LRRTM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.78737614
2neuron cell-cell adhesion (GO:0007158)5.74838397
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52380229
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.44097095
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.34448999
6neurotransmitter-gated ion channel clustering (GO:0072578)5.25325298
7synaptic vesicle exocytosis (GO:0016079)5.13574528
8locomotory exploration behavior (GO:0035641)4.88185156
9regulation of glutamate receptor signaling pathway (GO:1900449)4.85877798
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.84628138
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.79288074
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.79059735
13presynaptic membrane assembly (GO:0097105)4.76232688
14protein localization to synapse (GO:0035418)4.75778815
15neuronal action potential propagation (GO:0019227)4.75618902
16regulation of synaptic vesicle exocytosis (GO:2000300)4.58584816
17neuron-neuron synaptic transmission (GO:0007270)4.53769409
18glutamate secretion (GO:0014047)4.52218134
19synaptic transmission, glutamatergic (GO:0035249)4.46864987
20glutamate receptor signaling pathway (GO:0007215)4.43178000
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.41393566
22presynaptic membrane organization (GO:0097090)4.39300315
23neurotransmitter secretion (GO:0007269)4.36229281
24postsynaptic membrane organization (GO:0001941)4.32073933
25synaptic vesicle maturation (GO:0016188)4.28729233
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.27097910
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.26299839
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.24974144
29cellular potassium ion homeostasis (GO:0030007)4.20567766
30pyrimidine nucleobase catabolic process (GO:0006208)4.15823544
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.13060995
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.12391999
33regulation of synaptic vesicle transport (GO:1902803)4.05822307
34long-term synaptic potentiation (GO:0060291)3.99352858
35cerebellar granule cell differentiation (GO:0021707)3.94125125
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92714904
37regulation of synaptic transmission, glutamatergic (GO:0051966)3.90127233
38exploration behavior (GO:0035640)3.87806749
39startle response (GO:0001964)3.87232218
40gamma-aminobutyric acid transport (GO:0015812)3.86160948
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.81224268
42sodium ion export (GO:0071436)3.78943152
43response to histamine (GO:0034776)3.78225921
44regulation of postsynaptic membrane potential (GO:0060078)3.75472850
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.70634910
46positive regulation of membrane potential (GO:0045838)3.69217043
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.68375131
48regulation of neuronal synaptic plasticity (GO:0048168)3.66177675
49nucleobase catabolic process (GO:0046113)3.63102627
50striatum development (GO:0021756)3.62080197
51neuron recognition (GO:0008038)3.62073886
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61823028
53cerebellar Purkinje cell differentiation (GO:0021702)3.60977042
54auditory behavior (GO:0031223)3.58069091
55long-term memory (GO:0007616)3.55798467
56regulation of synapse structural plasticity (GO:0051823)3.52756400
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50195588
58neurotransmitter transport (GO:0006836)3.48573391
59behavioral response to cocaine (GO:0048148)3.47103816
60mechanosensory behavior (GO:0007638)3.46399059
61transmission of nerve impulse (GO:0019226)3.46283739
62positive regulation of synapse assembly (GO:0051965)3.45146363
63positive regulation of synapse maturation (GO:0090129)3.43847399
64membrane hyperpolarization (GO:0060081)3.42063072
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.39039702
66regulation of synaptic plasticity (GO:0048167)3.36327562
67regulation of glutamate secretion (GO:0014048)3.35024254
68membrane depolarization (GO:0051899)3.28503415
69regulation of neurotransmitter secretion (GO:0046928)3.27859188
70regulation of synaptic transmission, GABAergic (GO:0032228)3.27392297
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26520176
72C4-dicarboxylate transport (GO:0015740)3.25766764
73neurotransmitter uptake (GO:0001504)3.25680554
74regulation of neurotransmitter levels (GO:0001505)3.25450045
75response to auditory stimulus (GO:0010996)3.24559238
76negative regulation of dendrite morphogenesis (GO:0050774)3.23391338
77prepulse inhibition (GO:0060134)3.22663093
78positive regulation of neurotransmitter transport (GO:0051590)3.21853051
79proline transport (GO:0015824)3.21480617
80axonal fasciculation (GO:0007413)3.20844050
81neuromuscular process controlling posture (GO:0050884)3.20462806
82potassium ion homeostasis (GO:0055075)3.20048162
83synapse assembly (GO:0007416)3.18458871
84positive regulation of synaptic transmission (GO:0050806)3.18409612
85positive regulation of neurotransmitter secretion (GO:0001956)3.14814879
86membrane depolarization during action potential (GO:0086010)3.14003803
87behavioral defense response (GO:0002209)3.12639037
88behavioral fear response (GO:0001662)3.12639037
89regulation of neurotransmitter transport (GO:0051588)3.12560299
90learning (GO:0007612)3.11466518
91dendritic spine morphogenesis (GO:0060997)3.11020660
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10764601
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10179950
94synaptic transmission (GO:0007268)3.08987210
95cell communication by electrical coupling (GO:0010644)3.08338962
96negative regulation of dendrite development (GO:2000171)3.07804160
97synaptic vesicle endocytosis (GO:0048488)3.04597127
98regulation of synapse maturation (GO:0090128)3.04508437
99ATP hydrolysis coupled proton transport (GO:0015991)3.04141084
100energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.04141084
101potassium ion import (GO:0010107)3.03235205
102L-amino acid import (GO:0043092)3.02795890
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.97331144
104regulation of synaptic transmission (GO:0050804)2.97066271
105serotonin metabolic process (GO:0042428)2.96842962
106regulation of dendritic spine morphogenesis (GO:0061001)2.96513187
107regulation of female receptivity (GO:0045924)2.95001447
108transferrin transport (GO:0033572)2.94147253
109fear response (GO:0042596)2.92463989
110female mating behavior (GO:0060180)2.92290669
111activation of protein kinase A activity (GO:0034199)2.92002951
112regulation of respiratory system process (GO:0044065)2.91763368
113detection of calcium ion (GO:0005513)2.91724857
114positive regulation of dendritic spine development (GO:0060999)2.91670565
115regulation of vesicle fusion (GO:0031338)2.91061447
116regulation of dendritic spine development (GO:0060998)2.90376446
117retinal cone cell development (GO:0046549)2.89503059
118cerebral cortex radially oriented cell migration (GO:0021799)2.88882644
119layer formation in cerebral cortex (GO:0021819)2.87184034
120regulation of voltage-gated calcium channel activity (GO:1901385)2.81838907
121negative regulation of neurotransmitter transport (GO:0051589)2.81143626
122cerebellar Purkinje cell layer development (GO:0021680)2.78142672
123cellular sodium ion homeostasis (GO:0006883)2.77576253
124neuronal action potential (GO:0019228)2.75628607
125retinal ganglion cell axon guidance (GO:0031290)2.74926536
126regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74108808
127regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.73725984
128righting reflex (GO:0060013)2.70917660
129cell communication involved in cardiac conduction (GO:0086065)2.70903088
130negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.70328173
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70153995
132regulation of cardiac muscle cell contraction (GO:0086004)2.67609186
133synapse organization (GO:0050808)2.67398599
134central nervous system projection neuron axonogenesis (GO:0021952)2.65301961
135membrane assembly (GO:0071709)2.64685678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39797152
2GBX2_23144817_ChIP-Seq_PC3_Human4.42688271
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05659642
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96347640
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93283271
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54720839
7TAF15_26573619_Chip-Seq_HEK293_Human2.52038355
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.49881766
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48030266
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48030266
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.47059923
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46301975
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43403390
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41536614
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39950791
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.30882418
17* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26721462
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26199068
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25769222
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20349161
21* RARB_27405468_Chip-Seq_BRAIN_Mouse2.11957148
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02089073
23DROSHA_22980978_ChIP-Seq_HELA_Human2.01347196
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99869002
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.99757986
26AR_21572438_ChIP-Seq_LNCaP_Human1.99205430
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.98604548
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98426385
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.97267423
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96076195
31SMAD4_21799915_ChIP-Seq_A2780_Human1.92343770
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89416016
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89203032
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88519428
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87240660
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86954844
37P300_19829295_ChIP-Seq_ESCs_Human1.82664304
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69655588
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68632248
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68363216
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.64213900
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63321304
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.59104170
44FUS_26573619_Chip-Seq_HEK293_Human1.55901552
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.50956533
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50010829
47EWS_26573619_Chip-Seq_HEK293_Human1.49188289
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.47718524
49RNF2_27304074_Chip-Seq_NSC_Mouse1.47718112
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46803053
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45208636
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42885762
53* AR_25329375_ChIP-Seq_VCAP_Human1.42771742
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.40641452
55STAT3_23295773_ChIP-Seq_U87_Human1.39753297
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38898782
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38447610
58IGF1R_20145208_ChIP-Seq_DFB_Human1.37408479
59ZNF274_21170338_ChIP-Seq_K562_Hela1.35891039
60ER_23166858_ChIP-Seq_MCF-7_Human1.30189374
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29509432
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29084573
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27039451
64* TCF4_23295773_ChIP-Seq_U87_Human1.25713007
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23940509
66RUNX2_22187159_ChIP-Seq_PCA_Human1.21823437
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21626958
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21559443
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21221824
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20724406
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19742390
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.19299095
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18967329
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.18087073
75CBP_20019798_ChIP-Seq_JUKART_Human1.17901287
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17901287
77VDR_22108803_ChIP-Seq_LS180_Human1.16585298
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.16265895
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15712432
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.15707251
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.15538858
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15312769
83SOX9_26525672_Chip-Seq_HEART_Mouse1.14907573
84AR_19668381_ChIP-Seq_PC3_Human1.14429562
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11851757
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11280000
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11104318
88AHR_22903824_ChIP-Seq_MCF-7_Human1.10700234
89* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10418244
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10293267
91* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10264648
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08546059
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.07662637
94JUN_21703547_ChIP-Seq_K562_Human1.07233129
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.06147411
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05093906
97TCF4_22108803_ChIP-Seq_LS180_Human1.05014126
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04501562
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03967624
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03967624
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03615933
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03547992
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03149917
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.02522808
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01848561
106TP53_16413492_ChIP-PET_HCT116_Human1.01653430
107BCAT_22108803_ChIP-Seq_LS180_Human1.01526814
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01512313
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.00876584
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00104128
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99285702
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98809382
113P53_22387025_ChIP-Seq_ESCs_Mouse0.97685369
114TP53_18474530_ChIP-ChIP_U2OS_Human0.97682284
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97469488
116KDM2B_26808549_Chip-Seq_REH_Human0.95876802
117* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95560059
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95487474
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.93692321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18919930
2MP0003880_abnormal_central_pattern5.09522294
3MP0003635_abnormal_synaptic_transmissio3.94093523
4MP0009046_muscle_twitch3.70251472
5MP0009745_abnormal_behavioral_response3.57105306
6MP0002064_seizures3.30180104
7MP0001968_abnormal_touch/_nociception3.29123799
8MP0002063_abnormal_learning/memory/cond3.20229210
9MP0004270_analgesia3.17628445
10MP0002822_catalepsy3.13770176
11MP0002572_abnormal_emotion/affect_behav2.98679633
12MP0002736_abnormal_nociception_after2.90645138
13MP0002272_abnormal_nervous_system2.74123959
14MP0001486_abnormal_startle_reflex2.70491178
15MP0002734_abnormal_mechanical_nocicepti2.61440346
16MP0005423_abnormal_somatic_nervous2.60595360
17MP0001501_abnormal_sleep_pattern2.38205611
18MP0005646_abnormal_pituitary_gland2.28281660
19MP0002735_abnormal_chemical_nociception2.25994933
20MP0001440_abnormal_grooming_behavior2.22391726
21MP0002067_abnormal_sensory_capabilities2.21641975
22MP0001529_abnormal_vocalization2.15655006
23MP0002733_abnormal_thermal_nociception1.96046214
24MP0001970_abnormal_pain_threshold1.93957486
25MP0001984_abnormal_olfaction1.93391757
26MP0006276_abnormal_autonomic_nervous1.91267168
27MP0000569_abnormal_digit_pigmentation1.89517096
28MP0001188_hyperpigmentation1.87593760
29MP0005386_behavior/neurological_phenoty1.85539239
30MP0004924_abnormal_behavior1.85539239
31MP0002184_abnormal_innervation1.84457630
32MP0003787_abnormal_imprinting1.84326512
33MP0008569_lethality_at_weaning1.82598466
34MP0009780_abnormal_chondrocyte_physiolo1.80129917
35MP0002557_abnormal_social/conspecific_i1.78316083
36MP0003879_abnormal_hair_cell1.78138430
37MP0004142_abnormal_muscle_tone1.73287231
38MP0003122_maternal_imprinting1.68876072
39MP0000778_abnormal_nervous_system1.64351571
40MP0005645_abnormal_hypothalamus_physiol1.58572779
41MP0003123_paternal_imprinting1.48819753
42MP0004811_abnormal_neuron_physiology1.43947423
43MP0002066_abnormal_motor_capabilities/c1.38803281
44MP0000955_abnormal_spinal_cord1.34163079
45MP0002882_abnormal_neuron_morphology1.32099490
46MP0001905_abnormal_dopamine_level1.30625116
47MP0005253_abnormal_eye_physiology1.28386839
48MP0003195_calcinosis1.27952303
49MP0006072_abnormal_retinal_apoptosis1.27175789
50MP0001502_abnormal_circadian_rhythm1.25768268
51MP0002876_abnormal_thyroid_physiology1.23976931
52MP0003283_abnormal_digestive_organ1.19815168
53MP0004858_abnormal_nervous_system1.16467350
54MP0004742_abnormal_vestibular_system1.16221766
55MP0000751_myopathy1.13414948
56MP0002837_dystrophic_cardiac_calcinosis1.12234263
57MP0004133_heterotaxia1.10139250
58MP0003633_abnormal_nervous_system1.09721796
59MP0002909_abnormal_adrenal_gland1.06252839
60MP0008872_abnormal_physiological_respon1.05496187
61MP0003329_amyloid_beta_deposits1.01644022
62MP0002152_abnormal_brain_morphology1.00219244
63MP0003631_nervous_system_phenotype0.99093445
64MP0005171_absent_coat_pigmentation0.98683412
65MP0004145_abnormal_muscle_electrophysio0.97774569
66MP0000516_abnormal_urinary_system0.96038832
67MP0005367_renal/urinary_system_phenotyp0.96038832
68MP0004885_abnormal_endolymph0.95100111
69MP0001963_abnormal_hearing_physiology0.95050032
70MP0005551_abnormal_eye_electrophysiolog0.94830742
71MP0004085_abnormal_heartbeat0.92600936
72MP0002069_abnormal_eating/drinking_beha0.92432734
73MP0002234_abnormal_pharynx_morphology0.90807939
74MP0000631_abnormal_neuroendocrine_gland0.90611931
75MP0000566_synostosis0.90333022
76MP0003183_abnormal_peptide_metabolism0.88894257
77MP0005248_abnormal_Harderian_gland0.88446010
78MP0010386_abnormal_urinary_bladder0.87889415
79MP0002229_neurodegeneration0.87245411
80MP0004215_abnormal_myocardial_fiber0.86712826
81MP0003011_delayed_dark_adaptation0.85626060
82MP0001177_atelectasis0.83461860
83MP0004043_abnormal_pH_regulation0.83345410
84MP0008874_decreased_physiological_sensi0.82872107
85MP0005187_abnormal_penis_morphology0.82562702
86MP0005499_abnormal_olfactory_system0.79317561
87MP0005394_taste/olfaction_phenotype0.79317561
88MP0001485_abnormal_pinna_reflex0.78657900
89MP0002752_abnormal_somatic_nervous0.77818352
90MP0003121_genomic_imprinting0.75225188
91MP0004484_altered_response_of0.74549299
92MP0003646_muscle_fatigue0.74314682
93MP0003632_abnormal_nervous_system0.73721198
94MP0003868_abnormal_feces_composition0.73261288
95MP0005409_darkened_coat_color0.72951726
96MP0000013_abnormal_adipose_tissue0.72683918
97MP0003137_abnormal_impulse_conducting0.72642460
98MP0002928_abnormal_bile_duct0.70105114
99MP0005535_abnormal_body_temperature0.69946470
100MP0002751_abnormal_autonomic_nervous0.68885922
101MP0001664_abnormal_digestion0.65824236
102MP0000534_abnormal_ureter_morphology0.65382302
103MP0000026_abnormal_inner_ear0.65216774
104MP0003634_abnormal_glial_cell0.64255547
105MP0002090_abnormal_vision0.63867873
106MP0001986_abnormal_taste_sensitivity0.63605702
107MP0001943_abnormal_respiration0.63009677
108MP0002102_abnormal_ear_morphology0.57455034
109MP0002638_abnormal_pupillary_reflex0.56398903
110MP0008877_abnormal_DNA_methylation0.55718765
111MP0008004_abnormal_stomach_pH0.55708982
112MP0000920_abnormal_myelination0.55506061
113MP0010770_preweaning_lethality0.54761885
114MP0002082_postnatal_lethality0.54761885
115MP0003690_abnormal_glial_cell0.53834852
116MP0010769_abnormal_survival0.52239653
117MP0004233_abnormal_muscle_weight0.51472598
118MP0010768_mortality/aging0.49629895
119MP0005379_endocrine/exocrine_gland_phen0.46444427
120MP0003956_abnormal_body_size0.46044694

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.76373593
2Atonic seizures (HP:0010819)5.80283114
3Myokymia (HP:0002411)5.79357874
4Focal seizures (HP:0007359)5.75996476
5Febrile seizures (HP:0002373)5.64130524
6Epileptic encephalopathy (HP:0200134)5.51575567
7Hyperventilation (HP:0002883)4.71101086
8Absence seizures (HP:0002121)4.53469354
9Progressive cerebellar ataxia (HP:0002073)4.40771513
10Visual hallucinations (HP:0002367)4.17202454
11Dialeptic seizures (HP:0011146)4.13085898
12Broad-based gait (HP:0002136)4.09144397
13Gaze-evoked nystagmus (HP:0000640)3.93772176
14Generalized tonic-clonic seizures (HP:0002069)3.89859715
15Action tremor (HP:0002345)3.22796593
16Abnormal eating behavior (HP:0100738)3.21517425
17Hypoglycemic seizures (HP:0002173)3.13466896
18Dysdiadochokinesis (HP:0002075)3.12139851
19Abnormal hair whorl (HP:0010721)3.08326466
20Impaired vibration sensation in the lower limbs (HP:0002166)2.95885511
21Poor eye contact (HP:0000817)2.94755959
22Truncal ataxia (HP:0002078)2.91599499
23Polyphagia (HP:0002591)2.90569506
24Gait imbalance (HP:0002141)2.86561807
25Excessive salivation (HP:0003781)2.79486482
26Drooling (HP:0002307)2.79486482
27Epileptiform EEG discharges (HP:0011182)2.74185212
28True hermaphroditism (HP:0010459)2.69364389
29Hyperinsulinemic hypoglycemia (HP:0000825)2.68909290
30Dysmetric saccades (HP:0000641)2.67396228
31Protruding tongue (HP:0010808)2.67103582
32Impaired social interactions (HP:0000735)2.66639665
33Abnormal social behavior (HP:0012433)2.66639665
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.65564437
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.65564437
36Anxiety (HP:0000739)2.64907308
37Hypoglycemic coma (HP:0001325)2.64822908
38Scanning speech (HP:0002168)2.61769669
39Dysmetria (HP:0001310)2.61168911
40Amblyopia (HP:0000646)2.59577748
41Fetal akinesia sequence (HP:0001989)2.58526306
42Congenital primary aphakia (HP:0007707)2.58114163
43Blue irides (HP:0000635)2.56422453
44Absent speech (HP:0001344)2.54381767
45Progressive inability to walk (HP:0002505)2.53900132
46Medial flaring of the eyebrow (HP:0010747)2.52279082
47Depression (HP:0000716)2.50993776
48Urinary bladder sphincter dysfunction (HP:0002839)2.50390119
49Limb dystonia (HP:0002451)2.49962269
50Nephrogenic diabetes insipidus (HP:0009806)2.47194873
51EEG with generalized epileptiform discharges (HP:0011198)2.46762191
52Impaired smooth pursuit (HP:0007772)2.38818723
53Pheochromocytoma (HP:0002666)2.38121240
54Pancreatic fibrosis (HP:0100732)2.38087069
55Peripheral hypomyelination (HP:0007182)2.36734396
56Genetic anticipation (HP:0003743)2.36247582
57Ankle clonus (HP:0011448)2.35317890
58Poor suck (HP:0002033)2.33168209
59Ulnar claw (HP:0001178)2.32976247
60Hepatoblastoma (HP:0002884)2.32040924
61Hypsarrhythmia (HP:0002521)2.31985246
62Molar tooth sign on MRI (HP:0002419)2.30774339
63Abnormality of midbrain morphology (HP:0002418)2.30774339
64Diplopia (HP:0000651)2.30611407
65Abnormality of binocular vision (HP:0011514)2.30611407
66Postural instability (HP:0002172)2.30606531
67Specific learning disability (HP:0001328)2.28729601
68Failure to thrive in infancy (HP:0001531)2.28019256
69Abnormality of the labia minora (HP:0012880)2.27535538
70Narrow nasal bridge (HP:0000446)2.26973496
71Torticollis (HP:0000473)2.26891668
72Hypothermia (HP:0002045)2.26115682
73Status epilepticus (HP:0002133)2.25893687
74Inability to walk (HP:0002540)2.24704556
75Hemiparesis (HP:0001269)2.23095385
76Resting tremor (HP:0002322)2.22818381
77Impaired vibratory sensation (HP:0002495)2.19182948
78Focal dystonia (HP:0004373)2.18838420
79Pancreatic cysts (HP:0001737)2.15150939
80Bradykinesia (HP:0002067)2.14269377
81Stereotypic behavior (HP:0000733)2.13635130
82Abnormality of ocular smooth pursuit (HP:0000617)2.12681179
83Neuroendocrine neoplasm (HP:0100634)2.09925927
84Spastic gait (HP:0002064)2.08485966
85Incomplete penetrance (HP:0003829)2.06310381
86Nephronophthisis (HP:0000090)2.04900952
87Split foot (HP:0001839)2.01521617
88Acute necrotizing encephalopathy (HP:0006965)2.01327397
89Genital tract atresia (HP:0001827)1.99967442
90Generalized myoclonic seizures (HP:0002123)1.99842154
91Abnormality of the corticospinal tract (HP:0002492)1.99129621
92Urinary urgency (HP:0000012)1.97729427
93Mutism (HP:0002300)1.96908550
94Abnormal mitochondria in muscle tissue (HP:0008316)1.96268003
95Vaginal atresia (HP:0000148)1.95897137
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.95383525
97Absent/shortened dynein arms (HP:0200106)1.95383525
98Craniofacial dystonia (HP:0012179)1.94684940
99Poor coordination (HP:0002370)1.94327099
100Abnormality of salivation (HP:0100755)1.93503587
101Hyperthyroidism (HP:0000836)1.92421804
102Increased circulating renin level (HP:0000848)1.91570762
103Hemiplegia (HP:0002301)1.91407880
104Gait ataxia (HP:0002066)1.91193565
105Progressive macrocephaly (HP:0004481)1.89756191
106Sensory axonal neuropathy (HP:0003390)1.88853102
107Morphological abnormality of the pyramidal tract (HP:0002062)1.88520460
108Optic nerve hypoplasia (HP:0000609)1.87092737
109Esotropia (HP:0000565)1.86770933
110Abnormality of the renal medulla (HP:0100957)1.85289404
111Oligomenorrhea (HP:0000876)1.85150522
112Fair hair (HP:0002286)1.84322797
113Sleep apnea (HP:0010535)1.82651371
114Narrow forehead (HP:0000341)1.81832432
115Polydipsia (HP:0001959)1.81653516
116Abnormal drinking behavior (HP:0030082)1.81653516
117Methylmalonic acidemia (HP:0002912)1.81648557
118Generalized hypopigmentation of hair (HP:0011358)1.81637250
119Hypoventilation (HP:0002791)1.80706869
120Megalencephaly (HP:0001355)1.78964252
121Broad foot (HP:0001769)1.78565572
122Supranuclear gaze palsy (HP:0000605)1.78408761
123Pachygyria (HP:0001302)1.78154985
124Abnormality of the lower motor neuron (HP:0002366)1.76904774
125Large for gestational age (HP:0001520)1.76715811
126Annular pancreas (HP:0001734)1.76359720
127Insidious onset (HP:0003587)1.76056847
128Termporal pattern (HP:0011008)1.76056847
129Septo-optic dysplasia (HP:0100842)1.71783179
130Ketoacidosis (HP:0001993)1.71696529
131Epidermoid cyst (HP:0200040)1.70707814
132Postaxial hand polydactyly (HP:0001162)1.70575467
133Renal cortical cysts (HP:0000803)1.69615434
134Aplasia/Hypoplasia of the lens (HP:0008063)1.66819329
135Muscular hypotonia of the trunk (HP:0008936)1.65523825
136Exotropia (HP:0000577)1.65499335
137Left ventricular hypertrophy (HP:0001712)1.64935267
138Akinesia (HP:0002304)1.62974278
139Cystic liver disease (HP:0006706)1.62894231
140Abnormality of the metopic suture (HP:0005556)1.62717609
141Intestinal atresia (HP:0011100)1.62698777
142Gastroesophageal reflux (HP:0002020)1.61986364
143Neoplasm of the adrenal cortex (HP:0100641)1.60833194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.07418239
2NTRK34.52566256
3EPHA43.59064949
4MAP3K43.27021300
5MAP2K73.17553977
6FRK3.01907931
7MAP3K122.90934509
8MAP3K92.62675714
9MARK12.31058001
10TNIK2.24692940
11PRPF4B2.14440145
12DAPK22.13014164
13CDK192.09402436
14NTRK22.02140647
15MINK12.00379107
16MAP2K41.90251750
17PLK21.87719216
18AKT31.80620213
19MAP4K21.76473926
20MAPK131.75351560
21DAPK11.69792453
22CSNK1G31.63523238
23SIK31.58202559
24RIPK41.56762591
25FGFR21.52196094
26CSNK1G11.51704783
27MKNK21.45702861
28OXSR11.40372028
29SGK21.35596751
30PAK61.30779919
31CDK51.29856050
32PRKCG1.26796578
33SGK2231.25963757
34SGK4941.25963757
35DYRK21.25949554
36CAMKK21.25173518
37FES1.23294170
38GRK51.21058465
39CCNB11.21004575
40ARAF1.15167579
41KSR11.13454679
42CAMK2A1.11534414
43CSNK1A1L1.11457874
44BMPR1B1.08879461
45CAMKK11.08571213
46SIK21.04179035
47TSSK61.03549586
48BMPR21.03063517
49LIMK10.96965581
50CAMK2B0.96934735
51PNCK0.91571981
52OBSCN0.91473953
53KSR20.85273331
54SGK30.82980601
55NTRK10.82780782
56RPS6KA40.82516768
57MAP3K130.79086501
58CDK180.78553508
59WNK30.78273882
60MUSK0.78078574
61STK380.78065493
62NEK60.77406601
63BRAF0.77212714
64ADRBK20.77134368
65PRKCE0.76151706
66UHMK10.75503429
67PHKG20.73696976
68PHKG10.73696976
69SGK10.73608730
70CDK150.71446062
71CAMK10.71207146
72BCR0.70380631
73STK38L0.69992123
74CDK140.67743870
75PTK2B0.67135905
76TYRO30.66072065
77STK160.65517920
78PRKD30.65338105
79PRKCZ0.64654637
80PRKCH0.64055619
81TNK20.62554967
82STK110.59792207
83DYRK1A0.58902592
84CDK11A0.58448152
85CAMK2D0.58104563
86PASK0.57969232
87EPHA30.57018011
88MAPK150.56544240
89GRK10.56037687
90CAMK2G0.55827269
91CDK80.54550331
92CSNK1A10.52195919
93NME10.52189994
94MARK20.51127555
95ERBB40.50863581
96LATS20.50797429
97CDK30.50205021
98INSRR0.49357265
99PKN10.48847735
100DYRK30.48462310
101MKNK10.47849979
102GRK70.47369935
103WNK10.45774367
104PINK10.45736253
105STK390.45552981
106CSNK1D0.45274153
107TAOK10.45120080
108FGFR30.44895338
109CAMK40.44866555
110RPS6KA30.43530509
111CSNK1E0.42130035
112ADRBK10.41936666
113CSNK1G20.41601460
114MAP3K60.41447921
115PDK10.40874674
116PRKAA10.40180923
117PDK40.40089892
118PDK30.40089892
119CAMK1G0.39758476
120PDPK10.39740057
121PRKACA0.39442362
122FGR0.38447859
123CDC42BPA0.38421413
124PIK3CA0.37957416
125ROCK20.37939162
126FER0.37867835
127PRKG10.37701187
128RET0.37683720
129PAK30.36664576
130PRKCB0.36550828
131ERBB30.36458979
132MAPK100.35859398
133DAPK30.35708314
134PRKCA0.34064265
135ROCK10.33320160
136ERBB20.32661128
137WNK40.26983166
138PRKACB0.25959505

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.55244382
2Synaptic vesicle cycle_Homo sapiens_hsa047213.66462346
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.99139709
4GABAergic synapse_Homo sapiens_hsa047272.91249089
5Morphine addiction_Homo sapiens_hsa050322.87145657
6Olfactory transduction_Homo sapiens_hsa047402.73782357
7Circadian entrainment_Homo sapiens_hsa047132.69593429
8Collecting duct acid secretion_Homo sapiens_hsa049662.64738533
9Glutamatergic synapse_Homo sapiens_hsa047242.57091359
10Amphetamine addiction_Homo sapiens_hsa050312.48596082
11Long-term potentiation_Homo sapiens_hsa047202.43848162
12Dopaminergic synapse_Homo sapiens_hsa047282.17168558
13Taste transduction_Homo sapiens_hsa047422.16446601
14Salivary secretion_Homo sapiens_hsa049702.03063453
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.97028137
16Insulin secretion_Homo sapiens_hsa049111.90736932
17Serotonergic synapse_Homo sapiens_hsa047261.87650584
18Long-term depression_Homo sapiens_hsa047301.86061019
19Cocaine addiction_Homo sapiens_hsa050301.75627460
20Cholinergic synapse_Homo sapiens_hsa047251.74687003
21Calcium signaling pathway_Homo sapiens_hsa040201.70864765
22Renin secretion_Homo sapiens_hsa049241.69117496
23Protein export_Homo sapiens_hsa030601.63851501
24Gastric acid secretion_Homo sapiens_hsa049711.62140577
25Vibrio cholerae infection_Homo sapiens_hsa051101.60783952
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59170409
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58048890
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51551101
29Oxytocin signaling pathway_Homo sapiens_hsa049211.49882986
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45921705
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43891297
32Steroid biosynthesis_Homo sapiens_hsa001001.37050601
33Oxidative phosphorylation_Homo sapiens_hsa001901.36358437
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24513929
35Propanoate metabolism_Homo sapiens_hsa006401.22221109
36Gap junction_Homo sapiens_hsa045401.21554606
37cAMP signaling pathway_Homo sapiens_hsa040241.20343800
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18999747
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17425925
40Cardiac muscle contraction_Homo sapiens_hsa042601.16205914
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14007353
42GnRH signaling pathway_Homo sapiens_hsa049121.13420133
43Axon guidance_Homo sapiens_hsa043601.05650437
44Regulation of autophagy_Homo sapiens_hsa041400.99516268
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98269927
46Phototransduction_Homo sapiens_hsa047440.97686519
47Type II diabetes mellitus_Homo sapiens_hsa049300.97257296
48Alzheimers disease_Homo sapiens_hsa050100.95845248
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94339199
50ErbB signaling pathway_Homo sapiens_hsa040120.93749419
51Parkinsons disease_Homo sapiens_hsa050120.92966008
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92718995
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91379839
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91136910
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.90275254
56Estrogen signaling pathway_Homo sapiens_hsa049150.89492287
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.89002247
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88630530
59Nitrogen metabolism_Homo sapiens_hsa009100.85886420
60Ether lipid metabolism_Homo sapiens_hsa005650.85483099
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83192225
62Melanogenesis_Homo sapiens_hsa049160.81182359
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81003196
64Fatty acid biosynthesis_Homo sapiens_hsa000610.80979387
65Rheumatoid arthritis_Homo sapiens_hsa053230.80823101
66Fatty acid metabolism_Homo sapiens_hsa012120.78670832
67Type I diabetes mellitus_Homo sapiens_hsa049400.78169014
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77329899
69Dilated cardiomyopathy_Homo sapiens_hsa054140.76533569
70Bile secretion_Homo sapiens_hsa049760.75260527
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74565812
72Glioma_Homo sapiens_hsa052140.74192056
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71686420
74Peroxisome_Homo sapiens_hsa041460.71125344
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66141705
76Vitamin B6 metabolism_Homo sapiens_hsa007500.65113405
77MAPK signaling pathway_Homo sapiens_hsa040100.64828418
78beta-Alanine metabolism_Homo sapiens_hsa004100.64401349
79Pancreatic secretion_Homo sapiens_hsa049720.63362290
80Huntingtons disease_Homo sapiens_hsa050160.60711549
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60147590
82ABC transporters_Homo sapiens_hsa020100.58455441
83Circadian rhythm_Homo sapiens_hsa047100.58042975
84Thyroid hormone synthesis_Homo sapiens_hsa049180.57316783
85Oocyte meiosis_Homo sapiens_hsa041140.54105092
86Ras signaling pathway_Homo sapiens_hsa040140.53235189
87Tryptophan metabolism_Homo sapiens_hsa003800.51765375
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51375742
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51299620
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.49265406
91Linoleic acid metabolism_Homo sapiens_hsa005910.47971135
92Alcoholism_Homo sapiens_hsa050340.47787529
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47763728
94Glucagon signaling pathway_Homo sapiens_hsa049220.46938467
95Choline metabolism in cancer_Homo sapiens_hsa052310.46575442
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46534716
97Phagosome_Homo sapiens_hsa041450.46528205
98Ovarian steroidogenesis_Homo sapiens_hsa049130.46222196
99Mineral absorption_Homo sapiens_hsa049780.45730759
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45442173
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44703321
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44677576
103Dorso-ventral axis formation_Homo sapiens_hsa043200.43479887
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41975117
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41133722
106Rap1 signaling pathway_Homo sapiens_hsa040150.39814092
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38973948
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37635285
109Folate biosynthesis_Homo sapiens_hsa007900.37512976
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37157716
111Histidine metabolism_Homo sapiens_hsa003400.36813285
112AMPK signaling pathway_Homo sapiens_hsa041520.36534073
113Inositol phosphate metabolism_Homo sapiens_hsa005620.33903472
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33557905
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33305111
116Arginine and proline metabolism_Homo sapiens_hsa003300.33044884
117Fatty acid elongation_Homo sapiens_hsa000620.32972107
118Butanoate metabolism_Homo sapiens_hsa006500.31313974
119Wnt signaling pathway_Homo sapiens_hsa043100.31165296
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30511831
121African trypanosomiasis_Homo sapiens_hsa051430.30025878
122Melanoma_Homo sapiens_hsa052180.28454794
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.27243868
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27110752
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.25797521
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25360552
127Prion diseases_Homo sapiens_hsa050200.23894177
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20599746
129Insulin signaling pathway_Homo sapiens_hsa049100.20381518
130Renal cell carcinoma_Homo sapiens_hsa052110.20087223
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18970465
132Endometrial cancer_Homo sapiens_hsa052130.18820482

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