MAGEB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.85009827
2binding of sperm to zona pellucida (GO:0007339)9.73970336
3reproduction (GO:0000003)9.71534846
4sperm motility (GO:0030317)9.69426336
5positive regulation of male gonad development (GO:2000020)9.65180399
6synaptonemal complex assembly (GO:0007130)8.99212808
7regulation of female gonad development (GO:2000194)8.47380613
8axonemal dynein complex assembly (GO:0070286)8.40649574
9synaptonemal complex organization (GO:0070193)8.38787392
10plasma membrane fusion (GO:0045026)8.20065205
11acrosome reaction (GO:0007340)7.94986667
12negative regulation of metanephros development (GO:0072217)7.87082627
13regulation of male gonad development (GO:2000018)7.75317090
14metanephric mesenchyme development (GO:0072075)7.48798773
15piRNA metabolic process (GO:0034587)7.42328023
16regulation of cilium movement (GO:0003352)7.34253670
17spermatid development (GO:0007286)7.01788541
18microtubule severing (GO:0051013)6.97571129
19cilium movement (GO:0003341)6.96285282
20single fertilization (GO:0007338)6.84852951
21cellular response to gonadotropin stimulus (GO:0071371)6.76327555
22parturition (GO:0007567)6.63818709
23epithelial cilium movement (GO:0003351)6.63518460
24endocardial cushion development (GO:0003197)6.60755998
25negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.54221001
26kidney mesenchyme development (GO:0072074)6.46465328
27cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.46240594
28diaphragm development (GO:0060539)6.39883173
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.38729863
30glomerulus development (GO:0032835)6.37629910
31chromosome organization involved in meiosis (GO:0070192)6.25087041
32regulation of cardioblast differentiation (GO:0051890)6.19241937
33protein polyglutamylation (GO:0018095)6.12392830
34spermatid nucleus differentiation (GO:0007289)6.02741687
35atrioventricular valve morphogenesis (GO:0003181)6.01371297
36skeletal muscle organ development (GO:0060538)5.93247783
37embryonic foregut morphogenesis (GO:0048617)5.92698696
38peptidyl-lysine dimethylation (GO:0018027)5.89364261
39cardiac right ventricle morphogenesis (GO:0003215)5.87061741
40regulation of gonadotropin secretion (GO:0032276)5.75037791
41regulation of cell proliferation involved in kidney development (GO:1901722)5.59640750
42glomerular basement membrane development (GO:0032836)5.44159363
43endoderm formation (GO:0001706)5.41184226
44mesonephros development (GO:0001823)5.37617292
45fertilization (GO:0009566)5.33680063
46cell recognition (GO:0008037)5.32119646
47epithelial cell fate commitment (GO:0072148)5.28534487
48meiotic nuclear division (GO:0007126)5.27875041
49muscle cell fate commitment (GO:0042693)5.19095812
50ventricular system development (GO:0021591)5.17795439
51regulation of mesenchymal cell apoptotic process (GO:2001053)5.12561781
52epithelial cell differentiation involved in kidney development (GO:0035850)5.07834498
53response to gonadotropin (GO:0034698)5.04376180
54histone H3-K9 methylation (GO:0051567)5.00294925
55positive regulation of heart growth (GO:0060421)4.93405304
56regulation of glomerulus development (GO:0090192)4.90298829
57positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.87983817
58histone H3-K9 modification (GO:0061647)4.80185394
59protein kinase C signaling (GO:0070528)4.77105256
60motile cilium assembly (GO:0044458)4.76340380
61monoubiquitinated protein deubiquitination (GO:0035520)4.69056171
62male meiosis I (GO:0007141)4.66876194
63mesenchymal to epithelial transition (GO:0060231)4.65542203
64cellular process involved in reproduction in multicellular organism (GO:0022412)4.65442055
65prenylation (GO:0097354)4.61766094
66protein prenylation (GO:0018342)4.61766094
67regulation of female receptivity (GO:0045924)4.61283116
68DNA synthesis involved in DNA repair (GO:0000731)4.57084019
69DNA methylation involved in gamete generation (GO:0043046)4.52902703
70sex determination (GO:0007530)4.49541124
71reproductive system development (GO:0061458)4.44802057
72response to follicle-stimulating hormone (GO:0032354)4.43301071
73negative regulation of kidney development (GO:0090185)4.33961555
74pantothenate metabolic process (GO:0015939)4.33829830
75negative regulation of macrophage differentiation (GO:0045650)4.33495532
76signal transduction involved in regulation of gene expression (GO:0023019)4.30571747
77spermatogenesis (GO:0007283)4.28965972
78male gamete generation (GO:0048232)4.28036672
79SMAD protein signal transduction (GO:0060395)4.19389485
80cardiac muscle adaptation (GO:0014887)4.16913412
81cardiac muscle hypertrophy in response to stress (GO:0014898)4.16913412
82muscle hypertrophy in response to stress (GO:0003299)4.16913412
83regulation of cardiac muscle cell contraction (GO:0086004)4.13687409
84regulation of microtubule-based movement (GO:0060632)4.13289903
85peptidyl-lysine methylation (GO:0018022)4.12423981
86sex differentiation (GO:0007548)4.09982689
87male genitalia development (GO:0030539)4.09685387
88synapsis (GO:0007129)4.03485521
89positive regulation of mesonephros development (GO:0061213)3.99415143
90regulation of inositol phosphate biosynthetic process (GO:0010919)3.96976591
91gamete generation (GO:0007276)3.92550058
92female mating behavior (GO:0060180)3.92517423
93organic cation transport (GO:0015695)3.84683922
94negative regulation of reproductive process (GO:2000242)3.83894483
95germ cell development (GO:0007281)3.80679211
96cardiac muscle hypertrophy (GO:0003300)3.77085081
97meiosis I (GO:0007127)3.77037918
98metanephric epithelium development (GO:0072207)3.74000194
99atrial septum morphogenesis (GO:0060413)3.73832883
100regulation of DNA endoreduplication (GO:0032875)3.72514856
101regulation of RIG-I signaling pathway (GO:0039535)3.65808601
102positive regulation of metanephros development (GO:0072216)3.65599476
103meiotic chromosome segregation (GO:0045132)3.65060031
104calcium ion-dependent exocytosis (GO:0017156)3.63621681
105negative regulation of circadian rhythm (GO:0042754)3.60285971
106positive regulation of organ growth (GO:0046622)3.56643372
107gastrulation with mouth forming second (GO:0001702)3.55684048
108striated muscle hypertrophy (GO:0014897)3.53724308
109DNA replication-dependent nucleosome assembly (GO:0006335)3.48834451
