MALSU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.17111391
2viral transcription (GO:0019083)5.88281364
3translational termination (GO:0006415)5.81028530
4chaperone-mediated protein transport (GO:0072321)5.63606522
5maturation of SSU-rRNA (GO:0030490)5.50420386
6ribosomal small subunit biogenesis (GO:0042274)5.43691055
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.27199631
8DNA deamination (GO:0045006)5.12440819
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.04579088
10translational elongation (GO:0006414)5.03291878
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.93319503
12cotranslational protein targeting to membrane (GO:0006613)4.80996681
13protein targeting to ER (GO:0045047)4.79296973
14translational initiation (GO:0006413)4.77245580
15respiratory electron transport chain (GO:0022904)4.74208016
16* ribosomal large subunit biogenesis (GO:0042273)4.65020505
17electron transport chain (GO:0022900)4.60990610
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.60253136
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.52997030
20cellular protein complex disassembly (GO:0043624)4.50546681
21protein localization to endoplasmic reticulum (GO:0070972)4.50034534
22viral life cycle (GO:0019058)4.43482623
23protein complex biogenesis (GO:0070271)4.17075431
24formation of translation preinitiation complex (GO:0001731)4.08975820
25translation (GO:0006412)4.07293355
26mitochondrial respiratory chain complex assembly (GO:0033108)4.03389005
27kinetochore organization (GO:0051383)4.00160511
28kinetochore assembly (GO:0051382)3.96601683
29protein complex disassembly (GO:0043241)3.96110683
30* regulation of mitochondrial translation (GO:0070129)3.96003394
31* ribonucleoprotein complex biogenesis (GO:0022613)3.95184392
32proteasome assembly (GO:0043248)3.91885957
33DNA strand elongation involved in DNA replication (GO:0006271)3.86949501
34CENP-A containing nucleosome assembly (GO:0034080)3.82775132
35macromolecular complex disassembly (GO:0032984)3.81806506
36telomere maintenance via semi-conservative replication (GO:0032201)3.80727269
37protein targeting to mitochondrion (GO:0006626)3.76258420
38chromatin remodeling at centromere (GO:0031055)3.75204897
39mitotic metaphase plate congression (GO:0007080)3.73249420
40spliceosomal snRNP assembly (GO:0000387)3.69764276
41protein neddylation (GO:0045116)3.66450151
42DNA strand elongation (GO:0022616)3.65042858
43rRNA processing (GO:0006364)3.64256299
44purine nucleobase biosynthetic process (GO:0009113)3.63940544
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.61035056
46spliceosomal complex assembly (GO:0000245)3.59609481
47establishment of protein localization to mitochondrion (GO:0072655)3.56798315
48rRNA metabolic process (GO:0016072)3.52941720
49rRNA modification (GO:0000154)3.49712935
50protein localization to mitochondrion (GO:0070585)3.49015423
51termination of RNA polymerase III transcription (GO:0006386)3.47739952
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.47739952
53telomere maintenance via recombination (GO:0000722)3.46315709
54nucleobase biosynthetic process (GO:0046112)3.46079922
55DNA replication initiation (GO:0006270)3.43247579
56respiratory chain complex IV assembly (GO:0008535)3.42895904
57DNA damage response, detection of DNA damage (GO:0042769)3.42805482
58mRNA catabolic process (GO:0006402)3.40471233
59* cellular component biogenesis (GO:0044085)3.36438381
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36023361
61DNA replication-independent nucleosome organization (GO:0034724)3.35256273
62DNA replication-independent nucleosome assembly (GO:0006336)3.35256273
63metaphase plate congression (GO:0051310)3.35243903
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33258148
65pseudouridine synthesis (GO:0001522)3.32687589
66DNA replication checkpoint (GO:0000076)3.31042471
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29110929
68mitotic recombination (GO:0006312)3.27031761
69energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26205617
70ATP synthesis coupled proton transport (GO:0015986)3.26205617
71RNA catabolic process (GO:0006401)3.24706020
72ribosome assembly (GO:0042255)3.22232665
73transcription-coupled nucleotide-excision repair (GO:0006283)3.22137606
74inner mitochondrial membrane organization (GO:0007007)3.20958185
75ribosome biogenesis (GO:0042254)3.18866958
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17241458
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15655040
78cytochrome complex assembly (GO:0017004)3.15409020
79oxidative phosphorylation (GO:0006119)3.14745893
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14446744
81viral mRNA export from host cell nucleus (GO:0046784)3.14395600
