MAGEA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.62382695
2synapsis (GO:0007129)5.19800753
3formation of translation preinitiation complex (GO:0001731)5.08020845
4COPI coating of Golgi vesicle (GO:0048205)5.06799711
5Golgi transport vesicle coating (GO:0048200)5.06799711
6chromosome organization involved in meiosis (GO:0070192)4.80904261
7ribosome assembly (GO:0042255)4.72042750
8synaptonemal complex assembly (GO:0007130)4.55214195
9ribosomal small subunit assembly (GO:0000028)4.25458079
10resolution of meiotic recombination intermediates (GO:0000712)4.05841518
11mitotic metaphase plate congression (GO:0007080)3.93416386
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93363474
13nuclear pore complex assembly (GO:0051292)3.89560675
14synaptonemal complex organization (GO:0070193)3.84233718
15ribosomal small subunit biogenesis (GO:0042274)3.77555958
16gonadal mesoderm development (GO:0007506)3.75364926
17DNA synthesis involved in DNA repair (GO:0000731)3.69333914
18regulation of mitotic spindle organization (GO:0060236)3.58499419
19mitotic sister chromatid cohesion (GO:0007064)3.57853488
20mitotic sister chromatid segregation (GO:0000070)3.52450528
21regulation of translational fidelity (GO:0006450)3.50726764
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48775177
23mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.41832132
24metaphase plate congression (GO:0051310)3.40915522
25nuclear pore organization (GO:0006999)3.38979506
26chromosome condensation (GO:0030261)3.37568190
27regulation of early endosome to late endosome transport (GO:2000641)3.37030180
28piRNA metabolic process (GO:0034587)3.36870941
29regulation of RNA export from nucleus (GO:0046831)3.35998612
30male meiosis (GO:0007140)3.34674532
31proline biosynthetic process (GO:0006561)3.31631767
32sister chromatid segregation (GO:0000819)3.31626836
33protein localization to chromosome, centromeric region (GO:0071459)3.30830210
34male meiosis I (GO:0007141)3.30101822
35protein complex localization (GO:0031503)3.28353961
36meiotic nuclear division (GO:0007126)3.25300493
37melanin biosynthetic process (GO:0042438)3.24922703
38protein maturation by protein folding (GO:0022417)3.23942996
39ribosome biogenesis (GO:0042254)3.21822309
40ribonucleoprotein complex biogenesis (GO:0022613)3.21788976
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21696343
42cellular protein complex localization (GO:0034629)3.17435900
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17112971
44DNA packaging (GO:0006323)3.06259437
45rRNA modification (GO:0000154)3.03694278
46rRNA methylation (GO:0031167)3.02992802
47meiosis I (GO:0007127)3.01723514
48regulation of spindle organization (GO:0090224)2.99292785
49fusion of sperm to egg plasma membrane (GO:0007342)2.97575759
50ventricular cardiac muscle cell development (GO:0055015)2.97150163
51ribosomal large subunit biogenesis (GO:0042273)2.96626634
52CENP-A containing nucleosome assembly (GO:0034080)2.94458413
53meiotic cell cycle process (GO:1903046)2.91503340
54establishment of chromosome localization (GO:0051303)2.90294570
55de novo protein folding (GO:0006458)2.88952623
56regulation of nucleobase-containing compound transport (GO:0032239)2.88311144
57mitotic cytokinesis (GO:0000281)2.85825547
58nucleobase-containing small molecule interconversion (GO:0015949)2.85792351
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84288128
60de novo posttranslational protein folding (GO:0051084)2.83643691
61pore complex assembly (GO:0046931)2.83365693
62sister chromatid cohesion (GO:0007062)2.81546114
63establishment of integrated proviral latency (GO:0075713)2.81005118
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.80858586
65regulation of gonadotropin secretion (GO:0032276)2.80076345
66mitochondrial fusion (GO:0008053)2.79942596
67melanin metabolic process (GO:0006582)2.79465784
68histone exchange (GO:0043486)2.77422348
69protein localization to kinetochore (GO:0034501)2.76625610
70DNA unwinding involved in DNA replication (GO:0006268)2.74232519
71meiotic chromosome segregation (GO:0045132)2.74100168
72binding of sperm to zona pellucida (GO:0007339)2.72603889
