MAGED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). This gene may also be involved in several types of cancer, including breast cancer and melanoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.99194969
2endocardial cushion morphogenesis (GO:0003203)4.44997277
3COPI coating of Golgi vesicle (GO:0048205)4.27597107
4Golgi transport vesicle coating (GO:0048200)4.27597107
5glomerulus development (GO:0032835)4.27012489
6mesenchyme morphogenesis (GO:0072132)4.07305259
7metanephric mesenchyme development (GO:0072075)3.98627011
8lymph vessel development (GO:0001945)3.82082784
9cell proliferation involved in metanephros development (GO:0072203)3.80625227
10nucleobase catabolic process (GO:0046113)3.80004703
11kidney mesenchyme development (GO:0072074)3.79821282
12postsynaptic membrane organization (GO:0001941)3.74024773
13chondrocyte proliferation (GO:0035988)3.73453143
14endothelium development (GO:0003158)3.69355757
15presynaptic membrane assembly (GO:0097105)3.69186167
16basement membrane organization (GO:0071711)3.57027269
17nonmotile primary cilium assembly (GO:0035058)3.52632959
18intraciliary transport (GO:0042073)3.52278011
19extracellular fibril organization (GO:0043206)3.50885484
20respiratory tube development (GO:0030323)3.47188711
21calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.46885509
22cell proliferation involved in kidney development (GO:0072111)3.46382795
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.42790639
24axon extension involved in axon guidance (GO:0048846)3.42790639
25mesenchymal cell differentiation involved in kidney development (GO:0072161)3.41594180
26mesenchymal cell differentiation involved in renal system development (GO:2001012)3.41594180
27protein heterotrimerization (GO:0070208)3.39169006
28sequestering of actin monomers (GO:0042989)3.38573370
29presynaptic membrane organization (GO:0097090)3.36625915
30cell differentiation involved in metanephros development (GO:0072202)3.36392320
31diaphragm development (GO:0060539)3.35617294
32axonal fasciculation (GO:0007413)3.35004459
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31071424
34atrioventricular valve morphogenesis (GO:0003181)3.30893320
35positive regulation of vasculogenesis (GO:2001214)3.30657893
36retinal ganglion cell axon guidance (GO:0031290)3.29709287
37glomerular basement membrane development (GO:0032836)3.27808208
38skeletal muscle organ development (GO:0060538)3.24406128
39lung vasculature development (GO:0060426)3.17727797
40regulation of endothelial cell differentiation (GO:0045601)3.16957891
41neuron cell-cell adhesion (GO:0007158)3.16823356
42epithelial cilium movement (GO:0003351)3.16541245
43embryonic foregut morphogenesis (GO:0048617)3.14741108
44regulation of cardioblast differentiation (GO:0051890)3.11029618
45collagen fibril organization (GO:0030199)3.10490697
46regulation of cilium movement (GO:0003352)3.08666202
47negative regulation of catenin import into nucleus (GO:0035414)3.06091448
48protein retention in ER lumen (GO:0006621)3.05996752
49cardiac myofibril assembly (GO:0055003)3.05650381
50neuron recognition (GO:0008038)3.05302720
51organ formation (GO:0048645)3.02034774
52negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.00535176
53limb bud formation (GO:0060174)2.99838099
54regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.98353576
55positive regulation of male gonad development (GO:2000020)2.96118084
56bone trabecula formation (GO:0060346)2.93960443
57mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.93622347
58uterus development (GO:0060065)2.93257370
59outer ear morphogenesis (GO:0042473)2.92809151
60establishment of mitochondrion localization (GO:0051654)2.90912754
61lung morphogenesis (GO:0060425)2.88106764
62positive regulation of mitochondrial fission (GO:0090141)2.86826958
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86196900
64cilium movement (GO:0003341)2.85609031
65cell migration involved in heart development (GO:0060973)2.85600028
66atrial septum morphogenesis (GO:0060413)2.85211228
67fibril organization (GO:0097435)2.84884789
68auditory behavior (GO:0031223)2.84849817
69endocardial cushion development (GO:0003197)2.84474644
70regulation of vasculogenesis (GO:2001212)2.83904118
71cell differentiation involved in kidney development (GO:0061005)2.83388076
72gonadal mesoderm development (GO:0007506)2.83263928
73negative regulation of chondrocyte differentiation (GO:0032331)2.83241744
74cilium morphogenesis (GO:0060271)2.82433773
75G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.81157955
76mesenchymal cell proliferation (GO:0010463)2.81000546
77positive regulation of epithelial to mesenchymal transition (GO:0010718)2.80585010
78negative regulation of axon extension involved in axon guidance (GO:0048843)2.80380904
79cholesterol biosynthetic process (GO:0006695)2.79904250
80sequestering of extracellular ligand from receptor (GO:0035581)2.77994736
81heart valve morphogenesis (GO:0003179)2.76692711
82cellular response to BMP stimulus (GO:0071773)2.76438896
83response to BMP (GO:0071772)2.76438896
84epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.76387505
85cullin deneddylation (GO:0010388)2.74918529
86blood vessel maturation (GO:0001955)2.73103186
87cardiac epithelial to mesenchymal transition (GO:0060317)2.72650813
88regulation of male gonad development (GO:2000018)2.71988899
89trabecula formation (GO:0060343)2.70286915
90negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.70036249
91adrenal gland development (GO:0030325)2.69882692
92negative regulation of striated muscle cell apoptotic process (GO:0010664)2.69731961
93negative chemotaxis (GO:0050919)2.68674724
94proximal/distal pattern formation (GO:0009954)2.67335581
95axonemal dynein complex assembly (GO:0070286)2.66163689
96positive regulation of endothelial cell differentiation (GO:0045603)2.65579924
97outflow tract septum morphogenesis (GO:0003148)2.65549721
98regulation of glomerulus development (GO:0090192)2.64973273
