684
143MP0002109_abnormal_limb_morphology0.59396297
144MP0003656_abnormal_erythrocyte_physiolo0.59361702
145MP0000428_abnormal_craniofacial_morphol0.58431624
146MP0000750_abnormal_muscle_regeneration0.58246279
147MP0003123_paternal_imprinting0.57259016
148MP0008770_decreased_survivor_rate0.56351130
149MP0002102_abnormal_ear_morphology0.56348522
150MP0005395_other_phenotype0.56186682
151MP0004381_abnormal_hair_follicle0.55945596
152MP0009250_abnormal_appendicular_skeleto0.55737969
153MP0001800_abnormal_humoral_immune0.54980547
154MP0002075_abnormal_coat/hair_pigmentati0.54869518
155MP0000470_abnormal_stomach_morphology0.54838495
156MP0005636_abnormal_mineral_homeostasis0.54070356
157MP0001915_intracranial_hemorrhage0.52470435
158MP0010030_abnormal_orbit_morphology0.52029376
159MP0002113_abnormal_skeleton_development0.51865817
160MP0001299_abnormal_eye_distance/0.50337167
161MP0005365_abnormal_bile_salt0.48901716
162MP0000631_abnormal_neuroendocrine_gland0.45745971
163MP0009703_decreased_birth_body0.44067698
164MP0002229_neurodegeneration0.43648821
165MP0005623_abnormal_meninges_morphology0.42612881
166MP0001958_emphysema0.42387341
167MP0004272_abnormal_basement_membrane0.42159239
168MP0003699_abnormal_female_reproductive0.40887618
169MP0000639_abnormal_adrenal_gland0.40833330
170MP0001346_abnormal_lacrimal_gland0.40496363
171MP0009053_abnormal_anal_canal0.39616826
172MP0003566_abnormal_cell_adhesion0.39501402
173MP0000767_abnormal_smooth_muscle0.39312383
174MP0002882_abnormal_neuron_morphology0.38855246
175MP0005058_abnormal_lysosome_morphology0.38787944
176MP0000613_abnormal_salivary_gland0.37421054
177MP0003861_abnormal_nervous_system0.37394917
178MP0009384_cardiac_valve_regurgitation0.37046200
179MP0001119_abnormal_female_reproductive0.36441402
180MP0001175_abnormal_lung_morphology0.36232235
181MP0001340_abnormal_eyelid_morphology0.36174653
182MP0004859_abnormal_synaptic_plasticity0.35589976
183MP0002085_abnormal_embryonic_tissue0.35315821
184MP0002184_abnormal_innervation0.34615128
185MP0001270_distended_abdomen0.34477505
186MP0000432_abnormal_head_morphology0.34349483
187MP0002822_catalepsy0.33829521
188MP0002009_preneoplasia0.33677716
189MP0002928_abnormal_bile_duct0.33492620

Predicted human phenotypes

RankGene SetZ-score
1Mixed hearing impairment (HP:0000410)8.71482562
2Unilateral renal agenesis (HP:0000122)8.07113856
3Hypoplasia of the fovea (HP:0007750)7.44835130
4Aplasia/Hypoplasia of the fovea (HP:0008060)7.44835130
5Absent rod-and cone-mediated responses on ERG (HP:0007688)7.36955350
6Decreased electroretinogram (ERG) amplitude (HP:0000654)7.33155047
7Anomalous pulmonary venous return (HP:0010772)7.28203251
8Bilateral microphthalmos (HP:0007633)7.04911953
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.87464937
10Cone-rod dystrophy (HP:0000548)6.86067859
11Bell-shaped thorax (HP:0001591)6.57478258
12Abnormality of the pulmonary veins (HP:0011718)6.37685588
13Abnormality of the fovea (HP:0000493)6.23704150
14Hypoplastic ischia (HP:0003175)6.11516309
15Epiphyseal dysplasia (HP:0002656)6.09151022
16Focal motor seizures (HP:0011153)5.89444683
17Visual hallucinations (HP:0002367)5.62164108
18Abnormality of the ischium (HP:0003174)5.50928927
19Abnormal number of erythroid precursors (HP:0012131)5.46616629
20Abnormal rod and cone electroretinograms (HP:0008323)5.24321351
21Fused cervical vertebrae (HP:0002949)5.17116431
22Aplasia/Hypoplasia of the macula (HP:0008059)5.10742423
23Abnormality of cells of the erythroid lineage (HP:0012130)5.01758400
24Progressive muscle weakness (HP:0003323)4.81600781
25Aplasia/Hypoplasia affecting the retina (HP:0008061)4.71498841
