M6PR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69323359
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59511745
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59511745
4antigen processing and presentation of endogenous antigen (GO:0019883)4.43635536
5glycosphingolipid catabolic process (GO:0046479)4.19836237
6oligosaccharide catabolic process (GO:0009313)3.97831824
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94641705
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.94641705
9modulation by symbiont of host immune response (GO:0052553)3.94641705
10positive regulation by symbiont of host defense response (GO:0052509)3.94641705
11modulation by symbiont of host defense response (GO:0052031)3.94641705
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94641705
13immunoglobulin mediated immune response (GO:0016064)3.94417612
14neutrophil activation involved in immune response (GO:0002283)3.93961470
15glycolipid catabolic process (GO:0019377)3.84013482
16response to peptidoglycan (GO:0032494)3.76634450
17polyketide metabolic process (GO:0030638)3.73074158
18doxorubicin metabolic process (GO:0044598)3.73074158
19daunorubicin metabolic process (GO:0044597)3.73074158
20negative regulation of cell killing (GO:0031342)3.63446669
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63446669
22positive regulation of interferon-alpha production (GO:0032727)3.59159105
23cellular response to thyroid hormone stimulus (GO:0097067)3.51429293
24regulation of interferon-alpha production (GO:0032647)3.42730827
25amino sugar catabolic process (GO:0046348)3.35668575
26B cell mediated immunity (GO:0019724)3.34698152
27positive regulation of gamma-delta T cell activation (GO:0046645)3.30999916
28regulation of interferon-beta biosynthetic process (GO:0045357)3.29423639
29ceramide catabolic process (GO:0046514)3.27994820
30cellular extravasation (GO:0045123)3.26457177
31regulation of B cell receptor signaling pathway (GO:0050855)3.19787556
32positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.16486149
33regulation of mononuclear cell migration (GO:0071675)3.13259806
34regulation of superoxide anion generation (GO:0032928)3.12412763
35detection of other organism (GO:0098543)3.11018308
36Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09276970
37regulation of mast cell degranulation (GO:0043304)3.06630163
38response to thyroid hormone (GO:0097066)3.05472921
39interferon-gamma production (GO:0032609)3.05039234
40positive regulation of monocyte chemotaxis (GO:0090026)3.04037754
41natural killer cell mediated cytotoxicity (GO:0042267)3.00724072
42natural killer cell mediated immunity (GO:0002228)3.00724072
43regulation of T cell tolerance induction (GO:0002664)3.00602058
44regulation of interleukin-2 biosynthetic process (GO:0045076)2.92244952
45respiratory burst (GO:0045730)2.89639398
46detection of bacterium (GO:0016045)2.89421613
47positive regulation of mast cell activation (GO:0033005)2.87345609
48regulation of leukocyte degranulation (GO:0043300)2.84162233
49leukocyte mediated cytotoxicity (GO:0001909)2.83216663
50negative regulation of phagocytosis (GO:0050765)2.81328176
51NIK/NF-kappaB signaling (GO:0038061)2.80881128
52positive regulation of chemokine biosynthetic process (GO:0045080)2.80494082
53macrophage activation involved in immune response (GO:0002281)2.80452367
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.79966264
55type I interferon signaling pathway (GO:0060337)2.78081178
56cellular response to type I interferon (GO:0071357)2.78081178
57response to muramyl dipeptide (GO:0032495)2.77835351
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76944278
59response to type I interferon (GO:0034340)2.76616331
60positive regulation of leukocyte degranulation (GO:0043302)2.76456443
61positive regulation of protein import into nucleus, translocation (GO:0033160)2.76394862
62pinocytosis (GO:0006907)2.73371893
63positive regulation of antigen processing and presentation (GO:0002579)2.73330719
64interferon-gamma-mediated signaling pathway (GO:0060333)2.72812235
65positive regulation of B cell differentiation (GO:0045579)2.72284915
66eosinophil chemotaxis (GO:0048245)2.71923211
67aminoglycoside antibiotic metabolic process (GO:0030647)2.71883663
68membrane lipid catabolic process (GO:0046466)2.71650576
69regulation of tolerance induction (GO:0002643)2.71617953
70regulation of mast cell activation involved in immune response (GO:0033006)2.70955192
71response to interferon-beta (GO:0035456)2.68758833
72response to host immune response (GO:0052572)2.65668878
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65668878
74myeloid dendritic cell differentiation (GO:0043011)2.64616568