73chaperone-mediated protein complex assembly (GO:0051131)2.71102429
74mitotic spindle checkpoint (GO:0071174)2.69815532
75regulation of chromosome segregation (GO:0051983)2.69203841
76positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.66530506
77peptidyl-proline hydroxylation (GO:0019511)2.64053049
78mitotic nuclear envelope disassembly (GO:0007077)2.60507440
79spindle assembly involved in mitosis (GO:0090307)2.60131691
80mitochondrial DNA metabolic process (GO:0032042)2.58846108
81DNA replication checkpoint (GO:0000076)2.58741361
82microtubule depolymerization (GO:0007019)2.58436657
83regulation of translational initiation (GO:0006446)2.58175643
84translational initiation (GO:0006413)2.55372752
85anterior/posterior axis specification, embryo (GO:0008595)2.53957735
86protein retention in ER lumen (GO:0006621)2.53957375
87trophoblast giant cell differentiation (GO:0060707)2.52881067
88chromatin remodeling at centromere (GO:0031055)2.52849711
89mitotic spindle assembly checkpoint (GO:0007094)2.52153469
90spindle checkpoint (GO:0031577)2.49876851
91chromosome segregation (GO:0007059)2.48429449
92positive regulation of translational initiation (GO:0045948)2.47288541
93nucleotide transmembrane transport (GO:1901679)2.46333180
94negative regulation of DNA repair (GO:0045738)2.46263905
95spindle assembly checkpoint (GO:0071173)2.45891858
96membrane disassembly (GO:0030397)2.45587311
97nuclear envelope disassembly (GO:0051081)2.45587311
98proteasome assembly (GO:0043248)2.44728361
99mitochondrial fission (GO:0000266)2.41346511
100basement membrane organization (GO:0071711)2.38629731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.73027824
2E2F7_22180533_ChIP-Seq_HELA_Human4.18812935
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.72210789
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.61734977
5ZNF263_19887448_ChIP-Seq_K562_Human3.22887600
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19762332
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03329661
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00458214
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.90977238
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58060390
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56301261
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55899225
13DCP1A_22483619_ChIP-Seq_HELA_Human2.41322620
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35863279
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33090638
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27202355
17AR_21909140_ChIP-Seq_LNCAP_Human2.21417612
18ZFX_18555785_ChIP-Seq_MESCs_Mouse2.20049505
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19389047
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.18453746
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.16748017
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13458442
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07648441
24* XRN2_22483619_ChIP-Seq_HELA_Human2.07138141
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05965246
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00164543
27* TTF2_22483619_ChIP-Seq_HELA_Human1.92856057
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.85576944
29GABP_19822575_ChIP-Seq_HepG2_Human1.79490684
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69713071
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68790877
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68132850
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67591569
34TFEB_21752829_ChIP-Seq_HELA_Human1.66099248
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63411054
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63228064
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.60637831
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59360135
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58740229
40HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.58632003
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54430327
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53961104
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53126370
