MALL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.99144997
2intestinal absorption (GO:0050892)7.15517321
3intestinal cholesterol absorption (GO:0030299)6.56954767
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.52496149
5hemidesmosome assembly (GO:0031581)6.24359531
6angiotensin maturation (GO:0002003)6.03933757
7maintenance of gastrointestinal epithelium (GO:0030277)5.05058694
8vitamin A metabolic process (GO:0006776)5.03217736
9NADH metabolic process (GO:0006734)4.88217256
10regulation of water loss via skin (GO:0033561)4.71516422
11positive regulation of guanylate cyclase activity (GO:0031284)4.67984259
12positive regulation of pseudopodium assembly (GO:0031274)4.67474932
13establishment of skin barrier (GO:0061436)4.54751411
14keratinization (GO:0031424)4.54346136
15adhesion of symbiont to host cell (GO:0044650)4.53852988
16virion attachment to host cell (GO:0019062)4.53852988
17negative regulation of keratinocyte proliferation (GO:0010839)4.52806665
18renal system process involved in regulation of blood volume (GO:0001977)4.46193338
19flavonoid metabolic process (GO:0009812)4.31590107
20sulfate transmembrane transport (GO:1902358)4.21355999
21bile acid and bile salt transport (GO:0015721)4.19573150
22epoxygenase P450 pathway (GO:0019373)4.17887288
23regulation of pseudopodium assembly (GO:0031272)4.16896326
24actin filament depolymerization (GO:0030042)4.14600705
25keratinocyte proliferation (GO:0043616)4.13855608
26cellular glucuronidation (GO:0052695)4.12599197
27regulation of cellular extravasation (GO:0002691)4.11989527
28fat-soluble vitamin biosynthetic process (GO:0042362)4.10579860
29epithelial structure maintenance (GO:0010669)4.10383312
30surfactant homeostasis (GO:0043129)4.10380137
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.06514248
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.06514248
33intestinal epithelial cell development (GO:0060576)4.03987713
34regulation of systemic arterial blood pressure (GO:0003073)4.03387722
35renal filtration (GO:0097205)4.02669424
36uronic acid metabolic process (GO:0006063)4.00046537
37glucuronate metabolic process (GO:0019585)4.00046537
38digestive system process (GO:0022600)3.93103018
39diol metabolic process (GO:0034311)3.91582956
40regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.89970173
41sphingoid metabolic process (GO:0046519)3.89894145
42intermediate filament organization (GO:0045109)3.82621551
43lipoprotein transport (GO:0042953)3.78695499
44adhesion of symbiont to host (GO:0044406)3.74295522
45glomerular filtration (GO:0003094)3.72443881
46regulation of cGMP biosynthetic process (GO:0030826)3.72238396
47thyroid hormone metabolic process (GO:0042403)3.69711865
48antimicrobial humoral response (GO:0019730)3.68069062
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.60574097
50striated muscle atrophy (GO:0014891)3.54230872
51fructose metabolic process (GO:0006000)3.51828092
52antibacterial humoral response (GO:0019731)3.50606377
53multicellular organismal water homeostasis (GO:0050891)3.46335258
54UDP-N-acetylglucosamine metabolic process (GO:0006047)3.42605137
55keratinocyte differentiation (GO:0030216)3.42374853
56receptor guanylyl cyclase signaling pathway (GO:0007168)3.39964907
57drug metabolic process (GO:0017144)3.37994802
58skeletal muscle adaptation (GO:0043501)3.31570493
59sulfate transport (GO:0008272)3.29305522
60sphingosine metabolic process (GO:0006670)3.27641539
61O-glycan processing (GO:0016266)3.24870158
62renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.24372654
63calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.23493331
64hormone catabolic process (GO:0042447)3.22444041
65drug catabolic process (GO:0042737)3.16549086
66cellular response to nitric oxide (GO:0071732)3.15439826
67peptide hormone processing (GO:0016486)3.14360628
68positive regulation of epidermis development (GO:0045684)3.14066080
69epithelial cell-cell adhesion (GO:0090136)3.12327341
70transcytosis (GO:0045056)3.10008717
71regulation of triglyceride catabolic process (GO:0010896)3.09801947
72phospholipid efflux (GO:0033700)3.09442578
73positive regulation of epidermal cell differentiation (GO:0045606)3.08905970
74regulation of metalloenzyme activity (GO:0048552)3.06558822
75auditory receptor cell differentiation (GO:0042491)3.05953174
76oligosaccharide biosynthetic process (GO:0009312)3.04713633
77positive regulation of Cdc42 GTPase activity (GO:0043089)3.04392789
78regulation of cGMP metabolic process (GO:0030823)3.04095237
79positive regulation of glycoprotein biosynthetic process (GO:0010560)3.03651922
80chemical homeostasis within a tissue (GO:0048875)3.02449320
81response to hepatocyte growth factor (GO:0035728)3.00958223
82cellular response to hepatocyte growth factor stimulus (GO:0035729)3.00958223
83cytidine metabolic process (GO:0046087)2.98810365
84cytidine catabolic process (GO:0006216)2.98810365
85cytidine deamination (GO:0009972)2.98810365
