MAFK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.94402979
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.94402979
3antigen processing and presentation of endogenous antigen (GO:0019883)4.59412175
4mannose metabolic process (GO:0006013)3.93556393
5positive regulation of p38MAPK cascade (GO:1900745)3.92832372
6regulation of interleukin-12 biosynthetic process (GO:0045075)3.90284637
7positive regulation of gamma-delta T cell activation (GO:0046645)3.60972298
8regulation of gamma-delta T cell differentiation (GO:0045586)3.36092362
9positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.33468458
10adherens junction assembly (GO:0034333)3.22759914
11cell-substrate adherens junction assembly (GO:0007045)3.21381616
12focal adhesion assembly (GO:0048041)3.21381616
13JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.20425312
14positive regulation of natural killer cell differentiation (GO:0032825)3.18846321
15regulation of gamma-delta T cell activation (GO:0046643)3.14597133
16regulation of p38MAPK cascade (GO:1900744)3.12270202
17stress fiber assembly (GO:0043149)3.10868640
18positive thymic T cell selection (GO:0045059)3.07989071
19negative regulation of erythrocyte differentiation (GO:0045647)3.05945339
20apoptotic process involved in morphogenesis (GO:0060561)3.03771056
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02740511
22negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.93839802
23regulation of early endosome to late endosome transport (GO:2000641)2.90440329
24embryonic process involved in female pregnancy (GO:0060136)2.89701580
25activation of Rac GTPase activity (GO:0032863)2.89537224
26positive regulation of Cdc42 GTPase activity (GO:0043089)2.87648748
27desmosome organization (GO:0002934)2.84856190
28basement membrane organization (GO:0071711)2.84802157
29semaphorin-plexin signaling pathway (GO:0071526)2.84172617
30cytoskeletal anchoring at plasma membrane (GO:0007016)2.83121570
31Golgi transport vesicle coating (GO:0048200)2.81092256
32COPI coating of Golgi vesicle (GO:0048205)2.81092256
33germinal center formation (GO:0002467)2.80541399
34regulation of T-helper 2 cell differentiation (GO:0045628)2.80492180
35positive regulation of receptor recycling (GO:0001921)2.79434215
36response to type I interferon (GO:0034340)2.74781864
37vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72734546
38positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.72693295
39response to muramyl dipeptide (GO:0032495)2.72531322
40angiogenesis involved in wound healing (GO:0060055)2.72443276
41barbed-end actin filament capping (GO:0051016)2.70210917
42positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69205747
43positive regulation of histone deacetylation (GO:0031065)2.68953757
44low-density lipoprotein particle clearance (GO:0034383)2.68581998
45positive regulation by symbiont of host defense response (GO:0052509)2.67885924
46modulation by symbiont of host defense response (GO:0052031)2.67885924
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67885924
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67885924
49positive regulation by organism of defense response of other organism involved in symbiotic interact2.67885924
50modulation by symbiont of host immune response (GO:0052553)2.67885924
51regulation of interferon-beta biosynthetic process (GO:0045357)2.67876193
52positive regulation of interferon-alpha production (GO:0032727)2.67003087
53response to peptidoglycan (GO:0032494)2.66944880
54response to laminar fluid shear stress (GO:0034616)2.66078284
55regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63700401
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.62930013
57cellular response to type I interferon (GO:0071357)2.61956683
58type I interferon signaling pathway (GO:0060337)2.61956683
59negative regulation of cell size (GO:0045792)2.61427643
60regulation of glucose import in response to insulin stimulus (GO:2001273)2.61128324
61NIK/NF-kappaB signaling (GO:0038061)2.58588861
62endothelial cell chemotaxis (GO:0035767)2.57517183
63activation of MAPKKK activity (GO:0000185)2.55623670
64positive regulation of extracellular matrix organization (GO:1903055)2.54944873
65antigen processing and presentation via MHC class Ib (GO:0002475)2.54541264
66vascular endothelial growth factor signaling pathway (GO:0038084)2.53830643
67regulation of interferon-alpha production (GO:0032647)2.53628639
68skin morphogenesis (GO:0043589)2.52734602
69regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51403975
70atrioventricular valve morphogenesis (GO:0003181)2.51046611
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.49789289
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48620244
73immunoglobulin mediated immune response (GO:0016064)2.47461550
74wound healing, spreading of epidermal cells (GO:0035313)2.46467456
75hepatocyte apoptotic process (GO:0097284)2.44541934
76endothelial tube morphogenesis (GO:0061154)2.44339955
77morphogenesis of an endothelium (GO:0003159)2.44339955
78negative regulation of stress fiber assembly (GO:0051497)2.42482684
79cell adhesion mediated by integrin (GO:0033627)2.42363854
80natural killer cell differentiation (GO:0001779)2.39808842
81positive regulation of B cell differentiation (GO:0045579)2.39092311
82apoptotic cell clearance (GO:0043277)2.38833870
83regulation of extracellular matrix disassembly (GO:0010715)2.38144147
84cell-cell junction maintenance (GO:0045217)2.37984714