26Abnormal vertebral ossification (HP:0100569)4.70182028
27Increased corneal curvature (HP:0100692)4.50106262
28Keratoconus (HP:0000563)4.50106262
29Abnormality of the pubic bones (HP:0003172)4.34997759
30Abnormality of the intervertebral disk (HP:0005108)4.07540165
31Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06736566
32Enlarged epiphyses (HP:0010580)3.91618539
33Attenuation of retinal blood vessels (HP:0007843)3.89647471
34Multifactorial inheritance (HP:0001426)3.89434029
35Vertebral clefting (HP:0008428)3.87494037
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.73518692
37Absent epiphyses (HP:0010577)3.73518692
38Prolonged neonatal jaundice (HP:0006579)3.71919701
39Cerebellar dysplasia (HP:0007033)3.69115163
40Congenital sensorineural hearing impairment (HP:0008527)3.67264173
41Humeroradial synostosis (HP:0003041)3.38922524
42Synostosis involving the elbow (HP:0003938)3.38922524
43Recurrent corneal erosions (HP:0000495)3.36833354
44Turricephaly (HP:0000262)3.33421885
45Sprengel anomaly (HP:0000912)3.33003077
46Bony spicule pigmentary retinopathy (HP:0007737)3.20167210
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.20158908
48Increased serum ferritin (HP:0003281)3.18443827
49Hypochromic anemia (HP:0001931)3.10704347
50Protuberant abdomen (HP:0001538)2.93034396
51Seborrheic dermatitis (HP:0001051)2.92822684
52Abnormality of midbrain morphology (HP:0002418)2.89964519
53Molar tooth sign on MRI (HP:0002419)2.89964519
54Absence seizures (HP:0002121)2.89467823
55Absent eyelashes (HP:0000561)2.88502469
56Type 2 muscle fiber atrophy (HP:0003554)2.87585961
57Vitreoretinal degeneration (HP:0000655)2.86083360
58Dialeptic seizures (HP:0011146)2.82856806
59Abnormality of iron homeostasis (HP:0011031)2.82453858
60Severe Myopia (HP:0011003)2.72556477
61Abnormality of transition element cation homeostasis (HP:0011030)2.70212842
62Ectopic anus (HP:0004397)2.67241151
63Alopecia of scalp (HP:0002293)2.65778305
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64336859
65Type II lissencephaly (HP:0007260)2.62792922
66Progressive external ophthalmoplegia (HP:0000590)2.61765265
67Dicarboxylic aciduria (HP:0003215)2.57842833
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57842833
69Hypertensive crisis (HP:0100735)2.51620398
70Ependymoma (HP:0002888)2.49300651
71Focal seizures (HP:0007359)2.48765312
72Glossoptosis (HP:0000162)2.48041490
73Acute hepatic failure (HP:0006554)2.46806718
74Truncus arteriosus (HP:0001660)2.39818012
75Abnormality of serum amino acid levels (HP:0003112)2.38772660
76Synostosis of carpal bones (HP:0005048)2.37159915
77Exostoses (HP:0100777)2.35781444
78Muscle fiber atrophy (HP:0100295)2.34112577
79Aplasia involving bones of the extremities (HP:0009825)2.27369363
80Aplasia involving bones of the upper limbs (HP:0009823)2.27369363
81Aplasia of the phalanges of the hand (HP:0009802)2.27369363
82Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.24812485
83Meningocele (HP:0002435)2.21920586
84Generalized amyotrophy (HP:0003700)2.20754000
85Flared metaphyses (HP:0003015)2.20054985
86Irregular epiphyses (HP:0010582)2.19457594
87Methylmalonic aciduria (HP:0012120)2.18338079
88Platyspondyly (HP:0000926)2.13850119
89Macular degeneration (HP:0000608)2.12582392
90Tinnitus (HP:0000360)2.12027006
91Progressive neurologic deterioration (HP:0002344)2.09729981
92Chest pain (HP:0100749)2.08539085
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06328390
94Thrombocytosis (HP:0001894)2.04729743
95Hyperthyroidism (HP:0000836)2.04346169
96Oligodactyly (HP:0012165)2.04070121
97Exercise intolerance (HP:0003546)2.02223690
98Vertebral fusion (HP:0002948)2.02174188
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00317251