86phospholipid scrambling (GO:0017121)2.98445750
87ventricular cardiac muscle cell action potential (GO:0086005)2.97232581
88urea cycle (GO:0000050)2.95270266
89renal absorption (GO:0070293)2.94787542
90sulfur compound transport (GO:0072348)2.93455141
91negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.92062706
92epidermal cell differentiation (GO:0009913)2.90270599
93diacylglycerol metabolic process (GO:0046339)2.90006012
94citrulline biosynthetic process (GO:0019240)2.89844438
95regulation of bile acid biosynthetic process (GO:0070857)2.89547812
96water homeostasis (GO:0030104)2.88573528
97positive regulation of lipoprotein lipase activity (GO:0051006)2.88149956
98positive regulation of triglyceride lipase activity (GO:0061365)2.88149956
99nucleoside diphosphate biosynthetic process (GO:0009133)2.87904345
100regulation of cholesterol homeostasis (GO:2000188)2.87459811
101positive regulation of respiratory burst (GO:0060267)2.86928768
102thyroid hormone generation (GO:0006590)2.85845017
103cyclooxygenase pathway (GO:0019371)2.85080840
104muscle atrophy (GO:0014889)2.83309507
105arginine metabolic process (GO:0006525)2.79283853
106regulation of viral release from host cell (GO:1902186)2.79100910
107lipoprotein metabolic process (GO:0042157)2.79096030
108drug transmembrane transport (GO:0006855)2.78745135
109keratinocyte development (GO:0003334)2.78331343
110positive regulation of glycoprotein metabolic process (GO:1903020)2.77791932
111cobalamin metabolic process (GO:0009235)2.74712129
112peptide cross-linking (GO:0018149)2.74618260
113positive regulation of cGMP biosynthetic process (GO:0030828)2.74442340
114urea metabolic process (GO:0019627)2.74313380
115detection of bacterium (GO:0016045)2.74263240
116bicarbonate transport (GO:0015701)2.73254266
117peptide catabolic process (GO:0043171)2.72451786
118negative regulation of protein tyrosine kinase activity (GO:0061099)2.71722392
119hair cycle (GO:0042633)2.71241062
120molting cycle (GO:0042303)2.71241062
121phosphatidylserine acyl-chain remodeling (GO:0036150)2.69834509
122regulation of transforming growth factor beta1 production (GO:0032908)2.69681224
123digestion (GO:0007586)2.69123344
124response to nitric oxide (GO:0071731)2.68724665
125regulation of cardioblast differentiation (GO:0051890)2.68537078
126glycolipid catabolic process (GO:0019377)2.67690050
127regulation of keratinocyte proliferation (GO:0010837)2.67107615
128sphingomyelin metabolic process (GO:0006684)2.66946036
129cell communication involved in cardiac conduction (GO:0086065)2.66041458
130cellular response to reactive nitrogen species (GO:1902170)2.65966619
131phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.64570776
132regulation of chemokine secretion (GO:0090196)2.63869722
133atrioventricular valve morphogenesis (GO:0003181)2.63054232
134glutamine family amino acid biosynthetic process (GO:0009084)2.62637541
135thrombin receptor signaling pathway (GO:0070493)2.61885540
136sodium ion homeostasis (GO:0055078)2.61582824
137modified amino acid transport (GO:0072337)2.57728455
138transepithelial transport (GO:0070633)2.55180816
139interferon-gamma secretion (GO:0072643)2.53132250
140regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.52376422
141regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.50977784
142endocrine process (GO:0050886)2.50977784
143regulation of systemic arterial blood pressure by hormone (GO:0001990)2.50977784
144regulation of guanylate cyclase activity (GO:0031282)2.49071158
145skin morphogenesis (GO:0043589)2.47900080
146positive regulation of p38MAPK cascade (GO:1900745)2.45986595
147branching involved in labyrinthine layer morphogenesis (GO:0060670)2.45674212
148ectoderm development (GO:0007398)2.45542800
149innate immune response in mucosa (GO:0002227)2.44753307
150regulation of vitamin metabolic process (GO:0030656)2.44183733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.34671346
2* CDX2_20551321_ChIP-Seq_CACO-2_Human3.36156768
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.19750454
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43766465
5* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.42200748
6* SOX2_20726797_ChIP-Seq_SW620_Human2.34345282
7GATA4_25053715_ChIP-Seq_YYC3_Human2.12117425
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.11623548
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01616972
10TP63_17297297_ChIP-ChIP_HaCaT_Human11.4223201
11GATA6_25053715_ChIP-Seq_YYC3_Human1.91627332
12CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87704559
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86355700
14* ESR1_21235772_ChIP-Seq_MCF-7_Human1.78236421
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.71456839
16P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71366891
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70471448
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69067237
19KLF5_25053715_ChIP-Seq_YYC3_Human1.68373361
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61942927
21SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61719426
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.61648336
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59991266
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59991266
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58100931
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53466750
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51713097
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50096835
29RACK7_27058665_Chip-Seq_MCF-7_Human1.49886246
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48590662
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48216544
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47843689
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47085729
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44963025
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43769514
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43687920
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42118279
38ZNF263_19887448_ChIP-Seq_K562_Human1.41603380
39* TCF4_18268006_ChIP-ChIP_LS174T_Human1.36685604
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33503820
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.33113192
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30476542
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.29204808
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29109416
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28697629
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27147664
47CLOCK_20551151_ChIP-Seq_293T_Human1.25111343
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22240688
49* ATF3_27146783_Chip-Seq_COLON_Human1.22131728
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21161997
51* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17309623
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16121188
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15495528
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.15220201
55* CJUN_26792858_Chip-Seq_BT549_Human1.14754428
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11132016
57* AR_21909140_ChIP-Seq_LNCAP_Human1.10310123
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10165259
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09997147
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.08851519
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07796582
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07106266
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06449072
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03670207
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03530595
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.03346850
67CDX2_22108803_ChIP-Seq_LS180_Human1.02940214
68BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02404780
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01006569
70RXR_22108803_ChIP-Seq_LS180_Human1.00930286
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00216901
72TP63_22573176_ChIP-Seq_HFKS_Human0.99735427
73* TP63_23658742_ChIP-Seq_EP156T_Human0.97808144
74BP1_19119308_ChIP-ChIP_Hs578T_Human0.97537300
75EGR1_19032775_ChIP-ChIP_M12_Human0.96058899
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94407744
77LXR_22292898_ChIP-Seq_THP-1_Human0.94355950
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93383613
79* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92714082
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92204946
81IRF8_22096565_ChIP-ChIP_GC-B_Human0.91616265
82GATA2_19941826_ChIP-Seq_K562_Human0.91385949
83* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90555540
84AHR_22903824_ChIP-Seq_MCF-7_Human0.89674928
85FOXA2_19822575_ChIP-Seq_HepG2_Human0.88276622
86HNF4A_19822575_ChIP-Seq_HepG2_Human0.86990368
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86710490
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86644595
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86360430
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86085635
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85068245
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84934457
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83905889
94* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83651302
95* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83272981
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.82891879
97BCAT_22108803_ChIP-Seq_LS180_Human0.82879570
98* TET1_21451524_ChIP-Seq_MESCs_Mouse0.82799962
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82732182
100CTCF_27219007_Chip-Seq_Bcells_Human0.82519166
101* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80749035
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.79769967
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79584497
104TBX20_22328084_ChIP-Seq_HEART_Mouse0.78213077