110DNA replication-dependent nucleosome organization (GO:0034723)3.48834451
111regulation of somitogenesis (GO:0014807)3.45062447
112protein K6-linked ubiquitination (GO:0085020)3.44651840
113heparin metabolic process (GO:0030202)3.40244647
114heparin biosynthetic process (GO:0030210)3.40244647
115regulation of mesonephros development (GO:0061217)3.39074918
116regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.38023512
117negative regulation of organelle assembly (GO:1902116)3.32986997
118reciprocal DNA recombination (GO:0035825)3.30503115
119reciprocal meiotic recombination (GO:0007131)3.30503115
120calcium ion import (GO:0070509)3.30187826
121meiotic cell cycle process (GO:1903046)3.28891394
122regulation of heart growth (GO:0060420)3.24807746
123regulation of transforming growth factor beta2 production (GO:0032909)3.22708788
124positive regulation of macrophage activation (GO:0043032)3.20252649
125regulation of chromatin binding (GO:0035561)3.20030855
126negative regulation of inclusion body assembly (GO:0090084)3.17840777
127positive regulation of reproductive process (GO:2000243)3.15128060
128cell-cell junction maintenance (GO:0045217)3.12946242
129regulation of actin filament-based movement (GO:1903115)3.10773969
130embryonic digestive tract morphogenesis (GO:0048557)3.09925374
131carnitine transmembrane transport (GO:1902603)3.09459455
132ventricular septum development (GO:0003281)3.08910096
133rRNA catabolic process (GO:0016075)3.04318480
134genitalia morphogenesis (GO:0035112)3.04251468
135male sex determination (GO:0030238)3.03407413
136regulation of spindle checkpoint (GO:0090231)3.03270557
137multicellular organismal reproductive process (GO:0048609)3.02792795
138protein-chromophore linkage (GO:0018298)3.01474670
139regulation of centriole replication (GO:0046599)3.00510931
140muscle hypertrophy (GO:0014896)2.98416734
141membrane depolarization during action potential (GO:0086010)2.97745060
142peptidyl-glutamic acid modification (GO:0018200)2.96944257
143amino-acid betaine transport (GO:0015838)2.95694410
144carnitine transport (GO:0015879)2.95694410
145proteasome assembly (GO:0043248)2.95310163
146nephron tubule formation (GO:0072079)2.93727491
147intraciliary transport (GO:0042073)2.92931281
148regulation of mesoderm development (GO:2000380)2.89976304
149histone exchange (GO:0043486)2.89684118
150gene silencing by RNA (GO:0031047)2.89109499
151positive regulation of cardiac muscle cell proliferation (GO:0060045)2.88550960
152resolution of meiotic recombination intermediates (GO:0000712)2.87808940
153mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.84991091
154positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.84991091
155protein localization to cilium (GO:0061512)2.84243304
156intra-S DNA damage checkpoint (GO:0031573)2.82074368
157DNA damage response, signal transduction resulting in transcription (GO:0042772)2.80621159
158microtubule depolymerization (GO:0007019)2.74737234
159negative regulation of transcription by competitive promoter binding (GO:0010944)2.70700961
160regulation of inclusion body assembly (GO:0090083)2.69499688
161regulation of RNA export from nucleus (GO:0046831)2.69414950
162peptidyl-lysine trimethylation (GO:0018023)2.67201473
163microtubule-based movement (GO:0007018)2.65079395
164seminiferous tubule development (GO:0072520)2.60034078
165DNA deamination (GO:0045006)2.54686455
166meiotic cell cycle (GO:0051321)2.53937056
167negative regulation of necroptotic process (GO:0060546)2.53666991
168nuclear pore complex assembly (GO:0051292)2.50920626
169cellular component assembly involved in morphogenesis (GO:0010927)2.50916599
170negative regulation of B cell mediated immunity (GO:0002713)2.48262950
171negative regulation of immunoglobulin mediated immune response (GO:0002890)2.48262950
172protein K11-linked deubiquitination (GO:0035871)2.46945375
173deoxyribose phosphate biosynthetic process (GO:0046385)2.46626480
1742-deoxyribonucleotide biosynthetic process (GO:0009265)2.46626480
175cilium organization (GO:0044782)2.45778336
176acrosome assembly (GO:0001675)15.5855865
177negative regulation of retinoic acid receptor signaling pathway (GO:0048387)14.0324311
178cilium or flagellum-dependent cell motility (GO:0001539)12.9006236
179cell wall macromolecule metabolic process (GO:0044036)12.7657070
180cell wall macromolecule catabolic process (GO:0016998)12.7657070
181multicellular organism reproduction (GO:0032504)12.4190774
182sperm-egg recognition (GO:0035036)12.1081594
183regulation of retinoic acid receptor signaling pathway (GO:0048385)11.6509874
184cell-cell recognition (GO:0009988)10.9116439
185fusion of sperm to egg plasma membrane (GO:0007342)10.8170751
186male meiosis (GO:0007140)10.0586313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse9.05204403
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.43676799
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.70735605
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.13413079
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.39832191
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01587450
7IGF1R_20145208_ChIP-Seq_DFB_Human2.74576201
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.70047421
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.58619423
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.54305462
11GBX2_23144817_ChIP-Seq_PC3_Human2.52698967
12GATA1_22025678_ChIP-Seq_K562_Human2.50568660
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48245776
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.46441418
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.43665389
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.43665389
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.43665389
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.38236606
19MYC_18940864_ChIP-ChIP_HL60_Human2.34299180
20RNF2_27304074_Chip-Seq_NSC_Mouse2.31705252
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.15551202
22EWS_26573619_Chip-Seq_HEK293_Human2.13080641
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11559800
24RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse2.03881370
25BCAT_22108803_ChIP-Seq_LS180_Human1.99041654
26KAP1_22055183_ChIP-Seq_ESCs_Mouse1.95722630
27EZH2_22144423_ChIP-Seq_EOC_Human1.92910289
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.92806187