100Microvesicular hepatic steatosis (HP:0001414)11.3596985
101Decreased central vision (HP:0007663)10.9842662
102Alacrima (HP:0000522)1.98428702
103Abnormality of liposaccharide metabolism (HP:0010968)1.96526162
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.96526162
105Abnormality of glycolipid metabolism (HP:0010969)1.96526162
106Renal dysplasia (HP:0000110)1.94096330
107Lip pit (HP:0100267)1.93374312
108Atelectasis (HP:0100750)1.92357153
109Albinism (HP:0001022)1.91723217
110Fasciculations (HP:0002380)1.91168277
111Widely patent fontanelles and sutures (HP:0004492)1.89524883
112Mild short stature (HP:0003502)1.89431142
113Osteoarthritis (HP:0002758)1.88922586
114Abnormality of the renal medulla (HP:0100957)1.88854805
115Obstructive lung disease (HP:0006536)1.88821612
116Chronic obstructive pulmonary disease (HP:0006510)1.88821612
117Partial duplication of thumb phalanx (HP:0009944)1.88743839
118Autoamputation (HP:0001218)1.87923492
119Retinal dysplasia (HP:0007973)1.86876692
120Poikiloderma (HP:0001029)1.86674184
121Spastic tetraparesis (HP:0001285)1.86099902
122Basal cell carcinoma (HP:0002671)1.84641132
123Abnormality of B cell number (HP:0010975)1.84133634
124Neoplasm of head and neck (HP:0012288)1.83861550
125Esophageal neoplasm (HP:0100751)1.83861550
126Constricted visual fields (HP:0001133)1.82649964
127Abnormality of the vitreous humor (HP:0004327)1.80883699
128Nephronophthisis (HP:0000090)1.80857852
129Flat capital femoral epiphysis (HP:0003370)1.79526551
130Hypoplastic pelvis (HP:0008839)1.78692845
131Papillary thyroid carcinoma (HP:0002895)1.78373604
132Vertebral arch anomaly (HP:0008438)1.77861757
133Carpal synostosis (HP:0009702)1.77789676
134Autoimmune thrombocytopenia (HP:0001973)1.76848764
135Abnormality of the pons (HP:0007361)1.76671723
136Arterial tortuosity (HP:0005116)1.76245787
137Preauricular pit (HP:0004467)1.75697656
138Periauricular skin pits (HP:0100277)1.75697656
139Knee flexion contracture (HP:0006380)1.75534469
140Hypoplastic ilia (HP:0000946)1.75078787
141Keratoconjunctivitis sicca (HP:0001097)1.74343185
142Abnormality of lateral ventricle (HP:0030047)1.73281752
143Oral leukoplakia (HP:0002745)1.72123503
144Autoimmune hemolytic anemia (HP:0001890)1.70105938
145Partial duplication of the phalanx of hand (HP:0009999)1.69702762
146Abnormality of placental membranes (HP:0011409)1.67807216
147Amniotic constriction ring (HP:0009775)1.67807216
148Increased serum lactate (HP:0002151)1.67502655
149External ophthalmoplegia (HP:0000544)1.67407497
150Acute lymphatic leukemia (HP:0006721)1.66925838
151Renal agenesis (HP:0000104)1.66713350
152Congenital stationary night blindness (HP:0007642)1.66284669
153Decreased lacrimation (HP:0000633)1.65807337
154Abnormality of the lacrimal duct (HP:0011481)1.64543139
155Dysphonia (HP:0001618)1.64386091
156Male infertility (HP:0003251)1.64049036
157Short thorax (HP:0010306)1.63944408
158Abnormality of the salivary glands (HP:0010286)1.63789275
159Xerostomia (HP:0000217)1.62534398
160Easy fatigability (HP:0003388)1.61486831
161Renal cortical cysts (HP:0000803)1.59292774
162Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.59289658
163Delayed CNS myelination (HP:0002188)1.58542642
164Pulmonary fibrosis (HP:0002206)1.58186131
165Short tibia (HP:0005736)1.57715879
166Cerebral edema (HP:0002181)1.56527008
167Neoplasm of the heart (HP:0100544)1.56384610
168Metatarsus adductus (HP:0001840)1.56128776
169Abnormal umbilical cord blood vessels (HP:0011403)1.55429910
170Single umbilical artery (HP:0001195)1.55429910
171Abnormality of the fetal cardiovascular system (HP:0010948)1.55429910