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.78213077
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76469541
107SMAD_19615063_ChIP-ChIP_OVARY_Human0.76429768
108* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76102990
109IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75840987
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75807534
111P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75461357
112DROSHA_22980978_ChIP-Seq_HELA_Human0.73567632
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73019664
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72131122
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.71127698
116TP53_16413492_ChIP-PET_HCT116_Human0.71009926
117* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70152130
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68878668
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.68558977
120CREB1_26743006_Chip-Seq_LNCaP_Human0.66969075
121TP53_18474530_ChIP-ChIP_U2OS_Human0.66274547
122KDM2B_26808549_Chip-Seq_K562_Human0.65419030
123NANOG_20526341_ChIP-Seq_ESCs_Human0.65067141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.54388590
2MP0005360_urolithiasis4.66297189
3MP0002796_impaired_skin_barrier4.32298125
4MP0001666_abnormal_nutrient_absorption3.58336385
5MP0010678_abnormal_skin_adnexa3.10026942
6MP0004264_abnormal_extraembryonic_tissu3.09922128
7MP0003705_abnormal_hypodermis_morpholog2.98073976
8MP0005365_abnormal_bile_salt2.67111328
9MP0005501_abnormal_skin_physiology2.60731845
10MP0000383_abnormal_hair_follicle2.48127070
11MP0003866_abnormal_defecation2.38289590
12MP0000462_abnormal_digestive_system2.33664089
13MP0002254_reproductive_system_inflammat2.32917213
14MP0002098_abnormal_vibrissa_morphology2.31344827
15MP0003453_abnormal_keratinocyte_physiol2.21986289
16MP0000537_abnormal_urethra_morphology2.18757286
17MP0003941_abnormal_skin_development2.16298465
18MP0001216_abnormal_epidermal_layer2.15784595
19MP0005409_darkened_coat_color2.14383804
20MP0010352_gastrointestinal_tract_polyps2.11957668
21MP0000467_abnormal_esophagus_morphology2.08183763
22MP0005275_abnormal_skin_tensile2.07985775
23MP0000579_abnormal_nail_morphology1.93002344
24MP0004947_skin_inflammation1.92078698
25MP0002060_abnormal_skin_morphology1.87630558
26MP0000377_abnormal_hair_follicle1.69839998
27MP0006054_spinal_hemorrhage1.62836533
28MP0010771_integument_phenotype1.58738381
29MP0005085_abnormal_gallbladder_physiolo1.57977665
30MP0003566_abnormal_cell_adhesion1.57553391
31MP0010155_abnormal_intestine_physiology1.57187123
32MP0000762_abnormal_tongue_morphology1.54960206
33MP0005381_digestive/alimentary_phenotyp1.54165959
34MP0001663_abnormal_digestive_system1.53742921
35MP0009053_abnormal_anal_canal1.52347847
36MP0005167_abnormal_blood-brain_barrier1.51496572
37MP0008875_abnormal_xenobiotic_pharmacok1.48901935
38MP0003868_abnormal_feces_composition1.47106917
39MP0003283_abnormal_digestive_organ1.46292529
40MP0005670_abnormal_white_adipose1.44057274
41MP0000427_abnormal_hair_cycle1.42297430
42MP0000477_abnormal_intestine_morphology1.41199743
43MP0001849_ear_inflammation1.41004168
44MP0002234_abnormal_pharynx_morphology1.40264186
45MP0000538_abnormal_urinary_bladder1.39377600
46MP0003315_abnormal_perineum_morphology1.38559857
47MP0001873_stomach_inflammation1.37880773
48MP0009840_abnormal_foam_cell1.36157504
49MP0003806_abnormal_nucleotide_metabolis1.35890507
50MP0003252_abnormal_bile_duct1.31967542
51MP0009780_abnormal_chondrocyte_physiolo1.30909169
52MP0004019_abnormal_vitamin_homeostasis1.29701111
53MP0001664_abnormal_digestion1.28705821
54MP0002138_abnormal_hepatobiliary_system1.24015444
55MP0004381_abnormal_hair_follicle1.22296476
56MP0003878_abnormal_ear_physiology1.19488786
57MP0005377_hearing/vestibular/ear_phenot1.19488786
58MP0005451_abnormal_body_composition1.18146283
59MP0010329_abnormal_lipoprotein_level1.17458264
60MP0005332_abnormal_amino_acid1.15854050
61MP0003300_gastrointestinal_ulcer1.15234399
62MP0000647_abnormal_sebaceous_gland1.13278003
63MP0003183_abnormal_peptide_metabolism1.12926228
64MP0004272_abnormal_basement_membrane1.11270866
65MP0009379_abnormal_foot_pigmentation1.09879743
66MP0003191_abnormal_cellular_cholesterol1.09434800
67MP0004185_abnormal_adipocyte_glucose1.09231875
68MP0000490_abnormal_crypts_of1.08651014
69MP0000516_abnormal_urinary_system1.07122550
70MP0005367_renal/urinary_system_phenotyp1.07122550
71MP0001958_emphysema1.06687930
72MP0005165_increased_susceptibility_to1.05615215
73MP0009931_abnormal_skin_appearance1.03060954
74MP0004858_abnormal_nervous_system1.02589667
75MP0010368_abnormal_lymphatic_system0.97628146
76MP0001191_abnormal_skin_condition0.97213828
77MP0005636_abnormal_mineral_homeostasis0.95184588
78MP0004147_increased_porphyrin_level0.93989216
79MP0009384_cardiac_valve_regurgitation0.93131351
80MP0005023_abnormal_wound_healing0.89843095
81MP0002822_catalepsy0.89434125
82MP0000566_synostosis0.88536028
83MP0004782_abnormal_surfactant_physiolog0.88386858
