MAK16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.60909298
2nucleobase biosynthetic process (GO:0046112)4.52114238
3maturation of SSU-rRNA (GO:0030490)4.49127145
4purine nucleobase biosynthetic process (GO:0009113)4.34759954
5DNA replication initiation (GO:0006270)4.34195703
6mitotic metaphase plate congression (GO:0007080)4.33823724
7nuclear pore organization (GO:0006999)4.31357715
8ribosome biogenesis (GO:0042254)4.25963555
9DNA strand elongation involved in DNA replication (GO:0006271)4.19776566
10nuclear pore complex assembly (GO:0051292)4.13056442
11DNA unwinding involved in DNA replication (GO:0006268)4.12585370
12DNA replication checkpoint (GO:0000076)4.08264960
13ribosome assembly (GO:0042255)4.07904753
14ribosomal small subunit assembly (GO:0000028)4.05797082
15DNA double-strand break processing (GO:0000729)4.04051384
16protein localization to kinetochore (GO:0034501)4.02105063
17DNA strand elongation (GO:0022616)4.00145668
18ribonucleoprotein complex biogenesis (GO:0022613)4.00105501
19mitotic nuclear envelope disassembly (GO:0007077)3.97684735
20ribosomal large subunit biogenesis (GO:0042273)3.96809129
21IMP biosynthetic process (GO:0006188)3.96370608
22telomere maintenance via semi-conservative replication (GO:0032201)3.85542223
23non-recombinational repair (GO:0000726)3.79608362
24double-strand break repair via nonhomologous end joining (GO:0006303)3.79608362
25mitotic sister chromatid cohesion (GO:0007064)3.75600629
26CENP-A containing nucleosome assembly (GO:0034080)3.75282528
27metaphase plate congression (GO:0051310)3.74322039
28chromatin remodeling at centromere (GO:0031055)3.73994363
29folic acid-containing compound biosynthetic process (GO:0009396)3.69138666
30membrane disassembly (GO:0030397)3.67878540
31nuclear envelope disassembly (GO:0051081)3.67878540
32DNA replication-dependent nucleosome organization (GO:0034723)3.66031699
33DNA replication-dependent nucleosome assembly (GO:0006335)3.66031699
34rRNA processing (GO:0006364)3.65289171
35somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.65015330
36somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.65015330
37isotype switching (GO:0045190)3.65015330
38cullin deneddylation (GO:0010388)3.64057300
39regulation of centriole replication (GO:0046599)3.63734597
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62988744
41regulation of mitotic spindle checkpoint (GO:1903504)3.62988744
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.60521289
43IMP metabolic process (GO:0046040)3.58187529
44mitotic spindle checkpoint (GO:0071174)3.58027021
45translational termination (GO:0006415)3.56624626
46viral transcription (GO:0019083)3.55861710
47telomere maintenance via recombination (GO:0000722)3.55455114
48kinetochore organization (GO:0051383)3.55157797
49rRNA metabolic process (GO:0016072)3.53936212
50ribosomal small subunit biogenesis (GO:0042274)3.53560825
51protein localization to chromosome, centromeric region (GO:0071459)3.51907296
52spliceosomal snRNP assembly (GO:0000387)3.46756349
53somatic recombination of immunoglobulin gene segments (GO:0016447)3.45637563
54translational initiation (GO:0006413)3.44878666
55mitotic recombination (GO:0006312)3.44250205
56protein deneddylation (GO:0000338)3.42899790
57DNA catabolic process, exonucleolytic (GO:0000738)3.42823727
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.41898052
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.41898052
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.41898052
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.41898052
62negative regulation of sister chromatid segregation (GO:0033046)3.41898052
63maturation of 5.8S rRNA (GO:0000460)3.39586369
64negative regulation of chromosome segregation (GO:0051985)3.39300591
65DNA replication-independent nucleosome assembly (GO:0006336)3.37435376
66DNA replication-independent nucleosome organization (GO:0034724)3.37435376
67establishment of viral latency (GO:0019043)3.36327555
68tRNA aminoacylation for protein translation (GO:0006418)3.35467055
69establishment of chromosome localization (GO:0051303)3.35116069
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35056853
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35056853
72rRNA methylation (GO:0031167)3.34945007
73tRNA aminoacylation (GO:0043039)3.34638560
74amino acid activation (GO:0043038)3.34638560
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34468255
76telomere maintenance via telomerase (GO:0007004)3.34260274
77DNA deamination (GO:0045006)3.32894479
78telomere maintenance via telomere lengthening (GO:0010833)3.30773956
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29569134
80negative regulation of ligase activity (GO:0051352)3.29569134
81sister chromatid segregation (GO:0000819)3.29003651
82translational elongation (GO:0006414)3.27349686
83regulation of spindle organization (GO:0090224)3.27144589
84pore complex assembly (GO:0046931)3.24811289
85replication fork processing (GO:0031297)3.22676664
86regulation of helicase activity (GO:0051095)3.20456437
87regulation of sister chromatid segregation (GO:0033045)3.20420662