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.91722183
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.91032327
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78642345
32CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.76206138
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75072479
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69365160
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68227485
36ZNF274_21170338_ChIP-Seq_K562_Hela1.67180964
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66610425
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.66450473
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.64562759
40TBL1_22424771_ChIP-Seq_293T_Human1.61372158
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58912220
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.56753191
43* OCT4_18555785_Chip-Seq_ESCs_Mouse1.55609610
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52263817
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.50864770
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50366933
47TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.50208704
48RUNX1_26923725_Chip-Seq_HPCs_Mouse1.50005533
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48316026
50TP53_22573176_ChIP-Seq_HFKS_Human1.47806612
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.45722839
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44562794
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.44447843
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44004633
55* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.42359272
56ER_23166858_ChIP-Seq_MCF-7_Human1.41367008
57FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41246984
58ETV1_20927104_ChIP-Seq_GIST48_Human1.40707908
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40330126
60NFYB_21822215_ChIP-Seq_K562_Human1.40065185
61STAT3_23295773_ChIP-Seq_U87_Human1.39267080
62* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39212517
63TCF4_22108803_ChIP-Seq_LS180_Human1.39000614
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.38387978
65PHF8_20622853_ChIP-Seq_HELA_Human1.38308352
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.35836239
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35443713
68* P300_18555785_Chip-Seq_ESCs_Mouse1.34578011
69* CTCF_18555785_Chip-Seq_ESCs_Mouse1.34562079
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.34479766
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.33819570
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33467340
73TCF4_23295773_ChIP-Seq_U87_Human1.32980268
74HOXB7_26014856_ChIP-Seq_BT474_Human1.31457639
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30043130
76P53_22387025_ChIP-Seq_ESCs_Mouse1.28112092
77KDM2B_26808549_Chip-Seq_REH_Human1.27739930
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27602495
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27518303
80CDX2_22108803_ChIP-Seq_LS180_Human1.26798243
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.26053247
82* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25597420
83* GATA3_21867929_ChIP-Seq_TH1_Mouse1.25053279
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24897182
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.24830165
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24593753
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.24253825
88RUNX2_22187159_ChIP-Seq_PCA_Human1.24096233
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.23999281
90* STAT3_18555785_Chip-Seq_ESCs_Mouse1.23688931
91* KLF4_18555785_Chip-Seq_ESCs_Mouse1.23327801
92* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.22838277
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.22679999
94BP1_19119308_ChIP-ChIP_Hs578T_Human1.19950115
95SMAD4_21799915_ChIP-Seq_A2780_Human1.19299491
96CBP_20019798_ChIP-Seq_JUKART_Human1.19025848
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19025848
98HNFA_21074721_ChIP-Seq_CACO-2_Human1.17698265
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.17644898
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17644898
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17210668
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17127479
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.16871108
104* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16344273
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15725750
106STAT1_17558387_ChIP-Seq_HELA_Human1.15525424
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15271208
108FUS_26573619_Chip-Seq_HEK293_Human1.15266780
109VDR_22108803_ChIP-Seq_LS180_Human1.15212737
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.15088005
111RBPJ_21746931_ChIP-Seq_IB4_Human1.14623385
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14509340
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14357159
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14343606
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.13733273
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11342752
117LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10573711
118RXR_22108803_ChIP-Seq_LS180_Human1.09869667
119P300_19829295_ChIP-Seq_ESCs_Human1.09855913
120GATA6_21074721_ChIP-Seq_CACO-2_Human1.09622266
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09524082
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09482550
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09429201
124CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09192427
125E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08402818
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07754866
127NFYA_21822215_ChIP-Seq_K562_Human1.07087942
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05833983
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.05472876
130AR_25329375_ChIP-Seq_VCAP_Human1.04993573
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04823006
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.03729696
133EED_16625203_ChIP-ChIP_MESCs_Mouse1.03694901
134SPI1_26923725_Chip-Seq_HPCs_Mouse1.03624532
135* ZFX_18555785_Chip-Seq_ESCs_Mouse1.03528314
136* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03029527
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03029193