82telomere maintenance via telomere lengthening (GO:0010833)3.12000823
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11357700
84histone exchange (GO:0043486)3.10066546
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.05778572
86establishment of viral latency (GO:0019043)3.04942189
87DNA unwinding involved in DNA replication (GO:0006268)3.03919120
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02890814
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.02890814
90NADH dehydrogenase complex assembly (GO:0010257)3.02890814
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02079668
92establishment of integrated proviral latency (GO:0075713)2.99960121
93protein targeting to membrane (GO:0006612)2.99707245
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96139646
95ATP biosynthetic process (GO:0006754)2.94146133
96negative regulation of ligase activity (GO:0051352)2.93918792
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93918792
98regulation of cellular amino acid metabolic process (GO:0006521)2.91828029
997-methylguanosine mRNA capping (GO:0006370)2.91623247
100protein deneddylation (GO:0000338)2.91087815
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90478460
102mitochondrial transport (GO:0006839)2.89467170
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89215223
104establishment of chromosome localization (GO:0051303)2.89154520
105pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88563340
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88480190
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88480190
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87446326
109cullin deneddylation (GO:0010388)2.87093184
110RNA capping (GO:0036260)2.86894746
1117-methylguanosine RNA capping (GO:0009452)2.86894746
112GTP biosynthetic process (GO:0006183)2.86873122
113intracellular protein transmembrane import (GO:0044743)2.86697363
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86088342
115purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85525592
116peptidyl-histidine modification (GO:0018202)2.84187757
117DNA replication-dependent nucleosome organization (GO:0034723)2.83869320
118DNA replication-dependent nucleosome assembly (GO:0006335)2.83869320
119transcription elongation from RNA polymerase I promoter (GO:0006362)2.83173313
120termination of RNA polymerase I transcription (GO:0006363)2.82872517
121positive regulation of ligase activity (GO:0051351)2.82743563
122purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82658393
123signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82094889
124signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82094889
125signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82094889
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81786103
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81786103
128ncRNA processing (GO:0034470)2.79747500
129transcription from RNA polymerase I promoter (GO:0006360)2.79272689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.78552934
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.78909753
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00392010
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64950730
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.43837223
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.41787310
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36498780
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25869294
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.24341452
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.23971620
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21615285
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11841108
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07331126
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01758127
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95063007
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82204677
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74266843
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71040183
19XRN2_22483619_ChIP-Seq_HELA_Human2.58772525
20VDR_23849224_ChIP-Seq_CD4+_Human2.51096651
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50531630
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47444522
23DCP1A_22483619_ChIP-Seq_HELA_Human2.40641122
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36668648
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35670229
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32721441
27TTF2_22483619_ChIP-Seq_HELA_Human2.20124070
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18369069
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13973924
30FOXP3_21729870_ChIP-Seq_TREG_Human2.10993714
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10206316
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01309742
33ELK1_19687146_ChIP-ChIP_HELA_Human2.00416040
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95159750
35GABP_19822575_ChIP-Seq_HepG2_Human1.93298769
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89523713
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86901442
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84206552
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.78832222
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78811562
41AR_21909140_ChIP-Seq_LNCAP_Human1.76320113
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.74475489
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73667610
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72225831
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.71439229
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70083992
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68809626
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68563480
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67953272
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67167907
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62456859
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55517463
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53034898
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50365204
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47898186
56CIITA_25753668_ChIP-Seq_RAJI_Human1.47199381
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37781029
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36912017
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36622213
60MYC_18940864_ChIP-ChIP_HL60_Human1.33494187
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29219401
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28921532
63KDM5A_27292631_Chip-Seq_BREAST_Human1.28199952
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25986737
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25879298
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25197774
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25104723
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24483044
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.23744206
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.22804783
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.16126479
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.15607467
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15452724
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13971637
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12468242
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11723422
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10328815
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08649766
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07683991
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.07022045
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06109980
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05580693
83TFEB_21752829_ChIP-Seq_HELA_Human1.01611373
84EWS_26573619_Chip-Seq_HEK293_Human1.00765082
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98825838
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96774088
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96162899
88FUS_26573619_Chip-Seq_HEK293_Human0.96047749
89SALL1_21062744_ChIP-ChIP_HESCs_Human0.95788573
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95681178
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93291199
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93117096
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92582320
94ZNF274_21170338_ChIP-Seq_K562_Hela0.92314911
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91986943
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90873906
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.89717419
98TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89655051
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89501081
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86245298
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85371705
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84865604
103TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83276972
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82881725
105EGR1_19374776_ChIP-ChIP_THP-1_Human0.82708993
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82317206
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82044618
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81324778
109SPI1_23547873_ChIP-Seq_NB4_Human0.81131493
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80411090
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79851077
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78354944
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.77135614
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.74138492
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73666445
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73069636
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65977947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53469867
2MP0009379_abnormal_foot_pigmentation3.97721968
3MP0004957_abnormal_blastocyst_morpholog3.96097226
4MP0003111_abnormal_nucleus_morphology3.68537887
5MP0010094_abnormal_chromosome_stability3.68330826
6MP0003077_abnormal_cell_cycle3.45569259
7MP0008058_abnormal_DNA_repair3.00047716
8MP0008057_abnormal_DNA_replication2.61279848
9MP0008007_abnormal_cellular_replicative2.48195231
10MP0008932_abnormal_embryonic_tissue2.48068730
11MP0003123_paternal_imprinting2.32698691
12MP0010030_abnormal_orbit_morphology1.87750968
13MP0002234_abnormal_pharynx_morphology1.86825288
14MP0003315_abnormal_perineum_morphology1.86435908
15MP0003186_abnormal_redox_activity1.84925015
16MP0001529_abnormal_vocalization1.83949912
17MP0003786_premature_aging1.80225081
18MP0003567_abnormal_fetal_cardiomyocyte1.78930190
19MP0009053_abnormal_anal_canal1.71629861
20MP0001730_embryonic_growth_arrest1.71473809
21MP0003718_maternal_effect1.68271640
22MP0000350_abnormal_cell_proliferation1.65830821
23MP0003806_abnormal_nucleotide_metabolis1.52423071
24MP0001293_anophthalmia1.52194656
25MP0008877_abnormal_DNA_methylation1.48311861
26MP0006036_abnormal_mitochondrial_physio1.46098855
27MP0006292_abnormal_olfactory_placode1.45550864
28MP0001697_abnormal_embryo_size1.45531716
29MP0000490_abnormal_crypts_of1.45181177
30MP0002396_abnormal_hematopoietic_system1.44731538
31MP0003941_abnormal_skin_development1.41077644
32MP0002132_abnormal_respiratory_system1.40504674
33MP0001672_abnormal_embryogenesis/_devel1.40037451
34MP0005380_embryogenesis_phenotype1.40037451
35MP0000313_abnormal_cell_death1.38314775
36MP0002837_dystrophic_cardiac_calcinosis1.30990534
37MP0002233_abnormal_nose_morphology1.30256049
38MP0003119_abnormal_digestive_system1.27825854
39MP0003890_abnormal_embryonic-extraembry1.26517407
40MP0003984_embryonic_growth_retardation1.25052199
41MP0002088_abnormal_embryonic_growth/wei1.24733939
42MP0005499_abnormal_olfactory_system1.24006479
43MP0005394_taste/olfaction_phenotype1.24006479
44MP0002085_abnormal_embryonic_tissue1.21438512
45MP0000049_abnormal_middle_ear1.20581216
46MP0002697_abnormal_eye_size1.18465412
47MP0002080_prenatal_lethality1.18338451
48MP0002102_abnormal_ear_morphology1.18220608
49MP0000631_abnormal_neuroendocrine_gland1.16737739
50MP0009697_abnormal_copulation1.16717000
51MP0006072_abnormal_retinal_apoptosis1.14461736
52MP0004133_heterotaxia1.13883036
53MP0001188_hyperpigmentation1.13609680
54MP0006035_abnormal_mitochondrial_morpho1.13078738
55MP0002210_abnormal_sex_determination1.12879932
56MP0000537_abnormal_urethra_morphology1.09567461
57MP0003011_delayed_dark_adaptation1.08491786
58MP0002160_abnormal_reproductive_system1.07869716
59MP0000566_synostosis1.06730949
60MP0001764_abnormal_homeostasis1.06309758
61MP0004808_abnormal_hematopoietic_stem1.05070187
62MP0004197_abnormal_fetal_growth/weight/1.04509482
63MP0004142_abnormal_muscle_tone1.04120150
64MP0002938_white_spotting1.04047745
65MP0002019_abnormal_tumor_incidence1.02101310
66MP0000750_abnormal_muscle_regeneration1.02009399
67MP0002086_abnormal_extraembryonic_tissu1.01897056
68MP0003121_genomic_imprinting0.99644002
69MP0005389_reproductive_system_phenotype0.99404503
70MP0005174_abnormal_tail_pigmentation0.98107708
71MP0002736_abnormal_nociception_after0.97381571
72MP0002638_abnormal_pupillary_reflex0.95307635
73MP0002095_abnormal_skin_pigmentation0.92781944
74MP0001286_abnormal_eye_development0.92502232
75MP0001485_abnormal_pinna_reflex0.92281987
76MP0001853_heart_inflammation0.91726057
77MP0001145_abnormal_male_reproductive0.91417434
78MP0010352_gastrointestinal_tract_polyps0.90766706
79MP0002084_abnormal_developmental_patter0.90438778
80MP0003136_yellow_coat_color0.90334772
81MP0004233_abnormal_muscle_weight0.89543441
82MP0003755_abnormal_palate_morphology0.88741475
83MP0001119_abnormal_female_reproductive0.88274008
84MP0001919_abnormal_reproductive_system0.88117465
85MP0003938_abnormal_ear_development0.87218688
86MP0000358_abnormal_cell_content/0.86649763
87MP0002163_abnormal_gland_morphology0.86539528
88MP0005075_abnormal_melanosome_morpholog0.86520949
