MANEAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70604661
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.40495797
3synaptic vesicle exocytosis (GO:0016079)5.32702301
4synaptic vesicle maturation (GO:0016188)5.30658917
5vocalization behavior (GO:0071625)5.20550970
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12166934
7locomotory exploration behavior (GO:0035641)4.94980780
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92997962
9neuron cell-cell adhesion (GO:0007158)4.83800089
10regulation of synaptic vesicle exocytosis (GO:2000300)4.79526182
11protein localization to synapse (GO:0035418)4.71049517
12glutamate secretion (GO:0014047)4.70999371
13neuronal action potential propagation (GO:0019227)4.55401700
14regulation of glutamate receptor signaling pathway (GO:1900449)4.55072086
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.40060959
16layer formation in cerebral cortex (GO:0021819)4.24250643
17neurotransmitter secretion (GO:0007269)4.22553633
18regulation of synaptic vesicle transport (GO:1902803)4.21798861
19exploration behavior (GO:0035640)4.20130230
20glutamate receptor signaling pathway (GO:0007215)4.14463419
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.10216034
22dendritic spine morphogenesis (GO:0060997)4.08473150
23synaptic transmission, glutamatergic (GO:0035249)4.04827496
24regulation of neuronal synaptic plasticity (GO:0048168)4.03476677
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00817125
26neuron-neuron synaptic transmission (GO:0007270)4.00276618
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.96526272
28gamma-aminobutyric acid transport (GO:0015812)3.91182851
29neuron recognition (GO:0008038)3.83463107
30regulation of synapse structural plasticity (GO:0051823)3.69086371
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68442477
32mitochondrion transport along microtubule (GO:0047497)3.68197949
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.68197949
34neurotransmitter-gated ion channel clustering (GO:0072578)3.64634133
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63715970
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.62907485
37long-term memory (GO:0007616)3.61344932
38positive regulation of membrane potential (GO:0045838)3.60569536
39proline transport (GO:0015824)3.59910797
40transmission of nerve impulse (GO:0019226)3.58694814
41establishment of mitochondrion localization (GO:0051654)3.57803260
42neurotransmitter transport (GO:0006836)3.56223479
43adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.55634743
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54955123
45positive regulation of synapse maturation (GO:0090129)3.54221447
46regulation of postsynaptic membrane potential (GO:0060078)3.49737819
47axonal fasciculation (GO:0007413)3.49018246
48synaptic vesicle endocytosis (GO:0048488)3.45661780
49cellular potassium ion homeostasis (GO:0030007)3.41176297
50pyrimidine nucleobase catabolic process (GO:0006208)3.39877476
51long-term synaptic potentiation (GO:0060291)3.39434395
52presynaptic membrane assembly (GO:0097105)3.35218175
53neuron fate specification (GO:0048665)3.35021993
54regulation of neurotransmitter secretion (GO:0046928)3.34667993
55regulation of synaptic plasticity (GO:0048167)3.33920477
56regulation of vesicle fusion (GO:0031338)3.32605805
57cerebellar Purkinje cell differentiation (GO:0021702)3.32522899
58cell migration in hindbrain (GO:0021535)3.31675411
59activation of protein kinase A activity (GO:0034199)3.29780967
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29403652
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28780486
62innervation (GO:0060384)3.28759699
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27842738
64regulation of dendritic spine morphogenesis (GO:0061001)3.26761381
65postsynaptic membrane organization (GO:0001941)3.26046947
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25845846
67body morphogenesis (GO:0010171)3.24586876
68behavioral response to nicotine (GO:0035095)3.22919771
69presynaptic membrane organization (GO:0097090)3.21562392
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.21395392
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20945739
72regulation of neurotransmitter levels (GO:0001505)3.20880020
73prepulse inhibition (GO:0060134)3.17756967
74dendrite morphogenesis (GO:0048813)3.17739450
75positive regulation of neurotransmitter transport (GO:0051590)3.17095108
76regulation of neurotransmitter transport (GO:0051588)3.14549502
77synapse assembly (GO:0007416)3.14310317
78mating behavior (GO:0007617)3.14250591
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13944495
80membrane hyperpolarization (GO:0060081)3.13737824
81behavioral response to cocaine (GO:0048148)3.12812637
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11473057
83neuromuscular process controlling balance (GO:0050885)3.11009697
84membrane depolarization (GO:0051899)3.08774399
85membrane depolarization during action potential (GO:0086010)3.08542799
86neuromuscular process controlling posture (GO:0050884)3.07892188
87cerebellar granule cell differentiation (GO:0021707)3.07274843
88sodium ion export (GO:0071436)3.06666538
89dopamine receptor signaling pathway (GO:0007212)3.05860004
90response to histamine (GO:0034776)3.05763860
91auditory behavior (GO:0031223)3.04307733
92cerebellar Purkinje cell layer development (GO:0021680)3.04111254
93learning (GO:0007612)3.00793793