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01543872
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.01540497
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01444473
141AR_20517297_ChIP-Seq_VCAP_Human1.00799867
142ERA_21632823_ChIP-Seq_H3396_Human1.00534037
143STAT1_20625510_ChIP-Seq_HELA_Human0.99639493
144* NMYC_18555785_Chip-Seq_ESCs_Mouse0.99339594
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99148207
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99148207
147PU1_27457419_Chip-Seq_LIVER_Mouse0.99060201
148* E2F1_18555785_Chip-Seq_ESCs_Mouse0.97815727
149SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96951026
150CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96709963
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95957626
152NCOR_22424771_ChIP-Seq_293T_Human0.95680051
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95128184
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.94772657
155GF1_26923725_Chip-Seq_HPCs_Mouse0.94330030
156ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94087953
157HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93563787
158* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93075114
159SOX2_19829295_ChIP-Seq_ESCs_Human0.91900851
160NANOG_19829295_ChIP-Seq_ESCs_Human0.91900851
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91754030
162PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91331989
163GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90710810
164ESET_19884257_ChIP-Seq_ESCs_Mouse0.89813031
165TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89661074
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88862358
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86243704
168FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85854773
169SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85658542
170CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85521893
171E2F1_20622854_ChIP-Seq_HELA_Human0.84853981
172NOTCH1_21737748_ChIP-Seq_TLL_Human0.84795218
173ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84693767
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84214142
175SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.82305208
176LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81983332
177* MYC_18555785_ChIP-Seq_MESCs_Mouse0.81405090
178PHF8_20622854_ChIP-Seq_HELA_Human0.80405792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.36490105
2MP0009384_cardiac_valve_regurgitation5.31924032
3MP0008877_abnormal_DNA_methylation5.20766724
4MP0001929_abnormal_gametogenesis5.02629992
5MP0009046_muscle_twitch4.76633369
6MP0005623_abnormal_meninges_morphology4.68161632
7MP0002653_abnormal_ependyma_morphology4.66729220
8MP0003828_pulmonary_edema4.62045544
9MP0008995_early_reproductive_senescence3.88283686
10MP0002210_abnormal_sex_determination3.78805660
11MP0003567_abnormal_fetal_cardiomyocyte3.46338987
12MP0001145_abnormal_male_reproductive3.31927536
13MP0008057_abnormal_DNA_replication3.00534125
14MP0010386_abnormal_urinary_bladder3.00146143
15MP0003890_abnormal_embryonic-extraembry2.96489662
16MP0000653_abnormal_sex_gland2.94622086
17MP0002161_abnormal_fertility/fecundity2.86435296
18MP0008058_abnormal_DNA_repair2.79195101
19MP0005389_reproductive_system_phenotype2.75725427
20MP0001661_extended_life_span2.61790516
21MP0003119_abnormal_digestive_system2.51013337
22MP0001919_abnormal_reproductive_system2.29113165
23MP0001986_abnormal_taste_sensitivity2.28547565
24MP0004885_abnormal_endolymph2.26082183
25MP0002127_abnormal_cardiovascular_syste2.19759993
26MP0005360_urolithiasis2.18052209
27MP0003942_abnormal_urinary_system2.09466613
28MP0010094_abnormal_chromosome_stability2.07738018
29MP0003315_abnormal_perineum_morphology2.03466546
30MP0009333_abnormal_splenocyte_physiolog2.02415525
31MP0005410_abnormal_fertilization12.0550955
32MP0005646_abnormal_pituitary_gland1.87429985
33MP0003646_muscle_fatigue1.84245669
34MP0003221_abnormal_cardiomyocyte_apopto1.82660294
35MP0002282_abnormal_trachea_morphology1.78292691
36MP0000639_abnormal_adrenal_gland1.74531332
37MP0003115_abnormal_respiratory_system1.63945331
38MP0002837_dystrophic_cardiac_calcinosis1.52023298
39MP0006276_abnormal_autonomic_nervous1.47560366
40MP0003656_abnormal_erythrocyte_physiolo1.34463762
41MP0008007_abnormal_cellular_replicative1.34221495
42MP0001764_abnormal_homeostasis1.30747639
43MP0003936_abnormal_reproductive_system1.28962191
44MP0005167_abnormal_blood-brain_barrier1.24664148
45MP0003136_yellow_coat_color1.23734112
46MP0000538_abnormal_urinary_bladder1.23294085
47MP0001485_abnormal_pinna_reflex1.18864858
48MP0003123_paternal_imprinting1.18780868
49MP0004142_abnormal_muscle_tone1.17107060
50MP0004133_heterotaxia1.15336543
51MP0004084_abnormal_cardiac_muscle1.14546239
52MP0003011_delayed_dark_adaptation1.14073029
53MP0002822_catalepsy1.06124606
54MP0000767_abnormal_smooth_muscle1.04556997
55MP0004808_abnormal_hematopoietic_stem1.00964741
56MP0010307_abnormal_tumor_latency1.00692892
57MP0000427_abnormal_hair_cycle1.00399133
58MP0008775_abnormal_heart_ventricle0.99805223
59MP0005253_abnormal_eye_physiology0.99045578
60MP0010368_abnormal_lymphatic_system0.94526690
61MP0009697_abnormal_copulation0.91856958
62MP0001188_hyperpigmentation0.91477314
63MP0005551_abnormal_eye_electrophysiolog0.90767583
64MP0003699_abnormal_female_reproductive0.90575507
65MP0003111_abnormal_nucleus_morphology0.87608402
66MP0003943_abnormal_hepatobiliary_system0.86622112
67MP0002909_abnormal_adrenal_gland0.86614266
68MP0003693_abnormal_embryo_hatching0.85969292
69MP0000372_irregular_coat_pigmentation0.85561422
70MP0005647_abnormal_sex_gland0.85538950
71MP0001293_anophthalmia0.84455525
72MP0003121_genomic_imprinting0.84130558
73MP0004036_abnormal_muscle_relaxation0.83463445
74MP0000313_abnormal_cell_death0.81021548
75MP0000383_abnormal_hair_follicle0.80924050
76MP0002928_abnormal_bile_duct0.80442284
77MP0002396_abnormal_hematopoietic_system0.79851597
78MP0003763_abnormal_thymus_physiology0.77025713
79MP0003786_premature_aging0.76657492
80MP0001545_abnormal_hematopoietic_system0.75769859
81MP0005397_hematopoietic_system_phenotyp0.75769859
82MP0001727_abnormal_embryo_implantation0.73661089
83MP0009780_abnormal_chondrocyte_physiolo0.72975015
84MP0001544_abnormal_cardiovascular_syste0.71819787
