MAGEA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.61823000
2synaptonemal complex assembly (GO:0007130)8.35109942
3DNA methylation involved in gamete generation (GO:0043046)7.92738898
4synaptonemal complex organization (GO:0070193)7.65604197
5meiotic nuclear division (GO:0007126)6.00323842
6chromosome organization involved in meiosis (GO:0070192)5.81133745
7male meiosis (GO:0007140)5.76269172
8male meiosis I (GO:0007141)5.67262387
9regulation of meiosis I (GO:0060631)5.67039579
10proteasome assembly (GO:0043248)5.55835527
11meiosis I (GO:0007127)5.39062419
12purine nucleobase biosynthetic process (GO:0009113)5.38280541
13ribosome assembly (GO:0042255)4.79828207
14nucleobase biosynthetic process (GO:0046112)4.73563731
15meiotic cell cycle process (GO:1903046)4.68916445
16positive regulation of translational initiation (GO:0045948)4.60587029
17DNA replication checkpoint (GO:0000076)4.51685398
18reciprocal DNA recombination (GO:0035825)4.42260493
19reciprocal meiotic recombination (GO:0007131)4.42260493
20DNA synthesis involved in DNA repair (GO:0000731)4.41835984
21protein K6-linked ubiquitination (GO:0085020)4.36663059
22attachment of spindle microtubules to kinetochore (GO:0008608)4.29803795
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.23230670
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.16383079
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.16194027
26oocyte maturation (GO:0001556)4.13385484
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.12769483
28blastocyst development (GO:0001824)4.12339208
29positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.10879944
30ribosome biogenesis (GO:0042254)4.01714657
31oogenesis (GO:0048477)3.92335215
32mitotic metaphase plate congression (GO:0007080)3.92235829
33positive regulation of ligase activity (GO:0051351)3.83337885
34mitotic spindle assembly checkpoint (GO:0007094)3.79132457
35kinetochore assembly (GO:0051382)3.77728997
36folic acid metabolic process (GO:0046655)3.75198622
37regulation of cellular amino acid metabolic process (GO:0006521)3.71367939
38negative regulation of ligase activity (GO:0051352)3.70862477
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70862477
40mitotic spindle checkpoint (GO:0071174)3.70710978
41negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.68808619
42negative regulation of sister chromatid segregation (GO:0033046)3.68808619
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.68808619
44negative regulation of mitotic sister chromatid segregation (GO:0033048)3.68808619
45spindle assembly checkpoint (GO:0071173)3.68784454
46spindle checkpoint (GO:0031577)3.67813578
47negative regulation of chromosome segregation (GO:0051985)3.67789892
48regulation of mitochondrial translation (GO:0070129)3.67361633
49rRNA modification (GO:0000154)3.64504581
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.59342734
51termination of RNA polymerase III transcription (GO:0006386)3.59342734
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.58737203
53DNA alkylation (GO:0006305)3.57311113
54DNA methylation (GO:0006306)3.57311113
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.56997093
56resolution of meiotic recombination intermediates (GO:0000712)3.56026378
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.55661544
58signal transduction involved in DNA damage checkpoint (GO:0072422)3.55661544
59kinetochore organization (GO:0051383)3.55231554
60gene silencing by RNA (GO:0031047)3.54606436
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54228699
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54228699
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54228699
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.53923406
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52114645
66positive regulation of meiosis (GO:0045836)3.50774577
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.50297712
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.50297712
69signal transduction involved in cell cycle checkpoint (GO:0072395)3.49363979
70positive regulation of meiotic cell cycle (GO:0051446)3.44108168
717-methylguanosine mRNA capping (GO:0006370)3.41645560
