MAN1C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89433264
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89433264
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.89433264
4modulation by symbiont of host immune response (GO:0052553)4.89433264
5positive regulation by symbiont of host defense response (GO:0052509)4.89433264
6modulation by symbiont of host defense response (GO:0052031)4.89433264
7central nervous system myelination (GO:0022010)4.30186470
8axon ensheathment in central nervous system (GO:0032291)4.30186470
9response to pheromone (GO:0019236)4.14874596
10microglial cell activation (GO:0001774)4.08847213
11regulation of interferon-beta biosynthetic process (GO:0045357)4.05075052
12macrophage activation involved in immune response (GO:0002281)4.04034421
13estrogen biosynthetic process (GO:0006703)3.79998095
14behavioral response to nicotine (GO:0035095)3.59180540
15response to host immune response (GO:0052572)3.57704789
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57704789
17gamma-aminobutyric acid transport (GO:0015812)3.55420351
18mannose metabolic process (GO:0006013)3.52744894
19neuronal action potential propagation (GO:0019227)3.38253110
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37801070
21response to host (GO:0075136)3.37801070
22response to host defenses (GO:0052200)3.37801070
23dendritic spine morphogenesis (GO:0060997)3.30811783
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17246440
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.16479654
26postsynaptic membrane organization (GO:0001941)3.11086857
27macrophage activation (GO:0042116)3.09983719
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.08119090
29membrane depolarization during action potential (GO:0086010)3.07372029
30apoptotic cell clearance (GO:0043277)2.99400091
31proline transport (GO:0015824)2.91460233
32neuromuscular process controlling posture (GO:0050884)2.85979857
33neutrophil activation involved in immune response (GO:0002283)2.82877557
34negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82624654
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82395711
36synaptic vesicle maturation (GO:0016188)2.79416806
37prostate gland growth (GO:0060736)2.77982902
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77321103
39transmission of nerve impulse (GO:0019226)2.76992634
40regulation of neurotransmitter uptake (GO:0051580)2.76791459
41presynaptic membrane assembly (GO:0097105)2.74655335
42auditory behavior (GO:0031223)2.73045524
43L-amino acid import (GO:0043092)2.72538857
44serotonin metabolic process (GO:0042428)2.71926421
45presynaptic membrane organization (GO:0097090)2.71157358
46urinary tract smooth muscle contraction (GO:0014848)2.68481574
47primary amino compound metabolic process (GO:1901160)2.66028225
48regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64111981
49regulation of synapse structural plasticity (GO:0051823)2.62272403
50ionotropic glutamate receptor signaling pathway (GO:0035235)2.61651937
51startle response (GO:0001964)2.60690795
52glutamate receptor signaling pathway (GO:0007215)2.59905067
53positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.59493516
54negative regulation of granulocyte differentiation (GO:0030853)2.58044319
55cyclic nucleotide catabolic process (GO:0009214)2.56600931
56I-kappaB phosphorylation (GO:0007252)2.54524361
57regulation of respiratory system process (GO:0044065)2.53091443
58amino acid import (GO:0043090)2.53003343
59adaptation of signaling pathway (GO:0023058)2.51741412
60neuronal action potential (GO:0019228)2.51558680
61regulation of calcium ion-dependent exocytosis (GO:0017158)2.51552540
62alanine transport (GO:0032328)2.49666306
63regulation of macrophage chemotaxis (GO:0010758)2.44765511
64vocalization behavior (GO:0071625)2.44198959
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43862056
66keratan sulfate catabolic process (GO:0042340)2.43669239
67response to peptidoglycan (GO:0032494)2.43627753
68synaptic transmission, glutamatergic (GO:0035249)2.43499245
69positive regulation of cellular amide metabolic process (GO:0034250)2.42760480
70cortical actin cytoskeleton organization (GO:0030866)2.42549066
71potassium ion transmembrane transport (GO:0071805)2.41688240
72cellular potassium ion transport (GO:0071804)2.41688240
73cAMP catabolic process (GO:0006198)2.41681253
74neurotransmitter secretion (GO:0007269)2.41356209
75potassium ion import (GO:0010107)2.41059796
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40792919
77relaxation of cardiac muscle (GO:0055119)2.39422864
78negative regulation of hormone biosynthetic process (GO:0032353)2.39277642
79adhesion of symbiont to host cell (GO:0044650)2.38393832
80virion attachment to host cell (GO:0019062)2.38393832
81negative regulation of protein oligomerization (GO:0032460)2.36955135
82protein localization to cilium (GO:0061512)2.35614830
83cell adhesion mediated by integrin (GO:0033627)2.35326638
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34335717
85myeloid cell activation involved in immune response (GO:0002275)2.34266159
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34227398
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33482791
88positive regulation of oligodendrocyte differentiation (GO:0048714)2.32283640
89semaphorin-plexin signaling pathway (GO:0071526)2.31742108
90positive regulation of interferon-alpha production (GO:0032727)2.31693111
91potassium ion transport (GO:0006813)2.31517764
92neuron cell-cell adhesion (GO:0007158)2.30930402
93regulation of mononuclear cell migration (GO:0071675)2.30485177
94nephron tubule morphogenesis (GO:0072078)2.29239174
95nephron epithelium morphogenesis (GO:0072088)2.29239174
96positive regulation of antigen processing and presentation (GO:0002579)2.28114103
97neuron-neuron synaptic transmission (GO:0007270)2.27384525
98regulation of respiratory gaseous exchange (GO:0043576)2.27306864
99thyroid hormone metabolic process (GO:0042403)2.27086794
100membrane depolarization (GO:0051899)2.26942353
101detection of calcium ion (GO:0005513)2.26527191
102indole-containing compound metabolic process (GO:0042430)2.25297729
103neuromuscular synaptic transmission (GO:0007274)2.24810206
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.24562235
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.23890889
106negative regulation of cell killing (GO:0031342)2.23890889
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23768149
108auditory receptor cell stereocilium organization (GO:0060088)2.23563032
109action potential (GO:0001508)2.23088599
110cortical cytoskeleton organization (GO:0030865)2.22122689
111response to lipoprotein particle (GO:0055094)2.21699154
112reflex (GO:0060004)2.21546584
113negative regulation of activin receptor signaling pathway (GO:0032926)2.21435218
114catecholamine transport (GO:0051937)2.21031500
115kidney morphogenesis (GO:0060993)2.19437648
116regulation of B cell receptor signaling pathway (GO:0050855)2.19197683
117gamma-aminobutyric acid signaling pathway (GO:0007214)2.19193346
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.19058473
119cochlea development (GO:0090102)2.18409772
120regulation of ARF protein signal transduction (GO:0032012)2.17361447
121substrate-dependent cell migration (GO:0006929)2.17250969
122glycosphingolipid biosynthetic process (GO:0006688)2.17159832
123sodium ion export (GO:0071436)2.16928525
124indolalkylamine catabolic process (GO:0046218)2.16864861
125tryptophan catabolic process (GO:0006569)2.16864861
126indole-containing compound catabolic process (GO:0042436)2.16864861
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.16767717
128glutamate secretion (GO:0014047)2.16644496
129parturition (GO:0007567)2.16469278
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16331800
131glycerophospholipid catabolic process (GO:0046475)2.15674180
132relaxation of smooth muscle (GO:0044557)2.15564436
133negative regulation of astrocyte differentiation (GO:0048712)2.15391118
134regulation of action potential (GO:0098900)2.15202751
135indolalkylamine metabolic process (GO:0006586)2.15079159
136L-fucose catabolic process (GO:0042355)2.14930995
137fucose catabolic process (GO:0019317)2.14930995
138L-fucose metabolic process (GO:0042354)2.14930995
139regulation of interferon-alpha production (GO:0032647)2.14741126
140regulation of chemokine-mediated signaling pathway (GO:0070099)2.14733608
141neurotransmitter-gated ion channel clustering (GO:0072578)2.14421873
142synaptic vesicle exocytosis (GO:0016079)2.14152826
143cellular ketone body metabolic process (GO:0046950)2.14027364
144regulation of voltage-gated calcium channel activity (GO:1901385)2.13887991
145pyrimidine nucleobase catabolic process (GO:0006208)2.13424592
146phagocytosis, engulfment (GO:0006911)2.13245780
147protein localization to synapse (GO:0035418)2.12464502
148respiratory burst (GO:0045730)2.12082296
149regulation of mast cell degranulation (GO:0043304)2.11622586
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.10704169
151regulation of regulated secretory pathway (GO:1903305)2.10159754
152regulation of leukocyte degranulation (GO:0043300)2.08993935
153cellular extravasation (GO:0045123)2.08142702
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.07941165
155positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.07902635
156response to fluid shear stress (GO:0034405)2.07198335
157phagosome maturation (GO:0090382)2.07197412
158monocyte chemotaxis (GO:0002548)2.07004769
159response to muramyl dipeptide (GO:0032495)2.06783237
160G-protein coupled receptor internalization (GO:0002031)2.06407262
161activated T cell proliferation (GO:0050798)2.06052843
162protein localization to endosome (GO:0036010)2.05575900
163hyaluronan catabolic process (GO:0030214)2.05466377
164positive regulation of leukocyte degranulation (GO:0043302)2.04675501
165cellular potassium ion homeostasis (GO:0030007)2.03599257
166adhesion of symbiont to host (GO:0044406)2.03551467
167regulation of mast cell activation involved in immune response (GO:0033006)2.02538779
168granulocyte activation (GO:0036230)2.02043598
169regulation of ARF GTPase activity (GO:0032312)2.01969627
170nerve growth factor signaling pathway (GO:0038180)2.00588572
171ruffle organization (GO:0031529)2.00139543
172lysosome organization (GO:0007040)2.00122449
173lytic vacuole organization (GO:0080171)2.00122449
174positive regulation of interferon-gamma biosynthetic process (GO:0045078)1.99035870
175neutrophil activation (GO:0042119)1.97266090
176potassium ion homeostasis (GO:0055075)1.97125258
177positive regulation of mast cell activation (GO:0033005)1.96325228
178positive regulation of heat generation (GO:0031652)1.96242169
179chondroitin sulfate catabolic process (GO:0030207)1.96162585
180detection of molecule of bacterial origin (GO:0032490)1.95045568
181negative regulation of cytosolic calcium ion concentration (GO:0051481)1.94613538
182positive regulation of mast cell degranulation (GO:0043306)1.94026692
183positive regulation of mast cell activation involved in immune response (GO:0033008)1.94026692
184negative regulation of interleukin-6 production (GO:0032715)1.93902293
185regulation of macrophage cytokine production (GO:0010935)1.92632954
186response to laminar fluid shear stress (GO:0034616)1.91104692
187cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.87747989
188positive regulation of regulated secretory pathway (GO:1903307)1.87211542
189locomotory exploration behavior (GO:0035641)1.87159129
190positive regulation of macrophage cytokine production (GO:0060907)1.87115184
191regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.86840504
192lipopolysaccharide-mediated signaling pathway (GO:0031663)1.86312607
193neutrophil mediated immunity (GO:0002446)1.85860809
194positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.85455051
195regulation of antigen processing and presentation (GO:0002577)1.84963035
196pinocytosis (GO:0006907)1.84795580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.87146826
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.69228535
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34294266
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.33818920
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.30052218
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29125749
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.24338829
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05588562
9REST_21632747_ChIP-Seq_MESCs_Mouse1.98847505
10* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96992935
11ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96119157
12ZNF274_21170338_ChIP-Seq_K562_Hela1.94026793
13DROSHA_22980978_ChIP-Seq_HELA_Human1.88474979
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84221027
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80389485
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80042602
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78923467
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78701933
19* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77251666
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74691323
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69546040
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68123713
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.66887693
24VDR_22108803_ChIP-Seq_LS180_Human1.63612094
25* SPI1_23127762_ChIP-Seq_K562_Human1.63387874
26VDR_24787735_ChIP-Seq_THP-1_Human1.59080276
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55630778
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.55073282
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.54196167
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53166914
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53027604
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52713010
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51691447
34BCAT_22108803_ChIP-Seq_LS180_Human1.50844880
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50705545
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47274159
37TP53_16413492_ChIP-PET_HCT116_Human1.47105422
38* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46805027
39P300_19829295_ChIP-Seq_ESCs_Human1.45553147
40GBX2_23144817_ChIP-Seq_PC3_Human1.44176909
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.44083947
42* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43534043
43IGF1R_20145208_ChIP-Seq_DFB_Human1.43524972
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43291306
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43291306
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42708947
47AR_21572438_ChIP-Seq_LNCaP_Human1.42253679
48SMAD4_21799915_ChIP-Seq_A2780_Human1.41934300
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.40457430
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38341136
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.37193628
52* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36806061
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36681605
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35584375
55TAF15_26573619_Chip-Seq_HEK293_Human1.35357904
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35171387
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.34644355
58* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34078227
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.31732913
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31197119
61* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31049334
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30643477
63RUNX_20019798_ChIP-Seq_JUKART_Human1.30463187
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29661995
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29429657
66TCF4_23295773_ChIP-Seq_U87_Human1.28354905
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.28195169
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28069874
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26646242
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25168932
71CJUN_26792858_Chip-Seq_BT549_Human1.25085403
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.25062425
73* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24789219
74* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24789219
75* STAT3_23295773_ChIP-Seq_U87_Human1.23884868
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23536173
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.23154733
78* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22946150
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22658374
80AHR_22903824_ChIP-Seq_MCF-7_Human1.22223280
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21870065
82ER_23166858_ChIP-Seq_MCF-7_Human1.21770842
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21416434
84* RNF2_27304074_Chip-Seq_ESCs_Mouse1.20616516
85AR_25329375_ChIP-Seq_VCAP_Human1.20010123
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.19423013
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18736461
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17391686
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.17287196
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17237319
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16565779
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16565779
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.15011105
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.14907964
95* KDM2B_26808549_Chip-Seq_K562_Human1.14775025
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.14712577
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13906270
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13603658
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13374733
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12825622
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12350959
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.12173988
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11524231
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.10277160
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09575166
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09172813
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08683217
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08275334
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08256973
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08072168
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08070496
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.07675093
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.07675093
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07033475
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06693682
116* EZH2_27294783_Chip-Seq_ESCs_Mouse1.05975780
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.05763031
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05118705
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05047204
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04612929
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04612051
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03912779
123* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03600434
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03299894
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03270444
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03118448
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03091103
128SMAD3_21741376_ChIP-Seq_ESCs_Human1.01820131
129TCF4_22108803_ChIP-Seq_LS180_Human1.01439040
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.00374592
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99539052
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.99091048
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98356577
134CBP_20019798_ChIP-Seq_JUKART_Human0.98356577
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98114738
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98004811
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.97720731
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97505249
139RNF2_27304074_Chip-Seq_NSC_Mouse0.96030778
140KDM2B_26808549_Chip-Seq_REH_Human0.96009980
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95679571
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95459681
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.95437080
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95382172
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95374404
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95070637
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.95047365
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94468365
149NANOG_19829295_ChIP-Seq_ESCs_Human0.94181898
150SOX2_19829295_ChIP-Seq_ESCs_Human0.94181898
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93284530
152* EZH2_27304074_Chip-Seq_ESCs_Mouse0.92881019
153VDR_24763502_ChIP-Seq_THP-1_Human0.92730308
154STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92036222
155* KDM2B_26808549_Chip-Seq_DND41_Human0.91816227
156RXR_22108803_ChIP-Seq_LS180_Human0.91286182
157* SCL_19346495_ChIP-Seq_HPC-7_Human0.91238707
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.90263749
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.89637081
160PU_27001747_Chip-Seq_BMDM_Mouse0.87833706
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86920327
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86878484
163GATA1_19941826_ChIP-Seq_K562_Human0.85426995
164BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84872299
165RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84639820
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84061335
167* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83686379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.29294807
2MP0003172_abnormal_lysosome_physiology3.76772428
3MP0004510_myositis3.08940314
4MP0000569_abnormal_digit_pigmentation2.96715279
5MP0005257_abnormal_intraocular_pressure2.91761095
6MP0008438_abnormal_cutaneous_collagen2.90197394
7MP0003880_abnormal_central_pattern2.82364707
8MP0009745_abnormal_behavioral_response2.72565944
9MP0003303_peritoneal_inflammation2.67540516
10MP0003635_abnormal_synaptic_transmissio2.42083493
11MP0002272_abnormal_nervous_system2.41330620
12MP0001501_abnormal_sleep_pattern2.39977058
13MP0004885_abnormal_endolymph2.36234503
14MP0003195_calcinosis2.35733727
15MP0003183_abnormal_peptide_metabolism2.32232550
16MP0001968_abnormal_touch/_nociception2.23789942
17MP0003300_gastrointestinal_ulcer2.19235193
18MP0003690_abnormal_glial_cell2.18853101
19MP0006276_abnormal_autonomic_nervous2.11100794
20MP0010386_abnormal_urinary_bladder2.10905915
21MP0002063_abnormal_learning/memory/cond2.06662218
22MP0002572_abnormal_emotion/affect_behav2.06544990
23MP0002735_abnormal_chemical_nociception2.04418601
24MP0001486_abnormal_startle_reflex2.01315485
25MP0002090_abnormal_vision2.01196602
26MP0003136_yellow_coat_color1.95025761
27MP0006082_CNS_inflammation1.94594733
28MP0005310_abnormal_salivary_gland1.92717022
29MP0004084_abnormal_cardiac_muscle1.91477273
30MP0002876_abnormal_thyroid_physiology1.90012352
31MP0005551_abnormal_eye_electrophysiolog1.88926343
32MP0004142_abnormal_muscle_tone1.83880547
33MP0003279_aneurysm1.83614045
34MP0002653_abnormal_ependyma_morphology1.82007450
35MP0005379_endocrine/exocrine_gland_phen1.80346256
36MP0001970_abnormal_pain_threshold1.79984402
37MP0002419_abnormal_innate_immunity1.79326826
38MP0003045_fibrosis1.76517964
39MP0000343_altered_response_to1.71685785
40MP0002163_abnormal_gland_morphology1.71498458
41MP0003566_abnormal_cell_adhesion1.70819373
42MP0002733_abnormal_thermal_nociception1.70181783
43MP0005646_abnormal_pituitary_gland1.66303090
44MP0001440_abnormal_grooming_behavior1.63327023
45MP0003787_abnormal_imprinting1.61863073
46MP0004858_abnormal_nervous_system1.61597476
47MP0004043_abnormal_pH_regulation1.59846433
48MP0001533_abnormal_skeleton_physiology1.57235831
49MP0001984_abnormal_olfaction1.56956949
50MP0005423_abnormal_somatic_nervous1.56106724
51MP0002557_abnormal_social/conspecific_i1.55218259
52MP0003436_decreased_susceptibility_to1.55211571
53MP0003828_pulmonary_edema1.54942738
54MP0003283_abnormal_digestive_organ1.53884314
55MP0002734_abnormal_mechanical_nocicepti1.52701570
56MP0008872_abnormal_physiological_respon1.52666169
57MP0004742_abnormal_vestibular_system1.52344165
58MP0001485_abnormal_pinna_reflex1.51278720
59MP0003191_abnormal_cellular_cholesterol1.51010239
60MP0002638_abnormal_pupillary_reflex1.49807778
61MP0002998_abnormal_bone_remodeling1.47939569
62MP0001986_abnormal_taste_sensitivity1.46064414
63MP0004270_analgesia1.45971353
64MP0002067_abnormal_sensory_capabilities1.45760902
65MP0000767_abnormal_smooth_muscle1.43632892
66MP0001958_emphysema1.43068469
67MP0001502_abnormal_circadian_rhythm1.42967734
68MP0001905_abnormal_dopamine_level1.41584177
69MP0003705_abnormal_hypodermis_morpholog1.41113227
70MP0000749_muscle_degeneration1.39156637
71MP0003075_altered_response_to1.36460168
72MP0002909_abnormal_adrenal_gland1.35657713
73MP0004036_abnormal_muscle_relaxation1.35319432
74MP0004185_abnormal_adipocyte_glucose1.34730655
75MP0002822_catalepsy1.34299120
76MP0004145_abnormal_muscle_electrophysio1.33953830
77MP0005167_abnormal_blood-brain_barrier1.31876709
78MP0002736_abnormal_nociception_after1.31373992
79MP0001851_eye_inflammation1.30922171
80MP0005464_abnormal_platelet_physiology1.30138263
81MP0001835_abnormal_antigen_presentation1.30107671
82MP0002148_abnormal_hypersensitivity_rea1.28825148
83MP0005386_behavior/neurological_phenoty1.27794220
84MP0004924_abnormal_behavior1.27794220
85MP0008569_lethality_at_weaning1.27512808
86MP0003879_abnormal_hair_cell1.26399747
87MP0003091_abnormal_cell_migration1.24007065
88MP0005670_abnormal_white_adipose1.22273551
89MP0009278_abnormal_bone_marrow1.19758829
90MP0004859_abnormal_synaptic_plasticity1.19139713
91MP0002102_abnormal_ear_morphology1.18708471
92MP0005000_abnormal_immune_tolerance1.17973578
93MP0003137_abnormal_impulse_conducting1.16260798
94MP0010368_abnormal_lymphatic_system1.16222802
95MP0000920_abnormal_myelination1.15673938
96MP0004133_heterotaxia1.14933816
97MP0008877_abnormal_DNA_methylation1.14839631
98MP0000751_myopathy1.13802491
99MP0003634_abnormal_glial_cell1.13421708
100MP0001299_abnormal_eye_distance/1.13232028
101MP0005645_abnormal_hypothalamus_physiol1.12282479
102MP0001963_abnormal_hearing_physiology1.12160423
103MP0005623_abnormal_meninges_morphology1.10845288
104MP0010329_abnormal_lipoprotein_level1.10055226
105MP0004484_altered_response_of1.07974665
106MP0004130_abnormal_muscle_cell1.07703556
107MP0003011_delayed_dark_adaptation1.07256453
108MP0000230_abnormal_systemic_arterial1.06171712
109MP0002166_altered_tumor_susceptibility1.05744700
110MP0005253_abnormal_eye_physiology1.05707413
111MP0008775_abnormal_heart_ventricle1.04954980
112MP0000604_amyloidosis1.03623304
113MP0002229_neurodegeneration1.02631526
114MP0003631_nervous_system_phenotype1.02072364
115MP0002972_abnormal_cardiac_muscle1.01333548
116MP0003122_maternal_imprinting1.00513297
117MP0002452_abnormal_antigen_presenting1.00138745
118MP0004272_abnormal_basement_membrane0.99612191
119MP0000631_abnormal_neuroendocrine_gland0.99146317
120MP0000778_abnormal_nervous_system0.98822819
121MP0003448_altered_tumor_morphology0.96823626
122MP0001765_abnormal_ion_homeostasis0.94507621
123MP0001790_abnormal_immune_system0.94383471
124MP0005387_immune_system_phenotype0.94383471
125MP0002837_dystrophic_cardiac_calcinosis0.94215948
126MP0005448_abnormal_energy_balance0.94091125
127MP0001879_abnormal_lymphatic_vessel0.93500388
128MP0002295_abnormal_pulmonary_circulatio0.93181744
129MP0005390_skeleton_phenotype0.92947365
130MP0005275_abnormal_skin_tensile0.92785124
131MP0005503_abnormal_tendon_morphology0.91741424
132MP0006072_abnormal_retinal_apoptosis0.91458454
133MP0000750_abnormal_muscle_regeneration0.91330711
134MP0005166_decreased_susceptibility_to0.89833835
135MP0002693_abnormal_pancreas_physiology0.88970941
136MP0001756_abnormal_urination0.88404959
137MP0002882_abnormal_neuron_morphology0.87891614
138MP0002066_abnormal_motor_capabilities/c0.87809576
139MP0004085_abnormal_heartbeat0.86213829
140MP0000026_abnormal_inner_ear0.84896133
141MP0009780_abnormal_chondrocyte_physiolo0.84757422
142MP0003633_abnormal_nervous_system0.84299079
143MP0005197_abnormal_uvea_morphology0.83787371
144MP0005535_abnormal_body_temperature0.83707296
145MP0002064_seizures0.83007276
146MP0003329_amyloid_beta_deposits0.82949965
147MP0009840_abnormal_foam_cell0.81838786
148MP0005076_abnormal_cell_differentiation0.81823487
149MP0009046_muscle_twitch0.81302684
150MP0005666_abnormal_adipose_tissue0.79966887
151MP0004087_abnormal_muscle_fiber0.79737626
152MP0009384_cardiac_valve_regurgitation0.79727284
153MP0003724_increased_susceptibility_to0.79298802
154MP0005025_abnormal_response_to0.78898242
155MP0002928_abnormal_bile_duct0.78524105
156MP0002723_abnormal_immune_serum0.77904461
157MP0009764_decreased_sensitivity_to0.77780734
158MP0005377_hearing/vestibular/ear_phenot0.76269018
159MP0003878_abnormal_ear_physiology0.76269018
160MP0004233_abnormal_muscle_weight0.76211532
161MP0004019_abnormal_vitamin_homeostasis0.75927580
162MP0000733_abnormal_muscle_development0.75787434
163MP0005375_adipose_tissue_phenotype0.73997761
164MP0005165_increased_susceptibility_to0.73492671
165MP0002896_abnormal_bone_mineralization0.72842886
166MP0000465_gastrointestinal_hemorrhage0.72496999
167MP0002277_abnormal_respiratory_mucosa0.71901550
168MP0005595_abnormal_vascular_smooth0.71815064
169MP0002933_joint_inflammation0.71632179
170MP0010630_abnormal_cardiac_muscle0.71584867
171MP0001944_abnormal_pancreas_morphology0.70911582
172MP0005647_abnormal_sex_gland0.70458472
173MP0005330_cardiomyopathy0.70284817
174MP0002108_abnormal_muscle_morphology0.70157636
175MP0000955_abnormal_spinal_cord0.69945423
176MP0000249_abnormal_blood_vessel0.69640997
177MP0004215_abnormal_myocardial_fiber0.69603823
178MP0002078_abnormal_glucose_homeostasis0.68243832
179MP0003953_abnormal_hormone_level0.67862964
180MP0005620_abnormal_muscle_contractility0.66255256
181MP0001819_abnormal_immune_cell0.65766888
182MP0004134_abnormal_chest_morphology0.65725798

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.28014190
2Dysostosis multiplex (HP:0000943)4.75736898
3Increased neuronal autofluorescent lipopigment (HP:0002074)4.55797061
4Vacuolated lymphocytes (HP:0001922)4.37481567
5Systemic lupus erythematosus (HP:0002725)4.30702303
6Progressive cerebellar ataxia (HP:0002073)4.02630907
7Abnormality of liposaccharide metabolism (HP:0010968)3.97477025
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.97477025
9Abnormality of glycolipid metabolism (HP:0010969)3.97477025
10Recurrent abscess formation (HP:0002722)3.87444949
11Focal motor seizures (HP:0011153)3.82544222
12Febrile seizures (HP:0002373)3.80659871
13Cerebral aneurysm (HP:0004944)3.79152867
14Arterial tortuosity (HP:0005116)3.65196553
15Mucopolysacchariduria (HP:0008155)3.53795841
16Urinary glycosaminoglycan excretion (HP:0003541)3.53795841
17Focal seizures (HP:0007359)3.46346725
18Abnormality of polysaccharide metabolism (HP:0011012)3.46217826
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.46217826
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.46217826
21Congenital stationary night blindness (HP:0007642)3.45732268
22Glomerulonephritis (HP:0000099)3.35990706
23Atonic seizures (HP:0010819)3.33720939
24Vascular tortuosity (HP:0004948)3.33479404
25Hyperventilation (HP:0002883)3.32598954
26Recurrent bacterial skin infections (HP:0005406)3.31729801
27Hemiparesis (HP:0001269)3.24730828
28Pancreatic fibrosis (HP:0100732)3.17402458
29Aortic aneurysm (HP:0004942)3.13826290
30Axonal loss (HP:0003447)3.12964598
31Disinhibition (HP:0000734)3.11395828
32Eczematoid dermatitis (HP:0000976)3.09070259
33Gaze-evoked nystagmus (HP:0000640)3.09046232
34Decreased circulating renin level (HP:0003351)2.93674148
35Pancreatic cysts (HP:0001737)2.92221095
36Hematochezia (HP:0002573)2.92003346
37Polydipsia (HP:0001959)2.90542264
38Abnormal drinking behavior (HP:0030082)2.90542264
39Abnormality of midbrain morphology (HP:0002418)2.89279372
40Molar tooth sign on MRI (HP:0002419)2.89279372
41Retinal atrophy (HP:0001105)2.88246674
42True hermaphroditism (HP:0010459)2.83808262
43Aortic dissection (HP:0002647)2.80914407
44Large for gestational age (HP:0001520)2.79447381
45Spondylolisthesis (HP:0003302)2.79184379
46Genetic anticipation (HP:0003743)2.78895686
47Abolished electroretinogram (ERG) (HP:0000550)2.77005498
48Myokymia (HP:0002411)2.74694066
49Dialeptic seizures (HP:0011146)2.74567363
50Nephronophthisis (HP:0000090)2.74467212
51Type II lissencephaly (HP:0007260)2.71674613
52Limb dystonia (HP:0002451)2.66059666
53Medial flaring of the eyebrow (HP:0010747)2.64239483
54Asymmetric septal hypertrophy (HP:0001670)2.63984464
55Thick nail (HP:0001805)2.59823117
56Absence seizures (HP:0002121)2.54004300
57Abnormality of macrophages (HP:0004311)2.53909409
58Mutism (HP:0002300)2.49494588
59Prolonged QT interval (HP:0001657)2.48636306
60Neuronal loss in central nervous system (HP:0002529)2.46573741
61Abnormal rod and cone electroretinograms (HP:0008323)2.42595307
62Supranuclear gaze palsy (HP:0000605)2.42244207
63Abnormality of the renal medulla (HP:0100957)2.41189764
64Cystic liver disease (HP:0006706)2.38608912
65Loss of speech (HP:0002371)2.38345672
66Abnormality of the renal cortex (HP:0011035)2.36175477
67Metabolic alkalosis (HP:0200114)2.35991626
68Generalized tonic-clonic seizures (HP:0002069)2.33755791
69Epileptic encephalopathy (HP:0200134)2.32885489
70Polyuria (HP:0000103)2.32336636
71Broad-based gait (HP:0002136)2.32011255
72Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30803638
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28964197
74Inability to walk (HP:0002540)2.27065799
75Premature rupture of membranes (HP:0001788)2.26793483
76Abnormal eating behavior (HP:0100738)2.25706271
77Striae distensae (HP:0001065)2.24779863
78Gait imbalance (HP:0002141)2.24561587
79Scapular winging (HP:0003691)2.24194595
80Papilledema (HP:0001085)2.21193962
81Urethral obstruction (HP:0000796)2.20646419
82Polyphagia (HP:0002591)2.19308488
83Stomach cancer (HP:0012126)2.19079843
84Attenuation of retinal blood vessels (HP:0007843)2.18124549
85Congenital sensorineural hearing impairment (HP:0008527)2.17106374
86Inappropriate behavior (HP:0000719)2.16361774
87Abnormal EKG (HP:0003115)2.16353386
88Epileptiform EEG discharges (HP:0011182)2.14071865
89Abnormal urine output (HP:0012590)2.12366421
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.12026010
91Absent/shortened dynein arms (HP:0200106)2.12026010
92Abnormality of renin-angiotensin system (HP:0000847)2.11444080
93Aneurysm (HP:0002617)2.10770242
94Vertebral compression fractures (HP:0002953)2.10653170
95Disproportionate tall stature (HP:0001519)2.10221562
96Absent speech (HP:0001344)2.08614485
97Hypomagnesemia (HP:0002917)2.08024868
98Gingivitis (HP:0000230)2.07626919
99Thoracic kyphosis (HP:0002942)2.06841716
100Recurrent gram-negative bacterial infections (HP:0005420)2.06689724
101Progressive visual loss (HP:0000529)2.04983528
102Decreased central vision (HP:0007663)2.04450886
103Increased circulating renin level (HP:0000848)2.04055623
104Neurofibrillary tangles (HP:0002185)2.03297124
105J-shaped sella turcica (HP:0002680)2.02615837
106Shallow orbits (HP:0000586)2.01950098
107Keratoconus (HP:0000563)2.01823882
108Increased corneal curvature (HP:0100692)2.01823882
109Pathologic fracture (HP:0002756)2.01539008
110EEG with generalized epileptiform discharges (HP:0011198)2.01090465
111Chronic hepatic failure (HP:0100626)2.00585884
112Nephritis (HP:0000123)1.99160129
113Syncope (HP:0001279)1.95101022
114Hypsarrhythmia (HP:0002521)1.94710557
115Anxiety (HP:0000739)1.93978237
116Abnormal respiratory motile cilium morphology (HP:0005938)1.93609356
117Abnormal respiratory epithelium morphology (HP:0012253)1.93609356
118Congenital primary aphakia (HP:0007707)1.92531692
119Mitral valve prolapse (HP:0001634)1.91503944
120Ventricular fibrillation (HP:0001663)1.91177942
121Tubular atrophy (HP:0000092)1.89637409
122Bone pain (HP:0002653)1.89227011
123Abnormality of renal excretion (HP:0011036)1.88557476
124Postural instability (HP:0002172)1.88258313
125Status epilepticus (HP:0002133)1.88236165
126Hypothermia (HP:0002045)1.88189729
127Ketoacidosis (HP:0001993)1.87738434
128Progressive inability to walk (HP:0002505)1.87368972
129Protrusio acetabuli (HP:0003179)1.86354758
130Genital tract atresia (HP:0001827)1.85715644
131Protruding tongue (HP:0010808)1.85107297
132Fair hair (HP:0002286)1.85004450
133Widely spaced teeth (HP:0000687)1.84782682
134Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84553360
135Recurrent skin infections (HP:0001581)1.83848372
136Apathy (HP:0000741)1.83519152
137Agitation (HP:0000713)1.82711417
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.82467522
139Spontaneous hematomas (HP:0007420)1.82191864
140Broad metatarsal (HP:0001783)1.81525621
141Left ventricular hypertrophy (HP:0001712)1.79764371
142Hypokalemic alkalosis (HP:0001949)1.79444590
143Ulnar claw (HP:0001178)1.78631354
144Rapidly progressive (HP:0003678)1.77572621
145Furrowed tongue (HP:0000221)1.77279133
146Stomatitis (HP:0010280)1.77055300
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.76923228
148Hypoplasia of the fovea (HP:0007750)1.76923228
149Increased CSF protein (HP:0002922)1.76082875
150Hyperlipoproteinemia (HP:0010980)1.75912372
151Coarse hair (HP:0002208)1.75457529
152Hemiplegia (HP:0002301)1.75340001
153Complement deficiency (HP:0004431)1.75082837
154Ovoid vertebral bodies (HP:0003300)1.74376202
155Clumsiness (HP:0002312)1.72122791
156Abnormal ciliary motility (HP:0012262)1.72098775
157Abnormality of the sella turcica (HP:0002679)1.71071739
158Abnormality of the thoracic spine (HP:0100711)1.69851267
159Atrial fibrillation (HP:0005110)1.69454863
160Hyperaldosteronism (HP:0000859)1.69249825
161Action tremor (HP:0002345)1.69120536
162Vaginal atresia (HP:0000148)1.69049227
163Diminished motivation (HP:0000745)1.68008398
164Nephrogenic diabetes insipidus (HP:0009806)1.67339194
165Peripheral demyelination (HP:0011096)1.66969945
166Abnormality of the calf musculature (HP:0001430)1.66612530
167Exotropia (HP:0000577)1.63815507
168Joint stiffness (HP:0001387)1.62287357
169Myocardial infarction (HP:0001658)1.60812642
170Hand muscle atrophy (HP:0009130)1.60208484
171Distal upper limb amyotrophy (HP:0007149)1.59779902
172Upper limb amyotrophy (HP:0009129)1.59779902
173Progressive neurologic deterioration (HP:0002344)1.58366945
174Cerebral inclusion bodies (HP:0100314)1.57637060
175Facial diplegia (HP:0001349)1.57615509
176Abnormality of the lumbar spine (HP:0100712)1.57239897
177Broad ribs (HP:0000885)1.56971941
178Dilatation of the ascending aorta (HP:0005111)1.56437930
179Macroorchidism (HP:0000053)1.56387019
180Pulmonary artery stenosis (HP:0004415)1.56109486
181Abnormality of complement system (HP:0005339)1.55457512
182Hypoplasia of the odontoid process (HP:0003311)1.55176893
183Abnormality of the odontoid process (HP:0003310)1.54923676
184Dementia (HP:0000726)1.53795673
185Hypoplastic ischia (HP:0003175)1.53770550
186Tetraparesis (HP:0002273)1.53528249
187Diplopia (HP:0000651)1.52145667
188Abnormality of binocular vision (HP:0011514)1.52145667
189Primary atrial arrhythmia (HP:0001692)1.51652490
190Chronic obstructive pulmonary disease (HP:0006510)1.51441245
191Obstructive lung disease (HP:0006536)1.51441245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.71275716
2CAMK1G2.62596351
3CAMK1D2.56249646
4NTRK32.54415585
5PINK12.51465896
6ERN12.47909622
7RIPK42.41078276
8TAOK32.33600300
9TRIB32.25434216
10ADRBK22.17099215
11EPHB12.16220179
12BLK2.14058843
13BMPR1B2.09972566
14DMPK2.00985552
15WNK41.99485180
16RIPK11.92502018
17TTN1.91380623
18FES1.86498188
19CAMKK21.83027397
20CASK1.82430640
21INSRR1.80168441
22PKN21.78083360
23WNK31.74956990
24FGFR21.74204890
25NTRK21.68086446
26ACVR1B1.67469793
27GRK11.66397023
28CSF1R1.61346539
29EPHA41.59900630
30SIK11.57184814
31JAK11.56370766
32TXK1.54935441
33IRAK41.54193431
34MAP4K21.51858700
35MARK11.50131248
36CAMKK11.44718412
37MAPK131.41753745
38NTRK11.37886304
39AKT31.36446367
40KIT1.35493897
41LATS11.34690381
42MAPK151.34564236
43MAP3K41.32473876
44PTK61.31211816
45GRK71.27517954
46IRAK31.26410515
47PAK31.24792735
48PAK41.18302623
49SIK21.18133199
50PRKCG1.16792286
51TBK11.16336125
52TYK21.14205704
53PNCK1.08268883
54PTK21.05784544
55OXSR11.03542231
56UHMK10.98661157
57ADRBK10.98521583
58TNIK0.97790594
59STK390.97122063
60SGK4940.96146571
61SGK2230.96146571
62MAP3K70.95545806
63NLK0.95537319
64WNK10.94587959
65TYRO30.94401461
66GRK50.92211693
67HCK0.91863315
68PDPK10.91429525
69CSK0.90201877
70RET0.89790527
71FGR0.88187381
72KDR0.87942881
73PTK2B0.84287943
74MAP3K130.84173933
75PAK60.82067437
76FRK0.80803586
77ITK0.79602559
78CAMK2A0.79515232
79PDGFRB0.78981390
80PRKD10.78641089
81SCYL20.78119121
82NEK90.78071677
83PRKCH0.77670081
84MAP2K30.77354089
85IRAK20.77116497
86IRAK10.74756771
87PDK10.74095751
88PDGFRA0.74001715
89PRKCQ0.73538123
90JAK20.73437973
91MAP3K20.71878997
92DAPK20.71305754
93NUAK10.70013200
94STK380.69548205
95MAP3K140.69458903
96MAPK120.68154397
97SGK30.67129147
98CAMK10.67025863
99CAMK40.66940982
100ICK0.66899823
101KSR20.65776874
102CDK80.64139309
103CAMK2B0.62881725
104DYRK1A0.62534725
105CDK50.62273647
106TRPM70.61694352
107PKN10.61621001
108CLK10.61125993
109PRKCZ0.60714727
110SGK10.60128233
111FYN0.59343131
112PRKG10.58778041
113TNK20.57704212
114SYK0.57386798
115DYRK20.57212532
116BMX0.56070588
117PIK3CG0.56025502
118FGFR30.55522067
119HIPK20.54091134
120MYLK0.53834253
121CAMK2D0.53674613
122PHKG20.53373978
123PHKG10.53373978
124PAK20.53161287
125RPS6KA20.53127444
126LMTK20.52867916
127SRC0.51808413
128LCK0.51089730
129MAP2K60.51048466
130STK110.50569575
131ROCK10.50128730
132SGK20.49949436
133MAP4K10.49688901
134PRKACA0.49523745
135TIE10.49296301
136MAP3K90.49262713
137PLK20.48823368
138TGFBR10.48707992
139MATK0.47935097
140MOS0.47844465
141TAOK10.47307743
142MARK20.46553065
143ZAP700.46512961
144PRKD20.46482214
145PIK3CA0.46016336
146MAPK70.45876599
147IKBKB0.45725107
148PRKD30.45498616
149JAK30.45246354
150EPHA30.44535417
151MAP2K10.44404123
152PRKCE0.44070683
153FER0.43867244
154PRKAA20.43764949
155LYN0.43711056
156PRKCA0.42807451
157GRK60.41741665
158STK38L0.41388527

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.74553306
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.44826122
3Other glycan degradation_Homo sapiens_hsa005112.39668456
4Lysosome_Homo sapiens_hsa041422.37402967
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20666152
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97039332
7Ovarian steroidogenesis_Homo sapiens_hsa049131.95609683
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.89900015
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88400522
10Linoleic acid metabolism_Homo sapiens_hsa005911.76584093
11Osteoclast differentiation_Homo sapiens_hsa043801.74921979
12Staphylococcus aureus infection_Homo sapiens_hsa051501.70396402
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69443774
14Amphetamine addiction_Homo sapiens_hsa050311.67299335
15Phototransduction_Homo sapiens_hsa047441.62492613
16Butanoate metabolism_Homo sapiens_hsa006501.56024438
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55097101
18Tryptophan metabolism_Homo sapiens_hsa003801.51162866
19Taste transduction_Homo sapiens_hsa047421.49405048
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44133697
21Cocaine addiction_Homo sapiens_hsa050301.42137111
22Histidine metabolism_Homo sapiens_hsa003401.36555743
23Leishmaniasis_Homo sapiens_hsa051401.32672006
24Dilated cardiomyopathy_Homo sapiens_hsa054141.31647762
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31321923
26Serotonergic synapse_Homo sapiens_hsa047261.31306158
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29341724
28Type II diabetes mellitus_Homo sapiens_hsa049301.28512048
29Nitrogen metabolism_Homo sapiens_hsa009101.26834676
30ABC transporters_Homo sapiens_hsa020101.24605429
31Dopaminergic synapse_Homo sapiens_hsa047281.24367490
32Phagosome_Homo sapiens_hsa041451.21573023
33Rheumatoid arthritis_Homo sapiens_hsa053231.20903965
34Tuberculosis_Homo sapiens_hsa051521.19315881
35B cell receptor signaling pathway_Homo sapiens_hsa046621.18490356
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18071756
37Synaptic vesicle cycle_Homo sapiens_hsa047211.17264182
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16900008
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15976527
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11531434
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10661062
42Pertussis_Homo sapiens_hsa051331.09674941
43Renin secretion_Homo sapiens_hsa049241.07552275
44Focal adhesion_Homo sapiens_hsa045101.06919578
45Malaria_Homo sapiens_hsa051441.06645789
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05675466
47Regulation of autophagy_Homo sapiens_hsa041401.05293273
48Cardiac muscle contraction_Homo sapiens_hsa042601.05219694
49Platelet activation_Homo sapiens_hsa046111.04450441
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04190891
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.04173982
52Amoebiasis_Homo sapiens_hsa051461.03807959
53Ether lipid metabolism_Homo sapiens_hsa005651.03652216
54Collecting duct acid secretion_Homo sapiens_hsa049661.03591596
55Chronic myeloid leukemia_Homo sapiens_hsa052201.03565767
56Renal cell carcinoma_Homo sapiens_hsa052111.02913795
57Pancreatic cancer_Homo sapiens_hsa052121.01848256
58Toxoplasmosis_Homo sapiens_hsa051450.98253081
59Chemokine signaling pathway_Homo sapiens_hsa040620.97479566
60Salmonella infection_Homo sapiens_hsa051320.96480030
61Endocytosis_Homo sapiens_hsa041440.94155293
62Caffeine metabolism_Homo sapiens_hsa002320.93948990
63Salivary secretion_Homo sapiens_hsa049700.93772297
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93698896
65Bile secretion_Homo sapiens_hsa049760.92110730
66beta-Alanine metabolism_Homo sapiens_hsa004100.91731250
67Morphine addiction_Homo sapiens_hsa050320.91250391
68ECM-receptor interaction_Homo sapiens_hsa045120.90961906
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90736073
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.90589692
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90212768
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.90171283
73Oxytocin signaling pathway_Homo sapiens_hsa049210.89768215
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.89727601
75Cholinergic synapse_Homo sapiens_hsa047250.89457733
76Estrogen signaling pathway_Homo sapiens_hsa049150.88695226
77Glioma_Homo sapiens_hsa052140.88370097
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88232132
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.87670455
80Mineral absorption_Homo sapiens_hsa049780.87442097
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86410274
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86244959
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.85534382
84mTOR signaling pathway_Homo sapiens_hsa041500.85412676
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85099823
86Vibrio cholerae infection_Homo sapiens_hsa051100.83724619
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83686799
88Proteoglycans in cancer_Homo sapiens_hsa052050.83465309
89Circadian entrainment_Homo sapiens_hsa047130.82895572
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82837104
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82439081
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82181201
93Insulin secretion_Homo sapiens_hsa049110.81025797
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79969233
95Prion diseases_Homo sapiens_hsa050200.78044700
96Long-term depression_Homo sapiens_hsa047300.77321785
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76293422
98cAMP signaling pathway_Homo sapiens_hsa040240.76067158
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.75480498
100TNF signaling pathway_Homo sapiens_hsa046680.75469324
101VEGF signaling pathway_Homo sapiens_hsa043700.74340880
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74244716
103GnRH signaling pathway_Homo sapiens_hsa049120.74127491
104Pancreatic secretion_Homo sapiens_hsa049720.73799947
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73485043
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73390663
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73149103
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72844373
109Glutamatergic synapse_Homo sapiens_hsa047240.72820330
110Dorso-ventral axis formation_Homo sapiens_hsa043200.71735567
111Rap1 signaling pathway_Homo sapiens_hsa040150.71497476
112Type I diabetes mellitus_Homo sapiens_hsa049400.71404415
113Sphingolipid metabolism_Homo sapiens_hsa006000.71259891
114Gastric acid secretion_Homo sapiens_hsa049710.70972909
115Viral myocarditis_Homo sapiens_hsa054160.70371634
116Circadian rhythm_Homo sapiens_hsa047100.70128715
117Arachidonic acid metabolism_Homo sapiens_hsa005900.70101325
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70000328
119Adherens junction_Homo sapiens_hsa045200.69739868
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.69555500
121Notch signaling pathway_Homo sapiens_hsa043300.68761573
122GABAergic synapse_Homo sapiens_hsa047270.68426732
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68339908
124Thyroid hormone synthesis_Homo sapiens_hsa049180.67589514
125Insulin resistance_Homo sapiens_hsa049310.66729997
126Folate biosynthesis_Homo sapiens_hsa007900.65952893
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65924182
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65394311
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65318953
130Prolactin signaling pathway_Homo sapiens_hsa049170.64868254
131Olfactory transduction_Homo sapiens_hsa047400.64269263
132Ras signaling pathway_Homo sapiens_hsa040140.64253616
133Melanoma_Homo sapiens_hsa052180.63637310
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63113078
135Long-term potentiation_Homo sapiens_hsa047200.63041374
136ErbB signaling pathway_Homo sapiens_hsa040120.62408672
137Calcium signaling pathway_Homo sapiens_hsa040200.62201913
138Acute myeloid leukemia_Homo sapiens_hsa052210.61945698
139MAPK signaling pathway_Homo sapiens_hsa040100.61296819
140Choline metabolism in cancer_Homo sapiens_hsa052310.60965675
141HIF-1 signaling pathway_Homo sapiens_hsa040660.60739847
142Inositol phosphate metabolism_Homo sapiens_hsa005620.60538030
143Shigellosis_Homo sapiens_hsa051310.60235305
144Retinol metabolism_Homo sapiens_hsa008300.55750383
145Peroxisome_Homo sapiens_hsa041460.54612216
146Chemical carcinogenesis_Homo sapiens_hsa052040.54492389
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.54104652
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52652497
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52144537
150Glycerolipid metabolism_Homo sapiens_hsa005610.48780187
151Axon guidance_Homo sapiens_hsa043600.44981128
152Oxidative phosphorylation_Homo sapiens_hsa001900.43087567
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42507234
154Selenocompound metabolism_Homo sapiens_hsa004500.41778155
155Melanogenesis_Homo sapiens_hsa049160.40009327
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.38143963
157Fatty acid degradation_Homo sapiens_hsa000710.33959273
158Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33914531
159PPAR signaling pathway_Homo sapiens_hsa033200.33790631
160Autoimmune thyroid disease_Homo sapiens_hsa053200.33181709

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