MAB21L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may play a role in a variety of psychiatric disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell development (GO:0042461)9.34889747
2eye photoreceptor cell development (GO:0042462)8.97359809
3photoreceptor cell maintenance (GO:0045494)8.15250510
4retinal rod cell development (GO:0046548)7.97280529
5detection of light stimulus involved in sensory perception (GO:0050962)7.13398036
6detection of light stimulus involved in visual perception (GO:0050908)7.13398036
7phototransduction (GO:0007602)6.96586512
8GMP metabolic process (GO:0046037)6.95741257
9detection of light stimulus (GO:0009583)6.68818760
10phototransduction, visible light (GO:0007603)6.67641776
11positive regulation of guanylate cyclase activity (GO:0031284)6.54807190
12detection of visible light (GO:0009584)6.50829217
13visual perception (GO:0007601)6.05043992
14sensory perception of light stimulus (GO:0050953)5.97124864
15regulation of guanylate cyclase activity (GO:0031282)5.89452095
16photoreceptor cell differentiation (GO:0046530)5.54246727
17eye photoreceptor cell differentiation (GO:0001754)5.54246727
18retina development in camera-type eye (GO:0060041)5.49937561
19cellular response to light stimulus (GO:0071482)4.78255076
20detection of external stimulus (GO:0009581)4.76713218
21protein-chromophore linkage (GO:0018298)4.73061349
22sequestering of actin monomers (GO:0042989)4.71637878
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.68396904
24detection of abiotic stimulus (GO:0009582)4.67312676
25postsynaptic membrane organization (GO:0001941)4.61345164
26auditory behavior (GO:0031223)4.54621837
27regulation of cGMP metabolic process (GO:0030823)4.53877876
28protein localization to synapse (GO:0035418)4.45745674
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.42427481
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.39648583
31presynaptic membrane organization (GO:0097090)4.23452822
32presynaptic membrane assembly (GO:0097105)4.15113424
33cell migration involved in heart development (GO:0060973)4.04000021
34response to pheromone (GO:0019236)3.98896960
35regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97253481
36axon extension (GO:0048675)3.89873303
37retinal ganglion cell axon guidance (GO:0031290)3.87132381
38negative regulation of axon guidance (GO:1902668)3.85611496
39positive regulation of cGMP biosynthetic process (GO:0030828)3.85376949
40protein localization to cilium (GO:0061512)3.84947153
41nonmotile primary cilium assembly (GO:0035058)3.83867982
42neurotransmitter-gated ion channel clustering (GO:0072578)3.79396149
43positive regulation of synapse assembly (GO:0051965)3.77659056
44peripheral nervous system neuron development (GO:0048935)3.76999665
45retina layer formation (GO:0010842)3.70344140
46positive regulation of cGMP metabolic process (GO:0030825)3.70075395
47mechanosensory behavior (GO:0007638)3.68072485
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.65926905
49axon extension involved in axon guidance (GO:0048846)3.65926905
50dendritic spine morphogenesis (GO:0060997)3.63116793
51regulation of cGMP biosynthetic process (GO:0030826)3.60406071
52behavioral response to ethanol (GO:0048149)3.51859929
53neuron development (GO:0048666)3.50374971
54pyrimidine nucleobase catabolic process (GO:0006208)3.50248991
55synaptic vesicle maturation (GO:0016188)3.50102914
56regulation of axon guidance (GO:1902667)3.48661430
57receptor guanylyl cyclase signaling pathway (GO:0007168)3.47983075
58central nervous system neuron axonogenesis (GO:0021955)3.46529039
59negative regulation of transcription regulatory region DNA binding (GO:2000678)3.42374751
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.39242727
61dopaminergic neuron differentiation (GO:0071542)3.37314544
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31162609
63cranial nerve morphogenesis (GO:0021602)3.29207630
64regulation of respiratory gaseous exchange (GO:0043576)3.28610578
65regulation of voltage-gated calcium channel activity (GO:1901385)3.28203082
66regulation of feeding behavior (GO:0060259)3.24714805
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24321129
68embryonic forelimb morphogenesis (GO:0035115)3.23861511
69sensory perception (GO:0007600)3.18419982
70behavioral response to nicotine (GO:0035095)3.17519764
71regulation of respiratory system process (GO:0044065)3.17040412
72regulation of axon extension involved in axon guidance (GO:0048841)3.15913493
73neuron projection extension (GO:1990138)3.13405884
74peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.13190243
75cardiac ventricle formation (GO:0003211)3.12145836
76synaptic vesicle exocytosis (GO:0016079)3.11936729
77negative regulation of axon extension (GO:0030517)3.09289029
78cellular response to radiation (GO:0071478)3.07599526
79regulation of secondary heart field cardioblast proliferation (GO:0003266)3.06416898
80regulation of cardioblast proliferation (GO:0003264)3.06416898
81neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.06410890
82synapse assembly (GO:0007416)3.06222922
83membrane hyperpolarization (GO:0060081)3.05945816
84response to auditory stimulus (GO:0010996)3.05277042
85regulation of clathrin-mediated endocytosis (GO:2000369)3.02656233