72termination of RNA polymerase I transcription (GO:0006363)3.41291505
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40688883
74formation of translation preinitiation complex (GO:0001731)3.40356958
75regulation of chromosome segregation (GO:0051983)3.37973208
76folic acid transport (GO:0015884)3.37817504
77cellular protein catabolic process (GO:0044257)3.35930708
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.34573867
79regulation of ligase activity (GO:0051340)3.33225268
80regulation of spindle organization (GO:0090224)3.33076123
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32200880
827-methylguanosine RNA capping (GO:0009452)3.31672123
83RNA capping (GO:0036260)3.31672123
84transcription from RNA polymerase I promoter (GO:0006360)3.30180460
85chromatin remodeling at centromere (GO:0031055)3.29511046
86metaphase plate congression (GO:0051310)3.29464989
87ribonucleoprotein complex biogenesis (GO:0022613)3.28837965
88DNA replication initiation (GO:0006270)3.28295913
89maturation of SSU-rRNA (GO:0030490)3.28166675
90regulation of sister chromatid segregation (GO:0033045)3.26707511
91regulation of mitotic sister chromatid separation (GO:0010965)3.26707511
92regulation of mitotic sister chromatid segregation (GO:0033047)3.26707511
93meiotic chromosome segregation (GO:0045132)3.25310169
94protein-cofactor linkage (GO:0018065)3.25099786
95negative regulation of meiosis (GO:0045835)3.24201301
96regulation of glucokinase activity (GO:0033131)3.23461828
97regulation of hexokinase activity (GO:1903299)3.23461828
98DNA replication-dependent nucleosome assembly (GO:0006335)3.21646011
99DNA replication-dependent nucleosome organization (GO:0034723)3.21646011
100histone exchange (GO:0043486)3.20528593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.67284245
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.16963359
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.15886625
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01663127
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99133302
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.80111859
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.77744060
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.67745858
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64585251
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.47575717
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.45545788
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.37025897
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15486655
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94909726
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82604948
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76455745
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76325862
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75267947
19VDR_23849224_ChIP-Seq_CD4+_Human2.53136717
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52047929
21AR_21909140_ChIP-Seq_LNCAP_Human2.46157359
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43708071
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33662367
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19264244
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15605564
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.15341128
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13616977
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10371348
29DCP1A_22483619_ChIP-Seq_HELA_Human2.09972560
30XRN2_22483619_ChIP-Seq_HELA_Human2.09797802
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08419948
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07283560
33GABP_19822575_ChIP-Seq_HepG2_Human2.01493460
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95926944
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94901830
36FOXP3_21729870_ChIP-Seq_TREG_Human1.87475274
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.82893184
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79215624
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.73073012
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68232995
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68232995
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68232995
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66972739
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63471329
45TTF2_22483619_ChIP-Seq_HELA_Human1.61415929
46ELK1_19687146_ChIP-ChIP_HELA_Human1.59724910
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55020876
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54773097
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50559627
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48084491
51KDM5A_27292631_Chip-Seq_BREAST_Human1.47908965
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45396381
53ZNF263_19887448_ChIP-Seq_K562_Human1.41029320
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.38507633
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38098640
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33079542
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31851596
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31387772
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29315822
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27262755
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21579447
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.12579717
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09545417
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06736670
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05644780
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05261991
67TFEB_21752829_ChIP-Seq_HELA_Human1.01797212
68SALL1_21062744_ChIP-ChIP_HESCs_Human0.99440419
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98434201
70HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96954197
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94337243
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93448801
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90909759
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90600185
75CIITA_25753668_ChIP-Seq_RAJI_Human0.89786095
76TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89390721
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88858504
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88573822
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88254741
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86849753
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85945393
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82357153
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.81314037
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80363979
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79240376
86TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78586752
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78516032
88MYC_18940864_ChIP-ChIP_HL60_Human0.77907462
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77139832
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76804172
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.76602971
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75892874
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.74908283
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.74272280
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71444018
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70933692
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69373759
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.68272444
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67453121
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.66602056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.62393996
2MP0003693_abnormal_embryo_hatching5.31092220
3MP0003111_abnormal_nucleus_morphology4.46647446
4MP0003786_premature_aging4.31202649
5MP0008995_early_reproductive_senescence3.99896933
6MP0008058_abnormal_DNA_repair3.89189171
7MP0004957_abnormal_blastocyst_morpholog3.73232420
8MP0010094_abnormal_chromosome_stability3.67655354
9MP0002210_abnormal_sex_determination3.57131309
10MP0003718_maternal_effect3.26419109
11MP0003077_abnormal_cell_cycle3.08265080
12MP0001145_abnormal_male_reproductive2.94009128
13MP0003123_paternal_imprinting2.93204528
14MP0001929_abnormal_gametogenesis2.88356489
15MP0008057_abnormal_DNA_replication2.66486211
16MP0000653_abnormal_sex_gland2.57497554
17MP0008932_abnormal_embryonic_tissue2.39472663
18MP0003698_abnormal_male_reproductive2.17133649
19MP0003941_abnormal_skin_development2.09584595
20MP0008007_abnormal_cellular_replicative2.04270737
21MP0008260_abnormal_autophagy2.02135305
22MP0009840_abnormal_foam_cell1.95454943
23MP0001730_embryonic_growth_arrest1.94324534
24MP0003878_abnormal_ear_physiology1.77526389
25MP0005377_hearing/vestibular/ear_phenot1.77526389
26MP0003315_abnormal_perineum_morphology1.57621501
27MP0004084_abnormal_cardiac_muscle1.47466429
28MP0000350_abnormal_cell_proliferation1.41778571
29MP0002161_abnormal_fertility/fecundity1.41356394
30MP0005395_other_phenotype1.41202494
31MP0003221_abnormal_cardiomyocyte_apopto1.37437387
32MP0001661_extended_life_span1.37390780
33MP0001542_abnormal_bone_strength1.36320740
34MP0001119_abnormal_female_reproductive1.28489728
35MP0005380_embryogenesis_phenotype1.27758768
36MP0001672_abnormal_embryogenesis/_devel1.27758768
37MP0002160_abnormal_reproductive_system1.23168464
38MP0002396_abnormal_hematopoietic_system1.19217238
39MP0009333_abnormal_splenocyte_physiolog1.18709921
40MP0001697_abnormal_embryo_size1.16649750
41MP0003186_abnormal_redox_activity1.16339788
42MP0002080_prenatal_lethality1.12660811
43MP0005389_reproductive_system_phenotype1.11257415
44MP0003984_embryonic_growth_retardation1.10180198
45MP0004019_abnormal_vitamin_homeostasis1.07108185
46MP0003699_abnormal_female_reproductive1.06909617
47MP0010352_gastrointestinal_tract_polyps1.06285349
48MP0002088_abnormal_embryonic_growth/wei1.04948142
49MP0009672_abnormal_birth_weight1.01923075
50MP0002085_abnormal_embryonic_tissue1.01092069
51MP0004808_abnormal_hematopoietic_stem1.00459270
52MP0000313_abnormal_cell_death0.97608784
53MP0002876_abnormal_thyroid_physiology0.92934299
54MP0006036_abnormal_mitochondrial_physio0.92615321
55MP0003646_muscle_fatigue0.86031917
56MP0010307_abnormal_tumor_latency0.83696091
57MP0001919_abnormal_reproductive_system0.82241456
58MP0006035_abnormal_mitochondrial_morpho0.80108654
59MP0002086_abnormal_extraembryonic_tissu0.78909144
60MP0003567_abnormal_fetal_cardiomyocyte0.78304900
61MP0005670_abnormal_white_adipose0.76934066
62MP0001727_abnormal_embryo_implantation0.76550334
63MP0002084_abnormal_developmental_patter0.76410026
64MP0002019_abnormal_tumor_incidence0.74557735
65MP0001986_abnormal_taste_sensitivity0.72248851
66MP0005332_abnormal_amino_acid0.71825027
67MP0001756_abnormal_urination0.70605929
68MP0003936_abnormal_reproductive_system0.69743285
69MP0004197_abnormal_fetal_growth/weight/0.67098141
70MP0005384_cellular_phenotype0.67020186
71MP0009703_decreased_birth_body0.66498585
72MP0000358_abnormal_cell_content/0.65398076
73MP0005621_abnormal_cell_physiology0.64775585
74MP0003121_genomic_imprinting0.63058318
75MP0000647_abnormal_sebaceous_gland0.62158400
76MP0001293_anophthalmia0.59618022
77MP0003879_abnormal_hair_cell0.57758412
78MP0002269_muscular_atrophy0.56767918
79MP0004036_abnormal_muscle_relaxation0.55998056
80MP0005451_abnormal_body_composition0.53647586
81MP0004215_abnormal_myocardial_fiber0.53062394
82MP0009697_abnormal_copulation0.52423074
83MP0000750_abnormal_muscle_regeneration0.51090905
84MP0003119_abnormal_digestive_system0.50349084
85MP0000428_abnormal_craniofacial_morphol0.49659425
86MP0000627_abnormal_mammary_gland0.48874103
87MP0006292_abnormal_olfactory_placode0.48596897
88MP0005367_renal/urinary_system_phenotyp0.47186082
89MP0000516_abnormal_urinary_system0.47186082
90MP0002139_abnormal_hepatobiliary_system0.46273508
91MP0003938_abnormal_ear_development0.46005357
92MP0000383_abnormal_hair_follicle0.45194739
93MP0003195_calcinosis0.44270562
94MP0001545_abnormal_hematopoietic_system0.43004756
95MP0005397_hematopoietic_system_phenotyp0.43004756
96MP0003937_abnormal_limbs/digits/tail_de0.42984737
97MP0006138_congestive_heart_failure0.42548289
98MP0001764_abnormal_homeostasis0.42039252
99MP0003632_abnormal_nervous_system0.38503283
100MP0001853_heart_inflammation0.37761610

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)7.93816887
2Abnormal spermatogenesis (HP:0008669)7.24749186
3Breast hypoplasia (HP:0003187)5.49134781
