LY6G6F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.27898823
2central nervous system myelination (GO:0022010)8.27898823
3response to pheromone (GO:0019236)7.57851116
4neutrophil activation involved in immune response (GO:0002283)7.42538961
5thrombin receptor signaling pathway (GO:0070493)7.33880498
6protein neddylation (GO:0045116)7.15120056
7positive regulation of dendritic spine morphogenesis (GO:0061003)6.78107650
8fatty acid elongation (GO:0030497)6.76059061
9import into cell (GO:0098657)6.41495103
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.06272337
11regulation of platelet aggregation (GO:0090330)5.96224469
12angiogenesis involved in wound healing (GO:0060055)5.74430551
13regulation of platelet activation (GO:0010543)5.65685496
14blood coagulation, intrinsic pathway (GO:0007597)5.38698798
15regulation of integrin-mediated signaling pathway (GO:2001044)5.34503154
16vitamin biosynthetic process (GO:0009110)5.32522283
17amyloid precursor protein metabolic process (GO:0042982)5.11085898
18myelination (GO:0042552)5.05985639
19axon ensheathment (GO:0008366)5.02648588
20ensheathment of neurons (GO:0007272)5.02648588
21adenosine receptor signaling pathway (GO:0001973)5.02217627
22platelet aggregation (GO:0070527)5.01400286
23long-chain fatty acid biosynthetic process (GO:0042759)4.99130613
24negative regulation of thymocyte apoptotic process (GO:0070244)4.96328240
25low-density lipoprotein particle remodeling (GO:0034374)4.95543761
26response to methylmercury (GO:0051597)4.90632545
27L-amino acid import (GO:0043092)4.89358096
28positive regulation of actin cytoskeleton reorganization (GO:2000251)4.79783781
29lipoxygenase pathway (GO:0019372)4.75786082
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.73707219
31vitamin transmembrane transport (GO:0035461)4.68818639
32positive regulation of cAMP-mediated signaling (GO:0043950)4.67534372
33heart trabecula formation (GO:0060347)4.66318750
34negative regulation of platelet activation (GO:0010544)4.62537904
35neutrophil activation (GO:0042119)4.52037168
36negative regulation of norepinephrine secretion (GO:0010700)4.50231194
37peptidyl-tyrosine autophosphorylation (GO:0038083)4.43192074
38negative regulation of heart rate (GO:0010459)4.41202466
39positive regulation of mast cell activation (GO:0033005)4.38393619
40positive regulation of lipid kinase activity (GO:0090218)4.35910451
41negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.35332780
42positive regulation of endothelial cell differentiation (GO:0045603)4.21373618
43platelet formation (GO:0030220)4.20677982
44negative regulation of calcium ion transport into cytosol (GO:0010523)4.08044827
45cholesterol biosynthetic process (GO:0006695)4.07848093
46positive regulation of macrophage differentiation (GO:0045651)4.06909412
47platelet degranulation (GO:0002576)4.06639078
48positive regulation of hemostasis (GO:1900048)4.05740432
49positive regulation of blood coagulation (GO:0030194)4.05740432
50nucleotide transmembrane transport (GO:1901679)4.04625616
51granulocyte activation (GO:0036230)3.94651124
52regulation of integrin activation (GO:0033623)3.94240959
53myelin maintenance (GO:0043217)3.91618770
54ear development (GO:0043583)3.91065235
55negative regulation of protein localization to cell surface (GO:2000009)3.90273745
56protein targeting to Golgi (GO:0000042)3.90222991
57positive regulation of dendritic spine development (GO:0060999)3.88879662
58G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.88416899
59purinergic nucleotide receptor signaling pathway (GO:0035590)3.83943948
60positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.81830220
61sprouting angiogenesis (GO:0002040)3.81188180
62negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.79950705
63synaptic vesicle maturation (GO:0016188)3.79199705
64sterol biosynthetic process (GO:0016126)3.78374552
65regulation of collateral sprouting (GO:0048670)3.70837548
66regulation of MHC class II biosynthetic process (GO:0045346)3.70053903
67positive regulation of coagulation (GO:0050820)3.64867431
68positive regulation of systemic arterial blood pressure (GO:0003084)3.64406292
69definitive hemopoiesis (GO:0060216)3.64368757
70platelet activation (GO:0030168)3.62006621
71beta-amyloid metabolic process (GO:0050435)3.61595153
72negative regulation of appetite (GO:0032099)3.59488531
73negative regulation of response to food (GO:0032096)3.59488531
74megakaryocyte development (GO:0035855)3.58140608
75polyamine biosynthetic process (GO:0006596)3.57262377
76regulation of homotypic cell-cell adhesion (GO:0034110)3.55296855
77fusion of sperm to egg plasma membrane (GO:0007342)3.54269451
78homotypic cell-cell adhesion (GO:0034109)3.53742112
79high-density lipoprotein particle remodeling (GO:0034375)3.51232828
80iron ion import (GO:0097286)3.50861686
81regulation of appetite (GO:0032098)3.50733710
82positive regulation of protein homodimerization activity (GO:0090073)3.50678449
83positive regulation of receptor recycling (GO:0001921)3.50204067
84regulation of macrophage derived foam cell differentiation (GO:0010743)3.47156791
85regulation of Golgi to plasma membrane protein transport (GO:0042996)3.44554805
86regulation of beta-amyloid formation (GO:1902003)3.44078774
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.41534712
88regulation of establishment or maintenance of cell polarity (GO:0032878)3.39590233
89trabecula formation (GO:0060343)3.38170143
90regulation of lipoprotein metabolic process (GO:0050746)3.36627676
91positive regulation of cell junction assembly (GO:1901890)3.35687363
92positive regulation of focal adhesion assembly (GO:0051894)3.35687363
93auditory behavior (GO:0031223)3.35637701
94cyclic nucleotide catabolic process (GO:0009214)3.33609132
95purinergic receptor signaling pathway (GO:0035587)3.32675539
96regulation of amyloid precursor protein catabolic process (GO:1902991)3.32236991
97amyloid precursor protein catabolic process (GO:0042987)3.31730966
98reverse cholesterol transport (GO:0043691)3.31178492
99positive regulation of Rho protein signal transduction (GO:0035025)3.28720029
100pyrimidine-containing compound transmembrane transport (GO:0072531)3.28571764
101establishment of protein localization to Golgi (GO:0072600)3.28028088
102polyol transport (GO:0015791)3.26881771
103regulation of dendritic spine morphogenesis (GO:0061001)3.26547508
104negative regulation of T cell apoptotic process (GO:0070233)3.26405652
105amino acid import (GO:0043090)3.26011461
106regulation of phosphatidylinositol 3-kinase activity (GO:0043551)3.22847357
107extracellular fibril organization (GO:0043206)3.21110760
108regulation of mast cell activation (GO:0033003)3.20733544