85MP0005385_cardiovascular_system_phenoty0.71819787
86MP0003252_abnormal_bile_duct0.71483177
87MP0001672_abnormal_embryogenesis/_devel0.71164971
88MP0005380_embryogenesis_phenotype0.71164971
89MP0001968_abnormal_touch/_nociception0.70709918
90MP0006072_abnormal_retinal_apoptosis0.70251842
91MP0005085_abnormal_gallbladder_physiolo0.70236278
92MP0004215_abnormal_myocardial_fiber0.69880351
93MP0003984_embryonic_growth_retardation0.67227752
94MP0004233_abnormal_muscle_weight0.66992752
95MP0008789_abnormal_olfactory_epithelium0.66812402
96MP0001765_abnormal_ion_homeostasis0.66534333
97MP0002735_abnormal_chemical_nociception0.66468186
98MP0001119_abnormal_female_reproductive0.66312011
99MP0009379_abnormal_foot_pigmentation0.65784011
100MP0002088_abnormal_embryonic_growth/wei0.65587481
101MP0003633_abnormal_nervous_system0.63853220
102MP0003045_fibrosis0.63675093
103MP0000631_abnormal_neuroendocrine_gland0.61585610
104MP0002736_abnormal_nociception_after0.60209446
105MP0002638_abnormal_pupillary_reflex0.59644009
106MP0001984_abnormal_olfaction0.59554684
107MP0005310_abnormal_salivary_gland0.58720283
108MP0004484_altered_response_of0.58425353
109MP0003077_abnormal_cell_cycle0.57937887
110MP0003937_abnormal_limbs/digits/tail_de0.57713916
111MP0003718_maternal_effect0.57702353
112MP0002009_preneoplasia0.57539391
113MP0005391_vision/eye_phenotype0.56307568
114MP0000013_abnormal_adipose_tissue0.55470013
115MP0008875_abnormal_xenobiotic_pharmacok0.54770154
116MP0005620_abnormal_muscle_contractility0.54094047
117MP0001501_abnormal_sleep_pattern0.54036546
118MP0006292_abnormal_olfactory_placode0.53894676
119MP0008961_abnormal_basal_metabolism0.52020580
120MP0000049_abnormal_middle_ear0.51978523
121MP0005595_abnormal_vascular_smooth0.51750130
122MP0001963_abnormal_hearing_physiology0.51669424
123MP0003938_abnormal_ear_development0.51508436
124MP0001784_abnormal_fluid_regulation0.51480985
125MP0004085_abnormal_heartbeat0.51166355
126MP0000432_abnormal_head_morphology0.49992900
127MP0001730_embryonic_growth_arrest0.49558254
128MP0000703_abnormal_thymus_morphology0.45053587
129MP0002133_abnormal_respiratory_system0.44099700
130MP0005388_respiratory_system_phenotype0.44099700
131MP0002114_abnormal_axial_skeleton0.42318862
132MP0000750_abnormal_muscle_regeneration0.41607984
133MP0005174_abnormal_tail_pigmentation0.38080923
134MP0000647_abnormal_sebaceous_gland0.37093893
135MP0003950_abnormal_plasma_membrane0.36496120
136MP0003631_nervous_system_phenotype0.35174562
137MP0004019_abnormal_vitamin_homeostasis0.35106290
138MP0002398_abnormal_bone_marrow0.34711357
139MP0001324_abnormal_eye_pigmentation0.34218867
140MP0005076_abnormal_cell_differentiation0.31749762
141MP0008569_lethality_at_weaning0.30972552
142MP0003183_abnormal_peptide_metabolism0.30720013
143MP0008872_abnormal_physiological_respon0.30656548
144MP0005266_abnormal_metabolism0.30535273
145MP0002132_abnormal_respiratory_system0.30485354
146MP0003705_abnormal_hypodermis_morpholog0.30323092
147MP0002084_abnormal_developmental_patter0.29688405
148MP0000015_abnormal_ear_pigmentation0.29632590
149MP0006036_abnormal_mitochondrial_physio0.29047895
150MP0003279_aneurysm0.28803747
151MP0000716_abnormal_immune_system0.28422456
152MP0005365_abnormal_bile_salt0.28093581
153MP0005464_abnormal_platelet_physiology0.26469973
154MP0003091_abnormal_cell_migration0.26299586
155MP0002722_abnormal_immune_system0.25590733
156MP0000358_abnormal_cell_content/0.24867998
157MP0000689_abnormal_spleen_morphology0.24251232
158MP0005636_abnormal_mineral_homeostasis0.24028078
159MP0002085_abnormal_embryonic_tissue0.24021057
160MP0006138_congestive_heart_failure0.23555056
161MP0002135_abnormal_kidney_morphology0.23498851
162MP0002080_prenatal_lethality0.23251624
163MP0001697_abnormal_embryo_size0.23107196
164MP0002405_respiratory_system_inflammati0.23022603
165MP0004957_abnormal_blastocyst_morpholog0.22837593
166MP0000609_abnormal_liver_physiology0.22270913
167MP0005319_abnormal_enzyme/_coenzyme0.21652033
168MP0002429_abnormal_blood_cell0.21650649
169MP0000858_altered_metastatic_potential0.21541757
170MP0005000_abnormal_immune_tolerance0.21409107
171MP0002160_abnormal_reproductive_system0.21322601
172MP0004134_abnormal_chest_morphology0.21144799
173MP0004811_abnormal_neuron_physiology0.20811561
174MP0000465_gastrointestinal_hemorrhage0.20780119

Predicted human phenotypes

RankGene SetZ-score
1Testicular neoplasm (HP:0010788)8.63189396
2Abnormal respiratory motile cilium physiology (HP:0012261)8.43033871
3Absent/shortened dynein arms (HP:0200106)7.76360939
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.76360939
5Hypoplastic left heart (HP:0004383)7.50435669
6Abnormal ciliary motility (HP:0012262)7.49791847
7Mesangial abnormality (HP:0001966)7.16107296
8Rhinitis (HP:0012384)6.96705834
9Nasal polyposis (HP:0100582)6.11298440
10Hypoplastic heart (HP:0001961)6.02069190
11Abnormal sex determination (HP:0012244)5.74209040
12Sex reversal (HP:0012245)5.74209040
13Tongue fasciculations (HP:0001308)5.66002704
14Chronic bronchitis (HP:0004469)5.58267415
15Transposition of the great arteries (HP:0001669)5.44594402
16Abnormal connection of the cardiac segments (HP:0011545)5.44594402
17Abnormal ventriculo-arterial connection (HP:0011563)5.44594402
18Abnormal respiratory epithelium morphology (HP:0012253)5.42547835
19Abnormal respiratory motile cilium morphology (HP:0005938)5.42547835
20Germ cell neoplasia (HP:0100728)5.17041846
21Muscle fibrillation (HP:0010546)5.11660265
22Abnormality of the nasal mucosa (HP:0000433)5.06113421
23Abnormal spermatogenesis (HP:0008669)4.65678329
24Bronchitis (HP:0012387)4.46273277
25Male pseudohermaphroditism (HP:0000037)4.43220825
26Shoulder girdle muscle weakness (HP:0003547)4.41107615
27Bronchiectasis (HP:0002110)4.20071993
28Abnormality of the lower motor neuron (HP:0002366)4.13816129
29Urinary bladder sphincter dysfunction (HP:0002839)4.10848013
30Microglossia (HP:0000171)4.09495997
31Female pseudohermaphroditism (HP:0010458)4.08282184
32Pancreatic fibrosis (HP:0100732)4.05120843
33Infertility (HP:0000789)4.04451906
34Nephronophthisis (HP:0000090)3.92858603
35Azoospermia (HP:0000027)3.89947518
36Abnormal lung lobation (HP:0002101)3.86957500
37Male infertility (HP:0003251)3.79748465
38Volvulus (HP:0002580)3.78987173
39Periauricular skin pits (HP:0100277)3.78560596