4Carpal bone hypoplasia (HP:0001498)5.24585916
5Birth length less than 3rd percentile (HP:0003561)4.58010812
6Cerebral hypomyelination (HP:0006808)4.26916090
7Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.87334742
8Rough bone trabeculation (HP:0100670)3.86404612
9Aplasia/Hypoplasia involving the musculature (HP:0001460)3.64981992
10Shoulder girdle muscle weakness (HP:0003547)3.51661865
11Patellar aplasia (HP:0006443)3.47277344
12Aplasia/Hypoplasia of the patella (HP:0006498)3.43416574
13Absent radius (HP:0003974)3.41572566
14Ureteral duplication (HP:0000073)3.28090940
15Impulsivity (HP:0100710)3.25442893
16Aplasia involving forearm bones (HP:0009822)3.20273064
17Absent forearm bone (HP:0003953)3.20273064
18Progressive muscle weakness (HP:0003323)3.07521807
19Premature ovarian failure (HP:0008209)3.06250757
20Abnormality of the labia minora (HP:0012880)2.98335620
21Progressive external ophthalmoplegia (HP:0000590)2.97038139
22Prolonged neonatal jaundice (HP:0006579)2.90822653
23Pelvic girdle muscle weakness (HP:0003749)2.88237833
24CNS hypomyelination (HP:0003429)2.87870972
25Gonadotropin excess (HP:0000837)2.86469799
26Spontaneous abortion (HP:0005268)2.83817472
27Tetraplegia (HP:0002445)2.76601176
28Abnormal trabecular bone morphology (HP:0100671)2.74061013
29Chromsome breakage (HP:0040012)2.73501447
30Facial cleft (HP:0002006)2.73150178
31Entropion (HP:0000621)2.72986495
32Facial hemangioma (HP:0000329)2.70397022
33Megaloblastic anemia (HP:0001889)2.64185629
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62980111
35Horseshoe kidney (HP:0000085)2.62741754
36Abnormality of the umbilical cord (HP:0010881)2.53323272
37Multiple enchondromatosis (HP:0005701)2.50375010
38Meckel diverticulum (HP:0002245)2.47508153
39Secondary amenorrhea (HP:0000869)2.46507043
40Ankle contracture (HP:0006466)2.43712957
41Degeneration of anterior horn cells (HP:0002398)2.43262215
42Abnormality of the anterior horn cell (HP:0006802)2.43262215
43Abnormality of the hip-girdle musculature (HP:0001445)2.38657335
44Abnormality of the musculature of the pelvis (HP:0001469)2.38657335
45External ophthalmoplegia (HP:0000544)2.37344630
46Abnormality of the lower motor neuron (HP:0002366)2.36621966
47Atrophy/Degeneration involving motor neurons (HP:0007373)2.35433832
48Cleft eyelid (HP:0000625)2.31197114
49Hyperglycinemia (HP:0002154)2.30450564
50Spastic paraparesis (HP:0002313)2.28441709
51Aplasia/hypoplasia of the humerus (HP:0006507)2.25884937
52Capillary hemangiomas (HP:0005306)2.22661884
53Absent thumb (HP:0009777)2.22245382
54Abnormality of the ileum (HP:0001549)2.22100543
55Nausea (HP:0002018)2.17955728
56Congenital, generalized hypertrichosis (HP:0004540)2.17681699
57Oligodactyly (hands) (HP:0001180)2.17578873
58Aplasia/hypoplasia of the uterus (HP:0008684)2.15603848
59Short nail (HP:0001799)2.14769826
60Abnormality of the distal phalanges of the toes (HP:0010182)2.13894136
61Amyotrophic lateral sclerosis (HP:0007354)2.13625553
62Sparse eyelashes (HP:0000653)2.12609726
63Muscle fiber splitting (HP:0003555)2.12107555
64Microvesicular hepatic steatosis (HP:0001414)2.10478564
65Gout (HP:0001997)2.09809376
66Areflexia of lower limbs (HP:0002522)2.08028827
67Aplasia/Hypoplasia of the ulna (HP:0006495)2.06795462
68Increased hepatocellular lipid droplets (HP:0006565)2.05541129
69Testicular atrophy (HP:0000029)2.05077007
70Proximal tubulopathy (HP:0000114)2.04402672
71Rimmed vacuoles (HP:0003805)2.04329667
72Abnormality of homocysteine metabolism (HP:0010919)2.03817961
73Homocystinuria (HP:0002156)2.03817961
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02275756
75Abnormality of the preputium (HP:0100587)1.99342466
76Trismus (HP:0000211)1.98174497
77Difficulty climbing stairs (HP:0003551)1.97694140
78Aplasia/Hypoplasia of the earlobes (HP:0009906)1.97647114
79Fused cervical vertebrae (HP:0002949)1.96466782
80Abnormality of chromosome stability (HP:0003220)1.95382128
81Premature graying of hair (HP:0002216)1.94867876
82Bone marrow hypocellularity (HP:0005528)1.94381524
83Abnormalities of placenta or umbilical cord (HP:0001194)1.91890930
84CNS demyelination (HP:0007305)1.91721557
85Oligodactyly (HP:0012165)1.91329803
86Microretrognathia (HP:0000308)1.90556495
87Abnormality of serum amino acid levels (HP:0003112)1.89932713
88Oral leukoplakia (HP:0002745)1.89866071
89Shawl scrotum (HP:0000049)1.88980146
90Hypoplasia of the radius (HP:0002984)1.88594393
91Glucose intolerance (HP:0000833)1.88331218
92Atrioventricular block (HP:0001678)1.88070635
93Stillbirth (HP:0003826)1.87790739
94Hyperglycinuria (HP:0003108)1.87320710
95Lipid accumulation in hepatocytes (HP:0006561)1.87079164
96Stenosis of the external auditory canal (HP:0000402)1.86587026
97Premature rupture of membranes (HP:0001788)1.83982260
98Bundle branch block (HP:0011710)1.81939628
99Abnormal delivery (HP:0001787)1.81865333
100Death in infancy (HP:0001522)1.79434299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.59615886
2BUB15.70523424
3WEE14.27153102
4EPHA24.19252565
5PINK13.35372899
6PLK43.10814560
7CDC73.09470236
8AKT32.58779885
9EIF2AK12.54012394
10BRSK22.52077035
11SRPK12.38993555
12NEK12.26333395
13NEK22.22552508
14STK162.06235413
15PLK12.02071375
16TTK2.01296883
17BRSK11.97901118
18IRAK31.97839770
19EIF2AK31.93619332
20DYRK31.40056632
21TSSK61.33665692
22PLK31.32978951
23PDK31.32727263
24PDK41.32727263
25NME11.21334486
26ZAK1.16312980
27CDK121.16265850
28AURKB1.15797527
29AURKA1.11871083
30STK38L1.08374076
31RPS6KB21.06044277
32CHEK11.02413021
33MKNK21.00392932
34CHEK20.99590933
35CCNB10.92808643
36PNCK0.90758562
37PDK20.87062296
38ATR0.77908054
39CDK40.77391892
40MKNK10.75881512
41STK240.73945484
42PRKCI0.72653433
43IRAK10.70451333
44DYRK20.68365020
45PBK0.68084959
46CDK70.67153443
47NME20.65005731
48CDK20.64796565
49PRKD30.62583430
50ATM0.62402526
51MELK0.62299183
52PAK40.61373195
53MAP3K80.61370041
54MARK10.59411191
55TAOK20.55948172
56IRAK20.55525998
57CSNK2A10.55107300
58CSNK2A20.54920018
59STK30.54224480
60CSNK1G10.53792225
61CDK10.53541596
62BCR0.52380610
63PAK10.50518330
64EIF2AK20.49461515
65STK40.47117868
66ABL20.46780919
67RPS6KA50.46619015
68BRAF0.44651499
69ALK0.42287371
70PLK20.42243470
71MAP3K30.42154154
72VRK10.42114042
73CSNK1E0.40750042
74MST40.39560594
75MARK30.37484745
76CDC42BPA0.33139526
77BRD40.32066588
78PIM10.31669452
79NLK0.27130874
80RPS6KA40.25955525
81TESK20.25389876
82CSNK1G30.23925548
83PRKCG0.23652895
84LATS20.22678197
85CSNK1A10.21476421
86KSR10.20790559
87KDR0.20391557
88PRKDC0.20079979
89IRAK40.19769484
90ARAF0.18948539
91PRPF4B0.18230616
92MAPK100.18217876
93GSK3B0.17779429
94MAPK80.17222610
95CAMK2G0.15954553
96TLK10.15754552
97DYRK1A0.15449050
98CSNK1A1L0.15116943
99CHUK0.14157706
100CAMK2B0.13993984

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.69891310
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.22533155
3RNA polymerase_Homo sapiens_hsa030204.37401195
4DNA replication_Homo sapiens_hsa030303.45930999
5Basal transcription factors_Homo sapiens_hsa030223.27430026
6RNA transport_Homo sapiens_hsa030133.26929864
7Homologous recombination_Homo sapiens_hsa034403.07662661
8Vitamin B6 metabolism_Homo sapiens_hsa007502.88208293
9Spliceosome_Homo sapiens_hsa030402.75259867
10Mismatch repair_Homo sapiens_hsa034302.64091543
11Pyrimidine metabolism_Homo sapiens_hsa002402.58385510
12Cell cycle_Homo sapiens_hsa041102.34225876
13Nucleotide excision repair_Homo sapiens_hsa034202.23854364
14Ribosome_Homo sapiens_hsa030102.03948388
15Base excision repair_Homo sapiens_hsa034102.00211931
16Fanconi anemia pathway_Homo sapiens_hsa034601.82450486
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78243731
18Regulation of autophagy_Homo sapiens_hsa041401.77331158
19Purine metabolism_Homo sapiens_hsa002301.68277304
20Caffeine metabolism_Homo sapiens_hsa002321.64631206
21Folate biosynthesis_Homo sapiens_hsa007901.61489043
22mRNA surveillance pathway_Homo sapiens_hsa030151.50050079
23RNA degradation_Homo sapiens_hsa030181.46483900
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44459373
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44123801
26Non-homologous end-joining_Homo sapiens_hsa034501.40262056
27Epstein-Barr virus infection_Homo sapiens_hsa051691.39409054
28Oocyte meiosis_Homo sapiens_hsa041141.35906638
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35002182
30p53 signaling pathway_Homo sapiens_hsa041151.32925155
31One carbon pool by folate_Homo sapiens_hsa006701.32244268
32Pentose phosphate pathway_Homo sapiens_hsa000301.32191217
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29577377
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.16346803
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12539289
36Huntingtons disease_Homo sapiens_hsa050161.00760319
37Vitamin digestion and absorption_Homo sapiens_hsa049770.99067619
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.98563383
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93884769
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91116468
41Selenocompound metabolism_Homo sapiens_hsa004500.90163840
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87473140
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.84295942
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80419184
45Parkinsons disease_Homo sapiens_hsa050120.80126498
46Fructose and mannose metabolism_Homo sapiens_hsa000510.79378672
47Linoleic acid metabolism_Homo sapiens_hsa005910.69208900
48Biosynthesis of amino acids_Homo sapiens_hsa012300.61508141
49Glycerolipid metabolism_Homo sapiens_hsa005610.59085329
50Oxidative phosphorylation_Homo sapiens_hsa001900.56926413
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.55981183
52Glutathione metabolism_Homo sapiens_hsa004800.55699718
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53113393
54Metabolic pathways_Homo sapiens_hsa011000.51561702
55Herpes simplex infection_Homo sapiens_hsa051680.51309298
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49698196
57Carbon metabolism_Homo sapiens_hsa012000.47622146
58Fat digestion and absorption_Homo sapiens_hsa049750.44412000
59Renin-angiotensin system_Homo sapiens_hsa046140.44038824
60Arachidonic acid metabolism_Homo sapiens_hsa005900.40489542
61Sphingolipid metabolism_Homo sapiens_hsa006000.36787301
62Circadian rhythm_Homo sapiens_hsa047100.33943157
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33299117
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30434092
65Ether lipid metabolism_Homo sapiens_hsa005650.28210815
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27854176
67Tight junction_Homo sapiens_hsa045300.26008102
68HTLV-I infection_Homo sapiens_hsa051660.25850140
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25824141
70Mineral absorption_Homo sapiens_hsa049780.25783808
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22746553
72Viral carcinogenesis_Homo sapiens_hsa052030.22579432
73Collecting duct acid secretion_Homo sapiens_hsa049660.20650316
74FoxO signaling pathway_Homo sapiens_hsa040680.20616893
75Lysosome_Homo sapiens_hsa041420.17137105
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16738029
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16454228
78Arginine and proline metabolism_Homo sapiens_hsa003300.16188702
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15860321
80Protein export_Homo sapiens_hsa030600.15242083
81Hippo signaling pathway_Homo sapiens_hsa043900.14360429
82Sulfur relay system_Homo sapiens_hsa041220.12385270
83Galactose metabolism_Homo sapiens_hsa000520.11272833
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11192863
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10916001
86Thyroid cancer_Homo sapiens_hsa052160.09213368
87beta-Alanine metabolism_Homo sapiens_hsa004100.07085932
88Antigen processing and presentation_Homo sapiens_hsa046120.04992823
89Retinol metabolism_Homo sapiens_hsa008300.03455642
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.01857130
91Alzheimers disease_Homo sapiens_hsa050100.01837308
92Steroid biosynthesis_Homo sapiens_hsa001000.00477444
93Cardiac muscle contraction_Homo sapiens_hsa04260-0.0453470
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0304387
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0297496
96Butanoate metabolism_Homo sapiens_hsa00650-0.0256834
97Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0256783
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0222997
99NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0138676
100Fatty acid elongation_Homo sapiens_hsa00062-0.0088025

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