89MP0005367_renal/urinary_system_phenotyp0.85226727
90MP0000516_abnormal_urinary_system0.85226727
91MP0009333_abnormal_splenocyte_physiolog0.84901612
92MP0002111_abnormal_tail_morphology0.84877721
93MP0003221_abnormal_cardiomyocyte_apopto0.83722525
94MP0003698_abnormal_male_reproductive0.80973736
95MP0003646_muscle_fatigue0.80715675
96MP0000858_altered_metastatic_potential0.80161109
97MP0005410_abnormal_fertilization0.79815576
98MP0000653_abnormal_sex_gland0.79315961
99MP0009250_abnormal_appendicular_skeleto0.76911391
100MP0001905_abnormal_dopamine_level0.76224049
101MP0000703_abnormal_thymus_morphology0.75218159
102MP0000015_abnormal_ear_pigmentation0.74045803
103MP0002277_abnormal_respiratory_mucosa0.73938873
104MP0000647_abnormal_sebaceous_gland0.73900588
105MP0009672_abnormal_birth_weight0.70839648
106MP0008789_abnormal_olfactory_epithelium0.70001905
107MP0002653_abnormal_ependyma_morphology0.69803201
108MP0005187_abnormal_penis_morphology0.69255687
109MP0001984_abnormal_olfaction0.68208058
110MP0005377_hearing/vestibular/ear_phenot0.68003398
111MP0003878_abnormal_ear_physiology0.68003398
112MP0003861_abnormal_nervous_system0.67671585
113MP0000749_muscle_degeneration0.66736092
114MP0002751_abnormal_autonomic_nervous0.66414066
115MP0003937_abnormal_limbs/digits/tail_de0.65423167
116MP0000372_irregular_coat_pigmentation0.65161760
117MP0002161_abnormal_fertility/fecundity0.64964083
118MP0006276_abnormal_autonomic_nervous0.64842010
119MP0003942_abnormal_urinary_system0.64799520
120MP0003122_maternal_imprinting0.64785224
121MP0005408_hypopigmentation0.63817775
122MP0001929_abnormal_gametogenesis0.63544538
123MP0005084_abnormal_gallbladder_morpholo0.63022701
124MP0002092_abnormal_eye_morphology0.62844090
125MP0002722_abnormal_immune_system0.60408731
126MP0003828_pulmonary_edema0.60272770
127MP0003763_abnormal_thymus_physiology0.60246352
128MP0000762_abnormal_tongue_morphology0.59411313
129MP0003385_abnormal_body_wall0.58695418
130MP0000432_abnormal_head_morphology0.56914788
131MP0003936_abnormal_reproductive_system0.56412559
132MP0004381_abnormal_hair_follicle0.56258219

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.05961185
2Abnormality of cells of the erythroid lineage (HP:0012130)4.91832832
3Abnormal number of erythroid precursors (HP:0012131)4.65060668
4Increased hepatocellular lipid droplets (HP:0006565)4.10413699
5Macrocytic anemia (HP:0001972)3.99884829
6Colon cancer (HP:0003003)3.89225661
7Mitochondrial inheritance (HP:0001427)3.87044668
8Acute necrotizing encephalopathy (HP:0006965)3.86791098
9Lipid accumulation in hepatocytes (HP:0006561)3.86673783
10Pallor (HP:0000980)3.79140275
11Increased CSF lactate (HP:0002490)3.61040248
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.60442188
13Hepatocellular necrosis (HP:0001404)3.47464932
14Chromsome breakage (HP:0040012)3.44252226
15Abnormal mitochondria in muscle tissue (HP:0008316)3.41876340
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.37159569
17Birth length less than 3rd percentile (HP:0003561)3.35365814
18Hepatic necrosis (HP:0002605)3.32669125
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24427459
20Progressive macrocephaly (HP:0004481)3.21696588
21Acute encephalopathy (HP:0006846)3.15640323
22Breast hypoplasia (HP:0003187)3.04169963
23Exertional dyspnea (HP:0002875)3.03530931
24Increased serum lactate (HP:0002151)3.01904927
25Microvesicular hepatic steatosis (HP:0001414)2.99437481
26Oral leukoplakia (HP:0002745)2.99142448
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93752697
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93752697
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91516509
30Absent thumb (HP:0009777)2.86863861
31Abnormal hemoglobin (HP:0011902)2.84272621
32Respiratory difficulties (HP:0002880)2.78438366
33Hyperalaninemia (HP:0003348)2.74231116
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74231116
35Abnormality of alanine metabolism (HP:0010916)2.74231116
36Meckel diverticulum (HP:0002245)2.71812918
37Microretrognathia (HP:0000308)2.71660222
38Abnormality of the preputium (HP:0100587)2.70153510
39Septo-optic dysplasia (HP:0100842)2.69007523
40Trismus (HP:0000211)2.66095592
41Exercise intolerance (HP:0003546)2.63126666
42Renal Fanconi syndrome (HP:0001994)2.62732087
43Abnormality of the ileum (HP:0001549)2.56717482
44Leukodystrophy (HP:0002415)2.54688434
45Increased serum pyruvate (HP:0003542)2.54299246
46Abnormality of glycolysis (HP:0004366)2.54299246
47Aplastic anemia (HP:0001915)2.52975893
48Triphalangeal thumb (HP:0001199)2.51842823
49Patellar aplasia (HP:0006443)2.50838322
50Increased intramyocellular lipid droplets (HP:0012240)2.47511843
51Hyperglycinemia (HP:0002154)2.46572831
52Degeneration of anterior horn cells (HP:0002398)2.44540179