40Preauricular pit (HP:0004467)3.78560596
41Tubular atrophy (HP:0000092)3.78066825
42Recurrent bronchitis (HP:0002837)3.71610519
43Molar tooth sign on MRI (HP:0002419)3.70411896
44Abnormality of midbrain morphology (HP:0002418)3.70411896
45Impaired vibration sensation in the lower limbs (HP:0002166)3.69177409
46Rimmed vacuoles (HP:0003805)3.65369438
47Primary adrenal insufficiency (HP:0008207)3.30173186
48Spontaneous abortion (HP:0005268)3.28454919
49Anomalous pulmonary venous return (HP:0010772)3.26567206
50Slow saccadic eye movements (HP:0000514)3.19929200
51J-shaped sella turcica (HP:0002680)3.17709884
52Hypoplasia of the uterus (HP:0000013)3.15817397
53Metaphyseal dysplasia (HP:0100255)3.13602222
54Recurrent sinusitis (HP:0011108)3.11916404
55Ovarian neoplasm (HP:0100615)3.11058530
56Abnormality of saccadic eye movements (HP:0000570)3.09846709
57Median cleft lip (HP:0000161)3.08712358
58Hyperventilation (HP:0002883)3.05879483
59Recurrent otitis media (HP:0000403)3.01183527
60Absent frontal sinuses (HP:0002688)2.90836216
61Tubulointerstitial fibrosis (HP:0005576)2.85005163
62Abnormality of the pulmonary veins (HP:0011718)2.83311795
63Impaired vibratory sensation (HP:0002495)2.80021475
64Abnormality of the renal medulla (HP:0100957)2.75213254
65Urinary urgency (HP:0000012)2.72812429
66Abnormality of male internal genitalia (HP:0000022)2.71006834
67Polydipsia (HP:0001959)2.63889681
68Abnormal drinking behavior (HP:0030082)2.63889681
69Upper motor neuron abnormality (HP:0002127)2.62418168
70Medial flaring of the eyebrow (HP:0010747)2.62116683
71Congenital hepatic fibrosis (HP:0002612)2.61692978
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.61547991
73Chronic hepatic failure (HP:0100626)2.56461656
74Optic nerve hypoplasia (HP:0000609)2.55626273
75Facial cleft (HP:0002006)2.53653147
76Proximal placement of thumb (HP:0009623)2.51618185
77Skin pits (HP:0100276)2.50374878
78Osteomalacia (HP:0002749)2.49154998
79Fibular hypoplasia (HP:0003038)2.41627181
80Aplasia/hypoplasia of the uterus (HP:0008684)2.40257451
81Amyotrophic lateral sclerosis (HP:0007354)2.39391827
82Abnormality of ocular smooth pursuit (HP:0000617)2.38852529
83Abnormal biliary tract physiology (HP:0012439)2.38318182
84Bile duct proliferation (HP:0001408)2.38318182
85Postaxial foot polydactyly (HP:0001830)2.37385480
86Focal segmental glomerulosclerosis (HP:0000097)2.34462239
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31686574
88Degeneration of the lateral corticospinal tracts (HP:0002314)2.31686574
89Chronic sinusitis (HP:0011109)2.31586496
90Deviation of the thumb (HP:0009603)2.29864187
91Impaired smooth pursuit (HP:0007772)2.28587269
92Decreased central vision (HP:0007663)2.28323968
93Urethral obstruction (HP:0000796)2.27788032
94Genetic anticipation (HP:0003743)2.26988160
95Preaxial foot polydactyly (HP:0001841)2.24887380
96Abnormality of the peritoneum (HP:0002585)2.24273621
97Abnormality of lateral ventricle (HP:0030047)2.23944934
98Tubulointerstitial abnormality (HP:0001969)2.23937968
9911 pairs of ribs (HP:0000878)2.22162749
100Short ribs (HP:0000773)2.14551910
101Abnormality of the anterior horn cell (HP:0006802)2.10208663
102Degeneration of anterior horn cells (HP:0002398)2.10208663
103Spastic paraplegia (HP:0001258)2.09535668
104Deformed sella turcica (HP:0002681)2.08637571
105Limb ataxia (HP:0002070)2.06734272
106Spastic gait (HP:0002064)2.06024600
107Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.05306115
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05159173
109Glomerulosclerosis (HP:0000096)2.04860856
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03472282
111Short thorax (HP:0010306)2.03209265
112Paraplegia (HP:0010550)2.01453967
113Occipital encephalocele (HP:0002085)2.01108936
114Congenital diaphragmatic hernia (HP:0000776)2.00878179
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8584206
116Gonadal dysgenesis (HP:0000133)10.6681917
117Nephroblastoma (Wilms tumor) (HP:0002667)1.94886564
118Abnormality of the vocal cords (HP:0008777)1.91945199
119Oculomotor apraxia (HP:0000657)1.91112056
120Renal dysplasia (HP:0000110)1.88138527
121Lower limb muscle weakness (HP:0007340)1.85958550
122Short tibia (HP:0005736)1.85396572
123Hypocalcemia (HP:0002901)1.80026952
124Abnormality of the corticospinal tract (HP:0002492)1.78256147
125Embryonal renal neoplasm (HP:0011794)1.77651216
126Gaze-evoked nystagmus (HP:0000640)1.76212687
127Primary amenorrhea (HP:0000786)1.74582090
128Childhood onset (HP:0011463)1.74464680
129Aplasia/Hypoplasia of the fibula (HP:0006492)1.71513862
130Cystic liver disease (HP:0006706)1.70788789
131Mediastinal lymphadenopathy (HP:0100721)1.68480324
132Postaxial hand polydactyly (HP:0001162)1.68288776
133Pancreatic cysts (HP:0001737)1.67215510
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.66510949
135Morphological abnormality of the pyramidal tract (HP:0002062)1.66360922
136Fasciculations (HP:0002380)1.64908434
137Polyuria (HP:0000103)1.64889441
138Abnormality of the renal cortex (HP:0011035)1.60808854
139Embryonal neoplasm (HP:0002898)1.60807847
140True hermaphroditism (HP:0010459)1.60432203
141Myelomeningocele (HP:0002475)1.60426641
142Abnormality of renal excretion (HP:0011036)1.59621009
143Impaired proprioception (HP:0010831)1.59460113
144Hoarse voice (HP:0001609)1.57645756
145Tetralogy of Fallot (HP:0001636)1.57366731
146Neoplasm of the liver (HP:0002896)1.56947649
147Hydroureter (HP:0000072)1.56734243
148Selective tooth agenesis (HP:0001592)1.56303473
149Abnormal urine output (HP:0012590)1.56110757
150Nephropathy (HP:0000112)1.55828541
151Cone-rod dystrophy (HP:0000548)1.54839066
152Abnormality of the frontal sinuses (HP:0002687)1.54622284
153Tachypnea (HP:0002789)1.54489421
154Abnormality of secondary sexual hair (HP:0009888)1.52732445
155Abnormality of the axillary hair (HP:0100134)1.52732445
156Cheilitis (HP:0100825)1.52591632
157Malnutrition (HP:0004395)1.51997691
158Abnormal rod and cone electroretinograms (HP:0008323)1.51377306
159Pseudobulbar signs (HP:0002200)1.51160365
160Supernumerary spleens (HP:0009799)1.51040536
161Delayed gross motor development (HP:0002194)1.50206083
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.47582422
163Stage 5 chronic kidney disease (HP:0003774)1.47015212
164Progressive cerebellar ataxia (HP:0002073)1.46988558
