LRRIQ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.88397785
2axonemal dynein complex assembly (GO:0070286)9.61411987
3binding of sperm to zona pellucida (GO:0007339)9.44095801
4cell-cell recognition (GO:0009988)9.36903433
5reproduction (GO:0000003)9.33732797
6acrosome reaction (GO:0007340)9.24856552
7epithelial cilium movement (GO:0003351)9.10573542
8male meiosis (GO:0007140)9.03300108
9motile cilium assembly (GO:0044458)8.63958151
10spermatid development (GO:0007286)8.41570019
11synaptonemal complex organization (GO:0070193)7.86544682
12cilium movement (GO:0003341)7.80375224
13synaptonemal complex assembly (GO:0007130)7.70651850
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.68959844
15single fertilization (GO:0007338)7.33254363
16regulation of cilium movement (GO:0003352)6.95707688
17fertilization (GO:0009566)6.38183584
18DNA methylation involved in gamete generation (GO:0043046)6.31561548
19sperm capacitation (GO:0048240)6.09390734
20DNA synthesis involved in DNA repair (GO:0000731)5.77767767
21spermatogenesis (GO:0007283)5.76824345
22male meiosis I (GO:0007141)5.75786911
23male gamete generation (GO:0048232)5.74853008
24resolution of meiotic recombination intermediates (GO:0000712)5.42886203
25gamete generation (GO:0007276)5.41453530
26negative regulation of inclusion body assembly (GO:0090084)5.39923843
27chromosome organization involved in meiosis (GO:0070192)5.32808930
28microtubule depolymerization (GO:0007019)5.30148186
29meiotic nuclear division (GO:0007126)5.17744126
30monoubiquitinated protein deubiquitination (GO:0035520)5.04025156
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.00201817
32microtubule severing (GO:0051013)4.95631960
33germ cell development (GO:0007281)4.90087471
34organic cation transport (GO:0015695)4.84375863
35ventricular system development (GO:0021591)4.72519367
36meiosis I (GO:0007127)4.70204979
37meiotic cell cycle (GO:0051321)4.64788737
38regulation of inclusion body assembly (GO:0090083)4.54600520
39cell recognition (GO:0008037)4.43227493
40spermatid nucleus differentiation (GO:0007289)4.42122404
41calcium ion-dependent exocytosis (GO:0017156)4.32348525
42multicellular organismal reproductive process (GO:0048609)4.24363946
43seminiferous tubule development (GO:0072520)4.18615791
44glycerol ether metabolic process (GO:0006662)4.13002779
45reciprocal meiotic recombination (GO:0007131)4.11341811
46reciprocal DNA recombination (GO:0035825)4.11341811
47regulation of microtubule-based movement (GO:0060632)4.09321186
48meiotic chromosome segregation (GO:0045132)4.06665234
49regulation of meiosis I (GO:0060631)4.06635636
50regulation of mitochondrial translation (GO:0070129)3.95436731
51gene silencing by RNA (GO:0031047)3.87782440
52genitalia morphogenesis (GO:0035112)3.86323032
53protein polyglutamylation (GO:0018095)3.85144374
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.83672385
55ether metabolic process (GO:0018904)3.79266680
56centriole replication (GO:0007099)3.73952758
57CENP-A containing nucleosome assembly (GO:0034080)3.62765667
58protein localization to cilium (GO:0061512)3.62667870
59intraciliary transport (GO:0042073)3.61284812
60rRNA methylation (GO:0031167)3.56328332
61proteasome assembly (GO:0043248)3.54647623
62chromatin remodeling at centromere (GO:0031055)3.54462049
63centriole assembly (GO:0098534)3.53321280
64lactate metabolic process (GO:0006089)3.47493095
65meiotic cell cycle process (GO:1903046)3.40965962
66regulation of DNA endoreduplication (GO:0032875)3.39635988
67protein localization to chromosome (GO:0034502)3.38728377
68protein localization to kinetochore (GO:0034501)3.38217476
69rRNA modification (GO:0000154)3.37786105
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31946464
71left/right pattern formation (GO:0060972)3.31518056
72multicellular organismal development (GO:0007275)3.30451347
73chromosome condensation (GO:0030261)3.25612020
74kinetochore organization (GO:0051383)3.18051263
75protein localization to chromosome, centromeric region (GO:0071459)3.17461440
76mitotic sister chromatid cohesion (GO:0007064)3.14971632
77protein K11-linked deubiquitination (GO:0035871)3.13995165
78chaperone-mediated protein complex assembly (GO:0051131)3.11879008
79alditol metabolic process (GO:0019400)3.11775496
80synapsis (GO:0007129)3.11326236
81attachment of spindle microtubules to kinetochore (GO:0008608)3.10685501
82cilium organization (GO:0044782)3.07631235
83axoneme assembly (GO:0035082)3.06535557
84cilium morphogenesis (GO:0060271)3.05814854
85DNA packaging (GO:0006323)3.04863826
86mitotic metaphase plate congression (GO:0007080)3.04150085
87amino-acid betaine transport (GO:0015838)3.02178146
88carnitine transport (GO:0015879)3.02178146
89regulation of spindle checkpoint (GO:0090231)3.01405777
90polyol catabolic process (GO:0046174)2.98996656
91cilium assembly (GO:0042384)2.96847626
92sister chromatid cohesion (GO:0007062)2.96424475
93microtubule polymerization or depolymerization (GO:0031109)2.96003420
94microtubule-based movement (GO:0007018)2.94914857
95regulation of histone H3-K9 methylation (GO:0051570)2.94216135
96regulation of centriole replication (GO:0046599)2.93458630
97carnitine transmembrane transport (GO:1902603)2.89056676
98glycerol metabolic process (GO:0006071)2.88713220
99reproductive system development (GO:0061458)2.88621889
100peptidyl-glutamic acid modification (GO:0018200)2.85002133
101regulation of double-strand break repair via homologous recombination (GO:0010569)2.84367574
102single strand break repair (GO:0000012)2.84130318
103cellular component assembly involved in morphogenesis (GO:0010927)2.83762856
104female gamete generation (GO:0007292)2.83702444
