LURAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.02499784
2locomotory exploration behavior (GO:0035641)5.95988101
3neuronal action potential propagation (GO:0019227)5.56500134
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39160711
5synaptic vesicle maturation (GO:0016188)5.23352061
6respiratory chain complex IV assembly (GO:0008535)5.21261635
7cerebellar granule cell differentiation (GO:0021707)5.08699714
8behavioral response to nicotine (GO:0035095)5.02713762
9cellular potassium ion homeostasis (GO:0030007)5.00295998
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97886940
11vocalization behavior (GO:0071625)4.78368990
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.77836507
13NADH dehydrogenase complex assembly (GO:0010257)4.77836507
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.77836507
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.73620599
16protein complex biogenesis (GO:0070271)4.66983789
17synaptic vesicle exocytosis (GO:0016079)4.64024537
18cerebellar Purkinje cell differentiation (GO:0021702)4.58334552
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.56821946
20cytochrome complex assembly (GO:0017004)4.56246716
21sodium ion export (GO:0071436)4.51800588
22regulation of synaptic vesicle exocytosis (GO:2000300)4.51222959
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51010029
24glutamate receptor signaling pathway (GO:0007215)4.50279628
25mitochondrial respiratory chain complex assembly (GO:0033108)4.46038057
26glutamate secretion (GO:0014047)4.44239782
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41358471
28gamma-aminobutyric acid transport (GO:0015812)4.37334063
29synaptic transmission, glutamatergic (GO:0035249)4.36839726
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.31460754
31neurotransmitter secretion (GO:0007269)4.31446609
32response to pheromone (GO:0019236)4.20243786
33regulation of glutamate receptor signaling pathway (GO:1900449)4.17140036
34fucose catabolic process (GO:0019317)4.14415058
35L-fucose metabolic process (GO:0042354)4.14415058
36L-fucose catabolic process (GO:0042355)4.14415058
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.11739456
38neuron-neuron synaptic transmission (GO:0007270)4.07276512
39exploration behavior (GO:0035640)3.99219912
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.96273874
41regulation of synaptic vesicle transport (GO:1902803)3.91682002
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.91014659
43transmission of nerve impulse (GO:0019226)3.89299286
44cell differentiation in hindbrain (GO:0021533)3.85389392
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.82303460
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81571741
47neurotransmitter-gated ion channel clustering (GO:0072578)3.79827106
48long-term memory (GO:0007616)3.78660544
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77548011
50regulation of voltage-gated calcium channel activity (GO:1901385)3.75825060
51postsynaptic membrane organization (GO:0001941)3.68333192
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65732940
53protein localization to synapse (GO:0035418)3.65327079
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.64521784
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.63513518
56termination of RNA polymerase III transcription (GO:0006386)3.63513518
57cell communication by electrical coupling (GO:0010644)3.60753122
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57959122
59positive regulation of synapse maturation (GO:0090129)3.56884624
60detection of light stimulus involved in visual perception (GO:0050908)3.53248632
61detection of light stimulus involved in sensory perception (GO:0050962)3.53248632
62membrane depolarization during action potential (GO:0086010)3.50574203
63mannosylation (GO:0097502)3.50564357
64neurotransmitter transport (GO:0006836)3.48725844
65regulation of neuronal synaptic plasticity (GO:0048168)3.48410646
66potassium ion import (GO:0010107)3.48191750
67neuromuscular process controlling posture (GO:0050884)3.47380520
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44958065
69indole-containing compound catabolic process (GO:0042436)3.44117003
70indolalkylamine catabolic process (GO:0046218)3.44117003
71tryptophan catabolic process (GO:0006569)3.44117003
72neuron cell-cell adhesion (GO:0007158)3.39818486
73water-soluble vitamin biosynthetic process (GO:0042364)3.37581095
74axoneme assembly (GO:0035082)3.34227000
75neuromuscular process controlling balance (GO:0050885)3.33342860
76regulation of synapse structural plasticity (GO:0051823)3.32562933
77kynurenine metabolic process (GO:0070189)3.32232113
78potassium ion homeostasis (GO:0055075)3.32199501
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30383333
80positive regulation of membrane potential (GO:0045838)3.29501740
81membrane hyperpolarization (GO:0060081)3.28956579
82L-amino acid import (GO:0043092)3.28426066
83layer formation in cerebral cortex (GO:0021819)3.25927174
84piRNA metabolic process (GO:0034587)3.24735314
85regulation of postsynaptic membrane potential (GO:0060078)3.24524715
86synaptic vesicle endocytosis (GO:0048488)3.23896830
87regulation of neurotransmitter levels (GO:0001505)3.22494590
88protein polyglutamylation (GO:0018095)3.21747570
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20958667
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.20360757
91regulation of neurotransmitter secretion (GO:0046928)3.18650090
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.16109307
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14199096
94indolalkylamine metabolic process (GO:0006586)3.13566002
95negative regulation of telomere maintenance (GO:0032205)3.11987268
96neuromuscular synaptic transmission (GO:0007274)3.10117181
97membrane depolarization (GO:0051899)3.07242727
98proline transport (GO:0015824)3.07124929
99auditory receptor cell stereocilium organization (GO:0060088)3.06172625
100long-term synaptic potentiation (GO:0060291)3.05012159
101centriole replication (GO:0007099)3.04500646
102platelet dense granule organization (GO:0060155)3.03575307
