LTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antibacterial humoral response (GO:0019731)9.52078668
2leukocyte aggregation (GO:0070486)9.17501329
3* antimicrobial humoral response (GO:0019730)8.86596669
4* mucosal immune response (GO:0002385)8.37249053
5* organ or tissue specific immune response (GO:0002251)7.77065764
6detection of bacterium (GO:0016045)6.80352806
7sequestering of metal ion (GO:0051238)6.72490645
8detection of other organism (GO:0098543)6.49183144
9* defense response to fungus (GO:0050832)6.35852890
10response to peptidoglycan (GO:0032494)6.28199332
11disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.25279219
12killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.25279219
13neutrophil activation involved in immune response (GO:0002283)5.71242638
14intracellular estrogen receptor signaling pathway (GO:0030520)5.56487835
15regulation of female gonad development (GO:2000194)5.49995165
16macrophage differentiation (GO:0030225)5.11434698
17respiratory burst (GO:0045730)5.10510349
18* response to fungus (GO:0009620)5.08134418
19cellular extravasation (GO:0045123)5.06996873
20cell killing (GO:0001906)5.06490725
21citrulline biosynthetic process (GO:0019240)5.04495861
22positive regulation of steroid hormone secretion (GO:2000833)5.01226253
23chronic inflammatory response (GO:0002544)4.98066817
24neutrophil activation (GO:0042119)4.98001438
25pentose-phosphate shunt (GO:0006098)4.97573368
26neutrophil mediated immunity (GO:0002446)4.69697305
27disruption of cells of other organism (GO:0044364)4.59482224
28killing of cells of other organism (GO:0031640)4.59482224
29negative regulation of erythrocyte differentiation (GO:0045647)4.52277944
30NADPH regeneration (GO:0006740)4.49185280
31granulocyte activation (GO:0036230)4.47181960
32neutrophil chemotaxis (GO:0030593)4.40250081
33cellular response to interleukin-6 (GO:0071354)4.36217192
34production of molecular mediator involved in inflammatory response (GO:0002532)4.28440026
35neutrophil migration (GO:1990266)4.27835430
36response to methylmercury (GO:0051597)4.26045629
37hydrogen peroxide biosynthetic process (GO:0050665)4.19320623
38hepatocyte differentiation (GO:0070365)4.16655517
39interferon-gamma secretion (GO:0072643)4.12728085
40endodermal cell differentiation (GO:0035987)4.08795234
41regulation of myeloid leukocyte mediated immunity (GO:0002886)4.08332130
42superoxide anion generation (GO:0042554)4.02495322
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.01574867
44diterpenoid biosynthetic process (GO:0016102)3.99227607
45positive regulation of vesicle fusion (GO:0031340)3.95996887
46positive regulation of p38MAPK cascade (GO:1900745)3.93706294
47detection of external biotic stimulus (GO:0098581)3.87244278
48regulation of leukocyte degranulation (GO:0043300)3.87216495
49negative regulation of interleukin-6 production (GO:0032715)3.83539606
50regulation of regulated secretory pathway (GO:1903305)3.81995214
51granulocyte migration (GO:0097530)3.80276343
52regulation of natural killer cell differentiation (GO:0032823)3.78838936
53reactive oxygen species biosynthetic process (GO:1903409)3.77011674
54hemidesmosome assembly (GO:0031581)3.75128210
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.72254886
56response to interleukin-6 (GO:0070741)3.72234322
57granulocyte chemotaxis (GO:0071621)3.70123610
58* negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.65057526
59negative regulation of tumor necrosis factor production (GO:0032720)3.65057526
60glucose catabolic process (GO:0006007)3.56083157
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55710050
62negative regulation of cell killing (GO:0031342)3.55710050
63positive regulation of mast cell activation (GO:0033005)3.55302828
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51237162
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51237162
66response to manganese ion (GO:0010042)3.48922794
67defense response to Gram-positive bacterium (GO:0050830)3.48168022
68myeloid leukocyte mediated immunity (GO:0002444)3.47655746
69* response to bacterium (GO:0009617)3.47109684
70oxygen transport (GO:0015671)3.46753390
71hemoglobin metabolic process (GO:0020027)3.43463702
72protoporphyrinogen IX metabolic process (GO:0046501)3.32620402
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.32287674
74positive regulation of smooth muscle cell migration (GO:0014911)3.28725344
75leukocyte cell-cell adhesion (GO:0007159)3.28068329
76leukocyte degranulation (GO:0043299)3.27255752
77regulation of B cell receptor signaling pathway (GO:0050855)3.26764441
78growth hormone receptor signaling pathway (GO:0060396)3.25458284
79regulation of mast cell activation (GO:0033003)3.25378642
80detection of biotic stimulus (GO:0009595)3.23026584
81positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.21037739
82protoporphyrinogen IX biosynthetic process (GO:0006782)3.19571574
83regulation of feeding behavior (GO:0060259)3.17898164
84positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.16471752
85modulation of growth of symbiont involved in interaction with host (GO:0044144)3.15235557
86regulation of growth of symbiont in host (GO:0044126)3.15235557
87negative regulation of growth of symbiont in host (GO:0044130)3.15235557
88negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.15235557
89positive regulation of lamellipodium assembly (GO:0010592)3.14426380
90cell wall macromolecule catabolic process (GO:0016998)3.10926522
91opsonization (GO:0008228)3.10497521
92positive regulation of regulated secretory pathway (GO:1903307)3.07954540
93defense response to Gram-negative bacterium (GO:0050829)3.06680099
94modification of morphology or physiology of other organism (GO:0035821)3.03748767
95regulation of steroid hormone secretion (GO:2000831)3.02577988
96macrophage activation involved in immune response (GO:0002281)3.01359580
973-UTR-mediated mRNA stabilization (GO:0070935)2.98788074
98leukotriene metabolic process (GO:0006691)2.97683401
99NADP metabolic process (GO:0006739)2.97487430
100* phagosome maturation (GO:0090382)2.97144633
101activated T cell proliferation (GO:0050798)2.96066037
102myeloid cell development (GO:0061515)2.95629932
103positive regulation of gamma-delta T cell activation (GO:0046645)2.95621944
104negative regulation of phagocytosis (GO:0050765)2.94041156
105citrulline metabolic process (GO:0000052)2.93807611
1064-hydroxyproline metabolic process (GO:0019471)2.93694216
107regulation of macrophage activation (GO:0043030)2.92455433
108regulation of receptor binding (GO:1900120)2.91069481
109negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90495200
110modification by host of symbiont morphology or physiology (GO:0051851)2.90289452
111positive regulation by symbiont of host defense response (GO:0052509)2.86868533
112modulation by symbiont of host defense response (GO:0052031)2.86868533
113modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.86868533
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.86868533
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.86868533
116modulation by symbiont of host immune response (GO:0052553)2.86868533
117regulation of mast cell degranulation (GO:0043304)2.86851068
118* defense response to bacterium (GO:0042742)2.86291233
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85284034
120myeloid leukocyte migration (GO:0097529)2.85106236
121positive regulation of leukocyte degranulation (GO:0043302)2.84321366
122embryonic process involved in female pregnancy (GO:0060136)2.84130402
123detection of molecule of bacterial origin (GO:0032490)2.83715658
124regulation of p38MAPK cascade (GO:1900744)2.83060477
125keratinocyte differentiation (GO:0030216)2.82173951
126regulation of interleukin-8 secretion (GO:2000482)2.81721702
127antigen processing and presentation of endogenous antigen (GO:0019883)2.81661886
128glucosamine-containing compound catabolic process (GO:1901072)2.78368147
129terpenoid biosynthetic process (GO:0016114)2.77722215
130one-carbon compound transport (GO:0019755)2.76671750
131positive regulation of mast cell degranulation (GO:0043306)2.75300156
132positive regulation of mast cell activation involved in immune response (GO:0033008)2.75300156
133gas transport (GO:0015669)2.74567328
134amino sugar catabolic process (GO:0046348)2.72597698
135leukotriene biosynthetic process (GO:0019370)2.72380682
136regulation of vitamin D biosynthetic process (GO:0060556)2.72350123
137cellular response to growth hormone stimulus (GO:0071378)2.72328345
138negative regulation of interleukin-8 production (GO:0032717)2.70929295
139positive regulation of actin cytoskeleton reorganization (GO:2000251)2.70921865
140regulation of mast cell activation involved in immune response (GO:0033006)2.69841212
141interaction with symbiont (GO:0051702)2.69237671
142keratinization (GO:0031424)2.69232367
143regulation of phagocytosis (GO:0050764)2.69197876
144homotypic cell-cell adhesion (GO:0034109)2.66392103
145regulation of respiratory burst (GO:0060263)2.66140100
146negative regulation of T-helper cell differentiation (GO:0045623)2.65745086
147negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.65745086
148regulation of podosome assembly (GO:0071801)2.65489679
149regulation of interleukin-8 biosynthetic process (GO:0045414)2.61283742
150* innate immune response in mucosa (GO:0002227)10.3530014
151leukocyte migration involved in inflammatory response (GO:0002523)10.3202512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.34749485
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.20776020
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.68935426
4GATA1_22025678_ChIP-Seq_K562_Human3.55775002
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.13014344
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87983484
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.82953077
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80696287
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.79051329
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.78113974
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.71609196
12BRD4_27068464_Chip-Seq_AML-cells_Mouse2.57771848
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48428844
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47466919
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37685088
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28114741
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.21688745
18SCL_19346495_ChIP-Seq_HPC-7_Human2.21073917
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.14755496
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13919541
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09839466
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07439594
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05120455
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.03927371
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00633745
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.91330271
27VDR_21846776_ChIP-Seq_THP-1_Human1.85510803
28VDR_24763502_ChIP-Seq_THP-1_Human1.81521546
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74360762
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71915055
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.71835219
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65998874
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.64639891
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64039260
35SPI1_23547873_ChIP-Seq_NB4_Human1.63918702
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63187814
37SPI1_23127762_ChIP-Seq_K562_Human1.61272366
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60250059
39MYB_26560356_Chip-Seq_TH2_Human1.60090021
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59316532
41TCF7_22412390_ChIP-Seq_EML_Mouse1.58152546
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57345531
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57345531
44RACK7_27058665_Chip-Seq_MCF-7_Human1.57336602
45* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.57013765
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.55885968
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.53134635
48MAF_26560356_Chip-Seq_TH1_Human1.51486497
49SOX2_20726797_ChIP-Seq_SW620_Human1.49454023
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48334695
51PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48304105
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46197096
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45065088
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44566771
55VDR_24787735_ChIP-Seq_THP-1_Human1.44548382
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44002798
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43013695
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42263933
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.41764202
60* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40645356
61UTX_26944678_Chip-Seq_JUKART_Human1.39887258
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39215511
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.39146447
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35735443
65GATA2_19941826_ChIP-Seq_K562_Human1.35551947
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35182677
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33404551
68GATA1_19941826_ChIP-Seq_K562_Human1.33350920
69LXR_22292898_ChIP-Seq_THP-1_Human1.33327101
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33292923
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32328771
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32071391
73* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31414221
74RUNX_20019798_ChIP-Seq_JUKART_Human1.30025928
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29124238
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.28345382
77CLOCK_20551151_ChIP-Seq_293T_Human1.26738092
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26615000
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25453373
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.25054407
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22841167
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21876357
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21490132
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.21433751
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19258260
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17485237
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16679016
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16634664
89KLF5_25053715_ChIP-Seq_YYC3_Human1.16565720
90GATA4_25053715_ChIP-Seq_YYC3_Human1.14442614
91KDM2B_26808549_Chip-Seq_DND41_Human1.14128301
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14014538
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13686078
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12092768
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10707800
96PU_27001747_Chip-Seq_BMDM_Mouse1.10570087
97GATA3_27048872_Chip-Seq_THYMUS_Human1.09533157
98ATF3_27146783_Chip-Seq_COLON_Human1.09245179
99MAF_26560356_Chip-Seq_TH2_Human1.08579347
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08399142
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08187584
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08063076
103* BCOR_27268052_Chip-Seq_Bcells_Human1.07773372
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07447864
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06543238
106NCOR1_26117541_ChIP-Seq_K562_Human1.06140123
107AR_21909140_ChIP-Seq_LNCAP_Human1.06121593
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05631481
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04588141
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04359273
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04067833
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03390164
113KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03100908
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02428817
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02043634
116MYB_26560356_Chip-Seq_TH1_Human1.01631330
117MYC_22102868_ChIP-Seq_BL_Human1.01467000
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01132250
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00823444
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99297825
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99168607
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99026319
123ZNF263_19887448_ChIP-Seq_K562_Human0.98800023
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98693914
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97939590
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.97771839
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.95213222
128CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95131596
129PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93395440
130KDM2B_26808549_Chip-Seq_K562_Human0.90681280
131SPI1_20517297_ChIP-Seq_HL60_Human0.89854969
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88556794
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87558602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.11067386
2MP0010234_abnormal_vibrissa_follicle4.62977353
3MP0003436_decreased_susceptibility_to4.51176249
4MP0009785_altered_susceptibility_to3.69415130
5MP0009278_abnormal_bone_marrow3.58494764
6MP0002837_dystrophic_cardiac_calcinosis2.87527635
7MP0002419_abnormal_innate_immunity2.86644867
8MP0003183_abnormal_peptide_metabolism2.71445321
9MP0005167_abnormal_blood-brain_barrier2.63881535
10MP0003566_abnormal_cell_adhesion2.58209630
11MP0003300_gastrointestinal_ulcer2.42199661
12MP0001533_abnormal_skeleton_physiology2.37582150
13MP0004147_increased_porphyrin_level2.27171824
14MP0005025_abnormal_response_to2.19959358
15MP0008260_abnormal_autophagy2.18652194
16MP0000343_altered_response_to2.11049658
17MP0003075_altered_response_to2.03108977
18MP0001853_heart_inflammation1.98386151
19MP0005023_abnormal_wound_healing1.90561414
20MP0004883_abnormal_blood_vessel1.88807272
21MP0006054_spinal_hemorrhage1.87357200
22MP0000858_altered_metastatic_potential1.86396625
23MP0001851_eye_inflammation1.83858295
24MP0004264_abnormal_extraembryonic_tissu1.78575223
25MP0005397_hematopoietic_system_phenotyp1.73696544
26MP0001545_abnormal_hematopoietic_system1.73696544
27MP0002405_respiratory_system_inflammati1.73277123
28MP0003453_abnormal_keratinocyte_physiol1.72340239
29MP0003950_abnormal_plasma_membrane1.70625002
30MP0001881_abnormal_mammary_gland1.69325342
31MP0009764_decreased_sensitivity_to1.67487571
32MP0005464_abnormal_platelet_physiology1.64735498
33MP0005076_abnormal_cell_differentiation1.64421477
34MP0005164_abnormal_response_to1.57506060
35MP0000465_gastrointestinal_hemorrhage1.57303929
36MP0002166_altered_tumor_susceptibility1.53980798
37MP0000685_abnormal_immune_system1.49633148
38MP0001845_abnormal_inflammatory_respons1.48333355
39MP0004808_abnormal_hematopoietic_stem1.47358049
40MP0002452_abnormal_antigen_presenting1.46048568
41MP0004947_skin_inflammation1.44651348
42MP0003279_aneurysm1.44413776
43MP0001819_abnormal_immune_cell1.44207132
44MP0005000_abnormal_immune_tolerance1.43673656
45MP0002420_abnormal_adaptive_immunity1.43268481
46MP0010155_abnormal_intestine_physiology1.42809546
47MP0005166_decreased_susceptibility_to1.42248888
48MP0002933_joint_inflammation1.40441632
49MP0010678_abnormal_skin_adnexa1.40282043
50MP0002148_abnormal_hypersensitivity_rea1.40178732
51MP0003221_abnormal_cardiomyocyte_apopto1.38619396
52MP0003448_altered_tumor_morphology1.38530648
53MP0004130_abnormal_muscle_cell1.37910094
54MP0002877_abnormal_melanocyte_morpholog1.37254452
55MP0003091_abnormal_cell_migration1.37125033
56MP0002254_reproductive_system_inflammat1.36545551
57MP0010352_gastrointestinal_tract_polyps1.32186914
58MP0001216_abnormal_epidermal_layer1.29854106
59MP0003724_increased_susceptibility_to1.29675040
60MP0001849_ear_inflammation1.29393604
61MP0003828_pulmonary_edema1.27368765
62MP0001958_emphysema1.26647241
63MP0005083_abnormal_biliary_tract1.25521707
64MP0002796_impaired_skin_barrier1.19583940
65MP0003656_abnormal_erythrocyte_physiolo1.19384457
66MP0001835_abnormal_antigen_presentation1.18949027
67MP0002060_abnormal_skin_morphology1.18773338
68MP0001800_abnormal_humoral_immune1.17000336
69MP0002722_abnormal_immune_system1.15961118
70MP0003763_abnormal_thymus_physiology1.15755111
71MP0005390_skeleton_phenotype1.12564724
72MP0002998_abnormal_bone_remodeling1.11935384
73MP0005248_abnormal_Harderian_gland1.10750449
74MP0002723_abnormal_immune_serum1.08283875
75MP0003191_abnormal_cellular_cholesterol1.08236529
76MP0001790_abnormal_immune_system1.07491316
77MP0005387_immune_system_phenotype1.07491316
78MP0002009_preneoplasia1.07403039
79MP0003866_abnormal_defecation1.07355938
80MP0003806_abnormal_nucleotide_metabolis1.05209066
81MP0002282_abnormal_trachea_morphology1.01440076
82MP0009840_abnormal_foam_cell1.01376407
83MP0009765_abnormal_xenobiotic_induced1.00131680
84MP0003705_abnormal_hypodermis_morpholog0.98633543
85MP0009333_abnormal_splenocyte_physiolog0.95577289
86MP0008469_abnormal_protein_level0.94955465
87MP0002138_abnormal_hepatobiliary_system0.94346781
88MP0005621_abnormal_cell_physiology0.93947047
89MP0002277_abnormal_respiratory_mucosa0.93925501
90* MP0000689_abnormal_spleen_morphology0.91268093
91MP0000716_abnormal_immune_system0.90135106
92MP0000579_abnormal_nail_morphology0.89734415
93MP0002396_abnormal_hematopoietic_system0.88946940
94MP0000627_abnormal_mammary_gland0.88167806
95MP0005058_abnormal_lysosome_morphology0.87904204
96MP0009763_increased_sensitivity_to0.87285514
97MP0004185_abnormal_adipocyte_glucose0.85633125
98MP0000703_abnormal_thymus_morphology0.84235911
99MP0001873_stomach_inflammation0.83925282
100MP0006082_CNS_inflammation0.83219842
101MP0002133_abnormal_respiratory_system0.81337631
102MP0005388_respiratory_system_phenotype0.81337631
103MP0002398_abnormal_bone_marrow0.80943338
104MP0001663_abnormal_digestive_system0.79737370
105MP0005310_abnormal_salivary_gland0.77509270
106MP0000377_abnormal_hair_follicle0.77106377
107MP0009931_abnormal_skin_appearance0.76497098
108MP0003690_abnormal_glial_cell0.75876261
109MP0009115_abnormal_fat_cell0.75319781
110MP0005666_abnormal_adipose_tissue0.75038480
111MP0000490_abnormal_crypts_of0.74313229
112MP0002429_abnormal_blood_cell0.73988259
113MP0002006_tumorigenesis0.73388510
114MP0000537_abnormal_urethra_morphology0.73108482
115MP0005535_abnormal_body_temperature0.72850728
116MP0005409_darkened_coat_color0.71899340
117MP0003045_fibrosis0.71792880
118MP0000920_abnormal_myelination0.71232143
119MP0002098_abnormal_vibrissa_morphology0.70845782
120MP0005501_abnormal_skin_physiology0.70554986
121MP0002971_abnormal_brown_adipose0.69340050
122MP0000249_abnormal_blood_vessel0.67955896
123MP0003638_abnormal_response/metabolism_0.67416271
124MP0004381_abnormal_hair_follicle0.66724341
125MP0010771_integument_phenotype0.66021501
126* MP0000609_abnormal_liver_physiology0.65870876
127MP0003795_abnormal_bone_structure0.63469524
128MP0003172_abnormal_lysosome_physiology0.62901569
129MP0001191_abnormal_skin_condition0.61080654
130MP0005671_abnormal_response_to0.60621563
131MP0005334_abnormal_fat_pad0.57642786
132MP0008004_abnormal_stomach_pH0.57095251
133MP0005165_increased_susceptibility_to0.56938015

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)8.48046018
2Recurrent abscess formation (HP:0002722)7.84951484
3Recurrent gram-negative bacterial infections (HP:0005420)7.70644920
4Recurrent bacterial skin infections (HP:0005406)6.83388013
5Hypochromic microcytic anemia (HP:0004840)5.43110568
6Abnormality of the heme biosynthetic pathway (HP:0010472)5.28666738
7Abnormality of macrophages (HP:0004311)5.28337928
8Gingivitis (HP:0000230)5.01240915
9Systemic lupus erythematosus (HP:0002725)4.93947225
10Chronic obstructive pulmonary disease (HP:0006510)4.78736145
11Obstructive lung disease (HP:0006536)4.78736145
12Mediastinal lymphadenopathy (HP:0100721)4.58292822
13Pustule (HP:0200039)4.48111524
14Poikilocytosis (HP:0004447)4.27973950
15Onycholysis (HP:0001806)4.04024729
16Cellulitis (HP:0100658)3.99638817
17Urticaria (HP:0001025)3.98015495
18Recurrent fungal infections (HP:0002841)3.90045415
19Hypochromic anemia (HP:0001931)3.76811126
20Recurrent skin infections (HP:0001581)3.64227214
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.63039318
22Interstitial pulmonary disease (HP:0006530)3.55848561
23Milia (HP:0001056)3.52109213
24Stomatitis (HP:0010280)3.50602276
25Right ventricular cardiomyopathy (HP:0011663)3.31071422
26Atrophic scars (HP:0001075)3.09754492
27Microcytic anemia (HP:0001935)3.04211338
28Abnormality of iron homeostasis (HP:0011031)3.03439209
29Gastrointestinal infarctions (HP:0005244)3.02918358
30Abnormality of pyrimidine metabolism (HP:0004353)2.96600716
31Abnormality of B cell number (HP:0010975)2.95036109
32Polycythemia (HP:0001901)2.94731363
33Abnormality of the fingertips (HP:0001211)2.94290227
34Myositis (HP:0100614)2.93222135
35Increased serum ferritin (HP:0003281)2.91836415
36Autoimmune thrombocytopenia (HP:0001973)2.85071591
37Amyloidosis (HP:0011034)2.81681129
38Skin ulcer (HP:0200042)2.77949112
39Abnormal platelet volume (HP:0011876)2.77653885
40Anorexia (HP:0002039)2.75517596
41Fragile nails (HP:0001808)2.71102858
42Meningitis (HP:0001287)2.68681001
43B lymphocytopenia (HP:0010976)2.63339061
44Periodontitis (HP:0000704)2.63075658
45Cheilitis (HP:0100825)2.59187761
46Abnormality of transition element cation homeostasis (HP:0011030)2.58283134
47Recurrent cutaneous fungal infections (HP:0011370)2.57999016
48Chronic mucocutaneous candidiasis (HP:0002728)2.57999016
49Increased mean platelet volume (HP:0011877)2.51263586
50Curly hair (HP:0002212)2.47779073
51Osteomyelitis (HP:0002754)2.45518708
52Pili torti (HP:0003777)2.45114812
53Granulocytopenia (HP:0001913)2.44029530
54Abnormality of sodium homeostasis (HP:0010931)2.43824579
55Toxemia of pregnancy (HP:0100603)2.43771343
56Vacuolated lymphocytes (HP:0001922)2.42419473
57Abnormal hemoglobin (HP:0011902)2.40873357
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40599893
59Difficulty running (HP:0009046)2.38250259
60Slow saccadic eye movements (HP:0000514)2.36503186
61Papilledema (HP:0001085)2.36147010
62Hemoptysis (HP:0002105)2.35719908
63Thickened calvaria (HP:0002684)2.35476904
64Retrobulbar optic neuritis (HP:0100654)2.33007947
65Optic neuritis (HP:0100653)2.33007947
66Nasal polyposis (HP:0100582)2.31133384
67Sepsis (HP:0100806)2.31123044
68Pulmonary infiltrates (HP:0002113)2.29990726
69Polygenic inheritance (HP:0010982)2.29972649
70Muscle fiber splitting (HP:0003555)2.28541173
71Increased connective tissue (HP:0009025)2.25495555
72Scanning speech (HP:0002168)2.24874499
73Short femoral neck (HP:0100864)2.24158601
74Abnormality of glycolipid metabolism (HP:0010969)2.22390628
75Abnormality of liposaccharide metabolism (HP:0010968)2.22390628
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.22390628
77Ulnar bowing (HP:0003031)2.22162495
78Aplasia/hypoplasia of the femur (HP:0005613)2.19945620
79Orchitis (HP:0100796)2.19233415
80Diaphragmatic weakness (HP:0009113)2.18634216
81Vascular calcification (HP:0004934)2.16097503
82Glomerulonephritis (HP:0000099)2.16057384
83Alopecia of scalp (HP:0002293)2.15209201
84Pyloric stenosis (HP:0002021)2.14522529
85Hepatosplenomegaly (HP:0001433)2.14490215
86Petechiae (HP:0000967)2.13190147
87Abnormality of the nasal mucosa (HP:0000433)2.11931732
88Plantar hyperkeratosis (HP:0007556)2.10867864
89Abnormality of nucleobase metabolism (HP:0010932)2.07957730
90Cardiovascular calcification (HP:0011915)2.07323340
91Recurrent viral infections (HP:0004429)2.06463641
92Spontaneous hematomas (HP:0007420)2.06108942
93Metaphyseal irregularity (HP:0003025)2.04107437
94Increased cerebral lipofuscin (HP:0011813)2.02763587
95Prolonged bleeding time (HP:0003010)2.01642455
96Gout (HP:0001997)2.01256678
97Episodic fever (HP:0001954)1.99110529
98Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.98717997
99Abnormal blistering of the skin (HP:0008066)1.98160993
100Autoimmune hemolytic anemia (HP:0001890)1.97300316
101Vasculitis (HP:0002633)1.96951946
102Axonal loss (HP:0003447)1.96812404
103Myocardial infarction (HP:0001658)1.95256248
104Hematochezia (HP:0002573)1.94669526
105Hypoplasia of dental enamel (HP:0006297)1.94469763
106Paralysis (HP:0003470)1.94167687
107Metaphyseal cupping (HP:0003021)1.92724374
108Obstructive sleep apnea (HP:0002870)1.91294674
109Nephritis (HP:0000123)1.90170309
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89962448
111Verrucae (HP:0200043)1.89149733
112Papilloma (HP:0012740)1.89149733
113Gingival bleeding (HP:0000225)1.84875834
114Peritonitis (HP:0002586)1.84762290
115Nail dystrophy (HP:0008404)1.83022074
116Cholelithiasis (HP:0001081)1.83008165
117Abnormality of oral frenula (HP:0000190)1.82506174
118Ocular albinism (HP:0001107)1.82223860
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.81830312
120Hypertriglyceridemia (HP:0002155)1.80378318
121Abnormality of complement system (HP:0005339)1.80185119
122Cone-rod dystrophy (HP:0000548)1.80002647
123Abnormal foot bone ossification (HP:0010675)1.79814249
124Acute myeloid leukemia (HP:0004808)1.79593196
125Hypergammaglobulinemia (HP:0010702)1.79295879
126Leukocytosis (HP:0001974)1.78825101
127Skin rash (HP:0000988)1.78351018
128Increased variability in muscle fiber diameter (HP:0003557)1.78036968
129Keratoconjunctivitis sicca (HP:0001097)1.77930431
130Abnormality of skeletal muscle fiber size (HP:0012084)1.77378222
131Eosinophilia (HP:0001880)1.77290572
132Chronic otitis media (HP:0000389)1.76470023
133Purpura (HP:0000979)1.76403128
134Ankyloglossia (HP:0010296)1.75438591
135Congenital ichthyosiform erythroderma (HP:0007431)1.75373947
136Increased IgE level (HP:0003212)1.74336280
137Recurrent pneumonia (HP:0006532)1.74222617
138Osteolytic defects of the hand bones (HP:0009699)1.74129993
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.74129993
140Reticulocytosis (HP:0001923)1.71637172
141Fatigue (HP:0012378)1.70534104
142Inflammation of the large intestine (HP:0002037)1.70041871
143Absent frontal sinuses (HP:0002688)1.67778620
144Dysostosis multiplex (HP:0000943)1.65800366
145Bowed forearm bones (HP:0003956)1.64527814
146Bowing of the arm (HP:0006488)1.64527814
147Subacute progressive viral hepatitis (HP:0006572)1.63719784
148Epistaxis (HP:0000421)1.63229849
149Menorrhagia (HP:0000132)1.62011998
150Abnormality of the distal phalanges of the toes (HP:0010182)1.61994498
151Glomerulosclerosis (HP:0000096)1.60806878
152Chest pain (HP:0100749)1.60796809
153Hypermelanotic macule (HP:0001034)1.59695457
154Gastrointestinal inflammation (HP:0004386)1.59328851
155IgM deficiency (HP:0002850)1.59164463
156Elevated erythrocyte sedimentation rate (HP:0003565)1.57268545
157Persistence of primary teeth (HP:0006335)1.56652217
158Arterial tortuosity (HP:0005116)1.55778253
159Abnormality of alkaline phosphatase activity (HP:0004379)1.54559221
160Keratoconjunctivitis (HP:0001096)1.54172444
161Cervical subluxation (HP:0003308)1.53929700
162Hemorrhage of the eye (HP:0011885)1.53021327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.29769055
2PRPF4B4.24331219
3TRPM74.15875902
4EPHB14.03155834
5MAP3K63.93677290
6ERBB33.82419414
7IRAK43.49747695
8MAP3K92.84436244
9ERN12.47356447
10TRIB32.29537877
11PIK3CG2.26734905
12CSK2.16555161
13IRAK12.16355422
14PTK62.08697777
15RIPK42.07364136
16PTK22.06613160
17FGR2.04016339
18STK101.94399327
19PAK41.93274658
20BLK1.90449532
21FRK1.88252192
22TTN1.81846742
23MAP2K31.80774971
24MAP3K121.75639992
25GRK61.75541168
26BTK1.73006555
27PKN21.71419948
28MAP3K31.65919703
29LRRK21.65803945
30ZAP701.54067261
31TNK21.50873058
32HCK1.49821709
33PIK3CA1.48137551
34CDK121.45712135
35TESK11.43928235
36FES1.42959132
37TAOK21.41075843
38KSR21.40997394
39CLK11.38819704
40TESK21.32153620
41RIPK11.29747470
42SIK31.27813064
43TGFBR21.21055465
44PRKG21.19932145
45MARK21.16161282
46IRAK21.15858937
47MAP3K21.15105705
48TEC1.11413507
49MST41.11359471
50FER1.07202502
51IKBKE1.00038324
52ALK0.97437053
53EPHA30.96954441
54BRSK20.93984768
55MAP2K40.93448912
56MATK0.93201692
57TAOK10.91706034
58MAP3K50.91215578
59KDR0.89629276
60HIPK20.89122065
61MARK30.88901349
62TYK20.87652775
63MST1R0.87320198
64JAK30.80929405
65MAP4K10.77216578
66NLK0.76432638
67KIT0.74856611
68BMPR20.71972183
69ITK0.71637271
70BMX0.71169863
71MAP3K10.70806514
72YES10.70619328
73SIK10.67491384
74MAPK120.65627280
75EPHB20.64748587
76AKT30.62926328
77STK40.62628322
78CAMK1D0.61577121
79EGFR0.59724457
80PDGFRB0.59410228
81FGFR30.59304903
82RAF10.59263157
83FYN0.57361831
84PTK2B0.55898881
85SMG10.55285332
86MAP3K130.54867987
87PRKD20.54139121
88SGK20.53629533
89IKBKB0.53481528
90MTOR0.53042197
91MAP3K110.52995733
92IRAK30.52968689
93SIK20.52845908
94MAP3K80.52633352
95MAP2K60.51940324
96TBK10.51889318
97DMPK0.51834496
98LCK0.50380518
99FGFR10.49902306
100EEF2K0.49898560
101CSF1R0.47835366
102MAPK40.47471440
103CAMK1G0.46842446
104FGFR40.45308473
105JAK20.44866816
106TXK0.44727833
107ABL10.44600047
108MAP2K10.43754970
109SRC0.43512522
110PRKCD0.42849903
111MAP2K20.39636084
112MAPKAPK20.39609621
113PAK30.38477582
114MAPK70.38451875
115SGK30.37799222
116BRD40.37094723
117MAP3K140.36159423
118PDPK10.36104401
119LIMK10.35885663
120GRK10.35231446
121RPS6KA20.34732546
122KSR10.34665002
123CDK60.34214993
124STK110.33635077
125MAPK110.32808756
126RPS6KL10.32607179
127RPS6KC10.32607179
128CHUK0.32490799
129RPS6KA60.31711394
130SYK0.29665516
131IGF1R0.29484662
132ERBB20.28827673
133RPS6KA40.28498847
134LYN0.27980346
135PRKAA20.27909643
136RET0.27815959
137RPS6KA10.27587088
138PRKCH0.25659864
139JAK10.23966378

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.30017464
2Leukocyte transendothelial migration_Homo sapiens_hsa046703.22265441
3Staphylococcus aureus infection_Homo sapiens_hsa051502.86555038
4Caffeine metabolism_Homo sapiens_hsa002322.72498189
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04301733
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.01605382
7Osteoclast differentiation_Homo sapiens_hsa043801.96910215
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.94982506
9Shigellosis_Homo sapiens_hsa051311.93992360
10Galactose metabolism_Homo sapiens_hsa000521.85976129
11Histidine metabolism_Homo sapiens_hsa003401.75048684
12Pertussis_Homo sapiens_hsa051331.73049027
13Bladder cancer_Homo sapiens_hsa052191.69067753
14Toxoplasmosis_Homo sapiens_hsa051451.62197890
15Amoebiasis_Homo sapiens_hsa051461.59446802
16Tuberculosis_Homo sapiens_hsa051521.58555813
17Adherens junction_Homo sapiens_hsa045201.54016479
18Salmonella infection_Homo sapiens_hsa051321.51207295
19Pentose phosphate pathway_Homo sapiens_hsa000301.49652934
20Chemokine signaling pathway_Homo sapiens_hsa040621.43882615
21Platelet activation_Homo sapiens_hsa046111.41436929
22Pancreatic cancer_Homo sapiens_hsa052121.40470418
23Hematopoietic cell lineage_Homo sapiens_hsa046401.38544353
24VEGF signaling pathway_Homo sapiens_hsa043701.38264072
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34149279
26B cell receptor signaling pathway_Homo sapiens_hsa046621.32707643
27Proteoglycans in cancer_Homo sapiens_hsa052051.27110695
28TNF signaling pathway_Homo sapiens_hsa046681.25822435
29Phagosome_Homo sapiens_hsa041451.25794039
30Glutathione metabolism_Homo sapiens_hsa004801.25335056
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19808772
32Focal adhesion_Homo sapiens_hsa045101.18070159
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17363283
34Asthma_Homo sapiens_hsa053101.15822564
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13880034
36Legionellosis_Homo sapiens_hsa051341.13596334
37Acute myeloid leukemia_Homo sapiens_hsa052211.11636223
38Chronic myeloid leukemia_Homo sapiens_hsa052201.09549852
39Malaria_Homo sapiens_hsa051441.08146339
40Small cell lung cancer_Homo sapiens_hsa052221.07228739
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06869228
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06363515
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.06209401
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05705596
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03651204
46Renal cell carcinoma_Homo sapiens_hsa052110.99005839
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98881843
48Insulin resistance_Homo sapiens_hsa049310.98423579
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94836055
50Viral myocarditis_Homo sapiens_hsa054160.92823529
51Nitrogen metabolism_Homo sapiens_hsa009100.88396801
52Hepatitis C_Homo sapiens_hsa051600.87420178
53Prostate cancer_Homo sapiens_hsa052150.87342095
54GnRH signaling pathway_Homo sapiens_hsa049120.87073466
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86482972
56ECM-receptor interaction_Homo sapiens_hsa045120.86148716
57Choline metabolism in cancer_Homo sapiens_hsa052310.85340034
58Hepatitis B_Homo sapiens_hsa051610.85325864
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85014887
60Fatty acid biosynthesis_Homo sapiens_hsa000610.84919083
61Estrogen signaling pathway_Homo sapiens_hsa049150.84483221
62Type II diabetes mellitus_Homo sapiens_hsa049300.84341682
63Chemical carcinogenesis_Homo sapiens_hsa052040.83261934
64Rap1 signaling pathway_Homo sapiens_hsa040150.83070887
65T cell receptor signaling pathway_Homo sapiens_hsa046600.82524996
66Salivary secretion_Homo sapiens_hsa049700.82231040
67African trypanosomiasis_Homo sapiens_hsa051430.82130079
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80356219
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.79772612
70Non-small cell lung cancer_Homo sapiens_hsa052230.78313627
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78226013
72Endocytosis_Homo sapiens_hsa041440.77516154
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77455404
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76724433
75Prolactin signaling pathway_Homo sapiens_hsa049170.76098685
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75944813
77Other glycan degradation_Homo sapiens_hsa005110.75782119
78Phenylalanine metabolism_Homo sapiens_hsa003600.75766636
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.73786014
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.73386126
81Inositol phosphate metabolism_Homo sapiens_hsa005620.73250663
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71817752
83Measles_Homo sapiens_hsa051620.71542566
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71329048
85Endometrial cancer_Homo sapiens_hsa052130.71020756
86Complement and coagulation cascades_Homo sapiens_hsa046100.70477792
87Tight junction_Homo sapiens_hsa045300.67727302
88HIF-1 signaling pathway_Homo sapiens_hsa040660.67617351
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.67528645
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66519909
91Apoptosis_Homo sapiens_hsa042100.65471405
92Mineral absorption_Homo sapiens_hsa049780.64156649
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63276587
94Regulation of autophagy_Homo sapiens_hsa041400.62591495
95Pathways in cancer_Homo sapiens_hsa052000.60722106
96MicroRNAs in cancer_Homo sapiens_hsa052060.60093243
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.59803118
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59780703
99Starch and sucrose metabolism_Homo sapiens_hsa005000.59747050
100Influenza A_Homo sapiens_hsa051640.59698834
101Notch signaling pathway_Homo sapiens_hsa043300.59214167
102Colorectal cancer_Homo sapiens_hsa052100.59084197
103Dorso-ventral axis formation_Homo sapiens_hsa043200.59057252
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.57617601
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.56213685
106Lysosome_Homo sapiens_hsa041420.55887245
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55583889
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.54358174
109Insulin signaling pathway_Homo sapiens_hsa049100.53710895
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51312922
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50841576
112ErbB signaling pathway_Homo sapiens_hsa040120.50114880
113Arachidonic acid metabolism_Homo sapiens_hsa005900.49582124
114AMPK signaling pathway_Homo sapiens_hsa041520.49232226
115Glioma_Homo sapiens_hsa052140.47898741
116FoxO signaling pathway_Homo sapiens_hsa040680.47572018
117Rheumatoid arthritis_Homo sapiens_hsa053230.46769940
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46682672
119mTOR signaling pathway_Homo sapiens_hsa041500.46246192
120Glycerolipid metabolism_Homo sapiens_hsa005610.45928380
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44709786
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.44651534
123Herpes simplex infection_Homo sapiens_hsa051680.44567123
124beta-Alanine metabolism_Homo sapiens_hsa004100.44462113
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43802024
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41781827
127Thyroid hormone synthesis_Homo sapiens_hsa049180.40688700

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