85growth hormone receptor signaling pathway (GO:0060396)2.37355153
86regulation of natural killer cell differentiation (GO:0032823)2.36627132
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.36260560
88germ cell migration (GO:0008354)2.35818454
89modulation by symbiont of host cellular process (GO:0044068)2.34431804
90establishment of endothelial barrier (GO:0061028)2.33833527
91definitive hemopoiesis (GO:0060216)2.33609001
92activation of JUN kinase activity (GO:0007257)2.32513117
93regulation of integrin activation (GO:0033623)2.30913341
94megakaryocyte development (GO:0035855)2.30628721
95regulation of apoptotic process involved in morphogenesis (GO:1902337)2.30061398
96hemidesmosome assembly (GO:0031581)2.29911556
97decidualization (GO:0046697)2.29851811
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29601531
99insulin-like growth factor receptor signaling pathway (GO:0048009)2.29569584
100response to progesterone (GO:0032570)2.29516577
101interferon-gamma-mediated signaling pathway (GO:0060333)2.28830277
102cellular response to arsenic-containing substance (GO:0071243)2.28612876
103regulation of ARF GTPase activity (GO:0032312)2.28492812
104response to fluid shear stress (GO:0034405)2.27226711
105positive regulation of protein dephosphorylation (GO:0035307)2.26574476
106regulation of response to interferon-gamma (GO:0060330)2.25189043
107regulation of erythrocyte differentiation (GO:0045646)2.24362729
108endocytic recycling (GO:0032456)2.23308929
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23065008
110negative regulation of fatty acid transport (GO:2000192)2.22764941
111positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.22523239
112regulation of cholesterol storage (GO:0010885)2.21712084
113negative regulation of necroptotic process (GO:0060546)2.21208185
114negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.20995629
115regulation of vitamin D biosynthetic process (GO:0060556)2.20264163
116negative regulation of viral release from host cell (GO:1902187)2.20205664
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.19844002
118fibroblast migration (GO:0010761)2.19719886
119regulation of anoikis (GO:2000209)2.19336205
120protein localization to endosome (GO:0036010)2.19026621
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.18579394
122protoporphyrinogen IX metabolic process (GO:0046501)2.17274537
123positive regulation of endothelial cell apoptotic process (GO:2000353)2.16649613
124activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.16366652
125regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.16237435
126positive regulation of interferon-beta production (GO:0032728)2.15891658
127cell volume homeostasis (GO:0006884)2.15882359
128negative regulation of granulocyte differentiation (GO:0030853)2.15869763
129mRNA transcription (GO:0009299)2.15574819
130embryo implantation (GO:0007566)2.14765926
131positive regulation of odontogenesis (GO:0042482)2.14727010
132cellular response to interferon-alpha (GO:0035457)2.14721776
133embryonic hemopoiesis (GO:0035162)2.14682891
134surfactant homeostasis (GO:0043129)2.14554106
135response to interferon-alpha (GO:0035455)2.14543933
136cellular response to thyroid hormone stimulus (GO:0097067)2.14424308
137myeloid dendritic cell differentiation (GO:0043011)2.14300670
138regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.14289433
139regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13976959
1403-UTR-mediated mRNA stabilization (GO:0070935)2.13701512
141regulation of necrotic cell death (GO:0010939)2.13613682
142regulation of cholesterol homeostasis (GO:2000188)2.13289027
143macrophage activation involved in immune response (GO:0002281)2.13207916
144leukocyte cell-cell adhesion (GO:0007159)2.13202445
145thymic T cell selection (GO:0045061)2.13091110
146regulation of transforming growth factor beta1 production (GO:0032908)2.13065604
147regulation of extracellular matrix organization (GO:1903053)2.13012574
148T cell apoptotic process (GO:0070231)2.11606951
149negative regulation of myotube differentiation (GO:0010832)2.11140958
150pinocytosis (GO:0006907)2.09874580
151hypotonic response (GO:0006971)2.09191397
152glomerular visceral epithelial cell development (GO:0072015)2.08923677
153wound healing, spreading of cells (GO:0044319)2.08583383
154epithelial cell-cell adhesion (GO:0090136)2.08387023
155skeletal muscle adaptation (GO:0043501)2.08135169
156branching involved in mammary gland duct morphogenesis (GO:0060444)2.07756266
157protein retention in ER lumen (GO:0006621)2.07571795
158actin filament bundle organization (GO:0061572)2.07529552
159actin filament bundle assembly (GO:0051017)2.07529552
160receptor catabolic process (GO:0032801)2.06372103
161positive regulation of macrophage differentiation (GO:0045651)2.06224749
162positive regulation of lipid storage (GO:0010884)2.05554217
163negative regulation of interleukin-12 production (GO:0032695)2.05273804
164cell-substrate junction assembly (GO:0007044)2.05104862
165negative regulation of interleukin-8 production (GO:0032717)2.04887315
166platelet aggregation (GO:0070527)2.04142168
167tolerance induction (GO:0002507)2.03939617
168regulation of necroptotic process (GO:0060544)2.03926628
169response to arsenic-containing substance (GO:0046685)2.03681618
170mesodermal cell differentiation (GO:0048333)2.03543263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.75402731
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.73235949
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51104198
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.26077424
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06218800
6GATA1_22025678_ChIP-Seq_K562_Human2.76182458
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65781885
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.44788382
9MYC_22102868_ChIP-Seq_BL_Human2.34193593
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28762789
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23434287
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20917754
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18470663
14CLOCK_20551151_ChIP-Seq_293T_Human2.17572600
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17405088
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14773551
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10696891
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09514538
19* ELK3_25401928_ChIP-Seq_HUVEC_Human2.03659407
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02102781
21VDR_21846776_ChIP-Seq_THP-1_Human2.01438727
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01206649
23* SCL_19346495_ChIP-Seq_HPC-7_Human2.00223687
24* MAF_26560356_Chip-Seq_TH1_Human1.96033203
25* TCF7_22412390_ChIP-Seq_EML_Mouse1.94874526
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.94528231
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89346996
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87487434
29KDM2B_26808549_Chip-Seq_K562_Human1.86379753
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86361879
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83790909
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81643265
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81603696
34* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76560029
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.74981210
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.72601046
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.72600997
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71269139
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68276984
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67752586
41* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66506115
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66008513
43* GATA1_19941826_ChIP-Seq_K562_Human1.65501167
44UTX_26944678_Chip-Seq_JUKART_Human1.65467800
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63856917
46RUNX_20019798_ChIP-Seq_JUKART_Human1.62957701
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61479327
48VDR_24763502_ChIP-Seq_THP-1_Human1.60946581
49KDM2B_26808549_Chip-Seq_DND41_Human1.60334914
50MYB_26560356_Chip-Seq_TH2_Human1.60054474
51* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59857785
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.59700983
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58439133
54* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52328469
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51242441
56ZNF263_19887448_ChIP-Seq_K562_Human1.51012625
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.50635208
58* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49819872
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.49359163
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.49287686
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49280451
62MYB_26560356_Chip-Seq_TH1_Human1.48237139
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45055850
64* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45037270
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44615324
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.43524492
67* ATF3_27146783_Chip-Seq_COLON_Human1.43432462
68* P68_20966046_ChIP-Seq_HELA_Human1.43177469
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42146851
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.40843279
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40395522
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.40204278
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40017728
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.38878095
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.38140170
76SMC4_20622854_ChIP-Seq_HELA_Human1.36838212
77* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35308975
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.34799587
79* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34388125
80* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34388125
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.33275248
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32890616
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32698619
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32111187
85* GATA2_19941826_ChIP-Seq_K562_Human1.32073871
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31829635
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31493839
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.31073808
89* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30749824
90* CREB1_26743006_Chip-Seq_LNCaP_Human1.30230595
91* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29915916
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29124887
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.28066078
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27441288
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26775920
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26304745
97* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25993753
98RACK7_27058665_Chip-Seq_MCF-7_Human1.25880729
99NCOR1_26117541_ChIP-Seq_K562_Human1.25749743
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25572926
101* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24896044
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24840914
103* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24587300
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24455195
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21266671
106TP53_22127205_ChIP-Seq_IMR90_Human1.20484865
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20296339
108* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20054381
109* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17564725
110SPI1_23127762_ChIP-Seq_K562_Human1.17354770
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16936269
112GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16891470
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15134358
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14676905
115* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12695357
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12476622
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11555977
118MAF_26560356_Chip-Seq_TH2_Human1.10603542
119LXR_22292898_ChIP-Seq_THP-1_Human1.10228202
120SPI1_23547873_ChIP-Seq_NB4_Human1.10160152
121* BCOR_27268052_Chip-Seq_Bcells_Human1.07672752
122SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07472815
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.06903281
124TBX20_22080862_ChIP-Seq_HEART_Mouse1.06732504
125TBX20_22328084_ChIP-Seq_HEART_Mouse1.06732504
126* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05807829
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.04849366
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04607643
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04187834
130* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03782191
131* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03427577
132* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03424877
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03181596
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02839976
135* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02586136
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01933353
137P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01820918
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00601101
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00068858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology2.98362300
2MP0005451_abnormal_body_composition2.72249357
3MP0003300_gastrointestinal_ulcer2.57255703
4MP0003303_peritoneal_inflammation2.50070654
5MP0003724_increased_susceptibility_to2.30418011
6MP0003436_decreased_susceptibility_to2.30119072
7MP0004510_myositis2.10125439
8MP0003566_abnormal_cell_adhesion2.06835462
9MP0000685_abnormal_immune_system2.03873143
10MP0006054_spinal_hemorrhage2.01781800
11MP0001835_abnormal_antigen_presentation2.01009790
12MP0010352_gastrointestinal_tract_polyps1.98813803
13MP0003172_abnormal_lysosome_physiology1.98413062
14MP0003705_abnormal_hypodermis_morpholog1.97801400
15MP0000751_myopathy1.93724822
16MP0008260_abnormal_autophagy1.93546699
17MP0005409_darkened_coat_color1.91260456
18MP0002166_altered_tumor_susceptibility1.89719327
19MP0004947_skin_inflammation1.89388425
20MP0001849_ear_inflammation1.86616629
21MP0003656_abnormal_erythrocyte_physiolo1.81531764
22MP0009278_abnormal_bone_marrow1.80426825
23MP0008438_abnormal_cutaneous_collagen1.74954830
24MP0000013_abnormal_adipose_tissue1.72822095
25MP0003828_pulmonary_edema1.72279607
26MP0001853_heart_inflammation1.70963870
27MP0001790_abnormal_immune_system1.69136306
28MP0005387_immune_system_phenotype1.69136306
29MP0002877_abnormal_melanocyte_morpholog1.65073293
30MP0005000_abnormal_immune_tolerance1.64696770
31MP0009785_altered_susceptibility_to1.63868993
32MP0001545_abnormal_hematopoietic_system1.62670035
33MP0005397_hematopoietic_system_phenotyp1.62670035
34MP0000003_abnormal_adipose_tissue1.59197839
35MP0005464_abnormal_platelet_physiology1.58510843
36MP0005375_adipose_tissue_phenotype1.58140215
37MP0005275_abnormal_skin_tensile1.56197369
38MP0001800_abnormal_humoral_immune1.54646872
39MP0010155_abnormal_intestine_physiology1.51265077
40MP0005023_abnormal_wound_healing1.50954054
41MP0005666_abnormal_adipose_tissue1.50763771
42MP0005025_abnormal_response_to1.50614322
43MP0002796_impaired_skin_barrier1.49793409
44MP0002452_abnormal_antigen_presenting1.48582132
45MP0001533_abnormal_skeleton_physiology1.48323913
46MP0002405_respiratory_system_inflammati1.46538751
47MP0002419_abnormal_innate_immunity1.43887270
48MP0002723_abnormal_immune_serum1.42140243
49MP0002254_reproductive_system_inflammat1.41914830
50MP0010368_abnormal_lymphatic_system1.41773835
51MP0001348_abnormal_lacrimal_gland1.41541130
52MP0000465_gastrointestinal_hemorrhage1.40964308
53MP0004808_abnormal_hematopoietic_stem1.40924079
54MP0002006_tumorigenesis1.40107167
55MP0003279_aneurysm1.39008503
56MP0009840_abnormal_foam_cell1.35477676
57MP0004858_abnormal_nervous_system1.35229982
58MP0001958_emphysema1.34718016
59MP0000343_altered_response_to1.32502699
60MP0005076_abnormal_cell_differentiation1.31932160
61MP0001873_stomach_inflammation1.31412223
