MAD2L1BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.79834564
2purine nucleobase biosynthetic process (GO:0009113)5.72069290
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.36221081
4regulation of spindle organization (GO:0090224)5.27201161
5metaphase plate congression (GO:0051310)5.25263473
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.06721445
7DNA replication checkpoint (GO:0000076)5.02310161
8nucleobase biosynthetic process (GO:0046112)4.95018496
9ribosome biogenesis (GO:0042254)4.73994877
10termination of RNA polymerase III transcription (GO:0006386)4.66018459
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.66018459
12regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.59745222
13rRNA modification (GO:0000154)4.59545910
14negative regulation of ligase activity (GO:0051352)4.58430352
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.58430352
16protein localization to kinetochore (GO:0034501)4.55306270
17vitamin transmembrane transport (GO:0035461)4.51814728
18ribosome assembly (GO:0042255)4.40464076
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.35465809
20protein neddylation (GO:0045116)4.34326833
21establishment of chromosome localization (GO:0051303)4.33557108
22chaperone-mediated protein transport (GO:0072321)4.30180773
23energy coupled proton transport, down electrochemical gradient (GO:0015985)4.29126055
24ATP synthesis coupled proton transport (GO:0015986)4.29126055
25regulation of cellular amino acid metabolic process (GO:0006521)4.28263145
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.24977651
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.24977651
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.24977651
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.24431807
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.24431807
317-methylguanosine mRNA capping (GO:0006370)4.24215521
32regulation of mitotic spindle organization (GO:0060236)4.18975764
337-methylguanosine RNA capping (GO:0009452)4.18691591
34RNA capping (GO:0036260)4.18691591
35maturation of 5.8S rRNA (GO:0000460)4.17303457
36protein localization to chromosome, centromeric region (GO:0071459)4.16291145
37positive regulation of chromosome segregation (GO:0051984)4.15436185
38signal transduction involved in DNA integrity checkpoint (GO:0072401)4.12258760
39signal transduction involved in DNA damage checkpoint (GO:0072422)4.12258760
40signal transduction involved in cell cycle checkpoint (GO:0072395)4.08848335
41cullin deneddylation (GO:0010388)4.07053423
42establishment of protein localization to mitochondrial membrane (GO:0090151)4.06130263
43termination of RNA polymerase I transcription (GO:0006363)3.99123628
44protein deneddylation (GO:0000338)3.98738592
45folic acid metabolic process (GO:0046655)3.98401625
46transcription from RNA polymerase I promoter (GO:0006360)3.91598536
47transcription elongation from RNA polymerase I promoter (GO:0006362)3.85263593
48CENP-A containing nucleosome assembly (GO:0034080)3.84012165
49establishment of integrated proviral latency (GO:0075713)3.80895503
50DNA deamination (GO:0045006)3.80664441
51rRNA methylation (GO:0031167)3.76893783
52respiratory electron transport chain (GO:0022904)3.76528840
53attachment of spindle microtubules to kinetochore (GO:0008608)3.74460074
54protein K6-linked ubiquitination (GO:0085020)3.73109623
55regulation of ubiquitin-protein transferase activity (GO:0051438)3.70635408
56transcription elongation from RNA polymerase II promoter (GO:0006368)3.69804641
57electron transport chain (GO:0022900)3.68677878
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67372019
59monoubiquitinated protein deubiquitination (GO:0035520)3.66412732
60meiosis I (GO:0007127)3.64733663
61spindle checkpoint (GO:0031577)3.63892532
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.61656331
63ribonucleoprotein complex biogenesis (GO:0022613)3.61561738
64regulation of ligase activity (GO:0051340)3.58490345
65DNA-templated transcription, elongation (GO:0006354)3.58125023
66regulation of chromosome segregation (GO:0051983)3.58034554
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57963178
68transcription initiation from RNA polymerase I promoter (GO:0006361)3.57459564
69protein targeting to mitochondrion (GO:0006626)3.57149434
70establishment of viral latency (GO:0019043)3.56343224
71chromatin remodeling at centromere (GO:0031055)3.53792870
72folic acid transport (GO:0015884)3.53173287
73proteasome assembly (GO:0043248)3.52294503
74histone exchange (GO:0043486)3.51704771
75DNA replication-independent nucleosome assembly (GO:0006336)3.51286730
76DNA replication-independent nucleosome organization (GO:0034724)3.51286730
77mitotic sister chromatid segregation (GO:0000070)3.46614499
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45667062
79microtubule depolymerization (GO:0007019)3.41469762
80mitotic nuclear envelope disassembly (GO:0007077)3.41436598
81kinetochore assembly (GO:0051382)3.41077459
82blastocyst development (GO:0001824)3.41054142
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40597864
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39550492
85negative regulation of protein ubiquitination (GO:0031397)3.38291058
86rRNA processing (GO:0006364)3.37648750
87DNA replication initiation (GO:0006270)3.36364212
88inner cell mass cell proliferation (GO:0001833)3.35997351
89respiratory chain complex IV assembly (GO:0008535)3.34779370
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32914778