172Delayed epiphyseal ossification (HP:0002663)1.55075216
173Childhood onset (HP:0011463)1.54494997
174Keratoconjunctivitis (HP:0001096)1.52272834
175Hypoplasia of the pons (HP:0012110)1.51673436
176Fibular aplasia (HP:0002990)1.50932223
177Morphological abnormality of the inner ear (HP:0011390)1.49212560
178Pallor (HP:0000980)1.48588073
179Split foot (HP:0001839)1.48359996
180Increased cerebral lipofuscin (HP:0011813)1.48322888
181Vascular tortuosity (HP:0004948)1.47573118
182Aplasia/hypoplasia of the humerus (HP:0006507)1.47504512
183Stereotypic behavior (HP:0000733)1.47280698
184Abnormality of the phalanges of the hallux (HP:0010057)1.46841915
185Abnormality of the nasolacrimal system (HP:0000614)1.46761504
186Abdominal distention (HP:0003270)1.46641745
187Neonatal short-limb short stature (HP:0008921)1.46633807
188Skin nodule (HP:0200036)1.46618083
189Death in infancy (HP:0001522)1.45988729
190Concave nail (HP:0001598)1.45731087
191Lower limb asymmetry (HP:0100559)1.44570252
192Short ribs (HP:0000773)1.43014214
193Abnormality of nail color (HP:0100643)1.41805129
194Squamous cell carcinoma (HP:0002860)1.41616629
195Absent hair (HP:0002298)1.41533203
196Chorioretinal atrophy (HP:0000533)1.40802760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.81663727
2ERN14.58937673
3PNCK4.16509196
4NME24.11514699
5PBK3.56816697
6EIF2AK13.16172888
7MAP2K33.08949415
8IKBKB2.86993853
9MAP2K42.57247283
10PRKD22.41470960
11JAK32.29386463
12MAPK112.27304900
13TRPM72.26326978
14PTK2B2.16487608
15AKT32.12937820
16DDR212.5919766
17LATS11.85419145
18MAP2K61.72526978
19FLT31.62562426
20TAOK31.55375533
21ZAK1.52495683
22DYRK1B1.48611094
23RPS6KA61.47525445
24EIF2AK21.47109371
25CAMK1G1.44896309
26BMPR21.43932394
27SIK11.41877522
28BRSK21.36993121
29MAP3K131.34729664
30TESK21.33420231
31TIE11.30373759
32PHKG21.30178716
33PHKG11.30178716
34YES11.28815972
35WNK41.28647837
36PIK3CG1.25898598
37STK161.24281416
38BUB11.21393087
39TNK21.12869993
40TRIB31.12196838
41LATS21.10081449
42WNK31.08641965
43ATR1.04669694
44KSR21.02208267
45UHMK11.00973849
46KDR0.99197395
47AURKA0.95324248
48EPHA20.93625866
49MKNK10.92362253
50IRAK30.91477838
51RPS6KB20.91410773
52NTRK10.89796042
53SRPK10.89630298
54MAP3K70.89298542
55MARK30.88367997
56PAK40.87694744
57TBK10.87322540
58RPS6KA10.84453936
59EPHB10.82882977
60STK38L0.81712274
61FGFR30.80482691
62PIM20.79559081
63RPS6KA50.79386157
64CDK60.79133174
65TYRO30.76846539
66BTK0.75177748
67MOS0.74686354
68STK390.72918995
69KIT0.72519872
70MKNK20.71886305
71GRK10.71623924
72TEC0.67976217
73SYK0.67276977
74PRKCH0.67175632
75DAPK20.66990416
76ERBB30.66765793
77MAPK150.66431796
78CDK90.65290554
79MATK0.65030223
80CDC70.64918161
81AURKB0.64222551
82RIPK10.62511434
83WNK10.61857656
84VRK20.61034230
85ERBB20.60881994
86PKN10.60271315
87ERBB40.58370888
88TLK10.57963804
89MAP4K10.56597886
90CAMKK20.55801036
91BRSK10.54309167
92FGR0.53686627
93AKT20.53416324
94MAPK120.52922553
95RPS6KA20.51951255
96MAP3K140.51794401
97PIM10.50292795
98RET0.49745451
99SMG10.49639984
100TAOK10.49299376
101OXSR10.49006100
102EEF2K0.48628573
103RIPK40.48259378
104MST1R0.47627343
105PAK60.47313889
106PTK60.46867764
107MAP3K90.46474203
108DYRK1A0.44988515
109STK380.44597830
110NEK60.44240250
111MAP3K40.43665405
112EPHB20.41848440
113CSNK1A1L0.41405418
114FER0.40893618
115MTOR0.40609486
116GSK3A0.39960455
117PAK20.39585524
118HIPK20.38874301
119MAPK10.38359949
120PAK30.38005660
121SCYL20.37866857
122KSR10.37525241
123PLK30.37247461
124PRKAA20.37008205
125EPHA40.36755446
126PRKAA10.36407246
127MARK20.35965099
128RAF10.35344196
129STK30.34258741
130LRRK20.34093753
131CHEK10.34078998
132GRK60.34011820
133RPS6KB10.32947864
134PRKCZ0.32885373
135PLK10.32873224