62MP0002148_abnormal_hypersensitivity_rea1.31081564
63MP0002420_abnormal_adaptive_immunity1.30843442
64MP0001819_abnormal_immune_cell1.30669822
65MP0002396_abnormal_hematopoietic_system1.30073053
66MP0003763_abnormal_thymus_physiology1.28947982
67MP0005671_abnormal_response_to1.26826733
68MP0002138_abnormal_hepatobiliary_system1.25541622
69MP0001845_abnormal_inflammatory_respons1.25120552
70MP0002398_abnormal_bone_marrow1.24927601
71MP0004084_abnormal_cardiac_muscle1.24150892
72MP0003453_abnormal_keratinocyte_physiol1.23798520
73MP0002933_joint_inflammation1.23735073
74MP0003191_abnormal_cellular_cholesterol1.23293281
75MP0003075_altered_response_to1.20692798
76MP0001879_abnormal_lymphatic_vessel1.20538911
77MP0000678_abnormal_parathyroid_gland1.19521274
78MP0006138_congestive_heart_failure1.19183942
79MP0003448_altered_tumor_morphology1.17576160
80MP0009333_abnormal_splenocyte_physiolog1.16683449
81MP0002060_abnormal_skin_morphology1.16044611
82MP0005257_abnormal_intraocular_pressure1.15084385
83MP0000767_abnormal_smooth_muscle1.13925414
84MP0000750_abnormal_muscle_regeneration1.13439988
85MP0000858_altered_metastatic_potential1.12371001
86MP0003091_abnormal_cell_migration1.11752314
87MP0004233_abnormal_muscle_weight1.11742668
88MP0005670_abnormal_white_adipose1.11728332
89MP0004147_increased_porphyrin_level1.11145445
90MP0002722_abnormal_immune_system1.09143277
91MP0000716_abnormal_immune_system1.09088023
92MP0000689_abnormal_spleen_morphology1.06905035
93MP0006082_CNS_inflammation1.04684826
94MP0004381_abnormal_hair_follicle1.03651669
95MP0009764_decreased_sensitivity_to1.03181424
96MP0002429_abnormal_blood_cell1.03002179
97MP0005501_abnormal_skin_physiology1.02323154
98MP0003866_abnormal_defecation1.01930307
99MP0008469_abnormal_protein_level1.00620296
100MP0005330_cardiomyopathy0.99792162
101MP0000747_muscle_weakness0.99676595
102MP0002896_abnormal_bone_mineralization0.99220945
103MP0009384_cardiac_valve_regurgitation0.99049209
104MP0000759_abnormal_skeletal_muscle0.99018821
105MP0004185_abnormal_adipocyte_glucose0.97202113
106MP0010234_abnormal_vibrissa_follicle0.97019147
107MP0008775_abnormal_heart_ventricle0.96668058
108MP0000249_abnormal_blood_vessel0.95199557
109MP0002998_abnormal_bone_remodeling0.94741105
110MP0001851_eye_inflammation0.93612253
111MP0003329_amyloid_beta_deposits0.92889704
112MP0005390_skeleton_phenotype0.92756546
113MP0010630_abnormal_cardiac_muscle0.91483879
114MP0005166_decreased_susceptibility_to0.90850286
115MP0000490_abnormal_crypts_of0.89422968
116MP0005165_increased_susceptibility_to0.88867952
117MP0004272_abnormal_basement_membrane0.87842438
118MP0008961_abnormal_basal_metabolism0.86995458
119MP0000609_abnormal_liver_physiology0.86377224
120MP0010307_abnormal_tumor_latency0.86316506
121MP0005083_abnormal_biliary_tract0.84292359
122MP0005164_abnormal_response_to0.83558292
123MP0001243_abnormal_dermal_layer0.83409308
124MP0002136_abnormal_kidney_physiology0.82584904
125MP0000703_abnormal_thymus_morphology0.82583241
126MP0009931_abnormal_skin_appearance0.81689031
127MP0005167_abnormal_blood-brain_barrier0.81262782
128MP0004087_abnormal_muscle_fiber0.80782057
129MP0002332_abnormal_exercise_endurance0.80190674
130MP0002139_abnormal_hepatobiliary_system0.80154927
131MP0000604_amyloidosis0.80074416
132MP0003045_fibrosis0.79573220
133MP0000733_abnormal_muscle_development0.79493682
134MP0003795_abnormal_bone_structure0.79195589
135MP0001216_abnormal_epidermal_layer0.78600311
136MP0002089_abnormal_postnatal_growth/wei0.77747240
137MP0005595_abnormal_vascular_smooth0.77675753
138MP0004130_abnormal_muscle_cell0.77283073
139MP0005621_abnormal_cell_physiology0.74639067

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)3.33079928
2Broad face (HP:0000283)3.32640038
3Polycythemia (HP:0001901)3.25317443
4Eczematoid dermatitis (HP:0000976)3.12131325
5Interstitial pulmonary disease (HP:0006530)3.01623621
6Abnormality of the nasal mucosa (HP:0000433)3.00052510
7Obstructive sleep apnea (HP:0002870)2.96689228
8Cerebral aneurysm (HP:0004944)2.96275599
9Petechiae (HP:0000967)2.94026124
10Muscle fiber splitting (HP:0003555)2.91869421
11Aortic aneurysm (HP:0004942)2.87881079
12Myocardial infarction (HP:0001658)2.79205175
13Pustule (HP:0200039)2.73020130
14Hematochezia (HP:0002573)2.70965407
15Tetraparesis (HP:0002273)2.69990159
16Premature rupture of membranes (HP:0001788)2.69830285
17Hyperacusis (HP:0010780)2.68088625
18Achilles tendon contracture (HP:0001771)2.65350636
19Dysostosis multiplex (HP:0000943)2.64518810
20Abnormality of liposaccharide metabolism (HP:0010968)2.64449661
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.64449661
22Abnormality of glycolipid metabolism (HP:0010969)2.64449661
23Elevated erythrocyte sedimentation rate (HP:0003565)2.62708886
24Autoimmune thrombocytopenia (HP:0001973)2.61875534
25Right ventricular cardiomyopathy (HP:0011663)2.61772856
26Protrusio acetabuli (HP:0003179)2.59604627
27Nasal polyposis (HP:0100582)2.58628691
28J-shaped sella turcica (HP:0002680)2.58570120
29Spontaneous hematomas (HP:0007420)2.55621785
30Chronic otitis media (HP:0000389)2.53498951
31Distal upper limb amyotrophy (HP:0007149)2.51636765
32Upper limb amyotrophy (HP:0009129)2.51636765
33Nuclear cataract (HP:0100018)2.51375899
34Difficulty climbing stairs (HP:0003551)2.51203380
35Ulnar bowing (HP:0003031)2.51079221
36Abnormal platelet volume (HP:0011876)2.47177601
37Impaired platelet aggregation (HP:0003540)2.46298884
38Abnormal platelet function (HP:0011869)2.46298884
39Prolonged bleeding time (HP:0003010)2.45519455
40Increased mean platelet volume (HP:0011877)2.44502248
41Increased IgE level (HP:0003212)2.42825680
42Abnormality of the Achilles tendon (HP:0005109)2.39495656
43Lower limb amyotrophy (HP:0007210)2.38225131
44Axonal loss (HP:0003447)2.37744629
45Mucopolysacchariduria (HP:0008155)2.36063723
46Urinary glycosaminoglycan excretion (HP:0003541)2.36063723
47Cellulitis (HP:0100658)2.33158083
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.33075991
49Osteolytic defects of the hand bones (HP:0009699)2.33075991
50Abnormality of polysaccharide metabolism (HP:0011012)2.32464067
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32464067
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32464067
53Hyporeflexia of lower limbs (HP:0002600)2.29563726
54Increased density of long bones (HP:0006392)2.29403183
55Aortic dissection (HP:0002647)2.29153550
56Poikilocytosis (HP:0004447)2.28488589
57Ventricular tachycardia (HP:0004756)2.27045352
58Stridor (HP:0010307)2.24582890
59Increased variability in muscle fiber diameter (HP:0003557)2.21923822
60Distal lower limb amyotrophy (HP:0008944)2.20794489
61Myositis (HP:0100614)2.20561405
62Recurrent viral infections (HP:0004429)2.20008236
63Emphysema (HP:0002097)2.19054587
64Malnutrition (HP:0004395)2.17820193
65Recurrent fungal infections (HP:0002841)2.17712002
66Peritonitis (HP:0002586)2.17090359
67Epistaxis (HP:0000421)2.16637878
68Hemorrhage of the eye (HP:0011885)2.15269419
69Recurrent abscess formation (HP:0002722)2.14844045
70Joint stiffness (HP:0001387)2.14420414
71Mitral regurgitation (HP:0001653)2.14404077
72Shallow orbits (HP:0000586)2.12370082
73Flat acetabular roof (HP:0003180)2.10579289
74Dilatation of the ascending aorta (HP:0005111)2.10452309
75Thrombocytosis (HP:0001894)2.08827119
76Distal lower limb muscle weakness (HP:0009053)2.07844798
77Mildly elevated creatine phosphokinase (HP:0008180)2.07803876
78Increased serum ferritin (HP:0003281)2.07037798
79Menorrhagia (HP:0000132)2.06981547
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.06527816
81Aneurysm (HP:0002617)2.05997306
82Abnormality of skeletal muscle fiber size (HP:0012084)2.05977973
83Colitis (HP:0002583)2.03394400
84Wormian bones (HP:0002645)2.02940475
85Vertebral compression fractures (HP:0002953)2.01847204
86Diaphragmatic weakness (HP:0009113)2.01131479
87Persistence of primary teeth (HP:0006335)2.00818220
88Short nail (HP:0001799)2.00325039
89Reticulocytosis (HP:0001923)1.99608325
90Facial diplegia (HP:0001349)1.98598101
91Orchitis (HP:0100796)1.95373625
92Blue sclerae (HP:0000592)1.95288012
93Mitral valve prolapse (HP:0001634)1.94880223
94Asymmetric septal hypertrophy (HP:0001670)1.94612744
95Aortic regurgitation (HP:0001659)1.93175454
96Exercise-induced myalgia (HP:0003738)1.93124942
97Gingival bleeding (HP:0000225)1.93073581
98Recurrent bacterial skin infections (HP:0005406)1.92793705
99Rectal prolapse (HP:0002035)1.92540606
100Loss of speech (HP:0002371)1.91862084
101Nonimmune hydrops fetalis (HP:0001790)1.90703957
102Atrophic scars (HP:0001075)1.89045277
103Segmental peripheral demyelination/remyelination (HP:0003481)1.87913301
104Recurrent bronchitis (HP:0002837)1.87760560
105Arterial thrombosis (HP:0004420)1.86081517
106Neurofibrillary tangles (HP:0002185)1.84591691
107Cerebral inclusion bodies (HP:0100314)1.84364420
108Disproportionate tall stature (HP:0001519)1.84278259
109Esophageal varix (HP:0002040)1.84070482
110Abnormality of iron homeostasis (HP:0011031)1.83767912
111Cervical subluxation (HP:0003308)1.83370061
112Lipoatrophy (HP:0100578)1.83047815
113Myopathic facies (HP:0002058)1.82700273
114Biconcave vertebral bodies (HP:0004586)1.82212647
115Abnormality of the heme biosynthetic pathway (HP:0010472)1.81987282
116Abnormality of the distal phalanges of the toes (HP:0010182)1.80113829
117Abnormality of proline metabolism (HP:0010907)1.79362423
118Hydroxyprolinuria (HP:0003080)1.79362423
119Round ear (HP:0100830)1.77866861
120Spondylolisthesis (HP:0003302)1.77303512
121Increased cerebral lipofuscin (HP:0011813)1.76967192
122Thin bony cortex (HP:0002753)1.75757791
123Elbow flexion contracture (HP:0002987)1.75515927
124Inflammation of the large intestine (HP:0002037)1.75063248
125Ankle contracture (HP:0006466)1.74619438
126Broad metatarsal (HP:0001783)1.74573740
127Fragile skin (HP:0001030)1.74434229
128Limb-girdle muscle atrophy (HP:0003797)1.73175169
129Genu recurvatum (HP:0002816)1.72724536
130Gastrointestinal inflammation (HP:0004386)1.72162178
131Reduced subcutaneous adipose tissue (HP:0003758)1.71175784
132Mesangial abnormality (HP:0001966)1.70592729
133Abnormality of macrophages (HP:0004311)1.70476153
134Subacute progressive viral hepatitis (HP:0006572)1.70420414
135Arterial tortuosity (HP:0005116)1.70362433
136Bicuspid aortic valve (HP:0001647)1.70138558
137Onion bulb formation (HP:0003383)1.69716334
138Vascular tortuosity (HP:0004948)1.69414389
139Bladder diverticulum (HP:0000015)1.68934190
140Bulbar palsy (HP:0001283)1.68854198
141Long palpebral fissure (HP:0000637)1.68773695
142Spinal rigidity (HP:0003306)1.68434910
143Acanthosis nigricans (HP:0000956)1.68429666
144Hypertriglyceridemia (HP:0002155)1.68337170
145Purpura (HP:0000979)1.67869164
146Abnormality of transition element cation homeostasis (HP:0011030)1.67049987
147Vasculitis (HP:0002633)1.66970937
148Nephritis (HP:0000123)1.66702533
149Recurrent gram-negative bacterial infections (HP:0005420)1.66700825
150Type 1 muscle fiber predominance (HP:0003803)1.66351170
151Abnormality of the fingertips (HP:0001211)1.66052699
152IgM deficiency (HP:0002850)1.63802532
153Acanthocytosis (HP:0001927)1.63425571
154EMG: myopathic abnormalities (HP:0003458)1.63192019
155Deformed sella turcica (HP:0002681)1.63133380
156Mediastinal lymphadenopathy (HP:0100721)1.63073254
157Increased neuronal autofluorescent lipopigment (HP:0002074)1.63009240
158Abnormality of the thoracic spine (HP:0100711)1.62762442
159Bone pain (HP:0002653)1.61853508
160Easy fatigability (HP:0003388)1.60621393
161Generalized amyotrophy (HP:0003700)1.60362811
162Advanced eruption of teeth (HP:0006288)1.60254775
163Natal tooth (HP:0000695)1.58905190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.21652881
2ERN13.12731580
3TRIB33.05676395
4MAP4K12.70100653
5TTN2.41177822
6TBK12.38857246
7EPHB12.24730964
8ICK2.22138601
9EEF2K2.20574963
10TYK22.18328224
11FGFR42.16878501
12MAP3K102.13409734
13TGFBR22.09748066
14MAP3K32.04879829
15PKN22.03818231
16SMG11.95652321
17STK101.93127862
18JAK31.92022806
19MAP3K141.91971962
20PIM21.75879525
21RIPK11.74807970
22LRRK21.70430160
23TAOK21.64390593
24TIE11.61081847
25IKBKB1.59624918
26IKBKE1.56473227
27EPHA31.55113434
28MAP2K31.54901718
29MAP3K131.54493554
30ZAP701.53414092
31PTK61.48662571
32MAPKAPK31.43589508
33RPS6KA41.41130335
34JAK11.40043921
35TAOK31.37265384
36KDR1.35495198
37DMPK1.32320390
38CDC42BPA1.29473030
39KIT1.29321402
40CHUK1.29304988
41NME21.24207491
42PIM11.22327459
43MARK21.22184398
44TRPM71.17507418
45MST41.17169881
46ITK1.16124323
47IRAK31.15409961
48LATS21.15166297
49TESK11.14749687
50PRKD21.11556277
51MAP3K61.10395253
52FLT31.08330654
53CSK1.07375912
54DDR21.06271324
55BTK1.05178819
56MAP3K111.03876405
57FGFR31.03008729
58SIK11.01664103
59MST1R1.01072927
60MET0.99773521
61CDK120.96011033
62PDPK10.94239543
63TAOK10.94201216
64RPS6KA20.92410849
65PAK20.91718701
66TEC0.90041059
67BMX0.89590178
68TGFBR10.87527818
69JAK20.87063985
70EPHA20.85059935
71HCK0.83727468
72PDGFRA0.80634814
73GRK60.80562741
74MAPK150.80529857
75MAPK120.79909310
76NLK0.79810557
77RPS6KB20.79033579
78LMTK20.77755015
79MAP2K20.77203976
80SYK0.76533877
81MYLK0.75660101
82BLK0.75488522
83IRAK20.74603666
84MARK30.73293377
85TXK0.73148102
86SIK30.69415822
87MAPKAPK20.67271572
88ARAF0.66330630
89RIPK40.65926687
90MAPK110.65725648
91HIPK20.65364498
92STK40.64932044
93DYRK1B0.64718578
94PDGFRB0.64127894
95SIK20.62899035
96PRKG20.62810074
97PAK40.62449626
98STK380.61577554
99MAP3K70.61559774
100MTOR0.59741384
101MAPK70.58903194
102KSR20.57980036
103MAP2K60.57794735
104MAP3K10.57631173
105LCK0.57218894
106NTRK10.55080238
107STK30.55063459
108CDK60.54641238
109STK240.53363556
110RPS6KA60.53319256
111MAP3K80.51697526
112MAPK40.50774402
113DYRK30.50490441
114NEK90.49637008
115PTK20.49430088
116PDK10.48664372
117ABL20.47840541
118TNK20.47348381
119MOS0.47289118
120GSK3A0.47253278
121CSF1R0.47141558
122CAMK1D0.44338831
123PRKAA20.44168817
124RPS6KC10.41821599
125RPS6KL10.41821599
126ILK0.41688606
127RPS6KA50.40912187
128MAP3K90.40223677
129ABL10.38877362
130IRAK40.38452783
131SCYL20.38411763
132RPS6KA10.38094369
133PRKD30.37978173
134CDK90.37846601
135PRKD10.37119058
136CDK40.37094067
137EPHB20.37053519
138IRAK10.33214891
139CAMKK10.32079046

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.36589460
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.30795544
3Osteoclast differentiation_Homo sapiens_hsa043802.19388700
4Malaria_Homo sapiens_hsa051442.16744124
5Toxoplasmosis_Homo sapiens_hsa051451.93613648
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83240218
7Measles_Homo sapiens_hsa051621.82796338
8TNF signaling pathway_Homo sapiens_hsa046681.82194131
9Antigen processing and presentation_Homo sapiens_hsa046121.81748937
10Legionellosis_Homo sapiens_hsa051341.75653140
11Small cell lung cancer_Homo sapiens_hsa052221.74351826
12Hematopoietic cell lineage_Homo sapiens_hsa046401.72970571
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70591473
14B cell receptor signaling pathway_Homo sapiens_hsa046621.67087614
15Caffeine metabolism_Homo sapiens_hsa002321.66365619
16ECM-receptor interaction_Homo sapiens_hsa045121.64122455
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63515339
18Apoptosis_Homo sapiens_hsa042101.62474944
19Chronic myeloid leukemia_Homo sapiens_hsa052201.53544932
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.53418454
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.50414917
22Acute myeloid leukemia_Homo sapiens_hsa052211.50103756
23Primary immunodeficiency_Homo sapiens_hsa053401.45082534
24Influenza A_Homo sapiens_hsa051641.43829407
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.43355402
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42456605
27Viral myocarditis_Homo sapiens_hsa054161.41623755
28Herpes simplex infection_Homo sapiens_hsa051681.37229076
29Staphylococcus aureus infection_Homo sapiens_hsa051501.35323435
30Focal adhesion_Homo sapiens_hsa045101.32052094
31Amoebiasis_Homo sapiens_hsa051461.31327697
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.28668238
33Pertussis_Homo sapiens_hsa051331.27397693
34Prion diseases_Homo sapiens_hsa050201.26299403
35Fructose and mannose metabolism_Homo sapiens_hsa000511.25708749
36Hepatitis B_Homo sapiens_hsa051611.25237359
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23005623
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20351171
39Insulin resistance_Homo sapiens_hsa049311.19610572
40Non-small cell lung cancer_Homo sapiens_hsa052231.18493107
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.16219753
42Renal cell carcinoma_Homo sapiens_hsa052111.14937587
43mTOR signaling pathway_Homo sapiens_hsa041501.14852530
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14182214
45GnRH signaling pathway_Homo sapiens_hsa049121.12543771
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12411571
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12179729
48Platelet activation_Homo sapiens_hsa046111.09610661
49Tuberculosis_Homo sapiens_hsa051521.08562846
50T cell receptor signaling pathway_Homo sapiens_hsa046601.06596393
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06189179
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06121498
53Insulin signaling pathway_Homo sapiens_hsa049101.05153529
54Shigellosis_Homo sapiens_hsa051311.04605429
55Hepatitis C_Homo sapiens_hsa051601.04346188
56Bladder cancer_Homo sapiens_hsa052191.03309689
57Proteoglycans in cancer_Homo sapiens_hsa052051.02347992
58Salmonella infection_Homo sapiens_hsa051321.01262109
59Galactose metabolism_Homo sapiens_hsa000521.00673563
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00524936
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99080551
62Pancreatic cancer_Homo sapiens_hsa052120.97524718
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.95887279
64HTLV-I infection_Homo sapiens_hsa051660.95807847
65Viral carcinogenesis_Homo sapiens_hsa052030.93082545
66Endometrial cancer_Homo sapiens_hsa052130.92976090
67Prolactin signaling pathway_Homo sapiens_hsa049170.91004116
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90437731
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89983236
70p53 signaling pathway_Homo sapiens_hsa041150.89337448
71ErbB signaling pathway_Homo sapiens_hsa040120.89250508
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89188333
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88960205
74MicroRNAs in cancer_Homo sapiens_hsa052060.88534813
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86962309
76Notch signaling pathway_Homo sapiens_hsa043300.86079612
77Glioma_Homo sapiens_hsa052140.85671491
78Pentose phosphate pathway_Homo sapiens_hsa000300.85558373
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84332055
80Complement and coagulation cascades_Homo sapiens_hsa046100.83125587
81Adherens junction_Homo sapiens_hsa045200.82426712
82Endocytosis_Homo sapiens_hsa041440.81424326
83Graft-versus-host disease_Homo sapiens_hsa053320.81309114
84HIF-1 signaling pathway_Homo sapiens_hsa040660.80383017
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77151881
86Dilated cardiomyopathy_Homo sapiens_hsa054140.77069320
87AMPK signaling pathway_Homo sapiens_hsa041520.76290675
88Other glycan degradation_Homo sapiens_hsa005110.75140251
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75049932
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74286610
91Choline metabolism in cancer_Homo sapiens_hsa052310.73579561
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72960541
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72803522
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72745811
95Protein digestion and absorption_Homo sapiens_hsa049740.72187229
96Estrogen signaling pathway_Homo sapiens_hsa049150.71988966
97Allograft rejection_Homo sapiens_hsa053300.71459129
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71452831
99Inositol phosphate metabolism_Homo sapiens_hsa005620.70066293
100Lysosome_Homo sapiens_hsa041420.69821299
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68965539
102ABC transporters_Homo sapiens_hsa020100.68791069
103MAPK signaling pathway_Homo sapiens_hsa040100.68057031
104Chemokine signaling pathway_Homo sapiens_hsa040620.67775014
105FoxO signaling pathway_Homo sapiens_hsa040680.64657840
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.64563215
107Renin-angiotensin system_Homo sapiens_hsa046140.61009671
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60416037
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60064353
110VEGF signaling pathway_Homo sapiens_hsa043700.58343593
111African trypanosomiasis_Homo sapiens_hsa051430.57663922
112Epstein-Barr virus infection_Homo sapiens_hsa051690.56850439
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56285779
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.54188958
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53282598
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53281525
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52692693
118Fatty acid degradation_Homo sapiens_hsa000710.52539141
119Prostate cancer_Homo sapiens_hsa052150.52391700
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52371869
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.52203624
122PPAR signaling pathway_Homo sapiens_hsa033200.49888872
123Thyroid cancer_Homo sapiens_hsa052160.49615749
124TGF-beta signaling pathway_Homo sapiens_hsa043500.49275882
125Lysine degradation_Homo sapiens_hsa003100.49061458
126Pathways in cancer_Homo sapiens_hsa052000.48626602
127Dorso-ventral axis formation_Homo sapiens_hsa043200.46776314
128Asthma_Homo sapiens_hsa053100.43382891
129Fat digestion and absorption_Homo sapiens_hsa049750.43089449
130Rheumatoid arthritis_Homo sapiens_hsa053230.42747104
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40419620
132Starch and sucrose metabolism_Homo sapiens_hsa005000.40417181

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