53Abnormality of the anterior horn cell (HP:0006802)2.44540179
54Cerebral edema (HP:0002181)2.41302369
55Rough bone trabeculation (HP:0100670)2.39110652
56Aplasia/Hypoplasia of the patella (HP:0006498)2.39040579
57Lactic acidosis (HP:0003128)2.36921159
58Abnormality of chromosome stability (HP:0003220)2.35844977
59Horseshoe kidney (HP:0000085)2.34308736
6011 pairs of ribs (HP:0000878)2.33823003
613-Methylglutaconic aciduria (HP:0003535)2.30411840
62Cleft eyelid (HP:0000625)2.28277182
63Carpal bone hypoplasia (HP:0001498)2.26665506
64Absent radius (HP:0003974)2.26058536
65Secondary amenorrhea (HP:0000869)2.25473425
66Optic disc pallor (HP:0000543)2.24794358
67Increased muscle lipid content (HP:0009058)2.24302978
68Lethargy (HP:0001254)2.23713361
69Abnormality of renal resorption (HP:0011038)2.23707953
70Multiple enchondromatosis (HP:0005701)2.23006062
71Respiratory failure (HP:0002878)2.20754484
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.18755389
73Congenital, generalized hypertrichosis (HP:0004540)2.18274128
74Neoplasm of the colon (HP:0100273)2.15988764
75Neoplasm of the pancreas (HP:0002894)2.15630735
76Nemaline bodies (HP:0003798)2.15355321
77Nausea (HP:0002018)2.14142432
78Selective tooth agenesis (HP:0001592)2.13886699
79Abnormality of serum amino acid levels (HP:0003112)2.13008397
80Abnormality of methionine metabolism (HP:0010901)2.11664508
81Abnormal trabecular bone morphology (HP:0100671)2.10759835
82Absent forearm bone (HP:0003953)2.07634175
83Aplasia involving forearm bones (HP:0009822)2.07634175
84Glycosuria (HP:0003076)2.07374419
85Abnormality of urine glucose concentration (HP:0011016)2.07374419
86Medulloblastoma (HP:0002885)2.06512227
87Abnormal lung lobation (HP:0002101)2.06488665
88Absent septum pellucidum (HP:0001331)2.06217715
89Premature graying of hair (HP:0002216)2.05710558
90Facial cleft (HP:0002006)2.05333452
91Methylmalonic aciduria (HP:0012120)2.04340147
92Biliary tract neoplasm (HP:0100574)2.02051064
93Type I transferrin isoform profile (HP:0003642)2.01514419
94Methylmalonic acidemia (HP:0002912)2.00254282
95Generalized aminoaciduria (HP:0002909)1.96263792
96Abnormality of reticulocytes (HP:0004312)1.96091311
97X-linked dominant inheritance (HP:0001423)1.92143958
98Abnormality of pyrimidine metabolism (HP:0004353)1.92031553
99CNS demyelination (HP:0007305)1.90728873
100Premature ovarian failure (HP:0008209)1.89991509
101Abnormality of the labia minora (HP:0012880)1.88388502
102Poor head control (HP:0002421)1.87731932
103Agnosia (HP:0010524)1.86577445
104Supernumerary spleens (HP:0009799)1.85588184
105Intestinal fistula (HP:0100819)1.84673094
106Hyperphosphaturia (HP:0003109)1.83641028
107Amniotic constriction ring (HP:0009775)1.83377872
108Abnormality of placental membranes (HP:0011409)1.83377872
109Hypoplasia of the radius (HP:0002984)1.82793903
110Stenosis of the external auditory canal (HP:0000402)1.81820314
111Maternal diabetes (HP:0009800)1.80957122
112Sclerocornea (HP:0000647)1.79805764
113Sparse eyelashes (HP:0000653)1.79761371
114Abnormal number of incisors (HP:0011064)1.79576302
115Myelodysplasia (HP:0002863)1.79420316
116Cellular immunodeficiency (HP:0005374)1.79246387
117Megaloblastic anemia (HP:0001889)1.78856507
118Duplicated collecting system (HP:0000081)1.78825135
119Cerebral hypomyelination (HP:0006808)1.78755137
120Rectal fistula (HP:0100590)1.78558830
121Rectovaginal fistula (HP:0000143)1.78558830
122Duodenal stenosis (HP:0100867)1.78159599
123Small intestinal stenosis (HP:0012848)1.78159599
124Bone marrow hypocellularity (HP:0005528)1.77892720
125Aplasia/hypoplasia of the uterus (HP:0008684)1.77439835
126Pancreatic fibrosis (HP:0100732)1.77034151
127Pancytopenia (HP:0001876)1.76750634
128Abnormal protein glycosylation (HP:0012346)1.76481182
129Abnormal glycosylation (HP:0012345)1.76481182
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76481182
131Abnormal protein N-linked glycosylation (HP:0012347)1.76481182
132Reduced antithrombin III activity (HP:0001976)1.74281499
133Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73557160
134Atresia of the external auditory canal (HP:0000413)1.72880085
135Anophthalmia (HP:0000528)1.71623126
136Partial duplication of thumb phalanx (HP:0009944)1.70882861
137Abnormality of the septum pellucidum (HP:0007375)1.70644088
138Ectopic kidney (HP:0000086)1.66672555
139Median cleft lip (HP:0000161)1.65875744
140Pancreatic cysts (HP:0001737)1.65227213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44773337
2NME23.99733304
3VRK23.82234506
4EIF2AK13.55969237
5WEE13.51063662
6TLK13.48335661
7SRPK13.45835149
8STK162.43893672
9ACVR1B2.42496120
10NEK22.28432633
11CDC72.24748213
12ZAK2.19884562
13IRAK32.16445200
14PLK42.13201821
15DYRK32.05263653
16RPS6KA42.02963878
17EIF2AK32.01541867
18TTK1.92507266
19MKNK11.75650635
20PLK11.73156973
21PBK1.68564431
22AURKB1.67182285
23VRK11.66935464
24NME11.63956073
25BRSK21.55309667
26PDK21.52310212
27CDK71.49394498
28AURKA1.48184532
29MKNK21.45932197
30CDK191.42294327
31TESK21.38701047
32BRAF1.38381447
33TNIK1.32688241
34PNCK1.32096934
35CDK121.29618475
36WNK41.28007331
37EIF2AK21.27387555
38KDR1.23541865
39ATR1.21656224
40CHEK21.19737293
41EPHA21.18251453
42DYRK21.17216798
43TAF11.14637614
44NEK91.12080190
45PIM21.10741225
46STK391.08353741
47MAP3K111.07961844
48BCKDK1.05445281
49PASK1.04380117
50RPS6KB21.02959622
51MAP4K21.01206493
52NEK11.00389396
53FLT30.99682136
54IRAK40.99320736
55CSNK1G30.98048927
56PINK10.97624619
57STK38L0.95586258
58WNK30.93836845
59PLK30.93261584
60CSNK1G10.91212496
61MAP2K70.90659341
62CDK80.88520561
63TGFBR10.86571824
64CSNK1G20.84968184
65CDK40.84157921
66RPS6KA50.84154673
67STK40.82724006
68MAP3K80.78829027
69BRD40.78068620
70CSNK2A10.77434577
71ABL20.77271172
72OBSCN0.75856789
73ERBB40.75605242
74TRIM280.75150965
75PIM10.70860156
76CHEK10.70824876
77STK240.68223556
78BLK0.66846749
79SCYL20.65542629
80MAP3K120.65012047
81TESK10.64695569
82MELK0.64615831
83CSNK2A20.64319161
84TEC0.63814755
85MST1R0.63317065
86CSNK1A1L0.61614041
87ATM0.60990419
88BRSK10.58053604
89TAOK20.58044869
90PRKCI0.57175624
91EPHB20.56251991
92YES10.56142073
93MUSK0.54944188
94INSRR0.54567719
95CCNB10.53851100
96MAP3K100.52934413
97MAP3K30.52218687
98ERBB30.52098622
99PRKCG0.51859166
100MAPKAPK50.51560912
101CSNK1E0.51430252
102CDK20.51180336
103PAK10.50127886
104MINK10.49356957
105ARAF0.49045735
106MST40.47979535
107ILK0.47734779
108PAK40.46986306
109LIMK10.45798846
110NUAK10.42677686
111IRAK10.42230104
112MYLK0.41253076
113PIK3CG0.41063916
114GRK10.40717169
115OXSR10.39940533
116MAP2K30.39342719
117AKT30.38472269
118CDK30.37904847
119BMPR1B0.36883782
120CDK10.36729603
121CDK60.34407505
122DAPK30.33630109
123CASK0.33473418
124LRRK20.32452036
125DMPK0.32355492
126CAMK10.32251139
127PHKG20.32052872
128PHKG10.32052872
129PLK20.31972509
130MARK30.31024233
131CSNK1A10.30558674
132STK100.30534821
133IRAK20.28753537
134STK30.28074512
135TSSK60.26562899
136NLK0.25855869
137ZAP700.25014920

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.29494938
2DNA replication_Homo sapiens_hsa030303.84480123
3Mismatch repair_Homo sapiens_hsa034303.65830701
4Proteasome_Homo sapiens_hsa030503.60378796
5RNA polymerase_Homo sapiens_hsa030203.57920344
6Spliceosome_Homo sapiens_hsa030403.01858286
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01770047
8Homologous recombination_Homo sapiens_hsa034402.76803088
9Pyrimidine metabolism_Homo sapiens_hsa002402.60290208
10Nucleotide excision repair_Homo sapiens_hsa034202.56987164
11RNA transport_Homo sapiens_hsa030132.54393700
12Base excision repair_Homo sapiens_hsa034102.45485057
13One carbon pool by folate_Homo sapiens_hsa006702.26181954
14Oxidative phosphorylation_Homo sapiens_hsa001902.24589790
15Parkinsons disease_Homo sapiens_hsa050122.19128642
16Fanconi anemia pathway_Homo sapiens_hsa034602.08818456
17Cell cycle_Homo sapiens_hsa041101.92832698
18Huntingtons disease_Homo sapiens_hsa050161.87819006
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78240674
20Non-homologous end-joining_Homo sapiens_hsa034501.76300997
21Basal transcription factors_Homo sapiens_hsa030221.75055022
22Protein export_Homo sapiens_hsa030601.68531726
23RNA degradation_Homo sapiens_hsa030181.63393201
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54389712
25Folate biosynthesis_Homo sapiens_hsa007901.49180239
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36469109
27Alzheimers disease_Homo sapiens_hsa050101.32825456
28p53 signaling pathway_Homo sapiens_hsa041151.32287348
29Systemic lupus erythematosus_Homo sapiens_hsa053221.29391786
30Purine metabolism_Homo sapiens_hsa002301.27699626
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23960568
32Fatty acid elongation_Homo sapiens_hsa000621.16894200
33mRNA surveillance pathway_Homo sapiens_hsa030151.15080462
34Sulfur relay system_Homo sapiens_hsa041221.10943209
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07135850
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04185091
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97216581
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.93786992
39Epstein-Barr virus infection_Homo sapiens_hsa051690.92485995
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88297276
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84751765
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77620220
43Cardiac muscle contraction_Homo sapiens_hsa042600.76044317
44Selenocompound metabolism_Homo sapiens_hsa004500.75790942
45Glutathione metabolism_Homo sapiens_hsa004800.74600404
46Sulfur metabolism_Homo sapiens_hsa009200.74379806
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.71425773
48Herpes simplex infection_Homo sapiens_hsa051680.67843808
49Pentose phosphate pathway_Homo sapiens_hsa000300.67266369
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.67189910
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57462862
52Basal cell carcinoma_Homo sapiens_hsa052170.54830681
53Arachidonic acid metabolism_Homo sapiens_hsa005900.54798802
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54562788
55Metabolic pathways_Homo sapiens_hsa011000.54438320
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54401419
57Legionellosis_Homo sapiens_hsa051340.52667962
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50994238
59Carbon metabolism_Homo sapiens_hsa012000.50715922
60Galactose metabolism_Homo sapiens_hsa000520.46831251
61Vitamin B6 metabolism_Homo sapiens_hsa007500.45965530
62HTLV-I infection_Homo sapiens_hsa051660.45726434
63Viral carcinogenesis_Homo sapiens_hsa052030.45646723
64Biosynthesis of amino acids_Homo sapiens_hsa012300.45597691
65Collecting duct acid secretion_Homo sapiens_hsa049660.44714176
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43111057
67Oocyte meiosis_Homo sapiens_hsa041140.38438301
68Thyroid cancer_Homo sapiens_hsa052160.37536444
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.37252759
70Antigen processing and presentation_Homo sapiens_hsa046120.37252640
71Butanoate metabolism_Homo sapiens_hsa006500.35829534
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34386156
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34320082
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34186990
75Phenylalanine metabolism_Homo sapiens_hsa003600.33194279
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32872675
77Arginine and proline metabolism_Homo sapiens_hsa003300.32752222
78Fatty acid degradation_Homo sapiens_hsa000710.32569817
79Phototransduction_Homo sapiens_hsa047440.32365204
80Nitrogen metabolism_Homo sapiens_hsa009100.32276940
81Vitamin digestion and absorption_Homo sapiens_hsa049770.31797099
82Arginine biosynthesis_Homo sapiens_hsa002200.31380959
83Fructose and mannose metabolism_Homo sapiens_hsa000510.30556699
84TGF-beta signaling pathway_Homo sapiens_hsa043500.29326291
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29264562
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27903143
87Chemical carcinogenesis_Homo sapiens_hsa052040.27712576
88Apoptosis_Homo sapiens_hsa042100.26802833
89Fatty acid metabolism_Homo sapiens_hsa012120.26662794
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26271925
91Tryptophan metabolism_Homo sapiens_hsa003800.26096534
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24782006
93Small cell lung cancer_Homo sapiens_hsa052220.24334735
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.23308090
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23306399
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22570931
97Hippo signaling pathway_Homo sapiens_hsa043900.22034798
98Hedgehog signaling pathway_Homo sapiens_hsa043400.21777361
99Alcoholism_Homo sapiens_hsa050340.21735869
100Linoleic acid metabolism_Homo sapiens_hsa005910.20807958
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20124378
102MicroRNAs in cancer_Homo sapiens_hsa052060.19470034
103Peroxisome_Homo sapiens_hsa041460.19463693
104Wnt signaling pathway_Homo sapiens_hsa043100.18713980
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.18325132
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17685537
107N-Glycan biosynthesis_Homo sapiens_hsa005100.17482789
108Steroid biosynthesis_Homo sapiens_hsa001000.17463933
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17295865
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16799198
111Regulation of autophagy_Homo sapiens_hsa041400.16370419
112Measles_Homo sapiens_hsa051620.14126847
113HIF-1 signaling pathway_Homo sapiens_hsa040660.13659201
114Primary immunodeficiency_Homo sapiens_hsa053400.12084429
115beta-Alanine metabolism_Homo sapiens_hsa004100.10799241
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10348152
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10292768
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10027216
119Pyruvate metabolism_Homo sapiens_hsa006200.09765093
120Propanoate metabolism_Homo sapiens_hsa006400.08870663
121Retinol metabolism_Homo sapiens_hsa008300.08590880
122Tyrosine metabolism_Homo sapiens_hsa003500.08564245
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.08557649

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