91protein localization to chromosome (GO:0034502)3.31627918
92protein localization to mitochondrion (GO:0070585)3.31515087
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30369695
94establishment of protein localization to mitochondrion (GO:0072655)3.30092675
95DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.30074524
96rRNA metabolic process (GO:0016072)3.29707723
97spliceosomal snRNP assembly (GO:0000387)3.28404354
98protein complex biogenesis (GO:0070271)3.28085199
99positive regulation of viral transcription (GO:0050434)3.26632789
100positive regulation of cell cycle arrest (GO:0071158)3.26106163
101mitochondrial respiratory chain complex assembly (GO:0033108)3.25023065
102tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24953265
103RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24953265
104telomere maintenance via semi-conservative replication (GO:0032201)3.24061091
105regulation of cellular amine metabolic process (GO:0033238)3.22856631
106regulation of transcription from RNA polymerase I promoter (GO:0006356)3.22211649
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21481344
108regulation of double-strand break repair via homologous recombination (GO:0010569)3.21027297
109mitotic chromosome condensation (GO:0007076)3.20376896
110negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.19596840
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19393043
112maturation of SSU-rRNA (GO:0030490)3.19300041
113mitotic spindle checkpoint (GO:0071174)3.17625661
114DNA strand elongation involved in DNA replication (GO:0006271)3.16352133
115regulation of mitochondrial translation (GO:0070129)3.15451549
116DNA damage response, signal transduction resulting in transcription (GO:0042772)3.15147631
117nuclear envelope disassembly (GO:0051081)3.15008926
118membrane disassembly (GO:0030397)3.15008926
119negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.13710233
120regulation of translation in response to stress (GO:0043555)3.13575720
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13401691
122mitochondrial respiratory chain complex I assembly (GO:0032981)3.13401691
123NADH dehydrogenase complex assembly (GO:0010257)3.13401691
124oocyte maturation (GO:0001556)3.13275346
125DNA catabolic process, exonucleolytic (GO:0000738)3.12812247
126formation of translation preinitiation complex (GO:0001731)3.11947381
127regulation of mitotic spindle checkpoint (GO:1903504)3.11348534
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11348534
129DNA strand elongation (GO:0022616)3.10173965
130regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10058730
131meiotic chromosome segregation (GO:0045132)3.09898349
132chromosome segregation (GO:0007059)3.09138493
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09071855
134male meiosis I (GO:0007141)3.07501785
135negative regulation of chromosome segregation (GO:0051985)3.07161519
136kinetochore organization (GO:0051383)3.04922282
137negative regulation of mitotic sister chromatid separation (GO:2000816)3.04619018
138negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04619018
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04619018
140negative regulation of sister chromatid segregation (GO:0033046)3.04619018
141DNA-dependent DNA replication (GO:0006261)3.04548647
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04431946
143transcription-coupled nucleotide-excision repair (GO:0006283)3.04315365
144positive regulation of ligase activity (GO:0051351)3.04222633
145transcription from mitochondrial promoter (GO:0006390)3.01328840
146pseudouridine synthesis (GO:0001522)2.98589575
147cytochrome complex assembly (GO:0017004)2.97505241
148negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97497288
149mitotic spindle assembly checkpoint (GO:0007094)2.97167959
150DNA damage response, detection of DNA damage (GO:0042769)2.96187047
151transcription from RNA polymerase III promoter (GO:0006383)2.95922184
152spindle assembly checkpoint (GO:0071173)2.95542349
153G1/S transition of mitotic cell cycle (GO:0000082)2.94726280
154cell cycle G1/S phase transition (GO:0044843)2.94726280
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91965112
156protein-cofactor linkage (GO:0018065)2.90933423
157signal transduction in response to DNA damage (GO:0042770)2.90889154
158L-methionine salvage (GO:0071267)2.90207984
159L-methionine biosynthetic process (GO:0071265)2.90207984
160amino acid salvage (GO:0043102)2.90207984
161sequestering of actin monomers (GO:0042989)2.87620544
162histone mRNA metabolic process (GO:0008334)2.86798719
163peptidyl-histidine modification (GO:0018202)2.85170611
164IMP biosynthetic process (GO:0006188)2.78442650
165mitochondrial RNA metabolic process (GO:0000959)2.77991391
166regulation of retinoic acid receptor signaling pathway (GO:0048385)2.77742565
167dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.77381061
168inner mitochondrial membrane organization (GO:0007007)2.76852272
169DNA double-strand break processing (GO:0000729)2.74297022
170negative regulation of cell cycle G1/S phase transition (GO:1902807)2.73981386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76377300
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.96460030
3* FOXM1_23109430_ChIP-Seq_U2OS_Human4.25612680
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67995066
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43737142
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.37868047
