LSAMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81733814
2vocalization behavior (GO:0071625)5.24973267
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18256652
4synaptic vesicle maturation (GO:0016188)5.15805804
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.05392332
6neuron cell-cell adhesion (GO:0007158)5.01777226
7* locomotory exploration behavior (GO:0035641)5.00041378
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99334762
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95038076
10synaptic vesicle exocytosis (GO:0016079)4.89953689
11glutamate secretion (GO:0014047)4.76504030
12regulation of glutamate receptor signaling pathway (GO:1900449)4.65002231
13glutamate receptor signaling pathway (GO:0007215)4.59523154
14regulation of synaptic vesicle exocytosis (GO:2000300)4.56009378
15protein localization to synapse (GO:0035418)4.50903383
16gamma-aminobutyric acid transport (GO:0015812)4.48785458
17synaptic transmission, glutamatergic (GO:0035249)4.33220627
18cellular potassium ion homeostasis (GO:0030007)4.28552088
19neuronal action potential propagation (GO:0019227)4.25226783
20neurotransmitter secretion (GO:0007269)4.19837319
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15854977
22* exploration behavior (GO:0035640)4.10445058
23neurotransmitter-gated ion channel clustering (GO:0072578)4.08894816
24regulation of neuronal synaptic plasticity (GO:0048168)4.07585727
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05152595
26regulation of synaptic vesicle transport (GO:1902803)4.05116900
27layer formation in cerebral cortex (GO:0021819)4.04608314
28pyrimidine nucleobase catabolic process (GO:0006208)4.01066436
29neuron-neuron synaptic transmission (GO:0007270)4.00565366
30proline transport (GO:0015824)3.99045242
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.93605908
32long-term memory (GO:0007616)3.92394837
33axon ensheathment in central nervous system (GO:0032291)3.91491064
34central nervous system myelination (GO:0022010)3.91491064
35dendritic spine morphogenesis (GO:0060997)3.86937061
36sodium ion export (GO:0071436)3.85590645
37transmission of nerve impulse (GO:0019226)3.81611837
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79304336
39neuron recognition (GO:0008038)3.77866381
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.76773877
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71519369
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70941460
43L-amino acid import (GO:0043092)3.70121003
44regulation of synapse structural plasticity (GO:0051823)3.66843892
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62678773
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.62454713
47postsynaptic membrane organization (GO:0001941)3.61029951
48neurotransmitter transport (GO:0006836)3.57755393
49axonal fasciculation (GO:0007413)3.55412624
50mechanosensory behavior (GO:0007638)3.53284963
51cell communication by electrical coupling (GO:0010644)3.52442278
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52337853
53regulation of postsynaptic membrane potential (GO:0060078)3.47728545
54positive regulation of synapse assembly (GO:0051965)3.47465100
55dendrite morphogenesis (GO:0048813)3.47256029
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45215951
57positive regulation of membrane potential (GO:0045838)3.44563069
58presynaptic membrane assembly (GO:0097105)3.43944420
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42605127
60response to auditory stimulus (GO:0010996)3.41639121
61cerebellar granule cell differentiation (GO:0021707)3.41058978
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.39560834
63nucleobase catabolic process (GO:0046113)3.36292590
64response to pheromone (GO:0019236)3.35634023
65regulation of neurotransmitter levels (GO:0001505)3.33335488
66regulation of synaptic plasticity (GO:0048167)3.32359470
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31570400
68synaptic vesicle endocytosis (GO:0048488)3.30678591
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30670730
70long-term synaptic potentiation (GO:0060291)3.27531310
71cerebellar Purkinje cell differentiation (GO:0021702)3.25954834
72response to histamine (GO:0034776)3.24757722
73amino acid import (GO:0043090)3.23952235
74auditory behavior (GO:0031223)3.20891946
75positive regulation of synapse maturation (GO:0090129)3.18993484