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50031039
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47183539
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47168319
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.44750399
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42687514
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42236446
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42154572
51CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.41456292
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38121389
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37493378
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36974533
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36393691
56KDM5A_27292631_Chip-Seq_BREAST_Human1.36034641
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35529793
58ELK1_19687146_ChIP-ChIP_HELA_Human1.34631404
59ATF3_27146783_Chip-Seq_COLON_Human1.33589499
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33362687
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32651519
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32305127
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.30994290
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28293597
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26158792
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24756664
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22246595
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.22245691
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.21079855
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18295159
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17056151
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16443259
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15948728
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15323464
75RACK7_27058665_Chip-Seq_MCF-7_Human1.14432085
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14371392
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.14360621
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12461668
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09401248
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.08854303
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07581606
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06928687
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06875285
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06451532
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03811535
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03195826
87TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03031807
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00880681
89TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99380992
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99010597
91TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98294852
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98070824
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98070824
94VDR_23849224_ChIP-Seq_CD4+_Human0.97536560
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97429667
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97238527
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97201687
98CHD1_26751641_Chip-Seq_LNCaP_Human0.95938963
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95657187
100FOXP3_21729870_ChIP-Seq_TREG_Human0.94276951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.17480024
2MP0002877_abnormal_melanocyte_morpholog3.50679111
3MP0010030_abnormal_orbit_morphology3.04746768
4MP0004957_abnormal_blastocyst_morpholog2.97160864
5MP0005408_hypopigmentation2.85162506
6MP0005451_abnormal_body_composition2.80018282
7MP0003693_abnormal_embryo_hatching2.79806581
8MP0009697_abnormal_copulation2.76772789
9MP0003111_abnormal_nucleus_morphology2.65906227
10MP0008932_abnormal_embryonic_tissue2.50448145
11MP0003077_abnormal_cell_cycle2.45951158
12MP0005257_abnormal_intraocular_pressure2.30370121
13MP0008058_abnormal_DNA_repair2.18765618
14MP0008007_abnormal_cellular_replicative2.18532282
15MP0001661_extended_life_span2.12238740
16MP0010094_abnormal_chromosome_stability2.11938636
17MP0004233_abnormal_muscle_weight2.05767630
18MP0000358_abnormal_cell_content/1.96273046
19MP0010234_abnormal_vibrissa_follicle1.93165638
20MP0008438_abnormal_cutaneous_collagen1.85341887
21MP0002210_abnormal_sex_determination1.74408531
22MP0005058_abnormal_lysosome_morphology1.70061087
23MP0003136_yellow_coat_color1.68449270
24MP0003890_abnormal_embryonic-extraembry1.65093414
25MP0001730_embryonic_growth_arrest1.64032308
26MP0006035_abnormal_mitochondrial_morpho1.63824370
27MP0002796_impaired_skin_barrier1.62728632
28MP0004858_abnormal_nervous_system1.60777685
29MP0005501_abnormal_skin_physiology1.59674221
30MP0000350_abnormal_cell_proliferation1.56179923
31MP0003941_abnormal_skin_development1.49557036
32MP0001929_abnormal_gametogenesis1.45700775
33MP0003186_abnormal_redox_activity1.45499507
34MP0009053_abnormal_anal_canal1.43505621
35MP0004272_abnormal_basement_membrane1.40977322
36MP0001348_abnormal_lacrimal_gland1.39396400
37MP0002080_prenatal_lethality1.38801798
38MP0003566_abnormal_cell_adhesion1.38285953
39MP0005380_embryogenesis_phenotype1.37468190
40MP0001672_abnormal_embryogenesis/_devel1.37468190
41MP0005623_abnormal_meninges_morphology1.31155107
42MP0002084_abnormal_developmental_patter1.29860429
43MP0002938_white_spotting1.27925077
44MP0001145_abnormal_male_reproductive1.27070653
45MP0001697_abnormal_embryo_size1.25285394
46MP0002060_abnormal_skin_morphology1.25139649
47MP0010368_abnormal_lymphatic_system1.25053802
48MP0002075_abnormal_coat/hair_pigmentati1.24353606
49MP0000537_abnormal_urethra_morphology1.22366870
50MP0010352_gastrointestinal_tract_polyps1.21987879
51MP0002086_abnormal_extraembryonic_tissu1.21773203
52MP0010307_abnormal_tumor_latency1.21723909
53MP0004381_abnormal_hair_follicle1.17283883
54MP0002085_abnormal_embryonic_tissue1.16637155
55MP0003868_abnormal_feces_composition1.15048052
56MP0000490_abnormal_crypts_of1.13585788
57MP0003984_embryonic_growth_retardation1.12228685
58MP0005174_abnormal_tail_pigmentation1.11456117
59MP0000653_abnormal_sex_gland1.09631560
60MP0003385_abnormal_body_wall1.08415505
61MP0002088_abnormal_embryonic_growth/wei1.07776127
62MP0002163_abnormal_gland_morphology1.06686536
63MP0001186_pigmentation_phenotype1.04182457
64MP0003698_abnormal_male_reproductive1.02915182
65MP0002095_abnormal_skin_pigmentation1.02033478
66MP0000647_abnormal_sebaceous_gland0.99436805
67MP0002269_muscular_atrophy0.98539626
68MP0000762_abnormal_tongue_morphology0.97261429
69MP0003937_abnormal_limbs/digits/tail_de0.97061833
70MP0003705_abnormal_hypodermis_morpholog0.96281809
71MP0001849_ear_inflammation0.95930190
72MP0005384_cellular_phenotype0.95346808
73MP0003959_abnormal_lean_body0.92887692
74MP0003453_abnormal_keratinocyte_physiol0.92803195
75MP0005197_abnormal_uvea_morphology0.92025282
76MP0002089_abnormal_postnatal_growth/wei0.91608062
77MP0000579_abnormal_nail_morphology0.89824695
78MP0003786_premature_aging0.89648895
79MP0005621_abnormal_cell_physiology0.88371180
80MP0000003_abnormal_adipose_tissue0.88251234
81MP0008260_abnormal_autophagy0.87887527
82MP0000627_abnormal_mammary_gland0.86225904
83MP0000733_abnormal_muscle_development0.83971029
84MP0000462_abnormal_digestive_system0.83395208
85MP0009840_abnormal_foam_cell0.82961297
86MP0000015_abnormal_ear_pigmentation0.82552175
87MP0004185_abnormal_adipocyte_glucose0.82425436
88MP0005075_abnormal_melanosome_morpholog0.80674041
89MP0001915_intracranial_hemorrhage0.80514273
90MP0002161_abnormal_fertility/fecundity0.79714478
91MP0005330_cardiomyopathy0.78529841
92MP0003699_abnormal_female_reproductive0.77649290
93MP0002697_abnormal_eye_size0.76415210
94MP0000313_abnormal_cell_death0.76181640
95MP0004197_abnormal_fetal_growth/weight/0.75781446
96MP0003943_abnormal_hepatobiliary_system0.75777622
97MP0005076_abnormal_cell_differentiation0.75449167
98MP0010771_integument_phenotype0.75443166
99MP0003936_abnormal_reproductive_system0.74995636
100MP0004264_abnormal_extraembryonic_tissu0.74744798

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)4.61630938
2Abnormal auditory evoked potentials (HP:0006958)4.16287867
3White forelock (HP:0002211)3.82403755
4Abnormality of the distal phalanges of the toes (HP:0010182)3.65784859
5Patchy hypopigmentation of hair (HP:0011365)3.65357667
6Spastic paraparesis (HP:0002313)3.31600881
7Upper limb muscle weakness (HP:0003484)3.30189492
8Entropion (HP:0000621)3.19500673
9Premature rupture of membranes (HP:0001788)3.18278144
10Hand muscle atrophy (HP:0009130)3.04891245
11Nuclear cataract (HP:0100018)3.02780419
12Short nail (HP:0001799)2.88036617
13Paraparesis (HP:0002385)2.83382712
14Hypopigmentation of the fundus (HP:0007894)2.82073368
15Upper limb amyotrophy (HP:0009129)2.81036825
16Distal upper limb amyotrophy (HP:0007149)2.81036825
17Abnormality of the fetal cardiovascular system (HP:0010948)2.77400580
18Abnormal umbilical cord blood vessels (HP:0011403)2.77400580
19Single umbilical artery (HP:0001195)2.77400580
20Achilles tendon contracture (HP:0001771)2.76078608
21Cutaneous melanoma (HP:0012056)2.75965929
22Abnormality of the umbilical cord (HP:0010881)2.66630011
23Hypoplasia of the capital femoral epiphysis (HP:0003090)2.61042976
24Progressive external ophthalmoplegia (HP:0000590)2.54590277
25Spinal cord lesions (HP:0100561)2.51551189
26Syringomyelia (HP:0003396)2.51551189
27Cerebral hypomyelination (HP:0006808)2.46230040
28Abnormality of the Achilles tendon (HP:0005109)2.44154822
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37945468
30Deviation of the thumb (HP:0009603)2.35009177
31Proximal placement of thumb (HP:0009623)2.34800099
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.34591162
33Osteolytic defects of the hand bones (HP:0009699)2.34591162
34Ependymoma (HP:0002888)2.31452196
35Back pain (HP:0003418)2.30597048
36Down-sloping shoulders (HP:0200021)2.25408602
37Poikiloderma (HP:0001029)2.24576538
38Elbow flexion contracture (HP:0002987)2.23854589
39Absent epiphyses (HP:0010577)2.23092186
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23092186
41Flattened epiphyses (HP:0003071)2.22610188
42Deep palmar crease (HP:0006191)2.21153170
43Protrusio acetabuli (HP:0003179)2.16165485
44Increased connective tissue (HP:0009025)2.15847587
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15834474
46Reduced antithrombin III activity (HP:0001976)2.14495326
47Small epiphyses (HP:0010585)2.13452085
48Distal lower limb muscle weakness (HP:0009053)2.13176255
49Difficulty climbing stairs (HP:0003551)2.12481786
50Neoplasm of the peripheral nervous system (HP:0100007)2.11138880
51Ulnar bowing (HP:0003031)2.09229503
52Trismus (HP:0000211)2.06297102
53Oligodactyly (hands) (HP:0001180)2.06204727
54Ankyloglossia (HP:0010296)2.05119620
55Increased nuchal translucency (HP:0010880)2.04027919
56Abnormality of the lower motor neuron (HP:0002366)2.02519233
57Microvesicular hepatic steatosis (HP:0001414)2.02505386
58Oligodactyly (HP:0012165)2.01829835
59Heterochromia iridis (HP:0001100)2.01360918
60Flat acetabular roof (HP:0003180)2.00490763
61Shoulder girdle muscle weakness (HP:0003547)1.99114373
62Delayed cranial suture closure (HP:0000270)1.99097116
63Delayed epiphyseal ossification (HP:0002663)1.97869396
64Double outlet right ventricle (HP:0001719)1.96468943
65Congenital malformation of the right heart (HP:0011723)1.96468943
66Thin bony cortex (HP:0002753)1.95639274
67Wormian bones (HP:0002645)1.95611467
68Abnormality of oral frenula (HP:0000190)1.91315907
69Abnormal trabecular bone morphology (HP:0100671)1.89221661
70Leiomyosarcoma (HP:0100243)1.88702034
71Uterine leiomyosarcoma (HP:0002891)1.88702034
72Distal lower limb amyotrophy (HP:0008944)1.88616593
73Septate vagina (HP:0001153)1.88340294
74Alacrima (HP:0000522)1.87702835
75Fatigue (HP:0012378)1.86811806
76Broad distal phalanx of finger (HP:0009836)1.85447776
77Selective tooth agenesis (HP:0001592)1.81050794
78Elevated alkaline phosphatase (HP:0003155)1.79213768
79Limb-girdle muscle atrophy (HP:0003797)1.77838273
80Distal sensory impairment (HP:0002936)1.77257226
81Chromsome breakage (HP:0040012)1.76654030
82Abnormalities of placenta or umbilical cord (HP:0001194)1.75932757
83Hypolipoproteinemia (HP:0010981)1.75509485
84Tetraparesis (HP:0002273)1.74548398
85Hypoalphalipoproteinemia (HP:0003233)1.73403304
86Premature skin wrinkling (HP:0100678)1.72541625
87Hypobetalipoproteinemia (HP:0003563)1.72338706
88Male infertility (HP:0003251)1.72218504
89Blue irides (HP:0000635)1.71484921
90Ureteral duplication (HP:0000073)1.71163268
91Anal stenosis (HP:0002025)1.71094450
92Astrocytoma (HP:0009592)1.69960320
93Abnormality of the astrocytes (HP:0100707)1.69960320
94Dislocated radial head (HP:0003083)1.69222765
95Multiple lipomas (HP:0001012)1.66407719
96Vertebral arch anomaly (HP:0008438)1.66398186
97Abnormal autonomic nervous system physiology (HP:0012332)1.66016415
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65214197
99Horseshoe kidney (HP:0000085)1.64837458
100Chin dimple (HP:0010751)1.64593700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.94996947
2EPHA23.36151114
3NME23.20821601
4SCYL22.92080675
5PBK2.89201109
6NEK12.88157289
7BUB12.73568742
8WEE12.50859760
9MST1R2.39229052
10LMTK22.29416257
11MET2.27702133
12ERBB42.27044049
13TTK2.22537208
14PAK42.19491825
15EIF2AK31.89720321
16TSSK61.87343275
17IRAK21.82598776
18PDK21.79788336
19BRAF1.76576360
20CDK121.69916947
21EIF2AK11.64295036
22RPS6KB21.58262008
23MAP3K121.55556364
24CDK191.46957215
25PNCK1.44179076
26BRSK11.43737603
27PDGFRA1.29761449
28NEK21.18878557
29BRSK21.17385355
30PRPF4B1.16738012
31PAK61.14725800
32PTK21.13898170
33FLT31.12813998
34TRIB31.11864577
35KSR21.09907331
36TAOK21.09315177
37STK161.07931976
38CLK11.05996774
39KSR11.05246487
40ILK1.04641583
41PLK11.04387139
42NTRK11.01328021
43ERN10.99217400
44ICK0.96107541
45CHEK20.93769423
46AURKA0.92691485
47TESK20.92155482
48TTN0.91794486
49SIK30.91529940
50IRAK40.89853938
51SMG10.88701409
52MAP3K80.87954041
53ARAF0.86784840
54PAK20.83247183
55CDK80.83036486
56CDK70.82739744
57MAP3K20.81401345
58AURKB0.80925109
59DYRK30.79648587
60PRKD30.79260490
61ABL20.79104465
62PDGFRB0.73572557
63CDK60.72824646
64ZAK0.72634634
65PLK40.71914871
66CCNB10.66474418
67AKT20.65947097
68MOS0.65643735
69TESK10.64849805
70IRAK10.64391201
71MTOR0.64135641
72CHEK10.62179404
73CDK40.62103927
74SRPK10.60301448
75CDK11A0.58153534
76LATS20.57475045
77NEK90.57373126
78ERBB30.57158917
79RAF10.55207611
80LRRK20.55206559
81PIM20.53029135
82MAP3K90.52565875
83ZAP700.51356370
84PRKCI0.50428239
85PAK10.49925457
86MAPKAPK30.48555198
87CDK180.48200200
88CDK150.47678296
89PHKG20.46973274
90PHKG10.46973274
91MELK0.45466429
92BMPR20.45345211
93CDC70.43260587
94ATR0.42520597
95STK100.41998247
96SIK10.40372079
97TRIM280.39134168
98PLK30.38340136
99NEK60.37684652
100TGFBR10.37301608

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.76151745
2DNA replication_Homo sapiens_hsa030302.94795415
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78861775
4Mismatch repair_Homo sapiens_hsa034302.64967951
5Nucleotide excision repair_Homo sapiens_hsa034202.45152301
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42870648
7Cell cycle_Homo sapiens_hsa041102.28141805
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22776689
9Ribosome_Homo sapiens_hsa030102.21713066
10N-Glycan biosynthesis_Homo sapiens_hsa005102.19426104
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14373113
12RNA transport_Homo sapiens_hsa030132.08332128
13Proteasome_Homo sapiens_hsa030502.05447211
14p53 signaling pathway_Homo sapiens_hsa041152.03107584
15Pyrimidine metabolism_Homo sapiens_hsa002401.91242273
16Base excision repair_Homo sapiens_hsa034101.85340596
17RNA polymerase_Homo sapiens_hsa030201.80392400
18Non-homologous end-joining_Homo sapiens_hsa034501.79870432
19Spliceosome_Homo sapiens_hsa030401.60144618
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53664524
21Prion diseases_Homo sapiens_hsa050201.52875678
22Folate biosynthesis_Homo sapiens_hsa007901.52699398
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51974937
24Biosynthesis of amino acids_Homo sapiens_hsa012301.51942196
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.37004842
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.35150733
27Homologous recombination_Homo sapiens_hsa034401.29553117
28Phenylalanine metabolism_Homo sapiens_hsa003601.27857447
29Fanconi anemia pathway_Homo sapiens_hsa034601.21180708
30Tyrosine metabolism_Homo sapiens_hsa003501.19178015
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.17260336
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16605224
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12979767
34Carbon metabolism_Homo sapiens_hsa012001.12876245
35Pyruvate metabolism_Homo sapiens_hsa006201.12779565
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08521576
37Small cell lung cancer_Homo sapiens_hsa052221.07620439
38mRNA surveillance pathway_Homo sapiens_hsa030151.05817821
39Galactose metabolism_Homo sapiens_hsa000521.01736983
40Pentose phosphate pathway_Homo sapiens_hsa000301.00861131
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98137517
42One carbon pool by folate_Homo sapiens_hsa006700.95626278
43Purine metabolism_Homo sapiens_hsa002300.94757146
44Selenocompound metabolism_Homo sapiens_hsa004500.94658975
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93459688
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92290383
47Basal transcription factors_Homo sapiens_hsa030220.91081229
48Fatty acid elongation_Homo sapiens_hsa000620.89143855
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85656526
50Lysine degradation_Homo sapiens_hsa003100.81701819
51Vitamin B6 metabolism_Homo sapiens_hsa007500.81579105
52Viral carcinogenesis_Homo sapiens_hsa052030.79118381
53Thyroid cancer_Homo sapiens_hsa052160.78439800
54Chronic myeloid leukemia_Homo sapiens_hsa052200.75811977
55Sulfur metabolism_Homo sapiens_hsa009200.75333483
56ErbB signaling pathway_Homo sapiens_hsa040120.70749640
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69797270
58Pancreatic cancer_Homo sapiens_hsa052120.68707629
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68002465
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66201333
61TGF-beta signaling pathway_Homo sapiens_hsa043500.66001029
62Hippo signaling pathway_Homo sapiens_hsa043900.65114557
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64068123
64Alcoholism_Homo sapiens_hsa050340.62788426
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60283580
66mTOR signaling pathway_Homo sapiens_hsa041500.60001961
67MicroRNAs in cancer_Homo sapiens_hsa052060.58910694
68Glutathione metabolism_Homo sapiens_hsa004800.57843325
69Proteoglycans in cancer_Homo sapiens_hsa052050.57640789
70Oocyte meiosis_Homo sapiens_hsa041140.57625596
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57566032
72Arginine and proline metabolism_Homo sapiens_hsa003300.57318019
73ECM-receptor interaction_Homo sapiens_hsa045120.56143351
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55344743
75Circadian rhythm_Homo sapiens_hsa047100.55238947
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54239631
77Adherens junction_Homo sapiens_hsa045200.53750802
78Bladder cancer_Homo sapiens_hsa052190.53734991
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.52519252
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.51455860
81Insulin signaling pathway_Homo sapiens_hsa049100.49994576
82Arginine biosynthesis_Homo sapiens_hsa002200.49775238
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48752794
84Non-small cell lung cancer_Homo sapiens_hsa052230.48394079
85Systemic lupus erythematosus_Homo sapiens_hsa053220.48197297
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46420297
87Prostate cancer_Homo sapiens_hsa052150.45011257
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44699591
89Shigellosis_Homo sapiens_hsa051310.43971122
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42523303
91Epstein-Barr virus infection_Homo sapiens_hsa051690.42521880
92Apoptosis_Homo sapiens_hsa042100.41754188
93Fructose and mannose metabolism_Homo sapiens_hsa000510.41097995
94beta-Alanine metabolism_Homo sapiens_hsa004100.39049031
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38627407
96Endocytosis_Homo sapiens_hsa041440.37865583
97Renal cell carcinoma_Homo sapiens_hsa052110.37548411
98Starch and sucrose metabolism_Homo sapiens_hsa005000.36391756
99Glioma_Homo sapiens_hsa052140.36304998
100HTLV-I infection_Homo sapiens_hsa051660.34778676

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