75positive regulation of interferon-beta production (GO:0032728)2.63722136
76antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.63492843
77sphingolipid catabolic process (GO:0030149)2.62707621
78regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62068343
79positive regulation of defense response to virus by host (GO:0002230)2.61700258
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61643872
81regulation of podosome assembly (GO:0071801)2.61615879
82detection of external biotic stimulus (GO:0098581)2.61223581
83cellular response to interferon-gamma (GO:0071346)2.60961187
84regulation of chemokine biosynthetic process (GO:0045073)2.60065057
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60021459
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.59502700
87T cell migration (GO:0072678)2.59092486
88T-helper 1 type immune response (GO:0042088)2.57209173
89positive regulation of isotype switching (GO:0045830)2.56624507
90neutrophil activation (GO:0042119)2.56479551
91myeloid dendritic cell activation (GO:0001773)2.56331101
92positive regulation of mast cell degranulation (GO:0043306)2.56155509
93positive regulation of mast cell activation involved in immune response (GO:0033008)2.56155509
94response to interferon-alpha (GO:0035455)2.55729981
95protein localization to kinetochore (GO:0034501)2.55491993
96monocyte chemotaxis (GO:0002548)2.55427962
97defense response to protozoan (GO:0042832)2.55383570
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54140305
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.53720717
100granulocyte activation (GO:0036230)2.53523722
101eosinophil migration (GO:0072677)2.52906246
102N-acetylneuraminate metabolic process (GO:0006054)2.52640028
103regulation of growth of symbiont in host (GO:0044126)2.51843227
104negative regulation of growth of symbiont in host (GO:0044130)2.51843227
105negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.51843227
106modulation of growth of symbiont involved in interaction with host (GO:0044144)2.51843227
107dendritic cell differentiation (GO:0097028)2.51822954
108regulation of mast cell activation (GO:0033003)2.51034394
109regulation of B cell differentiation (GO:0045577)2.50820749
110regulation of macrophage chemotaxis (GO:0010758)2.49938174
111regulation of vitamin D biosynthetic process (GO:0060556)2.49829469
112reactive oxygen species biosynthetic process (GO:1903409)2.49129352
113regulation of antigen processing and presentation (GO:0002577)2.48586558
114negative regulation of interleukin-12 production (GO:0032695)2.48004823
115leukocyte aggregation (GO:0070486)2.47861750
116response to protozoan (GO:0001562)2.47711082
117regulation of lymphocyte chemotaxis (GO:1901623)2.47456494
118myeloid cell activation involved in immune response (GO:0002275)2.47045217
119negative regulation of interleukin-17 production (GO:0032700)2.46858672
120peptide catabolic process (GO:0043171)2.46804671
121regulation of lymphocyte migration (GO:2000401)2.46757559
122cellular response to interferon-beta (GO:0035458)2.46010733
123pentose-phosphate shunt (GO:0006098)2.45552901
124positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.45002629
125response to interferon-gamma (GO:0034341)2.44497581
126regulation of necroptotic process (GO:0060544)2.44199201
127detection of molecule of bacterial origin (GO:0032490)2.43949684
128T cell costimulation (GO:0031295)2.43619355
129macrophage differentiation (GO:0030225)2.43480602
130regulation of response to interferon-gamma (GO:0060330)2.42971263
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42873258
132lymphocyte mediated immunity (GO:0002449)2.39942819
133nuclear pore complex assembly (GO:0051292)2.39329193
134hydrogen peroxide biosynthetic process (GO:0050665)2.38695666
135establishment of endothelial barrier (GO:0061028)2.38504415
136membrane protein intracellular domain proteolysis (GO:0031293)2.38061676
137regulation of gamma-delta T cell differentiation (GO:0045586)2.37379013
138response to host (GO:0075136)2.37111212
139response to host defenses (GO:0052200)2.37111212
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37111212
141hepatocyte apoptotic process (GO:0097284)2.36964433
142positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36193060
143regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34467887
144positive regulation of tumor necrosis factor production (GO:0032760)2.33902861
145positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.33149166
146production of molecular mediator involved in inflammatory response (GO:0002532)2.32831809
147positive regulation of cytokine biosynthetic process (GO:0042108)2.32766333
148natural killer cell activation (GO:0030101)2.32408338