105telomere maintenance via semi-conservative replication (GO:0032201)2.82296451
106translesion synthesis (GO:0019985)2.81269482
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.79572034
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79572034
109negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.73979358
110regulation of cardioblast proliferation (GO:0003264)2.72489593
111regulation of secondary heart field cardioblast proliferation (GO:0003266)2.72489593
112tongue development (GO:0043586)2.68746198
113nucleoside diphosphate phosphorylation (GO:0006165)2.68254049
114negative regulation of organelle assembly (GO:1902116)2.67939691
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66413085
116ATP synthesis coupled proton transport (GO:0015986)2.66413085
117gene silencing (GO:0016458)2.65773481
118mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65649990
119establishment of nucleus localization (GO:0040023)2.63939463
120regulation of centrosome cycle (GO:0046605)2.63109565
121ribosomal small subunit assembly (GO:0000028)2.62456471
122mitotic chromosome condensation (GO:0007076)2.60823363
123metaphase plate congression (GO:0051310)2.60093900
124histone H4-K12 acetylation (GO:0043983)2.60056398
125DNA alkylation (GO:0006305)2.57298020
126DNA methylation (GO:0006306)2.57298020
127kinetochore assembly (GO:0051382)2.56846216
128DNA replication-independent nucleosome assembly (GO:0006336)2.56227974
129DNA replication-independent nucleosome organization (GO:0034724)2.56227974
130nucleus organization (GO:0006997)2.55830030
131DNA strand elongation involved in DNA replication (GO:0006271)2.55194045
132GTP biosynthetic process (GO:0006183)2.54897749
133regulation of protein polyubiquitination (GO:1902914)2.54124051
134histone H2A acetylation (GO:0043968)2.53166490
135respiratory electron transport chain (GO:0022904)2.52986135
136electron transport chain (GO:0022900)2.52855126
137spindle checkpoint (GO:0031577)2.52492193
138sexual reproduction (GO:0019953)2.52182748
139spindle assembly checkpoint (GO:0071173)2.52157326
140protein complex biogenesis (GO:0070271)2.50057612
141mitotic spindle checkpoint (GO:0071174)2.49073467
142retinal rod cell development (GO:0046548)2.47677026
143mitotic spindle assembly checkpoint (GO:0007094)2.47541455
144respiratory chain complex IV assembly (GO:0008535)2.46790204
145negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.46515995
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46515995
147negative regulation of sister chromatid segregation (GO:0033046)2.46515995
148protein refolding (GO:0042026)2.44675319
149regulation of cilium assembly (GO:1902017)2.44501176
150histone exchange (GO:0043486)2.43921344
151fusion of sperm to egg plasma membrane (GO:0007342)13.5055584
152cilium or flagellum-dependent cell motility (GO:0001539)12.0534496
153cell wall macromolecule metabolic process (GO:0044036)11.4639848
154cell wall macromolecule catabolic process (GO:0016998)11.4639848
155multicellular organism reproduction (GO:0032504)11.2846138
156sperm motility (GO:0030317)11.1886092
157acrosome assembly (GO:0001675)11.0437736
158sperm-egg recognition (GO:0035036)10.5067772
159plasma membrane fusion (GO:0045026)10.1860499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.07620309
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.74837128
3E2F7_22180533_ChIP-Seq_HELA_Human4.20754797
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.81372052
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.74365647
6EZH2_22144423_ChIP-Seq_EOC_Human3.35428159
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06617784
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93053596
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.75454945
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.73321726
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65498698
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.57005189
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.48009798
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34089585
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28489036
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27259542
17* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26149650
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20811334
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16960680
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15335583
21IGF1R_20145208_ChIP-Seq_DFB_Human2.13708383
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.13134555
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11720709
24VDR_22108803_ChIP-Seq_LS180_Human2.09982245
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07136687
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06924331
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98770430
28EWS_26573619_Chip-Seq_HEK293_Human1.96743683
29* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.93193600
30ELK1_19687146_ChIP-ChIP_HELA_Human1.93006053
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.90888886
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.90557744
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88407240
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.86583639
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86059733
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.85137843
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84336813
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80855882
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80740246
40STAT1_17558387_ChIP-Seq_HELA_Human1.75769316
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74716312