136ITK0.32448651
137ABL10.32282676
138DAPK30.31752364
139CDK80.31205873
140CAMK40.31161545
141MAP4K20.31109801
142CDK190.31101740
143CSNK2A20.30937102
144LCK0.30475845
145ADRBK20.30316779
146CSNK1G30.30133041
147PKN20.30037587
148MAPK30.29673900
149FGFR10.29401111
150CDK70.27957515
151TNIK0.27364313
152FES0.26770666
153DMPK0.26279838
154PRKD30.25706581
155CSNK1G10.25471708
156MAPKAPK50.23843238
157NME10.21038094
158NTRK30.21003745
159PRKCI0.20615923
160LMTK20.20501792
161PTK20.19809001
162RPS6KL10.19395570
163RPS6KC10.19395570
164MINK10.19354322
165IRAK20.18632921
166CSNK1G20.17691231
167SIK30.16647085
168MAP3K100.16314247
169CDK50.15553678
170CSNK1E0.14913945
171SGK10.13995865
172NUAK10.13702314
173BMX0.13588242
174ROCK20.13404290
175JAK20.13139752
176MAP2K70.12781967

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005145.50764614
2Notch signaling pathway_Homo sapiens_hsa043303.84082215
3Phototransduction_Homo sapiens_hsa047443.70776188
4Ribosome_Homo sapiens_hsa030103.68353402
5Other glycan degradation_Homo sapiens_hsa005113.53136287
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.36061721
7RNA polymerase_Homo sapiens_hsa030203.34174197
8One carbon pool by folate_Homo sapiens_hsa006703.09632692
9Hippo signaling pathway_Homo sapiens_hsa043903.09192750
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.90366714
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.87977955
12Asthma_Homo sapiens_hsa053102.78556914
13Dorso-ventral axis formation_Homo sapiens_hsa043202.67655161
14Allograft rejection_Homo sapiens_hsa053302.62659473
15TGF-beta signaling pathway_Homo sapiens_hsa043502.55500433
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40078921
17Basal cell carcinoma_Homo sapiens_hsa052172.38090377
18Regulation of autophagy_Homo sapiens_hsa041402.32719220
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24531139
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19316038
21Autoimmune thyroid disease_Homo sapiens_hsa053202.13649847
22Protein digestion and absorption_Homo sapiens_hsa049742.04891650
23Graft-versus-host disease_Homo sapiens_hsa053322.00919015
24Peroxisome_Homo sapiens_hsa041461.94750220
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92178125
26Base excision repair_Homo sapiens_hsa034101.85165064
27Sulfur relay system_Homo sapiens_hsa041221.79431521
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78980750
29Type I diabetes mellitus_Homo sapiens_hsa049401.74510969
30Pyrimidine metabolism_Homo sapiens_hsa002401.72642730
31Olfactory transduction_Homo sapiens_hsa047401.70110844
32Lysine degradation_Homo sapiens_hsa003101.69376471
33Lysosome_Homo sapiens_hsa041421.68017784
34Purine metabolism_Homo sapiens_hsa002301.65764843
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65475290
36Pentose phosphate pathway_Homo sapiens_hsa000301.57736611
37Systemic lupus erythematosus_Homo sapiens_hsa053221.57552769
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56153563
39Melanogenesis_Homo sapiens_hsa049161.53474210
40RNA transport_Homo sapiens_hsa030131.50402367
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43984920
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35221327
43ECM-receptor interaction_Homo sapiens_hsa045121.31072166
44Taste transduction_Homo sapiens_hsa047421.30601752
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29562561
46Chronic myeloid leukemia_Homo sapiens_hsa052201.29518804
47Spliceosome_Homo sapiens_hsa030401.29198203
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28568756
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.26033272
50Long-term depression_Homo sapiens_hsa047301.25553776
