LTC4S

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.64810083
2regulation of integrin activation (GO:0033623)5.58462458
3negative regulation of granulocyte differentiation (GO:0030853)5.58016244
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.31194365
5regulation of macrophage chemotaxis (GO:0010758)5.03799971
6production of molecular mediator involved in inflammatory response (GO:0002532)4.57158908
7microglial cell activation (GO:0001774)4.50065646
8mature B cell differentiation involved in immune response (GO:0002313)4.44774688
9phagocytosis, engulfment (GO:0006911)4.38476339
10positive regulation of antigen processing and presentation (GO:0002579)4.33401885
11regulation of mononuclear cell migration (GO:0071675)4.30587029
12positive regulation of monocyte chemotaxis (GO:0090026)4.27211628
13response to peptidoglycan (GO:0032494)4.22280758
14macrophage activation involved in immune response (GO:0002281)4.19828601
15positive regulation of prostaglandin secretion (GO:0032308)4.10113196
16* lipoxygenase pathway (GO:0019372)3.98958446
17cellular response to zinc ion (GO:0071294)3.91445183
18membrane invagination (GO:0010324)3.87683381
19eosinophil chemotaxis (GO:0048245)3.85452768
20granulocyte activation (GO:0036230)3.84799780
21neutrophil activation (GO:0042119)3.84624891
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84153792
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.84153792
24modulation by symbiont of host immune response (GO:0052553)3.84153792
25positive regulation by symbiont of host defense response (GO:0052509)3.84153792
26modulation by symbiont of host defense response (GO:0052031)3.84153792
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84153792
28apoptotic cell clearance (GO:0043277)3.76259819
29germinal center formation (GO:0002467)3.75100813
30positive regulation of T cell chemotaxis (GO:0010820)3.72355124
31regulation of T cell chemotaxis (GO:0010819)3.72355124
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70950852
33regulation of antigen processing and presentation (GO:0002577)3.70035577
34regulation of interferon-beta biosynthetic process (GO:0045357)3.69117213
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68754193
36positive regulation of interferon-alpha production (GO:0032727)3.68155892
37macrophage activation (GO:0042116)3.67744128
38regulation of prostaglandin secretion (GO:0032306)3.67225524
39cellular extravasation (GO:0045123)3.66061911
40positive regulation of protein homooligomerization (GO:0032464)3.65255188
41regulation of germinal center formation (GO:0002634)3.62286119
42negative regulation of interleukin-12 production (GO:0032695)3.53698794
43regulation of mast cell activation (GO:0033003)3.53114516
44respiratory burst (GO:0045730)3.47069567
45positive regulation of cholesterol efflux (GO:0010875)3.44472681
46positive regulation of mast cell degranulation (GO:0043306)3.44126124
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.44126124
48regulation of interferon-alpha production (GO:0032647)3.43441946
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42521450
50positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.42319138
51positive regulation of lymphocyte migration (GO:2000403)3.41996144
52G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.41991393
53regulation of monocyte chemotaxis (GO:0090025)3.41175147
54negative regulation of nitric oxide biosynthetic process (GO:0045019)3.39648110
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39363339
56lymphocyte chemotaxis (GO:0048247)3.38809171
57positive regulation of chemokine secretion (GO:0090197)3.38167537
58eosinophil migration (GO:0072677)3.34784745
59immunoglobulin mediated immune response (GO:0016064)3.34135954
60positive regulation of T cell migration (GO:2000406)3.32714525
61response to muramyl dipeptide (GO:0032495)3.32212588
62regulation of B cell receptor signaling pathway (GO:0050855)3.31448296
63regulation of lymphocyte chemotaxis (GO:1901623)3.31164682
64myeloid cell activation involved in immune response (GO:0002275)3.28857280
65detection of molecule of bacterial origin (GO:0032490)3.27825753
66regulation of apoptotic cell clearance (GO:2000425)3.26640340
67tumor necrosis factor-mediated signaling pathway (GO:0033209)3.24329491
68negative regulation of erythrocyte differentiation (GO:0045647)3.18842018
69regulation of T cell migration (GO:2000404)3.18788545
70regulation of leukocyte degranulation (GO:0043300)3.16151666
71mature B cell differentiation (GO:0002335)3.14366063
72negative regulation of interleukin-6 production (GO:0032715)3.12918810
73B cell mediated immunity (GO:0019724)3.12246679
74regulation of mast cell degranulation (GO:0043304)3.10288345
75positive regulation of mast cell activation (GO:0033005)3.08375627
76positive regulation of cellular amide metabolic process (GO:0034250)3.06019219
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.05093181
78lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04829976
79regulation of T cell tolerance induction (GO:0002664)3.04802639
80positive regulation of natural killer cell differentiation (GO:0032825)3.04015043
81positive regulation of B cell differentiation (GO:0045579)3.03577766
82regulation of cholesterol storage (GO:0010885)3.02716799
83purinergic nucleotide receptor signaling pathway (GO:0035590)3.02258391
84regulation of lymphocyte migration (GO:2000401)3.01156896
85positive regulation of gamma-delta T cell activation (GO:0046645)2.97918017
86hyaluronan catabolic process (GO:0030214)2.97084924
87keratan sulfate catabolic process (GO:0042340)2.96962276
88regulation of tolerance induction (GO:0002643)2.96464767
89regulation of mast cell activation involved in immune response (GO:0033006)2.96067766
90response to protozoan (GO:0001562)2.95982590
91complement activation, alternative pathway (GO:0006957)2.95646220
92adaptation of signaling pathway (GO:0023058)2.92298085
93embryonic process involved in female pregnancy (GO:0060136)2.90883303
94* leukotriene metabolic process (GO:0006691)2.90243679
95negative regulation of cell killing (GO:0031342)2.88648505
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88648505
97positive regulation of cholesterol transport (GO:0032376)2.87544614
98positive regulation of sterol transport (GO:0032373)2.87544614
99myeloid dendritic cell differentiation (GO:0043011)2.87409234
100defense response to protozoan (GO:0042832)2.86098322
101T-helper cell differentiation (GO:0042093)2.84576267
102CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.84576267
103myeloid dendritic cell activation (GO:0001773)2.84420003
104T cell migration (GO:0072678)2.83605041
105positive regulation of defense response to virus by host (GO:0002230)2.83553531
106mannose metabolic process (GO:0006013)2.82823355
107leukocyte degranulation (GO:0043299)2.82546922
108cellular response to thyroid hormone stimulus (GO:0097067)2.82302176
109adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.82048137
110negative regulation of tumor necrosis factor production (GO:0032720)2.81726992
111phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.81538486
112positive regulation of protein oligomerization (GO:0032461)2.80884082
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79776659
114myeloid leukocyte activation (GO:0002274)2.79556627
115negative regulation of cytokine production involved in immune response (GO:0002719)2.77817610
116positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.77092506
117negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.76774138
118positive thymic T cell selection (GO:0045059)2.76181997
119response to lipoprotein particle (GO:0055094)2.76161533
120positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.75904755
121Peyers patch development (GO:0048541)2.75493826
122mucosal-associated lymphoid tissue development (GO:0048537)2.75493826
123regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.75344596
124positive regulation of icosanoid secretion (GO:0032305)2.75308839
125dendritic cell differentiation (GO:0097028)2.74990069
126regulation of hypersensitivity (GO:0002883)2.74063202
127positive regulation of leukocyte degranulation (GO:0043302)2.73797576
128cytokine secretion (GO:0050663)2.73780475
129dendritic cell chemotaxis (GO:0002407)2.72889279
130positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72490027
131negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.70468637
132positive regulation of interferon-beta production (GO:0032728)2.70214790
133regulation of tumor necrosis factor production (GO:0032680)2.70139745
134sleep (GO:0030431)2.68557747
135negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.68386196
136Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67776909
137positive regulation of T cell apoptotic process (GO:0070234)2.67610891
138lymph node development (GO:0048535)2.67348499
139endothelial cell chemotaxis (GO:0035767)2.66510997
140chaperone mediated protein folding requiring cofactor (GO:0051085)2.64912585
141regulation of T-helper 1 cell differentiation (GO:0045625)2.64554572
142mast cell activation (GO:0045576)2.64239327
143hydrogen peroxide biosynthetic process (GO:0050665)2.64108326
144positive regulation of heat generation (GO:0031652)2.62959761
145reactive oxygen species biosynthetic process (GO:1903409)2.62438777
146regulation of inflammatory response to antigenic stimulus (GO:0002861)2.61959694
147production of molecular mediator of immune response (GO:0002440)2.61774733
148positive regulation of interleukin-17 production (GO:0032740)2.61760996
149purine deoxyribonucleotide catabolic process (GO:0009155)2.60338491
150amino sugar catabolic process (GO:0046348)2.59096136
151positive regulation of calcium-mediated signaling (GO:0050850)2.58730210
152pinocytosis (GO:0006907)2.57880057
153regulation of icosanoid secretion (GO:0032303)2.57065602
154regulation of gamma-delta T cell activation (GO:0046643)2.56437388
155negative regulation of lipid storage (GO:0010888)2.55779690
156positive regulation of tumor necrosis factor production (GO:0032760)2.55431587
157regulation of activated T cell proliferation (GO:0046006)2.53513313
158positive regulation of activated T cell proliferation (GO:0042104)2.53304698
159regulation of gamma-delta T cell differentiation (GO:0045586)2.52988607
160regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.51208221
161interferon-gamma-mediated signaling pathway (GO:0060333)2.50096719
162regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.48385496
163positive regulation of T cell differentiation (GO:0045582)2.48381085
164negative regulation of T cell mediated immunity (GO:0002710)2.48214232