94vesicle transport along microtubule (GO:0047496)3.00660875
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97982287
96behavioral fear response (GO:0001662)2.96810899
97behavioral defense response (GO:0002209)2.96810899
98positive regulation of neurotransmitter secretion (GO:0001956)2.94566381
99synaptic transmission (GO:0007268)2.94540488
100dendritic spine organization (GO:0097061)2.94037440
101adult walking behavior (GO:0007628)2.93104771
102organelle transport along microtubule (GO:0072384)2.91761523
103glycine transport (GO:0015816)2.91629869
104negative regulation of microtubule polymerization (GO:0031115)2.90868091
105neuronal ion channel clustering (GO:0045161)2.90563447
106synapse organization (GO:0050808)2.90539221
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.89442253
108regulation of glutamate secretion (GO:0014048)2.89251383
109chemosensory behavior (GO:0007635)2.89111351
110fear response (GO:0042596)2.88819246
111protein insertion into membrane (GO:0051205)2.84983328
112skeletal muscle organ development (GO:0060538)2.83818638
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76944706
114nucleobase catabolic process (GO:0046113)2.76741237
115cell-cell junction maintenance (GO:0045217)2.75170879
116regulation of respiratory system process (GO:0044065)2.74255359
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.71389458
118response to dietary excess (GO:0002021)2.63617690
119diaphragm development (GO:0060539)2.63215964
120regulation of autophagic vacuole assembly (GO:2000785)2.56302951
121positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55743965
122response to parathyroid hormone (GO:0071107)2.52417864
123substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.49231062
124substrate-independent telencephalic tangential migration (GO:0021826)2.49231062
125glandular epithelial cell differentiation (GO:0002067)2.46813044
126axon extension (GO:0048675)2.46295188
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.42923091
128protein retention in ER lumen (GO:0006621)2.41055668
129mitochondrion localization (GO:0051646)2.40246432
130regulation of translational fidelity (GO:0006450)2.37660664
131regulation of glycogen (starch) synthase activity (GO:2000465)2.37648212
132negative regulation of cell size (GO:0045792)2.35636157
133ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.34973860
134regulation of synapse maturation (GO:0090128)2.34424653
135cerebellum development (GO:0021549)2.33955255
136regulation of respiratory gaseous exchange (GO:0043576)2.32904154
137positive regulation of RNA splicing (GO:0033120)2.32050922
138dopaminergic neuron differentiation (GO:0071542)2.27187914
139ectodermal placode formation (GO:0060788)2.26512495
140protein localization to microtubule (GO:0035372)2.24943141
141regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.24404027
142peripheral nervous system neuron development (GO:0048935)2.22870479
143embryonic body morphogenesis (GO:0010172)2.18842761
144peptidyl-arginine omega-N-methylation (GO:0035247)2.18775400
145iron coordination entity transport (GO:1901678)2.17967127
146neurofilament cytoskeleton organization (GO:0060052)2.17942110
147post-embryonic morphogenesis (GO:0009886)2.17472331
148positive regulation of catecholamine secretion (GO:0033605)2.14596809
149response to misfolded protein (GO:0051788)2.13285872
150hippocampus development (GO:0021766)2.12103458
151cell junction maintenance (GO:0034331)2.11898491
152positive regulation of dendritic spine development (GO:0060999)2.10788781
153negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.10425813
154protein maturation by protein folding (GO:0022417)2.09904637
155negative regulation of organelle assembly (GO:1902116)2.08977319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18174617
2GBX2_23144817_ChIP-Seq_PC3_Human3.60761749
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39858129
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12172081
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10791122
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02960556
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.86617437
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68397669
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68397669
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66677007
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.63613423
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.57012277
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54905148
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50691535
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49521755
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48697676
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46133436
18DROSHA_22980978_ChIP-Seq_HELA_Human2.35877105
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.34959276
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26480404
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.26128041
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25382105
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.23951338
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20440863
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18003624
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.17418680
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16868445
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10176924