51Adherens junction_Homo sapiens_hsa045201.21140964
52Homologous recombination_Homo sapiens_hsa034401.20630354
53Axon guidance_Homo sapiens_hsa043601.19227560
54Fatty acid biosynthesis_Homo sapiens_hsa000611.18795726
55mTOR signaling pathway_Homo sapiens_hsa041501.12483763
56Staphylococcus aureus infection_Homo sapiens_hsa051501.12433535
57Butanoate metabolism_Homo sapiens_hsa006501.07876793
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06970179
59Rheumatoid arthritis_Homo sapiens_hsa053231.06410756
60Proteoglycans in cancer_Homo sapiens_hsa052051.04925851
61Tight junction_Homo sapiens_hsa045301.03053047
62Fatty acid degradation_Homo sapiens_hsa000711.01182333
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00200869
64ErbB signaling pathway_Homo sapiens_hsa040120.99575573
65Caffeine metabolism_Homo sapiens_hsa002320.99202144
66Arginine biosynthesis_Homo sapiens_hsa002200.99166811
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.98748323
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.98670566
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98539009
70Inositol phosphate metabolism_Homo sapiens_hsa005620.98493965
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98100904
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97941978
73Viral myocarditis_Homo sapiens_hsa054160.94930814
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92066347
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92053147
76Collecting duct acid secretion_Homo sapiens_hsa049660.91164705
77Wnt signaling pathway_Homo sapiens_hsa043100.90348226
78Ovarian steroidogenesis_Homo sapiens_hsa049130.89472415
79Fatty acid elongation_Homo sapiens_hsa000620.88156724
80Retinol metabolism_Homo sapiens_hsa008300.87049849
81Bladder cancer_Homo sapiens_hsa052190.86533632
82Fatty acid metabolism_Homo sapiens_hsa012120.83360423
83Circadian rhythm_Homo sapiens_hsa047100.80110813
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.79989317
85Nitrogen metabolism_Homo sapiens_hsa009100.79872649
86VEGF signaling pathway_Homo sapiens_hsa043700.79605170
87RNA degradation_Homo sapiens_hsa030180.77360578
88Herpes simplex infection_Homo sapiens_hsa051680.77122750
89Prion diseases_Homo sapiens_hsa050200.77052628
90Linoleic acid metabolism_Homo sapiens_hsa005910.76464882
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76200491
92Pancreatic cancer_Homo sapiens_hsa052120.76027548
93Prolactin signaling pathway_Homo sapiens_hsa049170.75624191
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75375088
95PPAR signaling pathway_Homo sapiens_hsa033200.74993610
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74447839
97Histidine metabolism_Homo sapiens_hsa003400.72782226
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72430956
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72226779
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71113324
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70815005
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.68399179
103Starch and sucrose metabolism_Homo sapiens_hsa005000.67776988
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.67771734
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66959760
106GnRH signaling pathway_Homo sapiens_hsa049120.66929460
107Focal adhesion_Homo sapiens_hsa045100.66716414
108Nucleotide excision repair_Homo sapiens_hsa034200.66158361
109Folate biosynthesis_Homo sapiens_hsa007900.65929231
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65608325
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65354156
112Glutathione metabolism_Homo sapiens_hsa004800.64549182
113Hepatitis C_Homo sapiens_hsa051600.64314562
