MAFF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.73225860
2regulation of DNA endoreduplication (GO:0032875)6.72459560
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.34614593
4membrane repolarization during action potential (GO:0086011)6.11452493
5regulation of cell proliferation involved in kidney development (GO:1901722)6.02721119
6regulation of glomerulus development (GO:0090192)5.69187231
7positive regulation of synapse maturation (GO:0090129)5.23787976
8behavioral response to nicotine (GO:0035095)5.06379270
9positive regulation of p38MAPK cascade (GO:1900745)4.97646452
10positive regulation of male gonad development (GO:2000020)4.81844111
11fat-soluble vitamin catabolic process (GO:0042363)4.69839887
12vitamin catabolic process (GO:0009111)4.69839887
13regulation of skeletal muscle contraction (GO:0014819)4.61233874
14ribosomal small subunit biogenesis (GO:0042274)4.49565319
15positive regulation of heat generation (GO:0031652)4.47328662
16regulation of synapse maturation (GO:0090128)4.43274722
17viral transcription (GO:0019083)4.39359575
18regulation of fever generation (GO:0031620)4.37215758
19cellular potassium ion homeostasis (GO:0030007)4.34730995
20negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.32626993
21positive regulation of metanephros development (GO:0072216)4.30087815
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26545350
23membrane repolarization (GO:0086009)4.20284711
24response to muramyl dipeptide (GO:0032495)4.18156444
25cellular response to electrical stimulus (GO:0071257)4.13920591
26translational termination (GO:0006415)4.13486764
27negative regulation of macrophage differentiation (GO:0045650)4.12775546
28flavonoid metabolic process (GO:0009812)4.04617189
29regulation of male gonad development (GO:2000018)4.02922449
30regulation of p38MAPK cascade (GO:1900744)4.00078645
31cellular response to zinc ion (GO:0071294)3.99352143
32regulation of membrane repolarization (GO:0060306)3.98363207
33negative regulation of systemic arterial blood pressure (GO:0003085)3.91209215
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90929280
35ATP synthesis coupled proton transport (GO:0015986)3.90929280
36magnesium ion transport (GO:0015693)3.87348521
37regulation of interleukin-12 biosynthetic process (GO:0045075)3.81541719
38NIK/NF-kappaB signaling (GO:0038061)3.81458351
39cell proliferation in forebrain (GO:0021846)3.79344830
40cellular anion homeostasis (GO:0030002)3.79231680
41endoderm formation (GO:0001706)3.75130310
42cell adhesion mediated by integrin (GO:0033627)3.66990374
43negative regulation of metanephros development (GO:0072217)3.63931955
44negative regulation of protein localization to cell surface (GO:2000009)3.60753720
45retinal ganglion cell axon guidance (GO:0031290)3.59695030
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54493587
47regulation of female gonad development (GO:2000194)3.53036831
48protein complex biogenesis (GO:0070271)3.52479642
49sulfation (GO:0051923)3.50508680
50cellular response to ATP (GO:0071318)3.47263080
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.47195596
52NADH dehydrogenase complex assembly (GO:0010257)3.47195596
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47195596
54mitochondrial respiratory chain complex assembly (GO:0033108)3.46448052
55wound healing, spreading of epidermal cells (GO:0035313)3.44998691
56cellular response to exogenous dsRNA (GO:0071360)3.43732040
57regulation of mesoderm development (GO:2000380)3.43553434
58response to electrical stimulus (GO:0051602)3.42625751
59mesonephros development (GO:0001823)3.42283539
60diaphragm development (GO:0060539)3.41743172
61skeletal muscle organ development (GO:0060538)3.40658026
62regulation of heat generation (GO:0031650)3.39494898
63water-soluble vitamin biosynthetic process (GO:0042364)3.39426353
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.37712916
65DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.36924570
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.34157184
67response to xenobiotic stimulus (GO:0009410)3.34153072
68regulation of podosome assembly (GO:0071801)3.30023448
69cotranslational protein targeting to membrane (GO:0006613)3.27875926
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27422360
71activation of MAPKKK activity (GO:0000185)3.27234704
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26505697
73protein targeting to ER (GO:0045047)3.26122678
74negative regulation of fatty acid transport (GO:2000192)3.24570579
75vitamin D metabolic process (GO:0042359)3.23948151
76viral life cycle (GO:0019058)3.22655418
77negative regulation of response to food (GO:0032096)3.22140018
78negative regulation of appetite (GO:0032099)3.22140018
79positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.16884181
80regulation of potassium ion transmembrane transport (GO:1901379)3.15607554
81translational elongation (GO:0006414)3.14660511
82chaperone-mediated protein transport (GO:0072321)3.14400921
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.12962271
84endothelial cell chemotaxis (GO:0035767)3.12266922
85phenol-containing compound catabolic process (GO:0019336)3.11525122
86protein localization to endoplasmic reticulum (GO:0070972)3.09196328
87low-density lipoprotein particle clearance (GO:0034383)3.08712802
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08481696
89regulation of gonadotropin secretion (GO:0032276)3.08430859
90positive regulation of chemokine biosynthetic process (GO:0045080)3.07787289
91skin morphogenesis (GO:0043589)3.05478889
92DNA deamination (GO:0045006)3.03271722
93positive regulation by symbiont of host defense response (GO:0052509)3.01992844
94modulation by symbiont of host defense response (GO:0052031)3.01992844
95modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01992844
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01992844
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.01992844
98modulation by symbiont of host immune response (GO:0052553)3.01992844
99fusion of sperm to egg plasma membrane (GO:0007342)2.97838746
100piRNA metabolic process (GO:0034587)2.97323192
101positive regulation of cAMP-mediated signaling (GO:0043950)2.96933358
102negative regulation of potassium ion transmembrane transport (GO:1901380)2.95498438
103phosphate ion homeostasis (GO:0055062)2.95321480
104trivalent inorganic anion homeostasis (GO:0072506)2.95321480
105protein neddylation (GO:0045116)2.95271820
106interferon-gamma secretion (GO:0072643)2.95098979
107seminiferous tubule development (GO:0072520)2.94771652
108response to progesterone (GO:0032570)2.94393606
109positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.93213514
110cell migration involved in sprouting angiogenesis (GO:0002042)2.92875242
111cellular protein complex disassembly (GO:0043624)2.92839085
112metanephric mesenchyme development (GO:0072075)2.91793792
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91499329
114regulation of chronic inflammatory response (GO:0002676)2.89263022
115endocardial cushion development (GO:0003197)2.88826165
116hemidesmosome assembly (GO:0031581)2.86236901
117negative regulation of lipid storage (GO:0010888)2.85312330
118phenylpropanoid metabolic process (GO:0009698)2.84140413
119DNA damage response, signal transduction resulting in transcription (GO:0042772)2.84071098
120regulation of vitamin D biosynthetic process (GO:0060556)2.83155037
121mesodermal cell differentiation (GO:0048333)2.82451201
122cellular response to gonadotropin stimulus (GO:0071371)2.81859140
123glomerulus development (GO:0032835)2.80891779
124potassium ion import (GO:0010107)2.80582137
125positive regulation of meiotic cell cycle (GO:0051446)2.79891025
126growth hormone receptor signaling pathway (GO:0060396)2.77859459
127negative regulation of interleukin-12 production (GO:0032695)2.77769971
128regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77354888
129* parturition (GO:0007567)2.75695849
130regulation of metanephros development (GO:0072215)2.75078570
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.74695823
132sex determination (GO:0007530)2.73901284
133neutrophil activation involved in immune response (GO:0002283)2.73282804
134labyrinthine layer development (GO:0060711)2.72655914
135positive regulation of meiosis (GO:0045836)2.71982317
136establishment of endothelial barrier (GO:0061028)2.70035189
137regulation of heart rate by cardiac conduction (GO:0086091)2.68918650
138positive regulation of protein homodimerization activity (GO:0090073)2.68871343
139wound healing, spreading of cells (GO:0044319)2.68240965
140serotonin metabolic process (GO:0042428)2.67316146
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64801502
142positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63533572
143regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62468804
144negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.60409779
145vitamin A metabolic process (GO:0006776)2.58955823
146T-helper cell differentiation (GO:0042093)2.55425882
147CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.55425882
148positive regulation of astrocyte differentiation (GO:0048711)2.54918179
149interleukin-1-mediated signaling pathway (GO:0070498)2.54783249
150response to laminar fluid shear stress (GO:0034616)2.53187094
151regulation of gamma-delta T cell activation (GO:0046643)2.51449583
152regulation of vitamin metabolic process (GO:0030656)2.50564116
153myeloid dendritic cell differentiation (GO:0043011)2.49662158
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49324273
155apoptotic cell clearance (GO:0043277)2.48043944
156mammary gland epithelial cell proliferation (GO:0033598)2.45132031
157blood vessel endothelial cell migration (GO:0043534)2.42582388
158response to peptidoglycan (GO:0032494)2.41678316
159tyrosine phosphorylation of STAT protein (GO:0007260)2.41360414
160cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41136583
161cellular response to arsenic-containing substance (GO:0071243)2.40395246
162hepatocyte apoptotic process (GO:0097284)2.40057521
163positive thymic T cell selection (GO:0045059)2.39976460
164decidualization (GO:0046697)2.39767520
165negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.39611358
166monocyte chemotaxis (GO:0002548)2.39144949
167regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.38418803
168regulation of cholesterol homeostasis (GO:2000188)2.37806543
169positive regulation of lipid storage (GO:0010884)2.37440301
170cellular response to nicotine (GO:0071316)2.37322524
171macrophage activation involved in immune response (GO:0002281)2.37248943
172lung vasculature development (GO:0060426)2.36142027
173tolerance induction (GO:0002507)2.36021459
174regulation of gamma-delta T cell differentiation (GO:0045586)2.35225693
175cytokine secretion (GO:0050663)2.34368444
176granulocyte activation (GO:0036230)2.33897660
177cellular response to growth hormone stimulus (GO:0071378)2.32502150
178regulation of integrin activation (GO:0033623)2.31997701
179positive regulation of interleukin-12 production (GO:0032735)2.31772262
180negative regulation of smooth muscle cell migration (GO:0014912)2.31036509
181platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29592395
182regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.27589117
183positive regulation of endothelial cell apoptotic process (GO:2000353)2.27318318
184tumor necrosis factor-mediated signaling pathway (GO:0033209)2.26748681
185positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.26692306
186regulation of chemokine biosynthetic process (GO:0045073)2.26647265
187regulation of interleukin-12 production (GO:0032655)2.26478928
188leukocyte aggregation (GO:0070486)2.26431142
189positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25090953
190positive regulation of osteoclast differentiation (GO:0045672)2.24809361
191positive regulation of bone resorption (GO:0045780)2.21700985
192positive regulation of bone remodeling (GO:0046852)2.21700985
193positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.21123349
194leukocyte cell-cell adhesion (GO:0007159)2.20763067
195myeloid dendritic cell activation (GO:0001773)2.20445102
196regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.18864093
197neutrophil activation (GO:0042119)2.18537882
198regulation of heterotypic cell-cell adhesion (GO:0034114)2.18402985
199positive regulation of gamma-delta T cell activation (GO:0046645)2.17241696
200regulation of dendritic cell antigen processing and presentation (GO:0002604)2.15915812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.87585077
2EZH2_22144423_ChIP-Seq_EOC_Human5.59041726
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.19276272
4EGR1_19374776_ChIP-ChIP_THP-1_Human5.09846972
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.09187239
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.34859846
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63594164
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36925095
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23881005
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.23837277
11IRF1_19129219_ChIP-ChIP_H3396_Human3.16482397
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.15461358
13CLOCK_20551151_ChIP-Seq_293T_Human2.69173977
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.69030022
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.68086762
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60338640
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56445810
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48856161
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.47622987
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.44569238
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.42202015
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41635054
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.39906034
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.31321261
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26780029
26VDR_22108803_ChIP-Seq_LS180_Human2.20320653