103positive regulation of potassium ion transmembrane transport (GO:1901381)3.03112923
104glycine transport (GO:0015816)3.02625930
105cellular sodium ion homeostasis (GO:0006883)3.02491705
106adult walking behavior (GO:0007628)3.00920039
107regulation of neurotransmitter transport (GO:0051588)3.00542886
108regulation of cell communication by electrical coupling (GO:0010649)3.00274120
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99214715
110regulation of nuclear cell cycle DNA replication (GO:0033262)2.98953430
111synapse assembly (GO:0007416)2.98832526
112regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98556904
113regulation of synapse maturation (GO:0090128)2.97672127
114preassembly of GPI anchor in ER membrane (GO:0016254)2.96926341
115negative regulation of reactive oxygen species metabolic process (GO:2000378)2.96546282
116auditory behavior (GO:0031223)2.95272100
117regulation of action potential (GO:0098900)2.94677557
118regulation of cilium movement (GO:0003352)2.94632540
119activation of protein kinase A activity (GO:0034199)2.92513008
120regulation of synaptic plasticity (GO:0048167)2.91377550
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91144358
122response to auditory stimulus (GO:0010996)2.90787330
123cardiovascular system development (GO:0072358)2.89360050
124tryptophan metabolic process (GO:0006568)2.88445475
125dendrite morphogenesis (GO:0048813)2.86809204
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.86583506
127mechanosensory behavior (GO:0007638)2.86178322
128neuromuscular process (GO:0050905)2.85818635
129behavioral response to ethanol (GO:0048149)2.85721979
130negative regulation of hormone metabolic process (GO:0032351)2.85073743
131negative regulation of hormone biosynthetic process (GO:0032353)2.85073743
132synaptic transmission (GO:0007268)2.83743156
133C4-dicarboxylate transport (GO:0015740)2.83200636
134prepulse inhibition (GO:0060134)2.83128087
135regulation of beta-amyloid formation (GO:1902003)2.82501989
136retinal cone cell development (GO:0046549)2.82445551
137long term synaptic depression (GO:0060292)2.82261863
138inner ear receptor stereocilium organization (GO:0060122)2.80484541
139epithelial cilium movement (GO:0003351)2.79390264
140regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79017127
141neuronal action potential (GO:0019228)2.78821284
142membrane repolarization (GO:0086009)2.78798250
143seminiferous tubule development (GO:0072520)2.76980840
144relaxation of cardiac muscle (GO:0055119)2.75050989
145neuronal ion channel clustering (GO:0045161)2.74263373
146dendritic spine morphogenesis (GO:0060997)2.73298018
147intracellular protein transmembrane import (GO:0044743)2.72827142
148dopamine transport (GO:0015872)2.70388575
149male meiosis I (GO:0007141)2.69488818
150cellular biogenic amine catabolic process (GO:0042402)2.68319003
151amine catabolic process (GO:0009310)2.68319003
152regulation of glucokinase activity (GO:0033131)2.68231767
153regulation of hexokinase activity (GO:1903299)2.68231767
154cytidine deamination (GO:0009972)2.67479177
155cytidine metabolic process (GO:0046087)2.67479177
156cytidine catabolic process (GO:0006216)2.67479177
157epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67432526
158somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61320987
159somatic hypermutation of immunoglobulin genes (GO:0016446)2.61320987
160peptidyl-histidine modification (GO:0018202)2.59419196
161nonmotile primary cilium assembly (GO:0035058)2.59112843
162positive regulation of prostaglandin secretion (GO:0032308)2.57208748
163cellular ketone body metabolic process (GO:0046950)2.56518328
164photoreceptor cell development (GO:0042461)2.55791836
165ketone body metabolic process (GO:1902224)2.54786545
166glycosphingolipid biosynthetic process (GO:0006688)2.54143366
167cilium movement (GO:0003341)2.52359274
168regulation of posttranscriptional gene silencing (GO:0060147)2.52024973
169regulation of gene silencing by miRNA (GO:0060964)2.52024973
170regulation of gene silencing by RNA (GO:0060966)2.52024973
171sulfation (GO:0051923)2.51800945
172regulation of telomere maintenance (GO:0032204)2.51349749
173mitochondrial RNA metabolic process (GO:0000959)2.50215870
174chaperone-mediated protein transport (GO:0072321)2.49290415
175positive regulation of gastrulation (GO:2000543)2.48556273
176indole-containing compound metabolic process (GO:0042430)2.48374941
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47922768
178synapsis (GO:0007129)2.46344762
179regulation of neurotransmitter uptake (GO:0051580)2.44558226
180detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42285984
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41986841
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41986841
183DNA double-strand break processing (GO:0000729)2.41784410
184pyrimidine nucleobase catabolic process (GO:0006208)2.41130043
185rhodopsin mediated signaling pathway (GO:0016056)2.40736624
186DNA methylation involved in gamete generation (GO:0043046)2.40156897
187regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.39760854
188regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.39760854
189nucleobase catabolic process (GO:0046113)2.39436997
190pyrimidine ribonucleoside catabolic process (GO:0046133)2.38419695
191cilium or flagellum-dependent cell motility (GO:0001539)2.36144847
192photoreceptor cell maintenance (GO:0045494)2.36096691
193ubiquinone biosynthetic process (GO:0006744)2.35061834
194reciprocal DNA recombination (GO:0035825)2.35033302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.30807067
2VDR_22108803_ChIP-Seq_LS180_Human3.58142879
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.55122174
4GBX2_23144817_ChIP-Seq_PC3_Human3.43724712
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05925854
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89318392
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83386826
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67732095
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67732095
10DROSHA_22980978_ChIP-Seq_HELA_Human2.59403625
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46930409
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45090748
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45019565
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43844199
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39171881
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38060371
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37918592
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.33285504
19REST_21632747_ChIP-Seq_MESCs_Mouse2.31614426
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31026779
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.25874751
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.24507358
23FUS_26573619_Chip-Seq_HEK293_Human2.22385997
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.18326470
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11825169
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.10029100
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.07326393
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05309126
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05269187
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01825391
31EWS_26573619_Chip-Seq_HEK293_Human1.97817645
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95897136
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.89454051
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87728449
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.87184884
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.79966625
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.76987601
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76791043
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76537807
40AR_21572438_ChIP-Seq_LNCaP_Human1.73895346
41SMAD4_21799915_ChIP-Seq_A2780_Human1.67821125
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65944098
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65477558
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.60408390
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.59932418
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54940540
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54835739
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53301969
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51445244
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49613532
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49544896
52TP53_22573176_ChIP-Seq_HFKS_Human1.49054544
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.47799831
54MYC_18940864_ChIP-ChIP_HL60_Human1.47743571
55CBP_20019798_ChIP-Seq_JUKART_Human1.45890104
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45890104
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43516599
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41150432
59P300_19829295_ChIP-Seq_ESCs_Human1.40278805
60NANOG_19829295_ChIP-Seq_ESCs_Human1.35537633
61SOX2_19829295_ChIP-Seq_ESCs_Human1.35537633
62AR_25329375_ChIP-Seq_VCAP_Human1.35480872
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35398020
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.34853029
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33706692
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31455498
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29022517
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.28697164
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27850381
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27586528
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27261927
72STAT3_23295773_ChIP-Seq_U87_Human1.26422472
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26316033
74TCF4_22108803_ChIP-Seq_LS180_Human1.25875538
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.25019499
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24761074
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.24366824
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.23987016
79AR_19668381_ChIP-Seq_PC3_Human1.23754375
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23577537
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23302040
82ZNF274_21170338_ChIP-Seq_K562_Hela1.22883039
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22693380
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.22693380
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22473431
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20918545
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20704763
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19788988
89TAF15_26573619_Chip-Seq_HEK293_Human1.19642364
90IRF1_19129219_ChIP-ChIP_H3396_Human1.18464429
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.17427564
92TCF4_23295773_ChIP-Seq_U87_Human1.17369088
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.16841220
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16224579
95AR_20517297_ChIP-Seq_VCAP_Human1.14790136
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14700479
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.14289556
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14220604
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.14068733
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13587184
101AHR_22903824_ChIP-Seq_MCF-7_Human1.12590170
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12369648
103NCOR_22424771_ChIP-Seq_293T_Human1.11969149
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11418849
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11190638
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09765630
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09585424
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09561186
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09160902
110CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09096832
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09045934
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08973130
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.08531078
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07862454
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07661491
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06825546
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.06605122
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06239574
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06206358
120RNF2_27304074_Chip-Seq_NSC_Mouse1.05679196
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.05565067
122MYC_19829295_ChIP-Seq_ESCs_Human1.04896608
123RXR_22108803_ChIP-Seq_LS180_Human1.04354711
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04072969
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.03051849
126P53_22387025_ChIP-Seq_ESCs_Mouse1.02741507
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.02628011
128GATA3_21878914_ChIP-Seq_MCF-7_Human1.02242885
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02100810
130RUNX2_22187159_ChIP-Seq_PCA_Human1.01941580
131IGF1R_20145208_ChIP-Seq_DFB_Human1.01725912
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01391461
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00269465
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99587770
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98669837
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98603779
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97594391
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.97559692
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.96710750
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.96196790
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.95984638
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.95789569
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95747389
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95484992
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95484992
146TP53_16413492_ChIP-PET_HCT116_Human0.95440116
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95394844
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.95022711
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94867407
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92777728
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92740647
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88352808
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.88077201
154BCAT_22108803_ChIP-Seq_LS180_Human0.87926258
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87528239
156ER_23166858_ChIP-Seq_MCF-7_Human0.87491339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.16474939
2MP0009046_muscle_twitch4.33632212
3MP0003635_abnormal_synaptic_transmissio3.72837881
4MP0008877_abnormal_DNA_methylation3.28652768
5MP0009745_abnormal_behavioral_response3.21089830
6MP0004270_analgesia3.06575934
7MP0002064_seizures2.97259045
8MP0002102_abnormal_ear_morphology2.95759169
9MP0001968_abnormal_touch/_nociception2.95727943
10MP0003880_abnormal_central_pattern2.88933981
11MP0008569_lethality_at_weaning2.85565906
12MP0002272_abnormal_nervous_system2.82102518
13MP0002063_abnormal_learning/memory/cond2.78719779
14MP0002734_abnormal_mechanical_nocicepti2.69271291
15MP0001486_abnormal_startle_reflex2.61890684
16MP0002572_abnormal_emotion/affect_behav2.56682039
17MP0002067_abnormal_sensory_capabilities2.37592210
18MP0005423_abnormal_somatic_nervous2.31710155
19MP0001984_abnormal_olfaction2.30323118
20MP0002736_abnormal_nociception_after2.23971999
21MP0002735_abnormal_chemical_nociception2.17250706
22MP0002876_abnormal_thyroid_physiology2.05270537
23MP0003195_calcinosis2.03380000
24MP0006072_abnormal_retinal_apoptosis2.00965107
25MP0000372_irregular_coat_pigmentation1.99845821
26MP0001440_abnormal_grooming_behavior1.95307050
27MP0002184_abnormal_innervation1.93063794
28MP0002837_dystrophic_cardiac_calcinosis1.91049611
29MP0003252_abnormal_bile_duct1.88246029
30MP0002557_abnormal_social/conspecific_i1.88067044
31MP0001501_abnormal_sleep_pattern1.84287186
32MP0004145_abnormal_muscle_electrophysio1.81239660
33MP0004147_increased_porphyrin_level1.76535607
34MP0005499_abnormal_olfactory_system1.72668156
35MP0005394_taste/olfaction_phenotype1.72668156
36MP0004885_abnormal_endolymph1.72069198
37MP0001502_abnormal_circadian_rhythm1.71258378
38MP0004142_abnormal_muscle_tone1.70643910
39MP0004133_heterotaxia1.68985477
40MP0003879_abnormal_hair_cell1.67513070
41MP0001970_abnormal_pain_threshold1.67330433
42MP0005645_abnormal_hypothalamus_physiol1.66223075
43MP0002733_abnormal_thermal_nociception1.65880893
44MP0005646_abnormal_pituitary_gland1.62813789
45MP0009780_abnormal_chondrocyte_physiolo1.61455911
46MP0001529_abnormal_vocalization1.61147964
47MP0002909_abnormal_adrenal_gland1.60483695
48MP0004924_abnormal_behavior1.59702762
49MP0005386_behavior/neurological_phenoty1.59702762
50MP0004742_abnormal_vestibular_system1.55503221
51MP0004858_abnormal_nervous_system1.50431515
52MP0000778_abnormal_nervous_system1.49460428
53MP0003787_abnormal_imprinting1.47496624
54MP0000015_abnormal_ear_pigmentation1.45386536
55MP0002938_white_spotting1.41681292
56MP0010386_abnormal_urinary_bladder1.39462185
57MP0002882_abnormal_neuron_morphology1.34818874
58MP0000955_abnormal_spinal_cord1.34619508
59MP0004043_abnormal_pH_regulation1.34483059
60MP0002066_abnormal_motor_capabilities/c1.34469855
61MP0003121_genomic_imprinting1.33807008
62MP0005174_abnormal_tail_pigmentation1.32523659
63MP0003633_abnormal_nervous_system1.32391992
64MP0006292_abnormal_olfactory_placode1.30337092
65MP0002095_abnormal_skin_pigmentation1.28532853
66MP0004811_abnormal_neuron_physiology1.26176112
67MP0001188_hyperpigmentation1.25617531
68MP0006035_abnormal_mitochondrial_morpho1.24044139
69MP0001485_abnormal_pinna_reflex1.22846598
70MP0003631_nervous_system_phenotype1.22147748
71MP0004484_altered_response_of1.21514476
72MP0003123_paternal_imprinting1.20910337
73MP0000569_abnormal_digit_pigmentation1.17912650
74MP0003632_abnormal_nervous_system1.16025314
75MP0008995_early_reproductive_senescence1.15722842
76MP0003283_abnormal_digestive_organ1.15409487
77MP0001905_abnormal_dopamine_level1.15263917
78MP0008872_abnormal_physiological_respon1.14549297
79MP0002163_abnormal_gland_morphology1.14227193
80MP0005389_reproductive_system_phenotype1.12826979
81MP0005551_abnormal_eye_electrophysiolog1.12154680
82MP0003646_muscle_fatigue1.12080869
83MP0005085_abnormal_gallbladder_physiolo1.11217640
84MP0001963_abnormal_hearing_physiology1.10440552
85MP0003690_abnormal_glial_cell1.08024501
86MP0005409_darkened_coat_color1.07814719
87MP0008875_abnormal_xenobiotic_pharmacok1.04347333
88MP0008775_abnormal_heart_ventricle1.03380969
89MP0003329_amyloid_beta_deposits1.02502067
90MP0006276_abnormal_autonomic_nervous1.02154926
91MP0001986_abnormal_taste_sensitivity1.01044671
92MP0002638_abnormal_pupillary_reflex1.00758310
93MP0002152_abnormal_brain_morphology1.00515294
94MP0002229_neurodegeneration0.97853997
95MP0000427_abnormal_hair_cycle0.97588422
96MP0008058_abnormal_DNA_repair0.94205658
97MP0000383_abnormal_hair_follicle0.94052534
98MP0005075_abnormal_melanosome_morpholog0.91801841
99MP0002928_abnormal_bile_duct0.91675762
100MP0004215_abnormal_myocardial_fiber0.91080567
101MP0003698_abnormal_male_reproductive0.90797093
102MP0002089_abnormal_postnatal_growth/wei0.87741297
103MP0005503_abnormal_tendon_morphology0.87638926
104MP0003137_abnormal_impulse_conducting0.87548330
105MP0005379_endocrine/exocrine_gland_phen0.86999575
106MP0005084_abnormal_gallbladder_morpholo0.86873017
107MP0003011_delayed_dark_adaptation0.86855278
108MP0003045_fibrosis0.86723939
109MP0001919_abnormal_reproductive_system0.86377414
110MP0000631_abnormal_neuroendocrine_gland0.86337746
111MP0003786_premature_aging0.85626291
112MP0002751_abnormal_autonomic_nervous0.85059375
113MP0008789_abnormal_olfactory_epithelium0.83800888
114MP0002752_abnormal_somatic_nervous0.83794785
115MP0000516_abnormal_urinary_system0.83376319
116MP0005367_renal/urinary_system_phenotyp0.83376319
117MP0003806_abnormal_nucleotide_metabolis0.82476053
118MP0002138_abnormal_hepatobiliary_system0.82436758
119MP0000751_myopathy0.80916590
120MP0002822_catalepsy0.80303781
121MP0001177_atelectasis0.79769852
122MP0000920_abnormal_myelination0.79692759
123MP0004085_abnormal_heartbeat0.78980455
124MP0004233_abnormal_muscle_weight0.76233868
125MP0003136_yellow_coat_color0.75467794
126MP0002069_abnormal_eating/drinking_beha0.74340857
127MP0003878_abnormal_ear_physiology0.74248924
128MP0005377_hearing/vestibular/ear_phenot0.74248924
129MP0008874_decreased_physiological_sensi0.71309340
130MP0000026_abnormal_inner_ear0.70348372
131MP0000013_abnormal_adipose_tissue0.69737827
132MP0003634_abnormal_glial_cell0.67570949
133MP0004510_myositis0.65910053
134MP0001664_abnormal_digestion0.65849736
135MP0002160_abnormal_reproductive_system0.65617189
136MP0001270_distended_abdomen0.65403942
137MP0005623_abnormal_meninges_morphology0.64682635
138MP0005535_abnormal_body_temperature0.64437477
139MP0005171_absent_coat_pigmentation0.63228455
140MP0002653_abnormal_ependyma_morphology0.63172011
141MP0005410_abnormal_fertilization0.62703370
142MP0005253_abnormal_eye_physiology0.60495959
143MP0001299_abnormal_eye_distance/0.59097091

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.91718268
2Action tremor (HP:0002345)6.31597381
3Progressive cerebellar ataxia (HP:0002073)5.85758584
4Febrile seizures (HP:0002373)5.81528999
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.31073692
6Abnormality of alanine metabolism (HP:0010916)5.31073692
7Hyperalaninemia (HP:0003348)5.31073692
8Focal seizures (HP:0007359)5.11408149
9Visual hallucinations (HP:0002367)5.02247871
10Myokymia (HP:0002411)4.94298777
11Gaze-evoked nystagmus (HP:0000640)4.81392381
12Atonic seizures (HP:0010819)4.64490917
13Scanning speech (HP:0002168)4.50091115
14Epileptic encephalopathy (HP:0200134)4.50006011
15Absence seizures (HP:0002121)3.90031355
16Pancreatic cysts (HP:0001737)3.87634412
17Congenital stationary night blindness (HP:0007642)3.86689288
18Abnormality of midbrain morphology (HP:0002418)3.81684551
19Molar tooth sign on MRI (HP:0002419)3.81684551
20Broad-based gait (HP:0002136)3.70499833
21Dysdiadochokinesis (HP:0002075)3.59207011
22Genetic anticipation (HP:0003743)3.52300460
23Hepatocellular necrosis (HP:0001404)3.44950688
24Dialeptic seizures (HP:0011146)3.37451570
25True hermaphroditism (HP:0010459)3.36070039
26Impaired smooth pursuit (HP:0007772)3.32547025
27Generalized tonic-clonic seizures (HP:0002069)3.30628276
28Dysmetric saccades (HP:0000641)3.29583102
29Truncal ataxia (HP:0002078)3.24476611
30Abnormality of ocular smooth pursuit (HP:0000617)3.22173159
31Hemiplegia (HP:0002301)3.20714560
32Nephronophthisis (HP:0000090)3.19981547
33Hepatic necrosis (HP:0002605)3.19414716
34Mitochondrial inheritance (HP:0001427)3.18814447
35Abnormality of binocular vision (HP:0011514)3.14694340
36Diplopia (HP:0000651)3.14694340
37Increased CSF lactate (HP:0002490)3.14520250
38Acute necrotizing encephalopathy (HP:0006965)3.05266727
39Hemiparesis (HP:0001269)2.90982545
40Dysmetria (HP:0001310)2.89939634
41Poor eye contact (HP:0000817)2.89565557
42Abnormality of the renal medulla (HP:0100957)2.88656166
43Intention tremor (HP:0002080)2.88180097
44Pendular nystagmus (HP:0012043)2.82548421
45Progressive macrocephaly (HP:0004481)2.80201593
46Abnormality of the renal cortex (HP:0011035)2.76599496
47Type II lissencephaly (HP:0007260)2.74855650
48Abnormal rod and cone electroretinograms (HP:0008323)2.73913585
49Medial flaring of the eyebrow (HP:0010747)2.71931983
50Abnormal mitochondria in muscle tissue (HP:0008316)2.64444714
51Spinal canal stenosis (HP:0003416)2.54377214
52Attenuation of retinal blood vessels (HP:0007843)2.54253424
53Acute encephalopathy (HP:0006846)2.52185175
54Abnormal social behavior (HP:0012433)2.51633118
55Impaired social interactions (HP:0000735)2.51633118
56Depression (HP:0000716)2.50586941
57Limb ataxia (HP:0002070)2.48018591
58Abolished electroretinogram (ERG) (HP:0000550)2.46512484
59Cystic liver disease (HP:0006706)2.45180142
60Increased serum lactate (HP:0002151)2.44969516
61Fair hair (HP:0002286)2.42707353
62Anxiety (HP:0000739)2.42027873
633-Methylglutaconic aciduria (HP:0003535)2.39544970
64Ankle clonus (HP:0011448)2.38550564
65Progressive inability to walk (HP:0002505)2.36403864
66Annular pancreas (HP:0001734)2.35677517
67Postural tremor (HP:0002174)2.35400264
68Stereotypic behavior (HP:0000733)2.34590520
69Chronic hepatic failure (HP:0100626)2.34353932
70Nonprogressive disorder (HP:0003680)2.34063188
71Abnormal eating behavior (HP:0100738)2.33780566
72Fetal akinesia sequence (HP:0001989)2.33098715
73Ventricular fibrillation (HP:0001663)2.32927021
74Progressive microcephaly (HP:0000253)2.28991481
75Increased corneal curvature (HP:0100692)2.27715574
76Keratoconus (HP:0000563)2.27715574
77Abnormality of saccadic eye movements (HP:0000570)2.27226157
78Gait imbalance (HP:0002141)2.26591122
79Status epilepticus (HP:0002133)2.26589358
80Impaired vibration sensation in the lower limbs (HP:0002166)2.24588293
81Large for gestational age (HP:0001520)2.22961044
82Pheochromocytoma (HP:0002666)2.22367123
83Postural instability (HP:0002172)2.20875034
84Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20460442
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20177347
86Narrow nasal bridge (HP:0000446)2.19962829
87Renal cortical cysts (HP:0000803)2.17640938
88Hypoplasia of the fovea (HP:0007750)2.14765983
89Aplasia/Hypoplasia of the fovea (HP:0008060)2.14765983
90Increased hepatocellular lipid droplets (HP:0006565)2.13159289
91Hypoproteinemia (HP:0003075)2.12831476
92Congenital primary aphakia (HP:0007707)2.11471476
93Horizontal nystagmus (HP:0000666)2.10958551
94Aplasia involving bones of the upper limbs (HP:0009823)2.09881685
95Aplasia of the phalanges of the hand (HP:0009802)2.09881685
96Aplasia involving bones of the extremities (HP:0009825)2.09881685
97Gait ataxia (HP:0002066)2.08075381
98Lissencephaly (HP:0001339)2.07996299
99Leukodystrophy (HP:0002415)2.07845181
100Abnormality of the labia minora (HP:0012880)2.06521683
101Abnormal hair whorl (HP:0010721)2.05356877
102Nephrogenic diabetes insipidus (HP:0009806)2.05308870
103Pointed chin (HP:0000307)2.04512889
104Sclerocornea (HP:0000647)2.04146634
105Lipid accumulation in hepatocytes (HP:0006561)2.04121464
106Generalized hypopigmentation of hair (HP:0011358)2.04110050
107Polyuria (HP:0000103)2.04026336
108Supranuclear gaze palsy (HP:0000605)2.03964222
109Optic disc pallor (HP:0000543)2.00441897
110Hyperventilation (HP:0002883)1.98888717
111Decreased central vision (HP:0007663)1.98545516
112Neuroendocrine neoplasm (HP:0100634)1.98508397
113Retinal dysplasia (HP:0007973)1.97100941
114Lactic acidosis (HP:0003128)1.96080763
115Polydipsia (HP:0001959)1.95983694
116Abnormal drinking behavior (HP:0030082)1.95983694
117Abnormality of the lower motor neuron (HP:0002366)1.93327359
118Congenital hepatic fibrosis (HP:0002612)1.92236212
119Cerebellar dysplasia (HP:0007033)1.91991629
120Abnormality of serum amino acid levels (HP:0003112)1.90752392
121Papilledema (HP:0001085)1.89057856
122Bundle branch block (HP:0011710)1.88992330
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.88087889
124Pachygyria (HP:0001302)1.87849188
125Abnormality of the fovea (HP:0000493)1.87658713
126Severe muscular hypotonia (HP:0006829)1.87217218
127Agitation (HP:0000713)1.87126512
128Severe visual impairment (HP:0001141)1.86502525
129Methylmalonic acidemia (HP:0002912)1.85859651
130Abnormality of the corticospinal tract (HP:0002492)1.85590854
131Urinary bladder sphincter dysfunction (HP:0002839)1.85454005
132Limb dystonia (HP:0002451)1.84341604
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.83962481
134Protruding tongue (HP:0010808)1.83619936
135Congenital, generalized hypertrichosis (HP:0004540)1.83499337
136CNS demyelination (HP:0007305)1.82444343
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.80929807
138Abnormality of macular pigmentation (HP:0008002)1.80661374
139Small hand (HP:0200055)1.78654850
140Concave nail (HP:0001598)1.78422474
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.78411980
142Absent/shortened dynein arms (HP:0200106)1.78411980
143Epileptiform EEG discharges (HP:0011182)1.76653504
144Anencephaly (HP:0002323)1.76108207
145Mutism (HP:0002300)1.76029068
146Genital tract atresia (HP:0001827)1.76002889
147Abnormal respiratory epithelium morphology (HP:0012253)1.75685687
148Abnormal respiratory motile cilium morphology (HP:0005938)1.75685687
149Inability to walk (HP:0002540)1.75542221
150Postaxial foot polydactyly (HP:0001830)1.74749405
151Glycosuria (HP:0003076)1.74654820
152Abnormality of urine glucose concentration (HP:0011016)1.74654820
153Occipital encephalocele (HP:0002085)1.74456593
154Furrowed tongue (HP:0000221)1.74015228
155Cerebral edema (HP:0002181)1.73808655
156Excessive salivation (HP:0003781)1.73344253
157Drooling (HP:0002307)1.73344253
158Disproportionate short-trunk short stature (HP:0003521)1.72279227
159Ulnar claw (HP:0001178)1.70877659
160Myotonia (HP:0002486)1.70000812
161Bradycardia (HP:0001662)1.69755066
162Insomnia (HP:0100785)1.69423908
163EEG with generalized epileptiform discharges (HP:0011198)1.68729746
164Tetraplegia (HP:0002445)1.68428054
165Elfin facies (HP:0004428)1.67580354
166Psychosis (HP:0000709)1.67421333
167Anosmia (HP:0000458)1.67133117
168Incomplete penetrance (HP:0003829)1.66644757
169Absent speech (HP:0001344)1.65772670
170Bradykinesia (HP:0002067)1.65762899
171Metabolic alkalosis (HP:0200114)1.65625199
172Specific learning disability (HP:0001328)1.64379830
173Pancreatic fibrosis (HP:0100732)1.63184572
174Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62208800
175Obstructive sleep apnea (HP:0002870)1.61069861
176Hyperacusis (HP:0010780)1.60609044
177Impaired vibratory sensation (HP:0002495)1.60452002
178Abnormal ciliary motility (HP:0012262)1.58838085
179Blue irides (HP:0000635)1.58287772
180Menstrual irregularities (HP:0000858)1.57742047
181Sleep apnea (HP:0010535)1.57615660
182Prolonged QT interval (HP:0001657)1.57332443
183Abnormality of cochlea (HP:0000375)1.56406122
184Termporal pattern (HP:0011008)1.55171993
185Insidious onset (HP:0003587)1.55171993
186Urinary urgency (HP:0000012)1.54533360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.60094035
2NTRK34.15668746
3CAMKK23.49674736
4TNIK3.32488114
5MAP4K22.98740275
6MAP3K92.67926363
7MAP2K72.57589168
8ZAK2.56353099
9TAOK32.54626035
10CAMKK12.51429242
11BMPR1B2.43100577
12DAPK22.40817085
13INSRR2.38337586
14MAP3K42.27706954
15GRK12.26874603
16RIPK12.21497309
17CASK2.17934130
18SGK22.13406575
19MINK12.11867261
20LMTK22.06455400
21CDK192.03055629
22WNK41.94192238
23NTRK21.92318391
24WNK31.86947114
25RIPK41.80948822
26ACVR1B1.80827463
27BCKDK1.79127693
28SGK4941.78939616
29SGK2231.78939616
30PINK11.76606776
31MAPKAPK31.73180844
32SGK31.71369737
33CSNK1G21.69865858
34CSNK1G31.68887294
35STK381.67446031
36EPHA41.66819191
37WNK11.64829519
38OXSR11.53478040
39TLK11.52021469
40CSNK1G11.50931749
41MARK11.44611564
42CAMK11.42747645
43MKNK21.40317812
44PLK21.40147791
45MAP2K41.37197596
46NUAK11.36179098
47CSNK1A1L1.34246637
48PRKD31.32535437
49DYRK21.31158967
50MAPK131.30345873
51MUSK1.29022655
52PRKCG1.27713019
53AKT31.26393710
54PAK61.25660347
55MAP3K131.23726285
56GRK51.21025000
57VRK21.19358927
58SIK31.16281796
59PHKG11.16079248
60PHKG21.16079248
61STK38L1.15199201
62MAP3K121.12468579
63CDK51.10418203
64PDK21.07922638
65STK161.07750478
66CAMK41.06675415
67TXK1.05167633
68PRPF4B1.05000506
69KSR11.04480112
70KSR21.04407380
71NEK61.03440472
72CAMK1G1.02674314
73SIK20.99652908
74BMPR20.98415312
75MAP3K20.98271664
76CDC42BPA0.96428548
77PRKCH0.94340329
78DAPK10.93544665
79PIK3CA0.93170721
80SGK10.93093265
81ADRBK10.91886543
82VRK10.89807428
83TNK20.85026707
84FGFR20.82516142
85TRIM280.82250277
86PDK10.80804481
87NEK20.80105965
88ERBB30.78148792
89BCR0.77735320
90TAF10.76415111
91STK110.76159975
92CAMK2A0.72331963
93RET0.71475186
94NTRK10.70382614
95PDK40.69195801
96PDK30.69195801
97RPS6KA50.68269845
98PLK30.67502010
99YES10.66352668
100CAMK2B0.65121157
101PTK2B0.65012825
102KIT0.64929080
103PDPK10.63768489
104CAMK2G0.63609326
105CSNK1A10.63138106
106MAP2K60.62617893
107PRKCE0.61428024
108EPHA30.59721581
109TGFBR10.59693164
110MARK20.59634557
111CAMK2D0.59119918
112PKN10.57613107
113SCYL20.56844364
114UHMK10.56103331
115MAPKAPK50.55591409
116WEE10.54962723
117PIM20.54802524
118CAMK1D0.52583515
119BUB10.52086045
120TYRO30.51593919
121DYRK30.50463701
122DYRK1A0.48905803
123RPS6KB10.48877326
124PIK3CG0.48800137
125STK390.48352626
126ALK0.47798243
127ATR0.47210251
128ADRBK20.46963941
129CSNK1D0.46595573
130ROCK20.46496613
131FLT30.46103104
132RPS6KA30.45715889
133PRKCI0.43611860
134TIE10.43244570
135FYN0.42968416
136PRKG10.41253340
137CDK180.40972025
138MST40.39418962
139PRKAA10.38982967
140PRKACA0.38977477
141AKT20.38308986
142CDK150.37821995
143PLK10.37682845
144BRSK20.37080736
145PRKCB0.36983149
146CHEK20.36238918
147MAPK100.35137201
148PRKACB0.34411685
149CSNK1E0.33975993
150CDK11A0.33911737
151MAP3K110.33803915
152HIPK20.33797872
153MAPK70.33592162
154PAK30.33348366
155PLK40.33253014
156CCNB10.33247980
157PRKCA0.32852944
158MKNK10.32815998
159CDK30.32039726
160TEC0.31863908
161PRKCQ0.28617032
162EIF2AK30.27279359

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94977470
2Oxidative phosphorylation_Homo sapiens_hsa001902.93744781
3Synaptic vesicle cycle_Homo sapiens_hsa047212.89647550
4RNA polymerase_Homo sapiens_hsa030202.89108138
5Glutamatergic synapse_Homo sapiens_hsa047242.70735469
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69859504
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68861560
8Circadian entrainment_Homo sapiens_hsa047132.67208984
9Long-term potentiation_Homo sapiens_hsa047202.60467245
10GABAergic synapse_Homo sapiens_hsa047272.49913096
11Morphine addiction_Homo sapiens_hsa050322.48723573
12Olfactory transduction_Homo sapiens_hsa047402.45039125
13Parkinsons disease_Homo sapiens_hsa050122.35250985
14Salivary secretion_Homo sapiens_hsa049702.33616889
15Taste transduction_Homo sapiens_hsa047422.24271377
16Gastric acid secretion_Homo sapiens_hsa049712.11114038
17Long-term depression_Homo sapiens_hsa047302.04574931
18Amphetamine addiction_Homo sapiens_hsa050312.03996249
19Butanoate metabolism_Homo sapiens_hsa006502.00782679
20Homologous recombination_Homo sapiens_hsa034401.97637626
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93903071
22Insulin secretion_Homo sapiens_hsa049111.92459850
23Linoleic acid metabolism_Homo sapiens_hsa005911.90599862
24Selenocompound metabolism_Homo sapiens_hsa004501.89492858
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88759413
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88539630
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82698037
28Basal transcription factors_Homo sapiens_hsa030221.82409223
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81304905
30Dopaminergic synapse_Homo sapiens_hsa047281.74111276
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71956361
32Cholinergic synapse_Homo sapiens_hsa047251.71238858
33Protein export_Homo sapiens_hsa030601.67058558
34Calcium signaling pathway_Homo sapiens_hsa040201.65807782
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.59789527
36Huntingtons disease_Homo sapiens_hsa050161.59665203
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57908577
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56886671
39Fanconi anemia pathway_Homo sapiens_hsa034601.56618513
40Non-homologous end-joining_Homo sapiens_hsa034501.55788891
41Ether lipid metabolism_Homo sapiens_hsa005651.49273175
42Renin secretion_Homo sapiens_hsa049241.49257826
43Alzheimers disease_Homo sapiens_hsa050101.49215857
44Oxytocin signaling pathway_Homo sapiens_hsa049211.46743705
45Caffeine metabolism_Homo sapiens_hsa002321.44604637
46Serotonergic synapse_Homo sapiens_hsa047261.40516635
47Propanoate metabolism_Homo sapiens_hsa006401.39554586
48cAMP signaling pathway_Homo sapiens_hsa040241.38700729
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.37132159
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33752453
51Tryptophan metabolism_Homo sapiens_hsa003801.27990620
52ABC transporters_Homo sapiens_hsa020101.25921835
53Proteasome_Homo sapiens_hsa030501.24408192
54Pyrimidine metabolism_Homo sapiens_hsa002401.23777849
55Nitrogen metabolism_Homo sapiens_hsa009101.19353017
56Pancreatic secretion_Homo sapiens_hsa049721.18822069
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17383562
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16665597
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16528560
60Type II diabetes mellitus_Homo sapiens_hsa049301.16195285
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15359319
62Gap junction_Homo sapiens_hsa045401.14168156
63GnRH signaling pathway_Homo sapiens_hsa049121.12653293
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10958271
65Circadian rhythm_Homo sapiens_hsa047101.10471444
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09868959
67Purine metabolism_Homo sapiens_hsa002301.09444725
68Cocaine addiction_Homo sapiens_hsa050301.09320684
69Peroxisome_Homo sapiens_hsa041461.08926146
70Collecting duct acid secretion_Homo sapiens_hsa049661.06808103
71cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05993435
72Primary bile acid biosynthesis_Homo sapiens_hsa001201.04370248
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04238288
74Primary immunodeficiency_Homo sapiens_hsa053401.04218502
75Thyroid hormone synthesis_Homo sapiens_hsa049181.03671037
76One carbon pool by folate_Homo sapiens_hsa006701.00781753
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00620351
78Melanogenesis_Homo sapiens_hsa049161.00097629
79Estrogen signaling pathway_Homo sapiens_hsa049150.98346644
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96517059
81RNA degradation_Homo sapiens_hsa030180.96495371
82Inositol phosphate metabolism_Homo sapiens_hsa005620.94505594
83beta-Alanine metabolism_Homo sapiens_hsa004100.94204876
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93375893
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92323964
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92123842
87Cardiac muscle contraction_Homo sapiens_hsa042600.90767892
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.90388462
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90083267
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89504361
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88282900
92ErbB signaling pathway_Homo sapiens_hsa040120.86920059
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84623621
94Fat digestion and absorption_Homo sapiens_hsa049750.84239917
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82759941
96Phototransduction_Homo sapiens_hsa047440.82125146
97Regulation of autophagy_Homo sapiens_hsa041400.81559895
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.81461111
99Dilated cardiomyopathy_Homo sapiens_hsa054140.79020884
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.78935480
101Fatty acid biosynthesis_Homo sapiens_hsa000610.76461904
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76005416
103Glioma_Homo sapiens_hsa052140.75955328
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75237654
105Metabolic pathways_Homo sapiens_hsa011000.74437595
106Retinol metabolism_Homo sapiens_hsa008300.72233421
107Base excision repair_Homo sapiens_hsa034100.71026802
108Dorso-ventral axis formation_Homo sapiens_hsa043200.70614464
109Chemical carcinogenesis_Homo sapiens_hsa052040.69656276
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69527187
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66868654
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66814931
113Choline metabolism in cancer_Homo sapiens_hsa052310.66065079
114Arachidonic acid metabolism_Homo sapiens_hsa005900.66042118
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.64311366
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.62228419
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62203041
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62053184
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59785425
120Glucagon signaling pathway_Homo sapiens_hsa049220.59629648
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58930555
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58302732
123MAPK signaling pathway_Homo sapiens_hsa040100.57788891
124Axon guidance_Homo sapiens_hsa043600.55691375
125Vibrio cholerae infection_Homo sapiens_hsa051100.54864063
126Histidine metabolism_Homo sapiens_hsa003400.54690728
127Rap1 signaling pathway_Homo sapiens_hsa040150.54532061
128Ribosome_Homo sapiens_hsa030100.53839414
129Glycerolipid metabolism_Homo sapiens_hsa005610.50743790
130Oocyte meiosis_Homo sapiens_hsa041140.50618138
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.49698701
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49553998
133Steroid biosynthesis_Homo sapiens_hsa001000.49122472
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48973153
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48169568
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46090546
137mTOR signaling pathway_Homo sapiens_hsa041500.45896543
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.45461921
139Sulfur relay system_Homo sapiens_hsa041220.43729223
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42284849
141Bile secretion_Homo sapiens_hsa049760.42057865
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41790282
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41174531
144Ras signaling pathway_Homo sapiens_hsa040140.41112224
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39974495
146Insulin signaling pathway_Homo sapiens_hsa049100.38196434
147Ovarian steroidogenesis_Homo sapiens_hsa049130.37334261
148Wnt signaling pathway_Homo sapiens_hsa043100.37173382
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.36032018
150Alcoholism_Homo sapiens_hsa050340.34876148
151Nucleotide excision repair_Homo sapiens_hsa034200.34762856
152Asthma_Homo sapiens_hsa053100.34399865
153Endometrial cancer_Homo sapiens_hsa052130.34130703
154Platelet activation_Homo sapiens_hsa046110.33847396
155Prolactin signaling pathway_Homo sapiens_hsa049170.33153747
156Non-small cell lung cancer_Homo sapiens_hsa052230.31772001
157Chemokine signaling pathway_Homo sapiens_hsa040620.31744006
158Melanoma_Homo sapiens_hsa052180.30738425
159Mineral absorption_Homo sapiens_hsa049780.27817131
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.24070310
161Tight junction_Homo sapiens_hsa045300.22098041
162FoxO signaling pathway_Homo sapiens_hsa040680.22032087
163Type I diabetes mellitus_Homo sapiens_hsa049400.21375355
164Proteoglycans in cancer_Homo sapiens_hsa052050.18880083

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »