LUZP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.31755943
2regulation of meiosis I (GO:0060631)9.31354413
3meiotic nuclear division (GO:0007126)8.26537983
4chromosome organization involved in meiosis (GO:0070192)7.85930308
5meiotic chromosome segregation (GO:0045132)6.63914130
6male meiosis I (GO:0007141)6.58146636
7oogenesis (GO:0048477)6.12163819
8gene silencing by RNA (GO:0031047)6.11147947
9reciprocal meiotic recombination (GO:0007131)5.95148878
10reciprocal DNA recombination (GO:0035825)5.95148878
11positive regulation of meiosis (GO:0045836)5.93755895
12DNA alkylation (GO:0006305)5.91491156
13DNA methylation (GO:0006306)5.91491156
14meiotic cell cycle process (GO:1903046)5.64221782
15regulation of meiotic cell cycle (GO:0051445)5.51866107
16meiosis I (GO:0007127)5.51713685
17positive regulation of meiotic cell cycle (GO:0051446)5.49890974
18negative regulation of meiosis (GO:0045835)5.17001894
19nuclear pore complex assembly (GO:0051292)5.14857205
20mitotic sister chromatid cohesion (GO:0007064)5.13179628
21nuclear pore organization (GO:0006999)5.12683316
22kinetochore organization (GO:0051383)4.93654681
23kinetochore assembly (GO:0051382)4.91946539
24attachment of spindle microtubules to kinetochore (GO:0008608)4.88415516
25sister chromatid cohesion (GO:0007062)4.83147273
26DNA replication checkpoint (GO:0000076)4.80893332
27negative regulation of meiotic cell cycle (GO:0051447)4.78690942
28heterochromatin organization (GO:0070828)4.71870622
29positive regulation of translational initiation (GO:0045948)4.71333142
30germ cell migration (GO:0008354)4.62759670
31resolution of meiotic recombination intermediates (GO:0000712)4.55214707
32DNA methylation or demethylation (GO:0044728)4.52693554
33regulation of double-strand break repair via homologous recombination (GO:0010569)4.51121089
34ribosomal small subunit assembly (GO:0000028)4.47014284
35female gamete generation (GO:0007292)4.40027277
36meiotic cell cycle (GO:0051321)4.35049613
37oocyte maturation (GO:0001556)4.32689108
38gene silencing (GO:0016458)4.32370991
39folic acid transport (GO:0015884)4.26177244
40ncRNA 3-end processing (GO:0043628)4.24027219
41DNA synthesis involved in DNA repair (GO:0000731)4.22333933
42proteasome assembly (GO:0043248)4.15763621
43oocyte development (GO:0048599)4.10116172
44negative regulation of gene silencing (GO:0060969)4.08188439
45pore complex assembly (GO:0046931)3.92972528
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.89940882
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.89940882
48regulation of DNA endoreduplication (GO:0032875)3.85877216
49histone H4-K12 acetylation (GO:0043983)3.85387231
50negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.80743867
51synapsis (GO:0007129)3.77953951
52mitotic chromosome condensation (GO:0007076)3.75780887
53regulation of meiosis (GO:0040020)3.74345843
54metaphase plate congression (GO:0051310)3.73131676
55regulation of double-strand break repair (GO:2000779)3.72976987
56regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.69525008
57DNA modification (GO:0006304)3.67258221
58germ cell development (GO:0007281)3.63810164
59mitotic spindle assembly checkpoint (GO:0007094)3.61207083
60nucleotide transmembrane transport (GO:1901679)3.60089830
61negative regulation of chromosome segregation (GO:0051985)3.59155585
62formation of translation preinitiation complex (GO:0001731)3.58944574
63CENP-A containing nucleosome assembly (GO:0034080)3.58457014
64mitotic metaphase plate congression (GO:0007080)3.57789617
65spindle assembly checkpoint (GO:0071173)3.56312021
66chromatin remodeling at centromere (GO:0031055)3.56240859
67mitotic spindle checkpoint (GO:0071174)3.55657663
68negative regulation of mitotic sister chromatid separation (GO:2000816)3.55270989
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55270989
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55270989
71negative regulation of sister chromatid segregation (GO:0033046)3.55270989
72DNA replication-dependent nucleosome assembly (GO:0006335)3.53173833
73DNA replication-dependent nucleosome organization (GO:0034723)3.53173833
74DNA catabolic process, exonucleolytic (GO:0000738)3.52542369
75regulation of chromosome segregation (GO:0051983)3.46270023
76melanin biosynthetic process (GO:0042438)3.42978911
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.42899516
78embryonic foregut morphogenesis (GO:0048617)3.38612903
79negative regulation of cell cycle G2/M phase transition (GO:1902750)3.38593048
80fusion of sperm to egg plasma membrane (GO:0007342)3.38357683
81N-terminal protein amino acid acetylation (GO:0006474)3.36424375
82spermatid development (GO:0007286)3.35226322
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33823030
84protein K6-linked ubiquitination (GO:0085020)3.33362750
85chromosome organization (GO:0051276)3.33180329
86regulation of mitotic spindle checkpoint (GO:1903504)3.32935410
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32935410
88positive regulation of male gonad development (GO:2000020)3.32443907
89spindle checkpoint (GO:0031577)3.29737590
90negative regulation of nuclear division (GO:0051784)3.28250322
91regulation of mitotic sister chromatid separation (GO:0010965)3.25825360
92regulation of mitotic sister chromatid segregation (GO:0033047)3.25825360
93regulation of sister chromatid segregation (GO:0033045)3.25825360
94regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24750709
95telomere maintenance via telomerase (GO:0007004)3.23130646
96microtubule depolymerization (GO:0007019)3.21994838
97DNA unwinding involved in DNA replication (GO:0006268)3.19491187
98inner cell mass cell proliferation (GO:0001833)3.19377835
99lymphangiogenesis (GO:0001946)3.18736995
100snRNA processing (GO:0016180)3.18118516
101mRNA export from nucleus (GO:0006406)3.14253542
102male sex determination (GO:0030238)3.13549434
103histone exchange (GO:0043486)3.13438008
104pre-miRNA processing (GO:0031054)3.12857537
105regulation of centriole replication (GO:0046599)3.10781218
106nuclear division (GO:0000280)3.10455297
107male gamete generation (GO:0048232)3.10381622
108DNA replication-independent nucleosome organization (GO:0034724)3.10106215
109DNA replication-independent nucleosome assembly (GO:0006336)3.10106215
110spermatogenesis (GO:0007283)3.10004476
111sex differentiation (GO:0007548)3.07841596
112regulation of posttranscriptional gene silencing (GO:0060147)3.06484155
113regulation of gene silencing by miRNA (GO:0060964)3.06484155
114regulation of gene silencing by RNA (GO:0060966)3.06484155
115acrosome reaction (GO:0007340)3.05056774
116binding of sperm to zona pellucida (GO:0007339)3.03992843
117RNA export from nucleus (GO:0006405)3.03546117
118melanin metabolic process (GO:0006582)3.01893534
119snRNA metabolic process (GO:0016073)3.00214630
120positive regulation of catenin import into nucleus (GO:0035413)2.98851952
121negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.98110938
122regulation of histone H3-K9 methylation (GO:0051570)2.97396246
123regulation of translational initiation (GO:0006446)2.93582564
124negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89139014
125blastocyst development (GO:0001824)2.85331699
126embryonic body morphogenesis (GO:0010172)2.82051294
127protein maturation by protein folding (GO:0022417)2.76891319
128negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.70309641
129negative regulation of potassium ion transmembrane transport (GO:1901380)2.69805780
130mesenchyme development (GO:0060485)2.66553623
131telomere maintenance via semi-conservative replication (GO:0032201)2.66256106
132seminiferous tubule development (GO:0072520)2.65712020
133negative regulation of cell division (GO:0051782)2.64147828
134intra-S DNA damage checkpoint (GO:0031573)2.62633356
135plasma membrane fusion (GO:0045026)2.61202173
136piRNA metabolic process (GO:0034587)14.8544025
137gonadal mesoderm development (GO:0007506)14.2881831
138DNA methylation involved in gamete generation (GO:0043046)12.1646277
139synaptonemal complex assembly (GO:0007130)11.3572581
140synaptonemal complex organization (GO:0070193)10.3801872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89051585
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.87097271
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.86181252
4IGF1R_20145208_ChIP-Seq_DFB_Human4.71073371
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.55239196
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.93299707
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85139170
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.45756466
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.30747824
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.11765377
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.77503701
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.73799222
13ZNF274_21170338_ChIP-Seq_K562_Hela2.71689519
14AR_21909140_ChIP-Seq_LNCAP_Human2.65896205
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.57239597
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39868296
17RNF2_27304074_Chip-Seq_NSC_Mouse2.34675411
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.26541535
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.26541535
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.26541535
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15946078
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.15049134
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10887747
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.10624005
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04633319
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96855763
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94368028
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94035694
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93030125
30VDR_22108803_ChIP-Seq_LS180_Human1.89285031
31* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85718518
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78277418
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69737871
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68413273
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.60283913
36DCP1A_22483619_ChIP-Seq_HELA_Human1.57787456
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57516251
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53736376
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49850503
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46504627
41XRN2_22483619_ChIP-Seq_HELA_Human1.42194081
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41047524
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39005247
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37889045
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.37600994
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35088569
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.34878774
48ZNF263_19887448_ChIP-Seq_K562_Human1.34235030
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32334636
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30244373
51RUNX1_26923725_Chip-Seq_HPCs_Mouse1.27429597
52KDM5A_27292631_Chip-Seq_BREAST_Human1.27351357
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25383752
54MYC_18940864_ChIP-ChIP_HL60_Human1.23823830
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23170718
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18316953
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18043644
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.17774589
59VDR_23849224_ChIP-Seq_CD4+_Human1.14824984
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13794060
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09895402
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05976651
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05144040
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.04275227
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03394819
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03314246
67GABP_19822575_ChIP-Seq_HepG2_Human1.03284767
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.03120418
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02833050
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02464520
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01941120
72FOXP3_21729870_ChIP-Seq_TREG_Human1.00186330
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99821461
74TAF15_26573619_Chip-Seq_HEK293_Human0.97349827
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96823024
76GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95946792
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.95759175
78TP63_19390658_ChIP-ChIP_HaCaT_Human0.95758955
79SOX17_20123909_ChIP-Seq_XEN_Mouse0.95624347
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94882401
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94720261
82HTT_18923047_ChIP-ChIP_STHdh_Human0.94613830
83EWS_26573619_Chip-Seq_HEK293_Human0.93370639
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93170581
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.92392872
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91728291
87IRF1_19129219_ChIP-ChIP_H3396_Human0.89477493
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88828717
89* CBX2_27304074_Chip-Seq_ESCs_Mouse0.88748073
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87106585
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86391588
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.85224484
93REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85008381
94THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84346396
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.84213237
96GATA3_21867929_ChIP-Seq_TH1_Mouse0.83850515
97TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83492162
98FUS_26573619_Chip-Seq_HEK293_Human0.83017700
99TTF2_22483619_ChIP-Seq_HELA_Human0.82742628
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82280656
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81725573
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81710314
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81064669
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81032881
105E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80127377
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79466470
107FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79366323
108GATA3_26560356_Chip-Seq_TH1_Human0.78815873
109BCAT_22108803_ChIP-Seq_LS180_Human0.78807505
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78340379
111NANOG_16518401_ChIP-PET_MESCs_Mouse0.78253778
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78212002
113ELK1_19687146_ChIP-ChIP_HELA_Human0.77705149
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72541844
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72472778
116FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.72042445
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.69867447
118TFEB_21752829_ChIP-Seq_HELA_Human0.69507116
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.69432765
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.66625517
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65602619
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64056529
123KLF4_18555785_Chip-Seq_ESCs_Mouse0.63259959
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.62593277
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.60327725
126CIITA_25753668_ChIP-Seq_RAJI_Human0.60218897
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.59923427
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.59398499
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.58633831
130NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.58469806
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.58409322
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.58104546
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57831441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.99487666
2MP0008995_early_reproductive_senescence6.72366323
3MP0010368_abnormal_lymphatic_system5.82400439
4MP0003786_premature_aging4.25451214
5MP0002210_abnormal_sex_determination4.24354564
6MP0010094_abnormal_chromosome_stability4.07279796
7MP0001929_abnormal_gametogenesis3.44875119
8MP0008058_abnormal_DNA_repair3.42550550
9MP0001145_abnormal_male_reproductive3.37342083
10MP0003123_paternal_imprinting3.13543198
11MP0008260_abnormal_autophagy3.13321096
12MP0004147_increased_porphyrin_level3.03656305
13MP0000653_abnormal_sex_gland3.02059775
14MP0003111_abnormal_nucleus_morphology2.83480696
15MP0001188_hyperpigmentation2.82824231
16MP0003698_abnormal_male_reproductive2.82595736
17MP0005171_absent_coat_pigmentation2.58006097
18MP0005174_abnormal_tail_pigmentation2.55854176
19MP0000372_irregular_coat_pigmentation2.37093527
20MP0003693_abnormal_embryo_hatching2.36427789
21MP0004957_abnormal_blastocyst_morpholog2.32006679
22MP0003077_abnormal_cell_cycle2.29326555
23MP0003806_abnormal_nucleotide_metabolis2.27475761
24MP0003646_muscle_fatigue2.20344579
25MP0001879_abnormal_lymphatic_vessel2.10079748
26MP0008057_abnormal_DNA_replication2.02790757
27MP0003183_abnormal_peptide_metabolism2.00926111
28MP0008932_abnormal_embryonic_tissue1.73543090
29MP0003186_abnormal_redox_activity1.73250183
30MP0002161_abnormal_fertility/fecundity1.58824940
31MP0005623_abnormal_meninges_morphology1.57177070
32MP0004808_abnormal_hematopoietic_stem1.55959492
33MP0001119_abnormal_female_reproductive1.54466905
34MP0003121_genomic_imprinting1.51911415
35MP0001730_embryonic_growth_arrest1.50184903
36MP0003878_abnormal_ear_physiology1.44477528
37MP0005377_hearing/vestibular/ear_phenot1.44477528
38MP0000462_abnormal_digestive_system1.43399272
39MP0005409_darkened_coat_color1.42603699
40MP0001177_atelectasis1.39925545
41MP0005075_abnormal_melanosome_morpholog1.39550429
42MP0000678_abnormal_parathyroid_gland1.37622614
43MP0003890_abnormal_embryonic-extraembry1.36768858
44MP0005058_abnormal_lysosome_morphology1.36750823
45MP0002102_abnormal_ear_morphology1.36371416
46MP0010352_gastrointestinal_tract_polyps1.35584600
47MP0010307_abnormal_tumor_latency1.34961056
48MP0008007_abnormal_cellular_replicative1.31343637
49MP0005408_hypopigmentation1.28985467
50MP0000350_abnormal_cell_proliferation1.27752234
51MP0005410_abnormal_fertilization1.22173571
52MP0006035_abnormal_mitochondrial_morpho1.20431129
53MP0001293_anophthalmia1.20106755
54MP0002877_abnormal_melanocyte_morpholog1.17670870
55MP0005076_abnormal_cell_differentiation1.10236571
56MP0003787_abnormal_imprinting1.09101903
57MP0004215_abnormal_myocardial_fiber1.06643262
58MP0000358_abnormal_cell_content/1.06377160
59MP0003943_abnormal_hepatobiliary_system1.05552673
60MP0004197_abnormal_fetal_growth/weight/1.05412305
61MP0003699_abnormal_female_reproductive1.04311071
62MP0009379_abnormal_foot_pigmentation1.03569049
63MP0000015_abnormal_ear_pigmentation0.99264195
64MP0009250_abnormal_appendicular_skeleto0.98137271
65MP0002085_abnormal_embryonic_tissue0.97762269
66MP0003959_abnormal_lean_body0.96738873
67MP0002084_abnormal_developmental_patter0.96208645
68MP0002009_preneoplasia0.93012006
69MP0002095_abnormal_skin_pigmentation0.92379136
70MP0005670_abnormal_white_adipose0.92120660
71MP0001697_abnormal_embryo_size0.91017342
72MP0005330_cardiomyopathy0.90546023
73MP0010234_abnormal_vibrissa_follicle0.88756545
74MP0001661_extended_life_span0.87797175
75MP0002075_abnormal_coat/hair_pigmentati0.86924820
76MP0004233_abnormal_muscle_weight0.86910541
77MP0001672_abnormal_embryogenesis/_devel0.86183269
78MP0005380_embryogenesis_phenotype0.86183269
79MP0002160_abnormal_reproductive_system0.83988503
80MP0000427_abnormal_hair_cycle0.82375265
81MP0000371_diluted_coat_color0.82000030
82MP0003937_abnormal_limbs/digits/tail_de0.81156191
83MP0009672_abnormal_birth_weight0.80279755
84MP0001986_abnormal_taste_sensitivity0.79438795
85MP0003984_embryonic_growth_retardation0.78897948
86MP0002080_prenatal_lethality0.78611565
87MP0001764_abnormal_homeostasis0.78281243
88MP0003705_abnormal_hypodermis_morpholog0.77593837
89MP0002019_abnormal_tumor_incidence0.77518537
90MP0003880_abnormal_central_pattern0.73705891
91MP0002088_abnormal_embryonic_growth/wei0.71882359
92MP0004885_abnormal_endolymph0.71753956
93MP0000313_abnormal_cell_death0.70775722
94MP0002233_abnormal_nose_morphology0.70676353
95MP0002163_abnormal_gland_morphology0.68103118
96MP0009703_decreased_birth_body0.67903986
97MP0002735_abnormal_chemical_nociception0.67498124
98MP0003567_abnormal_fetal_cardiomyocyte0.67102583
99MP0002092_abnormal_eye_morphology0.66160019
100MP0005647_abnormal_sex_gland0.66086859
101MP0002089_abnormal_postnatal_growth/wei0.65907171
102MP0002086_abnormal_extraembryonic_tissu0.63838800
103MP0005360_urolithiasis0.61968005
104MP0000569_abnormal_digit_pigmentation0.61531698
105MP0001186_pigmentation_phenotype0.60783939
106MP0002796_impaired_skin_barrier0.59315357
107MP0003941_abnormal_skin_development0.58982732
108MP0005248_abnormal_Harderian_gland0.58607429
109MP0003566_abnormal_cell_adhesion0.57902062
110MP0000751_myopathy0.57751050
111MP0003936_abnormal_reproductive_system0.57731942
112MP0004782_abnormal_surfactant_physiolog0.57271944
113MP0003136_yellow_coat_color0.56288918
114MP0003315_abnormal_perineum_morphology0.54206944
115MP0003718_maternal_effect0.53743267
116MP0010678_abnormal_skin_adnexa0.53257838
117MP0002269_muscular_atrophy0.51918570
118MP0008004_abnormal_stomach_pH0.51701981
119MP0003119_abnormal_digestive_system0.51329864
120MP0000579_abnormal_nail_morphology0.49919248
121MP0005645_abnormal_hypothalamus_physiol0.49634365
122MP0002837_dystrophic_cardiac_calcinosis0.48839360
123MP0002184_abnormal_innervation0.48318712
124MP0006138_congestive_heart_failure0.47156501
125MP0002938_white_spotting0.46777858
126MP0001191_abnormal_skin_condition0.45603550
127MP0003861_abnormal_nervous_system0.45578650
128MP0003115_abnormal_respiratory_system0.45090186
129MP0002114_abnormal_axial_skeleton0.45008695
130MP0008789_abnormal_olfactory_epithelium0.44715512
131MP0001529_abnormal_vocalization0.43964826
132MP0005621_abnormal_cell_physiology0.43682570
133MP0000467_abnormal_esophagus_morphology0.43011576
134MP0002697_abnormal_eye_size0.42473085
135MP0006292_abnormal_olfactory_placode0.42245588
136MP0000377_abnormal_hair_follicle0.41563690
137MP0009697_abnormal_copulation0.41070976
138MP0000432_abnormal_head_morphology0.41067641
139MP0005389_reproductive_system_phenotype0.40892240
140MP0005257_abnormal_intraocular_pressure0.40036358
141MP0003935_abnormal_craniofacial_develop0.39413338
142MP0001915_intracranial_hemorrhage0.39229418
143MP0000534_abnormal_ureter_morphology0.38994421
144MP0003755_abnormal_palate_morphology0.38648682
145MP0010030_abnormal_orbit_morphology0.37634989
146MP0005384_cellular_phenotype0.37473298
147MP0000490_abnormal_crypts_of0.37425239
148MP0002249_abnormal_larynx_morphology0.37016750

Predicted human phenotypes

RankGene SetZ-score
1Abnormal spermatogenesis (HP:0008669)9.54242638
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.34306634
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.34306634
4Chromsome breakage (HP:0040012)4.96940797
5Osteomalacia (HP:0002749)4.94815757
6Abnormality of the corticospinal tract (HP:0002492)4.61186098
7Abnormality of the costochondral junction (HP:0000919)4.60009278
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.50978231
9Scotoma (HP:0000575)4.43606328
10Papillary thyroid carcinoma (HP:0002895)4.30690196
11Gonadotropin excess (HP:0000837)4.19990985
12Horizontal nystagmus (HP:0000666)4.17484741
13Delayed epiphyseal ossification (HP:0002663)4.08349026
14Hyperglycinuria (HP:0003108)3.86698738
15Facial hemangioma (HP:0000329)3.82927710
16Abnormality of the lower motor neuron (HP:0002366)3.61548163
17Tubulointerstitial nephritis (HP:0001970)3.37820437
18Cutaneous melanoma (HP:0012056)3.30154813
1911 pairs of ribs (HP:0000878)3.27381342
20Agnosia (HP:0010524)3.19722406
21Abnormality of DNA repair (HP:0003254)3.15316030
22Hyperglycinemia (HP:0002154)3.06521096
23Abnormality of the labia minora (HP:0012880)3.04382054
24Abnormality of chromosome stability (HP:0003220)3.03931979
25Capillary hemangiomas (HP:0005306)3.01619468
26Ankle contracture (HP:0006466)3.01524597
27Ectopic kidney (HP:0000086)2.98684763
28Impulsivity (HP:0100710)2.88998373
29Broad distal phalanx of finger (HP:0009836)2.87733369
30Abnormality of the aortic arch (HP:0012303)2.85308895
31Spontaneous abortion (HP:0005268)2.81903390
32Thin bony cortex (HP:0002753)2.77722902
33Thyroid carcinoma (HP:0002890)2.77508541
34Abnormality of the renal collecting system (HP:0004742)2.75290084
35Absent thumb (HP:0009777)2.73631432
36Microglossia (HP:0000171)2.70503343
37Abnormality of serine family amino acid metabolism (HP:0010894)2.68976402
38Abnormality of glycine metabolism (HP:0010895)2.68976402
39Rhabdomyosarcoma (HP:0002859)2.68049951
40Reticulocytopenia (HP:0001896)2.64642093
41Carpal bone hypoplasia (HP:0001498)2.58619700
42Heterotopia (HP:0002282)2.55767749
43Gonadal dysgenesis (HP:0000133)2.53341476
44Colon cancer (HP:0003003)2.50250793
45Meckel diverticulum (HP:0002245)2.50176388
46Rickets (HP:0002748)2.48244755
47Abnormality of the phalanges of the hallux (HP:0010057)2.46387362
48Oligodactyly (HP:0012165)2.46290156
49Abnormal lung lobation (HP:0002101)2.44194188
50Increased nuchal translucency (HP:0010880)2.42969641
51Enlarged epiphyses (HP:0010580)2.41741355
52Septate vagina (HP:0001153)2.41424359
53Impaired vibration sensation in the lower limbs (HP:0002166)2.41158267
54Supernumerary spleens (HP:0009799)2.38532614
55Hypopigmentation of the fundus (HP:0007894)2.34347174
56Ependymoma (HP:0002888)2.34044751
57Widely patent fontanelles and sutures (HP:0004492)2.32841349
58Urinary urgency (HP:0000012)2.31942493
59Upper motor neuron abnormality (HP:0002127)2.31486004
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.30799069
61Facial cleft (HP:0002006)2.29495837
62Shoulder girdle muscle weakness (HP:0003547)2.28863017
63Abnormality of the ileum (HP:0001549)2.28057966
64Fibular hypoplasia (HP:0003038)2.24457409
65Selective tooth agenesis (HP:0001592)2.22148503
66Atrophy/Degeneration involving motor neurons (HP:0007373)2.21701427
67Pelvic girdle muscle weakness (HP:0003749)2.21097681
68Abnormality of the carotid arteries (HP:0005344)2.20067317
69Short thumb (HP:0009778)2.19877314
70Renovascular hypertension (HP:0100817)2.19635628
71Abnormality of the preputium (HP:0100587)2.19611742
72Squamous cell carcinoma (HP:0002860)2.18961895
73Rectal fistula (HP:0100590)2.17523549
74Rectovaginal fistula (HP:0000143)2.17523549
75Absent radius (HP:0003974)2.17003430
76Vertebral arch anomaly (HP:0008438)2.16748209
77Basal cell carcinoma (HP:0002671)2.15160605
78Shawl scrotum (HP:0000049)2.14776906
79Hand muscle atrophy (HP:0009130)2.13610518
80Wide cranial sutures (HP:0010537)2.13522789
81Prominent supraorbital ridges (HP:0000336)2.13345030
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.12611651
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12508422
84Duplicated collecting system (HP:0000081)2.11716685
85Aplasia/Hypoplasia of the macula (HP:0008059)2.09262093
86Absent forearm bone (HP:0003953)2.08629547
87Aplasia involving forearm bones (HP:0009822)2.08629547
88Neoplasm of striated muscle (HP:0009728)2.07844110
89Small intestinal stenosis (HP:0012848)2.07699946
90Duodenal stenosis (HP:0100867)2.07699946
91Neoplasm of head and neck (HP:0012288)2.07433398
92Esophageal neoplasm (HP:0100751)2.07433398
93Metaphyseal irregularity (HP:0003025)2.07277768
94Hypokinesia (HP:0002375)2.06719750
95Cafe-au-lait spot (HP:0000957)2.05629005
96Medulloblastoma (HP:0002885)2.05212429
97Breast hypoplasia (HP:0003187)2.03899878
98Retinal dysplasia (HP:0007973)2.03505772
99Astrocytoma (HP:0009592)2.03007846
100Abnormality of the astrocytes (HP:0100707)2.03007846
101Freckling (HP:0001480)2.02371590
102Birth length less than 3rd percentile (HP:0003561)2.00698805
103Azoospermia (HP:0000027)11.4171356
104Microvesicular hepatic steatosis (HP:0001414)1.99947667
105Urethral obstruction (HP:0000796)1.97904140
106Leiomyosarcoma (HP:0100243)1.97848216
107Uterine leiomyosarcoma (HP:0002891)1.97848216
108Short 4th metacarpal (HP:0010044)1.97334526
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97334526
110Amyotrophic lateral sclerosis (HP:0007354)1.97173081
111Proximal placement of thumb (HP:0009623)1.96579070
112Sandal gap (HP:0001852)1.95944065
113Limb-girdle muscle weakness (HP:0003325)1.94711963
114Metaphyseal cupping (HP:0003021)1.94092105
115Tongue fasciculations (HP:0001308)1.94088817
116Abnormal protein glycosylation (HP:0012346)1.93976718
117Abnormal glycosylation (HP:0012345)1.93976718
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93976718
119Abnormal protein N-linked glycosylation (HP:0012347)1.93976718
120Anteriorly placed anus (HP:0001545)1.93947024
121Abnormal biliary tract morphology (HP:0012440)1.93832447
122Hypoplasia of the uterus (HP:0000013)1.92862655
123Rimmed vacuoles (HP:0003805)1.91960592
124Broad palm (HP:0001169)1.91942259
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90154802
126Volvulus (HP:0002580)1.88040499
127Male infertility (HP:0003251)1.86836378
128Flat occiput (HP:0005469)1.84735161
129Biliary tract neoplasm (HP:0100574)1.84398267
130Glioma (HP:0009733)1.83533803
131Neoplasm of the oral cavity (HP:0100649)1.83064540
132Duplication of thumb phalanx (HP:0009942)1.82733210
133Spinal muscular atrophy (HP:0007269)1.82071173
134Hypergonadotropic hypogonadism (HP:0000815)1.82027716
135Missing ribs (HP:0000921)1.81877316
136Urinary bladder sphincter dysfunction (HP:0002839)1.81689147
137Progressive external ophthalmoplegia (HP:0000590)1.81486661
138Overlapping toe (HP:0001845)1.81151064
139Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80817448
140Deviation of the thumb (HP:0009603)1.80685281
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80162233
142Neoplasm of the colon (HP:0100273)1.79725858
143Redundant skin (HP:0001582)1.79256911
144Abnormality of chromosome segregation (HP:0002916)1.78656925
145Short tibia (HP:0005736)1.78481830
146Abnormality of the hip-girdle musculature (HP:0001445)1.78338299
147Abnormality of the musculature of the pelvis (HP:0001469)1.78338299
148Muscle fibrillation (HP:0010546)1.77093561
149Neoplasm of the rectum (HP:0100743)1.76842826
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.75738478
151Horseshoe kidney (HP:0000085)1.74903174
152Abnormality of the duodenum (HP:0002246)1.74722735
153Beaking of vertebral bodies (HP:0004568)1.74003837
154Patellar aplasia (HP:0006443)1.73830406
155Spastic paraplegia (HP:0001258)1.73735050
156Truncal obesity (HP:0001956)1.73482800
157Poor coordination (HP:0002370)1.73435163
158Central scotoma (HP:0000603)1.72756566
159White forelock (HP:0002211)1.71220486
160Premature graying of hair (HP:0002216)1.69739191
161Male pseudohermaphroditism (HP:0000037)1.69698286
162Supernumerary ribs (HP:0005815)1.69605366
163Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69565629
164Cortical dysplasia (HP:0002539)1.69204395
165Asplenia (HP:0001746)1.68869081
166Hyperacusis (HP:0010780)1.68543042
167Type I transferrin isoform profile (HP:0003642)1.68318975
168Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66786014
169Wrist flexion contracture (HP:0001239)1.66148642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.68547972
2ACVR1B6.03457507
3CDK196.00148863
4CDK125.65802562
5CDC75.43432876
6STK38L3.61827581
7STK243.29474940
8CASK3.04121775
9STK392.96974101
10WNK42.93167480
11WEE12.64928076
12NEK22.39494552
13KSR22.14187528
14PLK42.04360916
15PLK11.95286243
16PBK1.95191531
17EPHA41.87798504
18NEK11.80393016
19TTK1.76769000
20BRD41.73199790
21MST1R1.73162233
22TAF11.72477712
23PDK31.68640727
24PDK41.68640727
25MATK1.67123860
26WNK11.57585058
27ATR1.57439835
28STK161.54697687
29NTRK31.52134497
30PASK1.52033125
31BRSK21.51823473
32CHEK11.51546375
33MKNK21.51185969
34STK31.46747574
35MARK31.45586926
36CHEK21.40986501
37CDK41.38176394
38MET1.34054887
39CDK71.32759348
40MELK1.24426479
41KIT1.21866454
42ATM1.21155437
43NEK91.21149301
44BRSK11.20573957
45MAP3K41.20088083
46BRAF1.18514336
47MKNK11.13332570
48CAMK1G1.10693295
49EIF2AK31.09018634
50AURKB1.04645212
51PLK31.02166838
52RAF11.01794608
53BUB10.99341276
54GRK70.99329811
55TYRO30.98198903
56CSNK1A1L0.96925633
57EEF2K0.95579349
58TRIM280.92994655
59PLK20.89876595
60IRAK30.85870700
61PKN20.84989090
62IRAK10.81197180
63CDK20.80977796
64MAPK110.80252659
65CAMK1D0.77934905
66CSNK1G30.77126095
67ICK0.76978681
68CDC42BPA0.76036971
69SCYL20.73996886
70CDK10.73573247
71STK40.73059709
72PDK20.72767377
73CSNK1G10.70859077
74MAP3K10.68120319
75MAP3K60.67660640
76NEK60.66310299
77CSNK1G20.64090345
78KSR10.63909478
79BCR0.63154609
80TSSK60.62659346
81ZAK0.62560515
82MTOR0.60957011
83RPS6KB10.59069965
84YES10.57451737
85RIPK10.54486445
86CLK10.54253370
87CDK80.52735752
88AURKA0.51668300
89RPS6KB20.51198419
90PRKDC0.50231743
91MAP3K20.49134190
92BMPR1B0.48404090
93RET0.48399053
94CDK90.48295272
95BMX0.47802387
96CSNK1D0.46430553
97CSNK2A20.46368780
98CCNB10.45684336
99SRPK10.45511889
100GSK3B0.44626103
101ALK0.44502495
102CSNK1E0.42712972
103VRK10.42640937
104PIM10.40402132
105PRKD30.38698438
106STK380.38087496
107CDK11A0.36775883
108LMTK20.36574654
109CSF1R0.36474299
110FLT30.35888126
111PTK2B0.34173580
112MAP3K80.33633590
113ERBB40.33419492
114DYRK30.32667686
115PRKD20.32131521
116CSNK2A10.31310926
117CDK60.31197744
118BCKDK0.31182504
119MAP3K30.30649069
120SGK10.30150203
121ABL20.29224314
122MAPK100.28178533
123TGFBR10.28014329
124MAPK80.27903978
125MAPK140.25405836
126EGFR0.24991041
127PDGFRB0.24982007
128MAP3K70.24834133
129PDGFRA0.24113040
130RPS6KA10.22947494
131IGF1R0.22619375
132MAP3K100.22423733
133WNK30.22196593
134CDK30.21794932
135MAPKAPK30.21748980
136PHKG20.21213691
137PHKG10.21213691
138PTK60.20987591
139MAP2K10.20669974
140PAK40.20172651
141CDK140.20081100
142PRKCI0.19896013
143LIMK10.19622098
144PRKCQ0.19556981
145AKT10.19297830
146OXSR10.18777891
147PTK20.17898924
148STK110.16897402

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.78291141
2Basal transcription factors_Homo sapiens_hsa030224.99052315
3Homologous recombination_Homo sapiens_hsa034404.21387359
4DNA replication_Homo sapiens_hsa030303.76595597
5Mismatch repair_Homo sapiens_hsa034303.47145427
6Cell cycle_Homo sapiens_hsa041103.35062523
7RNA transport_Homo sapiens_hsa030133.21130107
8Fanconi anemia pathway_Homo sapiens_hsa034603.13225194
9mRNA surveillance pathway_Homo sapiens_hsa030153.01660946
10RNA polymerase_Homo sapiens_hsa030202.68949055
11Nucleotide excision repair_Homo sapiens_hsa034202.65817544
12Folate biosynthesis_Homo sapiens_hsa007902.55885557
13Non-homologous end-joining_Homo sapiens_hsa034502.48779759
14Regulation of autophagy_Homo sapiens_hsa041402.45172202
15Spliceosome_Homo sapiens_hsa030402.40376328
16One carbon pool by folate_Homo sapiens_hsa006702.31660560
17Proteasome_Homo sapiens_hsa030502.29787559
18Selenocompound metabolism_Homo sapiens_hsa004502.24039235
19Ribosome_Homo sapiens_hsa030102.19113842
20Fatty acid elongation_Homo sapiens_hsa000622.11459223
21Oocyte meiosis_Homo sapiens_hsa041142.07120308
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84987742
23Base excision repair_Homo sapiens_hsa034101.82924323
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.77316497
25RNA degradation_Homo sapiens_hsa030181.76230972
26Pyrimidine metabolism_Homo sapiens_hsa002401.57530427
27p53 signaling pathway_Homo sapiens_hsa041151.49446056
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42843999
29Herpes simplex infection_Homo sapiens_hsa051681.34598074
30Dorso-ventral axis formation_Homo sapiens_hsa043201.29802069
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25384450
32Protein export_Homo sapiens_hsa030601.16223123
33Lysine degradation_Homo sapiens_hsa003101.16216353
34Epstein-Barr virus infection_Homo sapiens_hsa051691.14793086
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12900059
36Purine metabolism_Homo sapiens_hsa002301.11927681
37Thyroid cancer_Homo sapiens_hsa052161.11753251
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.08879876
39Fatty acid degradation_Homo sapiens_hsa000711.06600367
40Sulfur relay system_Homo sapiens_hsa041221.00173935
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99412662
42HTLV-I infection_Homo sapiens_hsa051660.92174107
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91974148
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88466974
45beta-Alanine metabolism_Homo sapiens_hsa004100.86900147
46ABC transporters_Homo sapiens_hsa020100.82071704
47Notch signaling pathway_Homo sapiens_hsa043300.81226287
48Huntingtons disease_Homo sapiens_hsa050160.77722553
49Viral carcinogenesis_Homo sapiens_hsa052030.76643670
50MicroRNAs in cancer_Homo sapiens_hsa052060.75220550
51Adherens junction_Homo sapiens_hsa045200.74590505
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73035000
53TGF-beta signaling pathway_Homo sapiens_hsa043500.67800225
54Small cell lung cancer_Homo sapiens_hsa052220.64439317
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64217676
56Tight junction_Homo sapiens_hsa045300.64192344
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62740743
58Pentose phosphate pathway_Homo sapiens_hsa000300.61924527
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58875475
60Influenza A_Homo sapiens_hsa051640.58592853
61Hippo signaling pathway_Homo sapiens_hsa043900.56966268
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.54770059
63Shigellosis_Homo sapiens_hsa051310.52071166
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49958553
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49174440
66Circadian rhythm_Homo sapiens_hsa047100.49039213
67Carbon metabolism_Homo sapiens_hsa012000.43904966
68Basal cell carcinoma_Homo sapiens_hsa052170.43799337
69Tyrosine metabolism_Homo sapiens_hsa003500.43268354
70Pathways in cancer_Homo sapiens_hsa052000.42779640
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.40223666
72Steroid biosynthesis_Homo sapiens_hsa001000.37945406
73Pancreatic cancer_Homo sapiens_hsa052120.36477843
74Fatty acid biosynthesis_Homo sapiens_hsa000610.34987330
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.34779137
76FoxO signaling pathway_Homo sapiens_hsa040680.34177688
77Lysosome_Homo sapiens_hsa041420.31950007
78Colorectal cancer_Homo sapiens_hsa052100.31320463
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30759541
80Systemic lupus erythematosus_Homo sapiens_hsa053220.30438980
81ECM-receptor interaction_Homo sapiens_hsa045120.29779176
82Wnt signaling pathway_Homo sapiens_hsa043100.28618420
83Legionellosis_Homo sapiens_hsa051340.27550837
84Glutathione metabolism_Homo sapiens_hsa004800.26256270
85Prion diseases_Homo sapiens_hsa050200.25822307
86Biosynthesis of amino acids_Homo sapiens_hsa012300.25312146
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25245880
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.24964469
89Renal cell carcinoma_Homo sapiens_hsa052110.23779220
90Hedgehog signaling pathway_Homo sapiens_hsa043400.23604932
91Prostate cancer_Homo sapiens_hsa052150.22302097
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.21902793
93Melanogenesis_Homo sapiens_hsa049160.21590822
94Retinol metabolism_Homo sapiens_hsa008300.20951636
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20454189
96Melanoma_Homo sapiens_hsa052180.20380131
97Alcoholism_Homo sapiens_hsa050340.19114791
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18261089
99Glycerolipid metabolism_Homo sapiens_hsa005610.16140298
100Focal adhesion_Homo sapiens_hsa045100.15791833
101Type II diabetes mellitus_Homo sapiens_hsa049300.15198118
102N-Glycan biosynthesis_Homo sapiens_hsa005100.14827829
103Proteoglycans in cancer_Homo sapiens_hsa052050.13301051
104Inositol phosphate metabolism_Homo sapiens_hsa005620.12373434
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12038606
106Axon guidance_Homo sapiens_hsa043600.09809160
107mTOR signaling pathway_Homo sapiens_hsa041500.09056318
108Fatty acid metabolism_Homo sapiens_hsa012120.08529851
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08442238
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.08390013
111ErbB signaling pathway_Homo sapiens_hsa040120.07839226
112Glucagon signaling pathway_Homo sapiens_hsa049220.07575692
113Parkinsons disease_Homo sapiens_hsa050120.07193763
114Vitamin B6 metabolism_Homo sapiens_hsa007500.06455966
115Non-small cell lung cancer_Homo sapiens_hsa052230.05975854
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.05783450
117Propanoate metabolism_Homo sapiens_hsa006400.05753491
118Gap junction_Homo sapiens_hsa045400.05663151
119Acute myeloid leukemia_Homo sapiens_hsa052210.04876471
120Choline metabolism in cancer_Homo sapiens_hsa052310.04759090
121Glioma_Homo sapiens_hsa052140.04572154
122AMPK signaling pathway_Homo sapiens_hsa041520.04120412
123Chronic myeloid leukemia_Homo sapiens_hsa052200.03518356
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03436582
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03410952
126Collecting duct acid secretion_Homo sapiens_hsa049660.02883388
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02778229
128Synaptic vesicle cycle_Homo sapiens_hsa047210.02503347
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02357325
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.02157054
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00765434
132Metabolic pathways_Homo sapiens_hsa01100-0.0264957
133Endocytosis_Homo sapiens_hsa04144-0.0182073
134HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0113098
135Glycine, serine and threonine metabolism_Homo sapiens_hsa00260-0.0112023
136Pyruvate metabolism_Homo sapiens_hsa00620-0.0047191

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