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18676253
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.13602239
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05312964
30CBX2_27304074_Chip-Seq_ESCs_Mouse2.04212343
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.03845063
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01803912
33JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00866613
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00132907
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97758636
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.94268291
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90997669
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89065408
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89065408
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.83546159
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83135955
42* FOXO3_23340844_ChIP-Seq_DLD1_Human1.82213538
43RNF2_27304074_Chip-Seq_NSC_Mouse1.82054397
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.80339627
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.76366352
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.74078705
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72000013
48EWS_26573619_Chip-Seq_HEK293_Human1.68628808
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66632606
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66519313
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63955124
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62793980
53RUNX_20019798_ChIP-Seq_JUKART_Human1.61585631
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60007212
55* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57392930
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56933809
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56869000
58IGF1R_20145208_ChIP-Seq_DFB_Human1.56339645
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55251361
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.54900224
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54832658
62CJUN_26792858_Chip-Seq_BT549_Human1.54504606
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.54344888
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54311888
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53166628
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52569787
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52375909
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52293470
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52219880
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51341679
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.50354685
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50343966
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50343966
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49277244
75* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49209448
76MAF_26560356_Chip-Seq_TH1_Human1.48738477
77ATF3_27146783_Chip-Seq_COLON_Human1.48369368
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.48313620
79* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46871730
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46006749
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45480045
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45365425
83* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44841665
84GBX2_23144817_ChIP-Seq_PC3_Human1.44779351
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.44622328
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.41559052
87ZNF263_19887448_ChIP-Seq_K562_Human1.41178194
88MYC_22102868_ChIP-Seq_BL_Human1.40456839
89VDR_24763502_ChIP-Seq_THP-1_Human1.38736729
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.38433652
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38332753
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37721291
93REST_21632747_ChIP-Seq_MESCs_Mouse1.37684020
94VDR_24787735_ChIP-Seq_THP-1_Human1.35065363
95MYB_26560356_Chip-Seq_TH2_Human1.34935658
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34761115
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.33612507
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31983900
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31384035
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31331631
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.31195216
102SCL_19346495_ChIP-Seq_HPC-7_Human1.31089705
103* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30933089
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30768575
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29893045
106KDM2B_26808549_Chip-Seq_DND41_Human1.29775506
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29449545
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28267910
109MYC_18940864_ChIP-ChIP_HL60_Human1.26032825
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24482036
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23767564
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23551632
113SOX2_20726797_ChIP-Seq_SW620_Human1.23392823
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22995915
115* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22207558
116* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21685821
117* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19349022
118MYB_26560356_Chip-Seq_TH1_Human1.18080022
119NCOR_22424771_ChIP-Seq_293T_Human1.18060805
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17950681
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17796287
122TAF15_26573619_Chip-Seq_HEK293_Human1.17589536
123ZNF274_21170338_ChIP-Seq_K562_Hela1.17293037
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16837703
125VDR_21846776_ChIP-Seq_THP-1_Human1.16254388
126RACK7_27058665_Chip-Seq_MCF-7_Human1.14691707
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14026734
128* BRD4_25478319_ChIP-Seq_HGPS_Human1.13514533
129CDX2_20551321_ChIP-Seq_CACO-2_Human1.12229850
130* RUNX1_22412390_ChIP-Seq_EML_Mouse1.11951610
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11475304
132P300_19829295_ChIP-Seq_ESCs_Human1.10912067
133* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10568232
134* FOXA1_25329375_ChIP-Seq_VCAP_Human1.10568232
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10242516
136GATA3_21878914_ChIP-Seq_MCF-7_Human1.09910741
137LXR_22158963_ChIP-Seq_LIVER_Mouse1.09827900
138ER_23166858_ChIP-Seq_MCF-7_Human1.09716712
139MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09575757
140RUNX1_27514584_Chip-Seq_MCF-7_Human1.08697064
141UTX_26944678_Chip-Seq_JUKART_Human1.08251045
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08203506
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06234045
144TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05775684
145SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04747209
146AR_25329375_ChIP-Seq_VCAP_Human1.04423576
147CBP_20019798_ChIP-Seq_JUKART_Human1.03523416
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03523416
149POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03328514
150RING1B_27294783_Chip-Seq_ESCs_Mouse1.03243703
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01247751
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99886924
153KLF5_25053715_ChIP-Seq_YYC3_Human0.99574836
154KDM2B_26808549_Chip-Seq_JURKAT_Human0.99569841
155NCOR1_26117541_ChIP-Seq_K562_Human0.99479608
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99425481
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99079606
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98115473
159GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97843567
160TP53_16413492_ChIP-PET_HCT116_Human0.97657314
161JUN_21703547_ChIP-Seq_K562_Human0.97425027
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97247186
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.96338029
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95993468
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95993468
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95683610
167GATA6_25053715_ChIP-Seq_YYC3_Human0.95178232
168PU_27001747_Chip-Seq_BMDM_Mouse0.94987300
169ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93961498
170NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93892629
171KDM2B_26808549_Chip-Seq_K562_Human0.93851028
172SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93727942
173P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93710799
174E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93669322
175REST_18959480_ChIP-ChIP_MESCs_Mouse0.92984253
176TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92841802
177AHR_22903824_ChIP-Seq_MCF-7_Human0.91740018
178LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90502129
179TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90362232
180EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89168416
181PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87442237
182AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87252407
183BCAT_22108803_ChIP-Seq_LS180_Human0.86725863
184SOX2_19829295_ChIP-Seq_ESCs_Human0.86564155
185NANOG_19829295_ChIP-Seq_ESCs_Human0.86564155
186SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86275003
187PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85709341
188TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85627518
189SMAD4_21741376_ChIP-Seq_EPCs_Human0.85433405
190EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83685780
191FOXH1_21741376_ChIP-Seq_EPCs_Human0.83514422
192HTT_18923047_ChIP-ChIP_STHdh_Human0.83275467
193FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82959153
194ELK1_19687146_ChIP-ChIP_HELA_Human0.82540667
195MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81524434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.17290034
2MP0002160_abnormal_reproductive_system3.59329614
3MP0008877_abnormal_DNA_methylation3.15513644
4MP0003806_abnormal_nucleotide_metabolis3.13311330
5MP0005389_reproductive_system_phenotype3.01486483
6MP0003303_peritoneal_inflammation2.95279081
7MP0004510_myositis2.84929203
8MP0001440_abnormal_grooming_behavior2.82597725
9MP0003724_increased_susceptibility_to2.76423123
10MP0010352_gastrointestinal_tract_polyps2.68272715
11MP0003646_muscle_fatigue2.61655609
12MP0003436_decreased_susceptibility_to2.60615244
13MP0002877_abnormal_melanocyte_morpholog2.60372545
14MP0004947_skin_inflammation2.47789943
15MP0005076_abnormal_cell_differentiation2.44547186
16MP0002837_dystrophic_cardiac_calcinosis2.38025487
17MP0003300_gastrointestinal_ulcer2.37754404
18MP0003566_abnormal_cell_adhesion2.36928185
19MP0002938_white_spotting2.34647278
20MP0006292_abnormal_olfactory_placode2.29118446
21MP0003453_abnormal_keratinocyte_physiol2.26179562
22MP0005646_abnormal_pituitary_gland2.24291462
23MP0001542_abnormal_bone_strength2.17499761
24MP0003879_abnormal_hair_cell2.16017568
25MP0002254_reproductive_system_inflammat2.10684565
26MP0009278_abnormal_bone_marrow2.10650325
27MP0008995_early_reproductive_senescence2.08323673
28MP0003705_abnormal_hypodermis_morpholog2.06982425
29MP0003123_paternal_imprinting2.04085244
30MP0000685_abnormal_immune_system1.99124766
31MP0005000_abnormal_immune_tolerance1.98720610
32MP0001919_abnormal_reproductive_system1.97545567
33MP0004019_abnormal_vitamin_homeostasis1.96098513
34MP0009785_altered_susceptibility_to1.95391983
35MP0001485_abnormal_pinna_reflex1.90560959
36MP0004885_abnormal_endolymph1.85751034
37MP0001790_abnormal_immune_system1.85108265
38MP0005387_immune_system_phenotype1.85108265
39MP0000678_abnormal_parathyroid_gland1.84939724
40MP0002405_respiratory_system_inflammati1.83895049
41MP0002138_abnormal_hepatobiliary_system1.83596006
42MP0001533_abnormal_skeleton_physiology1.81098987
43MP0005023_abnormal_wound_healing1.77615869
44MP0008438_abnormal_cutaneous_collagen1.75332532
45MP0004145_abnormal_muscle_electrophysio1.75255872
46MP0002419_abnormal_innate_immunity1.74594950
47MP0009384_cardiac_valve_regurgitation1.73861881
48MP0003448_altered_tumor_morphology1.72289533
49MP0008875_abnormal_xenobiotic_pharmacok1.72085389
50MP0003011_delayed_dark_adaptation1.68542994
51MP0003942_abnormal_urinary_system1.65377588
52MP0001853_heart_inflammation1.65143810
53MP0003091_abnormal_cell_migration1.63849044
54MP0005257_abnormal_intraocular_pressure1.61485911
55MP0004130_abnormal_muscle_cell1.60576129
56MP0002452_abnormal_antigen_presenting1.59022950
57MP0002998_abnormal_bone_remodeling1.58319085
58MP0010386_abnormal_urinary_bladder1.57822217
59MP0005423_abnormal_somatic_nervous1.57435827
60MP0002272_abnormal_nervous_system1.53709351
61MP0001835_abnormal_antigen_presentation1.53653730
62MP0003828_pulmonary_edema1.53598473
63MP0000858_altered_metastatic_potential1.53340546
64MP0001851_eye_inflammation1.53329883
65MP0002148_abnormal_hypersensitivity_rea1.53144052
66MP0005275_abnormal_skin_tensile1.51505720
67MP0002723_abnormal_immune_serum1.51397943
68MP0000569_abnormal_digit_pigmentation1.51314506
69MP0001958_emphysema1.51249600
70MP0010155_abnormal_intestine_physiology1.51159985
71MP0002060_abnormal_skin_morphology1.48410854
72MP0001800_abnormal_humoral_immune1.48206357
73MP0000049_abnormal_middle_ear1.47108220
74MP0002933_joint_inflammation1.47007762
75MP0009745_abnormal_behavioral_response1.43404030
76MP0004142_abnormal_muscle_tone1.42655137
77MP0005410_abnormal_fertilization1.42090233
78MP0005025_abnormal_response_to1.40675415
79MP0002876_abnormal_thyroid_physiology1.40457541
80MP0000631_abnormal_neuroendocrine_gland1.34700024
81MP0005390_skeleton_phenotype1.34291933
82MP0009379_abnormal_foot_pigmentation1.33058335
83MP0000343_altered_response_to1.32771267
84MP0001845_abnormal_inflammatory_respons1.32369617
85MP0001819_abnormal_immune_cell1.28056738
86MP0002420_abnormal_adaptive_immunity1.27729915
87MP0002653_abnormal_ependyma_morphology1.26443733
88MP0002928_abnormal_bile_duct1.23843487
89MP0005397_hematopoietic_system_phenotyp1.22202824
90MP0001545_abnormal_hematopoietic_system1.22202824
91MP0005164_abnormal_response_to1.20924520
92MP0002006_tumorigenesis1.19923413
93MP0001216_abnormal_epidermal_layer1.19128990
94MP0010234_abnormal_vibrissa_follicle1.18559269
95MP0006276_abnormal_autonomic_nervous1.17804453
96MP0004272_abnormal_basement_membrane1.17538091
97MP0002089_abnormal_postnatal_growth/wei1.17199524
98MP0004134_abnormal_chest_morphology1.16737479
99MP0004808_abnormal_hematopoietic_stem1.16505974
100MP0009250_abnormal_appendicular_skeleto1.16192207
101MP0003787_abnormal_imprinting1.16102392
102MP0005551_abnormal_eye_electrophysiolog1.16025424
103MP0009840_abnormal_foam_cell1.15565081
104MP0003936_abnormal_reproductive_system1.13525119
105MP0000249_abnormal_blood_vessel1.12736483
106MP0001765_abnormal_ion_homeostasis1.12675647
107MP0000767_abnormal_smooth_muscle1.12393186
108MP0003045_fibrosis1.11783817
109MP0003195_calcinosis1.11625897
110MP0001881_abnormal_mammary_gland1.11421790
111MP0001879_abnormal_lymphatic_vessel1.10167945
112MP0003763_abnormal_thymus_physiology1.10041574
113MP0003279_aneurysm1.09997387
114MP0009765_abnormal_xenobiotic_induced1.09343935
115MP0002277_abnormal_respiratory_mucosa1.08635414
116MP0001905_abnormal_dopamine_level1.06667257
117MP0008961_abnormal_basal_metabolism1.06484130
118MP0000230_abnormal_systemic_arterial1.06176098
119MP0009764_decreased_sensitivity_to1.05933802
120MP0006054_spinal_hemorrhage1.05808023
121MP0005670_abnormal_white_adipose1.04560378
122MP0003941_abnormal_skin_development1.04128828
123MP0005671_abnormal_response_to1.04065768
124MP0004215_abnormal_myocardial_fiber1.03953722
125MP0010368_abnormal_lymphatic_system1.03884959
126MP0008872_abnormal_physiological_respon1.03724678
127MP0004133_heterotaxia1.03691245
128MP0000733_abnormal_muscle_development1.03010150
129MP0002166_altered_tumor_susceptibility1.02883800
130MP0004883_abnormal_blood_vessel1.02713431
131MP0005623_abnormal_meninges_morphology1.02095775
132MP0005464_abnormal_platelet_physiology1.02025942
133MP0004085_abnormal_heartbeat1.00571509
134MP0006082_CNS_inflammation1.00197050
135MP0001243_abnormal_dermal_layer0.99780477
136MP0005195_abnormal_posterior_eye0.98870820
137MP0003795_abnormal_bone_structure0.98234699
138MP0009053_abnormal_anal_canal0.97579124
139MP0001970_abnormal_pain_threshold0.97171758
140MP0001873_stomach_inflammation0.96160427
141MP0005508_abnormal_skeleton_morphology0.95532277
142MP0002163_abnormal_gland_morphology0.95485248
143MP0003638_abnormal_response/metabolism_0.95421713
144MP0000627_abnormal_mammary_gland0.94677504
145MP0002210_abnormal_sex_determination0.94205641
146MP0003075_altered_response_to0.94028582
147MP0002733_abnormal_thermal_nociception0.93860042
148MP0003866_abnormal_defecation0.93601296
149MP0006072_abnormal_retinal_apoptosis0.93083928
150MP0001191_abnormal_skin_condition0.92646807
151MP0005503_abnormal_tendon_morphology0.88668324
152MP0001968_abnormal_touch/_nociception0.88492299
153MP0005167_abnormal_blood-brain_barrier0.88211860
154MP0000716_abnormal_immune_system0.87821928
155MP0001145_abnormal_male_reproductive0.86434516
156MP0001986_abnormal_taste_sensitivity0.86429683
157MP0009333_abnormal_splenocyte_physiolog0.85970817
158MP0003186_abnormal_redox_activity0.85368738
159MP0004782_abnormal_surfactant_physiolog0.85261039
160MP0002064_seizures0.85109431
161MP0001764_abnormal_homeostasis0.84630063
162MP0002896_abnormal_bone_mineralization0.84246956
163MP0000026_abnormal_inner_ear0.84091737
164MP0000639_abnormal_adrenal_gland0.83719370
165MP0002102_abnormal_ear_morphology0.83538811
166MP0002398_abnormal_bone_marrow0.82716834
167MP0005165_increased_susceptibility_to0.80434307
168MP0002752_abnormal_somatic_nervous0.80005833
169MP0008469_abnormal_protein_level0.79474878
170MP0002796_impaired_skin_barrier0.79188722
171MP0001663_abnormal_digestive_system0.78828251
172MP0000653_abnormal_sex_gland0.78023615
173MP0002295_abnormal_pulmonary_circulatio0.77713750
174MP0000750_abnormal_muscle_regeneration0.77231594
175MP0010307_abnormal_tumor_latency0.77005444
176MP0004742_abnormal_vestibular_system0.75947573
177MP0002735_abnormal_chemical_nociception0.74676184
178MP0009046_muscle_twitch0.74005033
179MP0000778_abnormal_nervous_system0.71667559
180MP0001501_abnormal_sleep_pattern0.71073000
181MP0001963_abnormal_hearing_physiology0.70958914
182MP0002184_abnormal_innervation0.69617991
183MP0002572_abnormal_emotion/affect_behav0.69317485
184MP0005253_abnormal_eye_physiology0.68800574
185MP0003567_abnormal_fetal_cardiomyocyte0.68301227
186MP0003718_maternal_effect0.67621943
187MP0002063_abnormal_learning/memory/cond0.67385542
188MP0002557_abnormal_social/conspecific_i0.66439544
189MP0001486_abnormal_startle_reflex0.66358172
190MP0003950_abnormal_plasma_membrane0.66337090

Predicted human phenotypes

RankGene SetZ-score
1Stenosis of the external auditory canal (HP:0000402)4.90537365
2Osteomalacia (HP:0002749)4.87941931
3Orchitis (HP:0100796)4.45690471
4Retrobulbar optic neuritis (HP:0100654)4.19029428
5Optic neuritis (HP:0100653)4.19029428
6Persistence of primary teeth (HP:0006335)4.06652112
7Eczematoid dermatitis (HP:0000976)4.03264189
8True hermaphroditism (HP:0010459)4.02219613
9Increased density of long bones (HP:0006392)4.02115937
10Anomalous pulmonary venous return (HP:0010772)3.97460965
11Myositis (HP:0100614)3.81021406
12Mesangial abnormality (HP:0001966)3.56236633
13Abnormality of the pulmonary veins (HP:0011718)3.55551711
14Interstitial pulmonary disease (HP:0006530)3.54387361
15Periauricular skin pits (HP:0100277)3.52386674
16Preauricular pit (HP:0004467)3.52386674
17Abnormality of cells of the erythroid lineage (HP:0012130)3.51772406
18Male pseudohermaphroditism (HP:0000037)3.49483099
19Premature rupture of membranes (HP:0001788)3.47405864
20Gonadal dysgenesis (HP:0000133)3.44001066
21Oligodontia (HP:0000677)3.34408322
22Stomatitis (HP:0010280)3.30228694
23Nephronophthisis (HP:0000090)3.27328577
24Elevated erythrocyte sedimentation rate (HP:0003565)3.25678469
253-Methylglutaconic aciduria (HP:0003535)3.24537293
26Abnormality of renal resorption (HP:0011038)3.24397013
27Myocardial infarction (HP:0001658)3.12520419
28Abnormality of the renal collecting system (HP:0004742)3.09846419
29Abnormality of midbrain morphology (HP:0002418)3.08629244
30Molar tooth sign on MRI (HP:0002419)3.08629244
31Congenital, generalized hypertrichosis (HP:0004540)3.06261830
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.04573251
33Degeneration of the lateral corticospinal tracts (HP:0002314)3.04573251
34Tetraparesis (HP:0002273)3.02961217
35Protrusio acetabuli (HP:0003179)3.01539905
36Decreased circulating renin level (HP:0003351)2.96774544
37Atrophic scars (HP:0001075)2.93330904
38Hypoplastic left heart (HP:0004383)2.88748449
39Short femoral neck (HP:0100864)2.88321886
40Peritonitis (HP:0002586)2.87200770
41Chronic hepatic failure (HP:0100626)2.85518422
42Keratoconjunctivitis sicca (HP:0001097)2.83541532
43Cerebral aneurysm (HP:0004944)2.83363696
44Hypoplasia of the uterus (HP:0000013)2.82116486
45Aortic aneurysm (HP:0004942)2.81728194
46Hypoplastic pelvis (HP:0008839)2.80996664
47Paralysis (HP:0003470)2.77111245
48Abnormality of the frontal sinuses (HP:0002687)2.76614434
49Abnormality of the renal medulla (HP:0100957)2.75893375
50Asplenia (HP:0001746)2.73184529
51Vertebral compression fractures (HP:0002953)2.69125009
52Vascular calcification (HP:0004934)2.68637391
53Small hand (HP:0200055)2.68152437
54Abnormal number of erythroid precursors (HP:0012131)2.67324242
55Hydroxyprolinuria (HP:0003080)2.66275079
56Abnormality of proline metabolism (HP:0010907)2.66275079
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.65222983
58Lip pit (HP:0100267)2.65024860
59Osteolytic defects of the hand bones (HP:0009699)2.64721058
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.64721058
61Pulmonary infiltrates (HP:0002113)2.64711027
62Milia (HP:0001056)2.64497237
63Pancreatic cysts (HP:0001737)2.64209124
64Arterial thrombosis (HP:0004420)2.60663575
65Keratoconjunctivitis (HP:0001096)2.60508571
66Abolished electroretinogram (ERG) (HP:0000550)2.56652900
67Testicular neoplasm (HP:0010788)2.52077515
68Abnormality of the corticospinal tract (HP:0002492)2.51567445
69Abnormality of the nasal septum (HP:0000419)2.50779298
70Genetic anticipation (HP:0003743)2.49942198
71Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.49777398
72Aortic dissection (HP:0002647)2.46832910
73Mediastinal lymphadenopathy (HP:0100721)2.46511470
74Abnormality of the proximal phalanges of the hand (HP:0009834)2.46226779
75Clumsiness (HP:0002312)2.45207976
76Acute necrotizing encephalopathy (HP:0006965)2.42771778
77Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42487438
78Thick nail (HP:0001805)2.41449127
79Recurrent abscess formation (HP:0002722)2.38814848
80Skin pits (HP:0100276)2.37783707
81Methylmalonic acidemia (HP:0002912)2.37241002
82Pancreatic fibrosis (HP:0100732)2.34730745
83Hematochezia (HP:0002573)2.31149571
84Abnormality of the distal phalanges of the toes (HP:0010182)2.30724657
85Aplasia/hypoplasia of the uterus (HP:0008684)2.27801127
86Short nail (HP:0001799)2.26885593
87Cardiovascular calcification (HP:0011915)2.26312629
88Vasculitis (HP:0002633)2.25788846
89Autoimmune thrombocytopenia (HP:0001973)2.25688356
90Pallor (HP:0000980)2.25453636
91Fibular aplasia (HP:0002990)2.24998512
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24640523
93Esophageal varix (HP:0002040)2.24160150
94Dilatation of the ascending aorta (HP:0005111)2.23225415
95Shallow orbits (HP:0000586)2.23046632
96Hypoplastic heart (HP:0001961)2.22705406
97Recurrent gram-negative bacterial infections (HP:0005420)2.22586270
98Hypoplasia of dental enamel (HP:0006297)2.22398344
99Mitral valve prolapse (HP:0001634)2.18814431
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.18783988
101Premature loss of primary teeth (HP:0006323)2.18758405
102Macrocytic anemia (HP:0001972)2.18371084
103Progressive cerebellar ataxia (HP:0002073)2.18290949
104Recurrent bacterial skin infections (HP:0005406)2.16500423
105Abnormal mitochondria in muscle tissue (HP:0008316)2.15649467
106Abnormality of the phalanges of the 5th finger (HP:0004213)2.15112612
107Bone pain (HP:0002653)2.15051849
108Abnormal sex determination (HP:0012244)2.14992870
109Sex reversal (HP:0012245)2.14992870
110Patent foramen ovale (HP:0001655)2.14991395
111Hypoplasia of the ulna (HP:0003022)2.14385294
112Abnormality of cochlea (HP:0000375)2.14358395
113Abnormality of the pericardium (HP:0001697)2.13438880
114Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12822553
115Recurrent fungal infections (HP:0002841)2.11856187
116Abnormality of macrophages (HP:0004311)2.11428258
117Mitochondrial inheritance (HP:0001427)2.11296961
118Abnormality of the renal cortex (HP:0011035)2.09600513
119Thin bony cortex (HP:0002753)2.07832936
120Tubular atrophy (HP:0000092)2.07677978
121Vascular tortuosity (HP:0004948)2.07283657
122Distal lower limb amyotrophy (HP:0008944)2.07196402
123Axonal loss (HP:0003447)2.06929959
124Fragile skin (HP:0001030)2.06645364
125Distal lower limb muscle weakness (HP:0009053)2.05863625
126Increased connective tissue (HP:0009025)2.05293051
127Rectal prolapse (HP:0002035)2.05269867
128Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.05174210
129Arterial tortuosity (HP:0005116)2.04542906
130Right ventricular cardiomyopathy (HP:0011663)2.03979578
131Morphological abnormality of the middle ear (HP:0008609)2.03763735
132Pendular nystagmus (HP:0012043)2.03203287
133Aneurysm (HP:0002617)2.02323776
134Acute encephalopathy (HP:0006846)2.02285803
135Gingivitis (HP:0000230)2.01551586
136Metabolic alkalosis (HP:0200114)2.00949157
137Absent thumb (HP:0009777)2.00494557
138Renal Fanconi syndrome (HP:0001994)1.99791990
139Cervical subluxation (HP:0003308)1.99552765
140Congenital stationary night blindness (HP:0007642)1.99027681
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.98054525
142Abnormal rod and cone electroretinograms (HP:0008323)1.97710568
143Short tibia (HP:0005736)1.94785209
144Hyperphosphatemia (HP:0002905)1.94200917
145Cellulitis (HP:0100658)1.92173997
146Leukocytosis (HP:0001974)1.91723198
147Hemoptysis (HP:0002105)1.91222565
148Subacute progressive viral hepatitis (HP:0006572)1.90821238
149Hyperthyroidism (HP:0000836)1.90615533
150Progressive macrocephaly (HP:0004481)1.90387029
151Abnormality of DNA repair (HP:0003254)1.90315570
152Increased IgE level (HP:0003212)1.88627097
153Septo-optic dysplasia (HP:0100842)1.88124723
154Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87570352
155Tachypnea (HP:0002789)1.87463699
156Rickets (HP:0002748)1.87407083
157Abnormality of renal excretion (HP:0011036)1.86768796
158Aplasia/Hypoplasia of the ulna (HP:0006495)1.85016944
159Abnormality of the middle phalanges of the toes (HP:0010183)1.83593374
160Confusion (HP:0001289)1.83475281
161Genu recurvatum (HP:0002816)1.82662071
162Increased CSF lactate (HP:0002490)1.82316663
163Pustule (HP:0200039)1.82119851
164Increased mean platelet volume (HP:0011877)1.81843514
165Aplasia/Hypoplasia of the fibula (HP:0006492)1.78546577
166Alopecia of scalp (HP:0002293)1.78155049
167Spondylolisthesis (HP:0003302)1.77889782
168Methylmalonic aciduria (HP:0012120)1.77816878
169Aplasia/hypoplasia of the femur (HP:0005613)1.77340571
170Plantar hyperkeratosis (HP:0007556)1.76378884
171Goiter (HP:0000853)1.76151303
172Osteomyelitis (HP:0002754)1.76040389
173Medial flaring of the eyebrow (HP:0010747)1.75109144
174Menorrhagia (HP:0000132)1.74556166
175Camptodactyly of toe (HP:0001836)1.73587590
176Onycholysis (HP:0001806)1.73244525
177Fused cervical vertebrae (HP:0002949)1.72241179
178Emphysema (HP:0002097)1.71223259
179Abnormal platelet volume (HP:0011876)1.70258394
180Xerostomia (HP:0000217)1.69422099
181Periodontitis (HP:0000704)1.69151609
182Micronodular cirrhosis (HP:0001413)1.68109041
183Syringomyelia (HP:0003396)1.66132130
184Spinal cord lesions (HP:0100561)1.66132130
185Ulnar bowing (HP:0003031)1.63948637
186Prostate neoplasm (HP:0100787)1.62200916
187Upper limb muscle weakness (HP:0003484)1.61631580
188Broad metatarsal (HP:0001783)1.61159739
189Gangrene (HP:0100758)1.60410381
190Abnormal platelet function (HP:0011869)1.58494252
191Impaired platelet aggregation (HP:0003540)1.58494252
192Anorexia (HP:0002039)1.57770987
193Abnormality of primary teeth (HP:0006481)1.57494765
194Abnormality of the gastric mucosa (HP:0004295)1.57107573
195Aseptic necrosis (HP:0010885)1.56477282
196Segmental peripheral demyelination/remyelination (HP:0003481)1.56150032
197Stomach cancer (HP:0012126)1.55943704
198Striae distensae (HP:0001065)1.55907662
199Tibial bowing (HP:0002982)1.55856556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.58695208
2TLK13.36617993
3IRAK33.18809824
4EPHA22.93743156
5ACVR1B2.82109748
6ADRBK22.72029285
7TBK12.69696264
8FRK2.64138729
9MAPK152.59252090
10BMPR1B2.58691381
11EPHB12.49471400
12GRK12.42392507
13MAP3K32.36475426
14EPHA32.31941707
15IKBKB2.31896995
16ARAF2.28055607
17STK162.25867970
18RPS6KA22.24909729
19WNK42.23030560
20CHUK2.09705258
21ERN12.09157224
22RPS6KL12.06112534
23RPS6KC12.06112534
24SGK22.05702587
25TAOK32.01842520
26TXK1.96173412
27MAP3K101.93985350
28RPS6KA41.92744748
29MAP4K11.88840114
30RIPK11.87071231
31TGFBR21.83913113
32MST41.80338010
33GRK71.75710378
34IKBKE1.70850417
35PIM21.67608210
36SGK2231.66307299
37SGK4941.66307299
38BRAF1.65775417
39BMX1.65433724
40FGFR41.61937209
41MAP3K91.55958520
42STK101.53336351
43TRIB31.51077154
44JAK31.49433909
45JAK11.48821983
46LATS11.45607049
47PINK11.36755939
48PIM11.35045952
49MAP2K31.34922605
50TTN1.34810107
51PTK61.31607711
52FGFR31.27283401
53AKT31.26856381
54STK391.21485264
55TYK21.20411173
56CDK121.19560301
57SGK31.17743064
58NLK1.17519383
59ITK1.16662374
60DMPK1.14049452
61INSRR1.12419343
62ZAK1.11080107
63PDGFRB1.10784145
64GSK3A1.09033923
65SGK11.08582419
66PLK41.06928723
67TEC1.05284801
68PAK31.04040823
69ADRBK11.03567414
70MYLK1.03193261
71SIK21.03043091
72MAP3K121.02341563
73MATK0.99230112
74ZAP700.97172963
75LRRK20.96676154
76CSK0.96643149
77SIK10.95885253
78AURKA0.95098360
79PKN20.94702339
80MAP2K20.94376781
81MST1R0.91919862
82PTK20.89423811
83PDGFRA0.88857373
84TIE10.88006887
85CDK60.87835000
86MAP3K40.87773575
87TGFBR10.85680060
88MAPKAPK20.84213766
89PRKACA0.84194411
90EEF2K0.84180221
91PAK20.84160646
92PHKG10.83524039
93PHKG20.83524039
94MAP3K10.83261565
95HCK0.82188227
96NEK90.82053483
97TSSK60.82036730
98BLK0.81839259
99PKN10.81699563
100MAP3K110.81023268
101STK30.79929200
102FER0.77394410
103HIPK20.76903200
104DYRK20.76626481
105VRK10.75401245
106MAP3K20.75175082
107JAK20.75149090
108RPS6KB20.72816933
109NTRK30.72293297
110RPS6KA50.72035154
111TAOK10.71658396
112PRKCG0.69299422
113CASK0.69260320
114STK38L0.69230677
115ERBB40.68416188
116TRPM70.68324276
117ALK0.68160556
118DYRK30.67903583
119PNCK0.66738836
120PDK20.66185223
121OXSR10.65559825
122WNK10.63763000
123PLK20.62830177
124BTK0.62538403
125PRKCI0.62529997
126DDR20.62071929
127PRKD20.61263429
128RPS6KA10.61228664
129MAP2K70.59195584
130EPHB20.58480434
131IRAK40.58451774
132MARK30.58326732
133MAPKAPK30.58254240
134MTOR0.57709873
135MUSK0.56996897
136MAPK40.56995636
137MARK20.56434802
138IRAK10.56224000
139PRKG20.55663864
140ABL20.55436714
141PRKACG0.55267648
142MELK0.54993013
143MOS0.54540171
144PAK40.53906895
145ABL10.53585957
146MET0.52561258
147CDK90.52069533
148DYRK1B0.51773154
149TAOK20.51121882
150CDC70.50621281
151NUAK10.50310326
152INSR0.49588253
153ERBB20.48671151
154CSNK1G20.47865825
155STK240.47450587
156TNK20.46270805
157EGFR0.46051425
158LCK0.45808936
159KDR0.45709801
160DYRK1A0.43791840
161MAP2K40.43654699
162PRKCE0.43632770
163RPS6KA60.43490534
164PRKCA0.43338127
165KIT0.43196563
166CAMKK20.43174394
167RPS6KA30.42627124
168CDK190.42158698
169GRK50.41680446
170STK110.41102928
171SIK30.40460351
172MAPK130.40048095
173MAPKAPK50.39674353
174CDK80.38828871
175IGF1R0.35507752
176PRKCQ0.34416101
177DAPK20.33458075

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.92243940
2Oxidative phosphorylation_Homo sapiens_hsa001903.88431917
3Osteoclast differentiation_Homo sapiens_hsa043802.77465079
4Parkinsons disease_Homo sapiens_hsa050122.77110208
5Protein export_Homo sapiens_hsa030602.72612245
6Leishmaniasis_Homo sapiens_hsa051402.72111181
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.67732708
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63870052
9TNF signaling pathway_Homo sapiens_hsa046682.52478626
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.30483988
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.25217961
12Legionellosis_Homo sapiens_hsa051342.24016810
13Malaria_Homo sapiens_hsa051442.21173295
14Alzheimers disease_Homo sapiens_hsa050102.19723625
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16450361
16Chemical carcinogenesis_Homo sapiens_hsa052042.15066202
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.04234918
18Toxoplasmosis_Homo sapiens_hsa051451.94139755
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92994080
20Huntingtons disease_Homo sapiens_hsa050161.90707451
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89182708
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87627425
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85605755
24Homologous recombination_Homo sapiens_hsa034401.81846061
25Cardiac muscle contraction_Homo sapiens_hsa042601.81470478
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80911640
27Nucleotide excision repair_Homo sapiens_hsa034201.77220406
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75906376
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73577374
30Mineral absorption_Homo sapiens_hsa049781.68941857
31Graft-versus-host disease_Homo sapiens_hsa053321.67151202
32Retinol metabolism_Homo sapiens_hsa008301.67146893
33Vitamin digestion and absorption_Homo sapiens_hsa049771.66670080
34Apoptosis_Homo sapiens_hsa042101.65760872
35Small cell lung cancer_Homo sapiens_hsa052221.59116380
36Phototransduction_Homo sapiens_hsa047441.57362523
37Pertussis_Homo sapiens_hsa051331.53337206
38Rheumatoid arthritis_Homo sapiens_hsa053231.52594199
39Measles_Homo sapiens_hsa051621.52114451
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.51011039
41Amoebiasis_Homo sapiens_hsa051461.47668400
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.45408652
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43961633
44Chronic myeloid leukemia_Homo sapiens_hsa052201.43430955
45Collecting duct acid secretion_Homo sapiens_hsa049661.43052509
46Hematopoietic cell lineage_Homo sapiens_hsa046401.41510878
47Nicotine addiction_Homo sapiens_hsa050331.41320352
48B cell receptor signaling pathway_Homo sapiens_hsa046621.40048435
49ECM-receptor interaction_Homo sapiens_hsa045121.39325833
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37253570
51African trypanosomiasis_Homo sapiens_hsa051431.36008630
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.35403856
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34706346
54Salmonella infection_Homo sapiens_hsa051321.33942637
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32900948
56Staphylococcus aureus infection_Homo sapiens_hsa051501.30581916
57Acute myeloid leukemia_Homo sapiens_hsa052211.29482553
58Linoleic acid metabolism_Homo sapiens_hsa005911.28369458
59Influenza A_Homo sapiens_hsa051641.28195180
60Tuberculosis_Homo sapiens_hsa051521.27592845
61T cell receptor signaling pathway_Homo sapiens_hsa046601.27196114
62Antigen processing and presentation_Homo sapiens_hsa046121.25332032
63Hepatitis B_Homo sapiens_hsa051611.24705584
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23637403
65Prolactin signaling pathway_Homo sapiens_hsa049171.23251375
66Proteoglycans in cancer_Homo sapiens_hsa052051.23060861
67Shigellosis_Homo sapiens_hsa051311.21668615
68Basal transcription factors_Homo sapiens_hsa030221.21398384
69Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19568858
70Focal adhesion_Homo sapiens_hsa045101.19042088
71Bladder cancer_Homo sapiens_hsa052191.18972713
72Allograft rejection_Homo sapiens_hsa053301.18896016
73Adipocytokine signaling pathway_Homo sapiens_hsa049201.17554844
74Morphine addiction_Homo sapiens_hsa050321.17253447
75Sulfur metabolism_Homo sapiens_hsa009201.16665292
76MicroRNAs in cancer_Homo sapiens_hsa052061.12872346
77Adherens junction_Homo sapiens_hsa045201.11336184
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11101620
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08440059
80Circadian rhythm_Homo sapiens_hsa047101.07651619
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06406036
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03838237
83Cholinergic synapse_Homo sapiens_hsa047251.02490203
84Melanoma_Homo sapiens_hsa052181.00561116
85HTLV-I infection_Homo sapiens_hsa051661.00532876
86Pancreatic cancer_Homo sapiens_hsa052121.00409574
87RNA polymerase_Homo sapiens_hsa030201.00177476
88Herpes simplex infection_Homo sapiens_hsa051680.99531445
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97985601
90Serotonergic synapse_Homo sapiens_hsa047260.96599364
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96341094
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.95966392
93Hepatitis C_Homo sapiens_hsa051600.95028562
94Type I diabetes mellitus_Homo sapiens_hsa049400.94748353
95Insulin resistance_Homo sapiens_hsa049310.93817685
96Glutamatergic synapse_Homo sapiens_hsa047240.93564694
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92982376
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.88869730
99Tryptophan metabolism_Homo sapiens_hsa003800.88377801
100p53 signaling pathway_Homo sapiens_hsa041150.88008889
101Viral myocarditis_Homo sapiens_hsa054160.86955356
102Asthma_Homo sapiens_hsa053100.86453398
103FoxO signaling pathway_Homo sapiens_hsa040680.85329658
104TGF-beta signaling pathway_Homo sapiens_hsa043500.84335245
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84273837
106Arachidonic acid metabolism_Homo sapiens_hsa005900.84129438
107Fanconi anemia pathway_Homo sapiens_hsa034600.84107603
108Circadian entrainment_Homo sapiens_hsa047130.83593471
109Regulation of autophagy_Homo sapiens_hsa041400.82681602
110Phagosome_Homo sapiens_hsa041450.80466141
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80156126
112Chemokine signaling pathway_Homo sapiens_hsa040620.79368458
113Prostate cancer_Homo sapiens_hsa052150.79332160
114Dorso-ventral axis formation_Homo sapiens_hsa043200.78954168
115RNA degradation_Homo sapiens_hsa030180.77568823
116Viral carcinogenesis_Homo sapiens_hsa052030.77178381
117Platelet activation_Homo sapiens_hsa046110.76389731
118Caffeine metabolism_Homo sapiens_hsa002320.75620207
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75383215
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74650784
121MAPK signaling pathway_Homo sapiens_hsa040100.73772323
122HIF-1 signaling pathway_Homo sapiens_hsa040660.72579180
123Prion diseases_Homo sapiens_hsa050200.71474308
124Type II diabetes mellitus_Homo sapiens_hsa049300.70488693
125VEGF signaling pathway_Homo sapiens_hsa043700.69071274
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68334382
127Renal cell carcinoma_Homo sapiens_hsa052110.67225345
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65713053
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.65555345
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64979904
131Systemic lupus erythematosus_Homo sapiens_hsa053220.64912617
132Notch signaling pathway_Homo sapiens_hsa043300.64894256
133Pathways in cancer_Homo sapiens_hsa052000.64212890
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64004991
135Epstein-Barr virus infection_Homo sapiens_hsa051690.62738535
136Ovarian steroidogenesis_Homo sapiens_hsa049130.62207666
137Lysosome_Homo sapiens_hsa041420.59854117
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59487825
139Cocaine addiction_Homo sapiens_hsa050300.58768669
140Oxytocin signaling pathway_Homo sapiens_hsa049210.58673306
141Hedgehog signaling pathway_Homo sapiens_hsa043400.58670668
142Colorectal cancer_Homo sapiens_hsa052100.57631207
143Gastric acid secretion_Homo sapiens_hsa049710.57110637
144Hippo signaling pathway_Homo sapiens_hsa043900.56855961
145Renin secretion_Homo sapiens_hsa049240.55496651
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55401464
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55141278
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54397231
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51822254
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.51087651
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50684611
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49775586
153Complement and coagulation cascades_Homo sapiens_hsa046100.48979404
154Rap1 signaling pathway_Homo sapiens_hsa040150.46991004
155Mismatch repair_Homo sapiens_hsa034300.46954100
156GABAergic synapse_Homo sapiens_hsa047270.46686917
157Insulin secretion_Homo sapiens_hsa049110.46354939
158Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45506751
159Olfactory transduction_Homo sapiens_hsa047400.44764570
160Endocytosis_Homo sapiens_hsa041440.42474674
161cAMP signaling pathway_Homo sapiens_hsa040240.39674159
162Dopaminergic synapse_Homo sapiens_hsa047280.39497319
163Primary immunodeficiency_Homo sapiens_hsa053400.39453333
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.37524184
165Dilated cardiomyopathy_Homo sapiens_hsa054140.37313350
166Starch and sucrose metabolism_Homo sapiens_hsa005000.35966716
167Calcium signaling pathway_Homo sapiens_hsa040200.33848314
168Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33597753
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33220737
170Peroxisome_Homo sapiens_hsa041460.32764665
171Metabolic pathways_Homo sapiens_hsa011000.32461598
172Ras signaling pathway_Homo sapiens_hsa040140.32071385
173Glycerolipid metabolism_Homo sapiens_hsa005610.31642103
174Basal cell carcinoma_Homo sapiens_hsa052170.29900856
175Folate biosynthesis_Homo sapiens_hsa007900.29175486
176Axon guidance_Homo sapiens_hsa043600.28284602
177Taste transduction_Homo sapiens_hsa047420.28040867
178Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28031643
179Pyrimidine metabolism_Homo sapiens_hsa002400.26054960
180Glutathione metabolism_Homo sapiens_hsa004800.25997668
181Ether lipid metabolism_Homo sapiens_hsa005650.25607320

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