LYSMD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxaloacetate metabolic process (GO:0006107)5.63470718
2NADH metabolic process (GO:0006734)5.14543235
3succinate metabolic process (GO:0006105)4.48074391
4cornea development in camera-type eye (GO:0061303)4.19891864
5regulation of hexokinase activity (GO:1903299)4.19159833
6regulation of glucokinase activity (GO:0033131)4.19159833
72-oxoglutarate metabolic process (GO:0006103)4.07382644
8positive regulation of gamma-delta T cell activation (GO:0046645)3.75575191
9presynaptic membrane assembly (GO:0097105)3.59675281
10tricarboxylic acid cycle (GO:0006099)3.43472463
11protein localization to cilium (GO:0061512)3.42844528
12respiratory chain complex IV assembly (GO:0008535)3.42518033
13keratinocyte development (GO:0003334)3.37252189
14synaptic vesicle exocytosis (GO:0016079)3.33958869
15hindbrain development (GO:0030902)3.31662795
16regulation of synaptic vesicle exocytosis (GO:2000300)3.27639223
17presynaptic membrane organization (GO:0097090)3.27384292
18transferrin transport (GO:0033572)3.25734037
19water-soluble vitamin biosynthetic process (GO:0042364)3.24004095
20pyrimidine nucleobase catabolic process (GO:0006208)3.23936045
21dopamine transport (GO:0015872)3.22953268
22valine metabolic process (GO:0006573)3.20967698
23negative regulation of erythrocyte differentiation (GO:0045647)3.20220100
24glial cell proliferation (GO:0014009)3.16571045
25regulation of gamma-delta T cell differentiation (GO:0045586)3.14776440
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11180803
27negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09725944
28protein K6-linked ubiquitination (GO:0085020)3.07515633
29limb bud formation (GO:0060174)3.06871299
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.06754434
31neurotransmitter-gated ion channel clustering (GO:0072578)3.06489719
32tricarboxylic acid metabolic process (GO:0072350)3.05461031
33ferric iron transport (GO:0015682)3.00890264
34trivalent inorganic cation transport (GO:0072512)3.00890264
35negative regulation of dendrite morphogenesis (GO:0050774)3.00864601
36cytochrome complex assembly (GO:0017004)3.00731969
37coenzyme catabolic process (GO:0009109)3.00589657
38regulation of timing of cell differentiation (GO:0048505)2.97056326
39serine transport (GO:0032329)2.95384710
40L-serine transport (GO:0015825)2.93157397
41cullin deneddylation (GO:0010388)2.88845780
42histone H2A acetylation (GO:0043968)2.88017515
43negative regulation of dendrite development (GO:2000171)2.87855519
44inositol phosphate dephosphorylation (GO:0046855)2.87841076
45phosphorylated carbohydrate dephosphorylation (GO:0046838)2.87841076
46peptidyl-histidine modification (GO:0018202)2.87202969
47ATP hydrolysis coupled proton transport (GO:0015991)2.86678639
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86678639
49intraciliary transport (GO:0042073)2.84756728
50regulation of synaptic vesicle transport (GO:1902803)2.83500393
51ER overload response (GO:0006983)2.82811123
52fucose catabolic process (GO:0019317)2.81721088
53L-fucose metabolic process (GO:0042354)2.81721088
54L-fucose catabolic process (GO:0042355)2.81721088
55L-phenylalanine catabolic process (GO:0006559)2.80084737
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.80084737
57lactate metabolic process (GO:0006089)2.79800463
58glutamate secretion (GO:0014047)2.79078473
59high-density lipoprotein particle remodeling (GO:0034375)2.77229114
60regulation of development, heterochronic (GO:0040034)2.76238960
61behavioral response to nicotine (GO:0035095)2.73612997
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73488628
63inositol phosphate catabolic process (GO:0071545)2.73486846
64ketone body metabolic process (GO:1902224)2.72831094
65regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.72451795
66regulation of acyl-CoA biosynthetic process (GO:0050812)2.71827102
67polyol catabolic process (GO:0046174)2.71739636
68glycosphingolipid biosynthetic process (GO:0006688)2.69673572
69regulation of gamma-delta T cell activation (GO:0046643)2.69551345
70DNA double-strand break processing (GO:0000729)2.68438261
71nucleobase catabolic process (GO:0046113)2.65485178
72NAD metabolic process (GO:0019674)2.64483329
73protein complex biogenesis (GO:0070271)2.64301342
74gamma-aminobutyric acid transport (GO:0015812)2.64224053
75cilium morphogenesis (GO:0060271)2.63702634
76sterol catabolic process (GO:0016127)2.62000667
77cholesterol catabolic process (GO:0006707)2.62000667
78acyl-CoA biosynthetic process (GO:0071616)2.61016092
79thioester biosynthetic process (GO:0035384)2.61016092
80positive regulation of mitochondrial fission (GO:0090141)2.60481529
81protein deneddylation (GO:0000338)2.60466956
82platelet dense granule organization (GO:0060155)2.59819366
83neurotransmitter secretion (GO:0007269)2.59783244
84cellular ketone body metabolic process (GO:0046950)2.59502951
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57663328
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.56729947
87L-phenylalanine metabolic process (GO:0006558)2.56729947
88response to pheromone (GO:0019236)2.56090970
89striatum development (GO:0021756)2.54575026
90lysine catabolic process (GO:0006554)2.53364620
91lysine metabolic process (GO:0006553)2.53364620
92negative regulation of sterol transport (GO:0032372)2.52444931
93negative regulation of cholesterol transport (GO:0032375)2.52444931
94retinal cone cell development (GO:0046549)2.51677524
95positive regulation of actin filament depolymerization (GO:0030836)2.51623753
96dicarboxylic acid catabolic process (GO:0043649)2.50654483
97startle response (GO:0001964)2.50365287
98phagosome maturation (GO:0090382)2.49972567
99aspartate family amino acid catabolic process (GO:0009068)2.49425036
100catecholamine transport (GO:0051937)2.49188344
101dendritic spine morphogenesis (GO:0060997)2.48170160
102creatine metabolic process (GO:0006600)2.48120520
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46211489
104fatty acid elongation (GO:0030497)2.46092169
105regulation of neurotransmitter uptake (GO:0051580)2.45791250
106nonmotile primary cilium assembly (GO:0035058)2.44103406
107positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.43890097
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43875670
109glutamate metabolic process (GO:0006536)2.42716266
110retinal ganglion cell axon guidance (GO:0031290)2.42311084
111cellular modified amino acid catabolic process (GO:0042219)2.41013872
112dopamine biosynthetic process (GO:0042416)2.40950481
113proteasome assembly (GO:0043248)2.40528305
114protein insertion into membrane (GO:0051205)2.39876358
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39728937
116regulation of cofactor metabolic process (GO:0051193)2.39437791
117regulation of coenzyme metabolic process (GO:0051196)2.39437791
118C4-dicarboxylate transport (GO:0015740)2.37717144
119regulation of cilium movement (GO:0003352)2.37587146
120mitochondrial respiratory chain complex assembly (GO:0033108)2.37495692
121establishment of protein localization to mitochondrial membrane (GO:0090151)2.37122241
122behavioral response to ethanol (GO:0048149)2.35240041
123positive regulation of amino acid transport (GO:0051957)2.35112604
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.35073473
125branched-chain amino acid metabolic process (GO:0009081)2.34982494
126mucosal-associated lymphoid tissue development (GO:0048537)2.33370150
127Peyers patch development (GO:0048541)2.33370150
128photoreceptor cell development (GO:0042461)2.32663848
129acetyl-CoA metabolic process (GO:0006084)2.32612423
130positive regulation of B cell differentiation (GO:0045579)2.32263326
131sulfur amino acid catabolic process (GO:0000098)2.31943833
132astrocyte differentiation (GO:0048708)2.31439277
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31331614
134regulation of sulfur metabolic process (GO:0042762)2.30248686
135alpha-linolenic acid metabolic process (GO:0036109)2.29918886
136protein-lipid complex remodeling (GO:0034368)2.29756708
137macromolecular complex remodeling (GO:0034367)2.29756708
138plasma lipoprotein particle remodeling (GO:0034369)2.29756708
139insulin secretion (GO:0030073)2.29528300
140reverse cholesterol transport (GO:0043691)2.28711330
141branched-chain amino acid catabolic process (GO:0009083)2.28426759
142glycerophospholipid catabolic process (GO:0046475)2.27767382
143regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.26503090
144negative regulation of neurological system process (GO:0031645)2.25592381
145neuronal action potential propagation (GO:0019227)2.25415411
146axonal fasciculation (GO:0007413)2.25283533
147regulation of ARF protein signal transduction (GO:0032012)2.25194017
148prenylation (GO:0097354)2.25165818
149protein prenylation (GO:0018342)2.25165818
150branching involved in prostate gland morphogenesis (GO:0060442)2.24880520
151long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.24831552
152positive regulation of TOR signaling (GO:0032008)2.24629835
153cofactor catabolic process (GO:0051187)2.24382030
154neural tube formation (GO:0001841)2.23625572
155dorsal/ventral axis specification (GO:0009950)2.23577877
156inner ear receptor stereocilium organization (GO:0060122)2.23363455
157ethanol oxidation (GO:0006069)2.23311162
158neuron fate determination (GO:0048664)2.22970686
159cholesterol efflux (GO:0033344)2.22828099
160protein-cofactor linkage (GO:0018065)2.22796439
161pancreas development (GO:0031016)2.22756678
162very long-chain fatty acid metabolic process (GO:0000038)2.22707239
163atrial cardiac muscle cell action potential (GO:0086014)2.22681748
164regulation of protein targeting to membrane (GO:0090313)2.22553591
165locomotory exploration behavior (GO:0035641)2.21713589
166regulation of mitochondrial fission (GO:0090140)2.21683674
167low-density lipoprotein particle remodeling (GO:0034374)2.21514819
168negative regulation of protein oligomerization (GO:0032460)2.21026472
169aromatic amino acid family catabolic process (GO:0009074)2.20968120
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.20523843
171negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.19814092
172triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.19499683
173fructose metabolic process (GO:0006000)2.18963701
174neuron cell-cell adhesion (GO:0007158)2.18887517
175prepulse inhibition (GO:0060134)2.17766835
176intracellular pH reduction (GO:0051452)2.17634775
177regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17597606
178regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.17298369
179detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.17224375
180eye photoreceptor cell development (GO:0042462)2.16799649
181preassembly of GPI anchor in ER membrane (GO:0016254)2.15452075
182replication fork processing (GO:0031297)2.15357490
183auditory behavior (GO:0031223)2.14905230
184positive regulation of protein autophosphorylation (GO:0031954)2.14473286
185kidney morphogenesis (GO:0060993)2.13824991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.38174654
2ZNF274_21170338_ChIP-Seq_K562_Hela3.13536361
3FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.12784287
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87147077
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80851040
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76752319
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.75878418
8IGF1R_20145208_ChIP-Seq_DFB_Human2.65554325
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.51684274
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43803191
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41874718
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28885365
13FUS_26573619_Chip-Seq_HEK293_Human2.27156652
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.21304172
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12651725
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09327890
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05943571
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05193556
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04540204
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02082869
21VDR_22108803_ChIP-Seq_LS180_Human2.01669238
22P300_19829295_ChIP-Seq_ESCs_Human2.00954142
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.00185117
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98809769
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.97877387
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96975526
27GATA1_22025678_ChIP-Seq_K562_Human1.96929884
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96517589
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95272557
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.92938999
31EWS_26573619_Chip-Seq_HEK293_Human1.91742969
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89576552
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85717507
34* GATA1_19941827_ChIP-Seq_MEL_Mouse1.81014222
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77991554
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75783780
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.73043716
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72761194
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.71850112
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.71753571
41RUNX_20019798_ChIP-Seq_JUKART_Human1.69033256
42EZH2_22144423_ChIP-Seq_EOC_Human1.68611957
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68058531
44SMAD4_21799915_ChIP-Seq_A2780_Human1.67587857
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.67151776
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61918790
47REST_21632747_ChIP-Seq_MESCs_Mouse1.60936855
48SCL_19346495_ChIP-Seq_HPC-7_Human1.60677406
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.59299849
50ZNF263_19887448_ChIP-Seq_K562_Human1.57084229
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.56372546
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.56241947
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55208222
54ER_23166858_ChIP-Seq_MCF-7_Human1.54044870
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53475657
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53270039
57AR_25329375_ChIP-Seq_VCAP_Human1.51109576
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50891072
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50749338
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49986860
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48685092
62CBP_20019798_ChIP-Seq_JUKART_Human1.48685092
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47471926
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47046070
65ELK1_19687146_ChIP-ChIP_HELA_Human1.46930328
66BCAT_22108803_ChIP-Seq_LS180_Human1.46365757
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45966337
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42718331
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42517112
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41922626
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40435700
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36982017
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36627582
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36623645
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.36144204
76TAF15_26573619_Chip-Seq_HEK293_Human1.35526695
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.35509675
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34932249
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33318712
80* TP53_22573176_ChIP-Seq_HFKS_Human1.32649725
81RNF2_27304074_Chip-Seq_NSC_Mouse1.31926371
82STAT3_23295773_ChIP-Seq_U87_Human1.31578932
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30579972
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.30364009
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29055449
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28972899
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28508842
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28041571
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27643242
90MYC_22102868_ChIP-Seq_BL_Human1.27373253
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26773185
92MYC_18940864_ChIP-ChIP_HL60_Human1.26132363
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24635577
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24071479
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.22106183
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21926190
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21851057
98GATA2_19941826_ChIP-Seq_K562_Human1.21599579
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20895022
100P53_22387025_ChIP-Seq_ESCs_Mouse1.20772506
101TCF4_23295773_ChIP-Seq_U87_Human1.18251022
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16747520
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16701239
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16160301
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15231641
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15209477
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14932856
108TCF4_22108803_ChIP-Seq_LS180_Human1.14804320
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.14387602
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13662750
111RUNX2_22187159_ChIP-Seq_PCA_Human1.13251051
112HTT_18923047_ChIP-ChIP_STHdh_Human1.12193294
113SOX2_19829295_ChIP-Seq_ESCs_Human1.11639743
114NANOG_19829295_ChIP-Seq_ESCs_Human1.11639743
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10425014
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10323561
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10255279
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09251688
119SRF_21415370_ChIP-Seq_HL-1_Mouse1.09204382
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.08517172
121IRF1_19129219_ChIP-ChIP_H3396_Human1.08426230
122GBX2_23144817_ChIP-Seq_PC3_Human1.07992657
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07948744
124KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07755998
125PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07174032
126GATA1_19941826_ChIP-Seq_K562_Human1.06608710
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06414523
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06379266
129MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06129706
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.05895529
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05479637
132* VDR_23849224_ChIP-Seq_CD4+_Human1.04822932
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04049423
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.03517891
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01822846
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01755588
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01729825
138TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01623377
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01462642
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.00771073
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99759767
142* ETS1_20019798_ChIP-Seq_JURKAT_Human0.99489925
143P300_18555785_Chip-Seq_ESCs_Mouse0.98292856
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98142400
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.97879822
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97519709
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97472661
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97367980
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97173434
150JUN_21703547_ChIP-Seq_K562_Human0.97133675
151FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96661647
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94716159
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94665562
154CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92728750
155GATA3_27048872_Chip-Seq_THYMUS_Human0.92179528
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.91830190
157GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88406323
158* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88153417
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87500017
160* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87471775
161NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87296207
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.86816487
163DROSHA_22980978_ChIP-Seq_HELA_Human0.85742459
164SMAD4_21741376_ChIP-Seq_ESCs_Human0.85522353
165* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85216270
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82456797
167SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82075620
168CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80836374
169BCL6_27268052_Chip-Seq_Bcells_Human0.80215860
170EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79322618
171MAF_26560356_Chip-Seq_TH1_Human0.78604730
172* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78230679
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.78053315
174MYB_26560356_Chip-Seq_TH2_Human0.77818410
175GATA3_26560356_Chip-Seq_TH2_Human0.77568342
176PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77179100
177CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.76703702
178GATA3_26560356_Chip-Seq_TH1_Human0.76585593
179CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75035358
180BCOR_27268052_Chip-Seq_Bcells_Human0.74667555
181THAP11_20581084_ChIP-Seq_MESCs_Mouse0.74289822
182KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74007513
183ELF1_20517297_ChIP-Seq_JURKAT_Human0.73399074
184RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70891967
185KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70847168
186SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70037004
187FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69826361
188FOXH1_21741376_ChIP-Seq_ESCs_Human0.69733308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.50091871
2MP0003656_abnormal_erythrocyte_physiolo3.10492330
3MP0003183_abnormal_peptide_metabolism2.88405620
4MP0002102_abnormal_ear_morphology2.86265758
5MP0008877_abnormal_DNA_methylation2.85791187
6MP0001986_abnormal_taste_sensitivity2.64926737
7MP0001984_abnormal_olfaction2.59078478
8MP0002822_catalepsy2.49769667
9MP0002638_abnormal_pupillary_reflex2.48137765
10MP0003122_maternal_imprinting2.44981944
11MP0002938_white_spotting2.44012726
12MP0005360_urolithiasis2.36077334
13MP0008875_abnormal_xenobiotic_pharmacok2.26802255
14MP0004859_abnormal_synaptic_plasticity2.26197263
15MP0003121_genomic_imprinting2.21028659
16MP0006292_abnormal_olfactory_placode2.17733865
17MP0005365_abnormal_bile_salt2.14880884
18MP0003195_calcinosis2.10100258
19MP0004147_increased_porphyrin_level2.07897084
20MP0009046_muscle_twitch2.02497656
21MP0000372_irregular_coat_pigmentation2.00930459
22MP0005310_abnormal_salivary_gland2.00290959
23MP0003635_abnormal_synaptic_transmissio2.00098300
24MP0004043_abnormal_pH_regulation1.98025284
25MP0002064_seizures1.91293260
26MP0000569_abnormal_digit_pigmentation1.87680611
27MP0008789_abnormal_olfactory_epithelium1.87633809
28MP0006072_abnormal_retinal_apoptosis1.84051448
29MP0004130_abnormal_muscle_cell1.80329963
30MP0005253_abnormal_eye_physiology1.78820212
31MP0004270_analgesia1.77020513
32MP0009780_abnormal_chondrocyte_physiolo1.70064747
33MP0003787_abnormal_imprinting1.69960366
34MP0002734_abnormal_mechanical_nocicepti1.68681260
35MP0010234_abnormal_vibrissa_follicle1.62644027
36MP0005647_abnormal_sex_gland1.62441493
37MP0006036_abnormal_mitochondrial_physio1.61987057
38MP0005085_abnormal_gallbladder_physiolo1.60053870
39MP0005551_abnormal_eye_electrophysiolog1.59362518
40MP0010329_abnormal_lipoprotein_level1.58472030
41MP0005187_abnormal_penis_morphology1.58041207
42MP0002736_abnormal_nociception_after1.56772141
43MP0005394_taste/olfaction_phenotype1.52892706
44MP0005499_abnormal_olfactory_system1.52892706
45MP0002909_abnormal_adrenal_gland1.52633662
46MP0001968_abnormal_touch/_nociception1.52391240
47MP0003880_abnormal_central_pattern1.52383072
48MP0002166_altered_tumor_susceptibility1.50923078
49MP0009745_abnormal_behavioral_response1.50010257
50MP0000631_abnormal_neuroendocrine_gland1.49821026
51MP0002272_abnormal_nervous_system1.47627364
52MP0000604_amyloidosis1.46833858
53MP0002751_abnormal_autonomic_nervous1.46480554
54MP0002063_abnormal_learning/memory/cond1.45112765
55MP0005535_abnormal_body_temperature1.43037534
56MP0009840_abnormal_foam_cell1.41589209
57MP0001764_abnormal_homeostasis1.40768311
58MP0002234_abnormal_pharynx_morphology1.40393397
59MP0003329_amyloid_beta_deposits1.38366793
60MP0006035_abnormal_mitochondrial_morpho1.38362689
61MP0005248_abnormal_Harderian_gland1.37402175
62MP0003806_abnormal_nucleotide_metabolis1.37290281
63MP0008569_lethality_at_weaning1.33530233
64MP0000778_abnormal_nervous_system1.33496379
65MP0006276_abnormal_autonomic_nervous1.33485091
66MP0005584_abnormal_enzyme/coenzyme_acti1.32571162
67MP0002735_abnormal_chemical_nociception1.32145177
68MP0004142_abnormal_muscle_tone1.31885381
69MP0002876_abnormal_thyroid_physiology1.31725234
70MP0005646_abnormal_pituitary_gland1.30282655
71MP0001970_abnormal_pain_threshold1.28967116
72MP0005083_abnormal_biliary_tract1.28750389
73MP0002090_abnormal_vision1.28660623
74MP0005058_abnormal_lysosome_morphology1.27333894
75MP0005367_renal/urinary_system_phenotyp1.24223820
76MP0000516_abnormal_urinary_system1.24223820
77MP0005332_abnormal_amino_acid1.23960415
78MP0001765_abnormal_ion_homeostasis1.22910993
79MP0008260_abnormal_autophagy1.21947226
80MP0005464_abnormal_platelet_physiology1.21482774
81MP0002733_abnormal_thermal_nociception1.20443463
82MP0001905_abnormal_dopamine_level1.20136687
83MP0005671_abnormal_response_to1.19651521
84MP0000427_abnormal_hair_cycle1.19603955
85MP0005171_absent_coat_pigmentation1.19444690
86MP0003300_gastrointestinal_ulcer1.18861723
87MP0003866_abnormal_defecation1.18757116
88MP0005636_abnormal_mineral_homeostasis1.17723020
89MP0003283_abnormal_digestive_organ1.17139559
90MP0000647_abnormal_sebaceous_gland1.16978814
91MP0002254_reproductive_system_inflammat1.15321191
92MP0003868_abnormal_feces_composition1.14260149
93MP0002572_abnormal_emotion/affect_behav1.13530689
94MP0004133_heterotaxia1.13235535
95MP0000013_abnormal_adipose_tissue1.12834086
96MP0005075_abnormal_melanosome_morpholog1.12033351
97MP0000685_abnormal_immune_system1.11719997
98MP0008058_abnormal_DNA_repair1.11645841
99MP0009764_decreased_sensitivity_to1.10602071
100MP0002184_abnormal_innervation1.09672863
101MP0001529_abnormal_vocalization1.08523593
102MP0003191_abnormal_cellular_cholesterol1.08511246
103MP0004811_abnormal_neuron_physiology1.06924691
104MP0000609_abnormal_liver_physiology1.05739455
105MP0008995_early_reproductive_senescence1.05477059
106MP0001324_abnormal_eye_pigmentation1.04716086
107MP0001944_abnormal_pancreas_morphology1.04019591
108MP0002067_abnormal_sensory_capabilities1.02819030
109MP0009765_abnormal_xenobiotic_induced1.02814579
110MP0002118_abnormal_lipid_homeostasis1.01350335
111MP0003690_abnormal_glial_cell1.00877485
112MP0003646_muscle_fatigue1.00451499
113MP0000639_abnormal_adrenal_gland1.00167472
114MP0005166_decreased_susceptibility_to0.99861955
115MP0003633_abnormal_nervous_system0.99652659
116MP0001486_abnormal_startle_reflex0.98314785
117MP0008874_decreased_physiological_sensi0.98164809
118MP0002229_neurodegeneration0.97668742
119MP0006082_CNS_inflammation0.96257071
120MP0001666_abnormal_nutrient_absorption0.95135552
121MP0005084_abnormal_gallbladder_morpholo0.93916141
122MP0005379_endocrine/exocrine_gland_phen0.93858332
123MP0003075_altered_response_to0.93111031
124MP0004924_abnormal_behavior0.92834206
125MP0005386_behavior/neurological_phenoty0.92834206
126MP0004858_abnormal_nervous_system0.91804534
127MP0005257_abnormal_intraocular_pressure0.91541078
128MP0002160_abnormal_reproductive_system0.90465080
129MP0003137_abnormal_impulse_conducting0.90082257
130MP0004885_abnormal_endolymph0.90058864
131MP0006054_spinal_hemorrhage0.89028951
132MP0005408_hypopigmentation0.89006874
133MP0002006_tumorigenesis0.88685418
134MP0002837_dystrophic_cardiac_calcinosis0.87638346
135MP0002557_abnormal_social/conspecific_i0.85925439
136MP0001845_abnormal_inflammatory_respons0.85384725
137MP0002163_abnormal_gland_morphology0.85202923
138MP0008057_abnormal_DNA_replication0.84514712
139MP0003879_abnormal_hair_cell0.84464540
140MP0000955_abnormal_spinal_cord0.84118681
141MP0003631_nervous_system_phenotype0.82917049
142MP0001800_abnormal_humoral_immune0.82421498
143MP0005391_vision/eye_phenotype0.82180607
144MP0005319_abnormal_enzyme/_coenzyme0.82115544
145MP0005423_abnormal_somatic_nervous0.81981407
146MP0001501_abnormal_sleep_pattern0.81588587
147MP0000920_abnormal_myelination0.81345664
148MP0002752_abnormal_somatic_nervous0.80985598
149MP0005645_abnormal_hypothalamus_physiol0.80240976
150MP0002928_abnormal_bile_duct0.80185232
151MP0004215_abnormal_myocardial_fiber0.80134753
152MP0003786_premature_aging0.79325926
153MP0003755_abnormal_palate_morphology0.79312017
154MP0000613_abnormal_salivary_gland0.78659164
155MP0008872_abnormal_physiological_respon0.78597077
156MP0002882_abnormal_neuron_morphology0.78392323
157MP0005195_abnormal_posterior_eye0.77974030
158MP0003011_delayed_dark_adaptation0.77799287
159MP0003718_maternal_effect0.77449198
160MP0002723_abnormal_immune_serum0.76652944
161MP0000465_gastrointestinal_hemorrhage0.76338304
162MP0008469_abnormal_protein_level0.74857046
163MP0005387_immune_system_phenotype0.74627541
164MP0001790_abnormal_immune_system0.74627541

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.42937786
2Pheochromocytoma (HP:0002666)3.72594794
3Neuroendocrine neoplasm (HP:0100634)3.47832696
4Myokymia (HP:0002411)3.40370799
5Progressive inability to walk (HP:0002505)3.37600360
6Limb dystonia (HP:0002451)3.36638037
7Abnormal hair whorl (HP:0010721)3.30335718
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.29702189
9Hypoplasia of the fovea (HP:0007750)3.29702189
10Febrile seizures (HP:0002373)3.29069490
11Atonic seizures (HP:0010819)3.22526773
12Medial flaring of the eyebrow (HP:0010747)3.10503851
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.08467835
14Acute necrotizing encephalopathy (HP:0006965)3.06711476
15Sensorimotor neuropathy (HP:0007141)3.03348683
16Intestinal atresia (HP:0011100)3.02428832
17Oligomenorrhea (HP:0000876)2.96467336
18Hyperinsulinemic hypoglycemia (HP:0000825)2.91964099
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91126634
20Hypoglycemic coma (HP:0001325)2.89222844
21Failure to thrive in infancy (HP:0001531)2.88910486
22Neoplasm of the adrenal cortex (HP:0100641)2.84206024
23Abnormality of the fovea (HP:0000493)2.83878217
24Hyperventilation (HP:0002883)2.78860003
25Increased serum pyruvate (HP:0003542)2.78134525
26Abnormality of glycolysis (HP:0004366)2.78134525
27Conjunctival hamartoma (HP:0100780)2.73954999
28Gait imbalance (HP:0002141)2.71687636
29Pancreatic cysts (HP:0001737)2.69177487
30Methylmalonic acidemia (HP:0002912)2.68667308
31True hermaphroditism (HP:0010459)2.68145514
32Epileptic encephalopathy (HP:0200134)2.67828985
33Hypothermia (HP:0002045)2.66621105
34Increased CSF lactate (HP:0002490)2.62461787
35Nephronophthisis (HP:0000090)2.59905012
36Mitochondrial inheritance (HP:0001427)2.59844898
37Pancreatic fibrosis (HP:0100732)2.55881445
38Congenital primary aphakia (HP:0007707)2.54688466
39Ankle clonus (HP:0011448)2.50983863
40Poor suck (HP:0002033)2.49217195
41Abnormality of the labia minora (HP:0012880)2.48928688
42Cholelithiasis (HP:0001081)2.48464211
43Molar tooth sign on MRI (HP:0002419)2.47563765
44Abnormality of midbrain morphology (HP:0002418)2.47563765
45Hemiparesis (HP:0001269)2.47526373
46Hypoglycemic seizures (HP:0002173)2.43935497
47Ragged-red muscle fibers (HP:0003200)2.43267758
48Abnormality of fatty-acid metabolism (HP:0004359)2.42119153
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.42054527
50Delayed gross motor development (HP:0002194)2.41936897
51Nephrogenic diabetes insipidus (HP:0009806)2.41344083
52Acanthocytosis (HP:0001927)2.37273400
53Hyperlipoproteinemia (HP:0010980)2.36501741
54Abnormal gallbladder morphology (HP:0012437)2.36357640
55Status epilepticus (HP:0002133)2.35256033
56Focal seizures (HP:0007359)2.35004908
57Tinnitus (HP:0000360)2.31372513
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30524763
59Generalized hypotonia (HP:0001290)2.28229092
60Ketosis (HP:0001946)2.27461814
61Visual hallucinations (HP:0002367)2.26229005
62Spastic gait (HP:0002064)2.26102298
63Xanthomatosis (HP:0000991)2.25385379
64Neoplasm of the adrenal gland (HP:0100631)2.23761323
65Absence seizures (HP:0002121)2.19756555
66Methylmalonic aciduria (HP:0012120)2.19089259
67Polyphagia (HP:0002591)2.18870811
68Cerebral hemorrhage (HP:0001342)2.18717002
69Prolonged partial thromboplastin time (HP:0003645)2.16975417
70Central scotoma (HP:0000603)2.16455786
71Facial diplegia (HP:0001349)2.16253187
72Genital tract atresia (HP:0001827)2.14668416
73Aplasia/Hypoplasia of the macula (HP:0008059)2.13435489
74Abnormality of the renal cortex (HP:0011035)2.12985212
75Poikilocytosis (HP:0004447)2.09486003
76Optic nerve hypoplasia (HP:0000609)2.09391387
77Spontaneous abortion (HP:0005268)2.08908118
78Impaired vibration sensation in the lower limbs (HP:0002166)2.08596567
79Abnormality of the renal medulla (HP:0100957)2.07430402
80Generalized tonic-clonic seizures (HP:0002069)2.04525788
81Vaginal atresia (HP:0000148)2.03998793
82Renal cortical cysts (HP:0000803)2.02840193
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.02726847
84Abnormality of the metopic suture (HP:0005556)2.00303553
85Lissencephaly (HP:0001339)2.00220571
86Hypobetalipoproteinemia (HP:0003563)1.98938879
87Scanning speech (HP:0002168)1.97373461
88Neoplasm of the peripheral nervous system (HP:0100007)1.97343711
89Increased cerebral lipofuscin (HP:0011813)1.97298112
90Verrucae (HP:0200043)1.96005082
91Papilloma (HP:0012740)1.96005082
92Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95423018
93Deep venous thrombosis (HP:0002625)1.94930093
94Congenital stationary night blindness (HP:0007642)1.94455601
95Inability to walk (HP:0002540)1.94350005
96Supranuclear gaze palsy (HP:0000605)1.93184059
97Increased hepatocellular lipid droplets (HP:0006565)1.90875204
98Depression (HP:0000716)1.90653827
99Gaze-evoked nystagmus (HP:0000640)1.90525173
100Lipid accumulation in hepatocytes (HP:0006561)1.90283686
101Broad-based gait (HP:0002136)1.89443975
102Abnormal mitochondria in muscle tissue (HP:0008316)1.88366912
103Cerebral edema (HP:0002181)1.87900758
104Abnormality of glycine metabolism (HP:0010895)1.87829295
105Abnormality of serine family amino acid metabolism (HP:0010894)1.87829295
106Abnormality of vitamin B metabolism (HP:0004340)1.87351883
107Hyperammonemia (HP:0001987)1.86354386
108Aqueductal stenosis (HP:0002410)1.84157648
109Hepatocellular necrosis (HP:0001404)1.84000539
110Hyperglycinemia (HP:0002154)1.83652459
111Abnormality of pain sensation (HP:0010832)1.82964099
112Impaired pain sensation (HP:0007328)1.82964099
113Abnormality of the gallbladder (HP:0005264)1.82748039
114Abnormality of the pancreatic islet cells (HP:0006476)1.82404321
115Abnormality of endocrine pancreas physiology (HP:0012093)1.82404321
116Ketoacidosis (HP:0001993)1.82218931
117Hyperglycinuria (HP:0003108)1.82139144
118Psychosis (HP:0000709)1.82129978
119Hypomagnesemia (HP:0002917)1.81493276
120Amblyopia (HP:0000646)1.81471093
121Spastic tetraplegia (HP:0002510)1.81176318
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80761873
123Astrocytoma (HP:0009592)1.80638454
124Abnormality of the astrocytes (HP:0100707)1.80638454
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79842929
126Cholecystitis (HP:0001082)1.79182895
127Abnormal gallbladder physiology (HP:0012438)1.79182895
128Intention tremor (HP:0002080)1.78742719
129Elevated erythrocyte sedimentation rate (HP:0003565)1.78522131
130Retinal atrophy (HP:0001105)1.78053755
131Hyperglycemia (HP:0003074)1.77881499
132Epileptiform EEG discharges (HP:0011182)1.77413808
133Muscular hypotonia of the trunk (HP:0008936)1.76954900
134Adrenal hypoplasia (HP:0000835)1.76585950
135Anosmia (HP:0000458)1.75086699
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.74465600
137Dysmetric saccades (HP:0000641)1.74314833
138Acute encephalopathy (HP:0006846)1.74199271
139EEG with generalized epileptiform discharges (HP:0011198)1.73997463
140Abnormal social behavior (HP:0012433)1.73279237
141Impaired social interactions (HP:0000735)1.73279237
142Pendular nystagmus (HP:0012043)1.73260598
143Disproportionate short-trunk short stature (HP:0003521)1.73160127
144Optic disc pallor (HP:0000543)1.73150146
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72921442
146Anxiety (HP:0000739)1.72530316
147Fatigue (HP:0012378)1.72335599
148Dialeptic seizures (HP:0011146)1.71864359
149Hypsarrhythmia (HP:0002521)1.71630651
150Drooling (HP:0002307)1.71285705
151Hemiplegia (HP:0002301)1.71132526
152Truncal ataxia (HP:0002078)1.71066509
153Large for gestational age (HP:0001520)1.71046731
154Brushfield spots (HP:0001088)1.71025553
155Respiratory failure (HP:0002878)1.70946210
156Prominent metopic ridge (HP:0005487)1.70808391
157Aplasia/Hypoplasia of the lens (HP:0008063)1.70300662
158Type II lissencephaly (HP:0007260)1.69501620
159Ependymoma (HP:0002888)1.68851477
160Specific learning disability (HP:0001328)1.68746397
161Thrombocytosis (HP:0001894)1.68034308
162Double outlet right ventricle (HP:0001719)1.67880977
163Congenital malformation of the right heart (HP:0011723)1.67880977
164Hypoplasia of the thymus (HP:0000778)1.67419385
165Abnormality of the intrinsic pathway (HP:0010989)1.67113905
166Exercise-induced myalgia (HP:0003738)1.67083291
167Urinary urgency (HP:0000012)1.67024557
168Hepatic necrosis (HP:0002605)1.66952033
169Glioma (HP:0009733)1.66670360
170Pachygyria (HP:0001302)1.66549521
171Tongue fasciculations (HP:0001308)1.65896367
172Progressive macrocephaly (HP:0004481)1.65842360
173Abolished electroretinogram (ERG) (HP:0000550)1.65362326
174Diminished movement (HP:0002374)1.63573344
175Generalized myoclonic seizures (HP:0002123)1.63158982
176Postaxial hand polydactyly (HP:0001162)1.62595820
177Agitation (HP:0000713)1.61792698
178Narrow forehead (HP:0000341)1.61781280
179Progressive cerebellar ataxia (HP:0002073)1.61477511
180Oligodactyly (hands) (HP:0001180)1.61340903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.28084523
2AKT33.05449161
3MAP4K22.88042363
4MAP3K122.74899261
5WNK32.69326137
6MST42.48180537
7BMPR1B2.42890801
8PDK32.38556435
9PDK42.38556435
10ERN12.37511058
11SGK22.34677597
12CASK2.31992371
13ERBB32.30271388
14SGK32.25819489
15PLK22.25382086
16FRK2.24368630
17SGK4942.16150389
18SGK2232.16150389
19EEF2K2.14616833
20BCR2.06492206
21MAP3K41.98470212
22CSNK1G31.96102231
23TAOK31.93652784
24CSNK1G11.92869253
25CSNK1G21.88421538
26MAP2K71.88181012
27SIK11.83317339
28PINK11.79685016
29DAPK21.73768829
30WEE11.73465124
31CCNB11.73371389
32PAK31.69002108
33BCKDK1.68445491
34DAPK11.65622799
35MAP2K41.63219062
36NUAK11.53041313
37MAP4K11.51976131
38CSNK1A1L1.49869461
39PNCK1.49300206
40GRK11.47281458
41EPHA41.45857459
42CDK191.44794762
43PDK21.44267562
44JAK31.42732268
45INSRR1.40752776
46EIF2AK31.39520595
47TNIK1.36924540
48GRK61.35504418
49TRIB31.34370180
50CAMKK21.30088792
51LMTK21.29742188
52TAOK11.28248536
53FER1.27465458
54DYRK21.26710495
55PHKG21.26572151
56PHKG11.26572151
57SIK31.25577477
58PLK31.24712012
59TXK1.20445236
60PRKCH1.19929149
61PTK2B1.18480009
62MAPKAPK31.17063186
63JAK11.12761548
64SYK1.12680807
65ZAK1.10858239
66LRRK21.07964619
67SRPK11.06325405
68MINK11.06228767
69PRPF4B1.03898062
70RPS6KA21.03817907
71YES10.99020918
72NTRK30.98489492
73EPHA30.95965771
74MAPK120.95862171
75FGFR30.94393543
76TYK20.94191816
77STK390.94142709
78TBK10.93807526
79PRKCE0.92571672
80MKNK20.91277329
81MYLK0.89012301
82MUSK0.86706040
83LIMK10.86647505
84ZAP700.85688030
85LATS10.84398080
86TSSK60.83829805
87NME10.83633783
88RIPK40.83555718
89PDK10.82922851
90PRKD30.82297750
91JAK20.81601996
92FGFR40.81270744
93BUB10.80302143
94MAP3K20.80177195
95IKBKE0.79669544
96ADRBK20.78698603
97OBSCN0.76809267
98EIF2AK10.76219712
99PLK40.75152292
100STK38L0.74871810
101NEK10.74834325
102SIK20.73264124
103EPHB10.72464342
104CAMKK10.72431998
105PIK3CA0.72114674
106ACVR1B0.71631810
107CDK50.70845735
108STK240.67711288
109MAP3K70.67157531
110PDPK10.66754960
111CAMK2A0.66178110
112ROCK20.65237610
113FES0.65171822
114RPS6KB10.65155337
115STK30.62625999
116MAPK130.62612046
117MAP3K140.61277402
118TNK20.59463105
119FLT30.59278689
120PKN10.59061363
121LCK0.58893568
122CAMK2D0.58883948
123FGFR20.58654992
124PRKCI0.58225467
125OXSR10.58035879
126NTRK20.56996855
127MARK10.56639413
128MATK0.55849942
129CSF1R0.55407225
130PRKAA10.54661286
131PAK60.54571283
132NTRK10.53985660
133PRKCG0.53638886
134DAPK30.53350541
135IRAK10.53171916
136CDK30.53069087
137PLK10.52491411
138BRSK20.52480696
139GRK50.52229004
140CSNK1A10.51321270
141MKNK10.51313289
142WNK40.50667071
143VRK10.50554357
144CSNK1D0.49897178
145PKN20.47691953
146RET0.46088795
147IRAK20.45610094
148CAMK2G0.45581943
149PIK3CG0.45554157
150CAMK2B0.45214297
151BRSK10.44647833
152KIT0.44335045
153FYN0.42901898
154MAPKAPK50.41839319
155PTK60.40922409
156DYRK30.40462591
157PRKCQ0.40353173
158SCYL20.39786576
159KSR10.39435629
160BTK0.38982128
161KSR20.38318764
162PRKCZ0.37454521
163HIPK20.37016104
164ADRBK10.35085762
165ATM0.34200899
166STK160.32452045
167DYRK1A0.31540312
168RPS6KA50.31420075
169PRKACA0.31195821
170PRKACB0.30954033

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44499339
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.37599724
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.33498147
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.14803052
5Protein export_Homo sapiens_hsa030603.05799403
6Synaptic vesicle cycle_Homo sapiens_hsa047213.02377223
7Collecting duct acid secretion_Homo sapiens_hsa049662.75063835
8Sulfur metabolism_Homo sapiens_hsa009202.27232058
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26652251
10Pyruvate metabolism_Homo sapiens_hsa006202.21830591
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17250610
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07094779
13Vitamin B6 metabolism_Homo sapiens_hsa007502.01095453
14Propanoate metabolism_Homo sapiens_hsa006401.96340711
15Olfactory transduction_Homo sapiens_hsa047401.95170154
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89735281
17Non-homologous end-joining_Homo sapiens_hsa034501.78649909
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78461562
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.71834685
20Arginine biosynthesis_Homo sapiens_hsa002201.70655376
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70548323
22Fanconi anemia pathway_Homo sapiens_hsa034601.61184870
23Vibrio cholerae infection_Homo sapiens_hsa051101.54254573
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51254161
25Steroid biosynthesis_Homo sapiens_hsa001001.49506325
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42972864
27Fatty acid degradation_Homo sapiens_hsa000711.42059043
28Butanoate metabolism_Homo sapiens_hsa006501.41656514
29Phototransduction_Homo sapiens_hsa047441.41541178
30Basal transcription factors_Homo sapiens_hsa030221.40387704
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37829435
32Carbon metabolism_Homo sapiens_hsa012001.36212531
33Folate biosynthesis_Homo sapiens_hsa007901.35630767
34Fatty acid elongation_Homo sapiens_hsa000621.33507540
35Proteasome_Homo sapiens_hsa030501.31715982
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21467827
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21245660
38Fatty acid metabolism_Homo sapiens_hsa012121.20116929
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18909431
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.14393838
41GABAergic synapse_Homo sapiens_hsa047271.13643797
42Huntingtons disease_Homo sapiens_hsa050161.11404548
43Peroxisome_Homo sapiens_hsa041461.10546803
44Biosynthesis of amino acids_Homo sapiens_hsa012301.09466249
45Cardiac muscle contraction_Homo sapiens_hsa042601.07166168
46Oxidative phosphorylation_Homo sapiens_hsa001901.06386642
47RNA polymerase_Homo sapiens_hsa030201.04027518
48Homologous recombination_Homo sapiens_hsa034401.03184467
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00940591
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98823472
51RNA degradation_Homo sapiens_hsa030180.97403967
52Dopaminergic synapse_Homo sapiens_hsa047280.96997012
53Circadian rhythm_Homo sapiens_hsa047100.95540570
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92464869
55Rheumatoid arthritis_Homo sapiens_hsa053230.89738593
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89482379
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89404122
58Oocyte meiosis_Homo sapiens_hsa041140.88921816
59Circadian entrainment_Homo sapiens_hsa047130.87349782
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85015931
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81381669
62Morphine addiction_Homo sapiens_hsa050320.81183075
63Ether lipid metabolism_Homo sapiens_hsa005650.80956142
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80423693
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80103826
66Sulfur relay system_Homo sapiens_hsa041220.78244242
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76646899
68Nicotine addiction_Homo sapiens_hsa050330.74507038
69Taste transduction_Homo sapiens_hsa047420.73024105
70Tryptophan metabolism_Homo sapiens_hsa003800.72289502
71Metabolic pathways_Homo sapiens_hsa011000.71368118
72Insulin resistance_Homo sapiens_hsa049310.70287416
73Selenocompound metabolism_Homo sapiens_hsa004500.70042108
74ABC transporters_Homo sapiens_hsa020100.69967585
75Cholinergic synapse_Homo sapiens_hsa047250.68731743
76Long-term potentiation_Homo sapiens_hsa047200.66111405
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66022053
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65577777
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.65063398
80Fructose and mannose metabolism_Homo sapiens_hsa000510.63826893
81Glutamatergic synapse_Homo sapiens_hsa047240.63124126
82Base excision repair_Homo sapiens_hsa034100.62830576
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61593130
84PPAR signaling pathway_Homo sapiens_hsa033200.61564550
85Purine metabolism_Homo sapiens_hsa002300.60213968
86Hedgehog signaling pathway_Homo sapiens_hsa043400.58395839
87Bile secretion_Homo sapiens_hsa049760.58131857
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57351965
89Phagosome_Homo sapiens_hsa041450.55609215
90Nitrogen metabolism_Homo sapiens_hsa009100.54929748
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54708917
92Prolactin signaling pathway_Homo sapiens_hsa049170.54567213
93Pentose phosphate pathway_Homo sapiens_hsa000300.54062650
94Glucagon signaling pathway_Homo sapiens_hsa049220.54026951
95Mismatch repair_Homo sapiens_hsa034300.53556454
96Glutathione metabolism_Homo sapiens_hsa004800.52817385
97Insulin secretion_Homo sapiens_hsa049110.52804329
98Pyrimidine metabolism_Homo sapiens_hsa002400.52151646
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51127708
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51032036
101Amphetamine addiction_Homo sapiens_hsa050310.50986322
102Inositol phosphate metabolism_Homo sapiens_hsa005620.50887476
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50514952
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.49680601
105Primary immunodeficiency_Homo sapiens_hsa053400.49272581
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49167782
107Nucleotide excision repair_Homo sapiens_hsa034200.48861540
108Linoleic acid metabolism_Homo sapiens_hsa005910.48482452
109Parkinsons disease_Homo sapiens_hsa050120.47372068
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47293572
111Lysine degradation_Homo sapiens_hsa003100.46720069
112Cocaine addiction_Homo sapiens_hsa050300.46167298
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45694729
114RNA transport_Homo sapiens_hsa030130.45395537
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44912310
116Alzheimers disease_Homo sapiens_hsa050100.44896645
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44816305
118Hepatitis C_Homo sapiens_hsa051600.44735525
119Long-term depression_Homo sapiens_hsa047300.44361312
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44263354
121Renin secretion_Homo sapiens_hsa049240.44258861
122Salivary secretion_Homo sapiens_hsa049700.43097912
123Insulin signaling pathway_Homo sapiens_hsa049100.41604221
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.41377013
125N-Glycan biosynthesis_Homo sapiens_hsa005100.41053120
126ErbB signaling pathway_Homo sapiens_hsa040120.41048444
127Arginine and proline metabolism_Homo sapiens_hsa003300.40915049
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40293194
129Regulation of autophagy_Homo sapiens_hsa041400.39815707
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39367928
131Ovarian steroidogenesis_Homo sapiens_hsa049130.38429598
132Chemical carcinogenesis_Homo sapiens_hsa052040.38417344
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37928056
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37649858
135T cell receptor signaling pathway_Homo sapiens_hsa046600.36884855
136Serotonergic synapse_Homo sapiens_hsa047260.35726853
137Complement and coagulation cascades_Homo sapiens_hsa046100.34738034
138B cell receptor signaling pathway_Homo sapiens_hsa046620.34454851
139beta-Alanine metabolism_Homo sapiens_hsa004100.34305558
140Acute myeloid leukemia_Homo sapiens_hsa052210.34243675
141Legionellosis_Homo sapiens_hsa051340.34110324
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33365907
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33202418
144Endometrial cancer_Homo sapiens_hsa052130.32999690
145Non-small cell lung cancer_Homo sapiens_hsa052230.31858694

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