99heart trabecula formation (GO:0060347)2.64602251
100polarized epithelial cell differentiation (GO:0030859)2.63000323
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62138475
102branching involved in ureteric bud morphogenesis (GO:0001658)2.60680003
103sterol biosynthetic process (GO:0016126)2.60659395
104synapse assembly (GO:0007416)2.60005786
105positive regulation of synapse assembly (GO:0051965)2.59325018
106hippo signaling (GO:0035329)2.59304533
107negative regulation of cartilage development (GO:0061037)2.59124355
108dendritic spine morphogenesis (GO:0060997)2.58686773
109embryonic skeletal joint morphogenesis (GO:0060272)2.57333798
110paraxial mesoderm development (GO:0048339)2.57189049
111body morphogenesis (GO:0010171)2.57031227
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.56754450
113exocrine pancreas development (GO:0031017)2.55414464
114regulation of axon guidance (GO:1902667)2.55021246
115mesenchymal to epithelial transition (GO:0060231)2.54975125
116mesenchyme development (GO:0060485)2.53935450
117protein localization to cilium (GO:0061512)2.53651013
118negative regulation of axon guidance (GO:1902668)2.53237014
119short-term memory (GO:0007614)2.52330552
120axon extension (GO:0048675)2.52314869
121protein localization to synapse (GO:0035418)2.52241702
122positive regulation of stem cell differentiation (GO:2000738)2.51399891
123chondrocyte development (GO:0002063)2.50484596
124regulation of secondary heart field cardioblast proliferation (GO:0003266)2.50434161
125regulation of cardioblast proliferation (GO:0003264)2.50434161
126midgut development (GO:0007494)2.50400815
127embryonic heart tube development (GO:0035050)2.50192029
128somite development (GO:0061053)2.49869392
129endothelial cell morphogenesis (GO:0001886)2.49414092
130negative regulation of embryonic development (GO:0045992)2.48771783
131vasculogenesis (GO:0001570)2.47738025
132positive regulation of cartilage development (GO:0061036)2.47150262
133DNA integration (GO:0015074)2.46834203
134atrial cardiac muscle cell action potential (GO:0086014)2.46374279
135regulation of heart morphogenesis (GO:2000826)2.46215063
136layer formation in cerebral cortex (GO:0021819)2.45793245
137lymphangiogenesis (GO:0001946)2.45691362
138cilium assembly (GO:0042384)2.39703770
139smoothened signaling pathway (GO:0007224)2.38202143
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37975665
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36534870
142cilium organization (GO:0044782)2.36455136
143protein deneddylation (GO:0000338)2.34818947
144regulation of microtubule-based movement (GO:0060632)2.34423022
145left/right pattern formation (GO:0060972)2.33798430
146ganglion development (GO:0061548)2.32502659
147regulation of development, heterochronic (GO:0040034)2.30984002
148vocalization behavior (GO:0071625)2.30202000
149cell migration in hindbrain (GO:0021535)2.29495312
150platelet dense granule organization (GO:0060155)2.27157932
151ephrin receptor signaling pathway (GO:0048013)2.26391064
152central nervous system projection neuron axonogenesis (GO:0021952)2.25316639
153homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.25105916
154response to auditory stimulus (GO:0010996)2.23488429
155dendritic spine organization (GO:0097061)2.22828598
156cellular response to leptin stimulus (GO:0044320)2.22185156
157transmission of nerve impulse (GO:0019226)2.21841112
158fatty acid elongation (GO:0030497)2.21657649
159limb development (GO:0060173)2.21435548
160appendage development (GO:0048736)2.21435548
161regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.20497968
162cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.19823796
163neurotransmitter-gated ion channel clustering (GO:0072578)2.19412429
164spinal cord development (GO:0021510)2.17533392
165mechanosensory behavior (GO:0007638)2.17044532
166hippocampus development (GO:0021766)2.15056190
167synapse organization (GO:0050808)2.14313884
168negative regulation of oligodendrocyte differentiation (GO:0048715)2.13617821
169axoneme assembly (GO:0035082)2.11058054
170protein polyglutamylation (GO:0018095)2.10924789
171type B pancreatic cell proliferation (GO:0044342)2.10527347
172establishment of planar polarity (GO:0001736)2.09919812
173establishment of tissue polarity (GO:0007164)2.09919812
174regulation of synapse structural plasticity (GO:0051823)2.08392057
175regulation of timing of cell differentiation (GO:0048505)2.06987209
176lens morphogenesis in camera-type eye (GO:0002089)2.06766609
177regulation of axon extension involved in axon guidance (GO:0048841)2.06629621
178regulation of synapse assembly (GO:0051963)2.06252952
179vascular smooth muscle contraction (GO:0014829)2.06116154
180aggressive behavior (GO:0002118)2.05167939
181lateral sprouting from an epithelium (GO:0060601)2.04933968
182cerebral cortex radially oriented cell migration (GO:0021799)2.04760858
183cytoskeleton-dependent intracellular transport (GO:0030705)2.01625296
184negative regulation of axon extension (GO:0030517)2.01479101
185axon regeneration (GO:0031103)2.00672264
186positive regulation of smoothened signaling pathway (GO:0045880)2.00185098
187regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.99663339
188peptidyl-cysteine modification (GO:0018198)1.98586306
189establishment of melanosome localization (GO:0032401)1.97326792
190lung-associated mesenchyme development (GO:0060484)1.96653206
191microtubule-based transport (GO:0010970)1.95680233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.17644844
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.59590650
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.54024982
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.44317180
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.36663446
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.20319418
7WT1_19549856_ChIP-ChIP_CCG9911_Human3.13592047
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.83837619
9PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.79776216
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70838145
11CLOCK_20551151_ChIP-Seq_293T_Human2.63647645
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63010782
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56834291
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.54012160
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52662975
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52662975
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48309849
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46980127
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33063753
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.32890339
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30012180
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20942652
23EP300_21415370_ChIP-Seq_HL-1_Mouse2.15623695
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.15392041
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13450489
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11736825
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.07599237
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04338826
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00734369
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.98411392
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.97737203
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96913342
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87000930
34TAF15_26573619_Chip-Seq_HEK293_Human1.85124744
35* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84000174
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81263503
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.79000481
38ISL1_27105846_Chip-Seq_CPCs_Mouse1.77368392
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75204968
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.74775368
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.74606294
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71831077
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69815790
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67913184
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67532515
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63367278
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59524109
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57352134
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56594908
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47378441
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45144491
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43134760
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.42718464
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41902994
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.40174073
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37386583
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37188037
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36747233
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36592209
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36106017
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35027508
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.32583093
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.31554542
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30801119
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30339259
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29447432
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27918383
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.27388625
69TP53_18474530_ChIP-ChIP_U2OS_Human1.26079331
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25580354
71IGF1R_20145208_ChIP-Seq_DFB_Human1.24663219
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23340911
73* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22900738
74BRD4_25478319_ChIP-Seq_HGPS_Human1.22688735
75EZH2_22144423_ChIP-Seq_EOC_Human1.22644087
76CJUN_26792858_Chip-Seq_BT549_Human1.22435413
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21928276
78SMAD4_21799915_ChIP-Seq_A2780_Human1.21879865
79REST_21632747_ChIP-Seq_MESCs_Mouse1.19477555
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19032082
81GBX2_23144817_ChIP-Seq_PC3_Human1.19010681
82* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17471326
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16844484
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15970189
85FUS_26573619_Chip-Seq_HEK293_Human1.15682952
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14395719
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13610176
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.11814571
89VDR_22108803_ChIP-Seq_LS180_Human1.11251430
90RNF2_27304074_Chip-Seq_NSC_Mouse1.11052829
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10834254
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.09845695
93ZNF274_21170338_ChIP-Seq_K562_Hela1.09026916
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08358646
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07873350
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.07738375
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06197004
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04644510
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04533498
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04387528
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04241798
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03267439
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02354230
104SOX9_26525672_Chip-Seq_HEART_Mouse1.02074508
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01931760
106* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01242682
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00232899
108* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00085579