29TAF15_26573619_Chip-Seq_HEK293_Human2.00262675
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94950289
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89958708
32XRN2_22483619_ChIP-Seq_HELA_Human1.89206329
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87171850
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87064298
35ZNF263_19887448_ChIP-Seq_K562_Human1.85353673
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82502625
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.80305264
38AR_21572438_ChIP-Seq_LNCaP_Human1.78922924
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.77574966
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.76915931
41LXR_22292898_ChIP-Seq_THP-1_Human1.72227871
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.66362833
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65779002
44SMAD4_21799915_ChIP-Seq_A2780_Human1.64576207
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60886922
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60820833
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60532165
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58304668
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58087379
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54870796
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.50992331
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.48776005
53ZNF274_21170338_ChIP-Seq_K562_Hela1.48218838
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.47509711
55* CTCF_27219007_Chip-Seq_Bcells_Human1.45978549
56P300_19829295_ChIP-Seq_ESCs_Human1.43753651
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41841822
58* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39586224
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39033459
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38603480
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38592744
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.36939794
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36492529
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35549684
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34245308
66* CREB1_26743006_Chip-Seq_LNCaP_Human1.33842128
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.33771107
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33748156
69* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32729743
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32441421
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32105375
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.31864050
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31525869
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30272968
75* P68_20966046_ChIP-Seq_HELA_Human1.29804174
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.29669418
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29419027
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29412015
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.28941752
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28065703
81SMC4_20622854_ChIP-Seq_HELA_Human1.27952383
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27456703
83KDM5A_27292631_Chip-Seq_BREAST_Human1.26929528
84E2F7_22180533_ChIP-Seq_HELA_Human1.25425230
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23356119
86STAT3_23295773_ChIP-Seq_U87_Human1.23198197
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22943632
88RNF2_27304074_Chip-Seq_NSC_Mouse1.22477119
89AR_25329375_ChIP-Seq_VCAP_Human1.21137530
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20515751
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20153778
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.19847449
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19318063
94TTF2_22483619_ChIP-Seq_HELA_Human1.19190555
95AR_19668381_ChIP-Seq_PC3_Human1.17797579
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.17200574
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17119042
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16671842
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.16174488
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15690091
101FUS_26573619_Chip-Seq_HEK293_Human1.13437786
102IGF1R_20145208_ChIP-Seq_DFB_Human1.13358858
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13012404
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12625056
105VDR_22108803_ChIP-Seq_LS180_Human1.12516429
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.11142048
107MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11111074
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10462171
109TCF4_23295773_ChIP-Seq_U87_Human1.08889790
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08463744
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08121440
112FOXM1_23109430_ChIP-Seq_U2OS_Human1.08119543
113FOXP1_21924763_ChIP-Seq_HESCs_Human1.07510298
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07415349
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06853884
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06423447
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06011660
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.06003955
119GABP_19822575_ChIP-Seq_HepG2_Human1.05900503
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05597383
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05356705
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04919500