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37761583
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.34064472
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26286520
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.21244498
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14011682
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.10408521
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81233960
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66684518
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60597795
16VDR_23849224_ChIP-Seq_CD4+_Human2.56716532
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51662178
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46211521
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41252380
20AR_21909140_ChIP-Seq_LNCAP_Human2.41216698
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17845950
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17712965
23XRN2_22483619_ChIP-Seq_HELA_Human2.16629327
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11241638
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98306955
26GABP_19822575_ChIP-Seq_HepG2_Human1.96788158
27FOXP3_21729870_ChIP-Seq_TREG_Human1.91150010
28DCP1A_22483619_ChIP-Seq_HELA_Human1.89912939
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89667157
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87083190
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.86760891
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83644306
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74982077
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72223998
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71924738
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.69892956
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66401354
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65185021
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63523842
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.61848117
41* SRF_21415370_ChIP-Seq_HL-1_Mouse1.61428821
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60756304
43ELK1_19687146_ChIP-ChIP_HELA_Human1.53671463
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.53571961
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50188979
46TTF2_22483619_ChIP-Seq_HELA_Human1.48933879
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48035991
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43457017
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42470169
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41746806
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41228215
52* KDM5A_27292631_Chip-Seq_BREAST_Human1.40824469
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39265121
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.39051668
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38447983
56ZNF263_19887448_ChIP-Seq_K562_Human1.36513048
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33965591
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32296899
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29560048
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28591740
61CIITA_25753668_ChIP-Seq_RAJI_Human1.17630575
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17522575
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17246360
64* ELK1_22589737_ChIP-Seq_MCF10A_Human1.13710959
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12082085
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10119459
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09999344
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09516412
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08938619
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08650472
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08044745
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06922363
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06744773
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06543701
75* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06292940
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04425698
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04203530
78SPI1_23547873_ChIP-Seq_NB4_Human1.02961102
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02706415
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02342892
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00832819
82EGR1_19374776_ChIP-ChIP_THP-1_Human0.97553993
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97266689
84ZNF274_21170338_ChIP-Seq_K562_Hela0.95877823
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.92750541
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92223318
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91995572
88MYC_18940864_ChIP-ChIP_HL60_Human0.90052985
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.88135686
90* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87824234
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87560962
92TFEB_21752829_ChIP-Seq_HELA_Human0.86734834
93* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86286797
94* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85124799
95IRF8_21731497_ChIP-ChIP_J774_Mouse0.84953822
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84504914
97* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81270228
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80900832
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.80592054
