LSG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)4.27813776
2mitotic metaphase plate congression (GO:0007080)4.18310559
3nuclear pore organization (GO:0006999)4.16531951
4maturation of SSU-rRNA (GO:0030490)4.04870201
5nuclear pore complex assembly (GO:0051292)4.04720650
6DNA strand elongation involved in DNA replication (GO:0006271)4.03000710
7establishment of integrated proviral latency (GO:0075713)3.89916067
8nucleobase biosynthetic process (GO:0046112)3.89748315
9DNA replication checkpoint (GO:0000076)3.86847298
10DNA strand elongation (GO:0022616)3.85395363
11telomere maintenance via semi-conservative replication (GO:0032201)3.84850941
12non-recombinational repair (GO:0000726)3.83365626
13double-strand break repair via nonhomologous end joining (GO:0006303)3.83365626
14purine nucleobase biosynthetic process (GO:0009113)3.81219139
15IMP biosynthetic process (GO:0006188)3.80497690
16metaphase plate congression (GO:0051310)3.79948512
17formation of translation preinitiation complex (GO:0001731)3.78443049
18* ribosome biogenesis (GO:0042254)3.76902073
19DNA unwinding involved in DNA replication (GO:0006268)3.75910628
20regulation of translational fidelity (GO:0006450)3.74271078
21ribosomal small subunit assembly (GO:0000028)3.73181554
22protein localization to kinetochore (GO:0034501)3.72753763
23mitotic sister chromatid cohesion (GO:0007064)3.72056694
24ribosome assembly (GO:0042255)3.68004625
25mitotic nuclear envelope disassembly (GO:0007077)3.65480916
26sister chromatid segregation (GO:0000819)3.65084456
27DNA replication-dependent nucleosome assembly (GO:0006335)3.64170593
28DNA replication-dependent nucleosome organization (GO:0034723)3.64170593
29telomere maintenance via recombination (GO:0000722)3.62452064
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60550200
31kinetochore organization (GO:0051383)3.58844474
32* ribonucleoprotein complex biogenesis (GO:0022613)3.55703011
33mitotic recombination (GO:0006312)3.53494638
34CENP-A containing nucleosome assembly (GO:0034080)3.50823082
35chromatin remodeling at centromere (GO:0031055)3.48652000
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.47722830
37ribosomal large subunit biogenesis (GO:0042273)3.44342099
38spliceosomal snRNP assembly (GO:0000387)3.42195702
39folic acid-containing compound biosynthetic process (GO:0009396)3.41810817
40regulation of centriole replication (GO:0046599)3.38147926
41establishment of chromosome localization (GO:0051303)3.37277748
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36347754
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35963052
44viral mRNA export from host cell nucleus (GO:0046784)3.33446070
45membrane disassembly (GO:0030397)3.32715423
46nuclear envelope disassembly (GO:0051081)3.32715423
47DNA topological change (GO:0006265)3.32694736
48telomere maintenance via telomere lengthening (GO:0010833)3.32497367
49tRNA aminoacylation for protein translation (GO:0006418)3.29828456
50ribosomal small subunit biogenesis (GO:0042274)3.29364917
51pore complex assembly (GO:0046931)3.29260677
52DNA replication-independent nucleosome organization (GO:0034724)3.28885816
53DNA replication-independent nucleosome assembly (GO:0006336)3.28885816
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.28838721
55regulation of spindle organization (GO:0090224)3.28579765
56regulation of translational termination (GO:0006449)3.28049825
57mitochondrial RNA metabolic process (GO:0000959)3.27133295
58amino acid activation (GO:0043038)3.26189735
59tRNA aminoacylation (GO:0043039)3.26189735
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25830751
61rRNA processing (GO:0006364)3.25366533
62kinetochore assembly (GO:0051382)3.25168500
63protein complex localization (GO:0031503)3.25092083
64IMP metabolic process (GO:0046040)3.21792028
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17712955
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.17712955
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16158268
68protein localization to chromosome, centromeric region (GO:0071459)3.15628521
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15485539
70rRNA metabolic process (GO:0016072)3.15176724
71maturation of 5.8S rRNA (GO:0000460)3.14524933
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12977041
73negative regulation of ligase activity (GO:0051352)3.12977041
74tRNA methylation (GO:0030488)3.11536276
75transcription from mitochondrial promoter (GO:0006390)3.06956560
76transcription-coupled nucleotide-excision repair (GO:0006283)3.06148743
77rRNA modification (GO:0000154)3.05760704
78negative regulation of mRNA processing (GO:0050686)3.05167379
79viral transcription (GO:0019083)3.04662327
80mismatch repair (GO:0006298)3.04149291
81translational termination (GO:0006415)3.03917352
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.03120318
83termination of RNA polymerase I transcription (GO:0006363)3.02736600
84establishment of viral latency (GO:0019043)3.02676439