84MP0001756_abnormal_urination0.86178037
85MP0009643_abnormal_urine_homeostasis0.83964333
86MP0000230_abnormal_systemic_arterial0.81970934
87MP0004043_abnormal_pH_regulation0.81937780
88MP0005666_abnormal_adipose_tissue0.81093433
89MP0002139_abnormal_hepatobiliary_system0.81058463
90MP0002118_abnormal_lipid_homeostasis0.78764263
91MP0001346_abnormal_lacrimal_gland0.77258714
92MP0005257_abnormal_intraocular_pressure0.76923012
93MP0000470_abnormal_stomach_morphology0.76689984
94MP0002009_preneoplasia0.76656532
95MP0003045_fibrosis0.75557677
96MP0006138_congestive_heart_failure0.73752641
97MP0002877_abnormal_melanocyte_morpholog0.73575353
98MP0005084_abnormal_gallbladder_morpholo0.72806562
99MP0000249_abnormal_blood_vessel0.72178141
100MP0008004_abnormal_stomach_pH0.72033341
101MP0001765_abnormal_ion_homeostasis0.71522495
102MP0000367_abnormal_coat/_hair0.70739442
103MP0005083_abnormal_biliary_tract0.68561581
104MP0000678_abnormal_parathyroid_gland0.67569453
105MP0002166_altered_tumor_susceptibility0.65138668
106MP0004484_altered_response_of0.64480961
107MP0003638_abnormal_response/metabolism_0.64322130
108MP0001243_abnormal_dermal_layer0.64306466
109MP0001188_hyperpigmentation0.63706167
110MP0001881_abnormal_mammary_gland0.61865745
111MP0003718_maternal_effect0.61861147
112MP0005164_abnormal_response_to0.61793355
113MP0001764_abnormal_homeostasis0.61699621
114MP0005166_decreased_susceptibility_to0.60946212
115MP0003828_pulmonary_edema0.60758005
116MP0002089_abnormal_postnatal_growth/wei0.60755485
117MP0002896_abnormal_bone_mineralization0.59839136
118MP0000609_abnormal_liver_physiology0.59354364
119MP0003091_abnormal_cell_migration0.58912528
120MP0003724_increased_susceptibility_to0.58552395
121MP0002971_abnormal_brown_adipose0.58346212
122MP0002876_abnormal_thyroid_physiology0.57174948
123MP0005187_abnormal_penis_morphology0.56520329
124MP0000465_gastrointestinal_hemorrhage0.56046618
125MP0003950_abnormal_plasma_membrane0.55453432
126MP0005076_abnormal_cell_differentiation0.55364575
127MP0001879_abnormal_lymphatic_vessel0.53604284
128MP0002136_abnormal_kidney_physiology0.51797581
129MP0002282_abnormal_trachea_morphology0.50896903
130MP0000627_abnormal_mammary_gland0.50571073
131MP0005248_abnormal_Harderian_gland0.49572846
132MP0005310_abnormal_salivary_gland0.48895047
133MP0000613_abnormal_salivary_gland0.48137582

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.97742999
2Ileus (HP:0002595)5.15875324
3Fragile nails (HP:0001808)4.84361655
4Flat acetabular roof (HP:0003180)4.73670666
5Pili torti (HP:0003777)4.65909151
6Cupped ribs (HP:0000887)4.50459850
7Woolly hair (HP:0002224)4.48530200
8Milia (HP:0001056)4.46937154
9Plantar hyperkeratosis (HP:0007556)4.42921037
10Onycholysis (HP:0001806)4.34904429
11Decreased circulating renin level (HP:0003351)4.02149388
12Malnutrition (HP:0004395)3.61643409
13Abnormal tarsal ossification (HP:0008369)3.60617900
14Abnormality of renin-angiotensin system (HP:0000847)3.53394504
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.50267995
16Focal segmental glomerulosclerosis (HP:0000097)3.42064291
17Atrophic scars (HP:0001075)3.33964745
18Palmoplantar hyperkeratosis (HP:0000972)3.31341291
19Increased IgE level (HP:0003212)3.30013393
20Abnormality of proline metabolism (HP:0010907)3.23914440
21Hydroxyprolinuria (HP:0003080)3.23914440
22Mildly elevated creatine phosphokinase (HP:0008180)3.19563012
23Abdominal distention (HP:0003270)3.19101513
24Abnormality of the vitamin B12 metabolism (HP:0004341)3.17468415
25Confusion (HP:0001289)3.15279885
26Congenital ichthyosiform erythroderma (HP:0007431)3.09738850
27Curly hair (HP:0002212)3.08854964
28Palmar hyperkeratosis (HP:0010765)3.07452069
29Abnormality of nail color (HP:0100643)3.05123024
30Neonatal short-limb short stature (HP:0008921)3.04112214
31Alopecia of scalp (HP:0002293)3.00601169
32Hypotrichosis (HP:0001006)2.98050132
33Ventricular tachycardia (HP:0004756)2.97081474
34Interstitial pulmonary disease (HP:0006530)2.97005096
35Abnormality of vitamin B metabolism (HP:0004340)2.93365631
36Alkalosis (HP:0001948)2.87627953
37Pustule (HP:0200039)2.84776142
38Thin bony cortex (HP:0002753)2.82173709
39Abnormality of the 1st metacarpal (HP:0010009)2.81444735
40Glomerulosclerosis (HP:0000096)2.81366897
41Abnormal blistering of the skin (HP:0008066)2.76742796
42Hyperactive renin-angiotensin system (HP:0000841)2.76170116
43Abnormality of small intestinal villus morphology (HP:0011472)2.74170647
44Villous atrophy (HP:0011473)2.74170647
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73704127
46Autoimmune hemolytic anemia (HP:0001890)2.73523526
47Abnormality of carpal bone ossification (HP:0006257)2.69743466
48Systemic lupus erythematosus (HP:0002725)2.67700311
49Abnormal hair laboratory examination (HP:0003328)2.67316123
50Dehydration (HP:0001944)2.64896656
51Acanthocytosis (HP:0001927)2.62947225
52Nail dystrophy (HP:0008404)2.62402544
53Hyperuricemia (HP:0002149)2.62356316
54Increased purine levels (HP:0004368)2.62356316
55Abnormality of vitamin metabolism (HP:0100508)2.58706032
56Abnormality of the 2nd finger (HP:0004100)2.56766926
57Abnormal foot bone ossification (HP:0010675)2.56201536
58Thick nail (HP:0001805)2.53014976
59Abnormal glucose tolerance (HP:0001952)2.51546173
60Abnormality of the distal phalanx of the thumb (HP:0009617)2.51492929
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.51399207
62Osteolytic defects of the hand bones (HP:0009699)2.51399207
63Congenital sensorineural hearing impairment (HP:0008527)2.51224802
64Symphalangism affecting the phalanges of the hand (HP:0009773)2.51183100
65Abnormal vertebral ossification (HP:0100569)2.46671268
66Wide cranial sutures (HP:0010537)2.46072890
67Hyperaldosteronism (HP:0000859)2.45856427
68Irregular epiphyses (HP:0010582)2.44329852
69Vascular calcification (HP:0004934)2.43796160
70Distal lower limb muscle weakness (HP:0009053)2.41861536
71Autoimmune thrombocytopenia (HP:0001973)2.40858645
72Pterygium (HP:0001059)2.40506908
73Hypotension (HP:0002615)2.39580838
74Hemorrhage of the eye (HP:0011885)2.39096873
75Hoarse voice (HP:0001609)2.38794675
76Nephrolithiasis (HP:0000787)2.36336851
77Posterior subcapsular cataract (HP:0007787)2.35612079
78Hyperparathyroidism (HP:0000843)2.34743836
79Steatorrhea (HP:0002570)2.34177413
80Growth hormone excess (HP:0000845)2.32665405
81Rectal prolapse (HP:0002035)2.31904664
82Flattened epiphyses (HP:0003071)2.30271464
83Hypobetalipoproteinemia (HP:0003563)2.29947565
84Hyperphosphatemia (HP:0002905)2.28870927
85Chronic diarrhea (HP:0002028)2.25432473
86Cardiovascular calcification (HP:0011915)2.25382393
87Xanthomatosis (HP:0000991)2.24510268
88Hyporeflexia of lower limbs (HP:0002600)2.23970907
89Gout (HP:0001997)2.23351915
90Abnormality of purine metabolism (HP:0004352)2.23240091
91Abnormality of the gastric mucosa (HP:0004295)2.22801313
92Ridged nail (HP:0001807)2.21589730
93Flat capital femoral epiphysis (HP:0003370)2.20500782
94Subcapsular cataract (HP:0000523)2.20138392
95Widely patent fontanelles and sutures (HP:0004492)2.19759875
96Oral leukoplakia (HP:0002745)2.16592575
97Lip pit (HP:0100267)2.16301264
98Fragile skin (HP:0001030)2.16039647
99Myopathic facies (HP:0002058)2.15940514
100Glycosuria (HP:0003076)2.14046162
101Abnormality of urine glucose concentration (HP:0011016)2.14046162
102Aplasia cutis congenita (HP:0001057)2.14018227
103Conjugated hyperbilirubinemia (HP:0002908)2.10695838
104Syncope (HP:0001279)2.10219822
105Increased connective tissue (HP:0009025)2.10056647
106Hypoplasia of dental enamel (HP:0006297)2.09848515
107Pigmentary retinal degeneration (HP:0001146)2.08872430
108Mesangial abnormality (HP:0001966)2.08293105
109Abnormal hand bone ossification (HP:0010660)2.05143211
110Vertebral hypoplasia (HP:0008417)2.04401202
111Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04401202
112Progressive sensorineural hearing impairment (HP:0000408)2.04147520
113Proximal tubulopathy (HP:0000114)2.03854540
114Potter facies (HP:0002009)2.03047409
115Facial shape deformation (HP:0011334)2.03047409
116Hyponatremia (HP:0002902)2.02780354
117Metabolic alkalosis (HP:0200114)2.01019508
118Abnormality of chloride homeostasis (HP:0011422)2.00936174
119Parakeratosis (HP:0001036)2.00516908
120Abnormality of the distal phalanges of the toes (HP:0010182)2.00442860
121Acanthosis nigricans (HP:0000956)1.99650589
122Abnormal ossification of hand bones (HP:0005921)1.99467790
123Genu varum (HP:0002970)1.98658660
124Biliary tract neoplasm (HP:0100574)1.94735507
125Vertebral clefting (HP:0008428)1.94196868
126Axonal loss (HP:0003447)1.94116451
127Renal tubular acidosis (HP:0001947)1.94033360
128Hyperkalemia (HP:0002153)1.93352552
129Abnormality of the middle phalanges of the toes (HP:0010183)1.91986993
130Distal lower limb amyotrophy (HP:0008944)1.91699370
131Intrahepatic cholestasis (HP:0001406)1.90304726
132Enlarged epiphyses (HP:0010580)1.90101164
133Fat malabsorption (HP:0002630)1.89418924
134Gastrointestinal dysmotility (HP:0002579)1.88929307
135Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.88648452
136Palpitations (HP:0001962)1.88127848
137Ventricular fibrillation (HP:0001663)1.87802559
138Short hallux (HP:0010109)1.87515756
139Short phalanx of the thumb (HP:0009660)1.86875499
140Arterial tortuosity (HP:0005116)1.86396254
141Ureteral stenosis (HP:0000071)1.86268683
142Epiphyseal dysplasia (HP:0002656)1.85901729
143Abnormality of nucleobase metabolism (HP:0010932)1.82969882
144Progressive hearing impairment (HP:0001730)1.81754435
145Abnormal biliary tract morphology (HP:0012440)1.81506087
146Conjunctival hamartoma (HP:0100780)1.80977769
147Hip contracture (HP:0003273)1.80972040
148Multiple lipomas (HP:0001012)1.80756688
149Hypophosphatemia (HP:0002148)1.80547521
150Palmoplantar keratoderma (HP:0000982)1.79946202
151Polar cataract (HP:0010696)1.78882531
152Short middle phalanx of finger (HP:0005819)1.78155532
153Abnormality of the nasal mucosa (HP:0000433)1.77397648
154Abnormality of complement system (HP:0005339)1.76969395
155Ectropion (HP:0000656)1.74443063
156Ureteral obstruction (HP:0006000)1.73142614
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70867696
158Goiter (HP:0000853)1.70099524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.07000961
2FRK4.49281310
3MST1R4.48987970
4EPHB23.94031425
5RIPK13.87531223
6ACVR1B3.48272364
7EPHA22.87886273
8PIK3CA2.79431002
9MAP2K22.74425007
10LMTK22.70738021
11TAOK32.67299003
12MAP3K32.45400017
13PRKG22.27374401
14NME12.23490688
15MAP3K22.02418431
16STK391.97054266
17PTK61.96626889
18TAOK11.88815116
19FER1.86511233
20STK101.62351437
21DDR21.52873243
22AKT31.51731351
23MYLK1.51403617
24MAPKAPK31.51373858
25MET1.51096806
26TESK11.50567033
27ERN11.49462363
28LATS11.43994203
29GRK61.43734467
30PTK21.31008711
31TIE11.27327630
32IRAK31.14986628
33TRPM71.10996058
34EPHB11.05810841
35MAP2K11.03364398
36MAP3K11.02505830
37MAP3K141.00624206
38PRKCI0.99018577
39MATK0.94054761
40KSR20.90359661
41LRRK20.89779963
42MAP3K70.89567661
43TESK20.89066146
44DMPK0.85833890
45STK240.81343645
46NME20.78774144
47PIM20.78496200
48MAP3K100.77246810
49MAP3K110.76881377
50NLK0.75645810
51RIPK40.75102622
52SIK10.73580840
53OXSR10.72274156
54PDK20.69986886
55ABL20.68598364
56PRKAA20.67535660
57GRK10.66947189
58ERBB30.66926176
59TTN0.66662195
60BMX0.66090536
61STK38L0.65945130
62LIMK10.65441739
63MAP3K90.62143006
64NUAK10.62128394
65ERBB20.60895222
66PAK40.57090574
67MAP3K80.57031082
68RPS6KB20.55781948
69MAP2K60.55078190
70TNIK0.52065591
71KDR0.47942990
72MELK0.47438565
73MAPK150.46998165
74TGFBR20.46736417
75PIK3CG0.45832935
76STK110.45269366
77WNK40.44624375
78ILK0.44411969
79CAMK2D0.44239382
80DYRK1B0.43730045
81ROCK10.42727818
82SRC0.42676189
83GSK3A0.42503514
84MAPKAPK20.42375791
85STK30.42225176
86CDK80.40790615
87ICK0.40489486
88TBK10.38407491
89PAK20.35670453
90BCR0.35496284
91PRKD10.35059618
92MAP2K30.33963301
93CSK0.33835588
94ITK0.33460510
95STK380.33113464
96EPHA30.33113192
97TRIB30.32294953
98PDGFRB0.30954466
99IRAK10.30708777
100CDK60.29964162
101PDPK10.29497621
102MAP3K60.29209930
103MAP3K120.28533148
104PRKCA0.26835147
105ARAF0.26702583
106NTRK10.26676713
107ERBB40.26661509
108MAPK110.25091848
109PAK30.24741652
110FGFR30.24572864
111EEF2K0.23997008
112CAMK2G0.23666200
113FGFR10.23205606
114PRKCE0.22959654
115EPHA40.22793184
116CDK90.22642186
117IGF1R0.22302162
118PTK2B0.22211645
119RET0.22056937
120PRKCD0.21868151
121ZAP700.21760026
122CHUK0.21710104
123RPS6KA10.21318729
124FGFR40.20224718
125TLK10.19999788
126PDGFRA0.19881346
127PBK0.18982894
128PRKAA10.18934901
129PRKACG0.17942506
130CDC42BPA0.17919016
131PHKG20.16670849
132PHKG10.16670849

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.64792155
2Mineral absorption_Homo sapiens_hsa049783.95594116
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.53120456
4Sulfur metabolism_Homo sapiens_hsa009203.40831007
5Renin-angiotensin system_Homo sapiens_hsa046143.13765329
6Vitamin digestion and absorption_Homo sapiens_hsa049772.63531333
7Caffeine metabolism_Homo sapiens_hsa002322.52077699
8Protein digestion and absorption_Homo sapiens_hsa049742.30682866
9Bile secretion_Homo sapiens_hsa049762.28921055
10Galactose metabolism_Homo sapiens_hsa000521.98530453
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97252202
12Histidine metabolism_Homo sapiens_hsa003401.95914276
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.83210832
14Sphingolipid metabolism_Homo sapiens_hsa006001.81183421
15Starch and sucrose metabolism_Homo sapiens_hsa005001.75936252
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64316374
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61838389
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55080300
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46367746
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45496715
21Tight junction_Homo sapiens_hsa045301.41567430
22Linoleic acid metabolism_Homo sapiens_hsa005911.33191311
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31891981
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.31791993
25Fructose and mannose metabolism_Homo sapiens_hsa000511.28494485
26Glutathione metabolism_Homo sapiens_hsa004801.27056466
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26672128
28PPAR signaling pathway_Homo sapiens_hsa033201.21030837
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20682785
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.19324095
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18369428
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18257422
33Chemical carcinogenesis_Homo sapiens_hsa052041.09250908
34Adherens junction_Homo sapiens_hsa045201.08329603
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06647774
36Pancreatic secretion_Homo sapiens_hsa049721.02540797
37ECM-receptor interaction_Homo sapiens_hsa045121.00974717
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.00697736
39Folate biosynthesis_Homo sapiens_hsa007900.98799250
40Arachidonic acid metabolism_Homo sapiens_hsa005900.98047711
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97130110
42Glycerolipid metabolism_Homo sapiens_hsa005610.91317459
43Retinol metabolism_Homo sapiens_hsa008300.88242677
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83556257
45Tryptophan metabolism_Homo sapiens_hsa003800.83195330
46Thyroid hormone synthesis_Homo sapiens_hsa049180.81722059
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78059326
48Nitrogen metabolism_Homo sapiens_hsa009100.77670328
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75754010
50Bladder cancer_Homo sapiens_hsa052190.75450408
51Salmonella infection_Homo sapiens_hsa051320.74969699
52Fatty acid degradation_Homo sapiens_hsa000710.73491834
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.72927614
54Salivary secretion_Homo sapiens_hsa049700.69291322
55Hepatitis C_Homo sapiens_hsa051600.65557363
56Amoebiasis_Homo sapiens_hsa051460.63935569
57Thyroid cancer_Homo sapiens_hsa052160.62827211
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62494169
59Gastric acid secretion_Homo sapiens_hsa049710.62247659
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60278452
61Sulfur relay system_Homo sapiens_hsa041220.58634170
62Arginine biosynthesis_Homo sapiens_hsa002200.58231566
63ABC transporters_Homo sapiens_hsa020100.58046121
64Ether lipid metabolism_Homo sapiens_hsa005650.57633792
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.57181485
66Asthma_Homo sapiens_hsa053100.56893710
67Phenylalanine metabolism_Homo sapiens_hsa003600.54647942
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52765399
69Arginine and proline metabolism_Homo sapiens_hsa003300.52222053
70Tyrosine metabolism_Homo sapiens_hsa003500.48074106
71VEGF signaling pathway_Homo sapiens_hsa043700.48070456
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47332013
73Toxoplasmosis_Homo sapiens_hsa051450.46139664
74Renin secretion_Homo sapiens_hsa049240.45086064
75Proteoglycans in cancer_Homo sapiens_hsa052050.43439489
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42261997
77Pertussis_Homo sapiens_hsa051330.41728192
78Hematopoietic cell lineage_Homo sapiens_hsa046400.41504590
79GnRH signaling pathway_Homo sapiens_hsa049120.39637358
80Focal adhesion_Homo sapiens_hsa045100.39408103
81Hippo signaling pathway_Homo sapiens_hsa043900.38315760
82TNF signaling pathway_Homo sapiens_hsa046680.38131088
83beta-Alanine metabolism_Homo sapiens_hsa004100.37214650
84African trypanosomiasis_Homo sapiens_hsa051430.36939557
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36757136
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.36168020
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36157146
88Small cell lung cancer_Homo sapiens_hsa052220.35312028
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33264261
90Dorso-ventral axis formation_Homo sapiens_hsa043200.29866833
91Other glycan degradation_Homo sapiens_hsa005110.29619139
92Ovarian steroidogenesis_Homo sapiens_hsa049130.28573950
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28416249
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.25380250
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.25281070
96Axon guidance_Homo sapiens_hsa043600.24873207
97Vibrio cholerae infection_Homo sapiens_hsa051100.23665371
98Peroxisome_Homo sapiens_hsa041460.23455240
99Fatty acid biosynthesis_Homo sapiens_hsa000610.23241134
100Insulin resistance_Homo sapiens_hsa049310.22887707
101Basal cell carcinoma_Homo sapiens_hsa052170.22721287
102Metabolic pathways_Homo sapiens_hsa011000.21867833
103HIF-1 signaling pathway_Homo sapiens_hsa040660.21860524
104TGF-beta signaling pathway_Homo sapiens_hsa043500.21536933
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21400070
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20542271
107Choline metabolism in cancer_Homo sapiens_hsa052310.20467817
108Autoimmune thyroid disease_Homo sapiens_hsa053200.20435167
109Fatty acid elongation_Homo sapiens_hsa000620.20338704
110Platelet activation_Homo sapiens_hsa046110.19285732
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19268885
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18842580
113Pentose phosphate pathway_Homo sapiens_hsa000300.18640378
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.18321400
115Allograft rejection_Homo sapiens_hsa053300.16610130
116Pyruvate metabolism_Homo sapiens_hsa006200.13362589
117Glucagon signaling pathway_Homo sapiens_hsa049220.13239465
118Fatty acid metabolism_Homo sapiens_hsa012120.13022530
119Staphylococcus aureus infection_Homo sapiens_hsa051500.11749823
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10584231
121Graft-versus-host disease_Homo sapiens_hsa053320.09585391
122Shigellosis_Homo sapiens_hsa051310.08949365
123N-Glycan biosynthesis_Homo sapiens_hsa005100.08937592
124Endocytosis_Homo sapiens_hsa041440.07851633

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