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79483399
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.78917280
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77738996
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77230373
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76862909
105* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75963931
106* MYC_22102868_ChIP-Seq_BL_Human0.75749259
107KAP1_27257070_Chip-Seq_ESCs_Mouse0.75154801
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74952914
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73778450
110ELF5_23300383_ChIP-Seq_T47D_Human0.72587303
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72166221
112MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71551229
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71107104
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70917259
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70787027
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68860531
117IRF1_19129219_ChIP-ChIP_H3396_Human0.68607864
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67261774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.61253553
2MP0003111_abnormal_nucleus_morphology4.71434243
3MP0000372_irregular_coat_pigmentation4.36248377
4MP0003718_maternal_effect4.04220568
5MP0004957_abnormal_blastocyst_morpholog3.96724054
6MP0003077_abnormal_cell_cycle3.93441026
7MP0003806_abnormal_nucleotide_metabolis3.78367214
8MP0010094_abnormal_chromosome_stability3.71948029
9MP0008007_abnormal_cellular_replicative3.14811143
10MP0008057_abnormal_DNA_replication3.13763924
11MP0008058_abnormal_DNA_repair2.88672483
12MP0005451_abnormal_body_composition2.54137198
13MP0006035_abnormal_mitochondrial_morpho2.43809223
14MP0008260_abnormal_autophagy2.32165151
15MP0002396_abnormal_hematopoietic_system2.28522063
16MP0009333_abnormal_splenocyte_physiolog2.28466400
17MP0003123_paternal_imprinting2.28044057
18MP0008789_abnormal_olfactory_epithelium2.26546648
19MP0001730_embryonic_growth_arrest2.15002229
20MP0008932_abnormal_embryonic_tissue2.11930825
21MP0010307_abnormal_tumor_latency2.08628275
22MP0009697_abnormal_copulation2.04599695
23MP0008877_abnormal_DNA_methylation2.02171034
24MP0005075_abnormal_melanosome_morpholog1.96932513
25MP0003786_premature_aging1.96162965
26MP0000350_abnormal_cell_proliferation1.95377851
27MP0001529_abnormal_vocalization1.89074976
28MP0005397_hematopoietic_system_phenotyp1.83120964
29MP0001545_abnormal_hematopoietic_system1.83120964
30MP0005394_taste/olfaction_phenotype1.83027199
31MP0005499_abnormal_olfactory_system1.83027199
32MP0003646_muscle_fatigue1.81096101
33MP0009840_abnormal_foam_cell1.74441619
34MP0003656_abnormal_erythrocyte_physiolo1.72449389
35MP0006292_abnormal_olfactory_placode1.64126147
36MP0001672_abnormal_embryogenesis/_devel1.60349878
37MP0005380_embryogenesis_phenotype1.60349878
38MP0002102_abnormal_ear_morphology1.49641227
39MP0002210_abnormal_sex_determination1.46104279
40MP0002148_abnormal_hypersensitivity_rea1.44363813
41MP0003221_abnormal_cardiomyocyte_apopto1.41405915
42MP0005395_other_phenotype1.38691446
43MP0003984_embryonic_growth_retardation1.38514291
44MP0001697_abnormal_embryo_size1.38057577
45MP0001929_abnormal_gametogenesis1.34544985
46MP0002088_abnormal_embryonic_growth/wei1.32586849
47MP0005671_abnormal_response_to1.31479938
48MP0002080_prenatal_lethality1.31424772
49MP0001661_extended_life_span1.30715055
50MP0005377_hearing/vestibular/ear_phenot1.29148299
51MP0003878_abnormal_ear_physiology1.29148299
52MP0002090_abnormal_vision1.26477818
53MP0002019_abnormal_tumor_incidence1.24147453
54MP0000313_abnormal_cell_death1.22029663
55MP0001119_abnormal_female_reproductive1.21602740
56MP0000653_abnormal_sex_gland1.20443871
57MP0001145_abnormal_male_reproductive1.19867143
58MP0000516_abnormal_urinary_system1.19605338
59MP0005367_renal/urinary_system_phenotyp1.19605338
60MP0002095_abnormal_skin_pigmentation1.19376289
61MP0001293_anophthalmia1.18481390
62MP0003011_delayed_dark_adaptation1.17388547
63MP0004808_abnormal_hematopoietic_stem1.17065525
64MP0003315_abnormal_perineum_morphology1.17033843
65MP0000015_abnormal_ear_pigmentation1.16595826
66MP0001853_heart_inflammation1.15613692
67MP0002132_abnormal_respiratory_system1.13839715
68MP0001324_abnormal_eye_pigmentation1.13621464
69MP0002938_white_spotting1.12240487
70MP0000490_abnormal_crypts_of1.12074692
71MP0000689_abnormal_spleen_morphology1.11293113
72MP0002398_abnormal_bone_marrow1.09205853
73MP0001542_abnormal_bone_strength1.08288066
74MP0002722_abnormal_immune_system1.07917999
75MP0005408_hypopigmentation1.05940667
76MP0000343_altered_response_to1.05863418
77MP0002085_abnormal_embryonic_tissue1.05684777
78MP0003136_yellow_coat_color1.02619518
79MP0003699_abnormal_female_reproductive1.02216287
80MP0003941_abnormal_skin_development1.02081449
81MP0005084_abnormal_gallbladder_morpholo1.01528310
82MP0002086_abnormal_extraembryonic_tissu1.01447703
83MP0005310_abnormal_salivary_gland1.01270000
84MP0005621_abnormal_cell_physiology1.00078137
85MP0009764_decreased_sensitivity_to0.98606638
86MP0000647_abnormal_sebaceous_gland0.97607674
87MP0000750_abnormal_muscle_regeneration0.94290976
88MP0005410_abnormal_fertilization0.91864524
89MP0005464_abnormal_platelet_physiology0.90318989
90MP0003938_abnormal_ear_development0.89339835
91MP0003763_abnormal_thymus_physiology0.88436989
92MP0002429_abnormal_blood_cell0.85982525
93MP0000716_abnormal_immune_system0.85411843
94MP0005384_cellular_phenotype0.85121750
95MP0000358_abnormal_cell_content/0.84254736
96MP0003186_abnormal_redox_activity0.84084436
97MP0003828_pulmonary_edema0.83751085
98MP0002163_abnormal_gland_morphology0.83729805
99MP0003567_abnormal_fetal_cardiomyocyte0.83683525
100MP0002084_abnormal_developmental_patter0.82519293
101MP0008995_early_reproductive_senescence0.82324332
102MP0002736_abnormal_nociception_after0.81886325
103MP0000703_abnormal_thymus_morphology0.81779852
104MP0005266_abnormal_metabolism0.79954196
105MP0005197_abnormal_uvea_morphology0.78934492
106MP0000627_abnormal_mammary_gland0.78789896
107MP0004147_increased_porphyrin_level0.78067601
108MP0009765_abnormal_xenobiotic_induced0.77858453
109MP0002277_abnormal_respiratory_mucosa0.77503526
110MP0006082_CNS_inflammation0.76878305
111MP0002452_abnormal_antigen_presenting0.76151139
112MP0001919_abnormal_reproductive_system0.76105326
113MP0001835_abnormal_antigen_presentation0.75909438
114MP0002653_abnormal_ependyma_morphology0.74736690
115MP0001800_abnormal_humoral_immune0.74600625
116MP0001764_abnormal_homeostasis0.74147499
117MP0002420_abnormal_adaptive_immunity0.71812653
118MP0001819_abnormal_immune_cell0.71494282
119MP0005253_abnormal_eye_physiology0.71274248
120MP0000858_altered_metastatic_potential0.70786176
121MP0002723_abnormal_immune_serum0.69531379
122MP0008873_increased_physiological_sensi0.68628279
123MP0002161_abnormal_fertility/fecundity0.68045972
124MP0002160_abnormal_reproductive_system0.67979846
125MP0000371_diluted_coat_color0.67838987
126MP0005076_abnormal_cell_differentiation0.67546125
127MP0002837_dystrophic_cardiac_calcinosis0.66399623
128MP0005058_abnormal_lysosome_morphology0.65667061
129MP0005083_abnormal_biliary_tract0.65527217
130MP0009046_muscle_twitch0.65450594
131MP0003195_calcinosis0.65288029
132MP0005389_reproductive_system_phenotype0.64620940
133MP0006036_abnormal_mitochondrial_physio0.64492949
134MP0010030_abnormal_orbit_morphology0.64440643
135MP0003937_abnormal_limbs/digits/tail_de0.63633763
136MP0005187_abnormal_penis_morphology0.62839008
137MP0003448_altered_tumor_morphology0.62775568
138MP0009763_increased_sensitivity_to0.62762000
139MP0009672_abnormal_birth_weight0.61948275
140MP0005332_abnormal_amino_acid0.61055184
141MP0002751_abnormal_autonomic_nervous0.59984237
142MP0003698_abnormal_male_reproductive0.59253821
143MP0001905_abnormal_dopamine_level0.59121537
144MP0005319_abnormal_enzyme/_coenzyme0.59094214
145MP0008469_abnormal_protein_level0.58077809
146MP0009785_altered_susceptibility_to0.57196868
147MP0002405_respiratory_system_inflammati0.56137500
148MP0001727_abnormal_embryo_implantation0.55386612
149MP0005000_abnormal_immune_tolerance0.54175699
150MP0009278_abnormal_bone_marrow0.53660393

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.45846859
2Breast hypoplasia (HP:0003187)5.46270237
3Acute necrotizing encephalopathy (HP:0006965)4.94866629
4Carpal bone hypoplasia (HP:0001498)4.86577708
5Abnormal mitochondria in muscle tissue (HP:0008316)4.69973944
6Acute encephalopathy (HP:0006846)4.50805556
7Mitochondrial inheritance (HP:0001427)4.38063316
8Patellar aplasia (HP:0006443)4.31341092
9Increased CSF lactate (HP:0002490)4.28691290
10Aplasia/Hypoplasia of the patella (HP:0006498)4.16615748
11Impulsivity (HP:0100710)4.11415117
12Progressive macrocephaly (HP:0004481)3.95115980
13Hepatocellular necrosis (HP:0001404)3.88811283
14Cerebral hypomyelination (HP:0006808)3.82050380
15Increased hepatocellular lipid droplets (HP:0006565)3.81813486
16Rough bone trabeculation (HP:0100670)3.76138880
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75598757
18Hepatic necrosis (HP:0002605)3.75290568
19Hyperglycinemia (HP:0002154)3.72646722
20Renal Fanconi syndrome (HP:0001994)3.59907123
21Entropion (HP:0000621)3.54355024
22Chromsome breakage (HP:0040012)3.49139356
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.45816102
24Abnormal protein N-linked glycosylation (HP:0012347)3.45816102
25Abnormal protein glycosylation (HP:0012346)3.45816102
26Abnormal glycosylation (HP:0012345)3.45816102
27Type I transferrin isoform profile (HP:0003642)3.42302461
28Lipid accumulation in hepatocytes (HP:0006561)3.42098520
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.33176804
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.30079509
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.30079509
32Multiple enchondromatosis (HP:0005701)3.29950811
33Cerebral edema (HP:0002181)3.25443588
34Increased serum lactate (HP:0002151)3.18457258
35Abnormality of the preputium (HP:0100587)3.17819612
36Meckel diverticulum (HP:0002245)3.16066794
37Facial hemangioma (HP:0000329)3.15996169
38Abnormality of glycolysis (HP:0004366)3.15434693
39Increased serum pyruvate (HP:0003542)3.13915422
40Irregular epiphyses (HP:0010582)3.12524268
413-Methylglutaconic aciduria (HP:0003535)3.11773714
42Increased intramyocellular lipid droplets (HP:0012240)3.10113471
43Capillary hemangiomas (HP:0005306)3.09321947
44Abnormal spermatogenesis (HP:0008669)3.09042055
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02452278
46Secondary amenorrhea (HP:0000869)3.01720659
47Lactic acidosis (HP:0003128)3.01080622
48Pustule (HP:0200039)3.00745904
49Hyperglycinuria (HP:0003108)2.93757879
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.93488464
51Oral leukoplakia (HP:0002745)2.92596695
52Gout (HP:0001997)2.92111053
53Abnormality of the ileum (HP:0001549)2.88408136
54Reduced antithrombin III activity (HP:0001976)2.88003123
55Abnormal trabecular bone morphology (HP:0100671)2.79082355
56Microvesicular hepatic steatosis (HP:0001414)2.76840493
57Exercise intolerance (HP:0003546)2.76546864
58Flat capital femoral epiphysis (HP:0003370)2.75488666
59Abnormality of chromosome stability (HP:0003220)2.74081046
60Microretrognathia (HP:0000308)2.73585454
61Azoospermia (HP:0000027)2.71579180
62Respiratory failure (HP:0002878)2.71347727
63Abnormality of the labia minora (HP:0012880)2.65197494
64Nausea (HP:0002018)2.64015928
65CNS hypomyelination (HP:0003429)2.61051527
66Methylmalonic aciduria (HP:0012120)2.60388042
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.58866404
68Cholecystitis (HP:0001082)2.58157419
69Abnormal gallbladder physiology (HP:0012438)2.58157419
70Respiratory difficulties (HP:0002880)2.57659071
71Male infertility (HP:0003251)2.56839869
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.55266452
73Exertional dyspnea (HP:0002875)2.55243322
74Premature ovarian failure (HP:0008209)2.55012391
75Absent radius (HP:0003974)2.54014748
76Areflexia of lower limbs (HP:0002522)2.52995504
77Breast aplasia (HP:0100783)2.52961317
78Bone marrow hypocellularity (HP:0005528)2.51854494
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50799206
80Type 2 muscle fiber atrophy (HP:0003554)2.48590193
81Generalized aminoaciduria (HP:0002909)2.48275599
82Progressive muscle weakness (HP:0003323)2.46586855
83Increased muscle lipid content (HP:0009058)2.45001671
84Muscle fiber atrophy (HP:0100295)2.44780162
85Prostate neoplasm (HP:0100787)2.44739866
86Ureteral duplication (HP:0000073)2.44003086
87Atrioventricular block (HP:0001678)2.42701764
88Aplastic anemia (HP:0001915)2.40274585
89Aplasia/Hypoplasia of the breasts (HP:0010311)2.39161395
90Methylmalonic acidemia (HP:0002912)2.37526769
91Pancytopenia (HP:0001876)2.37044225
92Reticulocytopenia (HP:0001896)2.36236630
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35832638
94Absent epiphyses (HP:0010577)2.35832638
95Death in infancy (HP:0001522)2.34499566
96Optic disc pallor (HP:0000543)2.33352476
97Absent forearm bone (HP:0003953)2.33004022
98Aplasia involving forearm bones (HP:0009822)2.33004022
99Myelodysplasia (HP:0002863)2.32044966
100CNS demyelination (HP:0007305)2.29623442
101Pancreatic fibrosis (HP:0100732)2.25845490
102Abnormality of methionine metabolism (HP:0010901)2.24526581
103Hyperalaninemia (HP:0003348)2.23620094
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23620094
105Abnormality of alanine metabolism (HP:0010916)2.23620094
106Abnormality of renal resorption (HP:0011038)2.22741675
107Stillbirth (HP:0003826)2.22567385
108Sparse eyelashes (HP:0000653)2.21007166
109Lethargy (HP:0001254)2.20470157
110Duodenal stenosis (HP:0100867)2.19695470
111Small intestinal stenosis (HP:0012848)2.19695470
112Small epiphyses (HP:0010585)2.18936192
113Abnormality of the anterior horn cell (HP:0006802)2.18025413
114Degeneration of anterior horn cells (HP:0002398)2.18025413
115Leukodystrophy (HP:0002415)2.16956758
116IgG deficiency (HP:0004315)2.15396874
117Horseshoe kidney (HP:0000085)2.11726683
118Abnormality of serine family amino acid metabolism (HP:0010894)2.10937811
119Abnormality of glycine metabolism (HP:0010895)2.10937811
120Tetraplegia (HP:0002445)2.10103185
121Cleft eyelid (HP:0000625)2.07877048
122Sparse lateral eyebrow (HP:0005338)2.06979632
123Postnatal microcephaly (HP:0005484)2.04123768
124Petechiae (HP:0000967)2.03536533
125Oligodactyly (HP:0012165)2.03293153
126Mutism (HP:0002300)2.02662211
127Short thumb (HP:0009778)2.01404760
128Abnormality of the umbilical cord (HP:0010881)2.01372468
129Oligodactyly (hands) (HP:0001180)1.99402630
130Emotional lability (HP:0000712)1.99081013
131X-linked dominant inheritance (HP:0001423)1.98035499
132Poor head control (HP:0002421)1.97843935
133Delusions (HP:0000746)1.96149390
134Slender long bone (HP:0003100)1.94187904
135Premature graying of hair (HP:0002216)1.91583275
136Adrenal hypoplasia (HP:0000835)1.90771336
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.89800469
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89452418
139Cellular immunodeficiency (HP:0005374)1.89440450
140Abnormal lung lobation (HP:0002101)1.88484057
141Abnormality of serum amino acid levels (HP:0003112)1.88288490
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88251594
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.88164373
144Acute myeloid leukemia (HP:0004808)1.87691519
145Tracheoesophageal fistula (HP:0002575)1.85663398
146Squamous cell carcinoma (HP:0002860)1.85294595
147Clubbing of toes (HP:0100760)1.83497676
148Reduced subcutaneous adipose tissue (HP:0003758)1.83485498
149Hypoplastic pelvis (HP:0008839)1.83152559
150Trismus (HP:0000211)1.82779966
151Absent thumb (HP:0009777)1.82427050
152Upper limb muscle weakness (HP:0003484)1.81756666
153Congenital, generalized hypertrichosis (HP:0004540)1.81558637
154Hypoplasia of the fovea (HP:0007750)1.81035712
155Aplasia/Hypoplasia of the fovea (HP:0008060)1.81035712
156Abnormality of cells of the erythroid lineage (HP:0012130)1.79634861
157Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78867837
158Neoplasm of the pancreas (HP:0002894)1.78861255
159Muscle fiber splitting (HP:0003555)1.77252638
160Abnormal number of erythroid precursors (HP:0012131)1.76409827
161Macrocytic anemia (HP:0001972)1.76031940
162Amniotic constriction ring (HP:0009775)1.75500208
163Abnormality of placental membranes (HP:0011409)1.75500208
164Prominent nose (HP:0000448)1.75328228
165Abnormality of the epiphysis of the femoral head (HP:0010574)1.74392595
166Personality changes (HP:0000751)1.74381578
167Polycythemia (HP:0001901)1.74234683
168Dicarboxylic aciduria (HP:0003215)1.73888948
169Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73888948
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.73851103
171Abnormality of the fovea (HP:0000493)1.71573436
172Glycosuria (HP:0003076)1.69105907
173Abnormality of urine glucose concentration (HP:0011016)1.69105907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.79676442
2WEE14.20512517
3BRSK23.40637701
4VRK23.35538067
5PLK43.30685663
6EIF2AK13.21523514
7SRPK13.04099340
8TRIM282.95770584
9NEK22.91452104
10NME22.80677165
11PBK2.80469872
12LATS22.30687871
13IRAK32.24623152
14ACVR1B2.18751064
15PLK12.12455556
16BRSK12.10987944
17PLK31.96528861
18TTK1.95749437
19CDC71.93320430
20EIF2AK31.84521157
21DYRK31.84175372
22MKNK21.74540067
23BCKDK1.74176824
24STK38L1.70646760
25MAP3K121.66305595
26MUSK1.59888309
27TESK21.58475346
28AURKB1.57921642
29ARAF1.57530296
30VRK11.53677537
31AKT31.51712786
32CCNB11.49637110
33RPS6KA41.47146049
34STK31.45316241
35MAP2K71.39840163
36CHEK21.36907566
37BRAF1.33912081
38ZAK1.33159273
39TSSK61.31602241
40STK161.28818722
41TAOK11.22999443
42MKNK11.19857211
43MAP4K21.16483750
44PIM21.15250109
45ADRBK21.11843799
46RAF11.11292943
47DAPK11.09474786
48NEK11.09092827
49AURKA1.09033775
50MARK31.01330306
51STK240.96847081
52MAP3K80.96676195
53CDK70.96651131
54WNK30.95608994
55PIM10.93527111
56CDK40.89396717
57CHEK10.85403613
58BMPR1B0.85046728
59DYRK20.84513438
60STK40.82261457
61PAK40.81934496
62LIMK10.81837418
63ABL20.81237329
64ERBB30.80984067
65MAP2K30.79570983
66MELK0.78127671
67CDK30.77555101
68MAP4K10.77126155
69BCR0.76702076
70TESK10.76701664
71PAK10.76452989
72EIF2AK20.75580499
73PLK20.73715709
74PINK10.72806334
75PDK20.71202219
76CSNK1G20.71047905
77SIK30.70159608
78STK100.70003598
79EPHA20.69745502
80PRKCI0.69708153
81CSNK1A1L0.67223687
82NUAK10.66239254
83CDK80.64846638
84ILK0.64215376
85ATR0.62725100
86GRK70.62591709
87MAP3K60.62081997
88BMPR20.61831858
89DAPK30.61570202
90MAP3K30.61337413
91ZAP700.60942794
92LATS10.59583235
93MAP3K110.58633534
94MATK0.55551835
95MAP3K50.54059523
96TAOK20.52527233
97CDK20.52284349
98GRK10.51792116
99KDR0.49197936
100PDK30.48782620
101PDK40.48782620
102IKBKB0.44740627
103RPS6KB20.44537826
104CSNK2A10.43490079
105ATM0.43470787
106TLK10.42801489
107ERBB40.41619226
108PRKAA10.41362530
109MYLK0.38862406
110MAPKAPK30.38576911
111TXK0.37878850
112CDK10.37105173
113KSR20.36790036
114JAK30.35986233
115NEK60.35769891
116TAOK30.35458796
117TYK20.34835801
118TBK10.33354025
119IRAK40.32397129
120MAP3K40.32373905
121NEK90.31842095
122CSNK1G30.30432528
123CSNK2A20.30407600
124PASK0.30268092
125GRK50.30209918
126EEF2K0.30170648
127RPS6KA50.30000233
128CDK140.29739968
129CDK190.28999356
130FER0.27293995
131PRKCG0.26094295
132TEC0.25468499
133CSNK1G10.23510686
134MOS0.22740885
135NME10.21108686
136MST40.19858269

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.55343321
2RNA polymerase_Homo sapiens_hsa030205.34190417
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29473359
4Oxidative phosphorylation_Homo sapiens_hsa001903.44882043
5Proteasome_Homo sapiens_hsa030503.20400375
6Parkinsons disease_Homo sapiens_hsa050123.09042331
7RNA transport_Homo sapiens_hsa030133.06208623
8Cell cycle_Homo sapiens_hsa041103.05834148
9Basal transcription factors_Homo sapiens_hsa030222.85255769
10Pyrimidine metabolism_Homo sapiens_hsa002402.73210936
11DNA replication_Homo sapiens_hsa030302.72060126
12Homologous recombination_Homo sapiens_hsa034402.47873958
13Spliceosome_Homo sapiens_hsa030402.39727360
14Ribosome_Homo sapiens_hsa030102.11493350
15p53 signaling pathway_Homo sapiens_hsa041152.10788182
16Mismatch repair_Homo sapiens_hsa034302.09858036
17Nucleotide excision repair_Homo sapiens_hsa034202.07962965
18Fanconi anemia pathway_Homo sapiens_hsa034602.06414654
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97114083
20Fatty acid elongation_Homo sapiens_hsa000621.90902878
21Base excision repair_Homo sapiens_hsa034101.87896939
22Folate biosynthesis_Homo sapiens_hsa007901.84409215
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84190860
24Pentose phosphate pathway_Homo sapiens_hsa000301.83375094
25Alzheimers disease_Homo sapiens_hsa050101.80425288
26Purine metabolism_Homo sapiens_hsa002301.75595386
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73182744
28RNA degradation_Homo sapiens_hsa030181.67787886
29Regulation of autophagy_Homo sapiens_hsa041401.65622678
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50667939
31Sulfur relay system_Homo sapiens_hsa041221.44300813
32Epstein-Barr virus infection_Homo sapiens_hsa051691.41993965
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38515631
34Vitamin digestion and absorption_Homo sapiens_hsa049771.32432252
35Sulfur metabolism_Homo sapiens_hsa009201.24765387
36mRNA surveillance pathway_Homo sapiens_hsa030151.23245110
37Oocyte meiosis_Homo sapiens_hsa041141.22034315
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19286310
39Steroid biosynthesis_Homo sapiens_hsa001001.17252006
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15625899
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10010079
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.09809831
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.08584829
44Collecting duct acid secretion_Homo sapiens_hsa049661.07062501
45Pyruvate metabolism_Homo sapiens_hsa006201.06557571
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.05982626
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05817838
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.02400934
49Propanoate metabolism_Homo sapiens_hsa006400.99830212
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98237238
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93996928
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92539993
53Herpes simplex infection_Homo sapiens_hsa051680.89028034
54Biosynthesis of amino acids_Homo sapiens_hsa012300.87624522
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83447276
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81661034
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79678519
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75920135
59Non-homologous end-joining_Homo sapiens_hsa034500.74970399
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74160708
61Antigen processing and presentation_Homo sapiens_hsa046120.74160408
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70834226
63One carbon pool by folate_Homo sapiens_hsa006700.69339624
64Cardiac muscle contraction_Homo sapiens_hsa042600.65662503
65Primary immunodeficiency_Homo sapiens_hsa053400.63998220
66Peroxisome_Homo sapiens_hsa041460.63117856
67N-Glycan biosynthesis_Homo sapiens_hsa005100.61114824
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.60934503
69Butanoate metabolism_Homo sapiens_hsa006500.58938045
70Viral carcinogenesis_Homo sapiens_hsa052030.57194867
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56829325
72Caffeine metabolism_Homo sapiens_hsa002320.56509660
73Circadian rhythm_Homo sapiens_hsa047100.55493738
74Protein export_Homo sapiens_hsa030600.54500731
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52021449
76Vibrio cholerae infection_Homo sapiens_hsa051100.50626960
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48125507
78Glutathione metabolism_Homo sapiens_hsa004800.48038420
79Huntingtons disease_Homo sapiens_hsa050160.47567236
80Arachidonic acid metabolism_Homo sapiens_hsa005900.43591007
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42659174
82FoxO signaling pathway_Homo sapiens_hsa040680.42254577
83Measles_Homo sapiens_hsa051620.42048319
84Linoleic acid metabolism_Homo sapiens_hsa005910.41701497
85Apoptosis_Homo sapiens_hsa042100.40550230
86Sphingolipid metabolism_Homo sapiens_hsa006000.40104194
87Metabolic pathways_Homo sapiens_hsa011000.39466099
88Hepatitis B_Homo sapiens_hsa051610.35983015
89Influenza A_Homo sapiens_hsa051640.35781775
90Fatty acid metabolism_Homo sapiens_hsa012120.35714293
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.35553275
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35480399
93HTLV-I infection_Homo sapiens_hsa051660.33945473
94Small cell lung cancer_Homo sapiens_hsa052220.33148600
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31447124
96Fructose and mannose metabolism_Homo sapiens_hsa000510.31235738
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30851170
98Arginine and proline metabolism_Homo sapiens_hsa003300.30010456
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28476089
100Shigellosis_Homo sapiens_hsa051310.27569000
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27465127
102Tyrosine metabolism_Homo sapiens_hsa003500.26866817
103MicroRNAs in cancer_Homo sapiens_hsa052060.26639592
104Chemical carcinogenesis_Homo sapiens_hsa052040.26582187
105Rheumatoid arthritis_Homo sapiens_hsa053230.26144542
106Carbon metabolism_Homo sapiens_hsa012000.26098128
107TGF-beta signaling pathway_Homo sapiens_hsa043500.26089495
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.24601054
109Allograft rejection_Homo sapiens_hsa053300.24150046
110Hematopoietic cell lineage_Homo sapiens_hsa046400.23717173
111Selenocompound metabolism_Homo sapiens_hsa004500.23456435
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23097932
113Legionellosis_Homo sapiens_hsa051340.22788116
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.22035382
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21786308
116beta-Alanine metabolism_Homo sapiens_hsa004100.21385183
117Tryptophan metabolism_Homo sapiens_hsa003800.21064152
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20675730
119Autoimmune thyroid disease_Homo sapiens_hsa053200.15540503
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15523285
121Thyroid cancer_Homo sapiens_hsa052160.15416437
122Systemic lupus erythematosus_Homo sapiens_hsa053220.15123284
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14952482
124Galactose metabolism_Homo sapiens_hsa000520.14809920
125Graft-versus-host disease_Homo sapiens_hsa053320.14088526
126Ether lipid metabolism_Homo sapiens_hsa005650.13799142
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11831299
128Lysosome_Homo sapiens_hsa041420.11669213
129HIF-1 signaling pathway_Homo sapiens_hsa040660.10771334
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10474768
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09226171
132Leishmaniasis_Homo sapiens_hsa051400.08299651
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07549803
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06322716
135Pancreatic cancer_Homo sapiens_hsa052120.06162040
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06111175
137Renal cell carcinoma_Homo sapiens_hsa052110.05305832
138Asthma_Homo sapiens_hsa053100.05105331

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