LYPLA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.42044311
2Arp2/3 complex-mediated actin nucleation (GO:0034314)6.08673471
3cytidine deamination (GO:0009972)6.08487519
4cytidine metabolic process (GO:0046087)6.08487519
5cytidine catabolic process (GO:0006216)6.08487519
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.29207281
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.14896868
8actin nucleation (GO:0045010)5.07507369
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.59322954
10monocyte chemotaxis (GO:0002548)4.39585115
11proteasome assembly (GO:0043248)4.29944412
12negative regulation of T cell apoptotic process (GO:0070233)4.28450555
13positive regulation of B cell differentiation (GO:0045579)4.26617339
14regulation of regulatory T cell differentiation (GO:0045589)4.06300718
15protein deneddylation (GO:0000338)3.82368908
16protein kinase C signaling (GO:0070528)3.80361449
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.79689344
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.79265682
19positive regulation of natural killer cell mediated immunity (GO:0002717)3.77796436
20cullin deneddylation (GO:0010388)3.77193678
21positive thymic T cell selection (GO:0045059)3.73822249
22platelet dense granule organization (GO:0060155)3.67882935
23positive regulation of tolerance induction (GO:0002645)3.63744754
24regulation of activation of Janus kinase activity (GO:0010533)3.60102761
25regulation of B cell receptor signaling pathway (GO:0050855)3.48017342
26positive T cell selection (GO:0043368)3.47595191
27B cell mediated immunity (GO:0019724)3.45789577
28regulation of T cell tolerance induction (GO:0002664)3.44574397
29deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.43815129
30macrophage chemotaxis (GO:0048246)3.42850663
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42451886
32aggressive behavior (GO:0002118)3.41539494
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38615485
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35363376
35regulation of cellular amino acid metabolic process (GO:0006521)3.35267610
36water-soluble vitamin biosynthetic process (GO:0042364)3.34999926
37negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32489817
38deoxyribose phosphate biosynthetic process (GO:0046385)3.32320381
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.32320381
40immunoglobulin mediated immune response (GO:0016064)3.29881651
41purine deoxyribonucleotide catabolic process (GO:0009155)3.27150989
42negative regulation of lymphocyte apoptotic process (GO:0070229)3.20824745
43cytolysis (GO:0019835)3.20490361
44deoxyribose phosphate catabolic process (GO:0046386)3.15471786
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14994117
46branched-chain amino acid catabolic process (GO:0009083)3.14016286
47pyrimidine nucleoside catabolic process (GO:0046135)3.12108027
48purine deoxyribonucleotide metabolic process (GO:0009151)3.11928171
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10944078
50regulation of tolerance induction (GO:0002643)3.09150304
51rRNA modification (GO:0000154)3.06499906
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06438602
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06438602
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06438602
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06314570
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06314570
57deoxyribonucleotide catabolic process (GO:0009264)3.05618381
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03415806
59negative regulation of ligase activity (GO:0051352)3.03415806
60response to interferon-beta (GO:0035456)3.02310848
61chaperone mediated protein folding requiring cofactor (GO:0051085)3.01708768
62hyperosmotic salinity response (GO:0042538)3.01423487
63regulation of natural killer cell mediated immunity (GO:0002715)2.99254638
64regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99254638
65purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.96321397
66regulation of T cell apoptotic process (GO:0070232)2.95832728
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.95561451
68signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95561451
69regulation of interleukin-2 biosynthetic process (GO:0045076)2.93402941
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92725243
71mitochondrial calcium ion transport (GO:0006851)2.92341802
72purine-containing compound salvage (GO:0043101)2.90537632
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90391040
742-deoxyribonucleotide metabolic process (GO:0009394)2.90190847
75signal transduction involved in cell cycle checkpoint (GO:0072395)2.89844815
76eosinophil chemotaxis (GO:0048245)2.89463017
77regulation of B cell differentiation (GO:0045577)2.89348206
78regulation of mitochondrial translation (GO:0070129)2.87695396
79facial nerve structural organization (GO:0021612)2.87583039
80cellular response to interleukin-15 (GO:0071350)2.86720585
81antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84224986
82deoxyribose phosphate metabolic process (GO:0019692)2.81468532
83pyrimidine ribonucleoside metabolic process (GO:0046131)2.80356908
84cellular ketone body metabolic process (GO:0046950)2.80095801
85regulation of penile erection (GO:0060405)2.79633345
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75897786
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73334348
88sequestering of actin monomers (GO:0042989)2.72892164
89metallo-sulfur cluster assembly (GO:0031163)2.71362620
90iron-sulfur cluster assembly (GO:0016226)2.71362620
91positive regulation of monocyte chemotaxis (GO:0090026)2.69787467
92pyrimidine nucleotide catabolic process (GO:0006244)2.68021788
93pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.67659882
94artery smooth muscle contraction (GO:0014824)2.67417674
95negative T cell selection (GO:0043383)2.67160061
96ribosomal small subunit assembly (GO:0000028)2.66824429
97purine nucleotide salvage (GO:0032261)2.65500184
98mast cell activation involved in immune response (GO:0002279)2.64737706
99mast cell degranulation (GO:0043303)2.64737706
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63437218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.46368157
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.16955664
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.09952043
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.93331905
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63195280
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43493570
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.38625884
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32788708
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15942414
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.96521107
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.79961898
12VDR_23849224_ChIP-Seq_CD4+_Human2.63275855
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.53300965
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.51082284
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44698097
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39181628
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38148097
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34219956
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30438286
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28983401
21FOXP3_21729870_ChIP-Seq_TREG_Human2.22351123
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.17774982
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17210446
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12249948
25IGF1R_20145208_ChIP-Seq_DFB_Human2.09076440
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07151832
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06744321
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04267175
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98202666
30MYB_26560356_Chip-Seq_TH2_Human1.89808019
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.89754832
32ELK1_19687146_ChIP-ChIP_HELA_Human1.86738301
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83324701
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78147734
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76176151
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72636102
37E2F7_22180533_ChIP-Seq_HELA_Human1.68311276
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67274762
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.61156730
40ZNF274_21170338_ChIP-Seq_K562_Hela1.60909764
41GABP_19822575_ChIP-Seq_HepG2_Human1.60705523
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50875274
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50807436
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49542962
45GATA1_22025678_ChIP-Seq_K562_Human1.47768464
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.46279717
47CIITA_25753668_ChIP-Seq_RAJI_Human1.46084168
48SPI1_23547873_ChIP-Seq_NB4_Human1.44201435
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40285088
50UTX_26944678_Chip-Seq_JUKART_Human1.40091037
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38281597
52MYC_18940864_ChIP-ChIP_HL60_Human1.37180867
53VDR_22108803_ChIP-Seq_LS180_Human1.34690337
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33308707
55GATA3_27048872_Chip-Seq_THYMUS_Human1.32344804
56DCP1A_22483619_ChIP-Seq_HELA_Human1.31746335
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.31494326
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29666807
59MYB_26560356_Chip-Seq_TH1_Human1.28665175
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26432631
61HTT_18923047_ChIP-ChIP_STHdh_Human1.23900027
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21649875
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21121422
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19652885
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19312510
66RUNX_20019798_ChIP-Seq_JUKART_Human1.18278158
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16342374
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14796737
69SPI1_20517297_ChIP-Seq_HL60_Human1.13694413
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11857796
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11277443
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11163830
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10851381
74GATA3_26560356_Chip-Seq_TH2_Human1.08653732
75BCL6_27268052_Chip-Seq_Bcells_Human1.08035850
76TAF2_19829295_ChIP-Seq_ESCs_Human1.07383736
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05775958
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04905663
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01847173
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99277264
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99237788
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99003449
83XRN2_22483619_ChIP-Seq_HELA_Human0.98864280
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96014457
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95404953
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95290871
87NANOG_20526341_ChIP-Seq_ESCs_Human0.94493052
88P300_27268052_Chip-Seq_Bcells_Human0.94369633
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93238166
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.92547791
91MAF_26560356_Chip-Seq_TH1_Human0.90728227
92AR_20517297_ChIP-Seq_VCAP_Human0.90542277
93MAF_26560356_Chip-Seq_TH2_Human0.90412124
94IRF1_19129219_ChIP-ChIP_H3396_Human0.89940496
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.89439343
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87253665
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.86618997
98TP53_22573176_ChIP-Seq_HFKS_Human0.82553162
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80462430
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77693666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.61619961
2MP0001873_stomach_inflammation3.56746507
3MP0005645_abnormal_hypothalamus_physiol3.43730590
4MP0002166_altered_tumor_susceptibility3.12473908
5MP0002009_preneoplasia2.77710615
6MP0001835_abnormal_antigen_presentation2.77689905
7MP0002006_tumorigenesis2.60256970
8MP0009697_abnormal_copulation2.43920419
9MP0003763_abnormal_thymus_physiology2.33509186
10MP0009785_altered_susceptibility_to2.29331549
11MP0006072_abnormal_retinal_apoptosis2.22345891
12MP0002138_abnormal_hepatobiliary_system2.15138587
13MP0001905_abnormal_dopamine_level2.03533818
14MP0005000_abnormal_immune_tolerance1.94351481
15MP0005025_abnormal_response_to1.91820769
16MP0002420_abnormal_adaptive_immunity1.89741320
17MP0005646_abnormal_pituitary_gland1.89315215
18MP0003866_abnormal_defecation1.88992182
19MP0009764_decreased_sensitivity_to1.88622494
20MP0006082_CNS_inflammation1.85829447
21MP0001800_abnormal_humoral_immune1.84777403
22MP0002933_joint_inflammation1.83639495
23MP0001819_abnormal_immune_cell1.83117646
24MP0002723_abnormal_immune_serum1.82734843
25MP0003011_delayed_dark_adaptation1.82265124
26MP0005387_immune_system_phenotype1.77856308
27MP0001790_abnormal_immune_system1.77856308
28MP0002638_abnormal_pupillary_reflex1.77684852
29MP0005075_abnormal_melanosome_morpholog1.76580359
30MP0005167_abnormal_blood-brain_barrier1.72689924
31MP0006035_abnormal_mitochondrial_morpho1.70950852
32MP0008058_abnormal_DNA_repair1.70119755
33MP0006036_abnormal_mitochondrial_physio1.61687622
34MP0010094_abnormal_chromosome_stability1.61104418
35MP0000372_irregular_coat_pigmentation1.61065270
36MP0002405_respiratory_system_inflammati1.58725540
37MP0000689_abnormal_spleen_morphology1.58689439
38MP0002452_abnormal_antigen_presenting1.53511788
39MP0002398_abnormal_bone_marrow1.53211350
40MP0002148_abnormal_hypersensitivity_rea1.52712098
41MP0003806_abnormal_nucleotide_metabolis1.51467503
42MP0003786_premature_aging1.50154680
43MP0004782_abnormal_surfactant_physiolog1.48436990
44MP0000716_abnormal_immune_system1.45201172
45MP0001853_heart_inflammation1.42050431
46MP0002722_abnormal_immune_system1.41091938
47MP0003567_abnormal_fetal_cardiomyocyte1.39649789
48MP0003724_increased_susceptibility_to1.38393196
49MP0000465_gastrointestinal_hemorrhage1.37398477
50MP0010155_abnormal_intestine_physiology1.36677460
51MP0005253_abnormal_eye_physiology1.35304533
52MP0000703_abnormal_thymus_morphology1.34700081
53MP0002429_abnormal_blood_cell1.28728833
54MP0008007_abnormal_cellular_replicative1.27029269
55MP0005464_abnormal_platelet_physiology1.24667714
56MP0002277_abnormal_respiratory_mucosa1.20705976
57MP0003693_abnormal_embryo_hatching1.18676495
58MP0002653_abnormal_ependyma_morphology1.12763991
59MP0000685_abnormal_immune_system1.11924072
60MP0001845_abnormal_inflammatory_respons1.11795025
61MP0003136_yellow_coat_color1.07299231
62MP0002419_abnormal_innate_immunity1.06316795
63MP0002019_abnormal_tumor_incidence1.05820915
64MP0002163_abnormal_gland_morphology1.01684693
65MP0002877_abnormal_melanocyte_morpholog1.00069941
66MP0008872_abnormal_physiological_respon0.99551498
67MP0009763_increased_sensitivity_to0.97531543
68MP0002102_abnormal_ear_morphology0.96152932
69MP0003436_decreased_susceptibility_to0.95570777
70MP0003075_altered_response_to0.93941107
71MP0001663_abnormal_digestive_system0.92670493
72MP0005379_endocrine/exocrine_gland_phen0.92561775
73MP0003448_altered_tumor_morphology0.89402309
74MP0008260_abnormal_autophagy0.89175394
75MP0001764_abnormal_homeostasis0.86607772
76MP0004957_abnormal_blastocyst_morpholog0.86415641
77MP0009333_abnormal_splenocyte_physiolog0.86341502
78MP0000490_abnormal_crypts_of0.84984420
79MP0008469_abnormal_protein_level0.82779660
80MP0000613_abnormal_salivary_gland0.82624787
81MP0003191_abnormal_cellular_cholesterol0.79621250
82MP0005319_abnormal_enzyme/_coenzyme0.79169632
83MP0002095_abnormal_skin_pigmentation0.76915856
84MP0005220_abnormal_exocrine_pancreas0.76126380
85MP0002139_abnormal_hepatobiliary_system0.74700962
86MP0003186_abnormal_redox_activity0.74139380
87MP0008875_abnormal_xenobiotic_pharmacok0.73422649
88MP0008873_increased_physiological_sensi0.73291176
89MP0005551_abnormal_eye_electrophysiolog0.72309968
90MP0002132_abnormal_respiratory_system0.66922776
91MP0010368_abnormal_lymphatic_system0.65098461
92MP0003718_maternal_effect0.63721441
93MP0005332_abnormal_amino_acid0.63333137
94MP0000358_abnormal_cell_content/0.62621921
95MP0005647_abnormal_sex_gland0.61714149
96MP0001545_abnormal_hematopoietic_system0.61031072
97MP0005397_hematopoietic_system_phenotyp0.61031072
98MP0005410_abnormal_fertilization0.60462239
99MP0002693_abnormal_pancreas_physiology0.60441949
100MP0005535_abnormal_body_temperature0.58909601

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.76839988
2Aplastic anemia (HP:0001915)5.74787361
3Hepatocellular necrosis (HP:0001404)4.70637800
4Type I transferrin isoform profile (HP:0003642)4.37658496
5Microvesicular hepatic steatosis (HP:0001414)4.28929899
6Hepatic necrosis (HP:0002605)4.11502592
7Chronic mucocutaneous candidiasis (HP:0002728)4.00067880
8Recurrent cutaneous fungal infections (HP:0011370)4.00067880
9T lymphocytopenia (HP:0005403)3.91017858
10Increased hepatocellular lipid droplets (HP:0006565)3.83887595
11Panhypogammaglobulinemia (HP:0003139)3.83455242
12Autoimmune hemolytic anemia (HP:0001890)3.79780170
13Severe combined immunodeficiency (HP:0004430)3.77278640
14Agammaglobulinemia (HP:0004432)3.74977552
15Mitochondrial inheritance (HP:0001427)3.65915458
16Abnormality of T cell number (HP:0011839)3.57838530
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.54892367
18Abnormal glycosylation (HP:0012345)3.52177256
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.52177256
20Abnormal protein N-linked glycosylation (HP:0012347)3.52177256
21Abnormal protein glycosylation (HP:0012346)3.52177256
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.50191012
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.50191012
24Encephalitis (HP:0002383)3.45428221
25Lipid accumulation in hepatocytes (HP:0006561)3.36533878
263-Methylglutaconic aciduria (HP:0003535)3.33221938
27Abnormality of T cells (HP:0002843)3.30506245
28Increased IgM level (HP:0003496)3.20551869
29Increased CSF lactate (HP:0002490)3.11026438
30Recurrent viral infections (HP:0004429)3.11000312
31Increased intramyocellular lipid droplets (HP:0012240)3.09249717
32Renal Fanconi syndrome (HP:0001994)3.02736712
33Prolonged neonatal jaundice (HP:0006579)3.01373369
34Combined immunodeficiency (HP:0005387)3.01106898
35Pancytopenia (HP:0001876)2.99031489
36Autoimmune thrombocytopenia (HP:0001973)2.87372634
37Abnormality of T cell physiology (HP:0011840)2.84854746
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83148370
39IgG deficiency (HP:0004315)2.81804020
40Acute hepatic failure (HP:0006554)2.81593187
41Acute necrotizing encephalopathy (HP:0006965)2.69865820
42Dicarboxylic aciduria (HP:0003215)2.69548746
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69548746
44Abnormal mitochondria in muscle tissue (HP:0008316)2.69164536
45Stomach cancer (HP:0012126)2.65895493
46Thyroiditis (HP:0100646)2.65368413
47Increased serum lactate (HP:0002151)2.61323246
48Dyschromatopsia (HP:0007641)2.57074121
49Oral leukoplakia (HP:0002745)2.55787069
50Increased muscle lipid content (HP:0009058)2.52465812
51Abnormality of the prostate (HP:0008775)2.52437030
52Abnormality of B cell number (HP:0010975)2.51277068
53Amyotrophic lateral sclerosis (HP:0007354)2.48719689
54Progressive macrocephaly (HP:0004481)2.45359209
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40202634
56Lactic acidosis (HP:0003128)2.39057777
57B lymphocytopenia (HP:0010976)2.34570104
58CNS demyelination (HP:0007305)2.32148366
59Abnormality of renal resorption (HP:0011038)2.31882107
60Exertional dyspnea (HP:0002875)2.31593357
61Hypoproteinemia (HP:0003075)2.31079207
62Recurrent fungal infections (HP:0002841)2.28318437
63Myositis (HP:0100614)2.27888954
64Hypergammaglobulinemia (HP:0010702)2.24682164
65Meningitis (HP:0001287)2.21040284
66Methylmalonic aciduria (HP:0012120)2.20734016
67Acute encephalopathy (HP:0006846)2.19332227
68Cerebral edema (HP:0002181)2.17182653
69Thrombocytosis (HP:0001894)2.15900633
70Cellular immunodeficiency (HP:0005374)2.14248435
71Reduced antithrombin III activity (HP:0001976)2.14231837
72Chronic diarrhea (HP:0002028)2.13238187
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.10629852
74Abnormality of midbrain morphology (HP:0002418)2.05805428
75Molar tooth sign on MRI (HP:0002419)2.05805428
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04299838
77Abolished electroretinogram (ERG) (HP:0000550)2.04068787
78Hypoplasia of the thymus (HP:0000778)2.03752526
79Petechiae (HP:0000967)2.02929136
80Lymphoma (HP:0002665)2.01902101
81Recurrent skin infections (HP:0001581)2.00547594
82Emotional lability (HP:0000712)1.98568577
83Hemiplegia (HP:0002301)1.95346620
84Ketosis (HP:0001946)1.94104243
85Cutaneous melanoma (HP:0012056)1.92155220
86Short tibia (HP:0005736)1.88057810
87Respiratory failure (HP:0002878)1.86621509
88Large eyes (HP:0001090)1.83775715
89Abnormal rod and cone electroretinograms (HP:0008323)1.82854914
90Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80531522
91Colitis (HP:0002583)1.79673419
92Villous atrophy (HP:0011473)1.78045284
93Abnormality of small intestinal villus morphology (HP:0011472)1.78045284
94Abnormality of fatty-acid metabolism (HP:0004359)1.74938050
95Abnormality of lateral ventricle (HP:0030047)1.74136046
96Alveolar cell carcinoma (HP:0006519)1.72830124
97Generalized aminoaciduria (HP:0002909)1.72321007
98Lymphopenia (HP:0001888)1.71321063
99Optic disc pallor (HP:0000543)1.71240432
100IgM deficiency (HP:0002850)1.69325959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.44644211
2KDR4.83933475
3TXK4.43629449
4TESK23.16822378
5ZAK2.85573134
6SCYL22.77504359
7MST42.60124573
8VRK22.56212807
9BCKDK2.38282602
10FES2.31768291
11GRK11.89120226
12MAP4K21.88507244
13TESK11.87985002
14TLK11.87253620
15TEC1.86572410
16NME21.82713414
17VRK11.81061673
18TBK11.75633837
19MAPKAPK31.72134405
20DAPK11.64737727
21LIMK11.62478409
22BMPR1B1.60557224
23CDK81.48357770
24CDC71.27196505
25ERBB31.22747977
26MAP4K11.22477106
27MAP3K121.19806001
28MAP2K61.13859787
29TNK21.13721860
30CDK191.06361719
31BLK1.05051067
32PIK3CG1.02906232
33MAP2K70.99990322
34SYK0.99922549
35ADRBK20.97911679
36MAP3K40.96456266
37BUB10.96346930
38PRKCQ0.96273042
39FRK0.94071028
40BTK0.93927415
41BMPR20.93148892
42CDK90.93128872
43NUAK10.91538450
44TAOK30.88135314
45IKBKB0.87342807
46MAP2K30.85088415
47PBK0.83433146
48KIT0.82581088
49LCK0.82439406
50ZAP700.81129154
51ITK0.76988279
52LYN0.76724146
53GRK60.76526213
54MAP3K50.74291430
55IKBKE0.74120376
56PIM10.69201381
57CSNK1G30.65448459
58RIPK40.63674844
59PIM20.63607215
60SRPK10.61579932
61AURKA0.59815882
62CSK0.59663429
63TRIM280.54174123
64MYLK0.53917866
65EIF2AK10.53767115
66RPS6KA40.52305749
67RPS6KA50.52078430
68ATR0.51360629
69CSF1R0.50282410
70ACVR1B0.49599192
71MAP3K100.49521296
72MAP2K40.47816304
73TGFBR20.46479405
74EPHA40.46475636
75TGFBR10.45341881
76MAP3K110.44252996
77PTK2B0.43849231
78CSNK1G10.43074582
79INSRR0.43036709
80CSNK1A1L0.42211156
81DAPK30.40771334
82WNK30.40449577
83TAOK10.39184908
84HCK0.38054911
85FYN0.36416326
86ABL10.33297804
87CSNK1G20.32424149
88OXSR10.32095059
89DYRK1B0.31804370
90IRAK40.31277067
91CSNK2A10.29853122
92PINK10.29485443
93AURKB0.29392347
94ROCK10.29119908
95CDK40.29082605
96CDK70.28160259
97EIF2AK30.28114297
98ABL20.27776186
99CHEK20.27037386
100TAF10.26586360

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.66587980
2Primary immunodeficiency_Homo sapiens_hsa053404.52680576
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.22908216
4Autoimmune thyroid disease_Homo sapiens_hsa053202.51773564
5Antigen processing and presentation_Homo sapiens_hsa046122.43727499
6Graft-versus-host disease_Homo sapiens_hsa053322.42674270
7Oxidative phosphorylation_Homo sapiens_hsa001902.42665796
8Parkinsons disease_Homo sapiens_hsa050122.30256535
9Allograft rejection_Homo sapiens_hsa053302.24336559
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16663083
11Sulfur relay system_Homo sapiens_hsa041222.11508863
12Protein export_Homo sapiens_hsa030602.00135954
13Propanoate metabolism_Homo sapiens_hsa006401.98088772
14Type I diabetes mellitus_Homo sapiens_hsa049401.94387734
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92603325
16RNA polymerase_Homo sapiens_hsa030201.81589347
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.63336224
18Hematopoietic cell lineage_Homo sapiens_hsa046401.57790494
19Pyrimidine metabolism_Homo sapiens_hsa002401.49262450
20Peroxisome_Homo sapiens_hsa041461.39570474
21T cell receptor signaling pathway_Homo sapiens_hsa046601.38916795
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38292858
23Ribosome_Homo sapiens_hsa030101.35977991
24DNA replication_Homo sapiens_hsa030301.35353993
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31729750
26Huntingtons disease_Homo sapiens_hsa050161.29744075
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25811131
28Asthma_Homo sapiens_hsa053101.24574260
29Rheumatoid arthritis_Homo sapiens_hsa053231.22438599
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20256055
31Butanoate metabolism_Homo sapiens_hsa006501.16384158
32Fanconi anemia pathway_Homo sapiens_hsa034601.16231584
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15729626
34Shigellosis_Homo sapiens_hsa051311.13894282
35Alzheimers disease_Homo sapiens_hsa050101.12571268
36Regulation of autophagy_Homo sapiens_hsa041401.11261185
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10979289
38N-Glycan biosynthesis_Homo sapiens_hsa005101.09109395
39Viral myocarditis_Homo sapiens_hsa054161.07221860
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06532646
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02823388
42Homologous recombination_Homo sapiens_hsa034401.02615243
43Folate biosynthesis_Homo sapiens_hsa007900.99146317
44Mismatch repair_Homo sapiens_hsa034300.97435672
45Sulfur metabolism_Homo sapiens_hsa009200.96626241
46Base excision repair_Homo sapiens_hsa034100.95331245
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93677603
48Purine metabolism_Homo sapiens_hsa002300.91270061
49Systemic lupus erythematosus_Homo sapiens_hsa053220.89110482
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88278948
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87215952
52Vitamin B6 metabolism_Homo sapiens_hsa007500.83846334
53Fatty acid degradation_Homo sapiens_hsa000710.83523987
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82632489
55Tryptophan metabolism_Homo sapiens_hsa003800.81322513
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79090049
57Non-homologous end-joining_Homo sapiens_hsa034500.78892472
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78271509
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.77504340
60Phototransduction_Homo sapiens_hsa047440.77379130
61Nucleotide excision repair_Homo sapiens_hsa034200.76694938
62Fatty acid elongation_Homo sapiens_hsa000620.76206616
63Cardiac muscle contraction_Homo sapiens_hsa042600.76201149
64Selenocompound metabolism_Homo sapiens_hsa004500.75512855
65Measles_Homo sapiens_hsa051620.74421855
66Pyruvate metabolism_Homo sapiens_hsa006200.74339494
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74189735
68Spliceosome_Homo sapiens_hsa030400.71207053
69Other glycan degradation_Homo sapiens_hsa005110.68396421
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68339653
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67933415
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.65329700
73Retinol metabolism_Homo sapiens_hsa008300.62363146
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62049511
75Metabolic pathways_Homo sapiens_hsa011000.61458302
76One carbon pool by folate_Homo sapiens_hsa006700.59300790
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59219912
78Fatty acid metabolism_Homo sapiens_hsa012120.59152586
79Staphylococcus aureus infection_Homo sapiens_hsa051500.57159179
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55910797
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.55571855
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54654919
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54426243
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52492286
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50733038
86Leishmaniasis_Homo sapiens_hsa051400.50127348
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47527045
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44893744
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44523272
90Chemical carcinogenesis_Homo sapiens_hsa052040.44507841
91Herpes simplex infection_Homo sapiens_hsa051680.43795284
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43403614
93Epstein-Barr virus infection_Homo sapiens_hsa051690.40850807
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38750320
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.38685799
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.35694182
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32789898
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32121176
99Arachidonic acid metabolism_Homo sapiens_hsa005900.31028307
100Glutathione metabolism_Homo sapiens_hsa004800.30921024

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