114Bile secretion_Homo sapiens_hsa049760.64291422
115Antigen processing and presentation_Homo sapiens_hsa046120.63943233
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63556177
117Small cell lung cancer_Homo sapiens_hsa052220.62883890
118beta-Alanine metabolism_Homo sapiens_hsa004100.59889187
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59836796
120Propanoate metabolism_Homo sapiens_hsa006400.56108846
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55437996
122Tryptophan metabolism_Homo sapiens_hsa003800.54063393
123Leishmaniasis_Homo sapiens_hsa051400.53823997
124Dopaminergic synapse_Homo sapiens_hsa047280.53434398
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52960102
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52904723
127Thyroid hormone synthesis_Homo sapiens_hsa049180.52658844
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52025068
129MicroRNAs in cancer_Homo sapiens_hsa052060.50574728
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.50486727
131Complement and coagulation cascades_Homo sapiens_hsa046100.48429551
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48259915
133Shigellosis_Homo sapiens_hsa051310.48035137
134Gastric acid secretion_Homo sapiens_hsa049710.47874351
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47331018
136TNF signaling pathway_Homo sapiens_hsa046680.46934491
137Estrogen signaling pathway_Homo sapiens_hsa049150.46767030
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46597639
139Selenocompound metabolism_Homo sapiens_hsa004500.46439961
140Thyroid cancer_Homo sapiens_hsa052160.46332372
141N-Glycan biosynthesis_Homo sapiens_hsa005100.45679723
142Chemical carcinogenesis_Homo sapiens_hsa052040.45649316
143Cocaine addiction_Homo sapiens_hsa050300.45390331
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44938718
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44025155
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43732377
147Influenza A_Homo sapiens_hsa051640.43615722
148Glioma_Homo sapiens_hsa052140.43157133
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.42662044
150Toxoplasmosis_Homo sapiens_hsa051450.41507861
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41498428
152Epstein-Barr virus infection_Homo sapiens_hsa051690.41223690
153Rap1 signaling pathway_Homo sapiens_hsa040150.40732387
154Sulfur metabolism_Homo sapiens_hsa009200.40582823
155Alcoholism_Homo sapiens_hsa050340.40245006
156Choline metabolism in cancer_Homo sapiens_hsa052310.39547168
157Galactose metabolism_Homo sapiens_hsa000520.39282655
158Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38188653
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.37590712
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.36892325
161Viral carcinogenesis_Homo sapiens_hsa052030.36699089
162Arachidonic acid metabolism_Homo sapiens_hsa005900.36592478
163Metabolic pathways_Homo sapiens_hsa011000.36127313
164Amphetamine addiction_Homo sapiens_hsa050310.35495428
165Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35309704
166Measles_Homo sapiens_hsa051620.35002054
167Oocyte meiosis_Homo sapiens_hsa041140.34792882
168Tuberculosis_Homo sapiens_hsa051520.30719984
169Mineral absorption_Homo sapiens_hsa049780.29351367
170Fanconi anemia pathway_Homo sapiens_hsa034600.26104780
171Apoptosis_Homo sapiens_hsa042100.25983665
172Hematopoietic cell lineage_Homo sapiens_hsa046400.24198784
173Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21526873
174HTLV-I infection_Homo sapiens_hsa051660.19762176
175DNA replication_Homo sapiens_hsa030300.14538650
176Tyrosine metabolism_Homo sapiens_hsa003500.13046781

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