LY6G5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of tolerance induction (GO:0002643)9.91303331
2regulation of chronic inflammatory response (GO:0002676)8.01343056
3heterotypic cell-cell adhesion (GO:0034113)7.39388841
4sperm capacitation (GO:0048240)7.39298247
5kynurenine metabolic process (GO:0070189)6.35127082
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.07298103
7leukocyte aggregation (GO:0070486)6.01294148
8tolerance induction (GO:0002507)5.92282785
9positive regulation of type 2 immune response (GO:0002830)5.84985770
10single fertilization (GO:0007338)5.63337032
11positive regulation of gamma-delta T cell activation (GO:0046645)5.60010071
12negative regulation of interleukin-10 production (GO:0032693)5.44483106
13regulation of type 2 immune response (GO:0002828)5.29230756
14indolalkylamine catabolic process (GO:0046218)5.15936285
15tryptophan catabolic process (GO:0006569)5.15936285
16indole-containing compound catabolic process (GO:0042436)5.15936285
17positive thymic T cell selection (GO:0045059)5.06334673
18negative regulation of type 2 immune response (GO:0002829)5.00945398
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.73170288
20lymphocyte costimulation (GO:0031294)4.71979573
21negative thymic T cell selection (GO:0045060)4.71135197
22T cell costimulation (GO:0031295)4.63668454
23sequestering of actin monomers (GO:0042989)4.62880910
24negative T cell selection (GO:0043383)4.55335312
25thymic T cell selection (GO:0045061)4.53954563
26cellular response to interleukin-15 (GO:0071350)4.50361424
27behavioral response to nicotine (GO:0035095)4.47871789
28regulation of isotype switching to IgG isotypes (GO:0048302)4.44267193
29negative regulation of T cell mediated immunity (GO:0002710)4.26108700
30regulation of gamma-delta T cell activation (GO:0046643)4.26012447
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.19122363
32tryptophan metabolic process (GO:0006568)4.17923006
33regulation of gamma-delta T cell differentiation (GO:0045586)4.11277953
34fucose catabolic process (GO:0019317)4.07013611
35L-fucose metabolic process (GO:0042354)4.07013611
36L-fucose catabolic process (GO:0042355)4.07013611
37response to interleukin-15 (GO:0070672)4.00470586
38positive regulation of CREB transcription factor activity (GO:0032793)3.99710068
39T cell receptor signaling pathway (GO:0050852)3.93953177
40activated T cell proliferation (GO:0050798)3.92015145
41negative regulation of interleukin-8 production (GO:0032717)3.87187118
42positive T cell selection (GO:0043368)3.86483401
43negative regulation of telomere maintenance (GO:0032205)3.85316604
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.84547433
45regulation of B cell receptor signaling pathway (GO:0050855)3.81292691
46T cell selection (GO:0045058)3.69348575
47DNA deamination (GO:0045006)3.67713660
48negative regulation of T cell apoptotic process (GO:0070233)3.62517329
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54410749
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54410749
51defense response to bacterium (GO:0042742)3.52478250
52positive regulation of cellular amide metabolic process (GO:0034250)3.52084889
53antigen processing and presentation via MHC class Ib (GO:0002475)3.51123204
54fertilization (GO:0009566)3.50195099
55positive regulation of defense response to virus by host (GO:0002230)3.49777258
56regulation of defense response to virus by virus (GO:0050690)3.42095375
57antigen receptor-mediated signaling pathway (GO:0050851)3.41461821
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.40488408
59cellular response to type I interferon (GO:0071357)3.38865204
60type I interferon signaling pathway (GO:0060337)3.38865204
61negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.37062937
62response to type I interferon (GO:0034340)3.35615820
63regulation of T cell receptor signaling pathway (GO:0050856)3.34220237
64amine catabolic process (GO:0009310)3.32148200
65cellular biogenic amine catabolic process (GO:0042402)3.32148200
66protein import into peroxisome matrix (GO:0016558)3.26325107
67regulation of respiratory burst (GO:0060263)3.21264423
68negative regulation of immunoglobulin mediated immune response (GO:0002890)3.20830360
69negative regulation of B cell mediated immunity (GO:0002713)3.20830360
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20542639
71negative regulation of cell killing (GO:0031342)3.20542639
72aromatic amino acid family catabolic process (GO:0009074)3.19212222
73negative regulation of mast cell activation (GO:0033004)3.18473131
74regulation of interleukin-13 production (GO:0032656)3.16814970
75negative regulation of adaptive immune response (GO:0002820)3.16637540
76rRNA catabolic process (GO:0016075)3.16117424
77positive regulation of lamellipodium assembly (GO:0010592)3.13141818
78negative regulation of protein oligomerization (GO:0032460)3.11321631
79negative regulation of interleukin-1 beta production (GO:0032691)3.10606953
80positive regulation of cell-cell adhesion (GO:0022409)3.08739059
81negative regulation of interleukin-1 production (GO:0032692)3.07494684
82T cell migration (GO:0072678)3.07204668
83response to bacterium (GO:0009617)3.06402184
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06275372
85adaptation of signaling pathway (GO:0023058)3.04794154
86regulation of immunoglobulin mediated immune response (GO:0002889)3.02389988
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01341741
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.99549917
89regulation of translation, ncRNA-mediated (GO:0045974)2.99549917
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99549917
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98465438
92positive regulation of interleukin-12 production (GO:0032735)2.97423563
93indolalkylamine metabolic process (GO:0006586)2.94559592
94antigen processing and presentation of endogenous antigen (GO:0019883)2.94293586
95cellular response to exogenous dsRNA (GO:0071360)2.93959864
96desmosome organization (GO:0002934)2.93689305
97regulation of B cell mediated immunity (GO:0002712)2.92138799
98negative regulation of leukocyte mediated immunity (GO:0002704)2.91237925
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87984334
100maturation of 5.8S rRNA (GO:0000460)2.87651733
101positive regulation of B cell mediated immunity (GO:0002714)2.86800307
102positive regulation of immunoglobulin mediated immune response (GO:0002891)2.86800307
103regulation of response to interferon-gamma (GO:0060330)2.84344672
104CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84109130
105regulation of activated T cell proliferation (GO:0046006)2.82775827
106regulation of T cell mediated cytotoxicity (GO:0001914)2.80249823
107regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.79248636
108negative regulation of endopeptidase activity (GO:0010951)2.78142338
109regulation of defense response to virus by host (GO:0050691)2.76304607
110positive regulation of histone deacetylation (GO:0031065)2.75455000
111positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75141529
112regulation of mast cell activation (GO:0033003)2.73818518
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73591184
114respiratory burst (GO:0045730)2.71039369
115negative regulation of phagocytosis (GO:0050765)2.70896300
116modulation by symbiont of host immune response (GO:0052553)2.69580961
117positive regulation by symbiont of host defense response (GO:0052509)2.69580961
118modulation by symbiont of host defense response (GO:0052031)2.69580961
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69580961
120modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69580961
121positive regulation by organism of defense response of other organism involved in symbiotic interact2.69580961
122pyrimidine ribonucleoside catabolic process (GO:0046133)2.69506354
123positive regulation of mast cell activation (GO:0033005)2.69361584
124interferon-gamma production (GO:0032609)2.67807371
125regulation of interleukin-10 production (GO:0032653)2.66539375
126digestion (GO:0007586)2.65633850
127positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.64944231
128positive regulation of natural killer cell mediated immunity (GO:0002717)2.64944231
129negative regulation of peptidase activity (GO:0010466)2.64353781
130regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63258396
131regulation of natural killer cell mediated immunity (GO:0002715)2.63258396
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62923006
133response to muramyl dipeptide (GO:0032495)2.62596926
134histone H3-K4 trimethylation (GO:0080182)2.62455137
135negative regulation of alpha-beta T cell activation (GO:0046636)2.61862521
136cytidine metabolic process (GO:0046087)2.61012605
137cytidine catabolic process (GO:0006216)2.61012605
138cytidine deamination (GO:0009972)2.61012605
139mannose metabolic process (GO:0006013)2.57888519
140fucosylation (GO:0036065)2.57762377
141purinergic nucleotide receptor signaling pathway (GO:0035590)2.57557701
142positive regulation of T-helper 1 type immune response (GO:0002827)2.56770620
143cAMP catabolic process (GO:0006198)2.56529159
144regulation of leukocyte mediated cytotoxicity (GO:0001910)2.54376301
145macrophage activation involved in immune response (GO:0002281)2.54296246
146histone H3-K9 modification (GO:0061647)2.53466085
147negative regulation of interleukin-12 production (GO:0032695)2.53134653
148negative regulation of interleukin-6 production (GO:0032715)2.49859298
149defense response to protozoan (GO:0042832)2.48437863
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47025620
151regulation of interferon-beta biosynthetic process (GO:0045357)2.45927897
152response to protozoan (GO:0001562)2.44995831
153cellular response to ATP (GO:0071318)2.43065257
154glycerophospholipid catabolic process (GO:0046475)2.42903859
155negative regulation of innate immune response (GO:0045824)2.42302472
156histone H3-K9 methylation (GO:0051567)2.42135488
157positive regulation of granulocyte differentiation (GO:0030854)2.41325510
158negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40503523
159regulation of nuclear cell cycle DNA replication (GO:0033262)2.40076535
160nucleotide transmembrane transport (GO:1901679)2.39911689
161positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.39280708
162regulation of cell killing (GO:0031341)2.38529175
163regulation of memory T cell differentiation (GO:0043380)2.38493446
164protein-cofactor linkage (GO:0018065)2.38416553
165seminiferous tubule development (GO:0072520)16.4397609
166regulation of T cell tolerance induction (GO:0002664)13.2140042
167positive regulation of tolerance induction (GO:0002645)11.4567038
168production of molecular mediator involved in inflammatory response (GO:0002532)10.5822077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.67745633
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.82154302
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94474233
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.93509826
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.65693619
6ZNF274_21170338_ChIP-Seq_K562_Hela3.52693608
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40926234
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.06894199
9EZH2_22144423_ChIP-Seq_EOC_Human2.92425214
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.80058059
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.73306312
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71963070
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67694985
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.54434003
15RUNX_20019798_ChIP-Seq_JUKART_Human2.42025868
16VDR_22108803_ChIP-Seq_LS180_Human2.41894458
17MYB_26560356_Chip-Seq_TH2_Human2.38601765
18UTX_26944678_Chip-Seq_JUKART_Human2.35244951
19MYB_26560356_Chip-Seq_TH1_Human2.29710606
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28920781
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.23369583
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22070093
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21891375
24MAF_26560356_Chip-Seq_TH1_Human2.20377478
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17710902
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08479270
27* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05442575
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.03229391
29PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.98944177
30EGR1_19032775_ChIP-ChIP_M12_Human1.98578506
31* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96587974
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91196015
33MAF_26560356_Chip-Seq_TH2_Human1.87365744
34MYC_22102868_ChIP-Seq_BL_Human1.86663586
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85980493
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84748385
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84528286
38GATA3_27048872_Chip-Seq_THYMUS_Human1.83507076
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.82811123
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.81579272
41E2F1_20622854_ChIP-Seq_HELA_Human1.78685160
42ERA_21632823_ChIP-Seq_H3396_Human1.77571162
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75676215
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75343838
45* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72179335
46DROSHA_22980978_ChIP-Seq_HELA_Human1.72004325
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.70038255
48SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69748794
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67137919
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64613305
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.64550421
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64141647
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63719928
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.63035709
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62444844
56PHF8_20622854_ChIP-Seq_HELA_Human1.59451371
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.58564659
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57095392
59* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56093312
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56004785
61CIITA_25753668_ChIP-Seq_RAJI_Human1.54279795
62FLI1_21867929_ChIP-Seq_CD8_Mouse1.53976506
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53497852
64VDR_24763502_ChIP-Seq_THP-1_Human1.52231301
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50234184
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48460541
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46595033
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.46084056
69BCL6_27268052_Chip-Seq_Bcells_Human1.45545737
70CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44433949
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43705919
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.43518681
73RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.42635363
74TAF2_19829295_ChIP-Seq_ESCs_Human1.42183108
75SPI1_23547873_ChIP-Seq_NB4_Human1.41464891
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41292260
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40651787
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40574613
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.40222880
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.38656285
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38382207
82FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37023742
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37015792
84RAC3_21632823_ChIP-Seq_H3396_Human1.36312393
85SA1_27219007_Chip-Seq_Bcells_Human1.36143380
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35538590
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34779145
88VDR_21846776_ChIP-Seq_THP-1_Human1.33762519
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.33736809
90OCT4_20526341_ChIP-Seq_ESCs_Human1.30858585
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29532650
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29484740
93NANOG_20526341_ChIP-Seq_ESCs_Human1.29368133
94P68_20966046_ChIP-Seq_HELA_Human1.29288544
95AR_21572438_ChIP-Seq_LNCaP_Human1.28593650
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27670963
97TCF7_22412390_ChIP-Seq_EML_Mouse1.26405226
98REST_21632747_ChIP-Seq_MESCs_Mouse1.26202976
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25843189
100GATA3_21867929_ChIP-Seq_TH1_Mouse1.24173485
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24171181
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23082962
103LXR_22292898_ChIP-Seq_THP-1_Human1.22680263
104OCT4_19829295_ChIP-Seq_ESCs_Human1.22459124
105P300_27268052_Chip-Seq_Bcells_Human1.21070849
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20160592
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18733238
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.18406123
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17794216
110GATA3_26560356_Chip-Seq_TH2_Human1.17059104
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12825811
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12633842
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12347838
114ZNF263_19887448_ChIP-Seq_K562_Human1.11515781
115MYC_19829295_ChIP-Seq_ESCs_Human1.11069775
116CTCF_26484167_Chip-Seq_Bcells_Mouse1.10093294
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10071453
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09810912
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09567960
120P53_21459846_ChIP-Seq_SAOS-2_Human1.09505469
121BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.09170421
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07970977
123ETS1_21867929_ChIP-Seq_TH2_Mouse1.07748861
124IRF1_19129219_ChIP-ChIP_H3396_Human1.07633395
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07385316
126BCOR_27268052_Chip-Seq_Bcells_Human1.05745717
127FOXH1_21741376_ChIP-Seq_ESCs_Human1.05586480
128TP53_22573176_ChIP-Seq_HFKS_Human1.05061586
129CTCF_20526341_ChIP-Seq_ESCs_Human1.04730790
130SCL_19346495_ChIP-Seq_HPC-7_Human1.04610180
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04351641
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03786421
133KDM2B_26808549_Chip-Seq_DND41_Human1.03671224
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03646336
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03562903
136NFE2_27457419_Chip-Seq_LIVER_Mouse1.03420619
137EGR1_19374776_ChIP-ChIP_THP-1_Human1.02896542
138CTCF_27219007_Chip-Seq_Bcells_Human1.02600005
139* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01789848
140ER_23166858_ChIP-Seq_MCF-7_Human1.01531895
141GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99760572
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99020601
143TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98570293
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98197807
145SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98136102
146RACK7_27058665_Chip-Seq_MCF-7_Human0.97921957
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97824386
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97784824
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.97498177
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96953283
151VDR_23849224_ChIP-Seq_CD4+_Human0.96903950
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95533688
153* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95345929
154SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95078709
155ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95025070
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94656936
157CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94169512
158KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93747960
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93296312
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.93116991
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91543343
162TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90874492
163RARB_24833708_ChIP-Seq_LIVER_Mouse0.90753923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.66038021
2MP0003303_peritoneal_inflammation3.98564484
3MP0003763_abnormal_thymus_physiology3.71247282
4MP0009785_altered_susceptibility_to3.31291216
5MP0002933_joint_inflammation3.14050992
6MP0001835_abnormal_antigen_presentation3.08943585
7MP0005000_abnormal_immune_tolerance3.03613923
8MP0000685_abnormal_immune_system2.95678909
9MP0006082_CNS_inflammation2.83269239
10MP0001986_abnormal_taste_sensitivity2.82053443
11MP0002166_altered_tumor_susceptibility2.77119919
12MP0005025_abnormal_response_to2.70204098
13MP0001790_abnormal_immune_system2.61530795
14MP0005387_immune_system_phenotype2.61530795
15MP0010234_abnormal_vibrissa_follicle2.57001776
16MP0001800_abnormal_humoral_immune2.56562507
17MP0001819_abnormal_immune_cell2.50838738
18MP0001853_heart_inflammation2.48653413
19MP0002723_abnormal_immune_serum2.48021783
20MP0003724_increased_susceptibility_to2.45126320
21MP0002420_abnormal_adaptive_immunity2.41930760
22MP0002653_abnormal_ependyma_morphology2.37392431
23MP0002452_abnormal_antigen_presenting2.35206035
24MP0003436_decreased_susceptibility_to2.31160428
25MP0002006_tumorigenesis2.11563174
26MP0002405_respiratory_system_inflammati2.06769285
27MP0002419_abnormal_innate_immunity2.06763425
28MP0003300_gastrointestinal_ulcer2.06164417
29MP0002398_abnormal_bone_marrow2.06014152
30MP0005310_abnormal_salivary_gland2.01589305
31MP0010155_abnormal_intestine_physiology1.99724922
32MP0004947_skin_inflammation1.97567107
33MP0000716_abnormal_immune_system1.97084168
34MP0004381_abnormal_hair_follicle1.96024771
35MP0005058_abnormal_lysosome_morphology1.93885055
36MP0002254_reproductive_system_inflammat1.85915686
37MP0009333_abnormal_splenocyte_physiolog1.85891828
38MP0003195_calcinosis1.83532872
39MP0003448_altered_tumor_morphology1.82191346
40MP0003329_amyloid_beta_deposits1.80735572
41MP0003172_abnormal_lysosome_physiology1.77397246
42MP0000858_altered_metastatic_potential1.76393165
43MP0001845_abnormal_inflammatory_respons1.74972005
44MP0002138_abnormal_hepatobiliary_system1.71776402
45MP0002722_abnormal_immune_system1.69599532
46MP0008877_abnormal_DNA_methylation1.65822157
47MP0000569_abnormal_digit_pigmentation1.58587144
48MP0004510_myositis1.57614139
49MP0000689_abnormal_spleen_morphology1.56278307
50MP0005451_abnormal_body_composition1.54082906
51MP0003646_muscle_fatigue1.52063231
52MP0002429_abnormal_blood_cell1.50277718
53MP0003787_abnormal_imprinting1.50254500
54MP0002148_abnormal_hypersensitivity_rea1.47787575
55MP0000703_abnormal_thymus_morphology1.45963159
56MP0005174_abnormal_tail_pigmentation1.44423901
57MP0001501_abnormal_sleep_pattern1.43556476
58MP0003866_abnormal_defecation1.42776155
59MP0008995_early_reproductive_senescence1.39734800
60MP0004130_abnormal_muscle_cell1.38254282
61MP0001533_abnormal_skeleton_physiology1.38209345
62MP0008469_abnormal_protein_level1.36995271
63MP0003136_yellow_coat_color1.36983678
64MP0003566_abnormal_cell_adhesion1.32847761
65MP0004142_abnormal_muscle_tone1.30878263
66MP0000604_amyloidosis1.30744431
67MP0002277_abnormal_respiratory_mucosa1.30521204
68MP0001851_eye_inflammation1.28844237
69MP0009278_abnormal_bone_marrow1.28033672
70MP0002876_abnormal_thyroid_physiology1.27907375
71MP0008875_abnormal_xenobiotic_pharmacok1.27062343
72MP0001968_abnormal_touch/_nociception1.27008210
73MP0002102_abnormal_ear_morphology1.26244681
74MP0005464_abnormal_platelet_physiology1.25510696
75MP0001873_stomach_inflammation1.24650769
76MP0005410_abnormal_fertilization1.23971634
77MP0001919_abnormal_reproductive_system1.21577128
78MP0009764_decreased_sensitivity_to1.20774149
79MP0001348_abnormal_lacrimal_gland1.20635911
80MP0005551_abnormal_eye_electrophysiolog1.20216491
81MP0005075_abnormal_melanosome_morpholog1.20136938
82MP0000465_gastrointestinal_hemorrhage1.10478869
83MP0003191_abnormal_cellular_cholesterol1.10250837
84MP0008961_abnormal_basal_metabolism1.09670325
85MP0002928_abnormal_bile_duct1.08123791
86MP0005023_abnormal_wound_healing1.08110753
87MP0000343_altered_response_to1.07882062
88MP0000015_abnormal_ear_pigmentation1.07551788
89MP0009763_increased_sensitivity_to1.05701196
90MP0005167_abnormal_blood-brain_barrier1.04295094
91MP0002998_abnormal_bone_remodeling1.00551794
92MP0005645_abnormal_hypothalamus_physiol0.99516147
93MP0001502_abnormal_circadian_rhythm0.98124347
94MP0002796_impaired_skin_barrier0.97499553
95MP0006292_abnormal_olfactory_placode0.96252505
96MP0002132_abnormal_respiratory_system0.95631244
97MP0009745_abnormal_behavioral_response0.94676526
98MP0005448_abnormal_energy_balance0.92049288
99MP0004043_abnormal_pH_regulation0.91516613
100MP0009046_muscle_twitch0.90752103
101MP0004742_abnormal_vestibular_system0.90713697
102MP0000003_abnormal_adipose_tissue0.87949129
103MP0004133_heterotaxia0.86107330
104MP0000470_abnormal_stomach_morphology0.85906432
105MP0002396_abnormal_hematopoietic_system0.84845929
106MP0002089_abnormal_postnatal_growth/wei0.84038930
107MP0002095_abnormal_skin_pigmentation0.83048289
108MP0002638_abnormal_pupillary_reflex0.81910706
109MP0009765_abnormal_xenobiotic_induced0.81906737
110MP0002168_other_aberrant_phenotype0.80472661
111MP0002733_abnormal_thermal_nociception0.80354325
112MP0005389_reproductive_system_phenotype0.79792485
113MP0001216_abnormal_epidermal_layer0.77957113
114MP0001191_abnormal_skin_condition0.77702650
115MP0000249_abnormal_blood_vessel0.77231241
116MP0005423_abnormal_somatic_nervous0.76835022
117MP0005501_abnormal_skin_physiology0.73150165
118MP0009643_abnormal_urine_homeostasis0.72551132
119MP0005166_decreased_susceptibility_to0.72532808
120MP0000631_abnormal_neuroendocrine_gland0.71627075
121MP0001970_abnormal_pain_threshold0.71163623
122MP0005381_digestive/alimentary_phenotyp0.70605097
123MP0002693_abnormal_pancreas_physiology0.69865974
124MP0002064_seizures0.69816832
125MP0002272_abnormal_nervous_system0.69446420
126MP0002572_abnormal_emotion/affect_behav0.69441566
127MP0003795_abnormal_bone_structure0.69211507
128MP0003011_delayed_dark_adaptation0.69202998
129MP0000230_abnormal_systemic_arterial0.68986393
130MP0002136_abnormal_kidney_physiology0.68752815
131MP0002019_abnormal_tumor_incidence0.68490075
132MP0002063_abnormal_learning/memory/cond0.67046062
133MP0005360_urolithiasis0.65634152
134MP0001663_abnormal_digestive_system0.65554843
135MP0001661_extended_life_span0.64907672
136MP0001485_abnormal_pinna_reflex0.63721202
137MP0001881_abnormal_mammary_gland0.63505810
138MP0000477_abnormal_intestine_morphology0.62486083
139MP0005390_skeleton_phenotype0.61768043
140MP0002837_dystrophic_cardiac_calcinosis0.60580831
141MP0000427_abnormal_hair_cycle0.58967232
142MP0003959_abnormal_lean_body0.58016183
143MP0005375_adipose_tissue_phenotype0.57653526
144MP0008872_abnormal_physiological_respon0.54350414
145MP0000609_abnormal_liver_physiology0.53899396
146MP0003453_abnormal_keratinocyte_physiol0.52271209
147MP0002909_abnormal_adrenal_gland0.50746127
148MP0001765_abnormal_ion_homeostasis0.50420056
149MP0001764_abnormal_homeostasis0.49844692
150MP0002139_abnormal_hepatobiliary_system0.49698684
151MP0005636_abnormal_mineral_homeostasis0.47633044

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)6.46143931
2Elevated erythrocyte sedimentation rate (HP:0003565)6.04030037
3Recurrent bronchitis (HP:0002837)5.69989362
4Eczematoid dermatitis (HP:0000976)5.30958295
5Abnormality of B cell number (HP:0010975)4.82812106
6B lymphocytopenia (HP:0010976)4.82812106
7IgG deficiency (HP:0004315)4.74812164
8Severe combined immunodeficiency (HP:0004430)4.57746055
9Myositis (HP:0100614)4.57002722
10T lymphocytopenia (HP:0005403)4.39598708
11Stomatitis (HP:0010280)4.34909580
12Abnormality of T cell number (HP:0011839)4.28319609
13Combined immunodeficiency (HP:0005387)4.23121631
14Pustule (HP:0200039)3.91693227
15Abnormality of T cells (HP:0002843)3.87301423
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.79420814
17Reduced subcutaneous adipose tissue (HP:0003758)3.77644278
18Increased IgM level (HP:0003496)3.76126603
19Recurrent sinusitis (HP:0011108)3.74221777
20Congenital stationary night blindness (HP:0007642)3.73023403
21Recurrent gram-negative bacterial infections (HP:0005420)3.69348147
22Recurrent abscess formation (HP:0002722)3.65315347
23IgA deficiency (HP:0002720)3.54812790
24Lymphopenia (HP:0001888)3.46711234
25Gastrointestinal stroma tumor (HP:0100723)3.46422078
26Abnormality of macrophages (HP:0004311)3.40016501
27Abnormality of T cell physiology (HP:0011840)3.33479140
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.31488936
29Molar tooth sign on MRI (HP:0002419)3.28155377
30Abnormality of midbrain morphology (HP:0002418)3.28155377
31Recurrent fungal infections (HP:0002841)3.28147184
32Bronchitis (HP:0012387)3.27071993
33Pancreatic cysts (HP:0001737)3.25881408
34Stomach cancer (HP:0012126)3.17727587
35Polydipsia (HP:0001959)3.16237449
36Abnormal drinking behavior (HP:0030082)3.16237449
37Orchitis (HP:0100796)3.16201764
38Chronic mucocutaneous candidiasis (HP:0002728)3.14738459
39Recurrent cutaneous fungal infections (HP:0011370)3.14738459
40Chronic obstructive pulmonary disease (HP:0006510)3.11911151
41Obstructive lung disease (HP:0006536)3.11911151
42Vasculitis (HP:0002633)3.08239156
43Neoplasm of the heart (HP:0100544)3.07228962
44Erythema (HP:0010783)3.02805376
45Myocardial infarction (HP:0001658)3.01886413
46Vacuolated lymphocytes (HP:0001922)3.00287445
47Abnormality of eosinophils (HP:0001879)2.97175992
48Retrobulbar optic neuritis (HP:0100654)2.94383239
49Optic neuritis (HP:0100653)2.94383239
50Hypoplasia of the thymus (HP:0000778)2.93402063
51Recurrent bacterial skin infections (HP:0005406)2.88517901
52Thyroiditis (HP:0100646)2.85107820
53Hypergammaglobulinemia (HP:0010702)2.84575549
54Type II lissencephaly (HP:0007260)2.84209683
55Hypochromic anemia (HP:0001931)2.83021975
56Abnormality of the renal cortex (HP:0011035)2.79549457
57Hypophosphatemic rickets (HP:0004912)2.76131011
58Recurrent skin infections (HP:0001581)2.73469918
59Nephronophthisis (HP:0000090)2.71426133
60Brushfield spots (HP:0001088)2.71181425
61Large for gestational age (HP:0001520)2.69835012
62Nasal polyposis (HP:0100582)2.69217565
63Gingivitis (HP:0000230)2.68958948
64Chronic diarrhea (HP:0002028)2.68815717
65Recurrent otitis media (HP:0000403)2.67723317
66Tubular atrophy (HP:0000092)2.65661433
67Attenuation of retinal blood vessels (HP:0007843)2.65546464
68Polar cataract (HP:0010696)2.64210958
69Leukocytosis (HP:0001974)2.63964993
70Pancreatic fibrosis (HP:0100732)2.63462674
71Emphysema (HP:0002097)2.56760943
72Genetic anticipation (HP:0003743)2.55624422
73Dry hair (HP:0011359)2.53579461
74Rib fusion (HP:0000902)2.52526064
75Amyotrophic lateral sclerosis (HP:0007354)2.52357404
76Urticaria (HP:0001025)2.48362111
77Mediastinal lymphadenopathy (HP:0100721)2.48290618
78Encephalitis (HP:0002383)2.45939621
79Autoimmune hemolytic anemia (HP:0001890)2.41116984
80Panhypogammaglobulinemia (HP:0003139)2.38397883
81Joint swelling (HP:0001386)2.38242851
82Abnormality of the renal medulla (HP:0100957)2.37599571
83Inability to walk (HP:0002540)2.37012313
84Hyperventilation (HP:0002883)2.35492092
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.34959517
86Abnormality of the pons (HP:0007361)2.34504026
87Pulmonary infiltrates (HP:0002113)2.33692727
88Cystic liver disease (HP:0006706)2.32681077
89Chronic otitis media (HP:0000389)2.32465333
90True hermaphroditism (HP:0010459)2.31261084
91Anorexia (HP:0002039)2.29759408
92Abnormality of the nasal mucosa (HP:0000433)2.29503382
93Skin rash (HP:0000988)2.29021498
94Chronic hepatic failure (HP:0100626)2.27286432
95Progressive cerebellar ataxia (HP:0002073)2.26835767
96Increased density of long bones (HP:0006392)2.26832067
97Hemoptysis (HP:0002105)2.25571168
98Polyuria (HP:0000103)2.25125805
99Protruding tongue (HP:0010808)2.25070621
100Patellar aplasia (HP:0006443)2.19757779
101Severe muscular hypotonia (HP:0006829)2.19411429
102Bile duct proliferation (HP:0001408)2.19290692
103Abnormal biliary tract physiology (HP:0012439)2.19290692
104Asplenia (HP:0001746)2.18468200
105Abnormal rod and cone electroretinograms (HP:0008323)2.17442433
106Duplicated collecting system (HP:0000081)2.17000821
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13747210
108Hypoplasia of the pons (HP:0012110)2.12812432
109Meningitis (HP:0001287)2.12424123
110Clumsiness (HP:0002312)2.11954528
111Microcytic anemia (HP:0001935)2.10907198
112Gastrointestinal infarctions (HP:0005244)2.08446168
113Pendular nystagmus (HP:0012043)2.07797557
114Progressive inability to walk (HP:0002505)2.07720264
115Nuclear cataract (HP:0100018)2.07431657
116Hypertriglyceridemia (HP:0002155)2.07242836
117Abnormality of transition element cation homeostasis (HP:0011030)2.07078555
118Recurrent pneumonia (HP:0006532)2.07019947
119Optic nerve coloboma (HP:0000588)2.05121524
120Large eyes (HP:0001090)2.04768925
121Increased serum ferritin (HP:0003281)2.04470838
122Abnormality of the renal collecting system (HP:0004742)2.04024069
123Eosinophilia (HP:0001880)2.03920873
124Cerebellar dysplasia (HP:0007033)2.02622554
125Keratoconjunctivitis sicca (HP:0001097)2.02597291
126Restrictive lung disease (HP:0002091)2.02254775
127Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01787327
128Lissencephaly (HP:0001339)1.98987443
129Basal cell carcinoma (HP:0002671)1.98292715
130Arthralgia (HP:0002829)1.98029858
131Aplasia/Hypoplasia of the patella (HP:0006498)1.97363266
132Cheilitis (HP:0100825)1.96284074
133Abolished electroretinogram (ERG) (HP:0000550)1.95993587
134Decreased circulating renin level (HP:0003351)1.95884689
135Mesangial abnormality (HP:0001966)1.94716903
136Agammaglobulinemia (HP:0004432)1.93063793
137Autoimmune thrombocytopenia (HP:0001973)1.92963697
138Increased IgE level (HP:0003212)1.91879651
139Gangrene (HP:0100758)1.91075555
140Conical tooth (HP:0000698)1.90100668
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89368461
142Abnormality of iron homeostasis (HP:0011031)1.88677271
143Hypoplastic iliac wings (HP:0002866)1.86367406
144Granulocytopenia (HP:0001913)1.86008550
145Hepatosplenomegaly (HP:0001433)1.85795353
146Abnormality of the lumbar spine (HP:0100712)1.85123264
147Renal cortical cysts (HP:0000803)1.84900001
148Abnormal number of erythroid precursors (HP:0012131)1.83910061
149Abnormal urine output (HP:0012590)1.83772570
150Keratitis (HP:0000491)1.82600362
151Flat occiput (HP:0005469)1.82119153
152Alveolar cell carcinoma (HP:0006519)1.81820097
153Abnormality of DNA repair (HP:0003254)1.81590291
154Lymphoma (HP:0002665)1.80526765
155Vascular calcification (HP:0004934)1.79629937
156Skin ulcer (HP:0200042)1.78756827
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78489437
158Supernumerary bones of the axial skeleton (HP:0009144)1.78317521
159Bony spicule pigmentary retinopathy (HP:0007737)1.78173849
160Choroideremia (HP:0001139)1.77747716
161Sepsis (HP:0100806)1.76600675
162Prominent nose (HP:0000448)1.76370460
163Entropion (HP:0000621)1.75889740
164Abnormal albumin level (HP:0012116)1.75833877
165Hypoalbuminemia (HP:0003073)1.75833877
166Keratoconjunctivitis (HP:0001096)1.75215455
167Pulmonary embolism (HP:0002204)1.74533997
168Absent thumb (HP:0009777)1.71351154
169Impulsivity (HP:0100710)1.70760222
170Arterial thrombosis (HP:0004420)1.70545747
171Chest pain (HP:0100749)1.69184656
172Cellulitis (HP:0100658)1.68364945
173Macroglossia (HP:0000158)1.68000815
174Bulbous nose (HP:0000414)1.67186133
175Birth length less than 3rd percentile (HP:0003561)1.66538217
176Hypoproteinemia (HP:0003075)1.64402985
177Abnormal platelet volume (HP:0011876)1.63256191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.58758133
2TXK4.20575579
3MAP3K124.13463317
4MAP4K13.57136602
5FGFR43.41498985
6TESK23.31074008
7BLK3.22836061
8ZAP703.13920864
9ADRBK22.89393822
10WNK42.56630478
11FRK2.52666240
12TBK12.35137666
13IRAK42.32831456
14ITK2.32535066
15TESK12.28876464
16MAP2K62.25700938
17ERN12.24337793
18IKBKE2.21105582
19MST42.06852917
20EPHB11.90075652
21LCK1.86567221
22CSK1.79153829
23LRRK21.76597889
24BTK1.73378382
25MYLK1.72188588
26TYK21.68999370
27FGFR31.68982895
28HCK1.64617216
29DAPK21.58940977
30SYK1.58342797
31MAPK151.57663525
32STK101.54619819
33MAP4K21.51050324
34CAMKK21.50282065
35TNK21.48259171
36INSRR1.46133858
37MAP3K71.45806947
38TEC1.43498944
39CAMKK11.42936936
40PASK1.38557263
41BMPR1B1.31873470
42SIK11.30626136
43LIMK11.24469881
44MAP2K31.24342888
45JAK11.23492958
46MAPK131.22941196
47GRK61.22452753
48FGFR21.21931581
49JAK31.15794581
50GRK11.13445162
51ILK1.12059142
52CSNK1G21.11700237
53WNK31.08563619
54MAP3K111.06342427
55MAP3K141.03080859
56CHUK1.01762545
57PRKD21.01523534
58MAP3K131.01172060
59FGFR11.00984367
60PKN20.99845452
61MARK20.97581403
62MAP2K20.97068645
63PINK10.91101442
64TAOK30.90249677
65INSR0.89666638
66FYN0.88887269
67SIK20.88495100
68ADRBK10.86124600
69PAK40.85854021
70CDC42BPA0.85152765
71STK110.84364365
72PRKCH0.83102974
73MAPK120.82872602
74STK240.82636450
75IRAK30.81567939
76RPS6KA60.79101462
77ZAK0.78327427
78TLK10.77832691
79PRKCQ0.77823556
80MATK0.76813098
81ROCK10.76344157
82LYN0.75927345
83HIPK20.74975806
84TRIB30.73516922
85TAOK10.73472679
86WNK10.72510666
87SIK30.72370306
88MAPK70.72297242
89KIT0.71395425
90MAPKAPK50.70633993
91NUAK10.69926690
92DAPK30.68828241
93MAPK110.68101702
94EPHA20.67434725
95DMPK0.65403221
96PTK2B0.65193282
97CSNK1G30.63318289
98CSNK1A1L0.60976335
99PAK30.59880386
100MUSK0.58761475
101MAP2K40.58647847
102CAMK1D0.58512603
103EIF2AK30.57553657
104PDGFRB0.57424507
105MAPKAPK30.56610248
106DYRK20.55311112
107FES0.54280247
108FGR0.54106021
109NME10.53619071
110TGFBR10.52168260
111PRKD10.51773007
112BCKDK0.50392440
113CDK40.50016517
114GRK70.49922368
115IRAK20.49656149
116TYRO30.49560789
117RIPK40.49471579
118PRKCZ0.46474844
119PRKCG0.46391819
120CSNK1G10.46282626
121IGF1R0.46005764
122CAMK40.45870624
123FER0.45796662
124MKNK20.45298004
125CDK190.44841737
126MAP3K40.42744554
127CAMK10.42678186
128PRKAA20.42014600
129PRKG20.41912719
130SRC0.40962303
131RET0.40376250
132OXSR10.40337409
133ALK0.39685703
134ACVR1B0.39394852
135RPS6KL10.38560649
136RPS6KC10.38560649
137PTK20.37463465
138PRKCD0.36465431
139IKBKB0.36134481
140TGFBR20.36118082
141ABL10.33368887
142IRAK10.33263057
143PDK10.31661740
144MARK30.31547471
145MAPKAPK20.30691670
146NME20.29839133
147NLK0.28371392
148NEK20.27707035
149NTRK20.27028103
150JAK20.26135951
151ROCK20.24720433
152CSF1R0.23834832
153EGFR0.23748203
154TTN0.23391398
155PDGFRA0.21496307
156DAPK10.21023323
157CDK60.19013265
158LMTK20.17744788
159MAPK30.15987054

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.71816872
2T cell receptor signaling pathway_Homo sapiens_hsa046603.73956128
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.46351300
4Autoimmune thyroid disease_Homo sapiens_hsa053203.31339461
5Glutathione metabolism_Homo sapiens_hsa004803.02864210
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.90618363
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.65090595
8Measles_Homo sapiens_hsa051622.59966000
9Arachidonic acid metabolism_Homo sapiens_hsa005902.53970300
10African trypanosomiasis_Homo sapiens_hsa051432.51665743
11Linoleic acid metabolism_Homo sapiens_hsa005912.39273860
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.23919391
13Allograft rejection_Homo sapiens_hsa053302.22023703
14Leishmaniasis_Homo sapiens_hsa051402.08631172
15Antigen processing and presentation_Homo sapiens_hsa046122.08147192
16Type I diabetes mellitus_Homo sapiens_hsa049402.07326233
17Thyroid hormone synthesis_Homo sapiens_hsa049182.06985432
18Nitrogen metabolism_Homo sapiens_hsa009102.01791404
19Hematopoietic cell lineage_Homo sapiens_hsa046401.99992189
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.91740199
21Graft-versus-host disease_Homo sapiens_hsa053321.82448888
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.81297644
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81009757
24Ether lipid metabolism_Homo sapiens_hsa005651.79236498
25Osteoclast differentiation_Homo sapiens_hsa043801.56895449
26Asthma_Homo sapiens_hsa053101.56296406
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54361519
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54285263
29Tryptophan metabolism_Homo sapiens_hsa003801.49471735
30Staphylococcus aureus infection_Homo sapiens_hsa051501.45275805
31Phototransduction_Homo sapiens_hsa047441.44992787
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41609898
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39885460
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39745624
35ABC transporters_Homo sapiens_hsa020101.38162839
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32464798
37Viral myocarditis_Homo sapiens_hsa054161.28661875
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26598362
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24613023
40Shigellosis_Homo sapiens_hsa051311.23564234
41B cell receptor signaling pathway_Homo sapiens_hsa046621.22213272
42Selenocompound metabolism_Homo sapiens_hsa004501.17976335
43Hepatitis C_Homo sapiens_hsa051601.13090734
44VEGF signaling pathway_Homo sapiens_hsa043701.12683614
45Morphine addiction_Homo sapiens_hsa050321.12368631
46Herpes simplex infection_Homo sapiens_hsa051681.10790510
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.10461553
48Lysosome_Homo sapiens_hsa041421.08404271
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07329517
50Sulfur relay system_Homo sapiens_hsa041221.07031563
51Proteasome_Homo sapiens_hsa030501.06991534
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06891022
53Protein export_Homo sapiens_hsa030601.06287492
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06236214
55Ribosome_Homo sapiens_hsa030101.04743194
56Nicotine addiction_Homo sapiens_hsa050331.03644484
57Chemokine signaling pathway_Homo sapiens_hsa040621.02945753
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.90069981
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88524723
60Fanconi anemia pathway_Homo sapiens_hsa034600.88445226
61Butanoate metabolism_Homo sapiens_hsa006500.88118212
62Homologous recombination_Homo sapiens_hsa034400.87616898
63Tuberculosis_Homo sapiens_hsa051520.85933071
64Ovarian steroidogenesis_Homo sapiens_hsa049130.85349536
65Salmonella infection_Homo sapiens_hsa051320.83226192
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.81773065
67Taste transduction_Homo sapiens_hsa047420.81271925
68RNA degradation_Homo sapiens_hsa030180.80162924
69Toxoplasmosis_Homo sapiens_hsa051450.79975509
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79653665
71Glycerolipid metabolism_Homo sapiens_hsa005610.77364363
72RNA polymerase_Homo sapiens_hsa030200.76328369
73MAPK signaling pathway_Homo sapiens_hsa040100.75370132
74Dorso-ventral axis formation_Homo sapiens_hsa043200.74463481
75Hepatitis B_Homo sapiens_hsa051610.73880246
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72100383
77Olfactory transduction_Homo sapiens_hsa047400.71504456
78Other glycan degradation_Homo sapiens_hsa005110.71482314
79Platelet activation_Homo sapiens_hsa046110.70237855
80Influenza A_Homo sapiens_hsa051640.67764667
81Malaria_Homo sapiens_hsa051440.65237939
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64376210
83Legionellosis_Homo sapiens_hsa051340.63583419
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60162781
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58897790
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57001692
87Caffeine metabolism_Homo sapiens_hsa002320.56332557
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55356777
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55292669
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.54834909
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54690703
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.53371874
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.51257938
94Pertussis_Homo sapiens_hsa051330.51068766
95Viral carcinogenesis_Homo sapiens_hsa052030.49534031
96Vitamin digestion and absorption_Homo sapiens_hsa049770.49428258
97Serotonergic synapse_Homo sapiens_hsa047260.49250318
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.49226193
99HTLV-I infection_Homo sapiens_hsa051660.49119758
100Insulin secretion_Homo sapiens_hsa049110.48536281
101Type II diabetes mellitus_Homo sapiens_hsa049300.47863057
102Fatty acid degradation_Homo sapiens_hsa000710.46111388
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45629523
104Basal transcription factors_Homo sapiens_hsa030220.45013118
105Apoptosis_Homo sapiens_hsa042100.44891074
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44254405
107TNF signaling pathway_Homo sapiens_hsa046680.43757252
108Calcium signaling pathway_Homo sapiens_hsa040200.43294604
109Lysine degradation_Homo sapiens_hsa003100.43185681
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41665983
111Pancreatic cancer_Homo sapiens_hsa052120.41608457
112One carbon pool by folate_Homo sapiens_hsa006700.41147586
113Pentose phosphate pathway_Homo sapiens_hsa000300.40143191
114Glutamatergic synapse_Homo sapiens_hsa047240.39823520
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39536531
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39502999
117Endocytosis_Homo sapiens_hsa041440.38652838
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38547459
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38397984
120Complement and coagulation cascades_Homo sapiens_hsa046100.35714809
121Regulation of autophagy_Homo sapiens_hsa041400.35384940
122Rheumatoid arthritis_Homo sapiens_hsa053230.31741929
123PPAR signaling pathway_Homo sapiens_hsa033200.29371035
124Epstein-Barr virus infection_Homo sapiens_hsa051690.26830387
125Rap1 signaling pathway_Homo sapiens_hsa040150.26171434
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24699703
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22827113
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22485099
129Fatty acid metabolism_Homo sapiens_hsa012120.21175287
130Starch and sucrose metabolism_Homo sapiens_hsa005000.17094466
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17087473
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15572977
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13897876
134Acute myeloid leukemia_Homo sapiens_hsa052210.13070625
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11784346
136Phagosome_Homo sapiens_hsa041450.11494536
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.11272897
138Salivary secretion_Homo sapiens_hsa049700.10672813
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10391620
140Inositol phosphate metabolism_Homo sapiens_hsa005620.09633133
141Estrogen signaling pathway_Homo sapiens_hsa049150.08923763
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07305790
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.07304608

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