MAGOH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.54258355
2viral transcription (GO:0019083)5.46785597
3translational termination (GO:0006415)5.37754169
4ribosomal small subunit biogenesis (GO:0042274)5.37442918
5maturation of SSU-rRNA (GO:0030490)5.24285197
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84970303
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64963650
8translational elongation (GO:0006414)4.64650252
9cotranslational protein targeting to membrane (GO:0006613)4.56402956
10ribosomal large subunit biogenesis (GO:0042273)4.54706158
11protein targeting to ER (GO:0045047)4.53373321
12translational initiation (GO:0006413)4.49688687
13mitotic metaphase plate congression (GO:0007080)4.46985299
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.44183072
15* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.34674926
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33340418
17ATP synthesis coupled proton transport (GO:0015986)4.33340418
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.31300775
19protein localization to endoplasmic reticulum (GO:0070972)4.28675447
20DNA deamination (GO:0045006)4.26904132
21cellular protein complex disassembly (GO:0043624)4.21875694
22viral life cycle (GO:0019058)4.21365648
23CENP-A containing nucleosome assembly (GO:0034080)4.17320129
24DNA replication checkpoint (GO:0000076)4.16851486
25ribonucleoprotein complex biogenesis (GO:0022613)4.14630301
26DNA strand elongation involved in DNA replication (GO:0006271)4.10644496
27chaperone-mediated protein transport (GO:0072321)4.09426592
28chromatin remodeling at centromere (GO:0031055)4.07473435
29formation of translation preinitiation complex (GO:0001731)3.96124534
30telomere maintenance via semi-conservative replication (GO:0032201)3.94751652
31DNA replication initiation (GO:0006270)3.92858718
32kinetochore organization (GO:0051383)3.92178427
33DNA strand elongation (GO:0022616)3.90519483
34proteasome assembly (GO:0043248)3.84568830
35kinetochore assembly (GO:0051382)3.84064639
36metaphase plate congression (GO:0051310)3.81223801
37protein localization to kinetochore (GO:0034501)3.80221814
38rRNA processing (GO:0006364)3.74430703
39DNA replication-independent nucleosome organization (GO:0034724)3.74377172
40DNA replication-independent nucleosome assembly (GO:0006336)3.74377172
41protein complex disassembly (GO:0043241)3.74359669
42telomere maintenance via recombination (GO:0000722)3.68670069
43spliceosomal snRNP assembly (GO:0000387)3.68268375
44regulation of mitochondrial translation (GO:0070129)3.67221294
45termination of RNA polymerase III transcription (GO:0006386)3.66642160
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.66642160
47translation (GO:0006412)3.63190590
48rRNA metabolic process (GO:0016072)3.61139394
49nucleobase biosynthetic process (GO:0046112)3.61027553
50purine nucleobase biosynthetic process (GO:0009113)3.58461834
51ribosome biogenesis (GO:0042254)3.56035355
527-methylguanosine mRNA capping (GO:0006370)3.55793918
53rRNA modification (GO:0000154)3.54988935
54macromolecular complex disassembly (GO:0032984)3.54142929
557-methylguanosine RNA capping (GO:0009452)3.51759061
56RNA capping (GO:0036260)3.51759061
57ribosome assembly (GO:0042255)3.50820844
58spliceosomal complex assembly (GO:0000245)3.50725857
59mitotic recombination (GO:0006312)3.49684129
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48303758
61* nuclear-transcribed mRNA catabolic process (GO:0000956)3.46896136
62histone exchange (GO:0043486)3.46116866
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45007250
64respiratory electron transport chain (GO:0022904)3.42778497
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42278948
66attachment of spindle microtubules to kinetochore (GO:0008608)3.39882407
67protein localization to chromosome, centromeric region (GO:0071459)3.39719111
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39396424
69transcription-coupled nucleotide-excision repair (GO:0006283)3.38524548
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36921491
71establishment of chromosome localization (GO:0051303)3.35751013
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34698951
73electron transport chain (GO:0022900)3.32316644
74* mRNA catabolic process (GO:0006402)3.30661546
75establishment of integrated proviral latency (GO:0075713)3.25558000
76cellular component biogenesis (GO:0044085)3.23872000
77DNA replication-dependent nucleosome assembly (GO:0006335)3.21681067
78DNA replication-dependent nucleosome organization (GO:0034723)3.21681067
79termination of RNA polymerase I transcription (GO:0006363)3.21081197
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19647533
81* termination of RNA polymerase II transcription (GO:0006369)3.19145805
82telomere maintenance via telomere lengthening (GO:0010833)3.18952473
83transcription elongation from RNA polymerase I promoter (GO:0006362)3.17762994
84maturation of 5.8S rRNA (GO:0000460)3.17273301
85* RNA catabolic process (GO:0006401)3.16773223
86mitotic nuclear envelope disassembly (GO:0007077)3.16278678
87DNA unwinding involved in DNA replication (GO:0006268)3.14389714
88negative regulation of ligase activity (GO:0051352)3.13432055
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13432055
90positive regulation of ligase activity (GO:0051351)3.10696658
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09600779
92negative regulation of RNA splicing (GO:0033119)3.08860446
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.08490094
94mitochondrial respiratory chain complex assembly (GO:0033108)3.07934236
95IMP biosynthetic process (GO:0006188)3.07718205
96protein targeting to mitochondrion (GO:0006626)3.06334450
97transcription from RNA polymerase I promoter (GO:0006360)3.04855996
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04368569
99mitochondrial respiratory chain complex I assembly (GO:0032981)3.04368569
100NADH dehydrogenase complex assembly (GO:0010257)3.04368569
101signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04268914
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03870457
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03870457
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03870457
105sister chromatid segregation (GO:0000819)3.01554809
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.00990690
107signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00990690
108pseudouridine synthesis (GO:0001522)3.00060142
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99851608
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99547817
111regulation of ubiquitin-protein transferase activity (GO:0051438)2.99531595
112transcription elongation from RNA polymerase II promoter (GO:0006368)2.99411716
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98225400
114cell cycle G1/S phase transition (GO:0044843)2.97538722
115G1/S transition of mitotic cell cycle (GO:0000082)2.97538722
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.97236981
117mitotic sister chromatid segregation (GO:0000070)2.96765389
118mitotic chromosome condensation (GO:0007076)2.96424625
119spindle checkpoint (GO:0031577)2.95934251
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94545122
121protein targeting to membrane (GO:0006612)2.92699382
122histone mRNA metabolic process (GO:0008334)2.91328820
123regulation of spindle organization (GO:0090224)2.90735427
124nuclear envelope disassembly (GO:0051081)2.90264587
125membrane disassembly (GO:0030397)2.90264587
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90067966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.45333057
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54290767
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89322599
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.76392714
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.67227137
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64266213
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.57893281
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48173559
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36019771
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.19833645
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17923375
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16983948
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06846663
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94602455
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94361904
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92368733
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88922030
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78252010
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72461704
20* XRN2_22483619_ChIP-Seq_HELA_Human2.57244796
21VDR_23849224_ChIP-Seq_CD4+_Human2.53275393
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42020947
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28000867
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27147021
25DCP1A_22483619_ChIP-Seq_HELA_Human2.20429279
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18111514
