LYNX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.66288394
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59942754
3locomotory exploration behavior (GO:0035641)5.43024931
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02169423
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.92399157
6synaptic vesicle exocytosis (GO:0016079)4.91682814
7vocalization behavior (GO:0071625)4.79234180
8neuronal action potential propagation (GO:0019227)4.78603171
9glutamate secretion (GO:0014047)4.78238921
10cerebellar granule cell differentiation (GO:0021707)4.75200696
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.64894990
12regulation of synaptic vesicle exocytosis (GO:2000300)4.55457172
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.51600220
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49517490
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.43748378
16regulation of synapse structural plasticity (GO:0051823)4.40853582
17amino acid import (GO:0043090)4.36833546
18regulation of glutamate receptor signaling pathway (GO:1900449)4.27763972
19sodium ion export (GO:0071436)4.22233238
20cellular potassium ion homeostasis (GO:0030007)4.21871187
21regulation of synaptic vesicle transport (GO:1902803)4.15254960
22neurotransmitter secretion (GO:0007269)4.15002577
23regulation of neuronal synaptic plasticity (GO:0048168)4.02387197
24cell communication by electrical coupling (GO:0010644)4.01180233
25exploration behavior (GO:0035640)3.96644729
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96493939
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.95973787
28protein localization to synapse (GO:0035418)3.86629376
29central nervous system myelination (GO:0022010)3.78377587
30axon ensheathment in central nervous system (GO:0032291)3.78377587
31activation of protein kinase A activity (GO:0034199)3.74969993
32positive regulation of dendritic spine development (GO:0060999)3.74764828
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.72244333
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.70797117
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70524933
36layer formation in cerebral cortex (GO:0021819)3.60869795
37potassium ion import (GO:0010107)3.59885273
38long-term memory (GO:0007616)3.58925574
39synaptic transmission, glutamatergic (GO:0035249)3.58877111
40regulation of synapse maturation (GO:0090128)3.58145650
41neuromuscular process controlling posture (GO:0050884)3.57525925
42gamma-aminobutyric acid transport (GO:0015812)3.56486712
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56484658
44positive regulation of neurotransmitter secretion (GO:0001956)3.55691359
45negative regulation of dendrite morphogenesis (GO:0050774)3.55579395
46glutamate receptor signaling pathway (GO:0007215)3.53083452
47regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50464648
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50343403
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49865260
50proline transport (GO:0015824)3.49812177
51membrane depolarization during action potential (GO:0086010)3.49538219
52neuron-neuron synaptic transmission (GO:0007270)3.47045045
53cerebellar Purkinje cell differentiation (GO:0021702)3.45273343
54regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.45120589
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44388550
56regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.41634783
57postsynaptic membrane organization (GO:0001941)3.41102486
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.40096954
59cell communication involved in cardiac conduction (GO:0086065)3.39159134
60dendritic spine morphogenesis (GO:0060997)3.38741128
61regulation of vesicle fusion (GO:0031338)3.37044017
62neurotransmitter-gated ion channel clustering (GO:0072578)3.35409674
63neuromuscular process controlling balance (GO:0050885)3.35263556
64neurotransmitter transport (GO:0006836)3.31486756
65positive regulation of potassium ion transmembrane transport (GO:1901381)3.28285068
66positive regulation of membrane potential (GO:0045838)3.28050963
67regulation of postsynaptic membrane potential (GO:0060078)3.27001026
68regulation of membrane repolarization (GO:0060306)3.26279979
69neuron cell-cell adhesion (GO:0007158)3.24826502
70regulation of voltage-gated calcium channel activity (GO:1901385)3.21318764
71glycine transport (GO:0015816)3.20924086
72regulation of synaptic plasticity (GO:0048167)3.19957462
73regulation of dendritic spine morphogenesis (GO:0061001)3.18273850
74regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.18132261
75regulation of dendritic spine development (GO:0060998)3.17441886
76plasma membrane repair (GO:0001778)3.15963126
77dendritic spine organization (GO:0097061)3.12652905
78acidic amino acid transport (GO:0015800)3.12089566
79regulation of calcium ion transmembrane transporter activity (GO:1901019)3.11438585
80regulation of calcium ion transmembrane transport (GO:1903169)3.11438585
81regulation of neurotransmitter levels (GO:0001505)3.09243068
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.08649229
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07409845
84neurotransmitter uptake (GO:0001504)3.05428756
85synaptic vesicle endocytosis (GO:0048488)3.05178309
86regulation of neurotransmitter secretion (GO:0046928)3.04822689
87prepulse inhibition (GO:0060134)3.04226808
88membrane depolarization (GO:0051899)3.03954489
89potassium ion homeostasis (GO:0055075)3.02965921
90chemosensory behavior (GO:0007635)3.02364984
91positive regulation of synapse maturation (GO:0090129)3.01676354
92regulation of synaptic transmission (GO:0050804)2.98437732
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95619549
94long-term synaptic potentiation (GO:0060291)2.94810440
95regulation of cell communication by electrical coupling (GO:0010649)2.94723171
96vesicle docking involved in exocytosis (GO:0006904)2.94193128
97regulation of ARF protein signal transduction (GO:0032012)2.94086738
98detection of calcium ion (GO:0005513)2.93845014
99positive regulation of potassium ion transport (GO:0043268)2.93367868
100negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.93220755
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92942305
102regulation of synaptic transmission, glutamatergic (GO:0051966)2.92505133
103membrane repolarization (GO:0086009)2.91305153
104cerebellar Purkinje cell layer development (GO:0021680)2.90493653
105negative regulation of potassium ion transmembrane transport (GO:1901380)2.90226804
106transmission of nerve impulse (GO:0019226)2.89973025
107cellular sodium ion homeostasis (GO:0006883)2.89911852
108membrane hyperpolarization (GO:0060081)2.89206990
109positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.88886612
110vesicle transport along microtubule (GO:0047496)2.87363122
111regulation of ion transmembrane transporter activity (GO:0032412)2.86924208
112positive regulation of dendrite development (GO:1900006)2.86776223
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86679632
114neuronal ion channel clustering (GO:0045161)2.85411154
115regulation of neurotransmitter transport (GO:0051588)2.85390010
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84857722
117gamma-aminobutyric acid signaling pathway (GO:0007214)2.83867008
118positive regulation of neurotransmitter transport (GO:0051590)2.82968706
119striatum development (GO:0021756)2.82320476
120neuromuscular process (GO:0050905)2.82030286
121L-amino acid import (GO:0043092)2.80885979
122cell differentiation in hindbrain (GO:0021533)2.80853958
123auditory behavior (GO:0031223)2.78128781
124synaptic vesicle transport (GO:0048489)2.77162948
125establishment of synaptic vesicle localization (GO:0097480)2.77162948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72961982
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03758955
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99503207
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84190107
5DROSHA_22980978_ChIP-Seq_HELA_Human2.77849193
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.75968592
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73765458
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73765458
9GBX2_23144817_ChIP-Seq_PC3_Human2.72042514
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55402341
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54537144
12REST_21632747_ChIP-Seq_MESCs_Mouse2.53024930
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47511906
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42878821
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41593655
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31390264
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26549810
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.21512220
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.18771293
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18554100
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.18510833
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15085490
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08400306
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08374597
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.00480627
26* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82082156
27AR_21572438_ChIP-Seq_LNCaP_Human1.76198575
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.65222054
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63248837
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59689972
31LXR_22292898_ChIP-Seq_THP-1_Human1.56198515
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47747753
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45373403
34SMAD4_21799915_ChIP-Seq_A2780_Human1.43742776
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40937484
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.40270772
37KDM2B_26808549_Chip-Seq_K562_Human1.39253260
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39212589
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36950344
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34307708
41* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32927751
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30692151
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30463461
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.30054667
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28912685
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26802652
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.26190983
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24633359
49ZNF274_21170338_ChIP-Seq_K562_Hela1.23456371
50AR_19668381_ChIP-Seq_PC3_Human1.23041327
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20454580
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20211427
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19904086
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19650230
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.19638333
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19583096
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18650995
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17289578
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14325080
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13930514
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.13783302
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12372579
63* SMC4_20622854_ChIP-Seq_HELA_Human1.11487257
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.11406720
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08517458
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07988370
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06149550
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04815135
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03355953
70CTCF_27219007_Chip-Seq_Bcells_Human1.03267823
71STAT3_23295773_ChIP-Seq_U87_Human1.03153501
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02156673
73AR_25329375_ChIP-Seq_VCAP_Human1.02117210
74TAF15_26573619_Chip-Seq_HEK293_Human1.01699859
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01435089
76AHR_22903824_ChIP-Seq_MCF-7_Human1.01282394
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01012760
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.99612961
79SMAD3_21741376_ChIP-Seq_HESCs_Human0.99362718
80RING1B_27294783_Chip-Seq_NPCs_Mouse0.98706091
81ARNT_22903824_ChIP-Seq_MCF-7_Human0.97068454
82OCT4_19829295_ChIP-Seq_ESCs_Human0.96343656
83TET1_21490601_ChIP-Seq_MESCs_Mouse0.95892658
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95760989
85P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95288470
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.95263449
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95221074
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95093365
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94834500
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94639543
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94054027
92KDM2B_26808549_Chip-Seq_DND41_Human0.93974744
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93901075
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93147282
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92128800
96TCF4_23295773_ChIP-Seq_U87_Human0.91696084
97ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91339565
98CREB1_26743006_Chip-Seq_LNCaP_Human0.90907368
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90712186
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90368371
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89970370
102TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89324969
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.89294977
104RXR_22108803_ChIP-Seq_LS180_Human0.89268638
105TP53_16413492_ChIP-PET_HCT116_Human0.88462216
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.87987316
107P300_19829295_ChIP-Seq_ESCs_Human0.86988013
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86774184
109KLF4_19829295_ChIP-Seq_ESCs_Human0.85823133
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85085662
111DPY_21335234_ChIP-Seq_ESCs_Mouse0.84871001
112EGR1_19032775_ChIP-ChIP_M12_Human0.84315087
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84311999
114TP53_23651856_ChIP-Seq_MEFs_Mouse0.83702994
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83579948
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83060428
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.82348024
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.82207412
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81956669
120* SMAD3_21741376_ChIP-Seq_ESCs_Human0.81695273
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79951554
122P68_20966046_ChIP-Seq_HELA_Human0.79732244
123MYC_19915707_ChIP-ChIP_AK7_Human0.77010418
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.76552349
125* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76512783
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.74698642
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74097713
128SMAD4_21741376_ChIP-Seq_ESCs_Human0.73652537
129GATA1_26923725_Chip-Seq_HPCs_Mouse0.72739171
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70874688
131* TBX20_22328084_ChIP-Seq_HEART_Mouse0.70685634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.27057512
2MP0003880_abnormal_central_pattern4.12800243
3* MP0003635_abnormal_synaptic_transmissio3.82672785
4MP0004270_analgesia3.41253808
5MP0009046_muscle_twitch3.12913286
6MP0009745_abnormal_behavioral_response3.12509078
7MP0002064_seizures2.97126572
8MP0002822_catalepsy2.96713559
9* MP0002063_abnormal_learning/memory/cond2.92324076
10MP0000751_myopathy2.74639647
11MP0001968_abnormal_touch/_nociception2.73002538
12MP0002837_dystrophic_cardiac_calcinosis2.72384671
13MP0002272_abnormal_nervous_system2.55398521
14MP0002572_abnormal_emotion/affect_behav2.43507433
15MP0002734_abnormal_mechanical_nocicepti2.35517540
16MP0003646_muscle_fatigue2.31915158
17MP0001486_abnormal_startle_reflex2.29221723
18MP0005423_abnormal_somatic_nervous2.27889495
19MP0008569_lethality_at_weaning2.21080903
20MP0004215_abnormal_myocardial_fiber2.06953709
21MP0002735_abnormal_chemical_nociception2.06843233
22MP0002736_abnormal_nociception_after2.04436670
23MP0002909_abnormal_adrenal_gland2.03111007
24MP0001501_abnormal_sleep_pattern1.99262366
25MP0004858_abnormal_nervous_system1.95057550
26MP0001440_abnormal_grooming_behavior1.85709314
27MP0002067_abnormal_sensory_capabilities1.84980294
28MP0004145_abnormal_muscle_electrophysio1.80640913
29MP0001970_abnormal_pain_threshold1.80398811
30MP0002733_abnormal_thermal_nociception1.77159756
31MP0009780_abnormal_chondrocyte_physiolo1.74982198
32MP0003329_amyloid_beta_deposits1.74927100
33MP0004084_abnormal_cardiac_muscle1.70178098
34MP0004036_abnormal_muscle_relaxation1.63973244
35MP0005386_behavior/neurological_phenoty1.63540394
36MP0004924_abnormal_behavior1.63540394
37* MP0004811_abnormal_neuron_physiology1.55083297
38MP0000749_muscle_degeneration1.51935454
39MP0002184_abnormal_innervation1.49449861
40MP0003137_abnormal_impulse_conducting1.44052156
41MP0004484_altered_response_of1.38651464
42MP0002557_abnormal_social/conspecific_i1.37517824
43MP0000955_abnormal_spinal_cord1.35668465
44MP0004085_abnormal_heartbeat1.35418892
45MP0003879_abnormal_hair_cell1.31894558
46* MP0002066_abnormal_motor_capabilities/c1.31875695
47* MP0003633_abnormal_nervous_system1.31318309
48MP0004233_abnormal_muscle_weight1.30931529
49MP0005646_abnormal_pituitary_gland1.28299128
50MP0004130_abnormal_muscle_cell1.25126694
51MP0004885_abnormal_endolymph1.23467419
52MP0000747_muscle_weakness1.22787887
53* MP0002882_abnormal_neuron_morphology1.19809399
54MP0004142_abnormal_muscle_tone1.19281801
55MP0005330_cardiomyopathy1.18622194
56MP0005620_abnormal_muscle_contractility1.18122385
57MP0006276_abnormal_autonomic_nervous1.17741126
58MP0001984_abnormal_olfaction1.15834017
59MP0004087_abnormal_muscle_fiber1.15760925
60MP0004510_myositis1.13636893
61MP0000579_abnormal_nail_morphology1.12813710
62MP0000013_abnormal_adipose_tissue1.12321110
63MP0002972_abnormal_cardiac_muscle1.10827127
64MP0003123_paternal_imprinting1.09649896
65* MP0003631_nervous_system_phenotype1.06598269
66* MP0000778_abnormal_nervous_system1.05815836
67MP0008874_decreased_physiological_sensi1.03536319
68MP0005623_abnormal_meninges_morphology1.02586823
69MP0001502_abnormal_circadian_rhythm1.01378320
70MP0002269_muscular_atrophy0.99416409
71MP0008961_abnormal_basal_metabolism0.99140464
72MP0004742_abnormal_vestibular_system0.96315990
73MP0003075_altered_response_to0.96111500
74MP0005409_darkened_coat_color0.94643549
75MP0002106_abnormal_muscle_physiology0.94391092
76MP0001348_abnormal_lacrimal_gland0.94333373
77MP0003705_abnormal_hypodermis_morpholog0.91488711
78MP0008775_abnormal_heart_ventricle0.91424572
79MP0001963_abnormal_hearing_physiology0.90586635
80MP0000759_abnormal_skeletal_muscle0.90389458
81MP0003690_abnormal_glial_cell0.89793643
82MP0001529_abnormal_vocalization0.89416470
83MP0003283_abnormal_digestive_organ0.89359318
84* MP0002229_neurodegeneration0.89246033
85MP0008872_abnormal_physiological_respon0.88546804
86MP0005535_abnormal_body_temperature0.88541311
87MP0000920_abnormal_myelination0.85053809
88MP0005369_muscle_phenotype0.84394221
89MP0005167_abnormal_blood-brain_barrier0.84204710
90MP0001905_abnormal_dopamine_level0.83228990
91* MP0002152_abnormal_brain_morphology0.83040232
92MP0003787_abnormal_imprinting0.82687011
93MP0003122_maternal_imprinting0.82318616
94MP0005551_abnormal_eye_electrophysiolog0.80051205
95MP0003634_abnormal_glial_cell0.79751122
96MP0006138_congestive_heart_failure0.77792273
97MP0001958_emphysema0.75692341
98MP0002090_abnormal_vision0.75355722
99MP0002069_abnormal_eating/drinking_beha0.74623351
100MP0001177_atelectasis0.74421515
101MP0010234_abnormal_vibrissa_follicle0.73033393
102MP0005645_abnormal_hypothalamus_physiol0.72221211
103MP0003632_abnormal_nervous_system0.71642788
104MP0001485_abnormal_pinna_reflex0.71625709
105MP0003172_abnormal_lysosome_physiology0.71247381
106MP0005385_cardiovascular_system_phenoty0.70823324
107MP0001544_abnormal_cardiovascular_syste0.70823324
108MP0004043_abnormal_pH_regulation0.70026846
109MP0000604_amyloidosis0.69121122
110MP0001346_abnormal_lacrimal_gland0.68771618
111MP0005166_decreased_susceptibility_to0.64707077
112MP0003045_fibrosis0.63489289
113MP0002295_abnormal_pulmonary_circulatio0.63265765
114MP0002638_abnormal_pupillary_reflex0.62774281
115MP0001299_abnormal_eye_distance/0.61508394
116MP0002332_abnormal_exercise_endurance0.60293038
117MP0005275_abnormal_skin_tensile0.59819472
118MP0010386_abnormal_urinary_bladder0.59222133
119MP0002249_abnormal_larynx_morphology0.57190698
120MP0004147_increased_porphyrin_level0.57078119
121MP0002133_abnormal_respiratory_system0.55067460
122MP0005388_respiratory_system_phenotype0.55067460
123MP0001986_abnormal_taste_sensitivity0.51185701
124MP0005165_increased_susceptibility_to0.50978462
125MP0010769_abnormal_survival0.49013748
126MP0005670_abnormal_white_adipose0.45376530

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.84532768
2Myokymia (HP:0002411)6.59599089
3Focal seizures (HP:0007359)5.08155282
4Visual hallucinations (HP:0002367)4.79297607
5Action tremor (HP:0002345)4.38910212
6Neurofibrillary tangles (HP:0002185)4.28191744
7Atonic seizures (HP:0010819)4.19230140
8Obstructive sleep apnea (HP:0002870)4.12399463
9Ventricular fibrillation (HP:0001663)3.98563431
10Febrile seizures (HP:0002373)3.97683871
11Sudden death (HP:0001699)3.86337292
12Progressive cerebellar ataxia (HP:0002073)3.83463649
13Epileptic encephalopathy (HP:0200134)3.75440122
14Bundle branch block (HP:0011710)3.73024095
15Absence seizures (HP:0002121)3.72035237
16Exercise-induced myalgia (HP:0003738)3.55695336
17Cerebral inclusion bodies (HP:0100314)3.50884831
18Generalized tonic-clonic seizures (HP:0002069)3.45048080
19Dysdiadochokinesis (HP:0002075)3.30904131
20Dialeptic seizures (HP:0011146)3.30769244
21Tetraplegia (HP:0002445)3.28692087
22Dysmetric saccades (HP:0000641)3.27857308
23Depression (HP:0000716)3.17678702
24Supranuclear gaze palsy (HP:0000605)3.14182478
25Gaze-evoked nystagmus (HP:0000640)3.13801584
26Ankle clonus (HP:0011448)3.12132136
27Poor eye contact (HP:0000817)3.10345786
28Impaired vibration sensation in the lower limbs (HP:0002166)3.07913441
29Prolonged QT interval (HP:0001657)3.00886734
30Postural instability (HP:0002172)2.98657336
31Broad-based gait (HP:0002136)2.96859047
32Dysmetria (HP:0001310)2.95904613