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.20061161
110response to UV-C (GO:0010225)3.19554631
111long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.19229055
112leukocyte degranulation (GO:0043299)3.19124404
113negative regulation of neural precursor cell proliferation (GO:2000178)3.16974743
114regulation of inositol phosphate biosynthetic process (GO:0010919)3.16771717
115negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.16667238
116retrograde transport, vesicle recycling within Golgi (GO:0000301)3.16634875
117regulation of norepinephrine secretion (GO:0014061)3.14183318
118glycerophospholipid catabolic process (GO:0046475)3.12827641
119termination of G-protein coupled receptor signaling pathway (GO:0038032)3.11599731
120membrane tubulation (GO:0097320)3.11356815
121positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)3.11333209
122long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.11011030
123superoxide anion generation (GO:0042554)3.09949390
124G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.09836929
125negative regulation of endothelial cell apoptotic process (GO:2000352)3.08595043
126positive regulation of interleukin-17 production (GO:0032740)3.08437787
127phospholipid homeostasis (GO:0055091)3.08385231
128regulation of lipid kinase activity (GO:0043550)3.06576973
129termination of signal transduction (GO:0023021)3.06485978
130regulation of cholesterol efflux (GO:0010874)3.05831389
131negative regulation of heart contraction (GO:0045822)3.05620202
132skeletal muscle tissue regeneration (GO:0043403)3.04558808
133mucosal immune response (GO:0002385)3.04048847
134purine ribonucleotide transport (GO:0015868)3.02978292
135negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.02762944
136positive regulation of adherens junction organization (GO:1903393)3.02404243
137regulation of memory T cell differentiation (GO:0043380)3.01064631
138regulation of mast cell activation involved in immune response (GO:0033006)3.01030667
139establishment of epithelial cell polarity (GO:0090162)2.97908377
140regulation of vascular permeability (GO:0043114)2.97199172
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.96903071
142positive regulation of mast cell degranulation (GO:0043306)2.96903071
143negative regulation of neurotransmitter transport (GO:0051589)2.96889132
144mechanosensory behavior (GO:0007638)2.96724794
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96306273
146mitochondrial calcium ion transport (GO:0006851)2.95803093
147leukocyte migration involved in inflammatory response (GO:0002523)2.94810324
148regulation of hemostasis (GO:1900046)2.94367088
149regulation of blood coagulation (GO:0030193)2.94367088
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94361131
151negative regulation of T-helper cell differentiation (GO:0045623)2.94361131
152regulation of female receptivity (GO:0045924)2.93232884
153negative regulation of neurotransmitter secretion (GO:0046929)2.93197815
154vascular endothelial growth factor signaling pathway (GO:0038084)2.92847760
155creatine metabolic process (GO:0006600)2.92431772
156regulation of mast cell degranulation (GO:0043304)2.92056565
157very long-chain fatty acid metabolic process (GO:0000038)2.92031086
158endothelial cell proliferation (GO:0001935)2.91541267
159N-terminal protein amino acid acetylation (GO:0006474)2.91474311
160positive regulation of cellular amide metabolic process (GO:0034250)2.91263116
161peptide catabolic process (GO:0043171)2.90944999
162substantia nigra development (GO:0021762)2.90496433
163NADPH regeneration (GO:0006740)2.90245473
164protein K11-linked deubiquitination (GO:0035871)2.89900229
165S-adenosylmethionine metabolic process (GO:0046500)2.89733860
166autophagic vacuole fusion (GO:0000046)2.88928371
167fatty-acyl-CoA metabolic process (GO:0035337)2.88761380
168virion attachment to host cell (GO:0019062)2.85894512
169adhesion of symbiont to host cell (GO:0044650)2.85894512
170negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84166497
171positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.82530873
172organ or tissue specific immune response (GO:0002251)2.81846645
173regulation of endothelial cell differentiation (GO:0045601)2.80047309
174cAMP catabolic process (GO:0006198)2.79811187
175vesicle targeting (GO:0006903)2.79158648
176establishment of endothelial barrier (GO:0061028)2.76332650
177oligodendrocyte differentiation (GO:0048709)2.75972308
178regulation of receptor recycling (GO:0001919)2.75879879
179head development (GO:0060322)2.75024725
180pyrimidine nucleoside catabolic process (GO:0046135)2.74376529
181Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74314127
182negative regulation of catecholamine secretion (GO:0033604)2.74138440
183photoreceptor cell differentiation (GO:0046530)2.72259903
184eye photoreceptor cell differentiation (GO:0001754)2.72259903
185negative regulation of receptor-mediated endocytosis (GO:0048261)2.72155116
186purine nucleotide transport (GO:0015865)2.68539000
187heme transport (GO:0015886)2.68384403
188cerebral cortex radially oriented cell migration (GO:0021799)2.68325267
189negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67884721
190peripheral nervous system axon ensheathment (GO:0032292)2.67484843
191myelination in peripheral nervous system (GO:0022011)2.67484843
192fatty-acyl-CoA biosynthetic process (GO:0046949)2.66713509
193GDP-mannose metabolic process (GO:0019673)2.65673324
194positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.65074142
195limb bud formation (GO:0060174)2.64451948
196positive regulation of dendrite morphogenesis (GO:0050775)2.62607018
197fat-soluble vitamin biosynthetic process (GO:0042362)12.3067608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.79478374
2* LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.09981779
3SCL_19346495_ChIP-Seq_HPC-7_Human3.73705426
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34319146
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30055151
6* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.17971909
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.12442965
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12306014
9IKZF1_21737484_ChIP-ChIP_HCT116_Human3.11406945
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.88808100
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.87292496
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.76720450
13* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.69778007
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56229819
15GATA2_19941826_ChIP-Seq_K562_Human2.53440708
16SPI1_23127762_ChIP-Seq_K562_Human2.50726499
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49157533
18GATA1_19941827_ChIP-Seq_MEL_Mouse2.46630620
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.45769416
20AR_21572438_ChIP-Seq_LNCaP_Human2.43325601
21GBX2_23144817_ChIP-Seq_PC3_Human2.35625142
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.20184190
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14711483
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11693853
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09255353
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06912847
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06101138
28SRY_22984422_ChIP-ChIP_TESTIS_Rat2.04241007
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03337686
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03216506
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02849016
32* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.02798836
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00572522
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.99267669
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.98610323
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.95319395
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.90356282
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.89286647
39EZH2_22144423_ChIP-Seq_EOC_Human1.83102992
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82675518
41DROSHA_22980978_ChIP-Seq_HELA_Human1.79204555
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78112470
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78112470
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76347032
45* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.75889784
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74522902
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74160185
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73786486
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72640229
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72335550
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70443011
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70046629
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.69538881
54IGF1R_20145208_ChIP-Seq_DFB_Human1.69097953
55* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65791279
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65743574
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.62362203
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59918570
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58776007
60HTT_18923047_ChIP-ChIP_STHdh_Human1.56755364
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.54507525
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.53798795
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.52812574
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52468430
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.51165899
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50222668
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.48333338
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47590124
69STAT1_20625510_ChIP-Seq_HELA_Human1.47524833
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46415869
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46200642
72ER_23166858_ChIP-Seq_MCF-7_Human1.45695128
73TAF15_26573619_Chip-Seq_HEK293_Human1.44482442
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43942466
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42729744
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41911872
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41911872
78GATA1_19941826_ChIP-Seq_K562_Human1.41012601
79GATA1_19941827_ChIP-Seq_MEL86_Mouse1.40730279
80GATA1_22025678_ChIP-Seq_K562_Human1.40357567
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.39371038
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39018971
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38521863
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.38513917
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35863420
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35642547
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.35363621
88RUNX_20019798_ChIP-Seq_JUKART_Human1.35265929
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32622552
90EWS_26573619_Chip-Seq_HEK293_Human1.32363886
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27328050
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27328050
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.26873061
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25620830
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23192925
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21964688
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21619266
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20847741
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20620171
100SPI1_20517297_ChIP-Seq_HL60_Human1.19017813
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16386850
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15888531
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14262245
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.13842727
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13793182
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.13220132
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11530801
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.10923012
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.08525660
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07237581
111CJUN_26792858_Chip-Seq_BT549_Human1.07231678
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06807932
113TP53_18474530_ChIP-ChIP_U2OS_Human1.06524519
114ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06324251
115POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05086208
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.04991401
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04865203
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04355389
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03689786
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02649046
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02472936
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01985470
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97756369
124TCF4_23295773_ChIP-Seq_U87_Human0.97043281
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96946643
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96747550
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.96600842
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.95997834
129STAT3_23295773_ChIP-Seq_U87_Human0.95428997
130SPI1_23547873_ChIP-Seq_NB4_Human0.95191842
131P300_19829295_ChIP-Seq_ESCs_Human0.95081525
132AR_25329375_ChIP-Seq_VCAP_Human0.94391112
133OCT1_27270436_Chip-Seq_PROSTATE_Human0.94203344
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93826808
135* CTCF_20526341_ChIP-Seq_ESCs_Human0.93364630
136REST_21632747_ChIP-Seq_MESCs_Mouse0.92523093
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92221546
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92174577
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.91565049
140STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90744886
141TBL1_22424771_ChIP-Seq_293T_Human0.90104749
142SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89990757
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89606654
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89577251
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89264208
146UTX_26944678_Chip-Seq_JUKART_Human0.89098227
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89016618
148JUN_21703547_ChIP-Seq_K562_Human0.88885385
149NCOR1_26117541_ChIP-Seq_K562_Human0.88540846
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.88089658
151GATA3_27048872_Chip-Seq_THYMUS_Human0.87984273
152* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87733682
153GATA3_21878914_ChIP-Seq_MCF-7_Human0.86937476
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86403945
155JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85547252
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.85125968
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85086826
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84511866
159KDM2B_26808549_Chip-Seq_REH_Human0.83490465
160ERG_20517297_ChIP-Seq_VCAP_Human0.83321123
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.82467533
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.81642891
163FUS_26573619_Chip-Seq_HEK293_Human0.81635066
164JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81630094
165OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81369959
166SMRT_27268052_Chip-Seq_Bcells_Human0.81341219
167BCAT_22108803_ChIP-Seq_LS180_Human0.81305269
168SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80840767
169SMAD4_21799915_ChIP-Seq_A2780_Human0.80431477
170TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79948549
171MYB_26560356_Chip-Seq_TH2_Human0.78473090
172PU_27001747_Chip-Seq_BMDM_Mouse0.77860946
173CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77414761
174CEBPB_22108803_ChIP-Seq_LS180_Human0.77221906
175TCF4_18268006_ChIP-ChIP_LS174T_Human0.76686791
176PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76327710
177TP53_16413492_ChIP-PET_HCT116_Human0.75855590
178VDR_24763502_ChIP-Seq_THP-1_Human0.75599837
179PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75554637
180CRX_20693478_ChIP-Seq_RETINA_Mouse0.74655479
181GATA3_26560356_Chip-Seq_TH2_Human0.74518008
182GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73880897
183CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73806262
184VDR_24787735_ChIP-Seq_THP-1_Human0.73751648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.67805802
2MP0000920_abnormal_myelination4.27127360
3MP0003806_abnormal_nucleotide_metabolis3.61460106
4MP0000465_gastrointestinal_hemorrhage3.23670467
5MP0003878_abnormal_ear_physiology3.08404983
6MP0005377_hearing/vestibular/ear_phenot3.08404983
7MP0003690_abnormal_glial_cell3.03346760
8MP0006138_congestive_heart_failure3.02547253
9MP0004742_abnormal_vestibular_system2.81038471
10MP0005409_darkened_coat_color2.77666159
11MP0001529_abnormal_vocalization2.77349677
12MP0005623_abnormal_meninges_morphology2.74890313
13MP0001485_abnormal_pinna_reflex2.73595224
14MP0005171_absent_coat_pigmentation2.58868203
15MP0005083_abnormal_biliary_tract2.57245955
16MP0003303_peritoneal_inflammation2.55551576
17MP0001905_abnormal_dopamine_level2.49423461
18MP0003329_amyloid_beta_deposits2.47466291
19MP0001486_abnormal_startle_reflex2.31292862
20MP0001835_abnormal_antigen_presentation2.27488641
21MP0004510_myositis2.26725125
22MP0000230_abnormal_systemic_arterial2.22854314
23MP0003183_abnormal_peptide_metabolism2.22479726
24MP0000343_altered_response_to2.19660936
25MP0005167_abnormal_blood-brain_barrier2.12707655
26MP0005410_abnormal_fertilization2.11614979
27MP0002736_abnormal_nociception_after2.09268029
28MP0001879_abnormal_lymphatic_vessel2.06614688
29MP0004134_abnormal_chest_morphology2.03142861
30MP0003566_abnormal_cell_adhesion2.00319650
31MP0002272_abnormal_nervous_system1.96193108
32MP0003880_abnormal_central_pattern1.95900533
33MP0003638_abnormal_response/metabolism_1.87218143
34MP0005084_abnormal_gallbladder_morpholo1.85843560
35MP0003632_abnormal_nervous_system1.83297512
36MP0010155_abnormal_intestine_physiology1.82554847
37MP0004043_abnormal_pH_regulation1.78837245
38MP0010678_abnormal_skin_adnexa1.76388415
39MP0003656_abnormal_erythrocyte_physiolo1.75013301
40MP0000579_abnormal_nail_morphology1.73659561
41MP0003634_abnormal_glial_cell1.73154771
42MP0003828_pulmonary_edema1.72193871
43MP0005671_abnormal_response_to1.72170747
44MP0002822_catalepsy1.66004529
45MP0001851_eye_inflammation1.65584524
46MP0004484_altered_response_of1.64843085
47MP0002102_abnormal_ear_morphology1.64816717
48MP0005000_abnormal_immune_tolerance1.64700124
49MP0004084_abnormal_cardiac_muscle1.62228601
50MP0004885_abnormal_endolymph1.61291553
51MP0004130_abnormal_muscle_cell1.60876096
52MP0004270_analgesia1.57427017
53MP0002108_abnormal_muscle_morphology1.56271062
54MP0008872_abnormal_physiological_respon1.55980152
55MP0002132_abnormal_respiratory_system1.50408998
56MP0000604_amyloidosis1.48300933
57MP0001663_abnormal_digestive_system1.47467774
58MP0003631_nervous_system_phenotype1.46996499
59MP0003436_decreased_susceptibility_to1.46978410
60MP0004272_abnormal_basement_membrane1.46407784
61MP0002398_abnormal_bone_marrow1.45618222
62MP0001968_abnormal_touch/_nociception1.43542460
63MP0002734_abnormal_mechanical_nocicepti1.39627177
64MP0002064_seizures1.36872253
65MP0008775_abnormal_heart_ventricle1.36617736
66MP0000249_abnormal_blood_vessel1.34664074
67MP0001533_abnormal_skeleton_physiology1.33301223
68MP0001986_abnormal_taste_sensitivity1.33027413
69MP0000778_abnormal_nervous_system1.32660512
70MP0002229_neurodegeneration1.31859899
71MP0001545_abnormal_hematopoietic_system1.31164234
72MP0005397_hematopoietic_system_phenotyp1.31164234
73MP0004947_skin_inflammation1.31079888
74MP0002723_abnormal_immune_serum1.29229209
75MP0008004_abnormal_stomach_pH1.28071520
76MP0004019_abnormal_vitamin_homeostasis1.27563288
77MP0005165_increased_susceptibility_to1.26833250
78MP0001800_abnormal_humoral_immune1.25104088
79MP0002452_abnormal_antigen_presenting1.23769364
80MP0003950_abnormal_plasma_membrane1.23298948
81MP0004036_abnormal_muscle_relaxation1.21276965
82MP0000462_abnormal_digestive_system1.20091967
83MP0003633_abnormal_nervous_system1.19717303
84MP0001177_atelectasis1.19639889
85MP0001440_abnormal_grooming_behavior1.19333412
86MP0000383_abnormal_hair_follicle1.19294778
87MP0010329_abnormal_lipoprotein_level1.18904796
88MP0002419_abnormal_innate_immunity1.16534087
89MP0001346_abnormal_lacrimal_gland1.16466964
90MP0001970_abnormal_pain_threshold1.16426415
91MP0003453_abnormal_keratinocyte_physiol1.16009071
92MP0009763_increased_sensitivity_to1.15478267
93MP0000566_synostosis1.15031780
94MP0009764_decreased_sensitivity_to1.14753347
95MP0003879_abnormal_hair_cell1.14396998
96MP0005646_abnormal_pituitary_gland1.14366630
97MP0008874_decreased_physiological_sensi1.14043828
98MP0003866_abnormal_defecation1.13920252
99MP0000685_abnormal_immune_system1.13811123
100MP0010234_abnormal_vibrissa_follicle1.11508283
101MP0002420_abnormal_adaptive_immunity1.10502952
102MP0005310_abnormal_salivary_gland1.10205768
103MP0001819_abnormal_immune_cell1.09178614
104MP0002429_abnormal_blood_cell1.08762344
105MP0002098_abnormal_vibrissa_morphology1.08550521
106MP0005025_abnormal_response_to1.08242044
107MP0004859_abnormal_synaptic_plasticity1.07810595
108MP0004142_abnormal_muscle_tone1.07199589
109MP0005386_behavior/neurological_phenoty1.06810806
110MP0004924_abnormal_behavior1.06810806
111MP0006276_abnormal_autonomic_nervous1.06000571
112MP0002572_abnormal_emotion/affect_behav1.05925719
113MP0001845_abnormal_inflammatory_respons1.04874063
114MP0001873_stomach_inflammation1.04434092
115MP0002653_abnormal_ependyma_morphology1.04407045
116MP0001963_abnormal_hearing_physiology1.02138017
117MP0000689_abnormal_spleen_morphology1.02015663
118MP0006082_CNS_inflammation1.01948565
119MP0002557_abnormal_social/conspecific_i1.01161008
120MP0009642_abnormal_blood_homeostasis1.00191641
121MP0001790_abnormal_immune_system0.98872914
122MP0005387_immune_system_phenotype0.98872914
123MP0000858_altered_metastatic_potential0.97637644
124MP0002722_abnormal_immune_system0.96150684
125MP0002295_abnormal_pulmonary_circulatio0.95632891
126MP0000716_abnormal_immune_system0.95083392
127MP0004381_abnormal_hair_follicle0.92903578
128MP0002063_abnormal_learning/memory/cond0.91445490
129MP0003724_increased_susceptibility_to0.91140604
130MP0005381_digestive/alimentary_phenotyp0.90930407
131MP0002733_abnormal_thermal_nociception0.90862794
132MP0009697_abnormal_copulation0.90123724
133MP0000613_abnormal_salivary_gland0.89593414
134MP0004215_abnormal_myocardial_fiber0.89118906
135MP0005058_abnormal_lysosome_morphology0.89100470
136MP0002882_abnormal_neuron_morphology0.88267548
137MP0002066_abnormal_motor_capabilities/c0.86861128
138MP0000955_abnormal_spinal_cord0.86243787
139MP0005388_respiratory_system_phenotype0.85984839
140MP0002133_abnormal_respiratory_system0.85984839
141MP0003635_abnormal_synaptic_transmissio0.85588096
142MP0005670_abnormal_white_adipose0.85059757
143MP0005551_abnormal_eye_electrophysiolog0.84868221
144MP0009046_muscle_twitch0.84768334
145MP0005647_abnormal_sex_gland0.84393096
146MP0000015_abnormal_ear_pigmentation0.83948263
147MP0009333_abnormal_splenocyte_physiolog0.83647820
148MP0000647_abnormal_sebaceous_gland0.82798011
149MP0006054_spinal_hemorrhage0.79469792
150MP0002148_abnormal_hypersensitivity_rea0.78958289
151MP0009745_abnormal_behavioral_response0.78606239
152MP0000747_muscle_weakness0.77793231
153MP0003300_gastrointestinal_ulcer0.76859794
154MP0000733_abnormal_muscle_development0.76471584
155MP0001664_abnormal_digestion0.75915180
156MP0009765_abnormal_xenobiotic_induced0.75551315
157MP0002067_abnormal_sensory_capabilities0.75468483
158MP0003195_calcinosis0.75054228
159MP0009840_abnormal_foam_cell0.74389103
160MP0005408_hypopigmentation0.73695196
161MP0002998_abnormal_bone_remodeling0.73521714
162MP0002752_abnormal_somatic_nervous0.73159919
163MP0002735_abnormal_chemical_nociception0.72555521
164MP0002796_impaired_skin_barrier0.72406132
165MP0005666_abnormal_adipose_tissue0.71586086
166MP0001765_abnormal_ion_homeostasis0.70403262
167MP0003075_altered_response_to0.70379781
168MP0003136_yellow_coat_color0.69986170
169MP0002118_abnormal_lipid_homeostasis0.69542649
170MP0009278_abnormal_bone_marrow0.68737552
171MP0002972_abnormal_cardiac_muscle0.67472432
172MP0000467_abnormal_esophagus_morphology0.67294500
173MP0001544_abnormal_cardiovascular_syste0.65831358
174MP0005385_cardiovascular_system_phenoty0.65831358
175MP0000762_abnormal_tongue_morphology0.65060066
176MP0000490_abnormal_crypts_of0.64149383
177MP0005187_abnormal_penis_morphology0.63506361
178MP0005174_abnormal_tail_pigmentation0.63410877
179MP0006036_abnormal_mitochondrial_physio0.63320009
180MP0009785_altered_susceptibility_to0.62177441

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.75311300
2Epistaxis (HP:0000421)7.65095793
3Hyperlipoproteinemia (HP:0010980)6.35368913
4Gingival bleeding (HP:0000225)6.30516423
5Degeneration of the lateral corticospinal tracts (HP:0002314)5.85981258
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.85981258
7Abnormal platelet function (HP:0011869)5.34563349
8Impaired platelet aggregation (HP:0003540)5.34563349
9Aplasia/Hypoplasia of the spleen (HP:0010451)4.69139275
10Abnormality of the corticospinal tract (HP:0002492)4.53924503
11Abnormality of the phalanges of the 2nd finger (HP:0009541)4.22774838
12Poikilocytosis (HP:0004447)4.12313263
13Neurofibrillary tangles (HP:0002185)4.08857181
14Spontaneous hematomas (HP:0007420)4.06845865
15Acanthocytosis (HP:0001927)3.86772589
16Absent hand (HP:0004050)3.84863417
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.82474713
18Petechiae (HP:0000967)3.77567092
19Increased circulating renin level (HP:0000848)3.75162575
20Dyschromatopsia (HP:0007641)3.69186215
21Metabolic alkalosis (HP:0200114)3.59470881
22Parakeratosis (HP:0001036)3.52003517
23Hypoplasia of the uterus (HP:0000013)3.48616794
24Conjunctival telangiectasia (HP:0000524)3.44600187
25Hypomagnesemia (HP:0002917)3.40072770
26Bruising susceptibility (HP:0000978)3.39423035
27Annular pancreas (HP:0001734)3.37096267
28Breast hypoplasia (HP:0003187)3.36910486
29Abnormal pupillary function (HP:0007686)3.31022308
30Abnormality of the heme biosynthetic pathway (HP:0010472)3.29646163
31Abnormality of the common coagulation pathway (HP:0010990)3.27187223
32Esophageal atresia (HP:0002032)3.19774483
33Progressive external ophthalmoplegia (HP:0000590)3.18750096
34Cerebral hypomyelination (HP:0006808)3.17535224
35Abnormality of lateral ventricle (HP:0030047)3.09595558
36Tetany (HP:0001281)3.09160687
37Increased IgM level (HP:0003496)3.07985308
38Hyperinsulinemic hypoglycemia (HP:0000825)3.04717583
39Thick nail (HP:0001805)3.03146838
40Stomatitis (HP:0010280)3.03117426
41Conical tooth (HP:0000698)3.01513939
42Hypokalemic alkalosis (HP:0001949)2.99823772
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.98019960
44Hemorrhage of the eye (HP:0011885)2.89915779
45Abnormality of incisor morphology (HP:0011063)2.88495161
46Onion bulb formation (HP:0003383)2.86850061
47Tinnitus (HP:0000360)2.82773232
48Increased density of long bones (HP:0006392)2.82693252
49Aplasia/hypoplasia of the uterus (HP:0008684)2.79618729
50Cerebral inclusion bodies (HP:0100314)2.78470582
51Peripheral hypomyelination (HP:0007182)2.76359918
52Segmental peripheral demyelination/remyelination (HP:0003481)2.71928962
53Asplenia (HP:0001746)2.70103400
54Abnormality of macrophages (HP:0004311)2.70001964
553-Methylglutaconic aciduria (HP:0003535)2.69260768
56Congenital ichthyosiform erythroderma (HP:0007431)2.67088836
57Leukodystrophy (HP:0002415)2.61143100
58Supranuclear gaze palsy (HP:0000605)2.60569495
59Hypoplastic nipples (HP:0002557)2.57965799
60Abnormality of magnesium homeostasis (HP:0004921)2.56206532
61Abnormality of the middle phalanges of the toes (HP:0010183)2.53678371
62Encephalitis (HP:0002383)2.51509336
63Abnormality of the 2nd finger (HP:0004100)2.48313305
64Alacrima (HP:0000522)2.46074309
65Joint swelling (HP:0001386)2.45624498
66Axonal loss (HP:0003447)2.41974981
67Ridged nail (HP:0001807)2.41319831
68Dysmetria (HP:0001310)2.41057018
69Ventricular fibrillation (HP:0001663)2.40958856
70Abnormal auditory evoked potentials (HP:0006958)2.40908341
71Decreased central vision (HP:0007663)2.37189899
72Sensory axonal neuropathy (HP:0003390)2.31771735
73Arterial thrombosis (HP:0004420)2.31641379
74Joint hemorrhage (HP:0005261)2.30533341
75Hyperactive renin-angiotensin system (HP:0000841)2.26504856
76Blue irides (HP:0000635)2.25531507
77Retinal dysplasia (HP:0007973)2.25126110
78Spastic gait (HP:0002064)2.24819944
79Increased CSF protein (HP:0002922)2.23279601
80Premature skin wrinkling (HP:0100678)2.21849158
81Glucose intolerance (HP:0000833)2.21632485
82Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21557443
83Ankle clonus (HP:0011448)2.20626131
84Delayed epiphyseal ossification (HP:0002663)2.19414625
85Abnormality of iron homeostasis (HP:0011031)2.18975410
86Congenital sensorineural hearing impairment (HP:0008527)2.18759269
87Episodic fever (HP:0001954)2.18126192
88Generalized aminoaciduria (HP:0002909)2.18021730
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17744766
90Morphological abnormality of the inner ear (HP:0011390)2.17355475
91Intention tremor (HP:0002080)2.15972521
92Dysautonomia (HP:0002459)2.15309555
93Vertigo (HP:0002321)2.10360873
94Insidious onset (HP:0003587)2.09312968
95Termporal pattern (HP:0011008)2.09312968
96Upper limb muscle weakness (HP:0003484)2.08310451
97Abnormal ciliary motility (HP:0012262)2.06750021
98Abnormal pancreas size (HP:0012094)2.05531577
99Basal ganglia calcification (HP:0002135)2.05344673
100Male infertility (HP:0003251)2.04983107
101Chronic obstructive pulmonary disease (HP:0006510)2.04088974
102Obstructive lung disease (HP:0006536)2.04088974
103Purpura (HP:0000979)2.04075407
104Ectopic kidney (HP:0000086)2.02686641
105Hyperaldosteronism (HP:0000859)2.00657078
106Symptomatic seizures (HP:0011145)2.00647013
107Duplicated collecting system (HP:0000081)2.00517769
108Prolonged bleeding time (HP:0003010)11.7981094
109Menorrhagia (HP:0000132)10.5659672
110Increased mean platelet volume (HP:0011877)10.2701036
111Decreased lacrimation (HP:0000633)1.99265127
112Nausea (HP:0002018)1.98475185
113Humeroradial synostosis (HP:0003041)1.97434159
114Synostosis involving the elbow (HP:0003938)1.97434159
115Eczematoid dermatitis (HP:0000976)1.96874406
116Peripheral demyelination (HP:0011096)1.96060598
117Polydipsia (HP:0001959)1.94265118
118Abnormal drinking behavior (HP:0030082)1.94265118
119Absent/shortened dynein arms (HP:0200106)1.94188315
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.94188315
121Coronal craniosynostosis (HP:0004440)1.93587843
122Truncus arteriosus (HP:0001660)1.91911936
123Action tremor (HP:0002345)1.90114069
124Abnormality of transition element cation homeostasis (HP:0011030)1.89499355
125Optic neuritis (HP:0100653)1.89124493
126Retrobulbar optic neuritis (HP:0100654)1.89124493
127Absent septum pellucidum (HP:0001331)1.88835361
128Anteriorly placed anus (HP:0001545)1.87901485
129Polycythemia (HP:0001901)1.84689093
130Increased serum ferritin (HP:0003281)1.84520368
131Slow saccadic eye movements (HP:0000514)1.84302054
132Papillary thyroid carcinoma (HP:0002895)1.81841472
133Bilateral microphthalmos (HP:0007633)1.81382097
134Thyroid-stimulating hormone excess (HP:0002925)1.81277316
135Scapular winging (HP:0003691)1.80409716
136Arthropathy (HP:0003040)1.80250043
137Cone-rod dystrophy (HP:0000548)1.80196650
138Spontaneous abortion (HP:0005268)1.79094599
139Abnormal respiratory motile cilium morphology (HP:0005938)1.77922844
140Abnormal respiratory epithelium morphology (HP:0012253)1.77922844
141Supernumerary ribs (HP:0005815)1.77748581
142Increased IgE level (HP:0003212)1.77603401
143Tongue fasciculations (HP:0001308)1.77027293
144Muscle fibrillation (HP:0010546)1.77014892
145Hypoplastic pelvis (HP:0008839)1.76615214
146Microretrognathia (HP:0000308)1.76217896
147Keratoconjunctivitis (HP:0001096)1.75229720
148Clumsiness (HP:0002312)1.74922957
149Bilateral sensorineural hearing impairment (HP:0008619)1.74906943
150Abnormality of fatty-acid metabolism (HP:0004359)1.73951763
151Biliary tract neoplasm (HP:0100574)1.73103468
152Spastic paraparesis (HP:0002313)1.72646551
153Abnormality of the renal collecting system (HP:0004742)1.72014359
154Supernumerary bones of the axial skeleton (HP:0009144)1.71257301
155Xanthomatosis (HP:0000991)1.70161377
156Paralysis (HP:0003470)1.69371389
157Aplasia involving bones of the upper limbs (HP:0009823)1.68536678
158Aplasia of the phalanges of the hand (HP:0009802)1.68536678
159Aplasia involving bones of the extremities (HP:0009825)1.68536678
160Abnormal glucose tolerance (HP:0001952)1.68222337
161Hepatosplenomegaly (HP:0001433)1.67909279
162Renal salt wasting (HP:0000127)1.67824601
163Dysostosis multiplex (HP:0000943)1.65125977
164Myocardial infarction (HP:0001658)1.64248772
165Abnormality of the prostate (HP:0008775)1.64058546
166Orchitis (HP:0100796)1.64032412
167Keratoconjunctivitis sicca (HP:0001097)1.63552149
168Infertility (HP:0000789)1.62260921
169Hypophosphatemic rickets (HP:0004912)1.61355327
170Ileus (HP:0002595)1.61119782
171Hyperthyroidism (HP:0000836)1.59538578
172Testicular neoplasm (HP:0010788)1.59069656
173Chest pain (HP:0100749)1.57790921
174Distal lower limb amyotrophy (HP:0008944)1.57316020
175Thrombophlebitis (HP:0004418)1.56595497
176Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.55106072
177Myositis (HP:0100614)1.53447462
178Pulmonary embolism (HP:0002204)1.50306391
179Recurrent abscess formation (HP:0002722)1.48335979
180Autoimmune hemolytic anemia (HP:0001890)1.46554394
181Cerebral ischemia (HP:0002637)1.46212854
182Abolished electroretinogram (ERG) (HP:0000550)1.45729783
183Abnormality of binocular vision (HP:0011514)1.44582214
184Diplopia (HP:0000651)1.44582214
185Elevated erythrocyte sedimentation rate (HP:0003565)1.41847934
186Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.39957336
187Abnormality of alanine metabolism (HP:0010916)1.39957336
188Hyperalaninemia (HP:0003348)1.39957336
189Recurrent bacterial skin infections (HP:0005406)1.39071352
190Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.38303052
191Polyphagia (HP:0002591)1.37416587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.13912258
2MYLK3.60419023
3BTK3.08221430
4BMX3.02342517
5GRK12.91330894
6PTK2B2.69018612
7EIF2AK12.67205363
8STK392.54973148
9TAOK32.47746989
10BLK2.40438757
11CAMK1D2.39051723
12TEC2.37067971
13SYK2.25664196
14CSF1R2.24497813
15MAPKAPK52.17014046
16GRK52.15639852
17ZAP702.14330127
18GRK62.09408473
19MAPKAPK32.02416213
20TIE113.1409311
21ILK1.95836568
22TNIK1.93081624
23CAMK1G1.91512446
24TXK1.90016800
25PIK3CG1.79636359
26PBK1.72260105
27FRK1.62961302
28OXSR11.48443443
29HCK1.46706412
30TNK21.34258764
31EPHB11.32328288
32STK31.31230269
33BCR1.30573686
34LYN1.29310519
35ICK1.25232105
36TSSK61.24507446
37PKN11.24436034
38PLK21.21940777
39UHMK11.21134020
40MAP2K31.19167895
41IRAK11.15739815
42PAK11.15476407
43TRPM71.14867133
44SGK2231.13298562
45SGK4941.13298562
46DAPK31.07933013
47LMTK21.07591334
48FER1.03269234
49MET1.01476005
50NEK61.00590517
51STK241.00217476
52ACVR1B0.97653975
53MATK0.96800331
54DAPK20.90511671
55ITK0.90074409
56SIK30.89258873
57EPHA30.88680520
58FGFR20.88556519
59ADRBK10.87647415
60MARK30.84580819
61WNK40.84223653
62TLK10.83120771
63MAPK130.82153472
64ERBB20.79567652
65PIM20.79555326
66PRKCE0.79147335
67PRKCG0.78809013
68YES10.78783290
69TAOK20.78565480
70MST40.76837935
71WNK30.75955919
72CSNK1A1L0.74563195
73GRK70.74209390
74MAP2K20.74083850
75CSNK1G30.73208938
76MKNK10.73196273
77PINK10.72521464
78RET0.71427128
79MAP3K50.71212239
80CAMK2B0.70470571
81CLK10.70307714
82NTRK10.69456180
83PRPF4B0.67995113
84PDK10.66240025
85TAOK10.65008739
86TESK20.64193996
87ROCK20.61777588
88KDR0.60967945
89MAP4K10.60252670
90MAP3K30.57682991
91BMPR1B0.57105149
92IKBKB0.56904953
93EPHB20.56275359
94DAPK10.55476710
95IRAK20.54906586
96TYRO30.54704481
97ADRBK20.54636681
98EPHA40.54402400
99LCK0.54354612
100CSNK1G20.54099288
101ZAK0.54050349
102CSNK1G10.53241577
103PDPK10.52580129
104TRIM280.52124140
105PIK3CA0.51123147
106PAK30.50797947
107PRKACG0.49474294
108NUAK10.47746402
109FES0.46617602
110DYRK20.45886438
111INSRR0.43979540
112CAMK2D0.43975104
113PDGFRB0.43361917
114PAK60.43206170
115JAK20.42461616
116BMPR20.41262277
117JAK10.40039130
118PRKCQ0.39658107
119KSR20.38321900
120LIMK10.38301877
121CDK190.35896832
122CAMK2A0.35443029
123IRAK40.33297761
124SGK20.33021775
125WNK10.32926737
126MINK10.32387953
127IGF1R0.31953667
128CSNK1D0.31896602
129INSR0.31781056
130MAP3K110.31141534
131JAK30.31058983
132IRAK30.30888246
133MARK10.30709155
134PRKD10.29580468
135CAMKK20.28735460
136STK40.26984888
137SGK30.26533813
138MAP4K20.25780119
139GSK3A0.25455638
140PRKCD0.25064788
141CAMK10.24338473
142ROCK10.23741962
143SRC0.23638153
144EGFR0.23115600
145PRKAA20.22787430
146ARAF0.22705931
147PIM10.21755501
148PRKCI0.21619723
149BUB10.21554687
150FYN0.21422615
151MAPK40.20963335
152MAPK120.20845705
153CAMK40.20598738
154PRKCA0.20191811
155FGR0.18895667
156CAMK2G0.18460121
157MARK20.17157603
158MAP2K10.16715079
159CDK50.16510508
160PRKCB0.16308452
161PRKACA0.14866894
162PRKCZ0.14783343
163PNCK0.14426153
164EIF2AK20.14154411
165CSNK1A10.14051700
166CDK140.13617067
167SGK10.13549311
168PRKG10.13118472
169PRKCH0.12460622
170CSK0.12263711
171MAP3K20.12254329

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.58749100
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.53919701
3Fatty acid elongation_Homo sapiens_hsa000624.44432650
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41781539
5Rheumatoid arthritis_Homo sapiens_hsa053232.65963726
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.53042323
7Ether lipid metabolism_Homo sapiens_hsa005652.50051483
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48456537
9Hematopoietic cell lineage_Homo sapiens_hsa046402.43593173
10Vitamin B6 metabolism_Homo sapiens_hsa007502.36886617
11Ovarian steroidogenesis_Homo sapiens_hsa049132.21509744
12Nitrogen metabolism_Homo sapiens_hsa009101.94714627
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84330115
14Bile secretion_Homo sapiens_hsa049761.71166438
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68214476
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56268952
17Histidine metabolism_Homo sapiens_hsa003401.48493281
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47583703
19Sulfur metabolism_Homo sapiens_hsa009201.47289786
20Glycerolipid metabolism_Homo sapiens_hsa005611.40275784
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40017472
22Sphingolipid metabolism_Homo sapiens_hsa006001.37686734
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36919725
24Gastric acid secretion_Homo sapiens_hsa049711.36684053
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36560775
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36083089
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.35353314
28Butanoate metabolism_Homo sapiens_hsa006501.31797099
29Morphine addiction_Homo sapiens_hsa050321.26853220
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23870848
31Oxidative phosphorylation_Homo sapiens_hsa001901.23054375
32Glutamatergic synapse_Homo sapiens_hsa047241.22243751
33PPAR signaling pathway_Homo sapiens_hsa033201.21757321
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20351007
35Systemic lupus erythematosus_Homo sapiens_hsa053221.19922123
36Staphylococcus aureus infection_Homo sapiens_hsa051501.19625545
37Alcoholism_Homo sapiens_hsa050341.18956366
38Linoleic acid metabolism_Homo sapiens_hsa005911.17908775
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17353791
40Axon guidance_Homo sapiens_hsa043601.15192652
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14963248
42Olfactory transduction_Homo sapiens_hsa047401.14263375
43Shigellosis_Homo sapiens_hsa051311.13872792
44Renal cell carcinoma_Homo sapiens_hsa052111.13568878
45Serotonergic synapse_Homo sapiens_hsa047261.10651268
46Taste transduction_Homo sapiens_hsa047421.09755424
47Long-term depression_Homo sapiens_hsa047301.06934537
48Ras signaling pathway_Homo sapiens_hsa040141.06380405
49T cell receptor signaling pathway_Homo sapiens_hsa046601.02378199
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01590051
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01110108
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01097205
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01080915
54Cholinergic synapse_Homo sapiens_hsa047251.00773396
55ABC transporters_Homo sapiens_hsa020100.98447631
56Mineral absorption_Homo sapiens_hsa049780.97408851
57GABAergic synapse_Homo sapiens_hsa047270.96370096
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96031930
59Choline metabolism in cancer_Homo sapiens_hsa052310.95721503
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94210535
61Osteoclast differentiation_Homo sapiens_hsa043800.94023976
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90576936
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.89990992
64Collecting duct acid secretion_Homo sapiens_hsa049660.89085066
65HIF-1 signaling pathway_Homo sapiens_hsa040660.87329719
66Calcium signaling pathway_Homo sapiens_hsa040200.86666759
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.86529018
68Alzheimers disease_Homo sapiens_hsa050100.86421288
69Gap junction_Homo sapiens_hsa045400.80462863
70Salivary secretion_Homo sapiens_hsa049700.79072085
71Fat digestion and absorption_Homo sapiens_hsa049750.78925458
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76066618
73Arachidonic acid metabolism_Homo sapiens_hsa005900.76024216
74Starch and sucrose metabolism_Homo sapiens_hsa005000.75497497
75Focal adhesion_Homo sapiens_hsa045100.74887419
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74091743
77Melanogenesis_Homo sapiens_hsa049160.72738509
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71741217
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70132641
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69220588
81Protein export_Homo sapiens_hsa030600.69141151
82Vitamin digestion and absorption_Homo sapiens_hsa049770.69123994
83Peroxisome_Homo sapiens_hsa041460.66542536
84Parkinsons disease_Homo sapiens_hsa050120.66500991
85Pancreatic secretion_Homo sapiens_hsa049720.66278415
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65759961
87Circadian entrainment_Homo sapiens_hsa047130.64379538
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64275587
89Rap1 signaling pathway_Homo sapiens_hsa040150.64051611
90Renin-angiotensin system_Homo sapiens_hsa046140.64051546
91Graft-versus-host disease_Homo sapiens_hsa053320.63463320
92Tight junction_Homo sapiens_hsa045300.62197072
93Phototransduction_Homo sapiens_hsa047440.61435739
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.61211419
95Estrogen signaling pathway_Homo sapiens_hsa049150.60721359
96Vibrio cholerae infection_Homo sapiens_hsa051100.59763678
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59347134
98Dorso-ventral axis formation_Homo sapiens_hsa043200.58531517
99Arginine and proline metabolism_Homo sapiens_hsa003300.57827988
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.57691835
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56234506
102Endocytosis_Homo sapiens_hsa041440.55485161
103Allograft rejection_Homo sapiens_hsa053300.54693634
104Prostate cancer_Homo sapiens_hsa052150.54002478
105Thyroid hormone synthesis_Homo sapiens_hsa049180.53946287
106Glutathione metabolism_Homo sapiens_hsa004800.53925108
107Pancreatic cancer_Homo sapiens_hsa052120.52861163
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50121791
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49631912
110Asthma_Homo sapiens_hsa053100.49341025
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48682741
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48639322
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48292723
114Fructose and mannose metabolism_Homo sapiens_hsa000510.47714494
115Autoimmune thyroid disease_Homo sapiens_hsa053200.47406040
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46432544
117Mismatch repair_Homo sapiens_hsa034300.46177792
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.45837212
119Leishmaniasis_Homo sapiens_hsa051400.44446250
120Apoptosis_Homo sapiens_hsa042100.44197831
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43350606
122Fatty acid metabolism_Homo sapiens_hsa012120.43215724
123Chemical carcinogenesis_Homo sapiens_hsa052040.43157891
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.42095016
125Viral carcinogenesis_Homo sapiens_hsa052030.42059829
126Propanoate metabolism_Homo sapiens_hsa006400.41680656
127Platelet activation_Homo sapiens_hsa046110.41201464
128Legionellosis_Homo sapiens_hsa051340.40656933
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.40213370
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.39372225
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39265309
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38475561
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.38203832
134Synaptic vesicle cycle_Homo sapiens_hsa047210.37836724
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.37521038
136Endometrial cancer_Homo sapiens_hsa052130.37467730
137Salmonella infection_Homo sapiens_hsa051320.37090141
138Non-small cell lung cancer_Homo sapiens_hsa052230.36612597
139Chemokine signaling pathway_Homo sapiens_hsa040620.36084977
140Amoebiasis_Homo sapiens_hsa051460.35994738
141Prion diseases_Homo sapiens_hsa050200.35800749
142GnRH signaling pathway_Homo sapiens_hsa049120.34510558
143Hepatitis C_Homo sapiens_hsa051600.33079429
144Primary immunodeficiency_Homo sapiens_hsa053400.32260151
145Acute myeloid leukemia_Homo sapiens_hsa052210.31583494
146ECM-receptor interaction_Homo sapiens_hsa045120.29780078
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28513338
148Insulin secretion_Homo sapiens_hsa049110.26785067
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.26508587
150Tryptophan metabolism_Homo sapiens_hsa003800.26375366
151Malaria_Homo sapiens_hsa051440.26158478
152B cell receptor signaling pathway_Homo sapiens_hsa046620.22526927
153Oxytocin signaling pathway_Homo sapiens_hsa049210.21652333
154Phagosome_Homo sapiens_hsa041450.21647678

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