88regulation of mitotic sister chromatid separation (GO:0010965)3.20420662
89regulation of mitotic sister chromatid segregation (GO:0033047)3.20420662
90regulation of chromosome segregation (GO:0051983)3.18736799
91L-serine metabolic process (GO:0006563)3.18274192
92kinetochore assembly (GO:0051382)3.17605341
93rRNA modification (GO:0000154)3.17237859
94transcription from mitochondrial promoter (GO:0006390)3.17096772
95histone exchange (GO:0043486)3.16661734
96mitotic spindle assembly checkpoint (GO:0007094)3.16527684
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16494921
98pseudouridine synthesis (GO:0001522)3.15448257
99RNA-dependent DNA replication (GO:0006278)3.13962111
100transcription-coupled nucleotide-excision repair (GO:0006283)3.13294108
101attachment of spindle microtubules to kinetochore (GO:0008608)3.13225416
102spindle assembly checkpoint (GO:0071173)3.11694446
103establishment of integrated proviral latency (GO:0075713)3.11692795
104transcription elongation from RNA polymerase III promoter (GO:0006385)3.10440428
105termination of RNA polymerase III transcription (GO:0006386)3.10440428
106establishment of protein localization to mitochondrial membrane (GO:0090151)3.09386882
107somatic hypermutation of immunoglobulin genes (GO:0016446)3.08663426
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08663426
109nucleotide-excision repair, DNA gap filling (GO:0006297)3.06298017
110transcription elongation from RNA polymerase I promoter (GO:0006362)3.06021512
111termination of RNA polymerase I transcription (GO:0006363)3.05445402
112DNA duplex unwinding (GO:0032508)3.05422889
113DNA geometric change (GO:0032392)3.05297796
114mitotic sister chromatid segregation (GO:0000070)3.05096469
115response to X-ray (GO:0010165)3.04937735
116somatic diversification of immunoglobulins (GO:0016445)3.04806988
117proteasome assembly (GO:0043248)3.03096536
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02609793
119positive regulation of chromosome segregation (GO:0051984)2.98874182
120transcription from RNA polymerase I promoter (GO:0006360)2.98787640
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96195998
122mitotic chromosome condensation (GO:0007076)2.95519755
123cotranslational protein targeting to membrane (GO:0006613)2.95002249
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94821092
125spliceosomal complex assembly (GO:0000245)2.93668148
126protein targeting to ER (GO:0045047)2.93554061
1277-methylguanosine mRNA capping (GO:0006370)2.92461053
128regulation of translation in response to stress (GO:0043555)2.92294120
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92119464
130RNA splicing, via transesterification reactions (GO:0000375)2.91860062
131G1/S transition of mitotic cell cycle (GO:0000082)2.90603485
132cell cycle G1/S phase transition (GO:0044843)2.90603485
133cellular component biogenesis (GO:0044085)2.90356193
134RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89609715
135mRNA splicing, via spliceosome (GO:0000398)2.89609715
136RNA capping (GO:0036260)2.89308225
1377-methylguanosine RNA capping (GO:0009452)2.89308225
138regulation of mitotic spindle organization (GO:0060236)2.89005384
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88045719
140cellular protein complex disassembly (GO:0043624)2.87926360
141meiotic chromosome segregation (GO:0045132)2.87373326
142spindle checkpoint (GO:0031577)2.86255981
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85640146
144DNA-templated transcription, termination (GO:0006353)2.83118837
145protein K6-linked ubiquitination (GO:0085020)2.82649043
146regulation of gene silencing by miRNA (GO:0060964)2.82486700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14885998
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56746118
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.69542570
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67450226
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49157838
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25644088
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24953300
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10414278
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01560881
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.01367569
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99124863
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.85818020
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85581692
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85332665
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69491882
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52673199
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50409165
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41347764
19XRN2_22483619_ChIP-Seq_HELA_Human2.38962382
20VDR_23849224_ChIP-Seq_CD4+_Human2.37001114
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19769351
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19013441
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06080094
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05861855
25AR_21909140_ChIP-Seq_LNCAP_Human2.05253055
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.03643631
27FOXP3_21729870_ChIP-Seq_TREG_Human2.02960977
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01560355
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01014064
30ELK1_19687146_ChIP-ChIP_HELA_Human1.98603922
31DCP1A_22483619_ChIP-Seq_HELA_Human1.97054512
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95405849
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94457350
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.89549375
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85816351
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85681674
37TTF2_22483619_ChIP-Seq_HELA_Human1.83539181
38* GABP_19822575_ChIP-Seq_HepG2_Human1.82112963
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78497258
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77428916
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74626194
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73774698
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72297981
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70765158
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60439322
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54057433
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51863017
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50440795
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49295253
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48104784
51EWS_26573619_Chip-Seq_HEK293_Human1.48028477
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.47030673
53KDM5A_27292631_Chip-Seq_BREAST_Human1.42801053
54MYC_22102868_ChIP-Seq_BL_Human1.42109180
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41176254
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39831585
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39695866
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37808307
59CIITA_25753668_ChIP-Seq_RAJI_Human1.36008578
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35633093
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.35420942
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.34898675
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32762323
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.30932874
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28401974
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28258537
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27937392
68TFEB_21752829_ChIP-Seq_HELA_Human1.25958978
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25077043
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24525893
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.23590175
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22542989
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21754236
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.21044033
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18265546
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18093082
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16900099
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14636431
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.14351251
80FUS_26573619_Chip-Seq_HEK293_Human1.14131264
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11125055
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11125055
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11125055
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09671655
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08617997
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08105527
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07202386
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06736470
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06165102
90* ELK1_22589737_ChIP-Seq_MCF10A_Human1.04329327
91MYC_18940864_ChIP-ChIP_HL60_Human1.02533318
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.02257771
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01287927
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98883932
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98590275
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98368848
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98110552
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96912344
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96420462
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95160197
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95142220
102ZNF274_21170338_ChIP-Seq_K562_Hela0.94755848
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93709878
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.91927437
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90262422
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89956606
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89837414
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89454633
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88677090
110SPI1_23547873_ChIP-Seq_NB4_Human0.88669020
111VDR_22108803_ChIP-Seq_LS180_Human0.86060638
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85514058
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83560796
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81784657
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81763680
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78251317
117ELF5_23300383_ChIP-Seq_T47D_Human0.77350593
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76555504
119P300_19829295_ChIP-Seq_ESCs_Human0.71396596
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70269078
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70156503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.42673019
2MP0004957_abnormal_blastocyst_morpholog4.68317342
3MP0010094_abnormal_chromosome_stability4.49929499
4MP0003111_abnormal_nucleus_morphology4.27205020
5MP0008057_abnormal_DNA_replication4.06096161
6MP0003077_abnormal_cell_cycle4.03481230
7MP0008058_abnormal_DNA_repair3.47493236
8MP0008007_abnormal_cellular_replicative2.99740689
9MP0008932_abnormal_embryonic_tissue2.76217420
10MP0001730_embryonic_growth_arrest2.48026548
11MP0003123_paternal_imprinting2.47024297
12MP0002396_abnormal_hematopoietic_system2.40400878
13MP0000350_abnormal_cell_proliferation2.38169737
14MP0010352_gastrointestinal_tract_polyps2.26503442
15MP0009697_abnormal_copulation2.07238176
16MP0003786_premature_aging2.04719934
17MP0010307_abnormal_tumor_latency2.02498350
18MP0008877_abnormal_DNA_methylation1.95256436
19MP0002254_reproductive_system_inflammat1.86697439
20MP0002102_abnormal_ear_morphology1.83842942
21MP0001697_abnormal_embryo_size1.79098045
22MP0001672_abnormal_embryogenesis/_devel1.78784915
23MP0005380_embryogenesis_phenotype1.78784915
24MP0003718_maternal_effect1.68972281
25MP0006072_abnormal_retinal_apoptosis1.60889530
26MP0000490_abnormal_crypts_of1.60040864
27MP0003984_embryonic_growth_retardation1.59207390
28MP0002080_prenatal_lethality1.58978243
29MP0003806_abnormal_nucleotide_metabolis1.57248302
30MP0002088_abnormal_embryonic_growth/wei1.55792318
31MP0009333_abnormal_splenocyte_physiolog1.55188779
32MP0002085_abnormal_embryonic_tissue1.55161109
33MP0002084_abnormal_developmental_patter1.53215232
34MP0004197_abnormal_fetal_growth/weight/1.52920239
35MP0000313_abnormal_cell_death1.47317629
36MP0002019_abnormal_tumor_incidence1.45277043
37MP0002086_abnormal_extraembryonic_tissu1.43371473
38MP0003950_abnormal_plasma_membrane1.39752347
39MP0004808_abnormal_hematopoietic_stem1.37979566
40MP0003890_abnormal_embryonic-extraembry1.36135115
41MP0003763_abnormal_thymus_physiology1.35422191
42MP0001293_anophthalmia1.34303600
43MP0006035_abnormal_mitochondrial_morpho1.32793099
44MP0006292_abnormal_olfactory_placode1.28076246
45MP0000372_irregular_coat_pigmentation1.24655842
46MP0003121_genomic_imprinting1.24284574
47MP0010030_abnormal_orbit_morphology1.23129985
48MP0002938_white_spotting1.21935417
49MP0005076_abnormal_cell_differentiation1.19692070
50MP0000703_abnormal_thymus_morphology1.18557360
51MP0006036_abnormal_mitochondrial_physio1.14302470
52MP0002398_abnormal_bone_marrow1.12856044
53MP0005408_hypopigmentation1.11615794
54MP0002210_abnormal_sex_determination1.11057889
55MP0004133_heterotaxia1.10893849
56MP0002722_abnormal_immune_system1.08302182
57MP0003315_abnormal_perineum_morphology1.07390071
58MP0000689_abnormal_spleen_morphology1.04357207
59MP0003567_abnormal_fetal_cardiomyocyte1.03917351
60MP0005395_other_phenotype1.00923196
61MP0002233_abnormal_nose_morphology0.98505964
62MP0000858_altered_metastatic_potential0.97398567
63MP0001145_abnormal_male_reproductive0.95651370
64MP0000537_abnormal_urethra_morphology0.93662652
65MP0001188_hyperpigmentation0.93459550
66MP0003186_abnormal_redox_activity0.91028251
67MP0001661_extended_life_span0.89471342
68MP0003941_abnormal_skin_development0.88346303
69MP0003937_abnormal_limbs/digits/tail_de0.87755310
70MP0000358_abnormal_cell_content/0.87094316
71MP0005671_abnormal_response_to0.86247710
72MP0002429_abnormal_blood_cell0.85979832
73MP0002653_abnormal_ependyma_morphology0.85827371
74MP0005384_cellular_phenotype0.85485476
75MP0005023_abnormal_wound_healing0.84758500
76MP0002111_abnormal_tail_morphology0.84732220
77MP0005621_abnormal_cell_physiology0.84410053
78MP0003943_abnormal_hepatobiliary_system0.83706716
79MP0002160_abnormal_reproductive_system0.83520424
80MP0001529_abnormal_vocalization0.82387413
81MP0005397_hematopoietic_system_phenotyp0.82369138
82MP0001545_abnormal_hematopoietic_system0.82369138
83MP0002132_abnormal_respiratory_system0.81871660
84MP0002090_abnormal_vision0.81741847
85MP0001929_abnormal_gametogenesis0.80900739
86MP0000653_abnormal_sex_gland0.80485820
87MP0002751_abnormal_autonomic_nervous0.80345691
88MP0003448_altered_tumor_morphology0.80072048
89MP0004215_abnormal_myocardial_fiber0.76691080
90MP0000716_abnormal_immune_system0.76470163
91MP0002697_abnormal_eye_size0.75871785
92MP0001119_abnormal_female_reproductive0.75308280
93MP0003119_abnormal_digestive_system0.75287740
94MP0005253_abnormal_eye_physiology0.75032737
95MP0003566_abnormal_cell_adhesion0.74401538
96MP0010234_abnormal_vibrissa_follicle0.74198105
97MP0009672_abnormal_birth_weight0.73383962
98MP0000749_muscle_degeneration0.71967249
99MP0001286_abnormal_eye_development0.71561256
100MP0001800_abnormal_humoral_immune0.70898602
101MP0003136_yellow_coat_color0.70867399
102MP0001853_heart_inflammation0.69035548
103MP0005389_reproductive_system_phenotype0.68366235
104MP0006054_spinal_hemorrhage0.68078160
105MP0009053_abnormal_anal_canal0.67574742
106MP0001177_atelectasis0.67281129
107MP0002092_abnormal_eye_morphology0.65676305
108MP0000428_abnormal_craniofacial_morphol0.64760870
109MP0002060_abnormal_skin_morphology0.64648069
110MP0004233_abnormal_muscle_weight0.64605507
111MP0003195_calcinosis0.64129011
112MP0002405_respiratory_system_inflammati0.63831323
113MP0000432_abnormal_head_morphology0.63307746
114MP0001915_intracranial_hemorrhage0.63246130
115MP0002420_abnormal_adaptive_immunity0.62852313
116MP0003755_abnormal_palate_morphology0.62296544
117MP0009703_decreased_birth_body0.62133860
118MP0002452_abnormal_antigen_presenting0.61960622
119MP0000647_abnormal_sebaceous_gland0.61944666
120MP0000477_abnormal_intestine_morphology0.61732910
121MP0003935_abnormal_craniofacial_develop0.61613506
122MP0001819_abnormal_immune_cell0.61543475
123MP0005367_renal/urinary_system_phenotyp0.59389170
124MP0000516_abnormal_urinary_system0.59389170
125MP0009250_abnormal_appendicular_skeleto0.59087257
126MP0003221_abnormal_cardiomyocyte_apopto0.58941529
127MP0005501_abnormal_skin_physiology0.58741520
128MP0000613_abnormal_salivary_gland0.58352150
129MP0003936_abnormal_reproductive_system0.57541011
130MP0003646_muscle_fatigue0.57330049
131MP0001835_abnormal_antigen_presentation0.56195110
132MP0000627_abnormal_mammary_gland0.55960168
133MP0001849_ear_inflammation0.55332232
134MP0002006_tumorigenesis0.55275779
135MP0005391_vision/eye_phenotype0.53479673
136MP0001881_abnormal_mammary_gland0.52657622
137MP0001243_abnormal_dermal_layer0.52631070
138MP0002877_abnormal_melanocyte_morpholog0.51920795

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.03540186
2Breast hypoplasia (HP:0003187)4.01793288
3Reticulocytopenia (HP:0001896)3.85636980
4Carpal bone hypoplasia (HP:0001498)3.60861993
5Abnormality of cells of the erythroid lineage (HP:0012130)3.56225352
6Abnormality of the anterior horn cell (HP:0006802)3.46280662
7Degeneration of anterior horn cells (HP:0002398)3.46280662
8Oral leukoplakia (HP:0002745)3.42079566
9Agnosia (HP:0010524)3.38263180
10Chromsome breakage (HP:0040012)3.38127956
11Selective tooth agenesis (HP:0001592)3.36785751
12Abnormality of methionine metabolism (HP:0010901)3.32233283
13Patellar aplasia (HP:0006443)3.28665493
14Abnormal number of erythroid precursors (HP:0012131)3.20109297
15Abnormality of the labia minora (HP:0012880)3.17017149
16Medulloblastoma (HP:0002885)3.16338323
17Cerebral hypomyelination (HP:0006808)3.14851581
18Rough bone trabeculation (HP:0100670)3.13291404
19Colon cancer (HP:0003003)3.10797370
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09578728
21Abnormality of chromosome stability (HP:0003220)3.08549467
22Aplasia/Hypoplasia of the patella (HP:0006498)3.08095321
23Nephroblastoma (Wilms tumor) (HP:0002667)3.06622978
24Ependymoma (HP:0002888)3.05704063
25Abnormality of the preputium (HP:0100587)3.03433148
26Embryonal renal neoplasm (HP:0011794)2.96955048
27Meckel diverticulum (HP:0002245)2.95281350
28Aplastic anemia (HP:0001915)2.86263234
29Abnormality of glycolysis (HP:0004366)2.83708693
30Absent radius (HP:0003974)2.82882514
31Abnormality of the ileum (HP:0001549)2.77563482
32Absent thumb (HP:0009777)2.76247469
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.75607044
34Premature graying of hair (HP:0002216)2.74013514
35Short middle phalanx of the 5th finger (HP:0004220)2.68387443
36Macrocytic anemia (HP:0001972)2.68094030
37Supernumerary spleens (HP:0009799)2.66794156
38Absent forearm bone (HP:0003953)2.63614642
39Aplasia involving forearm bones (HP:0009822)2.63614642
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.63410333
41Rhabdomyosarcoma (HP:0002859)2.61206744
42Increased serum pyruvate (HP:0003542)2.60386898
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58051953
44Neoplasm of the adrenal gland (HP:0100631)2.57434124
45Myelodysplasia (HP:0002863)2.57060663
46Volvulus (HP:0002580)2.54763214
47Trismus (HP:0000211)2.52878485
48Neoplasm of the pancreas (HP:0002894)2.47545504
49Abnormality of serum amino acid levels (HP:0003112)2.47336843
5011 pairs of ribs (HP:0000878)2.41583222
51Pallor (HP:0000980)2.38553566
52Impulsivity (HP:0100710)2.36735220
53Basal cell carcinoma (HP:0002671)2.36225018
54Abnormal trabecular bone morphology (HP:0100671)2.34624184
55Duodenal stenosis (HP:0100867)2.32142891
56Small intestinal stenosis (HP:0012848)2.32142891
57Acute encephalopathy (HP:0006846)2.31298592
58Squamous cell carcinoma (HP:0002860)2.30649399
59Glossoptosis (HP:0000162)2.28783743
60Abnormal lung lobation (HP:0002101)2.28144604
61Horseshoe kidney (HP:0000085)2.27005881
62Bone marrow hypocellularity (HP:0005528)2.26665864
63Amaurosis fugax (HP:0100576)2.26201764
64Abnormal number of incisors (HP:0011064)2.25775829
65Neoplasm of the colon (HP:0100273)2.24145356
66Acute necrotizing encephalopathy (HP:0006965)2.21364863
67Deviation of the thumb (HP:0009603)2.20864379
68Microretrognathia (HP:0000308)2.19777858
69Proximal placement of thumb (HP:0009623)2.18850017
70Lymphoma (HP:0002665)2.18279956
71Sloping forehead (HP:0000340)2.17858523
72Ectopic kidney (HP:0000086)2.16557949
73Amniotic constriction ring (HP:0009775)2.16373345
74Abnormality of placental membranes (HP:0011409)2.16373345
75Cellular immunodeficiency (HP:0005374)2.16036355
76Sensory axonal neuropathy (HP:0003390)2.14935502
77Triphalangeal thumb (HP:0001199)2.14797219
78Tracheoesophageal fistula (HP:0002575)2.14796583
79Stenosis of the external auditory canal (HP:0000402)2.12806721
80Neoplasm of the adrenal cortex (HP:0100641)2.12595638
81Increased hepatocellular lipid droplets (HP:0006565)2.12004313
82Breast carcinoma (HP:0003002)2.10348173
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09673148
84Abnormality of alanine metabolism (HP:0010916)2.09673148
85Hyperalaninemia (HP:0003348)2.09673148
86Increased CSF lactate (HP:0002490)2.08917950
87Pancreatic islet-cell hyperplasia (HP:0004510)2.08777759
88Multiple enchondromatosis (HP:0005701)2.08103992
89Atresia of the external auditory canal (HP:0000413)2.04515814
90Megaloblastic anemia (HP:0001889)2.03320495
91Increased serum lactate (HP:0002151)2.01081467
92Secondary amenorrhea (HP:0000869)2.00319670
93Abnormality of the carotid arteries (HP:0005344)1.97890128
94Premature ovarian failure (HP:0008209)1.96529234
95Progressive macrocephaly (HP:0004481)1.96346194
96Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96343266
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.95357718
98Abnormality of the duodenum (HP:0002246)1.94603490
99Methylmalonic acidemia (HP:0002912)1.94338806
100Abnormality of sulfur amino acid metabolism (HP:0004339)1.93550936
101Aplasia/hypoplasia of the humerus (HP:0006507)1.93073050
102Abnormalities of placenta or umbilical cord (HP:0001194)1.92859985
103Abnormality of DNA repair (HP:0003254)1.92799658
104Increased nuchal translucency (HP:0010880)1.92414577
105Missing ribs (HP:0000921)1.92009258
106Type I transferrin isoform profile (HP:0003642)1.91651839
107Spastic diplegia (HP:0001264)1.91270598
108Thrombocytosis (HP:0001894)1.90757392
109Hypoplastic pelvis (HP:0008839)1.90648804
110CNS hypomyelination (HP:0003429)1.89761467
111Irregular epiphyses (HP:0010582)1.89285746
112Hypoplasia of the pons (HP:0012110)1.88867088
113Reduced antithrombin III activity (HP:0001976)1.88230445
114Clubbing of toes (HP:0100760)1.87517471
115Abnormality of the astrocytes (HP:0100707)1.87480899
116Astrocytoma (HP:0009592)1.87480899
117Neoplasm of the oral cavity (HP:0100649)1.87471851
118Uterine neoplasm (HP:0010784)1.87274577
119Cleft eyelid (HP:0000625)1.87062480
120Homocystinuria (HP:0002156)1.86013750
121Abnormality of homocysteine metabolism (HP:0010919)1.86013750
122Progressive external ophthalmoplegia (HP:0000590)1.85670942
123Abnormality of the pons (HP:0007361)1.85234280
124Abnormal mitochondria in muscle tissue (HP:0008316)1.84814154
125Cerebral edema (HP:0002181)1.84646540
126Ovarian neoplasm (HP:0100615)1.84447028
127Acute myeloid leukemia (HP:0004808)1.84177827
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82595998
129Glioma (HP:0009733)1.81677919
130Small hand (HP:0200055)1.80844307
131Cortical dysplasia (HP:0002539)1.80688559
132Short thumb (HP:0009778)1.79257430
133Lipid accumulation in hepatocytes (HP:0006561)1.79153186
134Facial hemangioma (HP:0000329)1.78963781
135Abdominal situs inversus (HP:0003363)1.78011667
136Abnormality of abdominal situs (HP:0011620)1.78011667
137Hyperglycinemia (HP:0002154)1.77663269
138Muscle fiber atrophy (HP:0100295)1.76936921
139Rib fusion (HP:0000902)1.76873318
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.75464349
141Neoplasm of the small intestine (HP:0100833)1.75413859
142Slender long bone (HP:0003100)1.75403640
143Abnormality of the umbilical cord (HP:0010881)1.75015199
144Hypoplasia of the radius (HP:0002984)1.74224119
145Choanal atresia (HP:0000453)1.73990050
146Prominent nose (HP:0000448)1.73365248
147Entropion (HP:0000621)1.72437447
148Asplenia (HP:0001746)1.72381855
149Adenoma sebaceum (HP:0009720)1.72070409
150Angiofibromas (HP:0010615)1.72070409
151Pancytopenia (HP:0001876)1.71820670
152Primitive neuroectodermal tumor (HP:0030065)1.71234213
153Neuroblastic tumors (HP:0004376)1.71234213
154Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.71234213
155Biliary tract neoplasm (HP:0100574)1.70531053
156Neoplasm of striated muscle (HP:0009728)1.70175351
157Postnatal microcephaly (HP:0005484)1.68510554
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67941819
159Duplicated collecting system (HP:0000081)1.67211950
160Cafe-au-lait spot (HP:0000957)1.66810477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.14539231
2WEE14.09045019
3EIF2AK13.92663423
4CDC73.90204528
5TRIM283.39204129
6SRPK12.83052839
7EIF2AK32.74061980
8BRSK22.60967231
9TSSK62.57635426
10NME22.52087346
11NEK22.32063580
12MKNK12.12193921
13ACVR1B2.10500289
14TLK12.09763463
15NUAK12.05683831
16TTK2.02205553
17TAF12.01432553
18VRK21.98799317
19CDK121.96273756
20PLK31.92297635
21PLK11.91825878
22PLK41.91221235
23PASK1.75609646
24VRK11.72591723
25NEK11.71323356
26CDK71.69892810
27TESK21.67589314
28MKNK21.67487295
29EPHA21.67000835
30AURKB1.64378997
31ATR1.56406337
32RPS6KB21.52135119
33STK101.50035030
34TNIK1.46693823
35RPS6KA41.45143573
36CHEK21.43097854
37DYRK31.40305727
38PDK21.39805370
39BRSK11.32442629
40MAP3K81.29919832
41CHEK11.28379218
42BMPR1B1.27871091
43WNK31.26725714
44AURKA1.21883616
45PBK1.20796936
46TGFBR11.18430161
47STK161.17398625
48CDK41.14651653
49MST41.11171729
50ERBB31.06641546
51LATS11.01716158
52PIM20.99840179
53PIM10.99100079
54BCR0.97448044
55SIK30.96779011
56BRD40.95944936
57EIF2AK20.95524405
58STK40.95142271
59ZAK0.94654218
60SCYL20.94123603
61ATM0.90190446
62ALK0.89929666
63PNCK0.89015177
64PLK20.87475416
65ERBB40.86342672
66STK390.83850430
67CDK20.82627468
68TESK10.82536826
69TIE10.81869498
70CSNK2A20.80491276
71PAK40.78726839
72LIMK10.77890565
73MAP4K10.76487243
74FRK0.75983591
75FLT30.75942992
76MARK30.73898921
77NLK0.72335948
78CSNK1G10.69871086
79MELK0.68571411
80CSNK2A10.67682277
81STK240.66257226
82CDK60.65605819
83NME10.65200514
84CCNB10.63963962
85CDK80.60955934
86STK30.60776502
87STK38L0.60661094
88CDK10.60313745
89PAK10.59158700
90TXK0.57866500
91OXSR10.57165440
92RPS6KA50.56269852
93TEC0.53278027
94PRKCI0.52618709
95LRRK20.50325643
96CDK190.49495610
97MAP4K20.46994312
98EEF2K0.45516835
99MAP2K30.41899473
100KDR0.39773718
101GRK10.39143647
102CSNK1E0.38194656
103MAP3K110.37719065
104MAP3K120.36794204
105ZAP700.36473882
106DAPK10.36214642
107TAOK20.36141714
108DYRK20.35221528
109BRAF0.34547042
110JAK30.33958841
111FGFR10.33691689
112MAP3K100.33233443
113PRKDC0.32304898
114IKBKB0.31949315
115BTK0.31490876
116SMG10.29700957
117CSNK1A1L0.29604974
118CSNK1G30.29295545
119LATS20.28566132
120CLK10.27938700
121CDK90.26797585
122ITK0.25994201
123CAMK1G0.25821228
124CSNK1G20.24561163
125PAK20.24453055
126CSNK1D0.21885119
127YES10.21561960
128MAPK140.21272325
129GRK60.20902665
130MAPKAPK20.20627875
131MTOR0.20050421
132MAPKAPK50.14740574
133FER0.14502170

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34091874
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.20810655
3Mismatch repair_Homo sapiens_hsa034303.91634200
4RNA polymerase_Homo sapiens_hsa030203.66858714
5Ribosome_Homo sapiens_hsa030103.42229345
6Spliceosome_Homo sapiens_hsa030403.38679532
7Proteasome_Homo sapiens_hsa030503.35752008
8RNA transport_Homo sapiens_hsa030133.30461882
9Homologous recombination_Homo sapiens_hsa034402.89621324
10Nucleotide excision repair_Homo sapiens_hsa034202.89607958
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70918025
12Base excision repair_Homo sapiens_hsa034102.59945334
13One carbon pool by folate_Homo sapiens_hsa006702.56701290
14Cell cycle_Homo sapiens_hsa041102.55579133
15Pyrimidine metabolism_Homo sapiens_hsa002402.41553623
16Basal transcription factors_Homo sapiens_hsa030222.24563752
17Non-homologous end-joining_Homo sapiens_hsa034502.19703035
18Fanconi anemia pathway_Homo sapiens_hsa034602.14465840
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01401529
20RNA degradation_Homo sapiens_hsa030181.99207061
21Propanoate metabolism_Homo sapiens_hsa006401.81643255
22mRNA surveillance pathway_Homo sapiens_hsa030151.73463855
23p53 signaling pathway_Homo sapiens_hsa041151.67959175
24Pyruvate metabolism_Homo sapiens_hsa006201.45428221
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43006843
26Epstein-Barr virus infection_Homo sapiens_hsa051691.38017405
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35678204
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34978974
29Purine metabolism_Homo sapiens_hsa002301.30968051
30Systemic lupus erythematosus_Homo sapiens_hsa053221.25089461
31Steroid biosynthesis_Homo sapiens_hsa001001.23981516
32Antigen processing and presentation_Homo sapiens_hsa046121.16285996
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13254984
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12943145
35Viral carcinogenesis_Homo sapiens_hsa052031.07036323
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06317986
37Herpes simplex infection_Homo sapiens_hsa051681.00519229
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97062949
39Protein export_Homo sapiens_hsa030600.94983834
40Fatty acid elongation_Homo sapiens_hsa000620.92187541
41Oxidative phosphorylation_Homo sapiens_hsa001900.91478330
42Sulfur metabolism_Homo sapiens_hsa009200.89475746
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89392074
44Primary immunodeficiency_Homo sapiens_hsa053400.84440090
45Oocyte meiosis_Homo sapiens_hsa041140.80431962
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79914458
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77312225
48HTLV-I infection_Homo sapiens_hsa051660.76167295
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.67590396
50Vitamin B6 metabolism_Homo sapiens_hsa007500.67274991
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.66652910
52Thyroid cancer_Homo sapiens_hsa052160.66547621
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66490016
54Folate biosynthesis_Homo sapiens_hsa007900.63327856
55Legionellosis_Homo sapiens_hsa051340.62966548
56Biosynthesis of amino acids_Homo sapiens_hsa012300.61872173
57MicroRNAs in cancer_Homo sapiens_hsa052060.61313964
58Pentose phosphate pathway_Homo sapiens_hsa000300.59884458
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.56577382
60Measles_Homo sapiens_hsa051620.56008808
61Selenocompound metabolism_Homo sapiens_hsa004500.54526269
62Small cell lung cancer_Homo sapiens_hsa052220.53496305
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53273636
64TGF-beta signaling pathway_Homo sapiens_hsa043500.52404374
65Sulfur relay system_Homo sapiens_hsa041220.51188812
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49307531
67Shigellosis_Homo sapiens_hsa051310.48215271
68Apoptosis_Homo sapiens_hsa042100.47504916
69Hematopoietic cell lineage_Homo sapiens_hsa046400.46960074
70Huntingtons disease_Homo sapiens_hsa050160.46736968
71Allograft rejection_Homo sapiens_hsa053300.45665503
72Lysine degradation_Homo sapiens_hsa003100.45259633
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44480045
74Arginine and proline metabolism_Homo sapiens_hsa003300.44240376
75Alcoholism_Homo sapiens_hsa050340.43899415
76Graft-versus-host disease_Homo sapiens_hsa053320.42910324
77Fatty acid metabolism_Homo sapiens_hsa012120.42703568
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40357554
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.40208519
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39848399
81Alzheimers disease_Homo sapiens_hsa050100.37900490
82Hippo signaling pathway_Homo sapiens_hsa043900.37521156
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36307621
84Glutathione metabolism_Homo sapiens_hsa004800.33160268
85Asthma_Homo sapiens_hsa053100.32888919
86Wnt signaling pathway_Homo sapiens_hsa043100.32795727
87Colorectal cancer_Homo sapiens_hsa052100.32140249
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31841177
89Hepatitis B_Homo sapiens_hsa051610.31243758
90Fatty acid degradation_Homo sapiens_hsa000710.30864440
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.30850347
92Bladder cancer_Homo sapiens_hsa052190.29003132
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28728077
94beta-Alanine metabolism_Homo sapiens_hsa004100.27853630
95Butanoate metabolism_Homo sapiens_hsa006500.27595571
96Influenza A_Homo sapiens_hsa051640.26818768
97Basal cell carcinoma_Homo sapiens_hsa052170.26654402
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26428981
99Type I diabetes mellitus_Homo sapiens_hsa049400.26075345
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25248366
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24606364
102HIF-1 signaling pathway_Homo sapiens_hsa040660.24115524
103T cell receptor signaling pathway_Homo sapiens_hsa046600.23791864
104Pathways in cancer_Homo sapiens_hsa052000.23668132
105Viral myocarditis_Homo sapiens_hsa054160.23518834
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23291461
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23167659
108N-Glycan biosynthesis_Homo sapiens_hsa005100.22754972
109Tryptophan metabolism_Homo sapiens_hsa003800.22723901
110Vitamin digestion and absorption_Homo sapiens_hsa049770.22688571
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22407091
112Parkinsons disease_Homo sapiens_hsa050120.22308453
113Caffeine metabolism_Homo sapiens_hsa002320.21231043
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21057873
115Autoimmune thyroid disease_Homo sapiens_hsa053200.21048144
116Peroxisome_Homo sapiens_hsa041460.21022342
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20340996
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20057069
119Notch signaling pathway_Homo sapiens_hsa043300.19152391
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18797718
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18241622
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17206189
123Melanoma_Homo sapiens_hsa052180.16328742
124Tight junction_Homo sapiens_hsa045300.15543771
125Adherens junction_Homo sapiens_hsa045200.15374893
126Carbon metabolism_Homo sapiens_hsa012000.14985439
127Chronic myeloid leukemia_Homo sapiens_hsa052200.14360625
128Acute myeloid leukemia_Homo sapiens_hsa052210.14171278
129Prostate cancer_Homo sapiens_hsa052150.13627810
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12752670
131Renin-angiotensin system_Homo sapiens_hsa046140.12717879
132Leishmaniasis_Homo sapiens_hsa051400.12377632
133Metabolic pathways_Homo sapiens_hsa011000.11552985
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11106231
135Hedgehog signaling pathway_Homo sapiens_hsa043400.07947578
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07894082
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.04944585

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