76neuronal ion channel clustering (GO:0045161)3.18959222
77regulation of neurotransmitter secretion (GO:0046928)3.16813839
78presynaptic membrane organization (GO:0097090)3.16800105
79neuromuscular process controlling balance (GO:0050885)3.15847522
80innervation (GO:0060384)3.15703779
81regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14646008
82regulation of dendritic spine morphogenesis (GO:0061001)3.14501317
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14131152
84synapse assembly (GO:0007416)3.11957079
85regulation of vesicle fusion (GO:0031338)3.11475167
86neuromuscular process controlling posture (GO:0050884)3.10362151
87serotonin metabolic process (GO:0042428)3.09844450
88glycine transport (GO:0015816)3.09093015
89activation of protein kinase A activity (GO:0034199)3.06085788
90cellular sodium ion homeostasis (GO:0006883)3.05944278
91membrane depolarization during action potential (GO:0086010)3.03648103
92membrane depolarization (GO:0051899)3.02828066
93membrane hyperpolarization (GO:0060081)3.02333966
94behavioral fear response (GO:0001662)3.01754276
95behavioral defense response (GO:0002209)3.01754276
96positive regulation of potassium ion transmembrane transport (GO:1901381)3.01394385
97learning (GO:0007612)3.01064242
98potassium ion import (GO:0010107)2.99511477
99cell migration in hindbrain (GO:0021535)2.99444705
100establishment of mitochondrion localization (GO:0051654)2.99145021
101neuromuscular synaptic transmission (GO:0007274)2.97500261
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96992772
103positive regulation of dendritic spine development (GO:0060999)2.96878156
104startle response (GO:0001964)2.94801516
105regulation of neurotransmitter transport (GO:0051588)2.94756233
106prepulse inhibition (GO:0060134)2.93539038
107adult walking behavior (GO:0007628)2.92985070
108central nervous system projection neuron axonogenesis (GO:0021952)2.91242232
109synapse organization (GO:0050808)2.89637066
110regulation of respiratory system process (GO:0044065)2.89323815
111neuronal action potential (GO:0019228)2.89263507
112potassium ion homeostasis (GO:0055075)2.88518927
113regulation of synaptic transmission (GO:0050804)2.88078982
114synaptic transmission (GO:0007268)2.86787584
115glycosphingolipid biosynthetic process (GO:0006688)2.85185365
116primary amino compound metabolic process (GO:1901160)2.78364637
117regulation of synapse assembly (GO:0051963)2.77889843
118regulation of voltage-gated calcium channel activity (GO:1901385)2.76999780
119C4-dicarboxylate transport (GO:0015740)2.76006836
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.75971221
121regulation of synapse maturation (GO:0090128)2.75369089
122adult behavior (GO:0030534)2.75013674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76643812
2GBX2_23144817_ChIP-Seq_PC3_Human3.75950090
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09589308
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05569086
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04169879
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65317596
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65317596
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58934016
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58251257
10REST_21632747_ChIP-Seq_MESCs_Mouse2.57067305
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54962099
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46594681
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45859047
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.45831695
15DROSHA_22980978_ChIP-Seq_HELA_Human2.44295150
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40654837
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.38232609
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.18453438
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.17979155
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14575451
21AR_21572438_ChIP-Seq_LNCaP_Human2.13350448
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.11438053
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05612270
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02759069
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01933708
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.00019389
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98399635
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84842613
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76291888
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72666580
31TAF15_26573619_Chip-Seq_HEK293_Human1.71421223
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.70738498
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70483644
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63277318
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60397811
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57977097
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53297523
38P300_19829295_ChIP-Seq_ESCs_Human1.51032459
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45870086
40ZNF274_21170338_ChIP-Seq_K562_Hela1.45320145
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43495014
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.41284869
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40889191
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37957199
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37834460
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.37222284
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35532995
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.35509520
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32567822
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.32360957
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31900903
52VDR_22108803_ChIP-Seq_LS180_Human1.31656557
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.31634743
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31245160
55* AR_25329375_ChIP-Seq_VCAP_Human1.30613467
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.30576702
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29250385
58* STAT3_23295773_ChIP-Seq_U87_Human1.28625272
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27977671
60IGF1R_20145208_ChIP-Seq_DFB_Human1.27828796
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25251818
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24766792
63AR_19668381_ChIP-Seq_PC3_Human1.22919747
64TP53_16413492_ChIP-PET_HCT116_Human1.16645661
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15605621
66* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15102886
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14664077
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14162408
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13105404
70* TCF4_23295773_ChIP-Seq_U87_Human1.12640236
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11647399
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10997949
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10820350
74* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09867382
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.08576683
76RNF2_27304074_Chip-Seq_NSC_Mouse1.07561919
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07462221
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.06809313
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06745075
80* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05422743
81RUNX2_22187159_ChIP-Seq_PCA_Human1.05200334
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04900129
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03844659
84AHR_22903824_ChIP-Seq_MCF-7_Human1.02372901
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01289242
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01289242
87TP53_18474530_ChIP-ChIP_U2OS_Human0.99922873
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99690958
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99113556
90* FUS_26573619_Chip-Seq_HEK293_Human0.98962100
91* BCAT_22108803_ChIP-Seq_LS180_Human0.98908566
92KDM2B_26808549_Chip-Seq_REH_Human0.98890449
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98414321
94* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98403364
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.98139161
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97674395
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.96975759
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96722378
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96160880
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95830681
101ER_23166858_ChIP-Seq_MCF-7_Human0.95235726
102* SOX9_26525672_Chip-Seq_HEART_Mouse0.94831279
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.94557265
104CBP_20019798_ChIP-Seq_JUKART_Human0.94267372
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94267372
106* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94101037
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.93637910
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90761671
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90737076
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.90284980
111JUN_21703547_ChIP-Seq_K562_Human0.89247367
112* RXR_22108803_ChIP-Seq_LS180_Human0.88794399
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86641528
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86606556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19830015
2MP0003880_abnormal_central_pattern4.80771574
3MP0003635_abnormal_synaptic_transmissio4.04717868
4MP0004270_analgesia3.54662564
5MP0009745_abnormal_behavioral_response3.37710848
6MP0009046_muscle_twitch3.26244454
7MP0002064_seizures3.17461083
8* MP0002063_abnormal_learning/memory/cond3.16417957
9MP0005423_abnormal_somatic_nervous3.03477086
10MP0001968_abnormal_touch/_nociception2.94373894
11* MP0002572_abnormal_emotion/affect_behav2.77967658
12MP0001486_abnormal_startle_reflex2.77075504
13MP0002272_abnormal_nervous_system2.61257230
14MP0002734_abnormal_mechanical_nocicepti2.58769895
15MP0001501_abnormal_sleep_pattern2.35570942
16MP0002736_abnormal_nociception_after2.34745609
17MP0002735_abnormal_chemical_nociception2.24427910
18* MP0001440_abnormal_grooming_behavior2.18512148
19MP0002067_abnormal_sensory_capabilities2.07840497
20MP0002733_abnormal_thermal_nociception2.03711289
21MP0004858_abnormal_nervous_system2.00408429
22MP0000778_abnormal_nervous_system1.99859002
23MP0009780_abnormal_chondrocyte_physiolo1.97061783
24MP0003329_amyloid_beta_deposits1.96414297
25MP0008569_lethality_at_weaning1.93640285
26MP0001970_abnormal_pain_threshold1.93615118
27MP0005646_abnormal_pituitary_gland1.86852660
28MP0002184_abnormal_innervation1.84525905
29MP0004885_abnormal_endolymph1.84000703
30MP0006276_abnormal_autonomic_nervous1.83772398
31* MP0002557_abnormal_social/conspecific_i1.76085267
32MP0005386_behavior/neurological_phenoty1.75492640
33MP0004924_abnormal_behavior1.75492640
34MP0002822_catalepsy1.68523425
35MP0005645_abnormal_hypothalamus_physiol1.64179427
36MP0000955_abnormal_spinal_cord1.58377438
37MP0004811_abnormal_neuron_physiology1.55014526
38MP0004142_abnormal_muscle_tone1.53639192
39MP0001984_abnormal_olfaction1.48666317
40MP0002882_abnormal_neuron_morphology1.47846459
41* MP0002066_abnormal_motor_capabilities/c1.42482330
42MP0002909_abnormal_adrenal_gland1.39994324
43MP0001529_abnormal_vocalization1.39451903
44MP0001502_abnormal_circadian_rhythm1.39427835
45MP0003633_abnormal_nervous_system1.39020409
46MP0003122_maternal_imprinting1.38910661
47MP0003690_abnormal_glial_cell1.38493473
48MP0003136_yellow_coat_color1.35890165
49MP0001905_abnormal_dopamine_level1.34128854
50MP0003879_abnormal_hair_cell1.30689527
51MP0003787_abnormal_imprinting1.30189464
52MP0003121_genomic_imprinting1.26574032
53MP0003631_nervous_system_phenotype1.21592326
54MP0004742_abnormal_vestibular_system1.16968321
55MP0005551_abnormal_eye_electrophysiolog1.15097521
56MP0002152_abnormal_brain_morphology1.14677638
57MP0000566_synostosis1.13234666
58MP0003634_abnormal_glial_cell1.08475634
59MP0004145_abnormal_muscle_electrophysio1.06658569
60MP0002229_neurodegeneration1.06421567
61MP0000920_abnormal_myelination1.06233974
62MP0008877_abnormal_DNA_methylation1.05306601
63MP0001188_hyperpigmentation1.04969416
64MP0002653_abnormal_ependyma_morphology1.04267418
65MP0003632_abnormal_nervous_system1.01054905
66MP0001963_abnormal_hearing_physiology0.97724041
67MP0004133_heterotaxia0.97093649
68MP0000751_myopathy0.95670676
69MP0000569_abnormal_digit_pigmentation0.94936023
70MP0001986_abnormal_taste_sensitivity0.93000782
71MP0001485_abnormal_pinna_reflex0.91987209
72MP0002069_abnormal_eating/drinking_beha0.89875539
73MP0008872_abnormal_physiological_respon0.88469866
74MP0002638_abnormal_pupillary_reflex0.87373974
75MP0001299_abnormal_eye_distance/0.87254442
76MP0002752_abnormal_somatic_nervous0.86967273
77MP0000604_amyloidosis0.86517985
78MP0001177_atelectasis0.84809697
79MP0004215_abnormal_myocardial_fiber0.83798266
80MP0000631_abnormal_neuroendocrine_gland0.83394960
81MP0003123_paternal_imprinting0.81756803
82MP0006292_abnormal_olfactory_placode0.80648251
83MP0005409_darkened_coat_color0.80281780
84MP0004085_abnormal_heartbeat0.80133357
85MP0003137_abnormal_impulse_conducting0.78847744
86MP0003119_abnormal_digestive_system0.78685259
87MP0008874_decreased_physiological_sensi0.76540704
88MP0002090_abnormal_vision0.76412647
89MP0002751_abnormal_autonomic_nervous0.75503642
90MP0003938_abnormal_ear_development0.74621141
91MP0002102_abnormal_ear_morphology0.72680742
92MP0005535_abnormal_body_temperature0.72572184
93MP0002234_abnormal_pharynx_morphology0.70190690
94MP0003283_abnormal_digestive_organ0.70048447
95MP0004043_abnormal_pH_regulation0.68585647
96MP0002938_white_spotting0.67854019
97MP0003075_altered_response_to0.67727684
98MP0005195_abnormal_posterior_eye0.67445861
99MP0005187_abnormal_penis_morphology0.66013644
100MP0003172_abnormal_lysosome_physiology0.65305737
101MP0005171_absent_coat_pigmentation0.65047094
102MP0006072_abnormal_retinal_apoptosis0.64814984
103MP0004484_altered_response_of0.64643575
104MP0000026_abnormal_inner_ear0.64568487
105MP0005394_taste/olfaction_phenotype0.64278189
106MP0005499_abnormal_olfactory_system0.64278189
107MP0004147_increased_porphyrin_level0.62696223
108MP0005167_abnormal_blood-brain_barrier0.62691393
109MP0005253_abnormal_eye_physiology0.60518795
110MP0001664_abnormal_digestion0.58765044
111MP0003861_abnormal_nervous_system0.57936997
112MP0010386_abnormal_urinary_bladder0.57405958
113MP0001943_abnormal_respiration0.56948928
114MP0005623_abnormal_meninges_morphology0.56148530
115MP0010769_abnormal_survival0.54663605
116MP0008961_abnormal_basal_metabolism0.54597176
117MP0010770_preweaning_lethality0.53083837
118MP0002082_postnatal_lethality0.53083837
119MP0004233_abnormal_muscle_weight0.52334922
120MP0004510_myositis0.51736517

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.50025817
2Myokymia (HP:0002411)6.00554685
3Focal seizures (HP:0007359)5.63306846
4Visual hallucinations (HP:0002367)4.88263669
5Epileptic encephalopathy (HP:0200134)4.75349816
6Progressive cerebellar ataxia (HP:0002073)4.70964633
7Atonic seizures (HP:0010819)4.42734966
8Febrile seizures (HP:0002373)4.34435068
9Action tremor (HP:0002345)4.17281606
10Absence seizures (HP:0002121)4.03243679
11Supranuclear gaze palsy (HP:0000605)3.89585760
12Generalized tonic-clonic seizures (HP:0002069)3.82160637
13Dialeptic seizures (HP:0011146)3.75374961
14Broad-based gait (HP:0002136)3.56714350
15Neurofibrillary tangles (HP:0002185)3.42107179
16Dysdiadochokinesis (HP:0002075)3.36980474
17Hyperventilation (HP:0002883)3.28407173
18Gaze-evoked nystagmus (HP:0000640)3.26294657
19Abnormality of binocular vision (HP:0011514)3.19361922
20Diplopia (HP:0000651)3.19361922
21Dysmetria (HP:0001310)3.16712260
22Hemiparesis (HP:0001269)3.14892130
23Abnormal eating behavior (HP:0100738)3.14071906
24Truncal ataxia (HP:0002078)3.09746050
25Cerebral inclusion bodies (HP:0100314)3.06776948
26Mutism (HP:0002300)3.04320064
27Ankle clonus (HP:0011448)3.01013632
28Megalencephaly (HP:0001355)3.00045420
29Postural instability (HP:0002172)2.95623338
30Depression (HP:0000716)2.95440713
31Impaired vibration sensation in the lower limbs (HP:0002166)2.91858284
32Poor eye contact (HP:0000817)2.86681709
33Genetic anticipation (HP:0003743)2.86567841
34Urinary bladder sphincter dysfunction (HP:0002839)2.81889079
35Excessive salivation (HP:0003781)2.80751871
36Drooling (HP:0002307)2.80751871
37Anxiety (HP:0000739)2.79548479
38Hemiplegia (HP:0002301)2.76476428
39Aplasia involving bones of the extremities (HP:0009825)2.74878595
40Aplasia involving bones of the upper limbs (HP:0009823)2.74878595
41Aplasia of the phalanges of the hand (HP:0009802)2.74878595
42Intention tremor (HP:0002080)2.67618494
43Abnormal social behavior (HP:0012433)2.67611926
44Impaired social interactions (HP:0000735)2.67611926
45Scanning speech (HP:0002168)2.65405374
46Papilledema (HP:0001085)2.60251310
47Progressive inability to walk (HP:0002505)2.58953002
48Polyphagia (HP:0002591)2.57755047
49Abnormality of the corticospinal tract (HP:0002492)2.52435733
50Spastic gait (HP:0002064)2.47476292
51Amblyopia (HP:0000646)2.46283578
52Limb dystonia (HP:0002451)2.41533292
53Impaired smooth pursuit (HP:0007772)2.40981610
54Status epilepticus (HP:0002133)2.40045730
55Fetal akinesia sequence (HP:0001989)2.39199402
56Absent speech (HP:0001344)2.38575534
57Epileptiform EEG discharges (HP:0011182)2.36244994
58Bradykinesia (HP:0002067)2.35164734
59Pheochromocytoma (HP:0002666)2.34144804
60Urinary urgency (HP:0000012)2.27506631
61EEG with generalized epileptiform discharges (HP:0011198)2.25326683
62Abnormality of ocular smooth pursuit (HP:0000617)2.22823934
63Stereotypic behavior (HP:0000733)2.18985650
64Medial flaring of the eyebrow (HP:0010747)2.17974737
65Insidious onset (HP:0003587)2.17640786
66Termporal pattern (HP:0011008)2.17640786
67Lower limb muscle weakness (HP:0007340)2.15219282
68Sleep apnea (HP:0010535)2.14070206
69Hypsarrhythmia (HP:0002521)2.13596540
70True hermaphroditism (HP:0010459)2.13084627
71Congenital primary aphakia (HP:0007707)2.09390962
72Nephronophthisis (HP:0000090)2.07530946
73Protruding tongue (HP:0010808)2.07152791
74Generalized myoclonic seizures (HP:0002123)2.06955928
75Blue irides (HP:0000635)2.04935156
76Torticollis (HP:0000473)2.04521461
77Agitation (HP:0000713)2.04007261
78Abnormality of the lower motor neuron (HP:0002366)2.01620062
79Neuroendocrine neoplasm (HP:0100634)2.01580124
80Pancreatic fibrosis (HP:0100732)1.99810864
81Hepatoblastoma (HP:0002884)1.99787366
82Genital tract atresia (HP:0001827)1.99456844
83Akinesia (HP:0002304)1.98762250
84Vaginal atresia (HP:0000148)1.97186363
85Inability to walk (HP:0002540)1.96401178
86Aqueductal stenosis (HP:0002410)1.96142557
87Impaired vibratory sensation (HP:0002495)1.95441213
88Nephrogenic diabetes insipidus (HP:0009806)1.94443086
89Oligodactyly (hands) (HP:0001180)1.93847022
90Psychosis (HP:0000709)1.92815696
91Abnormality of the labia minora (HP:0012880)1.92767508
92Morphological abnormality of the pyramidal tract (HP:0002062)1.91766363
93Neuronal loss in central nervous system (HP:0002529)1.91692120
94Abnormality of salivation (HP:0100755)1.91658565
95Gait ataxia (HP:0002066)1.90984228
96Spastic tetraplegia (HP:0002510)1.90329568
97Focal dystonia (HP:0004373)1.90031721
98Molar tooth sign on MRI (HP:0002419)1.89948338
99Abnormality of midbrain morphology (HP:0002418)1.89948338
100Amyotrophic lateral sclerosis (HP:0007354)1.88965831
101Clumsiness (HP:0002312)1.88396922
102Peripheral hypomyelination (HP:0007182)1.84566349
103Dysmetric saccades (HP:0000641)1.83181305
104Pancreatic cysts (HP:0001737)1.81660793
105Hypoplasia of the corpus callosum (HP:0002079)1.81169145
106Incomplete penetrance (HP:0003829)1.80420413
107Rigidity (HP:0002063)1.80398489
108Ventricular fibrillation (HP:0001663)1.78279218
109Gait imbalance (HP:0002141)1.76780948
110Abnormality of saccadic eye movements (HP:0000570)1.76338321
111Optic nerve hypoplasia (HP:0000609)1.76112172
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75580356
113Narrow nasal bridge (HP:0000446)1.74571753
114Cutaneous finger syndactyly (HP:0010554)1.74440522
115Retinal dysplasia (HP:0007973)1.73712128
116Specific learning disability (HP:0001328)1.72513807
117Esotropia (HP:0000565)1.72380101
118Lissencephaly (HP:0001339)1.69839492
119Inappropriate behavior (HP:0000719)1.69215912
120Poor coordination (HP:0002370)1.68899157
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68707721
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.68707721
123Insomnia (HP:0100785)1.68130131
124Postural tremor (HP:0002174)1.67126654
125Abnormal EKG (HP:0003115)1.66218099
126Polydipsia (HP:0001959)1.66202547
127Abnormal drinking behavior (HP:0030082)1.66202547
128Abnormality of the renal medulla (HP:0100957)1.65107409
129Failure to thrive in infancy (HP:0001531)1.64063184
130Vitreoretinal degeneration (HP:0000655)1.62772097
131Cystic liver disease (HP:0006706)1.61783204
132Split foot (HP:0001839)1.60549796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.65169047
2EPHA43.96439415
3MARK13.57907153
4MAP3K93.35967809
5MAP3K42.96834135
6TNIK2.93412247
7NTRK22.64478272
8MINK12.62781206
9MAP2K72.53015793
10FRK2.23252180
11CASK2.20102341
12PAK62.00816294
13NTRK11.82424748
14MAP2K41.81106064
15MAPK131.80251450
16MAP3K121.75592613
17PHKG21.63851160
18PHKG11.63851160
19DAPK21.63699862
20KSR21.59327787
21PNCK1.59325513
22RIPK41.58938734
23PRKD31.52735301
24CDK51.50004443
25CAMKK11.47530634
26PRPF4B1.45414482
27DYRK21.40668393
28KSR11.39708524
29SIK21.35082339
30PRKCG1.33898644
31PLK21.32642831
32FES1.28203928
33INSRR1.26488528
34GRK51.24611796
35STK381.21576325
36TYRO31.16614326
37LMTK21.11758925
38CAMK2A1.11563828
39CDK191.09822272
40DAPK11.05053767
41UHMK11.05019431
42SGK4941.00085303
43SGK2231.00085303
44MAP3K130.99790232
45BMPR1B0.99281542
46CAMKK20.98668320
47LATS20.96508842
48SGK20.90173816
49MAP3K20.89622156
50CAMK2B0.89129969
51OXSR10.88905244
52CAMK10.88040465
53ARAF0.86700928
54CDK180.85399398
55CDK150.84680614
56PAK30.83152116
57CDK140.82921511
58CSNK1G20.82400828
59ADRBK20.79110464
60STK110.78852972
61CAMK1G0.77062931
62PRKCH0.76919266
63RET0.75129783
64SGK10.74953021
65DYRK1A0.74301894
66WNK10.73917548
67CDK11A0.73079763
68SGK30.71623253
69CSNK1G30.71359135
70MARK20.69232920
71NEK60.68887630
72FGR0.68443445
73CSNK1A1L0.67801044
74MAP4K20.66317148
75CSNK1G10.63963222
76PINK10.63668779
77PRKCE0.61159729
78CAMK40.59575537
79BMPR20.58584409
80CAMK2D0.58036990
81MAPK150.57579897
82PKN10.56691446
83PTK2B0.56553771
84MUSK0.56521549
85AKT30.56405835
86ALK0.56347713
87CAMK2G0.55441278
88MKNK20.55347241
89TNK20.54897341
90STK390.54563563
91RAF10.52866545
92TAOK10.52309684
93FYN0.51850118
94PRKCZ0.51454910
95EPHA30.51258632
96RPS6KA30.50770609
97ERBB20.50523822
98PDK10.50041431
99CDC42BPA0.49706803
100PDPK10.48666356
101GRK10.48263425
102PRKACA0.47642960
103WNK30.47594315
104MAPK120.47262282
105WNK40.46317863
106ROCK20.46061770
107MAPK100.45744312
108CSNK1D0.44840205
109NME10.43759135
110FGFR20.42149720
111MAP3K60.41148356
112DMPK0.40799702
113SIK30.40426173
114ERBB30.38813157
115CSNK1E0.38637244
116EPHB20.38084538
117FER0.37964330
118CSNK1A10.37594419
119BCR0.37508701
120ADRBK10.37127753
121PRKG10.36674101
122MAP3K70.33903867
123PRKCB0.33784768
124MAPKAPK50.33526494
125ROCK10.33468878
126PRKACB0.32944021
127PRKCA0.32791984
128CDK30.32453338
129GSK3B0.30743832
130LIMK10.30377632

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.09234301
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94077753
3GABAergic synapse_Homo sapiens_hsa047272.81092211
4Glutamatergic synapse_Homo sapiens_hsa047242.76198403
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73699981
6Circadian entrainment_Homo sapiens_hsa047132.65726793
7Long-term potentiation_Homo sapiens_hsa047202.61982913
8Morphine addiction_Homo sapiens_hsa050322.47646896
9Olfactory transduction_Homo sapiens_hsa047402.39309815
10Amphetamine addiction_Homo sapiens_hsa050312.32496244
11Salivary secretion_Homo sapiens_hsa049702.25004461
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11441622
13Dopaminergic synapse_Homo sapiens_hsa047282.05136842
14Insulin secretion_Homo sapiens_hsa049111.94447062
15Gastric acid secretion_Homo sapiens_hsa049711.90493618
16Taste transduction_Homo sapiens_hsa047421.84778185
17Cholinergic synapse_Homo sapiens_hsa047251.83336482
18Long-term depression_Homo sapiens_hsa047301.77957305
19Serotonergic synapse_Homo sapiens_hsa047261.75408647
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68903973
21Renin secretion_Homo sapiens_hsa049241.65213557
22Cocaine addiction_Homo sapiens_hsa050301.62678560
23Calcium signaling pathway_Homo sapiens_hsa040201.61588505
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56441457
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53157386
26Oxytocin signaling pathway_Homo sapiens_hsa049211.52555752
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42577920
28GnRH signaling pathway_Homo sapiens_hsa049121.34988459
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32852348
30cAMP signaling pathway_Homo sapiens_hsa040241.29622498
31Gap junction_Homo sapiens_hsa045401.28997815
32Axon guidance_Homo sapiens_hsa043601.28942236
33Nitrogen metabolism_Homo sapiens_hsa009101.28093356
34Collecting duct acid secretion_Homo sapiens_hsa049661.26236820
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23195736
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22282435
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15819467
38Type II diabetes mellitus_Homo sapiens_hsa049301.13345459
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08849951
40Estrogen signaling pathway_Homo sapiens_hsa049151.07682427
41Butanoate metabolism_Homo sapiens_hsa006501.01629750
42Glioma_Homo sapiens_hsa052141.00327483
43Melanogenesis_Homo sapiens_hsa049161.00189307
44Cardiac muscle contraction_Homo sapiens_hsa042600.99871472
45ErbB signaling pathway_Homo sapiens_hsa040120.98175539
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97164075
47Dorso-ventral axis formation_Homo sapiens_hsa043200.96817542
48Pancreatic secretion_Homo sapiens_hsa049720.95905823
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.90142072
50Phototransduction_Homo sapiens_hsa047440.89410505
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88369180
52Ether lipid metabolism_Homo sapiens_hsa005650.87270723
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86797560
54Choline metabolism in cancer_Homo sapiens_hsa052310.79651015
55Thyroid hormone synthesis_Homo sapiens_hsa049180.79439044
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78681168
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73826169
58Vibrio cholerae infection_Homo sapiens_hsa051100.73625204
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72181798
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72134691
61Fatty acid biosynthesis_Homo sapiens_hsa000610.72074700
62Oocyte meiosis_Homo sapiens_hsa041140.69259490
63Hedgehog signaling pathway_Homo sapiens_hsa043400.69166537
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67652786
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66824610
66MAPK signaling pathway_Homo sapiens_hsa040100.66690080
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65953455
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64965591
69Vitamin B6 metabolism_Homo sapiens_hsa007500.64942665
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63693442
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61751271
72Bile secretion_Homo sapiens_hsa049760.61331268
73Hippo signaling pathway_Homo sapiens_hsa043900.60445064
74Ras signaling pathway_Homo sapiens_hsa040140.59970235
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58736287
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.57925658
77Linoleic acid metabolism_Homo sapiens_hsa005910.55134851
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52392216
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.51661701
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51092619
81Rap1 signaling pathway_Homo sapiens_hsa040150.50976845
82Glucagon signaling pathway_Homo sapiens_hsa049220.50176966
83Basal cell carcinoma_Homo sapiens_hsa052170.48095245
84Circadian rhythm_Homo sapiens_hsa047100.47691051
85VEGF signaling pathway_Homo sapiens_hsa043700.47273993
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47035286
87Wnt signaling pathway_Homo sapiens_hsa043100.45770824
88Inositol phosphate metabolism_Homo sapiens_hsa005620.43204013
89Histidine metabolism_Homo sapiens_hsa003400.43045248
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.41958330
91Alcoholism_Homo sapiens_hsa050340.41805057
92Renal cell carcinoma_Homo sapiens_hsa052110.41803192
93Ovarian steroidogenesis_Homo sapiens_hsa049130.41405285
94Alzheimers disease_Homo sapiens_hsa050100.41006611
95Prion diseases_Homo sapiens_hsa050200.39891720
96Mineral absorption_Homo sapiens_hsa049780.39811173
97African trypanosomiasis_Homo sapiens_hsa051430.39740940
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39624082
99beta-Alanine metabolism_Homo sapiens_hsa004100.39422552
100ABC transporters_Homo sapiens_hsa020100.38005406
101Endocytosis_Homo sapiens_hsa041440.37899301
102Type I diabetes mellitus_Homo sapiens_hsa049400.37594982
103mTOR signaling pathway_Homo sapiens_hsa041500.37165306
104Endometrial cancer_Homo sapiens_hsa052130.34993547
105Regulation of autophagy_Homo sapiens_hsa041400.34492348
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.33955571
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33418991
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32533420
109Tight junction_Homo sapiens_hsa045300.32253435
110Insulin signaling pathway_Homo sapiens_hsa049100.32158552
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31607610
112Parkinsons disease_Homo sapiens_hsa050120.31041881
113Oxidative phosphorylation_Homo sapiens_hsa001900.30601046
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29460991
115Non-small cell lung cancer_Homo sapiens_hsa052230.26600518
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26228078
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26085319
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26011440

Most similar genes based on co-expression Upload to Enrichr

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