165Complete atrioventricular canal defect (HP:0001674)1.46350880
166Abnormal pancreas size (HP:0012094)1.45139330
167Retinal dysplasia (HP:0007973)1.42762443
168Gonadotropin excess (HP:0000837)1.41128579
169Sensory axonal neuropathy (HP:0003390)1.38488373
170Prominent supraorbital ridges (HP:0000336)1.38229995
171Clitoromegaly (HP:0000057)1.37758021
172Progressive inability to walk (HP:0002505)1.37657383
173Atrioventricular canal defect (HP:0006695)1.36377324
174Premature ovarian failure (HP:0008209)1.35691481
175Bulbar palsy (HP:0001283)1.34710371
176Chromosomal breakage induced by crosslinking agents (HP:0003221)1.33932033
177Limb-girdle muscle weakness (HP:0003325)1.33112453
178Glomerulopathy (HP:0100820)1.32108864
179Papilledema (HP:0001085)1.32103035
180Concave nail (HP:0001598)1.31908427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.31444171
2PDK46.31444171
3TIE15.55801734
4PDK24.12640714
5RIPK14.10962067
6CDK124.01962270
7MAP2K73.94188769
8PLK43.84955485
9PTK2B3.74997384
10WEE13.47576903
11BRSK23.11536164
12STK393.00810701
13WNK42.97294935
14PNCK2.85458721
15BRD42.83283484
16TESK12.41358411
17PINK12.38248555
18BMPR1B2.28311584
19NLK2.17030423
20GRK12.11020253
21NUAK12.00154858
22ZAP701.86012097
23FRK1.82083041
24PLK21.76654176
25MAP3K41.76108715
26FGR1.70639932
27TNIK1.69027566
28BRSK11.63255624
29TNK21.57891749
30NEK21.53802316
31LMTK21.50899781
32STK101.46431535
33PRKD31.44560179
34STK38L1.38458597
35STK381.35881233
36SCYL21.30608862
37STK161.24736977
38MAP3K61.22011045
39SRPK11.20406068
40NTRK31.18178340
41SGK21.16548587
42CSNK1G11.16088058
43TRIM281.08297037
44PDK11.01157144
45TLK11.00415682
46EPHB10.97169356
47LATS20.96780033
48WNK30.95936584
49SGK2230.95770492
50SGK4940.95770492
51NEK10.94858412
52ZAK0.93363423
53DYRK30.93144440
54CCNB10.92577085
55VRK10.92179541
56CDC70.92125090
57WNK10.86900457
58ACVR1B0.86594775
59ATR0.85618180
60TTK0.83097711
61CHEK20.81977482
62ADRBK20.80414089
63PKN20.74435708
64MARK30.74239216
65SGK10.71812384
66PRKCE0.70731208
67CDK80.68477341
68ICK0.67408709
69MAP3K10.65274101
70PLK10.64114942
71RIPK40.63698603
72TEC0.62962190
73CHEK10.62831336
74MKNK20.62790213
75MAP2K40.62663122
76KDR0.60495796
77MAPK130.59162947
78OBSCN0.58042957
79IRAK30.57011191
80MAP2K60.54809922
81OXSR10.54733852
82PIM10.53588029
83TYRO30.52373258
84PRKACG0.52253036
85EEF2K0.50209428
86CASK0.48816175
87MET0.48333801
88CSF1R0.47327913
89PASK0.46904804
90FES0.46893330
91BMX0.45473748
92BLK0.44894157
93PRKACA0.44124219
94EIF2AK30.43909782
95CDK190.43720729
96ATM0.43610438
97PTK60.43422021
98TESK20.43399784
99NEK90.43298164
100PDGFRB0.43063443
101TGFBR10.42574625
102KIT0.41748465
103PRKCI0.41000056
104IGF1R0.40778545
105TTN0.40359956
106PDPK10.40194480
107CDK70.39022099
108PRKD20.38742469
109TAOK30.37619730
110STK110.37425495
111STK30.36208837
112SGK30.36175600
113PTK20.35765052
114PIK3CA0.34837766
115STK240.34485255
116PRKDC0.33716431
117EPHA40.33534696
118TGFBR20.33302581
119AURKA0.32792121
120MKNK10.32517027
121PRKG20.31895205
122CDK20.31198780
123SYK0.31084570
124ROCK10.30834586
125TAOK10.29462769
126CSNK2A20.29321078
127ADRBK10.28396434
128TRPM70.27960846
129CSNK1G30.27797478
130MAP3K100.27735880
131STK40.27451869
132PRKCD0.27021997
133PRKG10.26268632
134BUB10.26077748
135JAK30.25943199
136RPS6KA30.25918296
137EGFR0.25671518
138CDK60.25216426
139CDK10.24575277
140RPS6KB10.23329138
141PRKCG0.22278823
142YES10.21620205
143MAPK40.20301551
144MAPK100.19907074
145PAK10.19741135
146MAPK80.19136550
147PRKCQ0.18759989
148MAP3K20.18470744
149CSNK2A10.17784235
150PRKCH0.16293595
151PLK30.15806103
152AURKB0.14962267
153CDK40.14426966
154MAPK10.14174595
155DYRK1A0.12999692
156GSK3B0.12530352
157MAP3K30.12018103
158BTK0.11167121
159MINK10.11012329
160PIM20.10859109
161DYRK1B0.10638643

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose phosphate pathway_Homo sapiens_hsa000305.97585675
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.16674042
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.02052558
4Renin-angiotensin system_Homo sapiens_hsa046143.99442101
5Basal transcription factors_Homo sapiens_hsa030223.93960352
6Lysine degradation_Homo sapiens_hsa003103.58221114
7Mismatch repair_Homo sapiens_hsa034303.02557647
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90763442
9Vitamin B6 metabolism_Homo sapiens_hsa007502.87540115
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.84986304
11Hedgehog signaling pathway_Homo sapiens_hsa043402.56076656
12Fanconi anemia pathway_Homo sapiens_hsa034602.54165281
13Biosynthesis of amino acids_Homo sapiens_hsa012302.46456662
14Pyruvate metabolism_Homo sapiens_hsa006202.35155447
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.24823465
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.19830623
17Homologous recombination_Homo sapiens_hsa034402.17196207
18Propanoate metabolism_Homo sapiens_hsa006402.08289148
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07277993
20One carbon pool by folate_Homo sapiens_hsa006702.03605481
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.98453523
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.88476001
23RNA polymerase_Homo sapiens_hsa030201.88261116
24Huntingtons disease_Homo sapiens_hsa050161.84263389
25Carbon metabolism_Homo sapiens_hsa012001.82776590
26Systemic lupus erythematosus_Homo sapiens_hsa053221.77937067
27Tryptophan metabolism_Homo sapiens_hsa003801.67619836
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57936787
29Cell cycle_Homo sapiens_hsa041101.56833232
30Basal cell carcinoma_Homo sapiens_hsa052171.53586940
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.51118862
32Fatty acid biosynthesis_Homo sapiens_hsa000611.49075227
33Chemical carcinogenesis_Homo sapiens_hsa052041.47075346
34Fatty acid elongation_Homo sapiens_hsa000621.45318763
35Oocyte meiosis_Homo sapiens_hsa041141.44097625
36RNA transport_Homo sapiens_hsa030131.42553844
37Ribosome_Homo sapiens_hsa030101.41451167
38Glucagon signaling pathway_Homo sapiens_hsa049221.39519210
39TGF-beta signaling pathway_Homo sapiens_hsa043501.37181954
40Folate biosynthesis_Homo sapiens_hsa007901.34497851
41Linoleic acid metabolism_Homo sapiens_hsa005911.29043138
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23770622
43Salivary secretion_Homo sapiens_hsa049701.23077370