42DCP1A_22483619_ChIP-Seq_HELA_Human1.72766892
43ZNF274_21170338_ChIP-Seq_K562_Hela1.71383060
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.70777257
45KDM2B_26808549_Chip-Seq_REH_Human1.70100118
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69654865
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69193578
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.68739988
49* TAF15_26573619_Chip-Seq_HEK293_Human1.66871078
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.65925754
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.64834042
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64093405
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63952072
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.63252080
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60314749
56VDR_23849224_ChIP-Seq_CD4+_Human1.60305679
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59673325
58MYC_18940864_ChIP-ChIP_HL60_Human1.58167003
59* CBX2_27304074_Chip-Seq_ESCs_Mouse1.56474046
60* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56379333
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56007226
62TTF2_22483619_ChIP-Seq_HELA_Human1.53940423
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52895703
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52853391
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49989018
66* NANOG_18555785_Chip-Seq_ESCs_Mouse1.45522649
67* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44434078
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.44323099
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.43656292
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43590664
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.43255281
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42814608
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40949615
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40321107
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39775753
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39667280
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39084000
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37106597
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35191293
80CBP_20019798_ChIP-Seq_JUKART_Human1.34642319
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34642319
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.33275788
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.31892039
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31651938
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31252611
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.30750538
87P300_19829295_ChIP-Seq_ESCs_Human1.30584989
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29999497
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29545284
90RNF2_27304074_Chip-Seq_NSC_Mouse1.29194010
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.28114474
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.27901465
93RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26940542
94FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26706665
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25532152
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25532152
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25515060
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25395272
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24999643
100* P53_22387025_ChIP-Seq_ESCs_Mouse1.24855622
101* CMYC_18555785_Chip-Seq_ESCs_Mouse1.23739242
102SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23301804
103P300_18555785_Chip-Seq_ESCs_Mouse1.23031215
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.22838443
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22209476
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21260149
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20133465
108LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19403986
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18768208
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18628285
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18131184
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18066388
113GABP_19822575_ChIP-Seq_HepG2_Human1.17925985
114* STAT3_18555785_Chip-Seq_ESCs_Mouse1.16711716
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15848736
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14295412
117GF1_26923725_Chip-Seq_HPCs_Mouse1.14209899
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13668480
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13203316
120SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13106082
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12974009
122MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12726866
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.12411865
124POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12011382
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11477573
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10977321
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.10178386
128ERG_20517297_ChIP-Seq_VCAP_Human1.09897440
129P53_21459846_ChIP-Seq_SAOS-2_Human1.09801788
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.09416815
131* BCAT_22108803_ChIP-Seq_LS180_Human1.09328015
132E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08284955
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.06931969
134AR_21909140_ChIP-Seq_LNCAP_Human1.06426390
135RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05511155
136GF1B_26923725_Chip-Seq_HPCs_Mouse1.04569029
137PU1_27457419_Chip-Seq_LIVER_Mouse1.03721473
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.03370753
139FUS_26573619_Chip-Seq_HEK293_Human1.03229921
140NMYC_18555785_Chip-Seq_ESCs_Mouse1.02961821
141NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02877353
142FOXP3_21729870_ChIP-Seq_TREG_Human1.02848911
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02466083
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01490872
145ESET_19884257_ChIP-Seq_ESCs_Mouse1.01094677
146ZFX_18555785_Chip-Seq_ESCs_Mouse1.00625449
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00423436
148ER_23166858_ChIP-Seq_MCF-7_Human1.00292001
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.99447421
150ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99414315
151SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99234317
152* XRN2_22483619_ChIP-Seq_HELA_Human0.97440829
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96457463
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96206108
155CDX2_22108803_ChIP-Seq_LS180_Human0.95869240
156FOXA1_25329375_ChIP-Seq_VCAP_Human0.95789936
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95789936
158* STAT3_23295773_ChIP-Seq_U87_Human0.95720113
159TCF4_23295773_ChIP-Seq_U87_Human0.94921986
160SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94818997
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.93396936
162RUNX2_22187159_ChIP-Seq_PCA_Human0.93267623
163SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92961167
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92320710
165EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92029928
166ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91198029
167PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90680829
168SMAD4_21799915_ChIP-Seq_A2780_Human0.90545063
169NOTCH1_21737748_ChIP-Seq_TLL_Human0.90282333
170* NFYB_21822215_ChIP-Seq_K562_Human0.89817816
171FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89282970
172SMAD4_21741376_ChIP-Seq_EPCs_Human0.89201351
173* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88270169
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88196302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.59355340
2MP0001929_abnormal_gametogenesis5.52211980
3MP0008877_abnormal_DNA_methylation5.21173933
4MP0003136_yellow_coat_color4.26896306
5MP0002210_abnormal_sex_determination3.84767200
6MP0002653_abnormal_ependyma_morphology3.81710629
7MP0002161_abnormal_fertility/fecundity3.25583068
8MP0001145_abnormal_male_reproductive3.17348239
9MP0000653_abnormal_sex_gland3.00868028
10MP0000383_abnormal_hair_follicle2.59504039
11MP0002139_abnormal_hepatobiliary_system2.21351342
12MP0009053_abnormal_anal_canal2.10198969
13MP0003646_muscle_fatigue2.00670902
14MP0005410_abnormal_fertilization13.7975462
15MP0002277_abnormal_respiratory_mucosa1.84698841
16MP0005084_abnormal_gallbladder_morpholo1.84270473
17MP0005670_abnormal_white_adipose1.78340497
18MP0002102_abnormal_ear_morphology1.72704990
19MP0002909_abnormal_adrenal_gland1.66566328
20MP0005365_abnormal_bile_salt1.63801956
21MP0005647_abnormal_sex_gland1.55777356
22MP0005451_abnormal_body_composition1.54117350
23MP0010678_abnormal_skin_adnexa1.52236164
24MP0002822_catalepsy1.52216758
25MP0002160_abnormal_reproductive_system1.50163929
26MP0005360_urolithiasis1.49835003
27MP0004957_abnormal_blastocyst_morpholog1.43285966
28MP0008789_abnormal_olfactory_epithelium1.40340968
29MP0008057_abnormal_DNA_replication1.38152864
30MP0004233_abnormal_muscle_weight1.37861563
31MP0002282_abnormal_trachea_morphology1.25357204
32MP0005623_abnormal_meninges_morphology1.24813752
33MP0006035_abnormal_mitochondrial_morpho1.23836330
34MP0001188_hyperpigmentation1.23555314
35MP0008875_abnormal_xenobiotic_pharmacok1.21885629
36MP0008058_abnormal_DNA_repair1.20792814
37MP0010094_abnormal_chromosome_stability1.19540080
38MP0004133_heterotaxia1.18170228
39MP0003699_abnormal_female_reproductive1.15389294
40MP0003123_paternal_imprinting1.14144383
41MP0003718_maternal_effect1.14064217
42MP0001299_abnormal_eye_distance/1.11123403
43MP0001286_abnormal_eye_development1.10499153
44MP0001765_abnormal_ion_homeostasis1.09996724
45MP0001119_abnormal_female_reproductive1.09130761
46MP0003119_abnormal_digestive_system1.07570541
47MP0009379_abnormal_foot_pigmentation1.07370541
48MP0000467_abnormal_esophagus_morphology1.02777987
49MP0001984_abnormal_olfaction1.02336681
50MP0002638_abnormal_pupillary_reflex1.00608127
51MP0001293_anophthalmia1.00182248
52MP0001485_abnormal_pinna_reflex0.99967101
53MP0000350_abnormal_cell_proliferation0.96031452
54MP0003252_abnormal_bile_duct0.95061803
55MP0002697_abnormal_eye_size0.94729275
56MP0005646_abnormal_pituitary_gland0.93787451
57MP0003806_abnormal_nucleotide_metabolis0.93279730
58MP0003941_abnormal_skin_development0.93085843
59MP0003011_delayed_dark_adaptation0.91874476
60MP0009703_decreased_birth_body0.91566069
61MP0003943_abnormal_hepatobiliary_system0.90854809
62MP0005389_reproductive_system_phenotype0.89629618
63MP0002928_abnormal_bile_duct0.88633181
64MP0005174_abnormal_tail_pigmentation0.86726926
65MP0006292_abnormal_olfactory_placode0.86399173
66MP0008932_abnormal_embryonic_tissue0.86375259
67MP0005645_abnormal_hypothalamus_physiol0.84226289
68MP0001502_abnormal_circadian_rhythm0.83546712
69MP0005085_abnormal_gallbladder_physiolo0.83071467
70MP0002938_white_spotting0.82534991
71MP0003950_abnormal_plasma_membrane0.82046374
72MP0008007_abnormal_cellular_replicative0.82024943
73MP0002095_abnormal_skin_pigmentation0.80583451
74MP0008995_early_reproductive_senescence0.78404751
75MP0003121_genomic_imprinting0.77156321
76MP0005409_darkened_coat_color0.75499748
77MP0004142_abnormal_muscle_tone0.75299642
78MP0003186_abnormal_redox_activity0.73928858
79MP0000955_abnormal_spinal_cord0.70651404
80MP0002751_abnormal_autonomic_nervous0.70070288
81MP0005195_abnormal_posterior_eye0.69188573
82MP0005636_abnormal_mineral_homeostasis0.68730141
83MP0002735_abnormal_chemical_nociception0.68719197
84MP0001529_abnormal_vocalization0.68041693
85MP0005395_other_phenotype0.67114083
86MP0000026_abnormal_inner_ear0.66493172
87MP0005379_endocrine/exocrine_gland_phen0.66159954
88MP0000313_abnormal_cell_death0.66119530
89MP0001346_abnormal_lacrimal_gland0.64034507
90MP0005408_hypopigmentation0.61284328
91MP0000427_abnormal_hair_cycle0.59635776
92MP0004019_abnormal_vitamin_homeostasis0.59518354
93MP0001851_eye_inflammation0.59226254
94MP0000462_abnormal_digestive_system0.59079250
95MP0003111_abnormal_nucleus_morphology0.57626562
96MP0004264_abnormal_extraembryonic_tissu0.56487549
97MP0001764_abnormal_homeostasis0.55799209
98MP0009697_abnormal_copulation0.55602931
99MP0010307_abnormal_tumor_latency0.55038104
100MP0000639_abnormal_adrenal_gland0.54728686
101MP0000358_abnormal_cell_content/0.52944895
102MP0006072_abnormal_retinal_apoptosis0.52044621
103MP0005551_abnormal_eye_electrophysiolog0.50220607
104MP0004043_abnormal_pH_regulation0.49818288
105MP0002234_abnormal_pharynx_morphology0.49281798
106MP0002971_abnormal_brown_adipose0.49031650
107MP0003077_abnormal_cell_cycle0.48782085
108MP0009046_muscle_twitch0.48508764
109MP0010329_abnormal_lipoprotein_level0.48380605
110MP0003786_premature_aging0.48362599
111MP0003195_calcinosis0.48071320
112MP0002118_abnormal_lipid_homeostasis0.47547457
113MP0001324_abnormal_eye_pigmentation0.44886722
114MP0002837_dystrophic_cardiac_calcinosis0.44780534
115MP0004036_abnormal_muscle_relaxation0.42293875
116MP0003329_amyloid_beta_deposits0.40135480
117MP0006036_abnormal_mitochondrial_physio0.39697297
118MP0003115_abnormal_respiratory_system0.38907270
119MP0001944_abnormal_pancreas_morphology0.38577831
120MP0005666_abnormal_adipose_tissue0.38531974
121MP0001661_extended_life_span0.36840429
122MP0001730_embryonic_growth_arrest0.36802929
123MP0002269_muscular_atrophy0.36582102
124MP0000609_abnormal_liver_physiology0.36288117
125MP0002693_abnormal_pancreas_physiology0.35504816
126MP0003868_abnormal_feces_composition0.35122280
127MP0005253_abnormal_eye_physiology0.34197614
128MP0002084_abnormal_developmental_patter0.33759996
129MP0003937_abnormal_limbs/digits/tail_de0.32443772
130MP0002168_other_aberrant_phenotype0.30889360
131MP0003693_abnormal_embryo_hatching0.29239359
132MP0001915_intracranial_hemorrhage0.29026659
133MP0005319_abnormal_enzyme/_coenzyme0.28528090
134MP0002295_abnormal_pulmonary_circulatio0.28514676
135MP0001727_abnormal_embryo_implantation0.27424068
136MP0009250_abnormal_appendicular_skeleto0.26603991
137MP0001697_abnormal_embryo_size0.26212865
138MP0000631_abnormal_neuroendocrine_gland0.26037793
139MP0009115_abnormal_fat_cell0.25965106
140MP0000569_abnormal_digit_pigmentation0.25487120
141MP0003861_abnormal_nervous_system0.25368808
142MP0002970_abnormal_white_adipose0.24746630
143MP0002085_abnormal_embryonic_tissue0.24316882
144MP0002078_abnormal_glucose_homeostasis0.23425540
145MP0005391_vision/eye_phenotype0.22736641
146MP0005332_abnormal_amino_acid0.22725210
147MP0003890_abnormal_embryonic-extraembry0.22375879

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34740409
2Abnormal respiratory motile cilium morphology (HP:0005938)8.21556894
3Abnormal respiratory epithelium morphology (HP:0012253)8.21556894
4Chronic bronchitis (HP:0004469)7.92641544
5Rhinitis (HP:0012384)7.73881430
6Abnormal ciliary motility (HP:0012262)7.39684695
7Infertility (HP:0000789)6.23653950
8Nasal polyposis (HP:0100582)5.62643075
9Oligodactyly (hands) (HP:0001180)5.02060517
10Male infertility (HP:0003251)4.55182576
11Bronchiectasis (HP:0002110)4.53322855
12Abnormality of the nasal mucosa (HP:0000433)4.51272253
13Nephronophthisis (HP:0000090)4.35146472
14Bronchitis (HP:0012387)4.31438831
15Oligodactyly (HP:0012165)3.42274302
16Abnormality of the renal medulla (HP:0100957)3.38197572
17Medial flaring of the eyebrow (HP:0010747)3.37696197
18Esophageal atresia (HP:0002032)3.37518808
19Abnormal spermatogenesis (HP:0008669)3.22473380
20Recurrent sinusitis (HP:0011108)3.19663699
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.10031554
22Recurrent otitis media (HP:0000403)3.06606815
23Anophthalmia (HP:0000528)3.04939412
24Tubulointerstitial nephritis (HP:0001970)2.99263393
25Abnormality of midbrain morphology (HP:0002418)2.84179344
26Molar tooth sign on MRI (HP:0002419)2.84179344
27Gastrointestinal atresia (HP:0002589)2.84026015
28Volvulus (HP:0002580)2.80985928
29Sclerocornea (HP:0000647)2.76216538
30Intestinal atresia (HP:0011100)2.73221596
31Azoospermia (HP:0000027)2.62741684
32Abnormality of the duodenum (HP:0002246)2.60388946
33Congenital primary aphakia (HP:0007707)2.52729590
34Gonadotropin excess (HP:0000837)2.51327200
35Gait imbalance (HP:0002141)2.51215610
36Abnormality of the lower motor neuron (HP:0002366)2.49418300
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45411310
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45411310
39Tubular atrophy (HP:0000092)2.40150599
40Scotoma (HP:0000575)2.38315843
41Small intestinal stenosis (HP:0012848)2.37181046
42Duodenal stenosis (HP:0100867)2.37181046
43Tubulointerstitial abnormality (HP:0001969)2.35454960
44Preaxial hand polydactyly (HP:0001177)2.31253046
45Maternal diabetes (HP:0009800)2.29723063
46Anencephaly (HP:0002323)2.27734644
47Congenital malformation of the right heart (HP:0011723)2.27320609
48Double outlet right ventricle (HP:0001719)2.27320609
49Congenital, generalized hypertrichosis (HP:0004540)2.26109483
50Urethral obstruction (HP:0000796)2.25957225
51Papillary thyroid carcinoma (HP:0002895)2.24055410
52Nephrogenic diabetes insipidus (HP:0009806)2.23197130
53Postaxial foot polydactyly (HP:0001830)2.14412485
54Severe visual impairment (HP:0001141)2.07703571
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06245790
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.06245790
57Poor coordination (HP:0002370)2.03745776
58Impulsivity (HP:0100710)2.03116385
59Fibular hypoplasia (HP:0003038)2.02034766
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5585370
61Dynein arm defect of respiratory motile cilia (HP:0012255)11.8789102
62Absent/shortened dynein arms (HP:0200106)11.8789102
63Acute necrotizing encephalopathy (HP:0006965)1.98795705
64Chromsome breakage (HP:0040012)1.97688089
65Abnormality of the renal cortex (HP:0011035)1.97327233
66Optic nerve coloboma (HP:0000588)1.96849200
67Increased hepatocellular lipid droplets (HP:0006565)1.95557689
68Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95390375
69Meckel diverticulum (HP:0002245)1.93730570
70Congenital hepatic fibrosis (HP:0002612)1.93711630
71Acute encephalopathy (HP:0006846)1.93432651
72Abnormality of the preputium (HP:0100587)1.92771382
73Genital tract atresia (HP:0001827)1.92714804
74Abnormal gallbladder physiology (HP:0012438)1.91761764
75Cholecystitis (HP:0001082)1.91761764
76Pancreatic fibrosis (HP:0100732)1.91372837
77Shoulder girdle muscle weakness (HP:0003547)1.91172536
78Recurrent bronchitis (HP:0002837)1.90637023
79Rimmed vacuoles (HP:0003805)1.90422528
80Vaginal atresia (HP:0000148)1.89632803
81Triphalangeal thumb (HP:0001199)1.88908062
82Abnormality of dentin (HP:0010299)1.88022070
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88012789
84Mitochondrial inheritance (HP:0001427)1.87671154
85Septo-optic dysplasia (HP:0100842)1.86443015
86Abnormality of the ileum (HP:0001549)1.86253557
87Stage 5 chronic kidney disease (HP:0003774)1.85704410
88Lipid accumulation in hepatocytes (HP:0006561)1.84461479
89Aplasia/Hypoplasia of the lens (HP:0008063)1.83771224
90Microglossia (HP:0000171)1.82894752
91Cystic liver disease (HP:0006706)1.82652019
92Postaxial hand polydactyly (HP:0001162)1.82575113
93Central scotoma (HP:0000603)1.82456743
94Increased CSF lactate (HP:0002490)1.82109458
95Supernumerary bones of the axial skeleton (HP:0009144)1.82007563
96Abnormal mitochondria in muscle tissue (HP:0008316)1.80682804
97Hepatocellular necrosis (HP:0001404)1.79899293
98Male pseudohermaphroditism (HP:0000037)1.79811969
99Abnormal protein glycosylation (HP:0012346)1.78415003
100Abnormal glycosylation (HP:0012345)1.78415003
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78415003
102Abnormal protein N-linked glycosylation (HP:0012347)1.78415003
103Multicystic kidney dysplasia (HP:0000003)1.78119839
104Supernumerary ribs (HP:0005815)1.76894404
105Abnormality of abdominal situs (HP:0011620)1.76882914
106Abdominal situs inversus (HP:0003363)1.76882914
107Abnormality of chromosome stability (HP:0003220)1.76639171
108Amyotrophic lateral sclerosis (HP:0007354)1.76361104
109Supernumerary spleens (HP:0009799)1.73139663
110Hypoplasia of the uterus (HP:0000013)1.73016191
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.71434143
112Polydipsia (HP:0001959)1.70986004
113Abnormal drinking behavior (HP:0030082)1.70986004
114Tubulointerstitial fibrosis (HP:0005576)1.70034771
115Abnormality of the dental root (HP:0006486)1.69320911
116Taurodontia (HP:0000679)1.69320911
117Abnormality of permanent molar morphology (HP:0011071)1.69320911
118Renal dysplasia (HP:0000110)1.68600178
119Abnormal number of incisors (HP:0011064)1.67560659
120Horizontal nystagmus (HP:0000666)1.67511159
121Upper motor neuron abnormality (HP:0002127)1.67095713
122Short ribs (HP:0000773)1.67086563
123Abnormality of macular pigmentation (HP:0008002)1.66992559
124Abnormality of the dental pulp (HP:0006479)1.66572822
125Heterotopia (HP:0002282)1.65272855
126Impaired proprioception (HP:0010831)1.65139536
127Type I transferrin isoform profile (HP:0003642)1.64452628
128Oculomotor apraxia (HP:0000657)1.56465216
129Abnormality of molar morphology (HP:0011070)1.55778194
130Abnormality of molar (HP:0011077)1.55778194
131Spastic tetraparesis (HP:0001285)1.54192335
132Abnormality of renal excretion (HP:0011036)1.54099227
133True hermaphroditism (HP:0010459)1.53358872
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52740192
135Absent epiphyses (HP:0010577)1.52740192
136Abnormal biliary tract physiology (HP:0012439)1.52226917
137Bile duct proliferation (HP:0001408)1.52226917
138Pancreatic cysts (HP:0001737)1.48315020
139Short thorax (HP:0010306)1.44644265
140Spontaneous abortion (HP:0005268)1.44039321
141Aplasia/Hypoplasia of the fibula (HP:0006492)1.32513984
142Chronic hepatic failure (HP:0100626)1.32483032
143Facial cleft (HP:0002006)1.30367919
144Nephropathy (HP:0000112)1.28368219
145Chronic sinusitis (HP:0011109)1.28359502
146Median cleft lip (HP:0000161)1.28257558
147Breast carcinoma (HP:0003002)1.28070829
148Dyschromatopsia (HP:0007641)1.25596866
149Bell-shaped thorax (HP:0001591)1.24833583
150Decreased central vision (HP:0007663)1.24763368
151Vascular calcification (HP:0004934)1.22783223
152Insulin-resistant diabetes mellitus (HP:0000831)1.21821917
153Abnormal urine output (HP:0012590)1.19833160
154Retinitis pigmentosa (HP:0000510)1.19287325
155Occipital encephalocele (HP:0002085)1.18877288
156Broad foot (HP:0001769)1.18820743
157Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.18478318
158Sloping forehead (HP:0000340)1.18410564
159Cerebellar dysplasia (HP:0007033)1.17694399
160Constricted visual fields (HP:0001133)1.17500263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.77295508
2PDK48.77295508
3PDK25.56902759
4TSSK64.15483893
5PRKD33.87722506
6TESK13.51151428
7VRK12.89895346
8BUB12.84906530
9ICK2.54948480
10WNK42.27882152
11STK392.18607168
12MST42.06917205
13PTK2B1.86830977
14STK38L1.73338476
15ZAK1.73310354
16LATS11.68594236
17PLK41.62480172
18NEK21.62145731
19VRK21.54292316
20NME11.50906120
21PNCK1.45153266
22STK381.39550732
23STK161.34718061
24ACVR1B1.33269171
25NEK11.31523319
26CDK191.29153153
27TTK1.28873432
28STK31.27674822
29NEK91.24073957
30MAPK151.19248258
31TAOK31.18826964
32CDK81.14533866
33BCKDK1.06815160
34TLK11.06793854
35MUSK1.05012687
36MAP3K61.03013565
37CHEK20.99236870
38AKT30.98645384
39PASK0.98583720
40BMX0.97036905
41CDC70.97023524
42TYRO30.95704664
43ERBB40.93214507
44PDK10.88093327
45BRAF0.86384017
46DYRK30.81615712
47WNK10.79741836
48LATS20.77324009
49PRKCI0.77145120
50DYRK1B0.76013189
51PLK30.74925603
52RPS6KA50.73291004
53EEF2K0.66731647
54MAP3K120.66273909
55TAF10.65680984
56BMPR1B0.64052229
57YES10.63989585
58TAOK10.63957245
59PINK10.61878057
60PLK20.61045175
61OXSR10.60552583
62AURKB0.59849346
63CCNB10.58667714
64STK40.54303346
65CHEK10.52940153
66MAPKAPK50.51833653
67SGK20.50521860
68MST1R0.49920945
69MOS0.49761218
70IRAK10.49620524
71CSNK2A20.49306240
72MAPK130.48307515
73WNK30.44229534
74ATM0.44079445
75ADRBK20.43830010
76CDK70.43064018
77CDK30.42563683
78RPS6KB20.41436938
79EIF2AK30.41213687
80PRKAA10.41001023
81PDPK10.39310483
82PLK10.39302243
83CSNK2A10.38463337
84CDK90.38041537
85PIM10.37224182
86CAMK1G0.37150045
87BRSK20.37075107
88STK240.36706179
89GRK10.35638189
90LMTK20.35000642
91ATR0.34852099
92SGK2230.34278735
93SGK4940.34278735
94CSF1R0.34029509
95TESK20.33789608
96SGK10.33440584
97CSNK1E0.32674809
98FGR0.32025472
99NEK60.31992027
100MAP3K40.29552799
101PRKAA20.29211884
102DYRK20.28518605
103MARK20.28192385
104CAMKK20.27799877
105MKNK20.27729497
106ABL20.27677929
107BRSK10.27628960
108PAK60.27198739
109BMPR20.26721587
110NTRK20.25710026
111INSRR0.25553375
112MTOR0.25248347
113EIF2AK10.25074091
114CDK120.24886966
115KSR20.23605729
116MELK0.22697495
117MAP3K90.21254067
118IRAK20.20928415
119PRKD20.20565345
120MAP2K70.17740811
121PAK10.17501300
122MAP2K60.17280410
123EPHA30.17164936
124ARAF0.15307017
125MAPKAPK30.14783021
126MET0.14571136
127CSNK1D0.13541061
128MAP3K50.12361036
129FRK0.12060888
130PRKG10.10355086
131PBK0.09697033
132MAP2K40.08949756
133RPS6KB10.08104382
134CDK10.08049261
135RET0.07615404
136PDGFRB0.07496327
137MAPK100.07246827
138CAMK2A0.06654413
139GSK3B0.05331942
140CDK20.05226792
141STK110.04211188
142PKN10.03954827
143WEE10.03193783
144PAK20.02692808
145STK100.02105950
146MAPK10.01569765
147PRKCZ0.01516927
148PRKCG0.01028530
149NUAK10.00641952
150PRKCQ0.00565864
151AURKA0.00511442

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.34525155
2Pyruvate metabolism_Homo sapiens_hsa006203.87180266
3Propanoate metabolism_Homo sapiens_hsa006403.46837081
4Mismatch repair_Homo sapiens_hsa034303.40817401
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.35633921
6DNA replication_Homo sapiens_hsa030303.20464417
7Basal transcription factors_Homo sapiens_hsa030223.12349022
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92879639
9Linoleic acid metabolism_Homo sapiens_hsa005912.85034530
10Oxidative phosphorylation_Homo sapiens_hsa001902.81392797
11Parkinsons disease_Homo sapiens_hsa050122.80345863
12Selenocompound metabolism_Homo sapiens_hsa004502.78756893
13Nucleotide excision repair_Homo sapiens_hsa034202.69293173
14Ribosome_Homo sapiens_hsa030102.58775499
15Fatty acid biosynthesis_Homo sapiens_hsa000612.47418822
16RNA polymerase_Homo sapiens_hsa030202.45231947
17Sulfur relay system_Homo sapiens_hsa041222.35921689
18Glucagon signaling pathway_Homo sapiens_hsa049222.25108478
19One carbon pool by folate_Homo sapiens_hsa006702.21132336
20Base excision repair_Homo sapiens_hsa034102.09896518
21Dorso-ventral axis formation_Homo sapiens_hsa043201.98376512
22PPAR signaling pathway_Homo sapiens_hsa033201.94707733
23Pentose phosphate pathway_Homo sapiens_hsa000301.93549112
24Proteasome_Homo sapiens_hsa030501.92895417
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92884148
26Fanconi anemia pathway_Homo sapiens_hsa034601.88921713
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81174632
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.80686317
29Glycerolipid metabolism_Homo sapiens_hsa005611.80564669
30Ether lipid metabolism_Homo sapiens_hsa005651.72060113
31Oocyte meiosis_Homo sapiens_hsa041141.69315658
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.67399220
33Pyrimidine metabolism_Homo sapiens_hsa002401.65006548
34Non-homologous end-joining_Homo sapiens_hsa034501.64768712
35Folate biosynthesis_Homo sapiens_hsa007901.64617989
36Fatty acid degradation_Homo sapiens_hsa000711.59640729
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58972892
38Spliceosome_Homo sapiens_hsa030401.55985518
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.54476073
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49532293
41Alzheimers disease_Homo sapiens_hsa050101.42685050
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40591794
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38362852
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.38205084
45Fatty acid metabolism_Homo sapiens_hsa012121.33688016
46Sulfur metabolism_Homo sapiens_hsa009201.33476611
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.31786957
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28597365
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23316964
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20888788
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20771766
52Carbon metabolism_Homo sapiens_hsa012001.17413716
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16220113
54Chemical carcinogenesis_Homo sapiens_hsa052041.15612804
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14723658
56Fat digestion and absorption_Homo sapiens_hsa049751.11090305
57Cardiac muscle contraction_Homo sapiens_hsa042601.10672907
58ABC transporters_Homo sapiens_hsa020101.03685929
59Ovarian steroidogenesis_Homo sapiens_hsa049130.97886329
60Biosynthesis of amino acids_Homo sapiens_hsa012300.96386700
61Cell cycle_Homo sapiens_hsa041100.94404851
62RNA degradation_Homo sapiens_hsa030180.93293770
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91648776
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91329697
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88601109
66Glutathione metabolism_Homo sapiens_hsa004800.87105598
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86572774
68Huntingtons disease_Homo sapiens_hsa050160.85921251
69Complement and coagulation cascades_Homo sapiens_hsa046100.85269309
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84947018
71Hedgehog signaling pathway_Homo sapiens_hsa043400.84509177
72Retinol metabolism_Homo sapiens_hsa008300.83888152
73Alcoholism_Homo sapiens_hsa050340.82381998
74Tryptophan metabolism_Homo sapiens_hsa003800.80825883
75Amphetamine addiction_Homo sapiens_hsa050310.77083278
76Peroxisome_Homo sapiens_hsa041460.76834715
77Fructose and mannose metabolism_Homo sapiens_hsa000510.75468591
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.74325828
79RNA transport_Homo sapiens_hsa030130.73759596
80Nitrogen metabolism_Homo sapiens_hsa009100.73676609
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73307487
82Purine metabolism_Homo sapiens_hsa002300.71722979
83Bile secretion_Homo sapiens_hsa049760.70796236
84Mineral absorption_Homo sapiens_hsa049780.68350613
85Systemic lupus erythematosus_Homo sapiens_hsa053220.66753567
86Histidine metabolism_Homo sapiens_hsa003400.63852322
87mRNA surveillance pathway_Homo sapiens_hsa030150.63088599
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61864714
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61687718
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61362305
91Arachidonic acid metabolism_Homo sapiens_hsa005900.60261345
92Basal cell carcinoma_Homo sapiens_hsa052170.58277322
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57876365
94Olfactory transduction_Homo sapiens_hsa047400.54083336
95Phototransduction_Homo sapiens_hsa047440.52650621
96TGF-beta signaling pathway_Homo sapiens_hsa043500.52607678
97Butanoate metabolism_Homo sapiens_hsa006500.51472242
98Metabolic pathways_Homo sapiens_hsa011000.50812413
99Sphingolipid metabolism_Homo sapiens_hsa006000.48865609
100Regulation of autophagy_Homo sapiens_hsa041400.47866286
101Renin secretion_Homo sapiens_hsa049240.46665544
102Estrogen signaling pathway_Homo sapiens_hsa049150.44784930
103Insulin secretion_Homo sapiens_hsa049110.42986452
104Nicotine addiction_Homo sapiens_hsa050330.41818570
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41696940
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40009242
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39667476
108Circadian rhythm_Homo sapiens_hsa047100.39003221
109p53 signaling pathway_Homo sapiens_hsa041150.38789797
110Homologous recombination_Homo sapiens_hsa034400.37757419
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37502269
112AMPK signaling pathway_Homo sapiens_hsa041520.36755015
113Cocaine addiction_Homo sapiens_hsa050300.36320624
114Antigen processing and presentation_Homo sapiens_hsa046120.35855030
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35422109
116Taste transduction_Homo sapiens_hsa047420.35203084
117Lysine degradation_Homo sapiens_hsa003100.35097208
118Arginine biosynthesis_Homo sapiens_hsa002200.33490198
119Inositol phosphate metabolism_Homo sapiens_hsa005620.33281633
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30588110
121Thyroid hormone synthesis_Homo sapiens_hsa049180.29392654
122beta-Alanine metabolism_Homo sapiens_hsa004100.29222229
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27978753
124N-Glycan biosynthesis_Homo sapiens_hsa005100.27729389
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27079528
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26688546
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26579404
128Steroid biosynthesis_Homo sapiens_hsa001000.25095493
129Fatty acid elongation_Homo sapiens_hsa000620.24434079
130Protein export_Homo sapiens_hsa030600.24397849
131Other glycan degradation_Homo sapiens_hsa005110.24192798
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.23759296
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21734656
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21161065
135VEGF signaling pathway_Homo sapiens_hsa043700.20427720
136Tyrosine metabolism_Homo sapiens_hsa003500.20412206
137Viral carcinogenesis_Homo sapiens_hsa052030.19550277
138Phenylalanine metabolism_Homo sapiens_hsa003600.18544550
139Hippo signaling pathway_Homo sapiens_hsa043900.18505086
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.16811962
141Caffeine metabolism_Homo sapiens_hsa002320.16437937
142Renin-angiotensin system_Homo sapiens_hsa046140.15286550
143Wnt signaling pathway_Homo sapiens_hsa043100.15140264
144Collecting duct acid secretion_Homo sapiens_hsa049660.14938459
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14400108
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14049149
147Epstein-Barr virus infection_Homo sapiens_hsa051690.11335669
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10614998

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