165response to thyroid hormone (GO:0097066)2.45837295
166positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.45663805
167positive regulation of interleukin-10 production (GO:0032733)2.45554559
168positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.44540553
169positive regulation of T cell differentiation in thymus (GO:0033089)2.44088070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.02702738
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.84324722
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.72000940
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.10083753
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.93889707
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.64631690
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16191166
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03005105
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96121155
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91280068
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74509733
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58160970
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41568745
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37249916
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36458487
16* VDR_21846776_ChIP-Seq_THP-1_Human2.33597051
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31782660
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26341146
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13345870
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12272212
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06950718
22* SPI1_23547873_ChIP-Seq_NB4_Human2.05984906
23* VDR_24763502_ChIP-Seq_THP-1_Human2.03900071
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03001238
25SCL_19346495_ChIP-Seq_HPC-7_Human2.00563727
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98369596
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97486560
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.92313798
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.90431062
30* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.89455889
31SPI1_23127762_ChIP-Seq_K562_Human1.88396978
32* BCL6_27268052_Chip-Seq_Bcells_Human1.86865074
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85514182
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82820047
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69394630
36* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66334377
37* VDR_24787735_ChIP-Seq_THP-1_Human1.64774565
38MAF_26560356_Chip-Seq_TH1_Human1.64177933
39PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.63338295
40* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62205671
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60925580
42* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58987101
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.55151247
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55093678
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51803133
46RUNX_20019798_ChIP-Seq_JUKART_Human1.51740947
47* BCOR_27268052_Chip-Seq_Bcells_Human1.51506965
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48473756
49* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47847972
50LXR_22292898_ChIP-Seq_THP-1_Human1.47646341
51CTCF_26484167_Chip-Seq_Bcells_Mouse1.45705113
52* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44998991
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44556399
54* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44507243
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44067830
56* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41866919
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41712914
58* PU_27001747_Chip-Seq_BMDM_Mouse1.41382570
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40022506
60* P68_20966046_ChIP-Seq_HELA_Human1.38701953
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.36749992
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35440319
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.33810239
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33769825
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32289571
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31709819
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31636196
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31636196
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31636196
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30518327
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.29612599
72* TCF7_22412390_ChIP-Seq_EML_Mouse1.26980600
73* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26234808
74SPI1_20517297_ChIP-Seq_HL60_Human1.26220599
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22485619
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21248148
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20416369
78* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20226129
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.19793662
80GATA3_26560356_Chip-Seq_TH2_Human1.19776727
81E2F1_20622854_ChIP-Seq_HELA_Human1.19468078
82GATA3_27048872_Chip-Seq_THYMUS_Human1.18725775
83MYB_26560356_Chip-Seq_TH2_Human1.18721342
84* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18551959
85SA1_27219007_Chip-Seq_Bcells_Human1.17750019
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17710444
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17151293
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15970625
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.14352470
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.12427513
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.12132506
92* PHF8_20622854_ChIP-Seq_HELA_Human1.11431683
93* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10762979
94CTCF_20526341_ChIP-Seq_ESCs_Human1.10251709
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.10064287
96P300_27268052_Chip-Seq_Bcells_Human1.09988845
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08951208
98* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08804689
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.08313987
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08128340
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07690480
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07125822
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06631546
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05813966
105STAT1_20625510_ChIP-Seq_HELA_Human1.05719101
106MYB_26560356_Chip-Seq_TH1_Human1.04497785
107* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04467907
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03648862
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03425898
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.98940404
111* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97566786
112* KDM2B_26808549_Chip-Seq_DND41_Human0.97385114
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96803741
114UTX_26944678_Chip-Seq_JUKART_Human0.94574491
115MAF_26560356_Chip-Seq_TH2_Human0.94511828
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94147310
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93377705
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93258190
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92849405
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90463369
121* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90176776
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89665938
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88080007
124EGR1_19032775_ChIP-ChIP_M12_Human0.86486754
125GATA1_19941826_ChIP-Seq_K562_Human0.86067265
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85092749
127MYC_22102868_ChIP-Seq_BL_Human0.84702979
128* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83566255
129GATA2_19941826_ChIP-Seq_K562_Human0.80650443
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.80609563
131CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79727102
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78526742
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.78215306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.67403425
2MP0001835_abnormal_antigen_presentation3.84479616
3MP0003436_decreased_susceptibility_to3.48027434
4* MP0002148_abnormal_hypersensitivity_rea3.47407857
5MP0003191_abnormal_cellular_cholesterol3.35930931
6MP0006082_CNS_inflammation2.86707328
7MP0002419_abnormal_innate_immunity2.77690177
8MP0000685_abnormal_immune_system2.73798206
9MP0003724_increased_susceptibility_to2.66897462
10MP0005000_abnormal_immune_tolerance2.65004916
11MP0009840_abnormal_foam_cell2.58185641
12MP0001790_abnormal_immune_system2.57091713
13MP0005387_immune_system_phenotype2.57091713
14MP0003172_abnormal_lysosome_physiology2.38460779
15MP0005025_abnormal_response_to2.34965387
16MP0004510_myositis2.29910262
17MP0009785_altered_susceptibility_to2.29420509
18MP0005464_abnormal_platelet_physiology2.29346529
19MP0009278_abnormal_bone_marrow2.27093164
20MP0002452_abnormal_antigen_presenting2.24689649
21MP0003075_altered_response_to2.17872505
22MP0001800_abnormal_humoral_immune2.15428615
23MP0002723_abnormal_immune_serum2.05166618
24MP0005670_abnormal_white_adipose2.03172269
25MP0005671_abnormal_response_to2.02186149
26MP0003806_abnormal_nucleotide_metabolis1.98081019
27MP0001819_abnormal_immune_cell1.88996779
28MP0001533_abnormal_skeleton_physiology1.88881740
29MP0002420_abnormal_adaptive_immunity1.88088144
30* MP0002405_respiratory_system_inflammati1.86825034
31MP0002254_reproductive_system_inflammat1.84779605
32MP0002166_altered_tumor_susceptibility1.83564285
33MP0000343_altered_response_to1.74994895
34MP0009333_abnormal_splenocyte_physiolog1.68334665
35MP0003828_pulmonary_edema1.67168556
36MP0005075_abnormal_melanosome_morpholog1.66966522
37MP0010155_abnormal_intestine_physiology1.62062707
38MP0002653_abnormal_ependyma_morphology1.59543216
39MP0002138_abnormal_hepatobiliary_system1.58303190
40MP0005310_abnormal_salivary_gland1.57249387
41MP0003690_abnormal_glial_cell1.55498717
42MP0002009_preneoplasia1.54795400
43MP0001853_heart_inflammation1.54303356
44MP0001845_abnormal_inflammatory_respons1.53864959
45MP0005397_hematopoietic_system_phenotyp1.53447279
46MP0001545_abnormal_hematopoietic_system1.53447279
47MP0002006_tumorigenesis1.52019694
48MP0002998_abnormal_bone_remodeling1.50014397
49MP0003303_peritoneal_inflammation1.49136539
50MP0005503_abnormal_tendon_morphology1.40984169
51MP0005174_abnormal_tail_pigmentation1.40570069
52MP0008469_abnormal_protein_level1.39203436
53MP0000716_abnormal_immune_system1.39172068
54MP0005171_absent_coat_pigmentation1.36184307
55MP0003448_altered_tumor_morphology1.32554035
56MP0002139_abnormal_hepatobiliary_system1.29375799
57MP0000689_abnormal_spleen_morphology1.28203045
58MP0004947_skin_inflammation1.26562317
59MP0002398_abnormal_bone_marrow1.23215965
60MP0003646_muscle_fatigue1.22275733
61MP0004782_abnormal_surfactant_physiolog1.14785028
62MP0000465_gastrointestinal_hemorrhage1.14576827
63MP0009764_decreased_sensitivity_to1.14103788
64MP0003453_abnormal_keratinocyte_physiol1.12628374
65MP0005076_abnormal_cell_differentiation1.11407714
66MP0005084_abnormal_gallbladder_morpholo1.11109784
67MP0002396_abnormal_hematopoietic_system1.11040224
68MP0002429_abnormal_blood_cell1.11000717
69MP0000490_abnormal_crypts_of1.10074412
70MP0003763_abnormal_thymus_physiology1.08348136
71MP0009115_abnormal_fat_cell1.08174163
72MP0002722_abnormal_immune_system1.07831018
73MP0008004_abnormal_stomach_pH1.05703113
74MP0008438_abnormal_cutaneous_collagen1.04152405
75MP0002277_abnormal_respiratory_mucosa1.02715589
76MP0005167_abnormal_blood-brain_barrier1.00377201
77MP0005166_decreased_susceptibility_to1.00049131
78MP0001873_stomach_inflammation0.99147141
79MP0005666_abnormal_adipose_tissue0.98551439
80MP0005390_skeleton_phenotype0.97586213
81MP0000015_abnormal_ear_pigmentation0.96748716
82MP0010368_abnormal_lymphatic_system0.95774774
83MP0001663_abnormal_digestive_system0.94487166
84MP0004185_abnormal_adipocyte_glucose0.92325827
85MP0001915_intracranial_hemorrhage0.90428107
86* MP0000249_abnormal_blood_vessel0.89461334
87MP0003879_abnormal_hair_cell0.88656123
88MP0001501_abnormal_sleep_pattern0.87246104
89MP0003656_abnormal_erythrocyte_physiolo0.87226868
90MP0005379_endocrine/exocrine_gland_phen0.86061217
91MP0004883_abnormal_blood_vessel0.85328079
92MP0005377_hearing/vestibular/ear_phenot0.85235669
93MP0003878_abnormal_ear_physiology0.85235669
94MP0003279_aneurysm0.85224690
95MP0002971_abnormal_brown_adipose0.84898663
96MP0005164_abnormal_response_to0.84048947
97MP0004130_abnormal_muscle_cell0.83343232
98MP0001348_abnormal_lacrimal_gland0.83331060
99MP0004019_abnormal_vitamin_homeostasis0.82188723
100MP0000372_irregular_coat_pigmentation0.82057013
101MP0003566_abnormal_cell_adhesion0.81983762
102MP0000858_altered_metastatic_potential0.81946139
103MP0009765_abnormal_xenobiotic_induced0.81179586
104MP0000371_diluted_coat_color0.80156544
105MP0005646_abnormal_pituitary_gland0.79808149
106MP0009763_increased_sensitivity_to0.79693775
107MP0000604_amyloidosis0.79662292
108MP0008057_abnormal_DNA_replication0.79193544
109MP0003045_fibrosis0.75428510
110MP0005334_abnormal_fat_pad0.75104449
111MP0002933_joint_inflammation0.73462761
112MP0000609_abnormal_liver_physiology0.72107165
113MP0005165_increased_susceptibility_to0.71388770
114MP0003300_gastrointestinal_ulcer0.71374458
115MP0000703_abnormal_thymus_morphology0.70069000
116MP0003195_calcinosis0.69870965
117MP0003186_abnormal_redox_activity0.69055703
118MP0009379_abnormal_foot_pigmentation0.68748941
119MP0004742_abnormal_vestibular_system0.68323420
120MP0000681_abnormal_thyroid_gland0.67459706
121MP0001542_abnormal_bone_strength0.66812168
122MP0003638_abnormal_response/metabolism_0.66554256
123MP0005410_abnormal_fertilization0.66337633
124MP0005319_abnormal_enzyme/_coenzyme0.66168572
125MP0002132_abnormal_respiratory_system0.65849888
126MP0001851_eye_inflammation0.64785088
127MP0003705_abnormal_hypodermis_morpholog0.64781981
128MP0003866_abnormal_defecation0.64518843
129MP0004808_abnormal_hematopoietic_stem0.64418607
130MP0009384_cardiac_valve_regurgitation0.64328576
131MP0002735_abnormal_chemical_nociception0.63848931
132MP0000767_abnormal_smooth_muscle0.63050623
133MP0003795_abnormal_bone_structure0.62479816
134MP0005647_abnormal_sex_gland0.59997692
135MP0005083_abnormal_biliary_tract0.59732503

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)9.19401024
2Glomerulonephritis (HP:0000099)6.72360018
3Recurrent abscess formation (HP:0002722)6.13153547
4Dysostosis multiplex (HP:0000943)5.80247237
5Complement deficiency (HP:0004431)5.46341207
6Recurrent bacterial skin infections (HP:0005406)5.42556566
7Pustule (HP:0200039)5.38387007
8Abnormality of complement system (HP:0005339)5.29392068
9Eczematoid dermatitis (HP:0000976)4.83178897
10Vacuolated lymphocytes (HP:0001922)4.68407516
11Recurrent gram-negative bacterial infections (HP:0005420)4.36467640
12Mucopolysacchariduria (HP:0008155)4.34362452
13Urinary glycosaminoglycan excretion (HP:0003541)4.34362452
14Axonal loss (HP:0003447)4.26772750
15Nephritis (HP:0000123)4.22627584
16Stomatitis (HP:0010280)4.02863642
17Abnormality of polysaccharide metabolism (HP:0011012)4.02765427
18Abnormality of glycosaminoglycan metabolism (HP:0004371)4.02765427
19Abnormality of mucopolysaccharide metabolism (HP:0011020)4.02765427
20Increased IgM level (HP:0003496)3.86623695
21Abnormality of macrophages (HP:0004311)3.57172683
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.55382318
23Increased cerebral lipofuscin (HP:0011813)3.43560965
24Thick nail (HP:0001805)3.30580056
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.20342584
26Myositis (HP:0100614)3.19636401
27Abnormality of glycolipid metabolism (HP:0010969)3.14379893
28Abnormality of liposaccharide metabolism (HP:0010968)3.14379893
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.14379893
30Recurrent fungal infections (HP:0002841)3.14045269
31Decreased electroretinogram (ERG) amplitude (HP:0000654)3.11941192
32Cerebral aneurysm (HP:0004944)3.07565399
33Asymmetric septal hypertrophy (HP:0001670)3.05793781
34Orchitis (HP:0100796)3.04728548
35Disinhibition (HP:0000734)3.01723499
36Recurrent skin infections (HP:0001581)3.01263705
37Mediastinal lymphadenopathy (HP:0100721)2.96521384
38Autoimmune thrombocytopenia (HP:0001973)2.95610178
39Gingivitis (HP:0000230)2.91380571
40Increased serum ferritin (HP:0003281)2.86889558
41Keratoconjunctivitis sicca (HP:0001097)2.84955798
42Amyloidosis (HP:0011034)2.80605902
43Keratoconjunctivitis (HP:0001096)2.77588425
44Agnosia (HP:0010524)2.77257878
45Colitis (HP:0002583)2.76214961
46Elevated erythrocyte sedimentation rate (HP:0003565)2.73587084
47Spontaneous hematomas (HP:0007420)2.70674619
48Myocardial infarction (HP:0001658)2.69750634
49Joint stiffness (HP:0001387)2.69142364
50Mutism (HP:0002300)2.66733832
51IgG deficiency (HP:0004315)2.58535813
52Prolonged bleeding time (HP:0003010)2.54240053
53Hematochezia (HP:0002573)2.51486231
54Periodontitis (HP:0000704)2.48671091
55Optic neuritis (HP:0100653)2.44988667
56Retrobulbar optic neuritis (HP:0100654)2.44988667
57Eosinophilia (HP:0001880)2.42619669
58Upper motor neuron abnormality (HP:0002127)2.39430282
59Abolished electroretinogram (ERG) (HP:0000550)2.39041211
60Abnormality of iron homeostasis (HP:0011031)2.39002728
61Prostate neoplasm (HP:0100787)2.38610195
62Chronic obstructive pulmonary disease (HP:0006510)2.38302512
63Obstructive lung disease (HP:0006536)2.38302512
64Rectovaginal fistula (HP:0000143)2.36289476
65Rectal fistula (HP:0100590)2.36289476
66Recurrent viral infections (HP:0004429)2.35571210
67Cellulitis (HP:0100658)2.34892031
68Purpura (HP:0000979)2.34345054
69Progressive neurologic deterioration (HP:0002344)2.31315703
70Petechiae (HP:0000967)2.31049266
71Abnormality of the prostate (HP:0008775)2.30166405
72Abnormality of transition element cation homeostasis (HP:0011030)2.27507067
73Beaking of vertebral bodies (HP:0004568)2.24991708
74Inflammation of the large intestine (HP:0002037)2.24270090
75Leukocytosis (HP:0001974)2.23595691
76Severe combined immunodeficiency (HP:0004430)2.23369214
77Vertigo (HP:0002321)2.22747734
78Intestinal fistula (HP:0100819)2.21576772
79Combined immunodeficiency (HP:0005387)2.20394125
80Chronic mucocutaneous candidiasis (HP:0002728)2.19028498
81Recurrent cutaneous fungal infections (HP:0011370)2.19028498
82Hemoptysis (HP:0002105)2.16726160
83Osteolytic defects of the hand bones (HP:0009699)2.16455995
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.16455995
85Abnormality of T cell number (HP:0011839)2.15593913
86T lymphocytopenia (HP:0005403)2.15432831
87Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15426141
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11254220
89Hypergammaglobulinemia (HP:0010702)2.10961074
90Vaginal fistula (HP:0004320)2.10329685
91Pathologic fracture (HP:0002756)2.08981693
92Spondylolisthesis (HP:0003302)2.08871382
93Encephalitis (HP:0002383)2.08871008
94Abnormality of the pleura (HP:0002103)2.08645915
95Decreased central vision (HP:0007663)2.05989545
96Abnormality of T cells (HP:0002843)2.05897410
97Arterial thrombosis (HP:0004420)2.05430938
98Gastrointestinal infarctions (HP:0005244)2.05360972
99Pulmonary fibrosis (HP:0002206)2.02509297
100Attenuation of retinal blood vessels (HP:0007843)2.02145891
101Albinism (HP:0001022)2.01466691
102Abnormality of male internal genitalia (HP:0000022)1.99559386
103Abnormal delayed hypersensitivity skin test (HP:0002963)1.99458452
104Loss of speech (HP:0002371)1.99301150
105Chest pain (HP:0100749)1.99294340
106Panhypogammaglobulinemia (HP:0003139)1.98988813
107Granulocytopenia (HP:0001913)1.98306375
108Gastrointestinal inflammation (HP:0004386)1.96775448
109Coarse hair (HP:0002208)1.96396267
110Peripheral demyelination (HP:0011096)1.95981424
111Hypertensive crisis (HP:0100735)1.94413633
112Basal ganglia calcification (HP:0002135)1.93050980
113Chronic otitis media (HP:0000389)1.92828758
114Neurofibrillary tangles (HP:0002185)1.92548806
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89985165
116Epistaxis (HP:0000421)1.89145058
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88753665
118Arthralgia (HP:0002829)1.88594335
119Meningitis (HP:0001287)1.88397567
120Arterial tortuosity (HP:0005116)1.88313752
121Progressive visual loss (HP:0000529)1.88265441
122Anhidrosis (HP:0000970)1.88132265
123Pulmonary infiltrates (HP:0002113)1.86791867
124Nasal polyposis (HP:0100582)1.86147433
125Recurrent sinusitis (HP:0011108)1.85883698
126Pulmonary embolism (HP:0002204)1.85146523
127Hepatosplenomegaly (HP:0001433)1.85096498
128Abnormality of eosinophils (HP:0001879)1.84990627
129Spinal muscular atrophy (HP:0007269)1.84859475
130Urethral obstruction (HP:0000796)1.84619482
131Abnormality of T cell physiology (HP:0011840)1.84306900
132J-shaped sella turcica (HP:0002680)1.83941864
133Abnormality of the peritoneum (HP:0002585)1.83665431
134Gangrene (HP:0100758)1.83314363
135Clumsiness (HP:0002312)1.82757242
136Tongue fasciculations (HP:0001308)1.81310812
137Vasculitis (HP:0002633)1.80438884
138Urticaria (HP:0001025)1.80345327
139IgA deficiency (HP:0002720)1.80279887
140Recurrent lower respiratory tract infections (HP:0002783)1.80146456
141Abnormality of the nasal mucosa (HP:0000433)1.79284840
142Orthostatic hypotension (HP:0001278)1.79012694
143Retinal atrophy (HP:0001105)1.77872871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.61276357
2TGFBR24.30203872
3BCKDK3.23926599
4MAPK153.22853155
5NME23.22114653
6IRAK43.01175717
7MAP3K142.73290723
8GRK72.62590762
9IRAK32.60999640
10TYK22.58257265
11MAP4K12.30140714
12PIM22.26535957
13TBK12.23022729
14MAP3K62.22794388
15MATK2.19707153
16GRK62.16858060
17FGR2.16059369
18CSF1R2.07067391
19IKBKB2.02881580
20CSK2.02742771
21CAMK1D1.94873190
22BMX1.90153556
23MAP3K111.84775921
24ICK1.79966035
25NEK91.76774727
26TNK21.69146596
27ERN11.68500637
28KDR1.68217255
29TLK11.67858002
30STK101.58664037
31TIE11.56775333
32RIPK41.56041979
33MST1R1.52090015
34TESK21.35174354
35MOS1.30807684
36MAP4K21.29189942
37MAP3K131.26373592
38YES11.24693887
39CDK61.23470162
40MAP3K101.22884719
41TAOK21.21725425
42DDR21.20986025
43DAPK11.19589057
44KIT1.19297807
45PIM11.17304463
46JAK21.14726389
47BTK1.12677911
48JAK11.12104724
49TEC1.11622621
50LYN1.10889115
51JAK31.09464052
52IKBKE1.09212181
53CHUK1.06773950
54RPS6KC11.06124551
55RPS6KL11.06124551
56ZAK1.05587374
57TRPM71.04485024
58RPS6KA61.03841492
59CAMK1G0.98718255
60TAOK30.98160644
61EPHB10.97274169
62VRK20.96348444
63TAOK10.93501199
64PDK20.89298460
65TRIB30.88579063
66HCK0.88168957
67CLK10.87570667
68SYK0.86881806
69LCK0.86649176
70MUSK0.86110941
71MARK30.85721857
72MAPKAPK30.82760950
73BMPR20.79244307
74TXK0.77816607
75MAPKAPK20.77601785
76DYRK1B0.75150898
77MET0.74545383
78MAPK110.73807787
79PINK10.72906514
80PIK3CG0.72756633
81ZAP700.69956906
82PRKCQ0.67569663
83GSK3A0.65822656
84IRAK20.65737010
85EIF2AK20.65001169
86FLT30.64866176
87ADRBK20.64756807
88CDK40.63597347
89PRKAA20.61744570
90MAPK120.60874473
91TGFBR10.58621350
92PAK40.57819979
93EGFR0.57625411
94PKN10.57515988
95PRKD20.56980684
96GRK50.56977794
97PRKCD0.54677786
98MAPK40.53986464
99PTK60.50964817
100RAF10.50734919
101GRK10.50668055
102CAMKK20.47994438
103PRPF4B0.44994148
104MAP3K30.43035521
105MAPKAPK50.42933768
106FES0.42409329
107IRAK10.41715560
108MAP2K60.40944212
109MAP3K10.37736341
110ARAF0.37187688
111ABL20.36845143
112ABL10.36475700
113TESK10.35235585
114MAP2K30.34614154
115ADRBK10.33761699
116IGF1R0.33582388
117TRIM280.33507496
118RPS6KA10.32984954
119STK30.32708666
120INSR0.31725154
121STK160.31671415
122DAPK20.30246379
123MAPK70.29801589
124BMPR1B0.29544519
125MAP2K20.29060153
126HIPK20.29055155
127DAPK30.28898137
128RPS6KA50.27604384
129RIPK10.26663168
130ITK0.26620565
131CDK90.26217336
132MAPK30.25209071
133CAMKK10.22669804
134RPS6KA20.22104043
135PDK10.21794671

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.74572930
2Other glycan degradation_Homo sapiens_hsa005113.84671108
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.58605846
4Lysosome_Homo sapiens_hsa041422.78862423
5Leishmaniasis_Homo sapiens_hsa051402.69856195
6Pertussis_Homo sapiens_hsa051332.63300334
7Osteoclast differentiation_Homo sapiens_hsa043802.20012795
8Legionellosis_Homo sapiens_hsa051342.11795904
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04165224
10Complement and coagulation cascades_Homo sapiens_hsa046101.94921672
11Tuberculosis_Homo sapiens_hsa051521.80370707
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.79443734
13Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75765939
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.71043678
15B cell receptor signaling pathway_Homo sapiens_hsa046621.69630239
16Allograft rejection_Homo sapiens_hsa053301.67543110
17Measles_Homo sapiens_hsa051621.66769421
18Graft-versus-host disease_Homo sapiens_hsa053321.63217260
19Malaria_Homo sapiens_hsa051441.61630312
20Chemokine signaling pathway_Homo sapiens_hsa040621.52615609
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48934785
22Prion diseases_Homo sapiens_hsa050201.47464558
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45078718
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44731967
25Toxoplasmosis_Homo sapiens_hsa051451.43941945
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40660959
27Salmonella infection_Homo sapiens_hsa051321.39205900
28Fatty acid biosynthesis_Homo sapiens_hsa000611.35530418
29Phagosome_Homo sapiens_hsa041451.33556309
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32152555
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30468759
32Shigellosis_Homo sapiens_hsa051311.28201200
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27757888
34* Arachidonic acid metabolism_Homo sapiens_hsa005901.24500023
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23262648
36Rheumatoid arthritis_Homo sapiens_hsa053231.20793913
37Primary immunodeficiency_Homo sapiens_hsa053401.17445167
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.16976318
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16533360
40Apoptosis_Homo sapiens_hsa042101.15779303
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15080720
42Hematopoietic cell lineage_Homo sapiens_hsa046401.14211382
43Antigen processing and presentation_Homo sapiens_hsa046121.11050604
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10607179
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08590229
46Influenza A_Homo sapiens_hsa051641.08177268
47Acute myeloid leukemia_Homo sapiens_hsa052211.02781553
48Autoimmune thyroid disease_Homo sapiens_hsa053201.01193133
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00205703
50Herpes simplex infection_Homo sapiens_hsa051681.00163321
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97841601
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95861610
53Linoleic acid metabolism_Homo sapiens_hsa005910.94762078
54Viral myocarditis_Homo sapiens_hsa054160.93842905
55TNF signaling pathway_Homo sapiens_hsa046680.91629493
56Histidine metabolism_Homo sapiens_hsa003400.90735628
57Platelet activation_Homo sapiens_hsa046110.88700995
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86303180
59Peroxisome_Homo sapiens_hsa041460.84947058
60Sulfur metabolism_Homo sapiens_hsa009200.84921076
61Tryptophan metabolism_Homo sapiens_hsa003800.84165476
62Phototransduction_Homo sapiens_hsa047440.82140358
63African trypanosomiasis_Homo sapiens_hsa051430.80685618
64Asthma_Homo sapiens_hsa053100.80429754
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79550622
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.78961768
67Notch signaling pathway_Homo sapiens_hsa043300.76726375
68Hepatitis B_Homo sapiens_hsa051610.76660363
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76296405
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74568434
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73670024
72Base excision repair_Homo sapiens_hsa034100.73276593
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73105898
74Chronic myeloid leukemia_Homo sapiens_hsa052200.73029149
75Amoebiasis_Homo sapiens_hsa051460.71091864
76Systemic lupus erythematosus_Homo sapiens_hsa053220.69498134
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65691706
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63293508
79Pancreatic cancer_Homo sapiens_hsa052120.63071893
80Collecting duct acid secretion_Homo sapiens_hsa049660.61475840
81Adherens junction_Homo sapiens_hsa045200.57671939
82Type I diabetes mellitus_Homo sapiens_hsa049400.55404667
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54749642
84Small cell lung cancer_Homo sapiens_hsa052220.54423393
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54182554
86Ether lipid metabolism_Homo sapiens_hsa005650.52429856
87Endocytosis_Homo sapiens_hsa041440.52226635
88ABC transporters_Homo sapiens_hsa020100.51919159
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51459101
90T cell receptor signaling pathway_Homo sapiens_hsa046600.49592125
91Chemical carcinogenesis_Homo sapiens_hsa052040.49544383
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48747551
93Renin-angiotensin system_Homo sapiens_hsa046140.46137822
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45053520
95Hepatitis C_Homo sapiens_hsa051600.44555457
96VEGF signaling pathway_Homo sapiens_hsa043700.44041549
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.43911292
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.43474280
99Caffeine metabolism_Homo sapiens_hsa002320.43003734
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.42799326
101Oxidative phosphorylation_Homo sapiens_hsa001900.40557656
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39187180
103Ribosome_Homo sapiens_hsa030100.38499791
104Olfactory transduction_Homo sapiens_hsa047400.37333680
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36152611
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.34660108
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34259818
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.34053237
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33842596
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33612682
111Homologous recombination_Homo sapiens_hsa034400.31785232
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.31520337
113HIF-1 signaling pathway_Homo sapiens_hsa040660.31058900
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30443358
115Sphingolipid metabolism_Homo sapiens_hsa006000.29727285
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29234398
117Retinol metabolism_Homo sapiens_hsa008300.28830006
118Colorectal cancer_Homo sapiens_hsa052100.28257756
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28084141
120p53 signaling pathway_Homo sapiens_hsa041150.27509387
121Proteoglycans in cancer_Homo sapiens_hsa052050.25764519
122mTOR signaling pathway_Homo sapiens_hsa041500.24488286
123PPAR signaling pathway_Homo sapiens_hsa033200.24397826
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.24303494
125Epstein-Barr virus infection_Homo sapiens_hsa051690.23812086
126Mineral absorption_Homo sapiens_hsa049780.23591567
127Pathways in cancer_Homo sapiens_hsa052000.22332541
128Vitamin digestion and absorption_Homo sapiens_hsa049770.21962669
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21332887
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20975043
131MAPK signaling pathway_Homo sapiens_hsa040100.20777981
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.20654216
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20566568
134Glutathione metabolism_Homo sapiens_hsa004800.20399402

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