149regulation of gamma-delta T cell activation (GO:0046643)2.32128010
150positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32020775
151neutrophil mediated immunity (GO:0002446)2.31995858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25703162
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.48106735
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.16695229
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.83845788
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07906079
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.84368435
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.51332879
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48105639
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45542522
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41497891
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34573149
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34450086
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30451250
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28635481
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28410993
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18254674
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15211375
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08660567
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02325795
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00538017
21* SPI1_23547873_ChIP-Seq_NB4_Human1.98629969
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90978074
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90616200
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80713998
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78989388
26SCL_19346495_ChIP-Seq_HPC-7_Human1.73939498
27MYC_22102868_ChIP-Seq_BL_Human1.71282489
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.71019325
29MYB_26560356_Chip-Seq_TH2_Human1.70628712
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70593345
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70111405
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69113291
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68345842
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67768331
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.62148909
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61045920
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60177142
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60177142
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60177142
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55873318
41GATA1_22025678_ChIP-Seq_K562_Human1.52694756
42VDR_21846776_ChIP-Seq_THP-1_Human1.52256923
43MYB_26560356_Chip-Seq_TH1_Human1.51443806
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50604210
45* RUNX1_22412390_ChIP-Seq_EML_Mouse1.50419447
46MAF_26560356_Chip-Seq_TH1_Human1.50277710
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49351660
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45062659
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41595275
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40647142
51* GABP_17652178_ChIP-ChIP_JURKAT_Human1.35971669
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34708600
53* TFEB_21752829_ChIP-Seq_HELA_Human1.32720760
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31481352
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29690430
56* EST1_17652178_ChIP-ChIP_JURKAT_Human1.29560068
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27885389
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26714019
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23706811
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.23694514
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23103394
62VDR_23849224_ChIP-Seq_CD4+_Human1.21779528
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20687052
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20416616
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18005441
66VDR_24763502_ChIP-Seq_THP-1_Human1.17245404
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15838135
68UTX_26944678_Chip-Seq_JUKART_Human1.15000752
69* ELK1_19687146_ChIP-ChIP_HELA_Human1.14039561
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13191941
71* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13105177
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12752137
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12328320
74SPI1_23127762_ChIP-Seq_K562_Human1.12029637
75VDR_24787735_ChIP-Seq_THP-1_Human1.11951578
76* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10373095
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09056702
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08599911
79FOXP3_21729870_ChIP-Seq_TREG_Human1.07987143
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06904035
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06746130
82RUNX_20019798_ChIP-Seq_JUKART_Human1.06706030
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06135871
84* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04702325
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04309622
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01772495
87PU_27001747_Chip-Seq_BMDM_Mouse1.01622174
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01597469
89* GATA3_27048872_Chip-Seq_THYMUS_Human1.00398013
90TCF7_22412390_ChIP-Seq_EML_Mouse1.00315529
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00140627
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00140427
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00088967
94AR_21909140_ChIP-Seq_LNCAP_Human0.99342938
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98947108
96* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98839735
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98334958
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97712827
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97058937
100ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95482936
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95360362
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94370536
103SRF_21415370_ChIP-Seq_HL-1_Mouse0.93547665
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91460243
105XRN2_22483619_ChIP-Seq_HELA_Human0.90925974
106* ETS1_20019798_ChIP-Seq_JURKAT_Human0.90101405
107MAF_26560356_Chip-Seq_TH2_Human0.89556135
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.89528252
109GATA3_26560356_Chip-Seq_TH2_Human0.89484111
110E2F1_21310950_ChIP-Seq_MCF-7_Human0.89457863
111NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88691007
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88318284
113CIITA_25753668_ChIP-Seq_RAJI_Human0.88057103
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86919406
115DCP1A_22483619_ChIP-Seq_HELA_Human0.86555164
116* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86146204
117NCOR1_26117541_ChIP-Seq_K562_Human0.86055218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.02590894
2MP0003436_decreased_susceptibility_to3.12721061
3MP0009785_altered_susceptibility_to2.98621958
4MP0006082_CNS_inflammation2.81744541
5MP0005000_abnormal_immune_tolerance2.57687629
6MP0000685_abnormal_immune_system2.51527987
7MP0005671_abnormal_response_to2.48958344
8MP0002148_abnormal_hypersensitivity_rea2.44505527
9MP0005025_abnormal_response_to2.43608704
10MP0001790_abnormal_immune_system2.34923602
11MP0005387_immune_system_phenotype2.34923602
12MP0002419_abnormal_innate_immunity2.34895473
13MP0001800_abnormal_humoral_immune2.26921869
14MP0002452_abnormal_antigen_presenting2.20747365
15MP0005058_abnormal_lysosome_morphology2.20435813
16MP0002723_abnormal_immune_serum2.12317992
17MP0002396_abnormal_hematopoietic_system2.01731393
18MP0001819_abnormal_immune_cell2.00338470
19MP0002420_abnormal_adaptive_immunity1.99765460
20MP0003724_increased_susceptibility_to1.98482480
21MP0001853_heart_inflammation1.97209276
22MP0005451_abnormal_body_composition1.97124650
23MP0003300_gastrointestinal_ulcer1.96765999
24MP0002254_reproductive_system_inflammat1.93795785
25MP0003303_peritoneal_inflammation1.92580382
26MP0008057_abnormal_DNA_replication1.85979341
27MP0002405_respiratory_system_inflammati1.85537874
28MP0010352_gastrointestinal_tract_polyps1.76701838
29MP0009333_abnormal_splenocyte_physiolog1.76169002
30MP0010155_abnormal_intestine_physiology1.70488078
31MP0002398_abnormal_bone_marrow1.69426117
32MP0005464_abnormal_platelet_physiology1.66722756
33MP0000716_abnormal_immune_system1.65597662
34MP0001845_abnormal_inflammatory_respons1.65320441
35MP0004947_skin_inflammation1.61959999
36MP0008260_abnormal_autophagy1.61209619
37MP0002166_altered_tumor_susceptibility1.60389361
38MP0000689_abnormal_spleen_morphology1.58277817
39MP0004264_abnormal_extraembryonic_tissu1.56024762
40MP0003186_abnormal_redox_activity1.54634440
41MP0003448_altered_tumor_morphology1.50670264
42MP0001533_abnormal_skeleton_physiology1.49515684
43MP0002429_abnormal_blood_cell1.48679879
44MP0002722_abnormal_immune_system1.48169675
45MP0008469_abnormal_protein_level1.48155407
46MP0003183_abnormal_peptide_metabolism1.47396591
47MP0003191_abnormal_cellular_cholesterol1.45525588
48MP0002006_tumorigenesis1.42745563
49MP0000490_abnormal_crypts_of1.42183847
50MP0005310_abnormal_salivary_gland1.41788882
51MP0003763_abnormal_thymus_physiology1.41568767
52MP0000858_altered_metastatic_potential1.40941856
53MP0000343_altered_response_to1.40833374
54MP0001545_abnormal_hematopoietic_system1.38307451
55MP0005397_hematopoietic_system_phenotyp1.38307451
56MP0009840_abnormal_foam_cell1.37226354
57MP0010307_abnormal_tumor_latency1.35185823
58MP0004957_abnormal_blastocyst_morpholog1.34225714
59MP0009764_decreased_sensitivity_to1.24688862
60MP0002139_abnormal_hepatobiliary_system1.22611601
61* MP0003172_abnormal_lysosome_physiology1.21459982
62MP0003566_abnormal_cell_adhesion1.19679307
63MP0005075_abnormal_melanosome_morpholog1.18889465
64MP0004782_abnormal_surfactant_physiolog1.18193030
65MP0000465_gastrointestinal_hemorrhage1.16928125
66MP0003806_abnormal_nucleotide_metabolis1.15270824
67MP0002877_abnormal_melanocyte_morpholog1.15024031
68MP0003828_pulmonary_edema1.14215035
69MP0003453_abnormal_keratinocyte_physiol1.08021254
70MP0000604_amyloidosis1.06975231
71MP0003075_altered_response_to1.04287742
72MP0004808_abnormal_hematopoietic_stem1.04061478
73MP0005166_decreased_susceptibility_to1.02863298
74MP0003693_abnormal_embryo_hatching1.00816552
75MP0002998_abnormal_bone_remodeling1.00524397
76MP0003705_abnormal_hypodermis_morpholog1.00355888
77MP0002138_abnormal_hepatobiliary_system0.99941622
78MP0003690_abnormal_glial_cell0.99151824
79MP0003011_delayed_dark_adaptation0.97690008
80MP0003077_abnormal_cell_cycle0.95530194
81MP0008007_abnormal_cellular_replicative0.95508594
82MP0005408_hypopigmentation0.95413362
83MP0001873_stomach_inflammation0.95402785
84MP0003656_abnormal_erythrocyte_physiolo0.94760844
85MP0009763_increased_sensitivity_to0.94206308
86MP0005023_abnormal_wound_healing0.94076682
87MP0002019_abnormal_tumor_incidence0.92059543
88MP0000609_abnormal_liver_physiology0.90968341
89MP0000015_abnormal_ear_pigmentation0.90814877
90MP0006054_spinal_hemorrhage0.90464296
91MP0000703_abnormal_thymus_morphology0.90009661
92MP0002277_abnormal_respiratory_mucosa0.87149360
93MP0001851_eye_inflammation0.85175121
94MP0010094_abnormal_chromosome_stability0.84451419
95MP0003329_amyloid_beta_deposits0.82765569
96MP0003866_abnormal_defecation0.81439403
97MP0004510_myositis0.81153383
98MP0000920_abnormal_myelination0.80132518
99MP0005165_increased_susceptibility_to0.79585186
100MP0002090_abnormal_vision0.79517607
101MP0002132_abnormal_respiratory_system0.79249947
102MP0000598_abnormal_liver_morphology0.77859368
103MP0000313_abnormal_cell_death0.76659361
104MP0000249_abnormal_blood_vessel0.75146682
105MP0000371_diluted_coat_color0.74735189
106MP0002332_abnormal_exercise_endurance0.74010484
107MP0010234_abnormal_vibrissa_follicle0.72778304
108MP0005390_skeleton_phenotype0.72562867
109MP0005164_abnormal_response_to0.72508305
110MP0002136_abnormal_kidney_physiology0.71812893
111MP0008873_increased_physiological_sensi0.71244718
112* MP0005319_abnormal_enzyme/_coenzyme0.70900946
113MP0003795_abnormal_bone_structure0.70582297
114MP0000350_abnormal_cell_proliferation0.69387596
115MP0009278_abnormal_bone_marrow0.69212479
116MP0003091_abnormal_cell_migration0.69106488
117MP0000358_abnormal_cell_content/0.66772309
118MP0001849_ear_inflammation0.64146892
119MP0000372_irregular_coat_pigmentation0.63787491
120MP0004883_abnormal_blood_vessel0.62861150
121MP0009765_abnormal_xenobiotic_induced0.61656024

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.16950702
2Eczematoid dermatitis (HP:0000976)4.63140413
3Recurrent bacterial skin infections (HP:0005406)4.62126627
4Elevated erythrocyte sedimentation rate (HP:0003565)4.12582614
5Abnormality of macrophages (HP:0004311)3.80420939
6Myositis (HP:0100614)3.69766622
7Vacuolated lymphocytes (HP:0001922)3.62045657
8Recurrent gram-negative bacterial infections (HP:0005420)3.49799351
9Increased cerebral lipofuscin (HP:0011813)3.36736309
10Abnormality of liposaccharide metabolism (HP:0010968)3.28811089
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.28811089
12Abnormality of glycolipid metabolism (HP:0010969)3.28811089
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.27984873
14Orchitis (HP:0100796)3.27319506
15Recurrent viral infections (HP:0004429)3.23934933
16Thrombocytosis (HP:0001894)3.22393546
17Disinhibition (HP:0000734)3.15686447
18Chronic otitis media (HP:0000389)3.03416463
19Recurrent fungal infections (HP:0002841)3.01912643
20Autoimmune thrombocytopenia (HP:0001973)2.99655905
21Mediastinal lymphadenopathy (HP:0100721)2.97962530
22Multiple enchondromatosis (HP:0005701)2.95824584
23Recurrent skin infections (HP:0001581)2.92507668
24Nasal polyposis (HP:0100582)2.84800423
25Petechiae (HP:0000967)2.79531353
26Gingivitis (HP:0000230)2.77716429
27Poor head control (HP:0002421)2.74773843
28Vasculitis (HP:0002633)2.66370197
29Abnormality of the nasal mucosa (HP:0000433)2.65730877
30Pustule (HP:0200039)2.64245098
31Abnormality of T cell physiology (HP:0011840)2.64028947
32Interstitial pulmonary disease (HP:0006530)2.64009807
33Periodontitis (HP:0000704)2.61433219
34IgM deficiency (HP:0002850)2.58478094
35Increased IgM level (HP:0003496)2.56915571
36Vertebral compression fractures (HP:0002953)2.48905572
37Dysostosis multiplex (HP:0000943)2.46965739
38Pulmonary infiltrates (HP:0002113)2.44699902
39Cellulitis (HP:0100658)2.42673449
40Systemic lupus erythematosus (HP:0002725)2.42189177
41Progressive neurologic deterioration (HP:0002344)2.41766671
42Chronic obstructive pulmonary disease (HP:0006510)2.39077158
43Obstructive lung disease (HP:0006536)2.39077158
44Stomatitis (HP:0010280)2.38948062
45Agnosia (HP:0010524)2.38533428
46Leukocytosis (HP:0001974)2.36770042
47Increased serum ferritin (HP:0003281)2.36374255
48Abnormality of T cells (HP:0002843)2.35623136
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.35265649
50Hematochezia (HP:0002573)2.31826254
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.29475767
52Osteolytic defects of the hand bones (HP:0009699)2.29475767
53Gingival bleeding (HP:0000225)2.28572731
54Reduced antithrombin III activity (HP:0001976)2.28314025
55Combined immunodeficiency (HP:0005387)2.27390075
56Basal ganglia calcification (HP:0002135)2.26987097
57Mucopolysacchariduria (HP:0008155)2.25502752
58Urinary glycosaminoglycan excretion (HP:0003541)2.25502752
59Spontaneous hematomas (HP:0007420)2.25034738
60Peritonitis (HP:0002586)2.24873535
61Mutism (HP:0002300)2.24053188
62Retrobulbar optic neuritis (HP:0100654)2.22086544
63Optic neuritis (HP:0100653)2.22086544
64Recurrent bronchitis (HP:0002837)2.21877547
65Upper motor neuron abnormality (HP:0002127)2.20338579
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19891821
67Chest pain (HP:0100749)2.19824248
68Diminished motivation (HP:0000745)2.19795099
69Abnormality of iron homeostasis (HP:0011031)2.19068855
70Abnormality of T cell number (HP:0011839)2.18360740
71Hypochromic microcytic anemia (HP:0004840)2.16769120
72Epistaxis (HP:0000421)2.14253473
73Urticaria (HP:0001025)2.11941707
74Abnormality of the prostate (HP:0008775)2.10686860
75Osteomyelitis (HP:0002754)2.10431910
76T lymphocytopenia (HP:0005403)2.10283320
77Apathy (HP:0000741)2.09557612
78Eosinophilia (HP:0001880)2.09162118
79Aplastic anemia (HP:0001915)2.08817797
80Hypergammaglobulinemia (HP:0010702)2.06611920
81Arterial thrombosis (HP:0004420)2.06304011
82Tetraparesis (HP:0002273)2.04632253
83Hypochromic anemia (HP:0001931)2.04488859
84Neurofibrillary tangles (HP:0002185)2.04030665
85Myocardial infarction (HP:0001658)2.02032042
86Meningitis (HP:0001287)2.00326091
87Abnormality of transition element cation homeostasis (HP:0011030)1.99851816
88Abnormality of the pleura (HP:0002103)1.97930879
89Purpura (HP:0000979)1.97929358
90Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96852169
91Abnormality of polysaccharide metabolism (HP:0011012)1.96852169
92Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96852169
93Granulocytopenia (HP:0001913)1.96481037
94Axonal loss (HP:0003447)1.96090897
95Hepatosplenomegaly (HP:0001433)1.94336237
96Global brain atrophy (HP:0002283)1.92054786
97Encephalitis (HP:0002383)1.91297815
98Loss of speech (HP:0002371)1.91076586
99Neuronal loss in central nervous system (HP:0002529)1.89798453
100Autoimmune hemolytic anemia (HP:0001890)1.87438413
101Personality changes (HP:0000751)1.87248287
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.86995998
103Chronic diarrhea (HP:0002028)1.85811601
104Amyloidosis (HP:0011034)1.85492797
105Keratoconjunctivitis sicca (HP:0001097)1.85170396
106Recurrent cutaneous fungal infections (HP:0011370)1.84491304
107Chronic mucocutaneous candidiasis (HP:0002728)1.84491304
108Amaurosis fugax (HP:0100576)1.84085175
109Thoracic kyphosis (HP:0002942)1.83922265
110Nuclear cataract (HP:0100018)1.83538173
111Anorexia (HP:0002039)1.82423455
112Hemoptysis (HP:0002105)1.82145694
113Premature loss of primary teeth (HP:0006323)1.81196591
114Bone pain (HP:0002653)1.80979161
115Skin ulcer (HP:0200042)1.80696781
116Pathologic fracture (HP:0002756)1.79867426
117Polyneuropathy (HP:0001271)1.79723425
118Glomerulopathy (HP:0100820)1.79569985
119IgA deficiency (HP:0002720)1.79076677
120Fatigue (HP:0012378)1.79053809
121Gastrointestinal infarctions (HP:0005244)1.78957144
122Restrictive lung disease (HP:0002091)1.78918893
123Cardiomegaly (HP:0001640)1.75937792
124Inflammation of the large intestine (HP:0002037)1.75867219
125Mucosal telangiectasiae (HP:0100579)1.73862166
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71735471
127Colitis (HP:0002583)1.71426114
128Splenomegaly (HP:0001744)1.71416585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.47110361
2ERN13.44316402
3MAP4K12.94126817
4STK102.85703384
5MAP3K142.76754512
6TYK22.75912683
7CSF1R2.55072705
8BLK2.50804908
9TGFBR22.50209535
10JAK32.32768631
11PRPF4B2.32341731
12TBK12.20020341
13GRK62.19650867
14IRAK42.13092067
15KIT2.04487490
16IRAK31.97688419
17IKBKB1.90633987
18TXK1.79681155
19FGR1.75724370
20ZAP701.75502159
21FES1.73718177
22TAOK21.59947788
23NME21.57689776
24PIM21.54997842
25MATK1.49419836
26CSK1.47906454
27LRRK21.47371286
28MST41.44245558
29IKBKE1.42713051
30JAK11.41829113
31PDK21.36652147
32PAK41.34817356
33TAOK31.34511297
34FLT31.33330236
35ITK1.28442750
36SMG11.24894439
37MAP3K131.20617794
38BMPR21.20045801
39MAP2K31.19588333
40BTK1.19032325
41TEC1.17690444
42CHUK1.13852307
43MAP3K121.11505862
44NEK91.10448179
45MOS1.09751350
46GRK51.08919939
47RIPK41.07796202
48SYK1.06627515
49VRK21.03221634
50PIM11.02101463
51GRK71.00655703
52JAK21.00328237
53ADRBK21.00256119
54LCK0.98912119
55EPHB10.98785872
56FGFR30.98676782
57SCYL20.97481626
58PBK0.94047436
59RPS6KA40.93127564
60GRK10.91612221
61LYN0.90177916
62FGFR40.90042227
63SIK30.88844673
64CLK10.85979100
65HCK0.82105114
66ABL20.80485732
67BRSK20.80156841
68STK40.79892857
69MAP3K100.78190867
70PRKG20.77511064
71DDR20.74605660
72MAP3K80.72648326
73CDK70.72527903
74TESK20.71351836
75TTK0.69702971
76EPHA20.68713582
77MAP3K30.66921131
78EIF2AK10.66422089
79CDK40.65760162
80EIF2AK20.65560020
81MAP3K10.64470925
82RPS6KB20.64436100
83KDR0.64076684
84RIPK10.63942967
85NEK20.62222256
86TAOK10.61469933
87PASK0.60226241
88PKN20.59166553
89ACVR1B0.58609442
90MARK30.58173705
91YES10.57810858
92WEE10.57645540
93EIF2AK30.57636798
94CDC70.57170963
95CDK60.55075397
96MAP3K50.54939337
97PRKCD0.54893845
98MAPK70.53082420
99NEK10.52978785
100STK240.52792375
101HIPK20.52512198
102MAP3K110.52152982
103TTN0.49620144
104TRIB30.49276371
105BMX0.48797974
106MKNK10.48106629
107TESK10.47739684
108MAPKAPK20.47376138
109MKNK20.46417739
110TGFBR10.46163029
111DAPK10.46016080
112PRKCQ0.44326477
113BUB10.43873998
114SRPK10.43043355
115CDC42BPA0.42387956
116ALK0.42229989
117ARAF0.41820353
118TSSK60.41256555
119EEF2K0.40864108
120IRAK20.39845863
121LIMK10.38865638
122ATR0.38415485
123EGFR0.38317117
124PTK60.38231837
125CAMKK20.37804026
126ABL10.37110730
127IGF1R0.36416704
128TRPM70.36312519
129CAMK1D0.36047445
130FYN0.30294323
131PDPK10.29945177
132PDK10.29874868
133INSR0.28411979
134CDK190.26634697

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.68068237
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.34452110
3Legionellosis_Homo sapiens_hsa051342.28904553
4Antigen processing and presentation_Homo sapiens_hsa046122.17924935
5Other glycan degradation_Homo sapiens_hsa005112.14278024
6Staphylococcus aureus infection_Homo sapiens_hsa051502.12703032
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08451279
8Allograft rejection_Homo sapiens_hsa053302.05999651
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.96394042
10Graft-versus-host disease_Homo sapiens_hsa053321.95855251
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92506928
12Measles_Homo sapiens_hsa051621.90205898
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89520069
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83318389
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.82600193
16DNA replication_Homo sapiens_hsa030301.81858753
17* Lysosome_Homo sapiens_hsa041421.74170737
18Herpes simplex infection_Homo sapiens_hsa051681.72163361
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71381090
20Osteoclast differentiation_Homo sapiens_hsa043801.62440987
21Malaria_Homo sapiens_hsa051441.61226255
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59456546
23Primary immunodeficiency_Homo sapiens_hsa053401.59316103
24Pertussis_Homo sapiens_hsa051331.58616806
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55727345
26Tuberculosis_Homo sapiens_hsa051521.52615105
27Influenza A_Homo sapiens_hsa051641.43739346
28Apoptosis_Homo sapiens_hsa042101.42358681
29One carbon pool by folate_Homo sapiens_hsa006701.40956757
30Hematopoietic cell lineage_Homo sapiens_hsa046401.39184418
31Caffeine metabolism_Homo sapiens_hsa002321.39093720
32Asthma_Homo sapiens_hsa053101.38804056
33Toxoplasmosis_Homo sapiens_hsa051451.36240886
34B cell receptor signaling pathway_Homo sapiens_hsa046621.26448038
35TNF signaling pathway_Homo sapiens_hsa046681.22415591
36Autoimmune thyroid disease_Homo sapiens_hsa053201.18092848
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18009741
38Mismatch repair_Homo sapiens_hsa034301.13756009
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.13099140
40Pentose phosphate pathway_Homo sapiens_hsa000301.11304191