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98852632
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98250453
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97772049
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97550904
113EWS_26573619_Chip-Seq_HEK293_Human0.96790603
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96075411
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95235289
116SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94721715
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93837967
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93796837
119AR_21572438_ChIP-Seq_LNCaP_Human0.92512837
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91927416
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.91788245
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91001652
123AR_25329375_ChIP-Seq_VCAP_Human0.90439622
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90429075
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90186781
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89858806
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88803576
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88290773
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87992110
130P300_19829295_ChIP-Seq_ESCs_Human0.86348515
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85995898
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85969315
133IRF1_19129219_ChIP-ChIP_H3396_Human0.85586200
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.85122949
135* EOMES_21245162_ChIP-Seq_HESCs_Human0.84580484
136* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84390053
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83975281
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.83244781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.52867779
2MP0004272_abnormal_basement_membrane3.75811572
3MP0008438_abnormal_cutaneous_collagen3.55071326
4MP0005503_abnormal_tendon_morphology3.52148585
5MP0003123_paternal_imprinting3.29529565
6MP0003121_genomic_imprinting3.23008084
7MP0010368_abnormal_lymphatic_system2.88747863
8MP0003385_abnormal_body_wall2.72952590
9MP0000537_abnormal_urethra_morphology2.59953343
10MP0003880_abnormal_central_pattern2.59106177
11MP0003279_aneurysm2.58400417
12MP0010030_abnormal_orbit_morphology2.55428453
13MP0001879_abnormal_lymphatic_vessel2.52223991
14MP0001529_abnormal_vocalization2.40983603
15MP0006054_spinal_hemorrhage2.38688232
16MP0003942_abnormal_urinary_system2.34993808
17MP0008789_abnormal_olfactory_epithelium2.31025415
18MP0005394_taste/olfaction_phenotype2.23273256
19MP0005499_abnormal_olfactory_system2.23273256
20MP0005623_abnormal_meninges_morphology2.18457921
21MP0002282_abnormal_trachea_morphology2.14932335
22MP0002653_abnormal_ependyma_morphology2.14293226
23MP0005275_abnormal_skin_tensile2.11050801
24MP0001984_abnormal_olfaction2.02293658
25MP0009250_abnormal_appendicular_skeleto1.97452095
26MP0000013_abnormal_adipose_tissue1.91619091
27MP0003115_abnormal_respiratory_system1.87710267
28MP0002102_abnormal_ear_morphology1.84065160
29MP0004859_abnormal_synaptic_plasticity1.75911841
30MP0003119_abnormal_digestive_system1.73447277
31MP0002938_white_spotting1.71124496
32MP0003787_abnormal_imprinting1.69738424
33MP0009053_abnormal_anal_canal1.68300134
34MP0000049_abnormal_middle_ear1.67400995
35MP0000534_abnormal_ureter_morphology1.67298703
36MP0004133_heterotaxia1.66955070
37MP0005508_abnormal_skeleton_morphology1.66528147
38MP0004270_analgesia1.63939425
39MP0003136_yellow_coat_color1.59895018
40MP0005171_absent_coat_pigmentation1.58341218
41MP0002822_catalepsy1.53800584
42MP0003705_abnormal_hypodermis_morpholog1.51833653
43MP0002249_abnormal_larynx_morphology1.49960611
44MP0002736_abnormal_nociception_after1.49359351
45MP0005167_abnormal_blood-brain_barrier1.49106534
46MP0000767_abnormal_smooth_muscle1.41742133
47MP0009379_abnormal_foot_pigmentation1.39346410
48MP0009384_cardiac_valve_regurgitation1.38259580
49MP0002638_abnormal_pupillary_reflex1.35890919
50MP0005248_abnormal_Harderian_gland1.35380775
51MP0000751_myopathy1.35195284
52MP0005423_abnormal_somatic_nervous1.34498050
53MP0003011_delayed_dark_adaptation1.31833241
54MP0001293_anophthalmia1.31630273
55MP0005367_renal/urinary_system_phenotyp1.28685454
56MP0000516_abnormal_urinary_system1.28685454
57MP0002108_abnormal_muscle_morphology1.26375671
58MP0002127_abnormal_cardiovascular_syste1.26004730
59MP0002932_abnormal_joint_morphology1.25711338
60MP0003283_abnormal_digestive_organ1.23974569
61MP0003935_abnormal_craniofacial_develop1.23665322
62MP0002557_abnormal_social/conspecific_i1.22838099
63MP0001958_emphysema1.21990317
64MP0002163_abnormal_gland_morphology1.21941372
65MP0005253_abnormal_eye_physiology1.19496591
66MP0003755_abnormal_palate_morphology1.19161397
67MP0000955_abnormal_spinal_cord1.18050146
68MP0006292_abnormal_olfactory_placode1.17300316
69MP0004134_abnormal_chest_morphology1.16930201
70MP0002734_abnormal_mechanical_nocicepti1.16459794
71MP0003315_abnormal_perineum_morphology1.16007165
72MP0001968_abnormal_touch/_nociception1.15306600
73MP0000163_abnormal_cartilage_morphology1.14995373
74MP0004084_abnormal_cardiac_muscle1.14938605
75MP0002909_abnormal_adrenal_gland1.14802264
76MP0006072_abnormal_retinal_apoptosis1.12711086
77MP0001486_abnormal_startle_reflex1.12121077
78MP0000026_abnormal_inner_ear1.11131996
79MP0002572_abnormal_emotion/affect_behav1.08928531
80MP0000678_abnormal_parathyroid_gland1.08896033
81MP0002184_abnormal_innervation1.07992699
82MP0000428_abnormal_craniofacial_morphol1.07266846
83MP0002234_abnormal_pharynx_morphology1.06644662
84MP0003937_abnormal_limbs/digits/tail_de1.06521293
85MP0003567_abnormal_fetal_cardiomyocyte1.05867299
86MP0000631_abnormal_neuroendocrine_gland1.05400071
87MP0002116_abnormal_craniofacial_bone1.05356751
88MP0001270_distended_abdomen1.02839186
89MP0006138_congestive_heart_failure1.02378477
90MP0003635_abnormal_synaptic_transmissio1.01480971
91MP0000462_abnormal_digestive_system1.01029350
92MP0005391_vision/eye_phenotype1.00147834
93MP0003938_abnormal_ear_development0.99886235
94MP0002752_abnormal_somatic_nervous0.98409107
95MP0002896_abnormal_bone_mineralization0.97986059
96MP0005257_abnormal_intraocular_pressure0.96952071
97MP0002109_abnormal_limb_morphology0.96606898
98MP0003861_abnormal_nervous_system0.94970244
99MP0002882_abnormal_neuron_morphology0.94670227
100MP0002115_abnormal_skeleton_extremities0.93399545
101MP0004197_abnormal_fetal_growth/weight/0.93311069
102MP0002063_abnormal_learning/memory/cond0.93047629
103MP0004145_abnormal_muscle_electrophysio0.92901698
104MP0001905_abnormal_dopamine_level0.92743632
105MP0005551_abnormal_eye_electrophysiolog0.92165973
106MP0005646_abnormal_pituitary_gland0.91937058
107MP0002152_abnormal_brain_morphology0.89724867
108MP0002092_abnormal_eye_morphology0.88660617
109MP0002114_abnormal_axial_skeleton0.87793322
110MP0002925_abnormal_cardiovascular_devel0.87055273
111MP0002128_abnormal_blood_circulation0.86899170
112MP0002233_abnormal_nose_morphology0.86034806
113MP0000003_abnormal_adipose_tissue0.85952601
114MP0006276_abnormal_autonomic_nervous0.85344218
115MP0002295_abnormal_pulmonary_circulatio0.85080212
116MP0005187_abnormal_penis_morphology0.83871485
117MP0004858_abnormal_nervous_system0.83168842
118MP0000647_abnormal_sebaceous_gland0.83062239
119MP0004811_abnormal_neuron_physiology0.82310388
120MP0009697_abnormal_copulation0.80935297
121MP0001286_abnormal_eye_development0.79987486
122MP0005195_abnormal_posterior_eye0.79944802
123MP0002735_abnormal_chemical_nociception0.79659243
124MP0000778_abnormal_nervous_system0.79352210
125MP0009745_abnormal_behavioral_response0.78852940
126MP0001299_abnormal_eye_distance/0.78488105
127MP0002972_abnormal_cardiac_muscle0.77364200
128MP0004085_abnormal_heartbeat0.77221694
129MP0000762_abnormal_tongue_morphology0.76319766
130MP0009780_abnormal_chondrocyte_physiolo0.75728233
131MP0002272_abnormal_nervous_system0.75662138
132MP0004036_abnormal_muscle_relaxation0.75115023
133MP0002090_abnormal_vision0.75087602
134MP0002751_abnormal_autonomic_nervous0.75079841
135MP0003566_abnormal_cell_adhesion0.74391864
136MP0009046_muscle_twitch0.74276099
137MP0002113_abnormal_skeleton_development0.74003784
138MP0002081_perinatal_lethality0.73937707
139MP0002697_abnormal_eye_size0.72700348
140MP0003943_abnormal_hepatobiliary_system0.72327967
141MP0001614_abnormal_blood_vessel0.72088057
142MP0001188_hyperpigmentation0.70605820
143MP0000266_abnormal_heart_morphology0.70452364
144MP0000639_abnormal_adrenal_gland0.69966118
145MP0001175_abnormal_lung_morphology0.69935238
146MP0001544_abnormal_cardiovascular_syste0.69109701
147MP0005385_cardiovascular_system_phenoty0.69109701
148MP0002177_abnormal_outer_ear0.68790122
149MP0000733_abnormal_muscle_development0.68749182
150MP0010386_abnormal_urinary_bladder0.67708535
151MP0005620_abnormal_muscle_contractility0.67109563
152MP0000566_synostosis0.66091781
153MP0005595_abnormal_vascular_smooth0.65844645
154MP0004233_abnormal_muscle_weight0.64838255
155MP0002111_abnormal_tail_morphology0.64736555

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.59571684
2Hepatoblastoma (HP:0002884)4.57810763
3Diastasis recti (HP:0001540)4.24632358
4Follicular hyperkeratosis (HP:0007502)3.79747820
5Abnormality of dentin (HP:0010299)3.59194308
6Asymmetry of the thorax (HP:0001555)3.52822445
7Gait imbalance (HP:0002141)3.49675216
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32294484
9Short 4th metacarpal (HP:0010044)3.32294484
10Congenital primary aphakia (HP:0007707)3.30669206
11Premature rupture of membranes (HP:0001788)3.24708311
12Medial flaring of the eyebrow (HP:0010747)3.22231639
13Abnormal pancreas size (HP:0012094)3.13139746
14Bladder diverticulum (HP:0000015)3.09780933
15Nephrogenic diabetes insipidus (HP:0009806)3.05995162
16Occipital encephalocele (HP:0002085)3.03211382
17Soft skin (HP:0000977)2.96937601
18Renal duplication (HP:0000075)2.92577158
19True hermaphroditism (HP:0010459)2.91242960
20Polyphagia (HP:0002591)2.89483098
21Metaphyseal dysplasia (HP:0100255)2.86837212
22Overgrowth (HP:0001548)2.85790613
23Hypoplastic left heart (HP:0004383)2.84587231
24Vaginal atresia (HP:0000148)2.81229056
25Genital tract atresia (HP:0001827)2.79744420
26Spinal rigidity (HP:0003306)2.70366440
27Embryonal renal neoplasm (HP:0011794)2.69386000
28Pancreatic fibrosis (HP:0100732)2.65602260
29Shallow orbits (HP:0000586)2.64956631
30Ankle contracture (HP:0006466)2.63343124
31Type 1 muscle fiber predominance (HP:0003803)2.59333634
32Lymphangioma (HP:0100764)2.59099668
33Neoplasm of the adrenal gland (HP:0100631)2.54340681
34Aortic dissection (HP:0002647)2.53408426
35Abnormality of the 4th metacarpal (HP:0010012)2.50531367
36Broad metatarsal (HP:0001783)2.44705222
37Mesomelia (HP:0003027)2.43144966
38Increased variability in muscle fiber diameter (HP:0003557)2.43106788
39Pancreatic cysts (HP:0001737)2.41122496
40Aortic aneurysm (HP:0004942)2.40436048
41Short tibia (HP:0005736)2.39939563
42Postaxial hand polydactyly (HP:0001162)2.39847823
43Epiphyseal dysplasia (HP:0002656)2.36491642
44Neoplasm of the adrenal cortex (HP:0100641)2.33861396
45Broad foot (HP:0001769)2.33546858
46Nephroblastoma (Wilms tumor) (HP:0002667)2.29504776
47Germ cell neoplasia (HP:0100728)2.29213520
48Vascular tortuosity (HP:0004948)2.27203410
49Postaxial foot polydactyly (HP:0001830)2.26232424
50Molar tooth sign on MRI (HP:0002419)2.25733027
51Abnormality of midbrain morphology (HP:0002418)2.25733027
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25135184
53Abnormality of skeletal muscle fiber size (HP:0012084)2.22776914
54Enlarged kidneys (HP:0000105)2.19674810
55Abnormal respiratory epithelium morphology (HP:0012253)2.19672527
56Abnormal respiratory motile cilium morphology (HP:0005938)2.19672527
57Retinal dysplasia (HP:0007973)2.18397757
58Morphological abnormality of the middle ear (HP:0008609)2.18068201
59Wormian bones (HP:0002645)2.15868222
60Broad toe (HP:0001837)2.15773479
61Hypoplastic heart (HP:0001961)2.15216513
62Abnormality of the aortic arch (HP:0012303)2.15202130
63Renal hypoplasia (HP:0000089)2.12920214
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.12011159
65Neonatal short-limb short stature (HP:0008921)2.11520993
66Abnormal ciliary motility (HP:0012262)2.10237091
67Midline defect of the nose (HP:0004122)2.09775189
68Abnormality of the labia minora (HP:0012880)2.09640298
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.09251352
70Arterial tortuosity (HP:0005116)2.08523387
71Vitreoretinal degeneration (HP:0000655)2.07857167
72Nephronophthisis (HP:0000090)2.07636172
73Biconcave vertebral bodies (HP:0004586)2.07621470
74Cortical dysplasia (HP:0002539)2.06504421
75Hyperglycinemia (HP:0002154)2.06407056
76Rhinitis (HP:0012384)2.05847682
77Subacute progressive viral hepatitis (HP:0006572)2.05589043
78Poor coordination (HP:0002370)2.04938370
79Broad long bones (HP:0005622)2.04667096
80Decreased testicular size (HP:0008734)2.04158601
81Abnormal respiratory motile cilium physiology (HP:0012261)2.02323015
82Limb dystonia (HP:0002451)2.02202380
83Fragile skin (HP:0001030)2.02058943
84Hemiparesis (HP:0001269)2.01914944
85Myelomeningocele (HP:0002475)2.00959475
86Anophthalmia (HP:0000528)2.00441937
87Ulnar claw (HP:0001178)2.00344638
88Rimmed vacuoles (HP:0003805)1.99940756
89Sclerocornea (HP:0000647)1.98929048
90Anencephaly (HP:0002323)1.98846257
91Short 5th finger (HP:0009237)1.98078763
92Preaxial hand polydactyly (HP:0001177)1.98033214
93Hypoplastic pelvis (HP:0008839)1.97953999
94Cerebral aneurysm (HP:0004944)1.97852122
95Wide anterior fontanel (HP:0000260)1.97266061
96Hypoventilation (HP:0002791)1.97132620
97Specific learning disability (HP:0001328)1.95506740
98Keratoconus (HP:0000563)1.95297948
99Increased corneal curvature (HP:0100692)1.95297948
100Missing ribs (HP:0000921)1.93974649
101Aplasia/Hypoplasia of the lens (HP:0008063)1.93367148
102Myokymia (HP:0002411)1.93247611
103Broad ribs (HP:0000885)1.93050846
104Blue sclerae (HP:0000592)1.91148201
105Mildly elevated creatine phosphokinase (HP:0008180)1.89397428
106Tubulointerstitial nephritis (HP:0001970)1.88732704
107Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88666070
108Cutaneous finger syndactyly (HP:0010554)1.87296011
109Mesangial abnormality (HP:0001966)1.86412038
110Joint laxity (HP:0001388)1.86062430
111Atrophic scars (HP:0001075)1.86001454
112Hyperextensible skin (HP:0000974)1.85747507
113Broad phalanx (HP:0006009)1.85589000
114Cutaneous syndactyly (HP:0012725)1.85422491
115Cystic liver disease (HP:0006706)1.85114083
116Neonatal hypoglycemia (HP:0001998)1.83669920
117Cervical subluxation (HP:0003308)1.82926481
118Sprengel anomaly (HP:0000912)1.82031565
119Shoulder girdle muscle weakness (HP:0003547)1.82004383
120Narrow forehead (HP:0000341)1.81983903
121Pachygyria (HP:0001302)1.81371582
122Delayed gross motor development (HP:0002194)1.81040722
123Poor suck (HP:0002033)1.80872333
124Broad finger (HP:0001500)1.80402415
125Preaxial foot polydactyly (HP:0001841)1.79958156
126Lissencephaly (HP:0001339)1.79172725
127Osteopenia (HP:0000938)1.78760907
128Adrenal hypoplasia (HP:0000835)1.78189477
129Failure to thrive in infancy (HP:0001531)1.78061738
130Abnormality of the musculature of the pelvis (HP:0001469)1.77833274
131Abnormality of the hip-girdle musculature (HP:0001445)1.77833274
132Shawl scrotum (HP:0000049)1.77295346
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76991893
134Hypoplasia of the brainstem (HP:0002365)1.76991893
135Mild short stature (HP:0003502)1.76431000
136Buphthalmos (HP:0000557)1.74827590
137Long toe (HP:0010511)1.74825554
138Abnormality of the calcaneus (HP:0008364)1.74558587
139Increased serum pyruvate (HP:0003542)1.74397550
140Trigonocephaly (HP:0000243)1.73528182
141Broad thumb (HP:0011304)1.73051831
142Bifid tongue (HP:0010297)1.72835398
143Nonimmune hydrops fetalis (HP:0001790)1.72815670
144Vertebral compression fractures (HP:0002953)1.72569133
145Micropenis (HP:0000054)1.72233894
146Wrist flexion contracture (HP:0001239)1.71818440
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.71077365
148Broad phalanges of the hand (HP:0009768)1.70648492
149Back pain (HP:0003418)1.69839054
150Narrow nasal bridge (HP:0000446)1.69155828
151Dental crowding (HP:0000678)1.68782021
152Neonatal respiratory distress (HP:0002643)1.68732451
153Testicular neoplasm (HP:0010788)1.68087649
154Protruding ear (HP:0000411)1.67524695
155Transposition of the great arteries (HP:0001669)1.67410416
156Abnormal connection of the cardiac segments (HP:0011545)1.67410416
157Abnormal ventriculo-arterial connection (HP:0011563)1.67410416
158Pulmonary artery stenosis (HP:0004415)1.66977867
159Renal dysplasia (HP:0000110)1.66459372
160Ectopia lentis (HP:0001083)1.65666789
161Dilatation of the ascending aorta (HP:0005111)1.65385416
162Drooling (HP:0002307)1.65075530
163Tarsal synostosis (HP:0008368)1.64475111
164Acute necrotizing encephalopathy (HP:0006965)1.64351389
165Mitral valve prolapse (HP:0001634)1.62825466
166Neoplasm of the heart (HP:0100544)1.62530301
167Abnormality of glycolysis (HP:0004366)1.62522503
168Split foot (HP:0001839)1.62018961
169Single umbilical artery (HP:0001195)1.61536320
170Abnormality of the fetal cardiovascular system (HP:0010948)1.61536320
171Abnormal umbilical cord blood vessels (HP:0011403)1.61536320
172Absent eyebrow (HP:0002223)1.60630095
173Colon cancer (HP:0003003)1.59356236
174Amyotrophic lateral sclerosis (HP:0007354)1.58743369
175Short foot (HP:0001773)1.58423834
176Focal motor seizures (HP:0011153)1.57809093
177Abnormality of the renal medulla (HP:0100957)1.57323054
178Left ventricular hypertrophy (HP:0001712)1.56190500
179Abnormality of the metopic suture (HP:0005556)1.55522366
180Thyroid-stimulating hormone excess (HP:0002925)1.53954340
181Decreased muscle mass (HP:0003199)1.53728568
182Abnormality of the lower motor neuron (HP:0002366)1.52573392
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52340238
184Absent epiphyses (HP:0010577)1.52340238
185Hand muscle atrophy (HP:0009130)1.51857597
186High anterior hairline (HP:0009890)1.50143979
187Infantile muscular hypotonia (HP:0008947)1.49902821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.46106127
2LATS23.31317128
3EPHB23.13499531
4MAP4K22.99179102
5MYLK2.87451405
6DDR22.86018931
7PTK2B2.80159055
8FER2.70279447
9PDGFRA2.62990425
10ERBB32.47275654
11EPHA42.34665884
12BCKDK2.27322236
13LIMK12.22616239
14TGFBR12.16875685
15PLK22.13693689
16CSNK1G22.10406131
17TRIM282.06075702
18CSNK1G11.99563705
19PKN21.96043535
20MAPK131.95436183
21LATS11.95407390
22KDR1.93583576
23PRKD31.86603071
24MARK11.78758912
25PINK11.69025452
26TRIB31.67643960
27PAK31.65978918
28PTK61.63521696
29AKT31.61821712
30UHMK11.54191418
31WNK31.50770873
32TESK11.44209577
33DYRK21.42219445
34EPHA31.42119926
35PASK1.32187322
36ILK1.31613841
37BCR1.30682906
38STK161.28267544
39PDK21.27520158
40ROCK11.25744354
41OBSCN1.24976114
42PTK21.23553063
43TYRO31.21452111
44MINK11.20283940
45PAK21.16332252
46STK38L1.13806610
47KSR11.12262199
48VRK21.09669930
49DYRK1B1.08663894
50PAK41.07142154
51FGFR21.07042983
52CDK81.05872363
53PAK61.04563354
54DYRK31.04385038
55NEK91.00569626
56TSSK60.96450529
57DMPK0.96297716
58PHKG20.95378271
59PHKG10.95378271
60STK240.92819913
61PDGFRB0.90271832
62CDK190.89446237
63ADRBK10.87462899
64EPHB10.86098249
65TNIK0.84440505
66NUAK10.81246826
67LMTK20.81033772
68FGFR10.80387644
69RIPK10.78789457
70PRKCG0.78220776
71CASK0.77639986
72PRKCE0.77451038
73CDK140.77117541
74ERN10.76387888
75MAP2K40.76225416
76PLK30.73429601
77MKNK10.72684235
78MET0.71379084
79TTN0.69539331
80CDC42BPA0.69423710
81TGFBR20.67609797
82ROCK20.66859388
83PIM20.66375135
84CDK180.64957082
85CDK50.64564030
86NTRK20.63371502
87PIK3CA0.63263904
88PNCK0.61825834
89VRK10.60203433
90CAMK2A0.60149036
91ADRBK20.57476624
92BMPR1B0.57379323
93CSNK1A10.56454892
94CDK150.56049872
95RPS6KA20.55915262
96SIK30.55662587
97MAPK150.53287514
98MAPKAPK30.52474445
99RET0.51144928
100NTRK10.50969074
101TESK20.50516792
102RPS6KA40.48287574
103WNK40.47919657
104MAP2K10.47509790
105LRRK20.47229529
106MAP3K100.47104253
107SRPK10.46840674
108INSRR0.46664711
109GRK10.46653967
110CDK11A0.46638840
111NTRK30.46354483
112CCNB10.44429823
113IGF1R0.43269394
114CAMK2G0.42952083
115STK30.42310735
116AKT20.41441226
117CAMK2D0.40372878
118FLT30.39985319
119SRC0.39597952
120MAP3K120.38824529
121ERBB20.38495745
122PRKACA0.38408928
123CAMK2B0.37899368
124MAP2K70.37806504
125BRSK10.36128007
126MAPK90.36043430
127MKNK20.35510530
128CSNK1A1L0.35500897
129ERBB40.35034831
130MAPKAPK50.34822521
131MAP3K40.34796775
132PKN10.34680368
133GRK50.34145477
134MAPK120.31929905
135DYRK1A0.31020075
136CAMK40.30858372
137PAK10.30366581
138PRKG20.29674174
139RPS6KC10.28717242
140RPS6KL10.28717242
141PRKCZ0.28445592
142MAP3K110.28114779
143PRKCH0.27944712
144CSNK1G30.27806490

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.89715788
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89120367
3ECM-receptor interaction_Homo sapiens_hsa045122.41203448
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40681031
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36087152
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33425680
7Fatty acid elongation_Homo sapiens_hsa000622.32830966
8Basal cell carcinoma_Homo sapiens_hsa052172.31405147
9Hedgehog signaling pathway_Homo sapiens_hsa043402.22907623
10Focal adhesion_Homo sapiens_hsa045102.22502522
11Protein export_Homo sapiens_hsa030602.17554154
12Dilated cardiomyopathy_Homo sapiens_hsa054142.16868358
13Hippo signaling pathway_Homo sapiens_hsa043902.07453424
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00428732
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95672073
16Adherens junction_Homo sapiens_hsa045201.90885966
17Axon guidance_Homo sapiens_hsa043601.83307187
18TGF-beta signaling pathway_Homo sapiens_hsa043501.75648487
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74453716
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74297770
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72206416
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70372993
23Butanoate metabolism_Homo sapiens_hsa006501.68674939
24Vibrio cholerae infection_Homo sapiens_hsa051101.64500053
25Protein digestion and absorption_Homo sapiens_hsa049741.64032430
26Propanoate metabolism_Homo sapiens_hsa006401.56140003
27Melanogenesis_Homo sapiens_hsa049161.55867170
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53336026
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52931644
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47877726
31Tight junction_Homo sapiens_hsa045301.46477214
32Proteoglycans in cancer_Homo sapiens_hsa052051.44259105
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42745829
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40661062
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40453719
36Cardiac muscle contraction_Homo sapiens_hsa042601.40338373
37Parkinsons disease_Homo sapiens_hsa050121.40320440
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39989535
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36157344
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35213887
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33862945
42Wnt signaling pathway_Homo sapiens_hsa043101.33155612
43Nicotine addiction_Homo sapiens_hsa050331.30585266
44Gap junction_Homo sapiens_hsa045401.30359912
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26565576
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23363446
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23279481
48Fatty acid metabolism_Homo sapiens_hsa012121.21752513
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20781875
50N-Glycan biosynthesis_Homo sapiens_hsa005101.18370250
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17697375
52Cocaine addiction_Homo sapiens_hsa050301.15367636
53Biosynthesis of amino acids_Homo sapiens_hsa012301.10207673
54Peroxisome_Homo sapiens_hsa041461.10086379
55Oxidative phosphorylation_Homo sapiens_hsa001901.09764203
56Cell cycle_Homo sapiens_hsa041101.09184219
57Prostate cancer_Homo sapiens_hsa052151.09088131
58Endometrial cancer_Homo sapiens_hsa052131.09056775
59Phototransduction_Homo sapiens_hsa047441.08865776
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08172015
61Pathways in cancer_Homo sapiens_hsa052001.07783578
62Rap1 signaling pathway_Homo sapiens_hsa040151.07117943
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.07107254
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06553588
65MicroRNAs in cancer_Homo sapiens_hsa052061.05474510
66Oocyte meiosis_Homo sapiens_hsa041141.04994262
67Synaptic vesicle cycle_Homo sapiens_hsa047211.04789520
68Huntingtons disease_Homo sapiens_hsa050161.02884103
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01963364
70Insulin secretion_Homo sapiens_hsa049110.98189269
71Circadian entrainment_Homo sapiens_hsa047130.97975108
72Colorectal cancer_Homo sapiens_hsa052100.96756902
73Pyruvate metabolism_Homo sapiens_hsa006200.96225031
74Glutathione metabolism_Homo sapiens_hsa004800.95578995
75Dopaminergic synapse_Homo sapiens_hsa047280.94181314
76Melanoma_Homo sapiens_hsa052180.93677359
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.93659406
78Cholinergic synapse_Homo sapiens_hsa047250.92670019
79Carbon metabolism_Homo sapiens_hsa012000.91589708
80beta-Alanine metabolism_Homo sapiens_hsa004100.89439610
81Thyroid cancer_Homo sapiens_hsa052160.89134124
82Alzheimers disease_Homo sapiens_hsa050100.89007097
83Estrogen signaling pathway_Homo sapiens_hsa049150.88046278
84Notch signaling pathway_Homo sapiens_hsa043300.88004950
85Renal cell carcinoma_Homo sapiens_hsa052110.87378755
86Bladder cancer_Homo sapiens_hsa052190.87030449
87Glioma_Homo sapiens_hsa052140.86786062
88Oxytocin signaling pathway_Homo sapiens_hsa049210.86301245
89mRNA surveillance pathway_Homo sapiens_hsa030150.85555952
90Collecting duct acid secretion_Homo sapiens_hsa049660.84394700
91Sulfur relay system_Homo sapiens_hsa041220.84267112
92Viral myocarditis_Homo sapiens_hsa054160.83950048
93GABAergic synapse_Homo sapiens_hsa047270.83376862
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82281121
95Ovarian steroidogenesis_Homo sapiens_hsa049130.80643603
96Amphetamine addiction_Homo sapiens_hsa050310.80449679
97Arginine and proline metabolism_Homo sapiens_hsa003300.80349985
98Small cell lung cancer_Homo sapiens_hsa052220.79701810
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78657741
100Amoebiasis_Homo sapiens_hsa051460.77238420
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73705702
102Renin secretion_Homo sapiens_hsa049240.73052036
103Thyroid hormone synthesis_Homo sapiens_hsa049180.72043606
104HTLV-I infection_Homo sapiens_hsa051660.71647084
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.70338357
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70257882
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70144636
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69821044
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69275300
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69116427
111Taste transduction_Homo sapiens_hsa047420.68911046
112Platelet activation_Homo sapiens_hsa046110.67167766
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66980372
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.65902622
115Folate biosynthesis_Homo sapiens_hsa007900.65708981
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.65076581
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.63989312
118Glutamatergic synapse_Homo sapiens_hsa047240.63915191
119Metabolic pathways_Homo sapiens_hsa011000.63664669
120Serotonergic synapse_Homo sapiens_hsa047260.61901501
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61673820
122Ras signaling pathway_Homo sapiens_hsa040140.61234171
123Long-term depression_Homo sapiens_hsa047300.61011718
124Glucagon signaling pathway_Homo sapiens_hsa049220.60851725
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.59976858
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59923053
127Phagosome_Homo sapiens_hsa041450.59323316
128Long-term potentiation_Homo sapiens_hsa047200.59069830
129GnRH signaling pathway_Homo sapiens_hsa049120.58108229
130RNA polymerase_Homo sapiens_hsa030200.57962722
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57523754
132Selenocompound metabolism_Homo sapiens_hsa004500.57216248
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.56726932
134Morphine addiction_Homo sapiens_hsa050320.55814014
135Alcoholism_Homo sapiens_hsa050340.55545957
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55106572
137Tyrosine metabolism_Homo sapiens_hsa003500.54334416
138Chronic myeloid leukemia_Homo sapiens_hsa052200.54031804
139Fatty acid degradation_Homo sapiens_hsa000710.53499658
140RNA degradation_Homo sapiens_hsa030180.52953408
141Proteasome_Homo sapiens_hsa030500.52870006
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52496426
143cAMP signaling pathway_Homo sapiens_hsa040240.52344317
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51085015
145Tryptophan metabolism_Homo sapiens_hsa003800.50436332
146Base excision repair_Homo sapiens_hsa034100.50183010
147Prion diseases_Homo sapiens_hsa050200.49421308
148Pancreatic cancer_Homo sapiens_hsa052120.49391038
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.47073823
150Regulation of autophagy_Homo sapiens_hsa041400.44765878
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44016417
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39816006
153Nitrogen metabolism_Homo sapiens_hsa009100.39064791
154Salivary secretion_Homo sapiens_hsa049700.38461780
155Histidine metabolism_Homo sapiens_hsa003400.37732655
156Chemical carcinogenesis_Homo sapiens_hsa052040.36987722
157Circadian rhythm_Homo sapiens_hsa047100.34908754

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