86cerebellar Purkinje cell differentiation (GO:0021702)3.02633877
87forelimb morphogenesis (GO:0035136)3.01863966
88neuromuscular synaptic transmission (GO:0007274)3.01649013
89regulation of synapse assembly (GO:0051963)3.00435807
90regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.99399563
91sympathetic nervous system development (GO:0048485)2.96761407
92cornea development in camera-type eye (GO:0061303)2.92348256
93cardiac chamber formation (GO:0003207)2.90950793
94neuronal ion channel clustering (GO:0045161)2.90785424
95hindbrain development (GO:0030902)2.90282181
96negative chemotaxis (GO:0050919)2.88589898
97transmission of nerve impulse (GO:0019226)2.86585907
98urinary tract smooth muscle contraction (GO:0014848)2.85176946
99cell morphogenesis involved in neuron differentiation (GO:0048667)2.84637525
100enteric nervous system development (GO:0048484)2.83765286
101kidney mesenchyme development (GO:0072074)2.81598791
102layer formation in cerebral cortex (GO:0021819)2.81123316
103synaptic vesicle docking involved in exocytosis (GO:0016081)2.81044410
104regulation of transcription regulatory region DNA binding (GO:2000677)2.80185916
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79580575
106ionotropic glutamate receptor signaling pathway (GO:0035235)2.76021717
107neuron migration (GO:0001764)2.75987543
108dendrite morphogenesis (GO:0048813)2.75897485
109suckling behavior (GO:0001967)2.75028411
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74323538
111chemosensory behavior (GO:0007635)2.74296818
112mating behavior (GO:0007617)2.73436045
113regulation of synaptic vesicle exocytosis (GO:2000300)2.70738369
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70572153
115metanephric mesenchyme development (GO:0072075)2.69113820
116response to light stimulus (GO:0009416)2.68188947
117spinal cord development (GO:0021510)2.67823729
118nucleobase catabolic process (GO:0046113)2.66692448
119negative regulation of dendrite development (GO:2000171)2.66209676
120positive regulation of neurotransmitter transport (GO:0051590)2.65859399
121axonal fasciculation (GO:0007413)2.65677655
122glutamate receptor signaling pathway (GO:0007215)2.65449908
123negative regulation of receptor-mediated endocytosis (GO:0048261)2.65433238
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62594278
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62218622
126cell migration in hindbrain (GO:0021535)2.61546914
127lens morphogenesis in camera-type eye (GO:0002089)2.60706191
128regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.60407461
129regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.60407461
130regulation of neurotransmitter secretion (GO:0046928)2.59920178
131negative regulation of dendrite morphogenesis (GO:0050774)2.58998001
132synaptic transmission, cholinergic (GO:0007271)2.58753506
133head development (GO:0060322)2.58154258
134retina homeostasis (GO:0001895)2.57839728
135embryonic body morphogenesis (GO:0010172)2.57792523
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.56988560
137vocalization behavior (GO:0071625)2.56595368
138neuron maturation (GO:0042551)2.56465396
139regulation of axon extension (GO:0030516)2.56380631
140negative regulation of axonogenesis (GO:0050771)2.56366971
141neurotransmitter secretion (GO:0007269)2.55899368
142dopamine receptor signaling pathway (GO:0007212)2.55098646
143central nervous system projection neuron axonogenesis (GO:0021952)2.54570227
144short-term memory (GO:0007614)2.54245883
145adult walking behavior (GO:0007628)2.54049845
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.53858682
147cerebellar granule cell differentiation (GO:0021707)2.52792772
148positive regulation of catecholamine secretion (GO:0033605)2.52392360
149negative regulation of microtubule polymerization (GO:0031115)2.52363600
150positive regulation of gastrulation (GO:2000543)2.51920120
151cellular response to prostaglandin stimulus (GO:0071379)2.51418196
152behavioral response to cocaine (GO:0048148)2.51161607
153ganglion development (GO:0061548)2.50982952
154neuron cell-cell adhesion (GO:0007158)2.50718763
155establishment of mitochondrion localization (GO:0051654)2.49856976
156dendrite development (GO:0016358)2.49688368
157regulation of synapse structural plasticity (GO:0051823)2.48095792
158cellular potassium ion homeostasis (GO:0030007)2.47385706
159heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.46976686
160synaptic vesicle endocytosis (GO:0048488)2.46466150
161regulation of NFAT protein import into nucleus (GO:0051532)2.46195303
162neurotransmitter transport (GO:0006836)2.43662423
163axoneme assembly (GO:0035082)2.43582183
164regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43370210
165striatum development (GO:0021756)2.43143224
166positive regulation of sodium ion transmembrane transport (GO:1902307)2.42675926
167cerebellum development (GO:0021549)2.42663323
168intraspecies interaction between organisms (GO:0051703)2.41344036
169social behavior (GO:0035176)2.41344036
170neuron recognition (GO:0008038)2.41060534
171glutamate secretion (GO:0014047)2.41005844
172regulation of rhodopsin mediated signaling pathway (GO:0022400)11.9253141
173rhodopsin mediated signaling pathway (GO:0016056)11.5951740
174retinal cone cell development (GO:0046549)10.3886438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.49816342
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73570228
3* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70683403
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70683403
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.65044469
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55404402
7* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47707712
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42704329
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42207368
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39733713
11* EZH2_27294783_Chip-Seq_ESCs_Mouse2.39262217
12GBX2_23144817_ChIP-Seq_PC3_Human2.34808399
13* EED_16625203_ChIP-ChIP_MESCs_Mouse2.32286430
14* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31936027
15* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21522259
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18110319
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17519239
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16934743
19CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.10246050
20TAF15_26573619_Chip-Seq_HEK293_Human2.07898829
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06682816
22DROSHA_22980978_ChIP-Seq_HELA_Human2.05622358
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05025264
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03494391
25REST_21632747_ChIP-Seq_MESCs_Mouse2.01983899
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01665647
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98362619
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95645312
29* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94198711
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93367777
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.91415677
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80497773
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.80480191
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79108603
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.76905590
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75932333
37* RING1B_27294783_Chip-Seq_NPCs_Mouse1.75865025
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75076517
39* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71100689
40FUS_26573619_Chip-Seq_HEK293_Human1.70970910
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68002587
42IGF1R_20145208_ChIP-Seq_DFB_Human1.65407036
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.64827751
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63551747
45ZNF274_21170338_ChIP-Seq_K562_Hela1.59947666
46* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55480084
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.48839078
48KDM2B_26808549_Chip-Seq_K562_Human1.48769495
49* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47716528
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46296392
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43805984
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42706634
53RNF2_27304074_Chip-Seq_NSC_Mouse1.42464805
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.38538109
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36618789
56EWS_26573619_Chip-Seq_HEK293_Human1.33795527
57AR_19668381_ChIP-Seq_PC3_Human1.32218446
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30947249
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30006383
60VDR_22108803_ChIP-Seq_LS180_Human1.29293241
61AHR_22903824_ChIP-Seq_MCF-7_Human1.28465859
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25639574
63SMAD4_21799915_ChIP-Seq_A2780_Human1.24522066
64* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24254940
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.24107447
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24031619
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22522436
68* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22162875
69TP53_18474530_ChIP-ChIP_U2OS_Human1.21089582
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18694574
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17701225
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.15788483
73* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14706642
74AR_25329375_ChIP-Seq_VCAP_Human1.14602730
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14141436
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13263072
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.10020003
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09985559
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09554825
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09554825
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08647678
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.08165694
83* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08002884
84P300_19829295_ChIP-Seq_ESCs_Human1.07548411
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.07186463
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07183774
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07161878
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06676450
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.06192838
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05747979
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05747979
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05553079
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.05241242
94* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05146747
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03884921
96SOX9_26525672_Chip-Seq_HEART_Mouse1.03873913
97* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03017237
98CTCF_27219007_Chip-Seq_Bcells_Human1.01456326
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.01032601
100* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00500653
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00430035
102TP53_16413492_ChIP-PET_HCT116_Human1.00223678
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99503504
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98819818
105* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98764150
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98306720
107AR_21572438_ChIP-Seq_LNCaP_Human0.98019839
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97945560
109STAT3_23295773_ChIP-Seq_U87_Human0.97423892
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97341690
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96830940
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96695378
113BCAT_22108803_ChIP-Seq_LS180_Human0.96061044
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.95954056
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94629657
116RUNX2_22187159_ChIP-Seq_PCA_Human0.93993861
117* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93846239
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.93444157
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93263987
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92988016
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.92089658
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92076194
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92060211
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90546591
125* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89702358
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89573302
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89450792
128CBP_20019798_ChIP-Seq_JUKART_Human0.88335423
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88335423
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.88120119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.29758067
2MP0003011_delayed_dark_adaptation6.18225791
3MP0006072_abnormal_retinal_apoptosis5.65903657
4MP0005253_abnormal_eye_physiology5.21495418
5MP0008789_abnormal_olfactory_epithelium3.30578184
6MP0002638_abnormal_pupillary_reflex3.28300823
7MP0005423_abnormal_somatic_nervous3.21081508
8* MP0005195_abnormal_posterior_eye3.12380758
9MP0005499_abnormal_olfactory_system3.01624770
10MP0005394_taste/olfaction_phenotype3.01624770
11MP0005391_vision/eye_phenotype2.82538707
12MP0003787_abnormal_imprinting2.63723001
13* MP0001324_abnormal_eye_pigmentation2.60448520
14MP0005503_abnormal_tendon_morphology2.50431967
15MP0003950_abnormal_plasma_membrane2.25256260
16MP0002752_abnormal_somatic_nervous2.04344136
17MP0005248_abnormal_Harderian_gland2.03615642
18MP0002229_neurodegeneration2.00680053
19MP0001984_abnormal_olfaction1.99702738
20MP0002090_abnormal_vision1.97809065
21MP0004270_analgesia1.89595430
22MP0002653_abnormal_ependyma_morphology1.89044947
23MP0001529_abnormal_vocalization1.84496486
24MP0010030_abnormal_orbit_morphology1.83703259
25MP0006292_abnormal_olfactory_placode1.82288521
26MP0002882_abnormal_neuron_morphology1.79967681
27MP0004859_abnormal_synaptic_plasticity1.77982995
28MP0001346_abnormal_lacrimal_gland1.72290242
29MP0004885_abnormal_endolymph1.72088026
30MP0000778_abnormal_nervous_system1.69019535
31MP0003315_abnormal_perineum_morphology1.62535240
32MP0002734_abnormal_mechanical_nocicepti1.62031423
33MP0006276_abnormal_autonomic_nervous1.61638773
34MP0001502_abnormal_circadian_rhythm1.57576484
35MP0002184_abnormal_innervation1.56782467
36MP0003880_abnormal_central_pattern1.51388954
37MP0003635_abnormal_synaptic_transmissio1.45375733
38MP0005257_abnormal_intraocular_pressure1.39589179
39MP0009384_cardiac_valve_regurgitation1.37477142
40MP0003937_abnormal_limbs/digits/tail_de1.31525345
41MP0001486_abnormal_startle_reflex1.27615322
42MP0002272_abnormal_nervous_system1.26170774
43* MP0005197_abnormal_uvea_morphology1.25892974
44MP0003121_genomic_imprinting1.20490694
45MP0002067_abnormal_sensory_capabilities1.20166468
46MP0000538_abnormal_urinary_bladder1.18414803
47MP0002063_abnormal_learning/memory/cond1.17601353
48MP0009745_abnormal_behavioral_response1.12453888
49MP0002928_abnormal_bile_duct1.11991951
50MP0000537_abnormal_urethra_morphology1.10112545
51MP0008438_abnormal_cutaneous_collagen1.07957980
52MP0009046_muscle_twitch1.06740682
53MP0002064_seizures1.06230953
54MP0010386_abnormal_urinary_bladder1.04801429
55MP0002160_abnormal_reproductive_system1.04484607
56MP0002751_abnormal_autonomic_nervous1.03771867
57MP0001764_abnormal_homeostasis1.02959795
58MP0002572_abnormal_emotion/affect_behav1.02507861
59MP0000516_abnormal_urinary_system1.01048596
60MP0005367_renal/urinary_system_phenotyp1.01048596
61MP0003122_maternal_imprinting1.00864122
62MP0002233_abnormal_nose_morphology0.98201406
63MP0008877_abnormal_DNA_methylation0.97976747
64MP0001188_hyperpigmentation0.96965671
65MP0001986_abnormal_taste_sensitivity0.94196515
66MP0000631_abnormal_neuroendocrine_gland0.94137175
67MP0002152_abnormal_brain_morphology0.93290555
68MP0004811_abnormal_neuron_physiology0.91931921
69MP0003385_abnormal_body_wall0.91924922
70MP0008569_lethality_at_weaning0.91612692
71MP0002557_abnormal_social/conspecific_i0.90890358
72MP0001968_abnormal_touch/_nociception0.90786817
73MP0003283_abnormal_digestive_organ0.90772556
74MP0003567_abnormal_fetal_cardiomyocyte0.88561228
75* MP0001286_abnormal_eye_development0.87348029
76MP0001542_abnormal_bone_strength0.86832981
77MP0003861_abnormal_nervous_system0.86583025
78MP0001919_abnormal_reproductive_system0.85629411
79MP0003119_abnormal_digestive_system0.85466296
80MP0005389_reproductive_system_phenotype0.85329619
81MP0002108_abnormal_muscle_morphology0.84938089
82MP0003634_abnormal_glial_cell0.84719128
83MP0000955_abnormal_spinal_cord0.83631551
84MP0003935_abnormal_craniofacial_develop0.83581391
85MP0001963_abnormal_hearing_physiology0.82626512
86MP0001970_abnormal_pain_threshold0.81547418
87MP0000372_irregular_coat_pigmentation0.80974814
88MP0001440_abnormal_grooming_behavior0.80461377
89MP0004233_abnormal_muscle_weight0.79369484
90MP0002822_catalepsy0.78478365
91MP0001905_abnormal_dopamine_level0.77858109
92MP0004742_abnormal_vestibular_system0.77208508
93MP0004924_abnormal_behavior0.74342079
94MP0005386_behavior/neurological_phenoty0.74342079
95MP0001293_anophthalmia0.73705596
96* MP0002697_abnormal_eye_size0.73028053
97MP0002938_white_spotting0.71002805
98MP0000534_abnormal_ureter_morphology0.67654628
99MP0002066_abnormal_motor_capabilities/c0.67349976
100MP0000049_abnormal_middle_ear0.66157038
101MP0003890_abnormal_embryonic-extraembry0.65051732
102MP0003942_abnormal_urinary_system0.65040786
103MP0000026_abnormal_inner_ear0.64178153
104MP0001299_abnormal_eye_distance/0.63694483
105MP0001501_abnormal_sleep_pattern0.63004288
106MP0002733_abnormal_thermal_nociception0.60435591
107MP0004145_abnormal_muscle_electrophysio0.60160121
108MP0003137_abnormal_impulse_conducting0.58549210
109MP0003755_abnormal_palate_morphology0.58507530
110MP0002081_perinatal_lethality0.57894039
111MP0002735_abnormal_chemical_nociception0.56930690
112MP0002092_abnormal_eye_morphology0.56738666
113MP0004133_heterotaxia0.56064633
114MP0004085_abnormal_heartbeat0.56056514
115MP0002234_abnormal_pharynx_morphology0.55566734
116MP0009250_abnormal_appendicular_skeleto0.53159600
117MP0002089_abnormal_postnatal_growth/wei0.51815822
118MP0009780_abnormal_chondrocyte_physiolo0.50854180
119MP0001177_atelectasis0.50045447
120MP0004134_abnormal_chest_morphology0.49772892
121* MP0005187_abnormal_penis_morphology0.49367010
122MP0004142_abnormal_muscle_tone0.48214248
123MP0002069_abnormal_eating/drinking_beha0.47581180
124MP0002102_abnormal_ear_morphology0.47295690
125MP0000569_abnormal_digit_pigmentation0.47028530

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.75972037
2Abnormal rod and cone electroretinograms (HP:0008323)8.97922119
3Chorioretinal atrophy (HP:0000533)8.95252366
4Absent rod-and cone-mediated responses on ERG (HP:0007688)8.85309702
5Pigmentary retinal degeneration (HP:0001146)7.61974723
6Pendular nystagmus (HP:0012043)7.41093673
7Central scotoma (HP:0000603)6.68499159
8Attenuation of retinal blood vessels (HP:0007843)6.44388060
9Abnormality of macular pigmentation (HP:0008002)6.26819140
10Scotoma (HP:0000575)5.85353279
11Abolished electroretinogram (ERG) (HP:0000550)5.74289772
12Decreased central vision (HP:0007663)5.58964529
13Dyschromatopsia (HP:0007641)5.49902477
14Type II diabetes mellitus (HP:0005978)5.19647364
15Increased corneal curvature (HP:0100692)5.05676150
16Keratoconus (HP:0000563)5.05676150
17Vitreoretinal degeneration (HP:0000655)4.73250410
18Photophobia (HP:0000613)4.71851566
19Cone-rod dystrophy (HP:0000548)4.33395365
20Severe visual impairment (HP:0001141)4.31880275
21Abnormality of the phalanges of the 2nd finger (HP:0009541)4.11262925
22Macular degeneration (HP:0000608)3.90327927
23Retinitis pigmentosa (HP:0000510)3.80681592
24Posterior subcapsular cataract (HP:0007787)3.74648851
25Constricted visual fields (HP:0001133)3.54957577
26Abnormality of the 2nd finger (HP:0004100)3.52818992
27Limb dystonia (HP:0002451)3.48425066
28Choroideremia (HP:0001139)3.47515342
29Gait imbalance (HP:0002141)2.96029937
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.92230085
31Congenital primary aphakia (HP:0007707)2.86277622
32Hyperventilation (HP:0002883)2.70301415
33Mesomelia (HP:0003027)2.65998550
34Intestinal atresia (HP:0011100)2.54530318
35Aplasia of the musculature (HP:0100854)2.52826696
36Nephrogenic diabetes insipidus (HP:0009806)2.52310226
37Buphthalmos (HP:0000557)2.48509183
38Cortical dysplasia (HP:0002539)2.44375785
39Deformed tarsal bones (HP:0008119)2.41458373
40Morphological abnormality of the middle ear (HP:0008609)2.38834226
41Medial flaring of the eyebrow (HP:0010747)2.38634552
42Wide nasal bridge (HP:0000431)2.33911170
43Wide anterior fontanel (HP:0000260)2.25711443
44Optic disc pallor (HP:0000543)2.25610079
45Febrile seizures (HP:0002373)2.23488723
46Progressive cerebellar ataxia (HP:0002073)2.19805415
47Nephronophthisis (HP:0000090)2.18935485
48Protrusio acetabuli (HP:0003179)2.18788361
49Anomalous pulmonary venous return (HP:0010772)2.17246390
50Shawl scrotum (HP:0000049)2.16746544
51Subcapsular cataract (HP:0000523)2.15398397
52Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.14001435
53Chronic hepatic failure (HP:0100626)2.13169391
54Abnormality of the 4th metacarpal (HP:0010012)2.12436109
55Vaginal atresia (HP:0000148)2.11993969
56Genital tract atresia (HP:0001827)2.11806144
57Progressive visual loss (HP:0000529)2.10978288
58Aplasia/Hypoplasia of the lens (HP:0008063)2.07315659
59Coronal craniosynostosis (HP:0004440)2.06276211
60Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05197864
61Abnormality of the pulmonary veins (HP:0011718)2.04882466
62Poor coordination (HP:0002370)2.03611949
63Chin dimple (HP:0010751)2.03189628
64Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.02553233
65Visual hallucinations (HP:0002367)2.01259964
66Congenital stationary night blindness (HP:0007642)11.9571575
67Lissencephaly (HP:0001339)1.99641967
68Abnormality of the phalanges of the 5th finger (HP:0004213)1.96013946
69Abnormality of dentin (HP:0010299)1.94868906
70Pelvic girdle muscle weakness (HP:0003749)1.92576329
71Protruding tongue (HP:0010808)1.90135044
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89959438
73Short 1st metacarpal (HP:0010034)1.89959438
74Retinal atrophy (HP:0001105)1.88897418
75Hypothermia (HP:0002045)1.88409451
76Partial duplication of the phalanx of hand (HP:0009999)1.86545224
77Cutaneous finger syndactyly (HP:0010554)1.85457730
78Bowel diverticulosis (HP:0005222)1.84582280
79Narrow nasal bridge (HP:0000446)1.83606292
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83358023
81Esotropia (HP:0000565)1.83156242
82Pachygyria (HP:0001302)1.81246802
83Annular pancreas (HP:0001734)1.80044282
84Epileptic encephalopathy (HP:0200134)1.79264789
85Abnormality of the hip-girdle musculature (HP:0001445)1.77891717
86Abnormality of the musculature of the pelvis (HP:0001469)1.77891717
87Congenital sensorineural hearing impairment (HP:0008527)1.77844779
88Failure to thrive in infancy (HP:0001531)1.77526532
89Aortic aneurysm (HP:0004942)1.72866687
90Elfin facies (HP:0004428)1.72455554
91Atrioventricular canal defect (HP:0006695)1.71155011
92Supernumerary spleens (HP:0009799)1.70169722
93Focal seizures (HP:0007359)1.70106441
94True hermaphroditism (HP:0010459)1.69860290
95Wrist flexion contracture (HP:0001239)1.69447301
96Turricephaly (HP:0000262)1.69303748
97Synostosis involving the elbow (HP:0003938)1.69135815
98Humeroradial synostosis (HP:0003041)1.69135815
99Polyphagia (HP:0002591)1.69131693
100Abnormality of the renal medulla (HP:0100957)1.68699449
101Esophageal atresia (HP:0002032)1.68391092
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.68353033
103Pancreatic fibrosis (HP:0100732)1.67731948
104Short phalanx of the thumb (HP:0009660)1.66645757
105Neonatal short-limb short stature (HP:0008921)1.66406289
106Hypoplastic nipples (HP:0002557)1.66114126
107Overgrowth (HP:0001548)1.65596684
108Pheochromocytoma (HP:0002666)1.64818550
109Abnormality of the phalanges of the hallux (HP:0010057)1.64759047
110Premature rupture of membranes (HP:0001788)1.63963798
111Abnormality of the aortic arch (HP:0012303)1.63807698
112Septo-optic dysplasia (HP:0100842)1.62373654
113Abnormality of the 1st metacarpal (HP:0010009)1.62003499
114Dialeptic seizures (HP:0011146)1.61762320
115Bladder diverticulum (HP:0000015)1.60679567
116Type 1 muscle fiber predominance (HP:0003803)1.60096402
117Insomnia (HP:0100785)1.59195506
118Increased number of teeth (HP:0011069)1.59179005
119Sacral dimple (HP:0000960)1.58905685
120Short foot (HP:0001773)1.58708514
121Abnormality of midbrain morphology (HP:0002418)1.57912100
122Specific learning disability (HP:0001328)1.53912108
123Severe Myopia (HP:0011003)1.53069246
124Renovascular hypertension (HP:0100817)1.51191753
125Myokymia (HP:0002411)1.50257989
126Dysdiadochokinesis (HP:0002075)1.48266007
127Atonic seizures (HP:0010819)1.45042057
128Action tremor (HP:0002345)1.44385863
129Optic atrophy (HP:0000648)1.41958534
130Mask-like facies (HP:0000298)1.41816989
131Truncal ataxia (HP:0002078)1.41584459
132Absence seizures (HP:0002121)1.41408608
133Horizontal nystagmus (HP:0000666)1.39716047
134Sclerocornea (HP:0000647)1.39303629
135Palpebral edema (HP:0100540)1.33521828
136Amblyopia (HP:0000646)1.32708421
137Renal duplication (HP:0000075)1.32237526
138Broad-based gait (HP:0002136)1.30163866
139Asymmetry of the thorax (HP:0001555)1.29588170
140Hyperacusis (HP:0010780)1.29575526
141Pancreatic cysts (HP:0001737)1.26295065
142Short 4th metacarpal (HP:0010044)1.25521153
143Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.25521153
144Decreased testicular size (HP:0008734)1.24082039
145Focal motor seizures (HP:0011153)1.23894291
146Overriding aorta (HP:0002623)1.22108203
147Cystic liver disease (HP:0006706)1.21267883
148Abnormality of the lower motor neuron (HP:0002366)1.20793014
149Postaxial hand polydactyly (HP:0001162)1.20753941
150Vertebral arch anomaly (HP:0008438)1.19790824
151Broad foot (HP:0001769)1.19718995
152Agitation (HP:0000713)1.17981700
153Abnormality of the intervertebral disk (HP:0005108)1.17511887
154Genetic anticipation (HP:0003743)1.16794841
155Anosmia (HP:0000458)1.15359923
156Exotropia (HP:0000577)1.14930282
157Polar cataract (HP:0010696)1.13770580
158Abnormality of the corticospinal tract (HP:0002492)1.13734150
159Hypoventilation (HP:0002791)1.13048949
160Anophthalmia (HP:0000528)1.11382344
161Flat cornea (HP:0007720)1.09988008
162Zonular cataract (HP:0010920)1.08719544
163Hypermetropia (HP:0000540)1.07906941
164Chorioretinal coloboma (HP:0000567)1.07595364
165Excessive salivation (HP:0003781)1.05836941
166Drooling (HP:0002307)1.05836941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB36.84387946
2BMPR24.77827067
3GRK13.96997607
4SIK23.45528083
5EPHA32.92029117
6PBK2.85537823
7MARK12.74837790
8NTRK22.71232164
9SIK32.70671441
10SIK11.89011723
11PLK41.83332215
12PNCK1.70247606
13MAP3K41.69988276
14IRAK21.50004486
15SGK2231.48588038
16SGK4941.48588038
17MINK11.42049320
18PLK21.37775968
19MAP2K71.30667374
20MAP3K61.29923378
21INSRR1.29107357
22NTRK31.22685138
23DYRK1A1.14277322
24ERBB21.14187766
25LMTK21.14167433
26MAPK131.13835524
27CASK1.12849372
28HIPK21.12667356
29CAMK1G1.11396721
30DYRK21.10951632
31PAK61.08843818
32SGK21.08196199
33ADRBK11.07965302
34MYLK1.03779075
35TLK11.02302153
36PKN11.02107608
37MAP3K100.98902623
38CSNK1G20.98061406
39DYRK1B0.97020879
40PRPF4B0.90443188
41UHMK10.89256002
42PINK10.89253336
43GRK70.89157092
44WNK40.88996568
45LIMK10.87482970
46PRKCE0.84619399
47CSNK1G30.83430179
48PHKG20.82668792
49PHKG10.82668792
50WNK10.82389252
51NEK90.81828090
52NTRK10.81487471
53GRK50.79742885
54KSR10.78739680
55SGK30.78023663
56CSNK1A1L0.77938363
57PAK20.77194504
58PLK30.76887092
59FGFR20.76284677
60MAP2K40.75899306
61CDK50.75835710
62EPHA40.75664166
63CAMKK10.74910564
64ADRBK20.74355055
65PRKCG0.69569259
66MAPK150.68123247
67PRKCZ0.66728443
68PDGFRB0.65034121
69CDK180.63807600
70FLT30.62731526
71BRD40.62161928
72CDK150.60286288
73CAMK2G0.59930296
74MAPK90.59819060
75EPHB20.59729113
76PTK20.59642778
77STK380.59472309
78BMPR1B0.57431079
79PRKAA10.56283134
80CAMK2B0.55757246
81STK390.54546813
82DAPK20.53978690
83CSNK1G10.53493356
84CDK11A0.53475120
85LATS10.53366220
86WNK30.53322232
87DYRK30.52950882
88CDK140.52704189
89BCR0.52273156
90ICK0.51702770
91CAMK2D0.51656765
92RET0.50104233
93LATS20.49616995
94MKNK20.49481872
95CAMK2A0.49195790
96ERBB40.49093491
97MARK20.48481592
98MAP3K90.47772101
99CSNK1D0.47495257
100PRKCH0.47276402
101PRKG10.46823958
102CDK190.46640747
103RPS6KA20.46187683
104CDK30.45974728
105PRKCB0.45776105
106TESK10.44468512
107YES10.44367802
108AKT30.44083500
109MAPK80.43491846
110NLK0.43131405
111GSK3B0.42941347
112OBSCN0.42074283
113MKNK10.41799823
114TYRO30.41765587
115CAMK40.41266962
116PAK30.40303801
117ROCK10.39969212
118DDR20.39778568
119PRKACA0.39141269
120PDGFRA0.39054808
121PRKD20.37968964
122PIK3CA0.37634996
123FER0.37298469
124SGK10.36768543
125STK110.35945657
126RIPK10.35471235
127RPS6KA60.35184333
128RPS6KA30.34881610
129RPS6KL10.34702427
130RPS6KC10.34702427
131TNIK0.34213914
132CAMK10.34103185
133MAPK140.33373352

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.43879545
2Olfactory transduction_Homo sapiens_hsa047402.36393205
3Phototransduction_Homo sapiens_hsa0474413.1079914
4GABAergic synapse_Homo sapiens_hsa047271.85684281
5Cholinergic synapse_Homo sapiens_hsa047251.68798899
6Nicotine addiction_Homo sapiens_hsa050331.64742947
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61521814
8Circadian entrainment_Homo sapiens_hsa047131.60667727
9Dopaminergic synapse_Homo sapiens_hsa047281.55254810
10Glutamatergic synapse_Homo sapiens_hsa047241.51505617
11Morphine addiction_Homo sapiens_hsa050321.46996583
12Serotonergic synapse_Homo sapiens_hsa047261.33538268
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15279340
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07254787
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00083798
16ECM-receptor interaction_Homo sapiens_hsa045120.97538509
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96490656
18Insulin secretion_Homo sapiens_hsa049110.95468785
19Circadian rhythm_Homo sapiens_hsa047100.95280148
20Cocaine addiction_Homo sapiens_hsa050300.90627066
21Parkinsons disease_Homo sapiens_hsa050120.90060396
22Dorso-ventral axis formation_Homo sapiens_hsa043200.89823509
23Amphetamine addiction_Homo sapiens_hsa050310.89316920
24Alcoholism_Homo sapiens_hsa050340.89189839
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88123144
26Axon guidance_Homo sapiens_hsa043600.85394767
27Taste transduction_Homo sapiens_hsa047420.84874330
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84727026
29Oxytocin signaling pathway_Homo sapiens_hsa049210.84224733
30TGF-beta signaling pathway_Homo sapiens_hsa043500.84060411
31Long-term potentiation_Homo sapiens_hsa047200.83287750
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83065698
33Oxidative phosphorylation_Homo sapiens_hsa001900.81555676
34Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80648170
35Alzheimers disease_Homo sapiens_hsa050100.80307697
36Rap1 signaling pathway_Homo sapiens_hsa040150.79591958
37Gastric acid secretion_Homo sapiens_hsa049710.77019994
38Type II diabetes mellitus_Homo sapiens_hsa049300.76783760
39Long-term depression_Homo sapiens_hsa047300.70604506
40Renin secretion_Homo sapiens_hsa049240.70539187
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70488020
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69593061
43Salivary secretion_Homo sapiens_hsa049700.68146631
44cAMP signaling pathway_Homo sapiens_hsa040240.67685273
45Endometrial cancer_Homo sapiens_hsa052130.67527503
46Glioma_Homo sapiens_hsa052140.66282766
47Gap junction_Homo sapiens_hsa045400.65917713
48Prolactin signaling pathway_Homo sapiens_hsa049170.65536341
49Protein digestion and absorption_Homo sapiens_hsa049740.63157265
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63038012
51Huntingtons disease_Homo sapiens_hsa050160.61258963
52Focal adhesion_Homo sapiens_hsa045100.61147656
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59470484
54Systemic lupus erythematosus_Homo sapiens_hsa053220.59203780
55Colorectal cancer_Homo sapiens_hsa052100.58978084
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57223268
57Notch signaling pathway_Homo sapiens_hsa043300.56227190
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55006813
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54571380
60Dilated cardiomyopathy_Homo sapiens_hsa054140.52709441
61GnRH signaling pathway_Homo sapiens_hsa049120.52308556
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51721824
63Collecting duct acid secretion_Homo sapiens_hsa049660.51596159
64Wnt signaling pathway_Homo sapiens_hsa043100.51028068
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50395114
66Hedgehog signaling pathway_Homo sapiens_hsa043400.49567447
67mRNA surveillance pathway_Homo sapiens_hsa030150.49289117
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49057775
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48967323
70Vibrio cholerae infection_Homo sapiens_hsa051100.48930511
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48575887
72ErbB signaling pathway_Homo sapiens_hsa040120.48233466
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48051992
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47925847
75Hippo signaling pathway_Homo sapiens_hsa043900.47537014
76MicroRNAs in cancer_Homo sapiens_hsa052060.46641001
77Cardiac muscle contraction_Homo sapiens_hsa042600.46298645
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45969062
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45746133
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.45028742
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.44591637
82Estrogen signaling pathway_Homo sapiens_hsa049150.44542553
83Melanogenesis_Homo sapiens_hsa049160.44281836
84mTOR signaling pathway_Homo sapiens_hsa041500.43947686
85Tight junction_Homo sapiens_hsa045300.43453761
86Retinol metabolism_Homo sapiens_hsa008300.41843045
87Basal cell carcinoma_Homo sapiens_hsa052170.41302546
88Regulation of autophagy_Homo sapiens_hsa041400.41209459
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41103150
90Non-small cell lung cancer_Homo sapiens_hsa052230.40084264
91Inositol phosphate metabolism_Homo sapiens_hsa005620.39766442
92Chronic myeloid leukemia_Homo sapiens_hsa052200.39520975
93Calcium signaling pathway_Homo sapiens_hsa040200.39159822
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36967469
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36640234
96Ras signaling pathway_Homo sapiens_hsa040140.35631091
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35106295
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34985153
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33964903
100Tyrosine metabolism_Homo sapiens_hsa003500.33875479
101Renal cell carcinoma_Homo sapiens_hsa052110.33631916
102Thyroid hormone synthesis_Homo sapiens_hsa049180.33099219
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.32163078
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31940222
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31662337
106MAPK signaling pathway_Homo sapiens_hsa040100.31150436
107Choline metabolism in cancer_Homo sapiens_hsa052310.31140181
108AMPK signaling pathway_Homo sapiens_hsa041520.29601522
109FoxO signaling pathway_Homo sapiens_hsa040680.27634833
110Pancreatic secretion_Homo sapiens_hsa049720.27228995
111Glucagon signaling pathway_Homo sapiens_hsa049220.26363647
112ABC transporters_Homo sapiens_hsa020100.25665959
113Bile secretion_Homo sapiens_hsa049760.24425293
114Chemokine signaling pathway_Homo sapiens_hsa040620.24391746
115Melanoma_Homo sapiens_hsa052180.23895440
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.23628527
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21117701
118Oocyte meiosis_Homo sapiens_hsa041140.20811364
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.20365592
120Insulin signaling pathway_Homo sapiens_hsa049100.19380586
121Adherens junction_Homo sapiens_hsa045200.17313247
122VEGF signaling pathway_Homo sapiens_hsa043700.16919534
123Proteoglycans in cancer_Homo sapiens_hsa052050.15754290
124Ovarian steroidogenesis_Homo sapiens_hsa049130.15549188
125Pathways in cancer_Homo sapiens_hsa052000.15432332

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