85Golgi transport vesicle coating (GO:0048200)3.02643446
86COPI coating of Golgi vesicle (GO:0048205)3.02643446
87transcription elongation from RNA polymerase I promoter (GO:0006362)3.02505219
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.02388581
89DNA deamination (GO:0045006)3.02242255
90regulation of helicase activity (GO:0051095)3.00225698
91nuclear envelope organization (GO:0006998)2.98776629
92meiotic chromosome segregation (GO:0045132)2.98056367
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97527330
94DNA duplex unwinding (GO:0032508)2.96802868
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96637396
96DNA geometric change (GO:0032392)2.96202490
97negative regulation of mRNA metabolic process (GO:1903312)2.95206031
98regulation of chromosome segregation (GO:0051983)2.93499478
99spliceosomal complex assembly (GO:0000245)2.93246466
100mitotic sister chromatid segregation (GO:0000070)2.93120030
101mitotic chromosome condensation (GO:0007076)2.93053129
102telomere organization (GO:0032200)2.92890951
103telomere maintenance (GO:0000723)2.92811947
104somatic recombination of immunoglobulin gene segments (GO:0016447)2.92415995
105spindle checkpoint (GO:0031577)2.92343617
106translational initiation (GO:0006413)2.92288054
107attachment of spindle microtubules to kinetochore (GO:0008608)2.91893512
108regulation of mitotic spindle organization (GO:0060236)2.90284289
109proteasome assembly (GO:0043248)2.90020799
110histone exchange (GO:0043486)2.89924030
111termination of RNA polymerase III transcription (GO:0006386)2.89467909
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.89467909
113regulation of mitochondrial translation (GO:0070129)2.88905686
114transcription from RNA polymerase I promoter (GO:0006360)2.87178601
115cellular protein complex localization (GO:0034629)2.86993577
116regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83970454
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83970454
118DNA ligation (GO:0006266)2.83341557
119DNA conformation change (GO:0071103)2.82778801
120negative regulation of chromosome segregation (GO:0051985)2.80848053
121negative regulation of sister chromatid segregation (GO:0033046)2.80111616
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.80111616
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80111616
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80111616
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.78051759
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78051759
127mitotic spindle checkpoint (GO:0071174)2.77984578
128spindle assembly checkpoint (GO:0071173)2.77593974
129regulation of centrosome cycle (GO:0046605)2.76606417
130positive regulation of chromosome segregation (GO:0051984)2.74455388
131pseudouridine synthesis (GO:0001522)2.73784982
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73576466
133mitotic spindle assembly checkpoint (GO:0007094)2.73471075
134translational elongation (GO:0006414)2.73033099
135transcription initiation from RNA polymerase I promoter (GO:0006361)2.72114113
136protein K6-linked ubiquitination (GO:0085020)2.72075909
137G1/S transition of mitotic cell cycle (GO:0000082)2.71944308
138cell cycle G1/S phase transition (GO:0044843)2.71944308
139replication fork processing (GO:0031297)2.71782126
140RNA splicing, via transesterification reactions (GO:0000375)2.71282386
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71248973
142regulation of gene silencing by miRNA (GO:0060964)2.70825456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59916045
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.15551530
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.96675717
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73283316
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26536874
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19057279
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.04979924
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02484037
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02249786
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86682931
11* GABP_17652178_ChIP-ChIP_JURKAT_Human2.85418793
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82491348
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.73491401
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71584517
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50763746
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39743287
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34615107
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25689409
19* VDR_23849224_ChIP-Seq_CD4+_Human2.25655899
20* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24544993
21* XRN2_22483619_ChIP-Seq_HELA_Human2.19347498
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16870825
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12676566
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06812127
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02191772
26* FOXP3_21729870_ChIP-Seq_TREG_Human2.00799359
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00579758
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95580950
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.94898969
30AR_21909140_ChIP-Seq_LNCAP_Human1.94064611
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.87022641
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86621358
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86523280
34ELK1_19687146_ChIP-ChIP_HELA_Human1.84886985
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.84836782
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80956528
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80750307
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78246774
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76078467
40TTF2_22483619_ChIP-Seq_HELA_Human1.73929248
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73045286
42* GABP_19822575_ChIP-Seq_HepG2_Human1.72305604
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71979697
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69306157
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67514639
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64814685
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.61785811
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56906740
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.56823425
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54328646
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51411176
52CIITA_25753668_ChIP-Seq_RAJI_Human1.48594493
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47089422
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44459014
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.44248924
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.44193989
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43329649
58KDM5A_27292631_Chip-Seq_BREAST_Human1.43056944
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42332500
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40562550
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33855823
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28308309
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27573920
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27246019
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26355601
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24346790
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23846586
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21267413
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.21081814
70MYC_22102868_ChIP-Seq_BL_Human1.19135011
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18703888
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18166235
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17742141
74* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17085145
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16997846
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16758707
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16319081
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16319081
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16319081
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13727695
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13593881
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13462803
83TFEB_21752829_ChIP-Seq_HELA_Human1.12039741
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11807453
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09833154
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09253483
87CHD1_26751641_Chip-Seq_LNCaP_Human1.08365751
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04630576
89MYC_18940864_ChIP-ChIP_HL60_Human1.04112634
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03490734
91ZNF263_19887448_ChIP-Seq_K562_Human0.99702509
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99658099
93* ELF5_23300383_ChIP-Seq_T47D_Human0.96545098
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96114808
95SPI1_23547873_ChIP-Seq_NB4_Human0.93964450
96* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93058693
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92116000
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.91342834
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90772748
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88624136
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87818469
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87692656
103* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87655067
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87217003
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86215588
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85991884
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82674460
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81500403
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.80924665
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80710313
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79339349
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78631896
113* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77490981
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76617702
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75179771
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74962416
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74865444
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74692961
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74117283
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.72588467
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72042503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.17054931
2MP0010094_abnormal_chromosome_stability4.33302535
3MP0003111_abnormal_nucleus_morphology4.21554294
4MP0008057_abnormal_DNA_replication4.08174053
5MP0004957_abnormal_blastocyst_morpholog4.01387845
6MP0003077_abnormal_cell_cycle3.77052846
7MP0008058_abnormal_DNA_repair3.63062330
8MP0008007_abnormal_cellular_replicative2.78038955
9MP0010234_abnormal_vibrissa_follicle2.75726471
10MP0008932_abnormal_embryonic_tissue2.42426752
11MP0002396_abnormal_hematopoietic_system2.24245610
12MP0003786_premature_aging2.13632968
13MP0001730_embryonic_growth_arrest2.06656415
14MP0000350_abnormal_cell_proliferation2.02455260
15MP0002254_reproductive_system_inflammat2.00907855
16MP0010352_gastrointestinal_tract_polyps1.96367578
17MP0002877_abnormal_melanocyte_morpholog1.94379041
18MP0003123_paternal_imprinting1.80956166
19MP0002009_preneoplasia1.79151775
20MP0002796_impaired_skin_barrier1.78688135
21MP0006292_abnormal_olfactory_placode1.72299739
22MP0008877_abnormal_DNA_methylation1.70056940
23MP0001672_abnormal_embryogenesis/_devel1.66792329
24MP0005380_embryogenesis_phenotype1.66792329
25MP0003718_maternal_effect1.66052213
26MP0004185_abnormal_adipocyte_glucose1.65423269
27MP0010307_abnormal_tumor_latency1.64079807
28MP0003763_abnormal_thymus_physiology1.55695890
29MP0004233_abnormal_muscle_weight1.47389757
30MP0001697_abnormal_embryo_size1.46111087
31MP0000490_abnormal_crypts_of1.45239259
32MP0010678_abnormal_skin_adnexa1.45115481
33MP0003984_embryonic_growth_retardation1.44840907
34MP0002132_abnormal_respiratory_system1.43204022
35MP0009333_abnormal_splenocyte_physiolog1.41900865
36MP0002088_abnormal_embryonic_growth/wei1.41514023
37MP0010030_abnormal_orbit_morphology1.40033664
38MP0002085_abnormal_embryonic_tissue1.39606330
39MP0002080_prenatal_lethality1.39183645
40MP0002019_abnormal_tumor_incidence1.38345839
41MP0004264_abnormal_extraembryonic_tissu1.37679259
42MP0001293_anophthalmia1.36031162
43MP0000313_abnormal_cell_death1.35895205
44MP0001661_extended_life_span1.34275584
45MP0001727_abnormal_embryo_implantation1.32429873
46MP0002084_abnormal_developmental_patter1.31038514
47MP0004197_abnormal_fetal_growth/weight/1.30695843
48MP0000372_irregular_coat_pigmentation1.26952789
49MP0003890_abnormal_embryonic-extraembry1.26438594
50MP0002086_abnormal_extraembryonic_tissu1.25535101
51MP0003941_abnormal_skin_development1.22521672
52MP0005408_hypopigmentation1.22433590
53MP0004808_abnormal_hematopoietic_stem1.21551828
54MP0001216_abnormal_epidermal_layer1.19095958
55MP0003806_abnormal_nucleotide_metabolis1.18018905
56MP0000383_abnormal_hair_follicle1.16396442
57MP0000703_abnormal_thymus_morphology1.14475176
58MP0000858_altered_metastatic_potential1.11628071
59MP0002210_abnormal_sex_determination1.10003780
60MP0003121_genomic_imprinting1.09744199
61MP0000627_abnormal_mammary_gland1.08841629
62MP0000377_abnormal_hair_follicle1.08305038
63MP0002166_altered_tumor_susceptibility1.08112480
64MP0002398_abnormal_bone_marrow1.08059169
65MP0002098_abnormal_vibrissa_morphology1.03849842
66MP0002060_abnormal_skin_morphology1.03205144
67MP0002006_tumorigenesis1.03109973
68MP0000689_abnormal_spleen_morphology1.02874947
69MP0003567_abnormal_fetal_cardiomyocyte1.02629676
70MP0002722_abnormal_immune_system1.01168234
71MP0005397_hematopoietic_system_phenotyp0.99798257
72MP0001545_abnormal_hematopoietic_system0.99798257
73MP0001881_abnormal_mammary_gland0.98957083
74MP0005451_abnormal_body_composition0.96697777
75MP0001286_abnormal_eye_development0.96174805
76MP0003566_abnormal_cell_adhesion0.95755405
77MP0000427_abnormal_hair_cycle0.94491866
78MP0001849_ear_inflammation0.94070986
79MP0001145_abnormal_male_reproductive0.93525319
80MP0008260_abnormal_autophagy0.93334582
81MP0002938_white_spotting0.92571897
82MP0003656_abnormal_erythrocyte_physiolo0.92069212
83MP0003943_abnormal_hepatobiliary_system0.91766786
84MP0004133_heterotaxia0.91309153
85MP0006035_abnormal_mitochondrial_morpho0.91060211
86MP0005671_abnormal_response_to0.88725135
87MP0003136_yellow_coat_color0.88234884
88MP0005075_abnormal_melanosome_morpholog0.87312601
89MP0003937_abnormal_limbs/digits/tail_de0.87265883
90MP0003186_abnormal_redox_activity0.86889070
91MP0003315_abnormal_perineum_morphology0.86620623
92MP0009697_abnormal_copulation0.86295107
93MP0001119_abnormal_female_reproductive0.86161668
94MP0000467_abnormal_esophagus_morphology0.85445965
95MP0002429_abnormal_blood_cell0.85223232
96MP0002111_abnormal_tail_morphology0.84930642
97MP0004782_abnormal_surfactant_physiolog0.84445512
98MP0001348_abnormal_lacrimal_gland0.84372115
99MP0003119_abnormal_digestive_system0.84275001
100MP0002405_respiratory_system_inflammati0.82692486
101MP0003950_abnormal_plasma_membrane0.80393246
102MP0005389_reproductive_system_phenotype0.79211948
103MP0010771_integument_phenotype0.79124937
104MP0009703_decreased_birth_body0.78840184
105MP0000647_abnormal_sebaceous_gland0.78199907
106MP0009053_abnormal_anal_canal0.77760922
107MP0003221_abnormal_cardiomyocyte_apopto0.77756649
108MP0000653_abnormal_sex_gland0.77407227
109MP0001929_abnormal_gametogenesis0.77172509
110MP0000716_abnormal_immune_system0.76548080
111MP0003453_abnormal_keratinocyte_physiol0.75325034
112MP0005083_abnormal_biliary_tract0.75081528
113MP0001346_abnormal_lacrimal_gland0.74515074
114MP0001800_abnormal_humoral_immune0.74356454
115MP0001243_abnormal_dermal_layer0.74198499
116MP0008961_abnormal_basal_metabolism0.73798010
117MP0001873_stomach_inflammation0.73710888
118MP0002102_abnormal_ear_morphology0.72558440
119MP0002160_abnormal_reproductive_system0.72057552
120MP0000579_abnormal_nail_morphology0.71799368
121MP0002092_abnormal_eye_morphology0.71394687
122MP0005384_cellular_phenotype0.71023906
123MP0001915_intracranial_hemorrhage0.70200072
124MP0005076_abnormal_cell_differentiation0.69607401
125MP0005621_abnormal_cell_physiology0.68256721
126MP0001919_abnormal_reproductive_system0.67783269
127MP0003868_abnormal_feces_composition0.67706011
128MP0006036_abnormal_mitochondrial_physio0.67423553
129MP0000432_abnormal_head_morphology0.66733887
130MP0005023_abnormal_wound_healing0.66690858
131MP0002452_abnormal_antigen_presenting0.66379178
132MP0002420_abnormal_adaptive_immunity0.66367350
133MP0001819_abnormal_immune_cell0.65504947
134MP0001835_abnormal_antigen_presentation0.65205743
135MP0000537_abnormal_urethra_morphology0.64380878
136MP0009931_abnormal_skin_appearance0.64377255
137MP0000358_abnormal_cell_content/0.64247386
138MP0003936_abnormal_reproductive_system0.64104794
139MP0009672_abnormal_birth_weight0.63850703
140MP0001191_abnormal_skin_condition0.63583399
141MP0003448_altered_tumor_morphology0.63268661
142MP0000428_abnormal_craniofacial_morphol0.63233326
143MP0004381_abnormal_hair_follicle0.63131714
144MP0002095_abnormal_skin_pigmentation0.63009933
145MP0005501_abnormal_skin_physiology0.62928017
146MP0001853_heart_inflammation0.62732465
147MP0009278_abnormal_bone_marrow0.62254477
148MP0000516_abnormal_urinary_system0.62034966
149MP0005367_renal/urinary_system_phenotyp0.62034966
150MP0000566_synostosis0.61904192

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.78221673
2Chromsome breakage (HP:0040012)4.29767593
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26387260
4Microvesicular hepatic steatosis (HP:0001414)3.95060655
5Reticulocytopenia (HP:0001896)3.86564933
6Breast hypoplasia (HP:0003187)3.79665848
7Cutaneous melanoma (HP:0012056)3.55117971
8Selective tooth agenesis (HP:0001592)3.43255630
9Patellar aplasia (HP:0006443)3.34578601
10Progressive muscle weakness (HP:0003323)3.33270651
11Meckel diverticulum (HP:0002245)3.23917199
12Abnormality of chromosome stability (HP:0003220)3.22699572
13Abnormality of the preputium (HP:0100587)3.22511713
14Aplasia/Hypoplasia of the patella (HP:0006498)3.10457032
15Abnormality of the ileum (HP:0001549)3.10267786
16Ependymoma (HP:0002888)3.08888367
17Impulsivity (HP:0100710)3.06885751
18Multiple enchondromatosis (HP:0005701)3.05691520
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.97931190
20Medulloblastoma (HP:0002885)2.97702990
21Degeneration of anterior horn cells (HP:0002398)2.90675897
22Abnormality of the anterior horn cell (HP:0006802)2.90675897
23Colon cancer (HP:0003003)2.88386107
24Absent radius (HP:0003974)2.79960296
25Abnormality of cells of the erythroid lineage (HP:0012130)2.77762283
26Agnosia (HP:0010524)2.71702804
27Carpal bone hypoplasia (HP:0001498)2.69953931
28Entropion (HP:0000621)2.69543777
29Rough bone trabeculation (HP:0100670)2.69426786
30Supernumerary spleens (HP:0009799)2.69320033
31Absent thumb (HP:0009777)2.68595058
32Ectopic kidney (HP:0000086)2.63910199
33Abnormal number of erythroid precursors (HP:0012131)2.62424097
34Myelodysplasia (HP:0002863)2.61444771
35Cerebral hypomyelination (HP:0006808)2.60466322
36Abnormal number of incisors (HP:0011064)2.59820381
37Premature graying of hair (HP:0002216)2.59691494
38Aplasia involving forearm bones (HP:0009822)2.58938776
39Absent forearm bone (HP:0003953)2.58938776
40Sparse lateral eyebrow (HP:0005338)2.53964672
41Oral leukoplakia (HP:0002745)2.51213755
42Bone marrow hypocellularity (HP:0005528)2.46745577
43Progressive external ophthalmoplegia (HP:0000590)2.45859978
44Hyperacusis (HP:0010780)2.45441985
45Duplicated collecting system (HP:0000081)2.44220048
46Abnormality of the labia minora (HP:0012880)2.39886659
47Duodenal stenosis (HP:0100867)2.39120791
48Small intestinal stenosis (HP:0012848)2.39120791
49Insidious onset (HP:0003587)2.32757554
50Termporal pattern (HP:0011008)2.32757554
51Horseshoe kidney (HP:0000085)2.30900282
52Aplastic anemia (HP:0001915)2.30096160
53Poikiloderma (HP:0001029)2.29770762
54Pallor (HP:0000980)2.28910069
55Type I transferrin isoform profile (HP:0003642)2.28679415
56Deep philtrum (HP:0002002)2.28519521
57Rhabdomyosarcoma (HP:0002859)2.28216168
58Macrocytic anemia (HP:0001972)2.27287752
59Microglossia (HP:0000171)2.26117712
60Neoplasm of the pancreas (HP:0002894)2.25855114
61Increased nuchal translucency (HP:0010880)2.25641281
62Pili torti (HP:0003777)2.25509056
63Sloping forehead (HP:0000340)2.25452696
64Triphalangeal thumb (HP:0001199)2.24407236
65Clubbing of toes (HP:0100760)2.23602201
6611 pairs of ribs (HP:0000878)2.21925435
67Abnormality of methionine metabolism (HP:0010901)2.21071407
68Abnormality of the umbilical cord (HP:0010881)2.18772951
69Abnormality of the renal collecting system (HP:0004742)2.18593677
70Spastic paraparesis (HP:0002313)2.17829661
71Lymphoma (HP:0002665)2.17179802
72Sparse eyelashes (HP:0000653)2.17108073
73Trismus (HP:0000211)2.16905980
74IgA deficiency (HP:0002720)2.15961348
75T lymphocytopenia (HP:0005403)2.15740332
76Overriding aorta (HP:0002623)2.14461609
77Posterior subcapsular cataract (HP:0007787)2.13322382
78Abnormality of the duodenum (HP:0002246)2.12822812
79Severe combined immunodeficiency (HP:0004430)2.10238510
80Amaurosis fugax (HP:0100576)2.09379889
81Cellular immunodeficiency (HP:0005374)2.09049663
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08185128
83Breast carcinoma (HP:0003002)2.08015506
84Abnormal protein glycosylation (HP:0012346)2.06211591
85Abnormal glycosylation (HP:0012345)2.06211591
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06211591
87Abnormal protein N-linked glycosylation (HP:0012347)2.06211591
88Abnormal trabecular bone morphology (HP:0100671)2.05502325
89Spastic diplegia (HP:0001264)2.05247197
90Abnormality of DNA repair (HP:0003254)2.03639784
91Tracheoesophageal fistula (HP:0002575)2.03565055
92Combined immunodeficiency (HP:0005387)2.03119781
93Squamous cell carcinoma (HP:0002860)2.02714558
94Glioma (HP:0009733)2.01399005
95Abnormal lung lobation (HP:0002101)2.01236230
96Reduced antithrombin III activity (HP:0001976)2.01083438
97Increased serum lactate (HP:0002151)2.00907908
98Ragged-red muscle fibers (HP:0003200)2.00769071
99Proximal placement of thumb (HP:0009623)2.00355379
100Short thumb (HP:0009778)1.99542271
101Deviation of the thumb (HP:0009603)1.98869287
102Hypergonadotropic hypogonadism (HP:0000815)1.98768612
103Abnormality of T cell number (HP:0011839)1.96032136
104Melanoma (HP:0002861)1.94014801
105Lipid accumulation in hepatocytes (HP:0006561)1.92820916
106Secondary amenorrhea (HP:0000869)1.90303767
107Abnormality of glycolysis (HP:0004366)1.89925905
108Pelvic girdle muscle weakness (HP:0003749)1.87209465
109Abnormality of the astrocytes (HP:0100707)1.85469372
110Astrocytoma (HP:0009592)1.85469372
111Abnormal hair laboratory examination (HP:0003328)1.85018526
112Basal cell carcinoma (HP:0002671)1.83894258
113Autoamputation (HP:0001218)1.83365075
114Prominent nose (HP:0000448)1.83058948
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82831397
116Atresia of the external auditory canal (HP:0000413)1.82524663
117Choanal atresia (HP:0000453)1.82479995
118Nephroblastoma (Wilms tumor) (HP:0002667)1.81921512
119Premature ovarian failure (HP:0008209)1.81853006
120Thrombocytosis (HP:0001894)1.81683722
121Rib fusion (HP:0000902)1.81535760
122Increased hepatocellular lipid droplets (HP:0006565)1.80966733
123Acute myeloid leukemia (HP:0004808)1.80876497
124Curly hair (HP:0002212)1.80297968
125Abnormality of oral frenula (HP:0000190)1.79107703
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.78419249
127Osteolytic defects of the hand bones (HP:0009699)1.78419249
128Asplenia (HP:0001746)1.78064926
129Postnatal microcephaly (HP:0005484)1.77626212
130Optic nerve coloboma (HP:0000588)1.77404339
131Cleft eyelid (HP:0000625)1.75802742
132Abnormality of the carotid arteries (HP:0005344)1.75211552
133Ureteral duplication (HP:0000073)1.74745284
134Facial cleft (HP:0002006)1.72234069
135Shoulder girdle muscle weakness (HP:0003547)1.72194653
136Volvulus (HP:0002580)1.72048332
137Anal stenosis (HP:0002025)1.71877177
138Micronodular cirrhosis (HP:0001413)1.71786803
139Embryonal renal neoplasm (HP:0011794)1.71125545
140Elfin facies (HP:0004428)1.71003927
141Insomnia (HP:0100785)1.70732749
142High pitched voice (HP:0001620)1.70232329
143Abnormality of pyrimidine metabolism (HP:0004353)1.69770727
144Sandal gap (HP:0001852)1.67893257
145Neoplasm of striated muscle (HP:0009728)1.66276866
146Pancytopenia (HP:0001876)1.65853038
147Hypoplasia of the radius (HP:0002984)1.65826724
148Prostate neoplasm (HP:0100787)1.65680643
149IgM deficiency (HP:0002850)1.65468721
150Microretrognathia (HP:0000308)1.65402900
151Aplasia/hypoplasia of the humerus (HP:0006507)1.64828943
152Cafe-au-lait spot (HP:0000957)1.63825502
153Abnormal spermatogenesis (HP:0008669)1.62910644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.00301534
2WEE13.71614890
3CDC73.40707596
4SRPK12.94136190
5EIF2AK12.89754771
6TSSK62.55303554
7TTK2.52170383
8PLK42.39182239
9NEK22.35331326
10SMG12.20540045
11VRK22.19471138
12ZAK2.14535626
13MKNK12.09840963
14EPHA22.07315271
15BRSK22.04038270
16MKNK21.99590524
17TLK11.95430352
18PLK11.93754657
19EIF2AK31.93443341
20ATR1.90782689
21CDK71.85573676
22STK161.85290443
23MST1R1.84914816
24VRK11.81411066
25CDK121.81107628
26ACVR1B1.76417280
27PASK1.68998474
28AURKB1.68356563
29PLK31.65772754
30NME21.61265335
31BRD41.54696569
32RPS6KB21.52422963
33TESK21.51330919
34DYRK31.38239067
35STK101.36734609
36CHEK21.34896936
37TXK1.31086219
38TRIM281.27117287
39NME11.26774405
40RPS6KA41.26126344
41MAP3K101.25497221
42CHEK11.23655432
43MAP3K81.20020526
44PIM11.14754321
45TGFBR11.13284893
46CDK41.13160285
47PDK21.13096138
48EIF2AK21.12403486
49STK41.11487290
50NEK11.07611587
51ICK1.03707486
52TAF11.02979668
53AURKA1.02560135
54ATM1.01636006
55PBK1.01163620
56MAP4K10.95537822
57YES10.92952495
58CDK80.91462943
59STK30.89839230
60BRSK10.87966510
61PIM20.87128245
62MST40.84490911
63PAK40.83384548
64CDK20.82321511
65MET0.79223522
66SIK30.78673556
67MELK0.76218191
68NEK60.74990290
69TRIB30.74255415
70CSNK2A20.73692400
71IRAK30.73343667
72ERBB40.72564116
73CSNK2A10.72178669
74AKT30.70961473
75KDR0.69495935
76RPS6KA50.67912460
77CDK10.65219098
78STK38L0.64748938
79NUAK10.61844297
80IKBKB0.56925904
81CCNB10.56160093
82BCKDK0.55520938
83LATS10.55395411
84PRKCI0.55122974
85DYRK20.54959128
86CHUK0.54089720
87NLK0.54008981
88PAK20.51594791
89CDK60.51516880
90ZAP700.51279865
91BRAF0.50884830
92RAF10.50795928
93MAP2K30.49709175
94MAPKAPK30.48672630
95PAK10.48541203
96MARK30.48004332
97CDK30.47889351
98BLK0.47560854
99ALK0.47243578
100BTK0.45854820
101CDK90.45428326
102ITK0.43243589
103MAP2K20.42155853
104CLK10.40788410
105MAP3K140.40264240
106ILK0.40075127
107TEC0.39202736
108TAOK20.39033481
109FLT30.37684336
110SIK10.37437070
111IRAK40.36853476
112BMPR1B0.36490916
113CSNK1E0.36444737
114SCYL20.36068817
115MAPK110.35738512
116CSK0.34618747
117MTOR0.34540066
118PRKDC0.32686039
119TTN0.31942133
120AKT20.31800462
121BMPR20.31762025
122LYN0.31702883
123LRRK20.31170820
124MAP3K50.30647085
125PNCK0.30628227
126MAPK140.30147204
127EEF2K0.29633522
128DAPK10.28569743
129MAP3K30.27962594
130MAPKAPK20.26467392
131FGFR10.26136946
132PRPF4B0.21995767
133PTK20.20254637

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18348514
2Mismatch repair_Homo sapiens_hsa034303.87828197
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79215670
4RNA polymerase_Homo sapiens_hsa030203.36210183
5Spliceosome_Homo sapiens_hsa030403.22651184
6Homologous recombination_Homo sapiens_hsa034403.06151712
7Ribosome_Homo sapiens_hsa030103.05495717
8Proteasome_Homo sapiens_hsa030503.03060205
9RNA transport_Homo sapiens_hsa030133.00548886
10Base excision repair_Homo sapiens_hsa034102.73699847
11Nucleotide excision repair_Homo sapiens_hsa034202.71634984
12One carbon pool by folate_Homo sapiens_hsa006702.69607620
13Fanconi anemia pathway_Homo sapiens_hsa034602.58158075
14Cell cycle_Homo sapiens_hsa041102.53836262
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38298729
16Pyrimidine metabolism_Homo sapiens_hsa002402.32959435
17Non-homologous end-joining_Homo sapiens_hsa034502.30093219
18Basal transcription factors_Homo sapiens_hsa030222.08978670
19RNA degradation_Homo sapiens_hsa030181.95729552
20p53 signaling pathway_Homo sapiens_hsa041151.73357581
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70905533
22mRNA surveillance pathway_Homo sapiens_hsa030151.64721785
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62636855
24Epstein-Barr virus infection_Homo sapiens_hsa051691.25759155
25Systemic lupus erythematosus_Homo sapiens_hsa053221.24088807
26Purine metabolism_Homo sapiens_hsa002301.23783881
27Primary immunodeficiency_Homo sapiens_hsa053401.17156832
28Vitamin B6 metabolism_Homo sapiens_hsa007501.16978926
29N-Glycan biosynthesis_Homo sapiens_hsa005101.16846576
30Herpes simplex infection_Homo sapiens_hsa051681.16459970
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11777813
32Antigen processing and presentation_Homo sapiens_hsa046120.98405986
33Folate biosynthesis_Homo sapiens_hsa007900.96877151
34Viral carcinogenesis_Homo sapiens_hsa052030.96374192
35Protein export_Homo sapiens_hsa030600.95405222
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92381755
37Carbon metabolism_Homo sapiens_hsa012000.91672439
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89608372
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.85630134
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82476398
41Fatty acid elongation_Homo sapiens_hsa000620.79935931
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76960168
43Sulfur relay system_Homo sapiens_hsa041220.75625062
44Measles_Homo sapiens_hsa051620.74739795
45HTLV-I infection_Homo sapiens_hsa051660.72100933
46Legionellosis_Homo sapiens_hsa051340.67889826
47Caffeine metabolism_Homo sapiens_hsa002320.65613278
48Selenocompound metabolism_Homo sapiens_hsa004500.65098679
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.64962343
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.63995730
51MicroRNAs in cancer_Homo sapiens_hsa052060.63156107
52Pyruvate metabolism_Homo sapiens_hsa006200.62348100
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.62097800
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61016692
55Hematopoietic cell lineage_Homo sapiens_hsa046400.60502291
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59395399
57Small cell lung cancer_Homo sapiens_hsa052220.57953269
58Graft-versus-host disease_Homo sapiens_hsa053320.57554942
59Chronic myeloid leukemia_Homo sapiens_hsa052200.57085732
60Propanoate metabolism_Homo sapiens_hsa006400.56113688
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55733705
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.54449314
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54254730
64Pentose phosphate pathway_Homo sapiens_hsa000300.53554040
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53210410
66Apoptosis_Homo sapiens_hsa042100.52686165
67Allograft rejection_Homo sapiens_hsa053300.51825647
68Pancreatic cancer_Homo sapiens_hsa052120.50799473
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50052680
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47192548
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46884230
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46295923
73Thyroid cancer_Homo sapiens_hsa052160.46008161
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44684899
75Oocyte meiosis_Homo sapiens_hsa041140.44529410
76Basal cell carcinoma_Homo sapiens_hsa052170.43471945
77Biosynthesis of amino acids_Homo sapiens_hsa012300.43181574
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42541379
79Glutathione metabolism_Homo sapiens_hsa004800.42415897
80TGF-beta signaling pathway_Homo sapiens_hsa043500.41707293
81Notch signaling pathway_Homo sapiens_hsa043300.39844758
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39155163
83Autoimmune thyroid disease_Homo sapiens_hsa053200.39049143
84Influenza A_Homo sapiens_hsa051640.38830181
85Fatty acid metabolism_Homo sapiens_hsa012120.37976961
86Non-small cell lung cancer_Homo sapiens_hsa052230.37267480
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36359750
88Sphingolipid metabolism_Homo sapiens_hsa006000.36119403
89Hepatitis B_Homo sapiens_hsa051610.36103578
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.35962543
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35193683
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34593672
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34202381
94Hippo signaling pathway_Homo sapiens_hsa043900.33740515
95Endometrial cancer_Homo sapiens_hsa052130.33643802
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31442873
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30198060
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27816596
99Shigellosis_Homo sapiens_hsa051310.26848180
100Asthma_Homo sapiens_hsa053100.26846763
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.26779962
102Hepatitis C_Homo sapiens_hsa051600.25944526
103T cell receptor signaling pathway_Homo sapiens_hsa046600.24468123
104Huntingtons disease_Homo sapiens_hsa050160.24147661
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23995903
106Arachidonic acid metabolism_Homo sapiens_hsa005900.23223926
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22488623
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22101378
109Pathways in cancer_Homo sapiens_hsa052000.22097915
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21357894
111Prostate cancer_Homo sapiens_hsa052150.21318774
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21285155
113Colorectal cancer_Homo sapiens_hsa052100.20126413
114Metabolic pathways_Homo sapiens_hsa011000.19741019
115Vitamin digestion and absorption_Homo sapiens_hsa049770.19071997
116Proteoglycans in cancer_Homo sapiens_hsa052050.18278775
117Alcoholism_Homo sapiens_hsa050340.17891452
118Acute myeloid leukemia_Homo sapiens_hsa052210.17356417
119Fructose and mannose metabolism_Homo sapiens_hsa000510.17297699
120Arginine and proline metabolism_Homo sapiens_hsa003300.16873299
121Viral myocarditis_Homo sapiens_hsa054160.16051740
122Leishmaniasis_Homo sapiens_hsa051400.15807460
123Adherens junction_Homo sapiens_hsa045200.15048796
124Lysine degradation_Homo sapiens_hsa003100.14965609
125Type I diabetes mellitus_Homo sapiens_hsa049400.14950845
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13762614
127Bladder cancer_Homo sapiens_hsa052190.13715730

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