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22004000
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.13120725
46RNA degradation_Homo sapiens_hsa030181.10738602
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10289994
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.09607028
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09172288
50Butanoate metabolism_Homo sapiens_hsa006501.04057818
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.03987177
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.03345579
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03111034
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99231294
55N-Glycan biosynthesis_Homo sapiens_hsa005100.98574380
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97222622
57Peroxisome_Homo sapiens_hsa041460.96287707
58Glycerolipid metabolism_Homo sapiens_hsa005610.95698565
59Viral carcinogenesis_Homo sapiens_hsa052030.94057580
60Spliceosome_Homo sapiens_hsa030400.91534981
61p53 signaling pathway_Homo sapiens_hsa041150.89198602
62Fat digestion and absorption_Homo sapiens_hsa049750.88087153
63Fatty acid degradation_Homo sapiens_hsa000710.86768270
64Ovarian steroidogenesis_Homo sapiens_hsa049130.84915946
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83418554
66Purine metabolism_Homo sapiens_hsa002300.83107909
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81922565
68Insulin secretion_Homo sapiens_hsa049110.79942733
69mRNA surveillance pathway_Homo sapiens_hsa030150.79804944
70Selenocompound metabolism_Homo sapiens_hsa004500.79074347
71Base excision repair_Homo sapiens_hsa034100.78317404
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75238864
73Sulfur metabolism_Homo sapiens_hsa009200.75215369
74Hippo signaling pathway_Homo sapiens_hsa043900.74922521
75Arginine and proline metabolism_Homo sapiens_hsa003300.74663649
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74191734
77Amphetamine addiction_Homo sapiens_hsa050310.73697377
78DNA replication_Homo sapiens_hsa030300.69659095
79Wnt signaling pathway_Homo sapiens_hsa043100.65592815
80Caffeine metabolism_Homo sapiens_hsa002320.64887872
81Nicotine addiction_Homo sapiens_hsa050330.63711700
82Mineral absorption_Homo sapiens_hsa049780.61533176
83Cardiac muscle contraction_Homo sapiens_hsa042600.61467972
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.61315717
85Herpes simplex infection_Homo sapiens_hsa051680.60871410
86Sulfur relay system_Homo sapiens_hsa041220.59588796
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58834898
88Protein export_Homo sapiens_hsa030600.56156520
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56087469
90Pancreatic secretion_Homo sapiens_hsa049720.55887989
91Renin secretion_Homo sapiens_hsa049240.55024017
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54316341
93Non-homologous end-joining_Homo sapiens_hsa034500.54059465
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53209785
95Cocaine addiction_Homo sapiens_hsa050300.52678102
96PPAR signaling pathway_Homo sapiens_hsa033200.51539386
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49889195
98Salmonella infection_Homo sapiens_hsa051320.49594036
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49517669
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49214391
101Dorso-ventral axis formation_Homo sapiens_hsa043200.48877185
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47543251
103beta-Alanine metabolism_Homo sapiens_hsa004100.47195250
104Metabolic pathways_Homo sapiens_hsa011000.46249489
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43008105
106MAPK signaling pathway_Homo sapiens_hsa040100.42966465
107Serotonergic synapse_Homo sapiens_hsa047260.42184498
108Alcoholism_Homo sapiens_hsa050340.41705463
109cAMP signaling pathway_Homo sapiens_hsa040240.41698885
110Phototransduction_Homo sapiens_hsa047440.40516805
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.39197328
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38429311
113Fatty acid metabolism_Homo sapiens_hsa012120.38023480
114Proteasome_Homo sapiens_hsa030500.38001602
115Bile secretion_Homo sapiens_hsa049760.37135205
116Antigen processing and presentation_Homo sapiens_hsa046120.36730615
117Ether lipid metabolism_Homo sapiens_hsa005650.34412642
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34250667
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33477545
120Olfactory transduction_Homo sapiens_hsa047400.31375158
121ABC transporters_Homo sapiens_hsa020100.31359640
122Pyrimidine metabolism_Homo sapiens_hsa002400.31202346
123Fructose and mannose metabolism_Homo sapiens_hsa000510.29469657
124Rap1 signaling pathway_Homo sapiens_hsa040150.28095941
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.24430080
126Epstein-Barr virus infection_Homo sapiens_hsa051690.22160193
127Arachidonic acid metabolism_Homo sapiens_hsa005900.22108768
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20861906
129Endocytosis_Homo sapiens_hsa041440.20151323
130Long-term potentiation_Homo sapiens_hsa047200.19144939
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19109400
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18369583
133Calcium signaling pathway_Homo sapiens_hsa040200.17187744
134Taste transduction_Homo sapiens_hsa047420.17186043
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16639073
136Complement and coagulation cascades_Homo sapiens_hsa046100.16474735
137Sphingolipid metabolism_Homo sapiens_hsa006000.13101289
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12054742
139Retinol metabolism_Homo sapiens_hsa008300.11550431
140Nucleotide excision repair_Homo sapiens_hsa034200.10750797
141AMPK signaling pathway_Homo sapiens_hsa041520.10020944
142HTLV-I infection_Homo sapiens_hsa051660.09861144
143Shigellosis_Homo sapiens_hsa051310.09731877
144Glutathione metabolism_Homo sapiens_hsa004800.09695337
145Estrogen signaling pathway_Homo sapiens_hsa049150.09240980
146Vitamin digestion and absorption_Homo sapiens_hsa049770.09071838
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08859306
148Thyroid hormone synthesis_Homo sapiens_hsa049180.07303699
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.07145267
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06191802

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