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13804005
28FOXP3_21729870_ChIP-Seq_TREG_Human2.12442131
29AR_21909140_ChIP-Seq_LNCAP_Human2.10520817
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09013143
31TTF2_22483619_ChIP-Seq_HELA_Human2.07643653
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03950747
33* ELK1_19687146_ChIP-ChIP_HELA_Human2.02053803
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01524255
35* GABP_19822575_ChIP-Seq_HepG2_Human1.94606168
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85644878
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.81186952
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80762229
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80212642
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78622182
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78366600
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75169794
43* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68352498
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68099873
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64578369
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.57641842
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.54133339
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52208594
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51872532
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50054102
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48054719
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46773883
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46332660
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.41631116
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36782320
56KDM5A_27292631_Chip-Seq_BREAST_Human1.35053274
57CIITA_25753668_ChIP-Seq_RAJI_Human1.32923821
58MYC_18940864_ChIP-ChIP_HL60_Human1.29705994
59* ELK1_22589737_ChIP-Seq_MCF10A_Human1.28465241
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28298188
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26668430
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26522727
63* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22829868
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20890478
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20143757
66* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17407142
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16966449
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16531442
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16415458
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15620518
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.13189737
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11479127
73* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10684116
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08115120
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06552930
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05856926
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01570945
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99864617
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99562331
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99020015
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97949412
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95766851
83* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95396868
84TFEB_21752829_ChIP-Seq_HELA_Human0.94267543
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94017811
86EGR1_19374776_ChIP-ChIP_THP-1_Human0.91812723
87MYC_22102868_ChIP-Seq_BL_Human0.91654140
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90867014
89SPI1_23547873_ChIP-Seq_NB4_Human0.90056992
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89478659
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84018733
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83609762
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83113215
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81979522
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81558957
96IRF1_19129219_ChIP-ChIP_H3396_Human0.79133101
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.78022484
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.77764091
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77608489
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.75788285
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75155741
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75010277
103* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74863804
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73383158
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72402031
106* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72141028
107* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71312439
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.70941738
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70431142
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69981921
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67617080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.89257885
2MP0004957_abnormal_blastocyst_morpholog4.51760740
3MP0010094_abnormal_chromosome_stability4.27148898
4MP0003111_abnormal_nucleus_morphology4.10210970
5* MP0003077_abnormal_cell_cycle3.85503805
6MP0008057_abnormal_DNA_replication3.57557192
7MP0008058_abnormal_DNA_repair3.17567667
8MP0008007_abnormal_cellular_replicative2.91501761
9MP0008932_abnormal_embryonic_tissue2.79556802
10MP0003123_paternal_imprinting2.43667741
11MP0003718_maternal_effect2.41120772
12MP0009697_abnormal_copulation2.38858807
13MP0003786_premature_aging2.35196829
14MP0009379_abnormal_foot_pigmentation2.34638660
15MP0006292_abnormal_olfactory_placode2.20326547
16MP0001730_embryonic_growth_arrest2.01199837
17MP0000350_abnormal_cell_proliferation1.98137261
18MP0008877_abnormal_DNA_methylation1.94602933
19MP0002396_abnormal_hematopoietic_system1.74867962
20MP0002102_abnormal_ear_morphology1.74061079
21MP0000490_abnormal_crypts_of1.66837588
22MP0003315_abnormal_perineum_morphology1.63091737
23MP0003136_yellow_coat_color1.62433311
24MP0006035_abnormal_mitochondrial_morpho1.55522171
25MP0005499_abnormal_olfactory_system1.54150000
26MP0005394_taste/olfaction_phenotype1.54150000
27MP0009333_abnormal_splenocyte_physiolog1.54001019
28MP0010030_abnormal_orbit_morphology1.53785981
29MP0001697_abnormal_embryo_size1.52160073
30MP0005380_embryogenesis_phenotype1.44175601
31MP0001672_abnormal_embryogenesis/_devel1.44175601
32MP0002085_abnormal_embryonic_tissue1.37940185
33MP0000313_abnormal_cell_death1.31865870
34* MP0002080_prenatal_lethality1.31000356
35MP0002210_abnormal_sex_determination1.30608122
36MP0002019_abnormal_tumor_incidence1.28892577
37MP0010307_abnormal_tumor_latency1.25691703
38MP0002163_abnormal_gland_morphology1.24948824
39MP0003121_genomic_imprinting1.24188860
40MP0003567_abnormal_fetal_cardiomyocyte1.23541557
41MP0003984_embryonic_growth_retardation1.21571314
42MP0006082_CNS_inflammation1.20984531
43MP0003941_abnormal_skin_development1.19588951
44MP0002088_abnormal_embryonic_growth/wei1.19392737
45MP0002938_white_spotting1.19276146
46MP0003186_abnormal_redox_activity1.16248265
47MP0002084_abnormal_developmental_patter1.16208737
48MP0002132_abnormal_respiratory_system1.13023500
49MP0003763_abnormal_thymus_physiology1.11813644
50MP0003890_abnormal_embryonic-extraembry1.11715475
51MP0001145_abnormal_male_reproductive1.10480747
52MP0004808_abnormal_hematopoietic_stem1.07786454
53MP0003937_abnormal_limbs/digits/tail_de1.06125630
54MP0000653_abnormal_sex_gland1.04722389
55MP0001119_abnormal_female_reproductive1.04087909
56MP0000566_synostosis1.02499270
57MP0002086_abnormal_extraembryonic_tissu1.02410347
58MP0001929_abnormal_gametogenesis1.00251331
59MP0001293_anophthalmia1.00208756
60MP0010352_gastrointestinal_tract_polyps0.98674167
61MP0001881_abnormal_mammary_gland0.97779009
62MP0004197_abnormal_fetal_growth/weight/0.95297883
63MP0001873_stomach_inflammation0.93509482
64MP0002160_abnormal_reproductive_system0.91223832
65MP0000703_abnormal_thymus_morphology0.90754714
66MP0008995_early_reproductive_senescence0.89338423
67MP0008789_abnormal_olfactory_epithelium0.86619699
68MP0005397_hematopoietic_system_phenotyp0.86612982
69MP0001545_abnormal_hematopoietic_system0.86612982
70MP0005451_abnormal_body_composition0.86460866
71MP0002233_abnormal_nose_morphology0.86438932
72MP0006072_abnormal_retinal_apoptosis0.86179388
73MP0002398_abnormal_bone_marrow0.85632889
74MP0005389_reproductive_system_phenotype0.84699807
75MP0000858_altered_metastatic_potential0.84375409
76MP0001529_abnormal_vocalization0.83352063
77MP0002697_abnormal_eye_size0.82875450
78MP0002722_abnormal_immune_system0.81931802
79MP0002234_abnormal_pharynx_morphology0.81121440
80MP0001286_abnormal_eye_development0.81114626
81MP0003806_abnormal_nucleotide_metabolis0.80050425
82MP0003938_abnormal_ear_development0.78062858
83MP0004381_abnormal_hair_follicle0.77786228
84MP0002277_abnormal_respiratory_mucosa0.77613172
85MP0009053_abnormal_anal_canal0.77319687
86MP0003119_abnormal_digestive_system0.75804814
87MP0002111_abnormal_tail_morphology0.75785128
88MP0000689_abnormal_spleen_morphology0.75038811
89MP0002095_abnormal_skin_pigmentation0.73961265
90MP0001764_abnormal_homeostasis0.71649708
91MP0006054_spinal_hemorrhage0.69230087
92MP0001919_abnormal_reproductive_system0.69210672
93MP0005395_other_phenotype0.68367848
94MP0001727_abnormal_embryo_implantation0.68307552
95MP0002653_abnormal_ependyma_morphology0.67880294
96MP0000358_abnormal_cell_content/0.67766027
97MP0002638_abnormal_pupillary_reflex0.67297638
98MP0002429_abnormal_blood_cell0.66750759
99MP0005501_abnormal_skin_physiology0.65085124
100MP0002161_abnormal_fertility/fecundity0.64862979
101MP0005647_abnormal_sex_gland0.64580196
102MP0000049_abnormal_middle_ear0.63731629
103MP0001853_heart_inflammation0.61340545
104MP0003221_abnormal_cardiomyocyte_apopto0.61264129
105MP0000372_irregular_coat_pigmentation0.60438621
106MP0004133_heterotaxia0.59785045
107MP0005384_cellular_phenotype0.59367163
108MP0005319_abnormal_enzyme/_coenzyme0.59256341
109MP0000383_abnormal_hair_follicle0.59084225
110MP0006036_abnormal_mitochondrial_physio0.58595514
111MP0003699_abnormal_female_reproductive0.58367264
112MP0002751_abnormal_autonomic_nervous0.57656942
113MP0000716_abnormal_immune_system0.56100335
114MP0000537_abnormal_urethra_morphology0.55760307
115MP0002405_respiratory_system_inflammati0.55527788
116MP0003755_abnormal_palate_morphology0.54853116
117MP0005076_abnormal_cell_differentiation0.54116329
118MP0005671_abnormal_response_to0.52714441
119MP0005379_endocrine/exocrine_gland_phen0.52222447
120MP0002092_abnormal_eye_morphology0.51380937
121MP0005410_abnormal_fertilization0.49660065
122MP0005084_abnormal_gallbladder_morpholo0.49373153
123MP0003698_abnormal_male_reproductive0.49324029
124MP0000678_abnormal_parathyroid_gland0.48121218
125MP0008873_increased_physiological_sensi0.48021992

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.94966848
2Reticulocytopenia (HP:0001896)5.50070075
3Abnormal number of erythroid precursors (HP:0012131)5.38099316
4Birth length less than 3rd percentile (HP:0003561)4.91730436
5Breast hypoplasia (HP:0003187)4.08684867
6Macrocytic anemia (HP:0001972)4.04297093
7Carpal bone hypoplasia (HP:0001498)3.68292920
8Pallor (HP:0000980)3.67382541
9Cerebral edema (HP:0002181)3.54449625
10Patellar aplasia (HP:0006443)3.51380526
11Oral leukoplakia (HP:0002745)3.38757762
12Hepatic necrosis (HP:0002605)3.36369206
13Aplastic anemia (HP:0001915)3.34384832
14Aplasia/Hypoplasia of the patella (HP:0006498)3.33840558
15Chromsome breakage (HP:0040012)3.26219568
16Rough bone trabeculation (HP:0100670)3.10819064
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10453673
18Renal Fanconi syndrome (HP:0001994)3.06496953
19Colon cancer (HP:0003003)2.96564432
20Microvesicular hepatic steatosis (HP:0001414)2.96241287
21Meckel diverticulum (HP:0002245)2.92380948
22Abnormality of the preputium (HP:0100587)2.90716948
23Increased serum pyruvate (HP:0003542)2.87644199
24Increased intramyocellular lipid droplets (HP:0012240)2.86352280
25Absent thumb (HP:0009777)2.82321643
26Lactic acidosis (HP:0003128)2.80061954
27Megaloblastic anemia (HP:0001889)2.78054462
28Exercise intolerance (HP:0003546)2.76807482
29Abnormality of the ileum (HP:0001549)2.76477849
30Abnormality of chromosome stability (HP:0003220)2.75314553
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70003401
32Abnormality of glycolysis (HP:0004366)2.64067028
33Secondary amenorrhea (HP:0000869)2.62131866
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60576966
35Cerebral hypomyelination (HP:0006808)2.59276234
36Respiratory failure (HP:0002878)2.58940670
37Absent radius (HP:0003974)2.58375858
38Multiple enchondromatosis (HP:0005701)2.58341502
39Leukodystrophy (HP:0002415)2.55856593
4011 pairs of ribs (HP:0000878)2.54574238
41Abnormality of the anterior horn cell (HP:0006802)2.52692307
42Degeneration of anterior horn cells (HP:0002398)2.52692307
43Microretrognathia (HP:0000308)2.52162714
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.51568951
45Increased hepatocellular lipid droplets (HP:0006565)2.49776238
46Premature graying of hair (HP:0002216)2.47827166
47Selective tooth agenesis (HP:0001592)2.45512202
48Myelodysplasia (HP:0002863)2.44690494
49Triphalangeal thumb (HP:0001199)2.43014487
50Congenital, generalized hypertrichosis (HP:0004540)2.40675152
51Absent forearm bone (HP:0003953)2.40353413
52Aplasia involving forearm bones (HP:0009822)2.40353413
53Trismus (HP:0000211)2.39262813
54Acute necrotizing encephalopathy (HP:0006965)2.39021675
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37992687
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37992687
57Horseshoe kidney (HP:0000085)2.35191968
58Increased muscle lipid content (HP:0009058)2.33266502
59Abnormal lung lobation (HP:0002101)2.32964637
60Abnormal trabecular bone morphology (HP:0100671)2.32809107
61Premature ovarian failure (HP:0008209)2.31418890
62Small intestinal stenosis (HP:0012848)2.29437167
63Duodenal stenosis (HP:0100867)2.29437167
64Exertional dyspnea (HP:0002875)2.27672651
65Supernumerary spleens (HP:0009799)2.27093600
66Cleft eyelid (HP:0000625)2.25701636
67Bone marrow hypocellularity (HP:0005528)2.25230543
68Neoplasm of the pancreas (HP:0002894)2.18795961
69Mitochondrial inheritance (HP:0001427)2.18337603
70Progressive muscle weakness (HP:0003323)2.17104371
71Cellular immunodeficiency (HP:0005374)2.15521705
72Medulloblastoma (HP:0002885)2.15265633
73Facial hemangioma (HP:0000329)2.14855443
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13232316
75Atresia of the external auditory canal (HP:0000413)2.13213769
76Abnormality of the labia minora (HP:0012880)2.12913220
77Lipid accumulation in hepatocytes (HP:0006561)2.09405058
78Optic disc pallor (HP:0000543)2.08268097
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08050633
80Hypoplasia of the radius (HP:0002984)2.07019321
81Abnormal number of incisors (HP:0011064)2.06518142
82Septo-optic dysplasia (HP:0100842)2.05483584
83Impulsivity (HP:0100710)2.04041595
84Glossoptosis (HP:0000162)2.03623560
85Stenosis of the external auditory canal (HP:0000402)2.03519454
86Sparse eyelashes (HP:0000653)2.02542337
87Increased CSF lactate (HP:0002490)2.01335160
88Tracheoesophageal fistula (HP:0002575)2.01155643
89Abnormal mitochondria in muscle tissue (HP:0008316)2.00904473
90Thrombocytosis (HP:0001894)2.00678325
91Respiratory difficulties (HP:0002880)1.98329673
92Short thumb (HP:0009778)1.97510133
93Duplicated collecting system (HP:0000081)1.97007649
94Abnormality of pyrimidine metabolism (HP:0004353)1.95887025
95Testicular atrophy (HP:0000029)1.94886339
96Squamous cell carcinoma (HP:0002860)1.91471453
97Irregular epiphyses (HP:0010582)1.90300439
98Depressed nasal ridge (HP:0000457)1.89956940
99Abnormality of reticulocytes (HP:0004312)1.89797331
1003-Methylglutaconic aciduria (HP:0003535)1.88561136
101Hepatocellular necrosis (HP:0001404)1.87520184
102Lethargy (HP:0001254)1.87456934
103Ragged-red muscle fibers (HP:0003200)1.86547601
104Type I transferrin isoform profile (HP:0003642)1.86310343
105Agnosia (HP:0010524)1.85212121
106Abnormality of the duodenum (HP:0002246)1.84736563
107Hyperglycinemia (HP:0002154)1.83244965
108Pancytopenia (HP:0001876)1.83211254
109Rhabdomyosarcoma (HP:0002859)1.83024587
110Progressive macrocephaly (HP:0004481)1.82824651
111Abnormality of methionine metabolism (HP:0010901)1.82624403
112Sloping forehead (HP:0000340)1.82532425
113Aplasia/hypoplasia of the uterus (HP:0008684)1.82164117
114Abnormality of renal resorption (HP:0011038)1.81789945
115Absent septum pellucidum (HP:0001331)1.81699419
116Increased serum lactate (HP:0002151)1.79804135
117Gout (HP:0001997)1.78990678
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76123505
119Abnormal spermatogenesis (HP:0008669)1.75363010
120Amniotic constriction ring (HP:0009775)1.74618583
121Abnormality of placental membranes (HP:0011409)1.74618583
122Nausea (HP:0002018)1.73128635
123Abnormality of the septum pellucidum (HP:0007375)1.71614890
124Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71401583
125Short middle phalanx of the 5th finger (HP:0004220)1.70369942
126Acute encephalopathy (HP:0006846)1.69568771
127Abnormal gallbladder physiology (HP:0012438)1.69038216
128Cholecystitis (HP:0001082)1.69038216
129Missing ribs (HP:0000921)1.68870039
130Hypoplastic pelvis (HP:0008839)1.68755550
131Muscle fiber atrophy (HP:0100295)1.68607959
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68331532
133Abnormal protein N-linked glycosylation (HP:0012347)1.68331532
134Abnormal protein glycosylation (HP:0012346)1.68331532
135Abnormal glycosylation (HP:0012345)1.68331532
136Abnormality of the renal collecting system (HP:0004742)1.68001991
137Pancreatic cysts (HP:0001737)1.66580935
138Facial cleft (HP:0002006)1.66526968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.70413498
2WEE14.30599590
3VRK24.01557099
4EIF2AK13.66388634
5NME23.44215258
6SRPK13.40706517
7CDC73.34797080
8STK162.65190797
9PLK42.55319178
10EIF2AK32.53603304
11ACVR1B2.48972488
12VRK12.40496092
13NEK22.34446671
14BRSK22.21230075
15DYRK32.14481545
16TTK2.06950123
17MKNK12.06052634
18PLK11.90621492
19AURKB1.76956692
20TLK11.65210618
21CDK71.63463423
22RPS6KB21.60937312
23MKNK21.59700051
24PLK31.52486260
25TESK21.40248267
26CHEK21.39154345
27PASK1.38369841
28RPS6KA41.37365684
29PBK1.36908062
30NEK11.34238611
31TSSK61.33608161
32AURKA1.32820127
33PDK21.32801167
34CDK81.30938288
35ATR1.27012442
36PIM21.25696014
37TAF11.25361812
38BRSK11.23937771
39MST41.22731724
40DYRK21.18888999
41BRAF1.12723339
42MAP3K121.11250013
43TGFBR11.09852539
44MAP3K81.06524401
45CCNB11.02260854
46EIF2AK21.02071274
47NME11.01740231
48CHEK10.98873122
49EPHA20.96958730
50CDK40.95421859
51LATS20.93807801
52STK100.90226019
53TRIM280.84780249
54PIM10.80649257
55STK38L0.78680768
56STK40.77517344
57RPS6KA50.76914961
58CSNK2A10.76722732
59ZAK0.75192652
60CSNK2A20.72314490
61ARAF0.72001713
62BCKDK0.71509041
63ABL20.71405096
64PAK40.71260408
65SMG10.70626590
66PAK10.69348186
67DAPK10.69286042
68LRRK20.69115982
69MELK0.68184432
70ATM0.67836933
71NLK0.67494194
72MAPKAPK30.65847223
73STK30.65121277
74CDK20.63069129
75ALK0.60216228
76TAOK20.59835371
77RAF10.59722575
78TNIK0.55306972
79KDR0.55147358
80CDK10.51494594
81LATS10.50969036
82MAP3K30.50556638
83PRKCI0.50272861
84TEC0.49438426
85CLK10.48066143
86ILK0.45212841
87MAP4K10.44811058
88MUSK0.44204082
89MAP3K110.42370998
90MAP3K100.42346993
91ITK0.41993557
92STK240.40821200
93DAPK30.39737999
94BMPR1B0.37238424
95ERBB40.36217125
96MAP3K60.35824428
97BRD40.35641915
98CSNK1G10.33565286
99AKT20.31346837
100EEF2K0.28937478
101LIMK10.28851881
102TXK0.28465125
103IKBKB0.28100081
104CDK190.26663558
105CDK11A0.26244647
106MAP3K90.25628100
107BTK0.25221478
108NUAK10.24280001
109CSNK1G30.24042148
110CDK90.23721061
111MOS0.23405757
112TESK10.23111774
113CSNK1E0.23101500
114CDK120.22236593
115CDK30.22058984
116DMPK0.21858339
117IRAK40.21367028
118IRAK30.21189491
119CDK140.20883550
120PNCK0.20136468
121CDK60.19474281
122MARK30.19286659
123SCYL20.19017248
124PRKG20.18650328
125CDK150.18520405

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.03520367
2DNA replication_Homo sapiens_hsa030304.23722152
3RNA polymerase_Homo sapiens_hsa030204.10658954
4Proteasome_Homo sapiens_hsa030503.81080823
5Mismatch repair_Homo sapiens_hsa034303.58081674
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55374682
7* Spliceosome_Homo sapiens_hsa030403.37963679
8Homologous recombination_Homo sapiens_hsa034402.92789793
9* RNA transport_Homo sapiens_hsa030132.88783946
10Nucleotide excision repair_Homo sapiens_hsa034202.77773750
11Pyrimidine metabolism_Homo sapiens_hsa002402.75040511
12Base excision repair_Homo sapiens_hsa034102.62734618
13Cell cycle_Homo sapiens_hsa041102.55840842
14Basal transcription factors_Homo sapiens_hsa030222.34581105
15Fanconi anemia pathway_Homo sapiens_hsa034602.16864341
16RNA degradation_Homo sapiens_hsa030182.13622293
17Non-homologous end-joining_Homo sapiens_hsa034501.87770146
18One carbon pool by folate_Homo sapiens_hsa006701.77792929
19Protein export_Homo sapiens_hsa030601.74539058
20p53 signaling pathway_Homo sapiens_hsa041151.62016711
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54945720
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46658281
23Purine metabolism_Homo sapiens_hsa002301.46337045
24* mRNA surveillance pathway_Homo sapiens_hsa030151.43549748
25Oxidative phosphorylation_Homo sapiens_hsa001901.34272320
26Huntingtons disease_Homo sapiens_hsa050161.31488486
27Parkinsons disease_Homo sapiens_hsa050121.30884403
28Epstein-Barr virus infection_Homo sapiens_hsa051691.19655790
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09898065
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00578902
31Systemic lupus erythematosus_Homo sapiens_hsa053220.99133642
32Pyruvate metabolism_Homo sapiens_hsa006200.95752894
33Cardiac muscle contraction_Homo sapiens_hsa042600.95480171
34Herpes simplex infection_Homo sapiens_hsa051680.89285061
35Folate biosynthesis_Homo sapiens_hsa007900.88185271
36Vitamin B6 metabolism_Homo sapiens_hsa007500.84321865
37Oocyte meiosis_Homo sapiens_hsa041140.84108333
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82670677
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76859224
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74487735
41Carbon metabolism_Homo sapiens_hsa012000.73048775
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70494980
43Alzheimers disease_Homo sapiens_hsa050100.68963539
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68759038
45Glutathione metabolism_Homo sapiens_hsa004800.67518164
46Antigen processing and presentation_Homo sapiens_hsa046120.67389007
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66729276
48Viral carcinogenesis_Homo sapiens_hsa052030.66430313
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.66307542
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65511809
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61843474
52Sulfur relay system_Homo sapiens_hsa041220.60781486
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58958315
54Pentose phosphate pathway_Homo sapiens_hsa000300.57821189
55Propanoate metabolism_Homo sapiens_hsa006400.56242889
56Fatty acid elongation_Homo sapiens_hsa000620.55942761
57HTLV-I infection_Homo sapiens_hsa051660.55900729
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.54418161
59Steroid biosynthesis_Homo sapiens_hsa001000.54155277
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53927582
61Thyroid cancer_Homo sapiens_hsa052160.48203207
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47793298
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46959181
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.45456406
65Legionellosis_Homo sapiens_hsa051340.45187485
66Primary immunodeficiency_Homo sapiens_hsa053400.43407196
67MicroRNAs in cancer_Homo sapiens_hsa052060.43255003
68TGF-beta signaling pathway_Homo sapiens_hsa043500.42904434
69Small cell lung cancer_Homo sapiens_hsa052220.40398510
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39778053
71Arachidonic acid metabolism_Homo sapiens_hsa005900.39731788
72Graft-versus-host disease_Homo sapiens_hsa053320.39718796
73Sulfur metabolism_Homo sapiens_hsa009200.38699134
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.35441571
75Basal cell carcinoma_Homo sapiens_hsa052170.33338983
76Apoptosis_Homo sapiens_hsa042100.32678165
77Allograft rejection_Homo sapiens_hsa053300.32613760
78Metabolic pathways_Homo sapiens_hsa011000.31402939
79Alcoholism_Homo sapiens_hsa050340.31284284
80Rheumatoid arthritis_Homo sapiens_hsa053230.31225445
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31002731
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.30697837
83Asthma_Homo sapiens_hsa053100.30465455
84Measles_Homo sapiens_hsa051620.28646350
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28536740
86Hematopoietic cell lineage_Homo sapiens_hsa046400.28185109
87Regulation of autophagy_Homo sapiens_hsa041400.28009391
88Hepatitis B_Homo sapiens_hsa051610.27326954
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27123813
90Selenocompound metabolism_Homo sapiens_hsa004500.26521377
91Linoleic acid metabolism_Homo sapiens_hsa005910.25487988
92Hippo signaling pathway_Homo sapiens_hsa043900.25337511
93Shigellosis_Homo sapiens_hsa051310.25236339
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24608642
95Viral myocarditis_Homo sapiens_hsa054160.22833275
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22683090
97Colorectal cancer_Homo sapiens_hsa052100.22526365
98N-Glycan biosynthesis_Homo sapiens_hsa005100.22370702
99Arginine and proline metabolism_Homo sapiens_hsa003300.21589182
100Biosynthesis of amino acids_Homo sapiens_hsa012300.19856288
101Hedgehog signaling pathway_Homo sapiens_hsa043400.18348166
102Pathways in cancer_Homo sapiens_hsa052000.16965471
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16427129
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16381263
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15248492
106Notch signaling pathway_Homo sapiens_hsa043300.15086354
107Autoimmune thyroid disease_Homo sapiens_hsa053200.14609206
108Influenza A_Homo sapiens_hsa051640.14138692
109Fructose and mannose metabolism_Homo sapiens_hsa000510.13964951
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12807796
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12479533
112Bladder cancer_Homo sapiens_hsa052190.12341724
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11532740
114Prostate cancer_Homo sapiens_hsa052150.10716895
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09926556
116Type I diabetes mellitus_Homo sapiens_hsa049400.09476731
117Ether lipid metabolism_Homo sapiens_hsa005650.08216948
118Galactose metabolism_Homo sapiens_hsa000520.06759041
119Vitamin digestion and absorption_Homo sapiens_hsa049770.06416707
120Sphingolipid metabolism_Homo sapiens_hsa006000.06415235
121Peroxisome_Homo sapiens_hsa041460.06306827
122Wnt signaling pathway_Homo sapiens_hsa043100.05291999
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05272463
124Collecting duct acid secretion_Homo sapiens_hsa049660.01590456

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