33Impaired social interactions (HP:0000735)2.95765855
34Abnormal social behavior (HP:0012433)2.95765855
35Atrial fibrillation (HP:0005110)2.92840713
36Anxiety (HP:0000739)2.92033669
37Cerebral hypomyelination (HP:0006808)2.88879896
38Syncope (HP:0001279)2.88243113
39Calf muscle hypertrophy (HP:0008981)2.87691483
40Urinary bladder sphincter dysfunction (HP:0002839)2.86323257
41Primary atrial arrhythmia (HP:0001692)2.84968462
42Truncal ataxia (HP:0002078)2.81697798
43Neuronal loss in central nervous system (HP:0002529)2.81199144
44Pheochromocytoma (HP:0002666)2.79776415
45Exercise-induced muscle cramps (HP:0003710)2.78742876
46Abnormal EKG (HP:0003115)2.77807002
47Muscle hypertrophy of the lower extremities (HP:0008968)2.75977560
48Delusions (HP:0000746)2.75245225
49Urinary urgency (HP:0000012)2.71000047
50Supraventricular tachycardia (HP:0004755)2.69110851
51Myotonia (HP:0002486)2.68065841
52Supraventricular arrhythmia (HP:0005115)2.61732473
53Annular pancreas (HP:0001734)2.60903363
54Scanning speech (HP:0002168)2.60056577
55Heart block (HP:0012722)2.58915210
56Hemiplegia (HP:0002301)2.57524069
57Limb dystonia (HP:0002451)2.54758025
58Abnormality of the calf musculature (HP:0001430)2.53174694
59Abnormality of the lower motor neuron (HP:0002366)2.52991565
60Sleep apnea (HP:0010535)2.50999429
61Abnormal eating behavior (HP:0100738)2.48449344
62Apathy (HP:0000741)2.48287888
63Intention tremor (HP:0002080)2.48235322
64Akinesia (HP:0002304)2.47702986
65Clonus (HP:0002169)2.46374929
66Ventricular arrhythmia (HP:0004308)2.45210687
67Rigidity (HP:0002063)2.44124943
68Peripheral hypomyelination (HP:0007182)2.42213053
69Impaired smooth pursuit (HP:0007772)2.41830608
70Genetic anticipation (HP:0003743)2.40788354
71Neuroendocrine neoplasm (HP:0100634)2.39635843
72Abnormal atrioventricular conduction (HP:0005150)2.39036763
73Hyporeflexia of lower limbs (HP:0002600)2.36545054
74Papilledema (HP:0001085)2.34269495
75Difficulty running (HP:0009046)2.33634674
76Amblyopia (HP:0000646)2.29872829
77Termporal pattern (HP:0011008)2.28430305
78Insidious onset (HP:0003587)2.28430305
79Torticollis (HP:0000473)2.27905782
80Lower limb amyotrophy (HP:0007210)2.24190110
81Epileptiform EEG discharges (HP:0011182)2.22108258
82Aplasia involving bones of the extremities (HP:0009825)2.21567046
83Aplasia involving bones of the upper limbs (HP:0009823)2.21567046
84Aplasia of the phalanges of the hand (HP:0009802)2.21567046
85Rapidly progressive (HP:0003678)2.20756008
86Diminished motivation (HP:0000745)2.19758938
87Resting tremor (HP:0002322)2.18942564
88Atrioventricular block (HP:0001678)2.18872085
89Bradykinesia (HP:0002067)2.16835187
90Spastic gait (HP:0002064)2.16802964
91Fetal akinesia sequence (HP:0001989)2.16004032
92EMG: myopathic abnormalities (HP:0003458)2.14686703
93Hyperventilation (HP:0002883)2.11747360
94Progressive inability to walk (HP:0002505)2.10240660
95Status epilepticus (HP:0002133)2.09941511
96Impaired vibratory sensation (HP:0002495)2.08938289
97Focal dystonia (HP:0004373)2.08801584
98Mutism (HP:0002300)2.07907768
99Hemiparesis (HP:0001269)2.07630691
100Abnormality of ocular smooth pursuit (HP:0000617)2.07562044
101Increased circulating renin level (HP:0000848)2.04807627
102Increased variability in muscle fiber diameter (HP:0003557)2.03076055
103Abnormality of the corticospinal tract (HP:0002492)2.02615900
104Central scotoma (HP:0000603)2.02483433
105Lower limb muscle weakness (HP:0007340)2.00238325
106Muscle fiber splitting (HP:0003555)1.99513728
107Spinal canal stenosis (HP:0003416)1.98991708
108Distal upper limb amyotrophy (HP:0007149)1.98692942
109Upper limb amyotrophy (HP:0009129)1.98692942
110Megalencephaly (HP:0001355)1.98006444
111Spastic tetraparesis (HP:0001285)1.97710946
112Stereotypic behavior (HP:0000733)1.97462318
113Neoplasm of the peripheral nervous system (HP:0100007)1.97062736
114Myoglobinuria (HP:0002913)1.95804126
115Pointed chin (HP:0000307)1.95516846
116Bronchomalacia (HP:0002780)1.95101857
117Turricephaly (HP:0000262)1.91901328
118Abnormality of saccadic eye movements (HP:0000570)1.91565945
119Diplopia (HP:0000651)1.89705346
120Abnormality of binocular vision (HP:0011514)1.89705346
121Incomplete penetrance (HP:0003829)1.88654631
122EEG with generalized epileptiform discharges (HP:0011198)1.88642691
123Choreoathetosis (HP:0001266)1.85575562
124Craniofacial dystonia (HP:0012179)1.84227766
125Slow progression (HP:0003677)1.83592445
126Ventricular tachycardia (HP:0004756)1.82589420
127Lower limb asymmetry (HP:0100559)1.81790357
128Abnormality of the foot musculature (HP:0001436)1.80525938
129Insomnia (HP:0100785)1.78792659
130Foot dorsiflexor weakness (HP:0009027)1.77866833
131Gait ataxia (HP:0002066)1.76386359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.06584731
2EPHA43.84027925
3MAP3K93.57600166
4MAP3K42.75889696
5MINK12.54589144
6PAK62.34013518
7DAPK22.30145665
8PRKD32.28346954
9KSR22.23786698
10LMTK22.23724802
11CAMKK12.13138815
12PHKG22.03766153
13PHKG12.03766153
14MAP2K71.96170350
15MAP2K41.89986346
16STK381.84479540
17NTRK11.83128048
18RIPK41.79613770
19PINK11.74855092
20NTRK21.64710134
21MARK11.63914046
22MAP3K121.60455694
23CDK51.40141682
24CAMKK21.36043333
25DAPK11.30755342
26NEK11.26533458
27CDK191.21402137
28KSR11.20129053
29GRK51.16684587
30RIPK11.15440397
31TYRO31.11909709
32PRPF4B1.10708868
33DMPK1.10260621
34ARAF1.10214645
35TAOK11.09873207
36NEK61.08843388
37WNK11.08796161
38PRKCH1.07897838
39MAP3K21.07519353
40CAMK11.06457260
41LATS21.05411720
42PRKCG1.03628549
43UHMK11.03549010
44TTN0.98175117
45FES0.98034939
46PDK40.97831661
47PDK30.97831661
48PAK30.96757538
49MAP3K130.96074958
50CAMK2A0.95929430
51RET0.95822296
52SIK20.95324531
53SGK4940.94111607
54SGK2230.94111607
55PLK20.93418377
56STK110.91710807
57TRIB30.91678326
58SGK30.91471370
59PDK10.85488701
60MAP3K70.85457187
61SGK20.82863127
62TNIK0.82474838
63CDC42BPA0.82258838
64PDPK10.82246136
65DYRK1A0.81428581
66OBSCN0.80826242
67PTK2B0.79586994
68LIMK10.78030948
69ALK0.77587255
70PNCK0.75701673
71TESK10.75648424
72CAMK2D0.72713640
73MAP3K110.72316834
74MAP3K10.71423533
75CDK150.71243240
76CDK180.70670418
77PKN10.69473765
78MAPK130.68748308
79SGK10.68220422
80CAMK40.66022482
81CDK140.65669115
82CAMK2B0.65475136
83TNK20.65469825
84RAF10.65045189
85MUSK0.64216996
86BRSK10.63828984
87BMPR20.61050375
88CAMK2G0.60442711
89CDK11A0.60180496
90BRAF0.59741616
91CAMK1G0.56396917
92CASK0.55783395
93OXSR10.53774429
94DAPK30.53498817
95RPS6KA30.53262561
96ROCK20.53170989
97MARK20.52259348
98FER0.50801934
99PRKD10.50055089
100MAP2K10.49274852
101PDGFRA0.48588342
102ROCK10.47551446
103MYLK0.46514592
104PRKG20.45532835
105NME10.44747116
106PRKCE0.44084489
107MAPK120.42641067
108MAPK100.42330343
109FYN0.42243541
110PDK20.40892825
111ICK0.40814192
112MAP2K60.40455397
113DDR20.40418890
114MOS0.40412446
115FGFR20.39294594
116MAPK40.36225765
117MAPK70.35806319
118PRKCZ0.33934222
119PRKCA0.32318112
120JAK10.31014618

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02756082
2Synaptic vesicle cycle_Homo sapiens_hsa047212.92343083
3Olfactory transduction_Homo sapiens_hsa047402.63208511
4Circadian entrainment_Homo sapiens_hsa047132.47906728
5Long-term potentiation_Homo sapiens_hsa047202.42838646
6GABAergic synapse_Homo sapiens_hsa047272.39046776
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31304569
8Glutamatergic synapse_Homo sapiens_hsa047242.28362035
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24551611
10Morphine addiction_Homo sapiens_hsa050322.20847737
11Amphetamine addiction_Homo sapiens_hsa050312.11835277
12Salivary secretion_Homo sapiens_hsa049702.08099638
13Gastric acid secretion_Homo sapiens_hsa049711.99434042
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98772891
15Insulin secretion_Homo sapiens_hsa049111.93166947
16Dopaminergic synapse_Homo sapiens_hsa047281.88289004
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85380612
18Cardiac muscle contraction_Homo sapiens_hsa042601.78163403
19Cholinergic synapse_Homo sapiens_hsa047251.77938123
20Oxytocin signaling pathway_Homo sapiens_hsa049211.69163961
21Vitamin B6 metabolism_Homo sapiens_hsa007501.67625321
22Calcium signaling pathway_Homo sapiens_hsa040201.62642280
23Renin secretion_Homo sapiens_hsa049241.60410092
24Nitrogen metabolism_Homo sapiens_hsa009101.58438394
25Taste transduction_Homo sapiens_hsa047421.55376767
26Dilated cardiomyopathy_Homo sapiens_hsa054141.51409813
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46733895
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45273173
29GnRH signaling pathway_Homo sapiens_hsa049121.44262438
30Long-term depression_Homo sapiens_hsa047301.43290989
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40723208
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34828207
33Cocaine addiction_Homo sapiens_hsa050301.28609316
34cAMP signaling pathway_Homo sapiens_hsa040241.27824906
35Gap junction_Homo sapiens_hsa045401.27491211
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25243619
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24582464
38Serotonergic synapse_Homo sapiens_hsa047261.24548855
39Type II diabetes mellitus_Homo sapiens_hsa049301.22527298
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16621941
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16563805
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09220610
43Estrogen signaling pathway_Homo sapiens_hsa049151.08715377
44Glioma_Homo sapiens_hsa052141.07784727
45Collecting duct acid secretion_Homo sapiens_hsa049661.02061986
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.98584481
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95022296
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92959832
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92820235
50Melanogenesis_Homo sapiens_hsa049160.90167381
51Dorso-ventral axis formation_Homo sapiens_hsa043200.89666248
52Pancreatic secretion_Homo sapiens_hsa049720.88017041
53ErbB signaling pathway_Homo sapiens_hsa040120.87573472
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.84526177
55Glucagon signaling pathway_Homo sapiens_hsa049220.80185035
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77995973
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75985491
58Thyroid hormone synthesis_Homo sapiens_hsa049180.75067555
59Oocyte meiosis_Homo sapiens_hsa041140.72403220
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72345883
61Axon guidance_Homo sapiens_hsa043600.71305179
62Phototransduction_Homo sapiens_hsa047440.69547113
63VEGF signaling pathway_Homo sapiens_hsa043700.69271080
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68807087
65Histidine metabolism_Homo sapiens_hsa003400.67903910
66MAPK signaling pathway_Homo sapiens_hsa040100.67226454
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64850012
68mTOR signaling pathway_Homo sapiens_hsa041500.63256811
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.63073535
70Choline metabolism in cancer_Homo sapiens_hsa052310.62916912
71Insulin signaling pathway_Homo sapiens_hsa049100.62875616
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62661641
73Arginine and proline metabolism_Homo sapiens_hsa003300.61807288
74Alzheimers disease_Homo sapiens_hsa050100.61300453
75Bile secretion_Homo sapiens_hsa049760.60053378
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59650908
77Vibrio cholerae infection_Homo sapiens_hsa051100.58077620
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57818417
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55850966
80Inositol phosphate metabolism_Homo sapiens_hsa005620.54173279
81Rap1 signaling pathway_Homo sapiens_hsa040150.53398424
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53201301
83Circadian rhythm_Homo sapiens_hsa047100.51873624
84Endocytosis_Homo sapiens_hsa041440.49253161
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48964648
86Ras signaling pathway_Homo sapiens_hsa040140.46928898
87Parkinsons disease_Homo sapiens_hsa050120.46446135
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.45235178
89Fatty acid biosynthesis_Homo sapiens_hsa000610.44087068
90Arginine biosynthesis_Homo sapiens_hsa002200.43865038
91Non-small cell lung cancer_Homo sapiens_hsa052230.42683337
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39672438
93Phenylalanine metabolism_Homo sapiens_hsa003600.39126803
94Mineral absorption_Homo sapiens_hsa049780.39113653
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38427671
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.37665705
97Oxidative phosphorylation_Homo sapiens_hsa001900.37527634
98beta-Alanine metabolism_Homo sapiens_hsa004100.36757005
99Renal cell carcinoma_Homo sapiens_hsa052110.35541975
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.35171289
101Endometrial cancer_Homo sapiens_hsa052130.34600846
102AMPK signaling pathway_Homo sapiens_hsa041520.34093715
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34067128
104Tight junction_Homo sapiens_hsa045300.31298185
105Ovarian steroidogenesis_Homo sapiens_hsa049130.31230461
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31013386
107Amoebiasis_Homo sapiens_hsa051460.30746444
108Platelet activation_Homo sapiens_hsa046110.30404195
109HIF-1 signaling pathway_Homo sapiens_hsa040660.28869799
110Insulin resistance_Homo sapiens_hsa049310.28593443
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28046266
112Prion diseases_Homo sapiens_hsa050200.27188830
113Focal adhesion_Homo sapiens_hsa045100.25668383
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24642956

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