LSR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.79022032
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.94839488
3L-phenylalanine catabolic process (GO:0006559)6.94839488
4L-phenylalanine metabolic process (GO:0006558)6.80111857
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80111857
6hemidesmosome assembly (GO:0031581)6.18183561
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.17644990
8aromatic amino acid family catabolic process (GO:0009074)6.07754044
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.74468358
10tryptophan catabolic process (GO:0006569)5.36617534
11indole-containing compound catabolic process (GO:0042436)5.36617534
12indolalkylamine catabolic process (GO:0046218)5.36617534
13kynurenine metabolic process (GO:0070189)5.33042258
14sulfur amino acid catabolic process (GO:0000098)5.30090391
15urea cycle (GO:0000050)5.29414083
16urea metabolic process (GO:0019627)5.29414083
17cysteine metabolic process (GO:0006534)5.26511585
18high-density lipoprotein particle remodeling (GO:0034375)5.21410468
19bile acid biosynthetic process (GO:0006699)5.15940233
20negative regulation of fibrinolysis (GO:0051918)5.14087716
21tryptophan metabolic process (GO:0006568)5.12105705
22glyoxylate metabolic process (GO:0046487)5.07577832
23peptidyl-glutamic acid carboxylation (GO:0017187)4.94687215
24protein carboxylation (GO:0018214)4.94687215
25alpha-linolenic acid metabolic process (GO:0036109)4.93762002
26regulation of fibrinolysis (GO:0051917)4.93677574
27proline biosynthetic process (GO:0006561)4.90610841
28regulation of protein activation cascade (GO:2000257)4.86837569
29complement activation, alternative pathway (GO:0006957)4.85816196
30nitrogen cycle metabolic process (GO:0071941)4.84184766
31serine family amino acid catabolic process (GO:0009071)4.79773593
32reverse cholesterol transport (GO:0043691)4.77446701
33homocysteine metabolic process (GO:0050667)4.71179989
34bile acid metabolic process (GO:0008206)4.63332841
35regulation of cholesterol esterification (GO:0010872)4.59769072
36regulation of complement activation (GO:0030449)4.54683770
37regulation of triglyceride catabolic process (GO:0010896)4.52470162
38aromatic amino acid family metabolic process (GO:0009072)4.49299802
39phospholipid efflux (GO:0033700)4.48906509
40triglyceride homeostasis (GO:0070328)4.45995913
41acylglycerol homeostasis (GO:0055090)4.45995913
42negative regulation of cholesterol transport (GO:0032375)4.44910236
43negative regulation of sterol transport (GO:0032372)4.44910236
44protein-lipid complex remodeling (GO:0034368)4.44460675
45macromolecular complex remodeling (GO:0034367)4.44460675
46plasma lipoprotein particle remodeling (GO:0034369)4.44460675
47bile acid and bile salt transport (GO:0015721)4.43156059
48regulation of water loss via skin (GO:0033561)4.41071428
49glycine metabolic process (GO:0006544)4.32083479
50amino-acid betaine metabolic process (GO:0006577)4.27812749
51proline metabolic process (GO:0006560)4.27400408
52tyrosine metabolic process (GO:0006570)4.20883095
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.15732998
54lysine metabolic process (GO:0006553)4.14260424
55lysine catabolic process (GO:0006554)4.14260424
56alpha-amino acid catabolic process (GO:1901606)4.12037841
57regulation of cholesterol homeostasis (GO:2000188)4.08027362
58intestinal cholesterol absorption (GO:0030299)4.04188332
59Golgi transport vesicle coating (GO:0048200)4.04104088
60COPI coating of Golgi vesicle (GO:0048205)4.04104088
61imidazole-containing compound metabolic process (GO:0052803)4.03884282
62serine family amino acid metabolic process (GO:0009069)4.03365675
63activation of Rac GTPase activity (GO:0032863)3.99221749
64plasma lipoprotein particle clearance (GO:0034381)3.96859811
65epithelial cell-cell adhesion (GO:0090136)3.94418951
66cholesterol efflux (GO:0033344)3.92864769
67ethanol oxidation (GO:0006069)3.86665138
68cellular glucuronidation (GO:0052695)3.85038089
69plasma lipoprotein particle assembly (GO:0034377)3.84841036
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.83439210
71cellular amino acid catabolic process (GO:0009063)3.82524397
72drug catabolic process (GO:0042737)3.81009215
73planar cell polarity pathway involved in neural tube closure (GO:0090179)3.80303740
74indolalkylamine metabolic process (GO:0006586)3.80167753
75benzene-containing compound metabolic process (GO:0042537)3.80104169
76fibrinolysis (GO:0042730)3.79812006
77cellular modified amino acid catabolic process (GO:0042219)3.79644710
78response to nitrosative stress (GO:0051409)3.79549354
79gap junction assembly (GO:0016264)3.79068104
80regulation of cholesterol biosynthetic process (GO:0045540)3.77721109
81regulation of bile acid biosynthetic process (GO:0070857)3.77067191
82establishment of skin barrier (GO:0061436)3.75482778
83positive regulation of Cdc42 GTPase activity (GO:0043089)3.74392581
84serine family amino acid biosynthetic process (GO:0009070)3.74197890
85glutamate metabolic process (GO:0006536)3.72425365
86positive regulation of lipoprotein lipase activity (GO:0051006)3.71451405
87positive regulation of triglyceride lipase activity (GO:0061365)3.71451405
88multicellular organismal water homeostasis (GO:0050891)3.68069237
89cholesterol homeostasis (GO:0042632)3.67770056
90cellular ketone body metabolic process (GO:0046950)3.66255248
91lipoprotein metabolic process (GO:0042157)3.65885076
92cellular biogenic amine catabolic process (GO:0042402)3.64720486
93amine catabolic process (GO:0009310)3.64720486
94establishment of apical/basal cell polarity (GO:0035089)3.64100925
95sterol homeostasis (GO:0055092)3.62888188
96negative regulation of lipase activity (GO:0060192)3.60891608
97complement activation, classical pathway (GO:0006958)3.55518269
98phospholipid homeostasis (GO:0055091)3.54364643
99arginine metabolic process (GO:0006525)3.53255760
100very-low-density lipoprotein particle assembly (GO:0034379)3.51564315
101aldehyde catabolic process (GO:0046185)3.51441194
102low-density lipoprotein particle remodeling (GO:0034374)3.47964844
103branching involved in mammary gland duct morphogenesis (GO:0060444)3.47758070
104coenzyme catabolic process (GO:0009109)3.45523119
105ethanol metabolic process (GO:0006067)3.45047507
106complement activation (GO:0006956)3.44426598
107cell-substrate junction assembly (GO:0007044)3.44198848
108flavonoid metabolic process (GO:0009812)3.43561685
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42686412
110glucuronate metabolic process (GO:0019585)3.41963299
111uronic acid metabolic process (GO:0006063)3.41963299
112protein retention in ER lumen (GO:0006621)3.41269607
113regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41018372
114protein-lipid complex assembly (GO:0065005)3.40802799
115primary alcohol catabolic process (GO:0034310)3.39665178
116drug transmembrane transport (GO:0006855)3.39174718
117protein activation cascade (GO:0072376)3.38920288
118plasma lipoprotein particle organization (GO:0071827)3.38700541
119acute-phase response (GO:0006953)3.38601584
120intestinal absorption (GO:0050892)3.37683947
121organic acid catabolic process (GO:0016054)3.34998141
122carboxylic acid catabolic process (GO:0046395)3.34998141
123apoptotic process involved in morphogenesis (GO:0060561)3.34203359
124negative regulation of cell fate specification (GO:0009996)3.33572110
125blood coagulation, intrinsic pathway (GO:0007597)3.32031318
126regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.26501151
127glutamine family amino acid biosynthetic process (GO:0009084)3.16616529
128positive regulation of epidermal cell differentiation (GO:0045606)3.14195851
129GDP-mannose metabolic process (GO:0019673)3.11318183
130glucose 6-phosphate metabolic process (GO:0051156)3.10866040
131protein autoprocessing (GO:0016540)3.10801275
132NADH metabolic process (GO:0006734)3.08306496
133regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.05845873
134negative regulation of keratinocyte proliferation (GO:0010839)3.03713962
135regulation of cholesterol metabolic process (GO:0090181)3.02951615
136atrioventricular valve morphogenesis (GO:0003181)3.01003987
137tight junction assembly (GO:0070830)3.00046533
138adherens junction assembly (GO:0034333)2.99073660
139focal adhesion assembly (GO:0048041)2.96288602
140cell-substrate adherens junction assembly (GO:0007045)2.96288602
141L-alpha-amino acid transmembrane transport (GO:1902475)2.87521169
142water homeostasis (GO:0030104)2.87310314
143semaphorin-plexin signaling pathway (GO:0071526)2.85979789
144regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85097718
145regulation of cardioblast differentiation (GO:0051890)2.84098155
146regulation of glucose import in response to insulin stimulus (GO:2001273)2.83069228
147maternal placenta development (GO:0001893)2.82509717
148peptidyl-tyrosine autophosphorylation (GO:0038083)2.81356831
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.81180697
150intestinal epithelial cell development (GO:0060576)2.79816603
151retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78920967
152negative regulation of viral release from host cell (GO:1902187)2.71958241
153heterochromatin organization (GO:0070828)2.68537295
154glucose catabolic process (GO:0006007)2.68326445
155trophectodermal cell differentiation (GO:0001829)2.67606019
156branching involved in salivary gland morphogenesis (GO:0060445)2.66861569
157amyloid precursor protein catabolic process (GO:0042987)2.63399647
158surfactant homeostasis (GO:0043129)2.63308024
159establishment or maintenance of monopolar cell polarity (GO:0061339)2.62037503
160establishment of monopolar cell polarity (GO:0061162)2.62037503
161regulation of viral release from host cell (GO:1902186)2.58814909
162regulation of translational fidelity (GO:0006450)2.58087486
163positive regulation of epidermis development (GO:0045684)2.57087471
164regulation of mammary gland epithelial cell proliferation (GO:0033599)2.56973183
165epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56586114
166positive regulation of keratinocyte differentiation (GO:0045618)2.56149316
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55573869
168amyloid precursor protein metabolic process (GO:0042982)2.54291244
169regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.53911807
170L-serine metabolic process (GO:0006563)2.51433476
171keratinocyte proliferation (GO:0043616)2.50700618
172cell-cell junction assembly (GO:0007043)2.48206580
173convergent extension (GO:0060026)2.48054596
1744-hydroxyproline metabolic process (GO:0019471)2.46592723
175cell differentiation involved in embryonic placenta development (GO:0060706)2.46505992
176lung epithelium development (GO:0060428)2.44981420
177protein complex localization (GO:0031503)2.44726630
178receptor catabolic process (GO:0032801)2.43265037
179ear development (GO:0043583)2.42802462
180response to food (GO:0032094)2.41831773
181negative regulation of cell size (GO:0045792)2.40466948
182establishment or maintenance of bipolar cell polarity (GO:0061245)2.40068844
183establishment or maintenance of apical/basal cell polarity (GO:0035088)2.40068844
184nucleotide-sugar biosynthetic process (GO:0009226)2.39927590
185basement membrane organization (GO:0071711)2.39778180
186cell-cell junction maintenance (GO:0045217)2.38231825
187epoxygenase P450 pathway (GO:0019373)2.38023668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.24245586
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.53008206
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.72302535
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.63885686
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.55066894
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.46558067
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30676823
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.98112610
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45832651
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.38883034
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.43604453
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31800834
13CLOCK_20551151_ChIP-Seq_293T_Human2.13761284
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2680395
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96524820
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.89347769
17SOX2_27498859_Chip-Seq_STOMACH_Mouse1.89304553
18E2F7_22180533_ChIP-Seq_HELA_Human1.87934080
19MYC_22102868_ChIP-Seq_BL_Human1.84232129
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82593700
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.78328189
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77947782
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74146870
24ZNF263_19887448_ChIP-Seq_K562_Human1.70262728
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61759682
26* GATA4_25053715_ChIP-Seq_YYC3_Human1.61535373
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60398891
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.57449138
29VDR_21846776_ChIP-Seq_THP-1_Human1.55097320
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.53635439
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52948835
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47955518
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.47599972
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.46217637
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45163926
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44585197
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44419804
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41870197
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41760928
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.41327092
41GATA1_22025678_ChIP-Seq_K562_Human1.41030376
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40447818
43* MYC_18555785_ChIP-Seq_MESCs_Mouse1.40425292
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38947505
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.37693265
46P68_20966046_ChIP-Seq_HELA_Human1.37163534
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36870277
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36088412
49HNF4A_19822575_ChIP-Seq_HepG2_Human1.35738626
50GATA6_25053715_ChIP-Seq_YYC3_Human1.34276900
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.27066482
52KDM2B_26808549_Chip-Seq_K562_Human1.25156429
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24613401
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20325769
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19532922
56SMC4_20622854_ChIP-Seq_HELA_Human1.19305543
57* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17732138
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15518545
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14298768
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13947344
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13648274
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12900812
63* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12456236
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10351851
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10279681
66* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09980195
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09559067
68KDM2B_26808549_Chip-Seq_DND41_Human1.09027111
69XRN2_22483619_ChIP-Seq_HELA_Human1.07695392
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06000187
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05890028
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.04943558
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.04598266
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04221567
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03501221
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02993569
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01582960
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01534908
79KLF5_25053715_ChIP-Seq_YYC3_Human1.01291209
80RACK7_27058665_Chip-Seq_MCF-7_Human1.00836132
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00240615
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99683642
83* SOX2_20726797_ChIP-Seq_SW620_Human0.99484375
84NCOR1_26117541_ChIP-Seq_K562_Human0.98252959
85TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98080952
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97597271
87TP53_22127205_ChIP-Seq_IMR90_Human0.97308527
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96934644
89TP63_22573176_ChIP-Seq_HFKS_Human0.96604465
90ATF3_27146783_Chip-Seq_COLON_Human0.94865307
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91471606
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90247943
93* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89043755
94LXR_22292898_ChIP-Seq_THP-1_Human0.87717063
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87418626
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.86534425
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86429921
98HTT_18923047_ChIP-ChIP_STHdh_Human0.85829850
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84959078
100P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84899477
101AR_21909140_ChIP-Seq_LNCAP_Human0.84399355
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83347760
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82569593
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81451645
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80603638
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80150439
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80113414
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.79215527
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78107373
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77985255
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77717458
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76209499
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73060196
114RARB_24833708_ChIP-Seq_LIVER_Mouse0.72570779
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71985077
116* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70350782
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70212715
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69934418
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69559573
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69464077
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69283103
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65366099
123* FOXA1_25552417_ChIP-Seq_VCAP_Human0.64318841
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63799132
125CREB1_26743006_Chip-Seq_LNCaP_Human0.63735251
126* RUNX1_27514584_Chip-Seq_MCF-7_Human0.63356531
127TRIM28_21343339_ChIP-Seq_HEK293_Human0.63346741
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62874617
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62745893
130CEBPB_22108803_ChIP-Seq_LS180_Human0.61641549
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.61495946
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.61192299
133CHD1_26751641_Chip-Seq_LNCaP_Human0.60088921
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.58542864
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.58542864
136KAP1_22055183_ChIP-Seq_ESCs_Mouse0.58251730
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.58220677
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.58213359
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.57303275
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.54628797
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.53916079
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53549072
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.53517256
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.52854853
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.52073278
146* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.51859656
147BCOR_27268052_Chip-Seq_Bcells_Human0.51502838
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.51015759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.28640410
2MP0005360_urolithiasis6.73633459
3MP0005085_abnormal_gallbladder_physiolo5.71739526
4MP0005365_abnormal_bile_salt5.50988463
5MP0008875_abnormal_xenobiotic_pharmacok4.47675462
6MP0003806_abnormal_nucleotide_metabolis3.72728011
7MP0003252_abnormal_bile_duct3.56009359
8MP0009840_abnormal_foam_cell3.23203840
9MP0010329_abnormal_lipoprotein_level3.17927760
10MP0001666_abnormal_nutrient_absorption3.10992789
11MP0005083_abnormal_biliary_tract2.85426920
12MP0003195_calcinosis2.75597081
13MP0005332_abnormal_amino_acid2.42599751
14MP0010234_abnormal_vibrissa_follicle2.41832401
15MP0004019_abnormal_vitamin_homeostasis2.40202715
16MP0003941_abnormal_skin_development2.32245016
17MP0003191_abnormal_cellular_cholesterol2.29980853
18MP0005076_abnormal_cell_differentiation2.27733100
19MP0000678_abnormal_parathyroid_gland2.25987558
20MP0002138_abnormal_hepatobiliary_system2.19438982
21MP0003566_abnormal_cell_adhesion2.06169408
22MP0000609_abnormal_liver_physiology1.96219845
23MP0003693_abnormal_embryo_hatching1.79369425
24MP0002118_abnormal_lipid_homeostasis1.78407886
25MP0003868_abnormal_feces_composition1.77163666
26MP0002254_reproductive_system_inflammat1.75423937
27MP0000762_abnormal_tongue_morphology1.67365714
28MP0004264_abnormal_extraembryonic_tissu1.64334805
29MP0003705_abnormal_hypodermis_morpholog1.61197089
30MP0004185_abnormal_adipocyte_glucose1.60413430
31MP0005409_darkened_coat_color1.60239175
32MP0005319_abnormal_enzyme/_coenzyme1.58134356
33MP0002796_impaired_skin_barrier1.52471634
34MP0002249_abnormal_larynx_morphology1.52283181
35MP0004858_abnormal_nervous_system1.49587615
36MP0010030_abnormal_orbit_morphology1.47226827
37MP0009643_abnormal_urine_homeostasis1.46178787
38MP0000383_abnormal_hair_follicle1.45878265
39MP0002089_abnormal_postnatal_growth/wei1.45226142
40MP0004957_abnormal_blastocyst_morpholog1.42272831
41MP0004272_abnormal_basement_membrane1.38366208
42MP0001764_abnormal_homeostasis1.37526068
43MP0003123_paternal_imprinting1.33366062
44MP0010771_integument_phenotype1.25726290
45MP0003011_delayed_dark_adaptation1.23203641
46MP0005451_abnormal_body_composition1.20569599
47MP0001730_embryonic_growth_arrest1.19936293
48MP0005220_abnormal_exocrine_pancreas1.18130186
49MP0003315_abnormal_perineum_morphology1.17361525
50MP0000627_abnormal_mammary_gland1.16619324
51MP0009053_abnormal_anal_canal1.14755359
52MP0000490_abnormal_crypts_of1.13270712
53MP0003186_abnormal_redox_activity1.12782232
54MP0005584_abnormal_enzyme/coenzyme_acti1.09706810
55MP0005257_abnormal_intraocular_pressure1.09243141
56MP0005058_abnormal_lysosome_morphology1.07614658
57* MP0000598_abnormal_liver_morphology1.05926443
58MP0002098_abnormal_vibrissa_morphology1.02438762
59MP0005408_hypopigmentation1.01901506
60* MP0009931_abnormal_skin_appearance1.01562207
61MP0000858_altered_metastatic_potential1.01277575
62MP0003878_abnormal_ear_physiology1.00688979
63MP0005377_hearing/vestibular/ear_phenot1.00688979
64MP0005084_abnormal_gallbladder_morpholo1.00453273
65MP0005636_abnormal_mineral_homeostasis0.98043754
66MP0005647_abnormal_sex_gland0.94260662
67MP0008260_abnormal_autophagy0.92760259
68MP0009697_abnormal_copulation0.91493064
69MP0003453_abnormal_keratinocyte_physiol0.90181172
70MP0001756_abnormal_urination0.87085860
71MP0002086_abnormal_extraembryonic_tissu0.86637502
72MP0005501_abnormal_skin_physiology0.84215865
73MP0002697_abnormal_eye_size0.83045798
74MP0004381_abnormal_hair_follicle0.82403704
75MP0002060_abnormal_skin_morphology0.81702305
76MP0002111_abnormal_tail_morphology0.81602387
77MP0009642_abnormal_blood_homeostasis0.77441418
78MP0009780_abnormal_chondrocyte_physiolo0.77348544
79MP0000579_abnormal_nail_morphology0.76479968
80MP0001672_abnormal_embryogenesis/_devel0.75984098
81MP0005380_embryogenesis_phenotype0.75984098
82MP0008932_abnormal_embryonic_tissue0.75945408
83MP0001664_abnormal_digestion0.75601768
84MP0009763_increased_sensitivity_to0.75588652
85MP0005375_adipose_tissue_phenotype0.74803282
86MP0000003_abnormal_adipose_tissue0.74791279
87MP0010678_abnormal_skin_adnexa0.74563364
88MP0003111_abnormal_nucleus_morphology0.74030835
89MP0000470_abnormal_stomach_morphology0.73795145
90MP0003984_embryonic_growth_retardation0.73537288
91MP0002080_prenatal_lethality0.73104143
92MP0000537_abnormal_urethra_morphology0.72895629
93MP0002078_abnormal_glucose_homeostasis0.71449547
94MP0001216_abnormal_epidermal_layer0.70984899
95MP0003300_gastrointestinal_ulcer0.70984874
96MP0002085_abnormal_embryonic_tissue0.70658620
97MP0004782_abnormal_surfactant_physiolog0.70612838
98MP0010368_abnormal_lymphatic_system0.70370099
99MP0001346_abnormal_lacrimal_gland0.69863533
100MP0003115_abnormal_respiratory_system0.69162884
101MP0002088_abnormal_embryonic_growth/wei0.68872238
102MP0008469_abnormal_protein_level0.68193211
103MP0009764_decreased_sensitivity_to0.67438711
104MP0000350_abnormal_cell_proliferation0.65898842
105MP0002877_abnormal_melanocyte_morpholog0.64926618
106MP0000367_abnormal_coat/_hair0.64727742
107MP0001765_abnormal_ion_homeostasis0.64541599
108MP0000462_abnormal_digestive_system0.64311402
109MP0009384_cardiac_valve_regurgitation0.64276268
110MP0002136_abnormal_kidney_physiology0.63047885
111MP0005248_abnormal_Harderian_gland0.62840432
112MP0003183_abnormal_peptide_metabolism0.62619832
113MP0003718_maternal_effect0.62458563
114MP0000604_amyloidosis0.62172551
115MP0009379_abnormal_foot_pigmentation0.61490826
116MP0009765_abnormal_xenobiotic_induced0.61256704
117MP0001661_extended_life_span0.61171666
118MP0002084_abnormal_developmental_patter0.61122674
119MP0001944_abnormal_pancreas_morphology0.60167371
120MP0005376_homeostasis/metabolism_phenot0.58976632
121MP0003119_abnormal_digestive_system0.58243237
122MP0005670_abnormal_white_adipose0.57955847
123MP0000377_abnormal_hair_follicle0.57376642
124MP0000566_synostosis0.56331812
125MP0002928_abnormal_bile_duct0.55954952
126MP0000427_abnormal_hair_cycle0.55907469
127MP0005395_other_phenotype0.55792039
128MP0000467_abnormal_esophagus_morphology0.55140869
129MP0000538_abnormal_urinary_bladder0.54202768
130MP0003638_abnormal_response/metabolism_0.53557852
131MP0005334_abnormal_fat_pad0.53266823
132MP0004947_skin_inflammation0.52708187
133MP0009672_abnormal_birth_weight0.52599461
134MP0010352_gastrointestinal_tract_polyps0.52282568
135MP0003656_abnormal_erythrocyte_physiolo0.52085551
136MP0003890_abnormal_embryonic-extraembry0.50646904
137MP0005023_abnormal_wound_healing0.49210284
138MP0002971_abnormal_brown_adipose0.48066023
139MP0005266_abnormal_metabolism0.47397868
140MP0000477_abnormal_intestine_morphology0.45822663
141MP0002876_abnormal_thyroid_physiology0.45360840
142MP0005448_abnormal_energy_balance0.44379608
143MP0000613_abnormal_salivary_gland0.43682650
144MP0006036_abnormal_mitochondrial_physio0.43679899
145MP0001881_abnormal_mammary_gland0.43618648
146MP0005666_abnormal_adipose_tissue0.43035035
147MP0003953_abnormal_hormone_level0.42378129
148MP0005275_abnormal_skin_tensile0.42272543
149MP0004043_abnormal_pH_regulation0.42174926
150MP0000639_abnormal_adrenal_gland0.42171133
151MP0001873_stomach_inflammation0.41980246
152MP0001849_ear_inflammation0.41343363
153MP0008004_abnormal_stomach_pH0.40879460

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.02837247
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01002886
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69123589
4Deep venous thrombosis (HP:0002625)6.56681049
5Hypobetalipoproteinemia (HP:0003563)6.15383569
6Xanthomatosis (HP:0000991)5.82588855
7Prolonged partial thromboplastin time (HP:0003645)5.65184601
8Pili torti (HP:0003777)4.93038993
9Complement deficiency (HP:0004431)4.78149964
10Hyperlipoproteinemia (HP:0010980)4.76988087
11Hypoglycemic coma (HP:0001325)4.54870870
12Hypolipoproteinemia (HP:0010981)4.54316786
13Hyperammonemia (HP:0001987)4.28222630
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23242059
15Fat malabsorption (HP:0002630)4.17839084
16Abnormality of the common coagulation pathway (HP:0010990)4.10559527
17Ketosis (HP:0001946)4.08931284
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06413478
19Fragile nails (HP:0001808)4.04554204
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.03087882
21Epidermoid cyst (HP:0200040)4.01088503
22Joint hemorrhage (HP:0005261)3.88117994
23Hyperglycinemia (HP:0002154)3.87893796
24Hypoalphalipoproteinemia (HP:0003233)3.80084475
25Abnormal hair laboratory examination (HP:0003328)3.79554380
26Hyperglycinuria (HP:0003108)3.78268782
27Conjugated hyperbilirubinemia (HP:0002908)3.78003763
28Milia (HP:0001056)3.75905369
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.68625700
30Abnormality of the intrinsic pathway (HP:0010989)3.65406335
31Abnormality of methionine metabolism (HP:0010901)3.64963099
32Abnormality of pyrimidine metabolism (HP:0004353)3.64774889
33Abnormality of complement system (HP:0005339)3.62056731
34Abnormality of serine family amino acid metabolism (HP:0010894)3.52918186
35Abnormality of glycine metabolism (HP:0010895)3.52918186
36Flat acetabular roof (HP:0003180)3.39663671
37Hypercholesterolemia (HP:0003124)3.38706998
38Ketoacidosis (HP:0001993)3.30637852
39Hypoglycemic seizures (HP:0002173)3.28737407
40Plantar hyperkeratosis (HP:0007556)3.25032417
41Onycholysis (HP:0001806)3.24241188
42Late onset (HP:0003584)3.21916353
43Pterygium (HP:0001059)3.20291756
44Abnormality of nucleobase metabolism (HP:0010932)3.11068078
45Selective tooth agenesis (HP:0001592)3.07141698
46Steatorrhea (HP:0002570)3.01309614
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00643958
48Hyperbilirubinemia (HP:0002904)2.99846923
49Abnormality of fatty-acid metabolism (HP:0004359)2.98559954
50Abnormality of nail color (HP:0100643)2.95764449
51Gout (HP:0001997)2.93861467
52Esophageal varix (HP:0002040)2.92946546
53Septate vagina (HP:0001153)2.91379047
54Hyperinsulinemic hypoglycemia (HP:0000825)2.89869690
55Hepatocellular carcinoma (HP:0001402)2.87497929
56Malnutrition (HP:0004395)2.84443239
57Abnormality of purine metabolism (HP:0004352)2.84214673
58Delayed CNS myelination (HP:0002188)2.73678648
59Vascular calcification (HP:0004934)2.73162825
60Ridged nail (HP:0001807)2.71039337
61Right ventricular cardiomyopathy (HP:0011663)2.62251712
62Bronchomalacia (HP:0002780)2.60036449
63Alopecia of scalp (HP:0002293)2.59269831
64Advanced eruption of teeth (HP:0006288)2.59139839
65Spontaneous abortion (HP:0005268)2.51758597
66Myocardial infarction (HP:0001658)2.50424566
67Hyperglycemia (HP:0003074)2.49541707
68Abnormality of serum amino acid levels (HP:0003112)2.48879827
69Metabolic acidosis (HP:0001942)2.47652759
70Spastic diplegia (HP:0001264)2.47274334
71Lethargy (HP:0001254)2.46458553
72Symptomatic seizures (HP:0011145)2.46062540
73Nail dystrophy (HP:0008404)2.45211051
74Skin nodule (HP:0200036)2.45196670
75Atrophic scars (HP:0001075)2.42355696
76Hyperactive renin-angiotensin system (HP:0000841)2.40345186
77Dicarboxylic aciduria (HP:0003215)2.39427713
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39427713
79Hyperacusis (HP:0010780)2.38359031
80Abnormality of the gastric mucosa (HP:0004295)2.38009060
81Broad face (HP:0000283)2.37914711
82Cardiovascular calcification (HP:0011915)2.37454843
83Abnormality of the salivary glands (HP:0010286)2.34997963
84Systemic lupus erythematosus (HP:0002725)2.34261744
85Irritability (HP:0000737)2.33916964
86Hypoplasia of dental enamel (HP:0006297)2.33305010
87Focal segmental glomerulosclerosis (HP:0000097)2.33251962
88Trismus (HP:0000211)2.31759461
89Acanthocytosis (HP:0001927)2.31525533
90Abnormality of the distal phalanges of the toes (HP:0010182)2.29770666
91Sparse eyelashes (HP:0000653)2.29615300
92Amelogenesis imperfecta (HP:0000705)2.28724702
93Hypotrichosis (HP:0001006)2.26289330
94Abnormal gallbladder physiology (HP:0012438)2.25177575
95Cholecystitis (HP:0001082)2.25177575
96Abnormal gallbladder morphology (HP:0012437)2.21482653
97Glomerulonephritis (HP:0000099)2.19885472
98Micronodular cirrhosis (HP:0001413)2.14854614
99Abnormal blistering of the skin (HP:0008066)2.14533905
100Generalized aminoaciduria (HP:0002909)2.14006286
101Deviation of the thumb (HP:0009603)2.11927420
102Ulnar bowing (HP:0003031)2.11831054
103Hydroxyprolinuria (HP:0003080)2.11716135
104Abnormality of proline metabolism (HP:0010907)2.11716135
105Woolly hair (HP:0002224)2.11669023
106Hypochromic microcytic anemia (HP:0004840)2.10697475
107Pancreatitis (HP:0001733)2.10307331
108Abnormality of the distal phalanx of the thumb (HP:0009617)2.09238581
109Abnormality of vitamin metabolism (HP:0100508)2.08712802
110Abnormal tarsal ossification (HP:0008369)2.08588171
111Rickets (HP:0002748)2.08404253
112Abnormality of endocrine pancreas physiology (HP:0012093)2.07516043
113Abnormality of the pancreatic islet cells (HP:0006476)2.07516043
114Glomerulosclerosis (HP:0000096)2.06604752
115Abnormality of the Achilles tendon (HP:0005109)2.06516598
116Neonatal onset (HP:0003623)2.05493246
117Cholelithiasis (HP:0001081)2.05459659
118Distal lower limb muscle weakness (HP:0009053)2.04736518
119Acanthosis nigricans (HP:0000956)2.02320587
120Palmoplantar hyperkeratosis (HP:0000972)2.01751923
121Amyloidosis (HP:0011034)2.01654601
122Abnormality of carpal bone ossification (HP:0006257)2.01137890
123Stridor (HP:0010307)1.99875168
124Brushfield spots (HP:0001088)1.99455937
125Abnormal enzyme/coenzyme activity (HP:0012379)1.99260249
126Diaphragmatic weakness (HP:0009113)1.99183268
127Upper limb amyotrophy (HP:0009129)1.99087838
128Distal upper limb amyotrophy (HP:0007149)1.99087838
129Bifid scrotum (HP:0000048)1.98215016
130Abnormality of transition element cation homeostasis (HP:0011030)1.96970979
131Thick nail (HP:0001805)1.96039354
132Proximal tubulopathy (HP:0000114)1.95825721
133Ankyloglossia (HP:0010296)1.94990442
134Abnormal cartilage morphology (HP:0002763)1.94984871
135Asymmetry of the thorax (HP:0001555)1.94683219
136Lip pit (HP:0100267)1.93469304
137Curly hair (HP:0002212)1.92581725
138Abnormality of urine glucose concentration (HP:0011016)1.91950450
139Glycosuria (HP:0003076)1.91950450
140Enlarged kidneys (HP:0000105)1.91732479
141Thin bony cortex (HP:0002753)1.91086752
142Increased purine levels (HP:0004368)1.90947926
143Hyperuricemia (HP:0002149)1.90947926
144Hyperparathyroidism (HP:0000843)1.90842436
145Abdominal distention (HP:0003270)1.90742192
146Proximal placement of thumb (HP:0009623)1.89953686
147Back pain (HP:0003418)1.88868545
148Germ cell neoplasia (HP:0100728)1.88086541
149Hemorrhage of the eye (HP:0011885)1.86661621
150Achilles tendon contracture (HP:0001771)1.86167807
151Abnormality of the gallbladder (HP:0005264)1.86134184
152Distal lower limb amyotrophy (HP:0008944)1.85779801
153Long palpebral fissure (HP:0000637)1.85022462
154J-shaped sella turcica (HP:0002680)1.84418906
155Cerebral edema (HP:0002181)1.84155743
156Menorrhagia (HP:0000132)1.84000936
157Sensorimotor neuropathy (HP:0007141)1.83038568
158Flattened epiphyses (HP:0003071)1.82964224
159Mitral stenosis (HP:0001718)1.82758966
160Nasolacrimal duct obstruction (HP:0000579)1.82642503
161Fragile skin (HP:0001030)1.82526102
162Abnormality of the lacrimal duct (HP:0011481)1.82200729
163Vomiting (HP:0002013)1.80491269
164Abnormality of alkaline phosphatase activity (HP:0004379)1.79558488
165Natal tooth (HP:0000695)1.79454356
166Palmar hyperkeratosis (HP:0010765)1.79341351
167Progressive hearing impairment (HP:0001730)1.78816967
168Abnormality of the dental root (HP:0006486)1.77985204
169Taurodontia (HP:0000679)1.77985204
170Abnormality of permanent molar morphology (HP:0011071)1.77985204
171Seborrheic dermatitis (HP:0001051)1.77200353
172Abnormal ossification of hand bones (HP:0005921)1.73288305
173Progressive sensorineural hearing impairment (HP:0000408)1.72847489
174Popliteal pterygium (HP:0009756)1.70227630
175Ureteral stenosis (HP:0000071)1.69605358
176Abnormal vertebral ossification (HP:0100569)1.68583018
177Ventricular tachycardia (HP:0004756)1.66488960
178Spinal cord compression (HP:0002176)1.63027491
179Absent eyelashes (HP:0000561)1.62895193
180Anonychia (HP:0001798)1.62452597
181Abnormality of oral frenula (HP:0000190)1.62071017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.84681449
2EPHA24.45200554
3ERN14.34435811
4SMG13.88623231
5FGFR43.21161053
6SIK13.05059356
7MST1R2.97691098
8LATS12.54864932
9PTK62.51635617
10TAOK32.46499491
11MAPK152.45082104
12FRK2.44551496
13INSRR2.38678725
14ERBB42.27359392
15MAP3K32.21177658
16NME22.09633663
17MAP2K22.08155372
18EEF2K2.06617047
19TRIB31.82896240
20PIK3CG1.59331151
21PKN21.59184507
22MET1.57148918
23MAP3K21.52643341
24STK38L1.50195719
25PTK21.48072158
26FLT31.43703133
27MAP3K101.30012104
28FER1.29620759
29MAPK111.26682231
30RPS6KB21.26058762
31KDR1.25426560
32MAP3K111.25190274
33DYRK1B1.20499123
34NME11.15537808
35RIPK11.15313936
36EPHB21.14468696
37MAP3K91.12405083
38WNK31.12269187
39VRK21.10532922
40ERBB21.08110490
41NEK91.05728970
42ARAF1.03108694
43MAP2K31.03096134
44TYK21.01942345
45BMX1.01790429
46CDK60.98722958
47IRAK30.96344200
48MAPKAPK30.91307234
49PRPF4B0.91179340
50MAP2K60.87430216
51PAK40.85730796
52MAP2K10.84562982
53MST40.84066522
54TESK20.81655210
55PASK0.78091666
56STK240.74613317
57ABL20.73983052
58EPHB10.71879692
59MAP3K10.70863990
60LRRK20.70623211
61JAK20.70277342
62MTOR0.69667114
63DAPK20.67990662
64ICK0.67362136
65SCYL20.67342245
66GSK3A0.64544469
67LATS20.64451661
68GRK10.63037654
69PRKAA20.62715921
70GRK60.62062827
71TBK10.60854224
72NUAK10.59944792
73PRKCI0.59941327
74RPS6KA20.59590375
75MAP3K80.59206363
76STK100.58922180
77EPHA30.58856178
78MUSK0.55997199
79TESK10.54285428
80AKT30.53868128
81ILK0.53787133
82SIK30.52748874
83MAP2K40.52313649
84BUB10.52118272
85IRAK20.52099701
86CHUK0.51792546
87MAP3K70.51428172
88CDK40.51346984
89CDK120.50672437
90CDC42BPA0.50330120
91PRKG20.49857225
92NTRK10.49446028
93PDPK10.49381822
94CDK90.48992849
95PRKD20.48021112
96BRAF0.47622652
97CAMK2G0.47425916
98PIM20.47341215
99TIE10.45969004
100WNK40.44742581
101NLK0.43745547
102FGFR20.43627862
103CSK0.43484711
104STK390.42489905
105LMTK20.42449202
106TAOK20.41859270
107RPS6KA40.41702756
108PRKD30.41636302
109PDGFRA0.40433332
110TTN0.39761401
111TGFBR20.39741200
112FGFR10.39650400
113STK30.38858138
114RPS6KC10.38300088
115RPS6KL10.38300088
116AKT20.38237868
117NEK60.38093103
118EIF2AK10.37252912
119MAP3K120.36402660
120TAF10.36400678
121PRKCZ0.35946621
122MAPKAPK20.35813748
123TSSK60.35709953
124PBK0.34278234
125HIPK20.34251956
126DAPK10.33958423
127TGFBR10.32234976
128TAOK10.31449949
129MELK0.31052984
130PRKACG0.30945652
131CAMK1D0.29703791
132PIK3CA0.29479386
133KSR20.28403411
134CSNK1E0.27709246
135FGFR30.27503635
136CDK80.27424850
137RET0.27030783
138PRKAA10.26613406
139MAP3K50.26097068
140ACVR1B0.26002832
141CDK70.26002501
142AURKB0.24681506
143RPS6KA10.24539217
144EGFR0.24363034
145TTK0.22521034

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.05547323
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46085332
3Nitrogen metabolism_Homo sapiens_hsa009103.43081395
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94588397
5Arginine biosynthesis_Homo sapiens_hsa002202.84974913
6Tryptophan metabolism_Homo sapiens_hsa003802.63861622
7Complement and coagulation cascades_Homo sapiens_hsa046102.56714981
8Fatty acid degradation_Homo sapiens_hsa000712.43949518
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42959372
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41404535
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27637280
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27274717
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23593312
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22462441
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.21123521
16Histidine metabolism_Homo sapiens_hsa003402.12240454
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04136672
18Chemical carcinogenesis_Homo sapiens_hsa052041.99856877
19Peroxisome_Homo sapiens_hsa041461.87779281
20Selenocompound metabolism_Homo sapiens_hsa004501.85185705
21Butanoate metabolism_Homo sapiens_hsa006501.80632900
22Caffeine metabolism_Homo sapiens_hsa002321.80256719
23Fat digestion and absorption_Homo sapiens_hsa049751.79799239
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79480046
25Retinol metabolism_Homo sapiens_hsa008301.78252155
26PPAR signaling pathway_Homo sapiens_hsa033201.76954417
27Sulfur metabolism_Homo sapiens_hsa009201.75879841
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.73088455
29beta-Alanine metabolism_Homo sapiens_hsa004101.65485494
30Phenylalanine metabolism_Homo sapiens_hsa003601.65368858
31Fatty acid metabolism_Homo sapiens_hsa012121.63496849
32Propanoate metabolism_Homo sapiens_hsa006401.62578262
33Folate biosynthesis_Homo sapiens_hsa007901.62260106
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58090062
35Bile secretion_Homo sapiens_hsa049761.50680716
36Staphylococcus aureus infection_Homo sapiens_hsa051501.48577048
37Notch signaling pathway_Homo sapiens_hsa043301.47416824
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46010274
39Tyrosine metabolism_Homo sapiens_hsa003501.41883147
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40079294
41Pyruvate metabolism_Homo sapiens_hsa006201.33534459
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.32215907
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32119887
44Other glycan degradation_Homo sapiens_hsa005111.31564070
45Starch and sucrose metabolism_Homo sapiens_hsa005001.31292372
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.29689531
47Biosynthesis of amino acids_Homo sapiens_hsa012301.22552087
48Vitamin digestion and absorption_Homo sapiens_hsa049771.21443225
49ABC transporters_Homo sapiens_hsa020101.19433009
50Fatty acid elongation_Homo sapiens_hsa000621.12759918
51Carbon metabolism_Homo sapiens_hsa012001.12689254
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08081317
53Arginine and proline metabolism_Homo sapiens_hsa003301.02354471
54Glutathione metabolism_Homo sapiens_hsa004801.02286780
55Steroid biosynthesis_Homo sapiens_hsa001001.00456349
56Sulfur relay system_Homo sapiens_hsa041220.92966654
57One carbon pool by folate_Homo sapiens_hsa006700.91324238
58Endometrial cancer_Homo sapiens_hsa052130.90679578
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89433845
60Chronic myeloid leukemia_Homo sapiens_hsa052200.89059747
61Sphingolipid metabolism_Homo sapiens_hsa006000.85456411
62Lysine degradation_Homo sapiens_hsa003100.83264530
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81224526
64Small cell lung cancer_Homo sapiens_hsa052220.80800105
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80294347
66Acute myeloid leukemia_Homo sapiens_hsa052210.79525028
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79132963
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76493404
69Pentose phosphate pathway_Homo sapiens_hsa000300.76384230
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.74539282
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74166730
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71366768
73Glycerolipid metabolism_Homo sapiens_hsa005610.71017104
74Basal cell carcinoma_Homo sapiens_hsa052170.70419836
75DNA replication_Homo sapiens_hsa030300.70071049
76ECM-receptor interaction_Homo sapiens_hsa045120.66480987
77Hippo signaling pathway_Homo sapiens_hsa043900.66049925
78Base excision repair_Homo sapiens_hsa034100.65726931
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65613690
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61150934
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61118034
82Vibrio cholerae infection_Homo sapiens_hsa051100.60840691
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57961962
84Linoleic acid metabolism_Homo sapiens_hsa005910.57085729
85Prostate cancer_Homo sapiens_hsa052150.54405692
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53953433
87Fructose and mannose metabolism_Homo sapiens_hsa000510.52052129
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51196255
89Proteoglycans in cancer_Homo sapiens_hsa052050.50771245
90Galactose metabolism_Homo sapiens_hsa000520.48746986
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48232194
92Metabolic pathways_Homo sapiens_hsa011000.47732651
93Vitamin B6 metabolism_Homo sapiens_hsa007500.46957564
94ErbB signaling pathway_Homo sapiens_hsa040120.46181541
95VEGF signaling pathway_Homo sapiens_hsa043700.43571671
96Non-small cell lung cancer_Homo sapiens_hsa052230.42663835
97Pancreatic cancer_Homo sapiens_hsa052120.41117971
98MicroRNAs in cancer_Homo sapiens_hsa052060.40217525
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38136576
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36766910
101Inositol phosphate metabolism_Homo sapiens_hsa005620.36605946
102Fatty acid biosynthesis_Homo sapiens_hsa000610.36061597
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33916692
104Prion diseases_Homo sapiens_hsa050200.30462087
105Insulin resistance_Homo sapiens_hsa049310.28424623
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.22690476
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.14859865
108Bladder cancer_Homo sapiens_hsa052190.14594188
109Renin-angiotensin system_Homo sapiens_hsa046140.14327631
110Mineral absorption_Homo sapiens_hsa049780.11633890
111Arachidonic acid metabolism_Homo sapiens_hsa005900.11098364
112Glucagon signaling pathway_Homo sapiens_hsa049220.10546535
113Protein export_Homo sapiens_hsa030600.10201055
114Protein digestion and absorption_Homo sapiens_hsa049740.05827893
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02301352
116AMPK signaling pathway_Homo sapiens_hsa041520.01238849
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1241119
118Insulin signaling pathway_Homo sapiens_hsa04910-0.1162441
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1146777
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1048978
121N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1044362
122Tight junction_Homo sapiens_hsa04530-0.0725106
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0528752
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0505511
125Adherens junction_Homo sapiens_hsa04520-0.0497962
126Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0441976
127Thyroid cancer_Homo sapiens_hsa05216-0.0294406
128Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0255268
129Hepatitis C_Homo sapiens_hsa05160-0.0098105

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