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.04917404
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04429997
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04426649
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04345089
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04133102
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03785893
129* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03549269
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03006262
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01824864
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.01046481
133RUNX2_22187159_ChIP-Seq_PCA_Human1.00613110
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.00361493
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.00339702
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99349440
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99174587
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99132981
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.97269904
140AHR_22903824_ChIP-Seq_MCF-7_Human0.96780946
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95421004
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95308388
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95004993
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93760487
145ER_23166858_ChIP-Seq_MCF-7_Human0.92582882
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91589641
147* KDM2B_26808549_Chip-Seq_K562_Human0.91211275
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89252474
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89252474
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89025431
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87943430
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87912833
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87612826
154JUN_21703547_ChIP-Seq_K562_Human0.87605434
155RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86687685
156BCAT_22108803_ChIP-Seq_LS180_Human0.86301826
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86197649
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.86019789
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86017991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64771614
2MP0003880_abnormal_central_pattern4.77994044
3MP0003635_abnormal_synaptic_transmissio3.94694262
4MP0004270_analgesia3.92771697
5MP0003123_paternal_imprinting3.37731397
6MP0009745_abnormal_behavioral_response3.24528519
7MP0002063_abnormal_learning/memory/cond3.13718948
8MP0009046_muscle_twitch3.05754690
9MP0001968_abnormal_touch/_nociception3.05521531
10MP0002064_seizures3.05347935
11MP0005423_abnormal_somatic_nervous2.90478066
12MP0002734_abnormal_mechanical_nocicepti2.80265794
13MP0002572_abnormal_emotion/affect_behav2.71606243
14MP0002272_abnormal_nervous_system2.65550759
15MP0002822_catalepsy2.51347701
16MP0001486_abnormal_startle_reflex2.47987044
17MP0002736_abnormal_nociception_after2.43151916
18MP0002735_abnormal_chemical_nociception2.32889115
19MP0002733_abnormal_thermal_nociception2.14150434
20MP0001440_abnormal_grooming_behavior2.11703368
21MP0010234_abnormal_vibrissa_follicle2.10341884
22MP0001970_abnormal_pain_threshold2.04311264
23MP0000778_abnormal_nervous_system2.03779281
24MP0002067_abnormal_sensory_capabilities2.01720523
25MP0006276_abnormal_autonomic_nervous2.00363638
26MP0001501_abnormal_sleep_pattern1.99848730
27MP0002184_abnormal_innervation1.97420970
28MP0000566_synostosis1.93839794
29MP0000537_abnormal_urethra_morphology1.89980797
30MP0003329_amyloid_beta_deposits1.83082012
31MP0001984_abnormal_olfaction1.81576412
32MP0002909_abnormal_adrenal_gland1.79954382
33MP0008569_lethality_at_weaning1.78440529
34MP0005386_behavior/neurological_phenoty1.76836229
35MP0004924_abnormal_behavior1.76836229
36MP0001529_abnormal_vocalization1.75773076
37MP0009780_abnormal_chondrocyte_physiolo1.73689914
38MP0004811_abnormal_neuron_physiology1.73671599
39MP0002557_abnormal_social/conspecific_i1.72232249
40MP0005645_abnormal_hypothalamus_physiol1.68180387
41MP0000955_abnormal_spinal_cord1.67029270
42MP0005551_abnormal_eye_electrophysiolog1.61741111
43MP0003787_abnormal_imprinting1.61102499
44MP0004858_abnormal_nervous_system1.59641190
45MP0002882_abnormal_neuron_morphology1.56070525
46MP0005646_abnormal_pituitary_gland1.46948281
47MP0003122_maternal_imprinting1.45781939
48MP0002066_abnormal_motor_capabilities/c1.45626301
49MP0001905_abnormal_dopamine_level1.45416985
50MP0001944_abnormal_pancreas_morphology1.44485917
51MP0002163_abnormal_gland_morphology1.44475097
52MP0004885_abnormal_endolymph1.41928226
53MP0003942_abnormal_urinary_system1.39974563
54MP0004142_abnormal_muscle_tone1.38794880
55MP0000538_abnormal_urinary_bladder1.38678790
56MP0002160_abnormal_reproductive_system1.36441228
57MP0006072_abnormal_retinal_apoptosis1.33178582
58MP0003315_abnormal_perineum_morphology1.30351689
59MP0001502_abnormal_circadian_rhythm1.29557841
60MP0001346_abnormal_lacrimal_gland1.29112390
61MP0002229_neurodegeneration1.25162788
62MP0003879_abnormal_hair_cell1.20882784
63MP0003633_abnormal_nervous_system1.19055805
64MP0002152_abnormal_brain_morphology1.18324504
65MP0005379_endocrine/exocrine_gland_phen1.17433446
66MP0001188_hyperpigmentation1.13508182
67MP0004742_abnormal_vestibular_system1.13267190
68MP0002249_abnormal_larynx_morphology1.10568354
69MP0000534_abnormal_ureter_morphology1.07809441
70MP0003631_nervous_system_phenotype1.06421396
71MP0003693_abnormal_embryo_hatching1.05542375
72MP0000462_abnormal_digestive_system1.04731014
73MP0000631_abnormal_neuroendocrine_gland1.03390219
74MP0003634_abnormal_glial_cell1.01732696
75MP0005394_taste/olfaction_phenotype1.01426885
76MP0005499_abnormal_olfactory_system1.01426885
77MP0004145_abnormal_muscle_electrophysio1.01379418
78MP0002752_abnormal_somatic_nervous1.00032595
79MP0010386_abnormal_urinary_bladder0.99742749
80MP0000013_abnormal_adipose_tissue0.97918889
81MP0005623_abnormal_meninges_morphology0.96349668
82MP0002069_abnormal_eating/drinking_beha0.93315194
83MP0004133_heterotaxia0.92933913
84MP0005253_abnormal_eye_physiology0.91230155
85MP0003890_abnormal_embryonic-extraembry0.90675936
86MP0000920_abnormal_myelination0.90489698
87MP0005220_abnormal_exocrine_pancreas0.88336861
88MP0002638_abnormal_pupillary_reflex0.88002058
89MP0001963_abnormal_hearing_physiology0.87213486
90MP0002876_abnormal_thyroid_physiology0.86826216
91MP0003632_abnormal_nervous_system0.86512985
92MP0003283_abnormal_digestive_organ0.85960775
93MP0002837_dystrophic_cardiac_calcinosis0.85883635
94MP0009672_abnormal_birth_weight0.85575381
95MP0000003_abnormal_adipose_tissue0.84903385
96MP0002090_abnormal_vision0.84559200
97MP0008872_abnormal_physiological_respon0.82861206
98MP0005409_darkened_coat_color0.81053636
99MP0000751_myopathy0.80680019
100MP0001348_abnormal_lacrimal_gland0.78722796
101MP0004085_abnormal_heartbeat0.77673315
102MP0000569_abnormal_digit_pigmentation0.76812761
103MP0002081_perinatal_lethality0.76296728
104MP0002234_abnormal_pharynx_morphology0.75224509
105MP0005535_abnormal_body_temperature0.74939413
106MP0000678_abnormal_parathyroid_gland0.74515210
107MP0002697_abnormal_eye_size0.74509838
108MP0004043_abnormal_pH_regulation0.74147821
109MP0008874_decreased_physiological_sensi0.73673058
110MP0002928_abnormal_bile_duct0.73391166
111MP0003868_abnormal_feces_composition0.72782323
112MP0001485_abnormal_pinna_reflex0.71933661
113MP0001177_atelectasis0.70883538
114MP0004185_abnormal_adipocyte_glucose0.70559477
115MP0002693_abnormal_pancreas_physiology0.70270353
116MP0009379_abnormal_foot_pigmentation0.70166528
117MP0001299_abnormal_eye_distance/0.70085485
118MP0000604_amyloidosis0.69343209
119MP0003937_abnormal_limbs/digits/tail_de0.68026344
120MP0003861_abnormal_nervous_system0.67983828
121MP0000681_abnormal_thyroid_gland0.67577463
122MP0004233_abnormal_muscle_weight0.66862373
123MP0001919_abnormal_reproductive_system0.66553152
124MP0010770_preweaning_lethality0.66378433
125MP0003690_abnormal_glial_cell0.64250969
126MP0005195_abnormal_posterior_eye0.60879667
127MP0001943_abnormal_respiration0.59826826
128MP0002653_abnormal_ependyma_morphology0.59646397
129MP0005187_abnormal_penis_morphology0.59389160
130MP0003121_genomic_imprinting0.59232355
131MP0001664_abnormal_digestion0.58485315
132MP0000026_abnormal_inner_ear0.58368934
133MP0002751_abnormal_autonomic_nervous0.58134390
134MP0004215_abnormal_myocardial_fiber0.57511231
135MP0001986_abnormal_taste_sensitivity0.57270590
136MP0008961_abnormal_basal_metabolism0.55638849
137MP0003137_abnormal_impulse_conducting0.55580001

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.88192534
2Myokymia (HP:0002411)6.35103208
3Focal seizures (HP:0007359)5.39479651
4Visual hallucinations (HP:0002367)5.16552228
5Atonic seizures (HP:0010819)4.67223338
6Epileptic encephalopathy (HP:0200134)4.50863347
7Febrile seizures (HP:0002373)4.16058725
8Progressive cerebellar ataxia (HP:0002073)4.16023138
9Absence seizures (HP:0002121)4.06277654
10Action tremor (HP:0002345)3.80292926
11Dialeptic seizures (HP:0011146)3.72886851
12Supranuclear gaze palsy (HP:0000605)3.65179173
13Generalized tonic-clonic seizures (HP:0002069)3.53584561
14Ankle clonus (HP:0011448)3.33425675
15Double outlet right ventricle (HP:0001719)3.32527480
16Congenital malformation of the right heart (HP:0011723)3.32527480
17Septate vagina (HP:0001153)3.28470812
18Broad-based gait (HP:0002136)3.28086867
19Hyperthyroidism (HP:0000836)3.21140919
20Hyperventilation (HP:0002883)3.15840206
21Poor eye contact (HP:0000817)3.14321912
22Truncal ataxia (HP:0002078)3.11210368
23Impaired vibration sensation in the lower limbs (HP:0002166)3.02027448
24Cerebral inclusion bodies (HP:0100314)3.00641413
25Gaze-evoked nystagmus (HP:0000640)2.99746673
26Dysdiadochokinesis (HP:0002075)2.99570908
27Anxiety (HP:0000739)2.96874699
28Amblyopia (HP:0000646)2.96223022
29Depression (HP:0000716)2.95119864
30Neurofibrillary tangles (HP:0002185)2.92271793
31Abnormality of the corticospinal tract (HP:0002492)2.91110199
32Dysmetria (HP:0001310)2.90888050
33Urinary bladder sphincter dysfunction (HP:0002839)2.83603390
34Limb dystonia (HP:0002451)2.82296788
35Impaired social interactions (HP:0000735)2.80983201
36Abnormal social behavior (HP:0012433)2.80983201
37Pheochromocytoma (HP:0002666)2.78705557
38Hemiparesis (HP:0001269)2.77037303
39Insidious onset (HP:0003587)2.76002183
40Termporal pattern (HP:0011008)2.76002183
41Mutism (HP:0002300)2.72308840
42Hyperparathyroidism (HP:0000843)2.71394097
43Drooling (HP:0002307)2.71351135
44Excessive salivation (HP:0003781)2.71351135
45Truncus arteriosus (HP:0001660)2.68901520
46Spastic gait (HP:0002064)2.68449894
47Hypercortisolism (HP:0001578)2.65415088
48Abnormal eating behavior (HP:0100738)2.64759104
49Genetic anticipation (HP:0003743)2.62702845
50Epileptiform EEG discharges (HP:0011182)2.61621837
51Progressive inability to walk (HP:0002505)2.59672899
52Urinary urgency (HP:0000012)2.55892422
53EEG with generalized epileptiform discharges (HP:0011198)2.54045724
54Scanning speech (HP:0002168)2.53239527
55Abnormality of binocular vision (HP:0011514)2.52566577
56Diplopia (HP:0000651)2.52566577
57Akinesia (HP:0002304)2.51328198
58Impaired smooth pursuit (HP:0007772)2.47888519
59Neuroendocrine neoplasm (HP:0100634)2.46640145
60Asymmetry of the thorax (HP:0001555)2.44617458
61Hypsarrhythmia (HP:0002521)2.43620277
62Macroorchidism (HP:0000053)2.41632356
63Enlarged penis (HP:0000040)2.40221467
64Shawl scrotum (HP:0000049)2.39427363
65Abnormality of the lower motor neuron (HP:0002366)2.37529082
66Postural instability (HP:0002172)2.32685582
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.31015961
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31015961
69Megalencephaly (HP:0001355)2.28851101
70Abnormal ventriculo-arterial connection (HP:0011563)2.28813334
71Transposition of the great arteries (HP:0001669)2.28813334
72Abnormal connection of the cardiac segments (HP:0011545)2.28813334
73Intention tremor (HP:0002080)2.26727716
74Abnormal pancreas size (HP:0012094)2.25546049
75Gait imbalance (HP:0002141)2.22023822
76Torticollis (HP:0000473)2.21452568
77Bradykinesia (HP:0002067)2.21080659
78Agitation (HP:0000713)2.20765813
79Papilledema (HP:0001085)2.19952654
80Hyperphosphatemia (HP:0002905)2.18915196
81Polyphagia (HP:0002591)2.16161383
82Lower limb muscle weakness (HP:0007340)2.14919919
83Amyotrophic lateral sclerosis (HP:0007354)2.14905796
84Hyperacusis (HP:0010780)2.13782475
85Abnormality of ocular smooth pursuit (HP:0000617)2.10005070
86Broad distal phalanx of finger (HP:0009836)2.09527001
87Absent speech (HP:0001344)2.09326319
88Stereotypic behavior (HP:0000733)2.09135930
89Focal dystonia (HP:0004373)2.07411275
90Poor suck (HP:0002033)2.07228704
91Central scotoma (HP:0000603)2.03100587
92Down-sloping shoulders (HP:0200021)2.02309204
93Failure to thrive in infancy (HP:0001531)2.02071766
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.01025148
95Abnormality of the aortic arch (HP:0012303)2.00203875
96Growth hormone excess (HP:0000845)1.99371907
97Generalized myoclonic seizures (HP:0002123)1.98996267
98Specific learning disability (HP:0001328)1.98915207
99Lissencephaly (HP:0001339)1.98861060
100Delusions (HP:0000746)1.97898125
101Psychosis (HP:0000709)1.97739979
102Impaired vibratory sensation (HP:0002495)1.97295531
103Diminished movement (HP:0002374)1.96771054
104Neuronal loss in central nervous system (HP:0002529)1.96705610
105Retinal dysplasia (HP:0007973)1.96538870
106Inability to walk (HP:0002540)1.95227867
107Hyperinsulinemic hypoglycemia (HP:0000825)1.93728711
108Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91024079
109Fetal akinesia sequence (HP:0001989)1.90714816
110Abnormality of macular pigmentation (HP:0008002)1.90613512
111Deep venous thrombosis (HP:0002625)1.90584530
112Sparse lateral eyebrow (HP:0005338)1.90388095
113Deep palmar crease (HP:0006191)1.89845592
114Hemiplegia (HP:0002301)1.89710223
115Testicular neoplasm (HP:0010788)1.89109980
116Muscular hypotonia of the trunk (HP:0008936)1.89075759
117Testicular atrophy (HP:0000029)1.89054795
118Craniofacial dystonia (HP:0012179)1.86590212
119Status epilepticus (HP:0002133)1.86409105
120Clonus (HP:0002169)1.85704989
121Congenital stationary night blindness (HP:0007642)1.84660076
122Ventricular fibrillation (HP:0001663)1.84311157
123Type II lissencephaly (HP:0007260)1.84237231
124Morphological abnormality of the pyramidal tract (HP:0002062)1.83639412
125Hypoventilation (HP:0002791)1.82739372
126Gait ataxia (HP:0002066)1.81850100
127Abnormality of salivation (HP:0100755)1.81566648
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80448640
129Postural tremor (HP:0002174)1.80253052
130Hypokinesia (HP:0002375)1.79244438
131Dysmetric saccades (HP:0000641)1.78479606
132Hypoplasia of the brainstem (HP:0002365)1.78071298
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78071298
134Germ cell neoplasia (HP:0100728)1.77852850
135Insomnia (HP:0100785)1.77486635
136Incomplete penetrance (HP:0003829)1.76571378
137Congenital primary aphakia (HP:0007707)1.75772076
138Neoplasm of the peripheral nervous system (HP:0100007)1.73164560
139Midline defect of the nose (HP:0004122)1.71649291
140Self-mutilation (HP:0000742)1.70656760
141Hepatoblastoma (HP:0002884)1.69588965
142Neoplasm of the adrenal cortex (HP:0100641)1.68862850
143Ketoacidosis (HP:0001993)1.68777262
144Exotropia (HP:0000577)1.68525879
145Concave nail (HP:0001598)1.68362046
146Elfin facies (HP:0004428)1.66207221
147Optic nerve coloboma (HP:0000588)1.65093030
148Spastic tetraplegia (HP:0002510)1.63092974
149Microretrognathia (HP:0000308)1.61788768
150High anterior hairline (HP:0009890)1.61336489
151Polymicrogyria (HP:0002126)1.60953814
152Urethral obstruction (HP:0000796)1.59132093
153Cerebral hypomyelination (HP:0006808)1.58742809
154Restlessness (HP:0000711)1.57833277
155Abnormality of the Achilles tendon (HP:0005109)1.57385455
156Achilles tendon contracture (HP:0001771)1.56173537
157Bifid scrotum (HP:0000048)1.55554669
158CNS hypomyelination (HP:0003429)1.53953275
159Neonatal hypoglycemia (HP:0001998)1.53667432
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.52635102
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.52635102
162Horseshoe kidney (HP:0000085)1.51406709
163Menstrual irregularities (HP:0000858)1.51329160
164Preauricular skin tag (HP:0000384)1.51076209
165Heterotopia (HP:0002282)1.50124973
166Unilateral renal agenesis (HP:0000122)1.48677100
167Open mouth (HP:0000194)1.48550304
168Late onset (HP:0003584)1.48358674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.16402094
2NTRK34.15778005
3EPHA43.72243983
4MAP3K93.69086595
5MARK13.61639920
6MAP3K43.13550731
7ICK2.92069376
8IRAK32.75178122
9MINK12.75097780
10MAP2K72.50386135
11EEF2K2.32698294
12PAK62.21859407
13CASK2.15593506
14PNCK2.11687177
15KSR22.11145910
16MAP3K122.06884583
17DAPK22.02774877
18NTRK21.99918871
19NTRK11.99040155
20MAP2K41.90871888
21RIPK41.89811217
22NME21.85209208
23KSR11.66727709
24GRK51.66410863
25TNIK1.55774258
26CDK51.55669516
27SMG11.55607026
28PRKD31.52741829
29UHMK11.51040150
30PLK21.49440075
31MAPK131.49424373
32CAMK1D1.46869857
33CAMKK11.45135701
34ARAF1.42710012
35PRKCI1.41016132
36CDK191.40928969
37MAP3K21.37760859
38SIK11.37320120
39DAPK11.30701744
40SIK21.29647226
41PRPF4B1.28784561
42IRAK21.25380397
43PRKCG1.18466606
44PHKG21.17165934
45PHKG11.17165934
46PKN21.15907204
47BRAF1.12038740
48CAMK2A1.04968610
49EPHB21.04097869
50CAMKK21.02769717
51OXSR11.02072527
52CDK81.00672710
53TYRO31.00599045
54SGK2231.00568217
55SGK4941.00568217
56CAMK2B0.97679853
57CDK180.97145647
58FES0.96158282
59CSNK1A1L0.95905206
60CDK140.95869727
61CDK150.95715970
62EPHA20.95687288
63CSNK1G10.95524274
64STK380.93372086
65PAK30.92233737
66DYRK1A0.92106295
67CSNK1G20.90032964
68AURKA0.88711888
69STK110.86369224
70RET0.84976473
71CDK11A0.83883074
72PIM20.83413925
73RPS6KA20.82736404
74MTOR0.82111657
75DYRK30.80095054
76BMPR20.79712906
77LATS20.78920207
78GRK70.78158070
79MST1R0.76349513
80STK160.75906623
81ILK0.75022180
82PRKCH0.73786034
83NME10.73295686
84STK390.72780008
85AKT20.71927952
86BRSK10.70625698
87WNK30.70044525
88CHEK20.69666628
89MARK20.69263482
90RAF10.68966915
91FGR0.68760745
92CSNK1E0.67522495
93MAP3K130.66522745
94CDK120.65863086
95PRKAA10.65296236
96CAMK10.64815780
97MAP3K110.64572850
98CDK30.64343349
99BCR0.63287971
100WNK10.63121220
101PTK2B0.63007350
102CAMK2D0.62705840
103CDK70.62594279
104PINK10.62437318
105SGK10.59704788
106MAP2K20.59101847
107RPS6KB20.58007196
108SGK20.57870989
109TESK10.57867209
110PRKCE0.55882245
111TLK10.53732811
112TAOK10.53558576
113TNK20.52318587
114DYRK20.51237615
115CAMK2G0.51152628
116LIMK10.51098196
117CAMK1G0.50291124
118ALK0.50276885
119PTK20.49807056
120PRKCZ0.49276687
121MAP3K10.49011672
122CSNK1G30.48106756
123ROCK20.46992447
124RPS6KB10.46832500
125ADRBK10.46731222
126RPS6KA30.46476710
127MAPK100.45468382
128PDPK10.45328486
129FYN0.44622321
130FGFR20.44620701
131MAP3K60.44107083
132WNK40.43234599
133PKN10.42760496
134SGK30.42416741
135MAPKAPK50.41976841
136EIF2AK10.40349829
137PDK10.40204459
138MAP2K10.40125813
139BUB10.39930702
140SCYL20.39761412
141CDK10.39349723
142CCNB10.36918993
143FER0.36892642
144LMTK20.36522104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76904847
2Synaptic vesicle cycle_Homo sapiens_hsa047213.37012198
3GABAergic synapse_Homo sapiens_hsa047272.79744162
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73477327
5Olfactory transduction_Homo sapiens_hsa047402.72873668
6Circadian entrainment_Homo sapiens_hsa047132.64623778
7Sulfur relay system_Homo sapiens_hsa041222.63909141
8Long-term potentiation_Homo sapiens_hsa047202.61311409
9Glutamatergic synapse_Homo sapiens_hsa047242.58988647
10Morphine addiction_Homo sapiens_hsa050322.53475093
11Amphetamine addiction_Homo sapiens_hsa050312.44004013
12Vitamin B6 metabolism_Homo sapiens_hsa007502.33499245
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.31129860
14Dopaminergic synapse_Homo sapiens_hsa047282.30242150
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19892886
16Phototransduction_Homo sapiens_hsa047442.06273131
17Salivary secretion_Homo sapiens_hsa049702.04809337
18Insulin secretion_Homo sapiens_hsa049112.03574648
19Cholinergic synapse_Homo sapiens_hsa047251.90799392
20Taste transduction_Homo sapiens_hsa047421.88609831
21Serotonergic synapse_Homo sapiens_hsa047261.81247562
22Long-term depression_Homo sapiens_hsa047301.79764143
23Gastric acid secretion_Homo sapiens_hsa049711.79647321
24Collecting duct acid secretion_Homo sapiens_hsa049661.78748644
25Cocaine addiction_Homo sapiens_hsa050301.73801878
26Renin secretion_Homo sapiens_hsa049241.72998630
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68151966
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64407204
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59395165
30Oxytocin signaling pathway_Homo sapiens_hsa049211.56084203
31Calcium signaling pathway_Homo sapiens_hsa040201.47411367
32GnRH signaling pathway_Homo sapiens_hsa049121.41720616
33Gap junction_Homo sapiens_hsa045401.36066165
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28536800
35Folate biosynthesis_Homo sapiens_hsa007901.26738710
36Vibrio cholerae infection_Homo sapiens_hsa051101.23515755
37Axon guidance_Homo sapiens_hsa043601.22203483
38Steroid biosynthesis_Homo sapiens_hsa001001.21786508
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21172831
40Cardiac muscle contraction_Homo sapiens_hsa042601.20265508
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19364048
42cAMP signaling pathway_Homo sapiens_hsa040241.17290578
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14626340
44Type II diabetes mellitus_Homo sapiens_hsa049301.12781324
45Estrogen signaling pathway_Homo sapiens_hsa049151.12644023
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10773692
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08074142
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07027482
49Fatty acid biosynthesis_Homo sapiens_hsa000611.03196361
50Melanogenesis_Homo sapiens_hsa049161.02117107
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01569237
52Glioma_Homo sapiens_hsa052141.01131319
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00060969
54AMPK signaling pathway_Homo sapiens_hsa041520.99805769
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99170224
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97984781
57ErbB signaling pathway_Homo sapiens_hsa040120.94536191
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.94476631
59Alzheimers disease_Homo sapiens_hsa050100.93659632
60N-Glycan biosynthesis_Homo sapiens_hsa005100.93245310
61Oxidative phosphorylation_Homo sapiens_hsa001900.91932937
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.89803367
63Oocyte meiosis_Homo sapiens_hsa041140.89276376
64Biosynthesis of amino acids_Homo sapiens_hsa012300.87874068
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86050293
66Pancreatic secretion_Homo sapiens_hsa049720.84992493
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79725796
68Dorso-ventral axis formation_Homo sapiens_hsa043200.76008043
69Parkinsons disease_Homo sapiens_hsa050120.75549313
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.74274277
71Ribosome_Homo sapiens_hsa030100.74253202
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.73363815
73Lysine degradation_Homo sapiens_hsa003100.72482089
74Thyroid hormone synthesis_Homo sapiens_hsa049180.72034856
75mRNA surveillance pathway_Homo sapiens_hsa030150.71711304
76Phenylalanine metabolism_Homo sapiens_hsa003600.70327489
77Arginine biosynthesis_Homo sapiens_hsa002200.69401975
78Alcoholism_Homo sapiens_hsa050340.68333077
79MAPK signaling pathway_Homo sapiens_hsa040100.67747948
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67313776
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66806133
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66408476
83Arginine and proline metabolism_Homo sapiens_hsa003300.64983747
84Fructose and mannose metabolism_Homo sapiens_hsa000510.64547776
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64090176
86Choline metabolism in cancer_Homo sapiens_hsa052310.62599475
87Dilated cardiomyopathy_Homo sapiens_hsa054140.60612878
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58589522
89VEGF signaling pathway_Homo sapiens_hsa043700.58080746
90Fatty acid metabolism_Homo sapiens_hsa012120.57978724
91Ras signaling pathway_Homo sapiens_hsa040140.57572279
92Glucagon signaling pathway_Homo sapiens_hsa049220.56990262
93Pyrimidine metabolism_Homo sapiens_hsa002400.56878270
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56293641
95Type I diabetes mellitus_Homo sapiens_hsa049400.54076011
96Base excision repair_Homo sapiens_hsa034100.54075040
97DNA replication_Homo sapiens_hsa030300.53644091
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53345972
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.53222593
100Notch signaling pathway_Homo sapiens_hsa043300.52822740
101Sphingolipid metabolism_Homo sapiens_hsa006000.51610684
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51276808
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51189257
104Hippo signaling pathway_Homo sapiens_hsa043900.50947582
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.50599287
106Selenocompound metabolism_Homo sapiens_hsa004500.50589393
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49176436
108RNA polymerase_Homo sapiens_hsa030200.48296543
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48161765
110Renal cell carcinoma_Homo sapiens_hsa052110.47797016
111Chronic myeloid leukemia_Homo sapiens_hsa052200.47753441
112Rap1 signaling pathway_Homo sapiens_hsa040150.46027287
113Inositol phosphate metabolism_Homo sapiens_hsa005620.45948689
114Bladder cancer_Homo sapiens_hsa052190.45851848
115Huntingtons disease_Homo sapiens_hsa050160.44536344
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43632098
117Wnt signaling pathway_Homo sapiens_hsa043100.42714467
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41879192
119Prion diseases_Homo sapiens_hsa050200.41633375
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41523729
121Endocytosis_Homo sapiens_hsa041440.41185532
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40061160
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39958534
124mTOR signaling pathway_Homo sapiens_hsa041500.38470953
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38455489
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36650087
127Endometrial cancer_Homo sapiens_hsa052130.36143420
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35578284
129Non-small cell lung cancer_Homo sapiens_hsa052230.33589838
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33336946
131Insulin signaling pathway_Homo sapiens_hsa049100.33030133
132Circadian rhythm_Homo sapiens_hsa047100.31797943
133Bile secretion_Homo sapiens_hsa049760.30925674
134Ovarian steroidogenesis_Homo sapiens_hsa049130.29860619
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26863771
136Butanoate metabolism_Homo sapiens_hsa006500.26729922
137African trypanosomiasis_Homo sapiens_hsa051430.26401227
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26206605

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