41Rheumatoid arthritis_Homo sapiens_hsa053231.09935234
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09158112
43Type I diabetes mellitus_Homo sapiens_hsa049401.07746998
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07015636
45Shigellosis_Homo sapiens_hsa051311.05731502
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05647776
47Proteasome_Homo sapiens_hsa030501.05299314
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03437472
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03171786
50Collecting duct acid secretion_Homo sapiens_hsa049661.00935907
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98516178
52* Phagosome_Homo sapiens_hsa041450.94189825
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.92461742
54Vitamin B6 metabolism_Homo sapiens_hsa007500.91987592
55Salmonella infection_Homo sapiens_hsa051320.90033407
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86962030
57Fructose and mannose metabolism_Homo sapiens_hsa000510.85573251
58Hepatitis B_Homo sapiens_hsa051610.84566436
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84346560
60Ribosome_Homo sapiens_hsa030100.83641023
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82384716
62T cell receptor signaling pathway_Homo sapiens_hsa046600.79466513
63Acute myeloid leukemia_Homo sapiens_hsa052210.78061446
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77934365
65Hepatitis C_Homo sapiens_hsa051600.77777253
66Base excision repair_Homo sapiens_hsa034100.77614885
67p53 signaling pathway_Homo sapiens_hsa041150.77201052
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75658526
69Viral carcinogenesis_Homo sapiens_hsa052030.74452819
70Viral myocarditis_Homo sapiens_hsa054160.74005222
71Vibrio cholerae infection_Homo sapiens_hsa051100.73413541
72Selenocompound metabolism_Homo sapiens_hsa004500.73282043
73Chemokine signaling pathway_Homo sapiens_hsa040620.72582324
74Complement and coagulation cascades_Homo sapiens_hsa046100.72513556
75RNA transport_Homo sapiens_hsa030130.72394806
76Epstein-Barr virus infection_Homo sapiens_hsa051690.72250198
77Galactose metabolism_Homo sapiens_hsa000520.72023798
78Non-homologous end-joining_Homo sapiens_hsa034500.70557369
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70084152
80African trypanosomiasis_Homo sapiens_hsa051430.68771409
81N-Glycan biosynthesis_Homo sapiens_hsa005100.66922142
82Homologous recombination_Homo sapiens_hsa034400.66653866
83Arachidonic acid metabolism_Homo sapiens_hsa005900.65089666
84Small cell lung cancer_Homo sapiens_hsa052220.62953157
85Bladder cancer_Homo sapiens_hsa052190.62379202
86Sulfur metabolism_Homo sapiens_hsa009200.62042065
87Sphingolipid metabolism_Homo sapiens_hsa006000.58440324
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55383078
89Renin-angiotensin system_Homo sapiens_hsa046140.53221099
90Folate biosynthesis_Homo sapiens_hsa007900.53072511
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52413394
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50929862
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50682320
94Prion diseases_Homo sapiens_hsa050200.49160786
95Pancreatic cancer_Homo sapiens_hsa052120.46811782
96Spliceosome_Homo sapiens_hsa030400.45536670
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45530251
98Cell cycle_Homo sapiens_hsa041100.45353089
99Fatty acid elongation_Homo sapiens_hsa000620.45176375
100Chronic myeloid leukemia_Homo sapiens_hsa052200.44983234
101Pyrimidine metabolism_Homo sapiens_hsa002400.44399849
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44201426
103Nucleotide excision repair_Homo sapiens_hsa034200.44090718
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43272785
105Glutathione metabolism_Homo sapiens_hsa004800.42201229
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.40189331
107HTLV-I infection_Homo sapiens_hsa051660.39926610
108RNA degradation_Homo sapiens_hsa030180.39429080
109Protein export_Homo sapiens_hsa030600.39245232
110Systemic lupus erythematosus_Homo sapiens_hsa053220.38800556
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.38285356
112Platelet activation_Homo sapiens_hsa046110.38267305
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37959245
114Sulfur relay system_Homo sapiens_hsa041220.37074860
115HIF-1 signaling pathway_Homo sapiens_hsa040660.33854111
116Amoebiasis_Homo sapiens_hsa051460.33252919
117Endocytosis_Homo sapiens_hsa041440.31472428
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.30991820
119Non-small cell lung cancer_Homo sapiens_hsa052230.30140436
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28382011
121Carbon metabolism_Homo sapiens_hsa012000.27049495

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »