LRRFIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.05009116
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.80534800
3cardiac myofibril assembly (GO:0055003)5.23143612
4muscle filament sliding (GO:0030049)5.15411809
5actin-myosin filament sliding (GO:0033275)5.15411809
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00729764
7myofibril assembly (GO:0030239)4.94519617
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.87410160
9plasma membrane repair (GO:0001778)4.84168642
10regulation of skeletal muscle contraction (GO:0014819)4.39990768
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.38039532
12actin-mediated cell contraction (GO:0070252)4.35537897
13cardiac muscle cell development (GO:0055013)4.32234561
14fatty acid transmembrane transport (GO:1902001)4.09532544
15carnitine shuttle (GO:0006853)4.08058984
16sarcoplasmic reticulum calcium ion transport (GO:0070296)4.04009899
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.00445831
18carnitine transmembrane transport (GO:1902603)3.99743270
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.99555974
20cardiac cell development (GO:0055006)3.98021489
21ventricular cardiac muscle cell action potential (GO:0086005)3.95423765
22cytidine deamination (GO:0009972)3.84234370
23cytidine metabolic process (GO:0046087)3.84234370
24cytidine catabolic process (GO:0006216)3.84234370
25cardiac muscle contraction (GO:0060048)3.81496340
26cell wall macromolecule metabolic process (GO:0044036)3.78806804
27cell wall macromolecule catabolic process (GO:0016998)3.78806804
28carnitine transport (GO:0015879)3.78427026
29amino-acid betaine transport (GO:0015838)3.78427026
30tricarboxylic acid cycle (GO:0006099)3.76661661
31heart process (GO:0003015)3.76397205
32heart contraction (GO:0060047)3.76397205
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.74601452
34cardiac muscle hypertrophy (GO:0003300)3.73856706
35fusion of sperm to egg plasma membrane (GO:0007342)3.70591727
36acrosome assembly (GO:0001675)3.69471115
37regulation of relaxation of muscle (GO:1901077)3.68292888
38actomyosin structure organization (GO:0031032)3.64965804
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.61217622
40sperm motility (GO:0030317)3.56693807
41striated muscle hypertrophy (GO:0014897)3.53478751
42regulation of sequestering of triglyceride (GO:0010889)3.51022251
43desmosome organization (GO:0002934)3.49894707
44negative regulation of protein localization to cell surface (GO:2000009)3.48322684
45response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.47575348
46multicellular organism reproduction (GO:0032504)3.43354930
47actin filament-based movement (GO:0030048)3.42826822
48muscle hypertrophy (GO:0014896)3.38380044
49cardiac muscle tissue morphogenesis (GO:0055008)3.34851444
50regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.33314573
51striated muscle contraction (GO:0006941)3.30876292
52low-density lipoprotein particle clearance (GO:0034383)3.29605607
53regulation of actin filament-based movement (GO:1903115)3.26683608
54response to inactivity (GO:0014854)3.26451511
55sperm-egg recognition (GO:0035036)3.15812628
56skeletal muscle adaptation (GO:0043501)3.14961910
57positive regulation of lipid storage (GO:0010884)3.13435005
58regulation of p38MAPK cascade (GO:1900744)3.13199579
59fibroblast migration (GO:0010761)3.08531875
60intracellular lipid transport (GO:0032365)3.06171296
61muscle tissue morphogenesis (GO:0060415)3.03619628
62striated muscle atrophy (GO:0014891)3.02969741
63negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.00589012
64hydrogen peroxide biosynthetic process (GO:0050665)2.99225378
65cellular response to epinephrine stimulus (GO:0071872)2.97858959
66reproduction (GO:0000003)2.97083034
67regulation of sarcomere organization (GO:0060297)2.96981778
68response to peptidoglycan (GO:0032494)2.96374335
69regulation of cholesterol storage (GO:0010885)2.94328729
70cellular extravasation (GO:0045123)2.90627182
71ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.89944988
72muscle atrophy (GO:0014889)2.89910463
73plasma membrane fusion (GO:0045026)2.89647387
74positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88969536
75regulation of striated muscle contraction (GO:0006942)2.88489248
76pericardium development (GO:0060039)2.86511025
77regulation of cell communication by electrical coupling (GO:0010649)2.85293677
78cell-cell recognition (GO:0009988)2.84741956
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83604961
80sequestering of metal ion (GO:0051238)2.82733092
81positive regulation by symbiont of host defense response (GO:0052509)2.81828769
82modulation by symbiont of host defense response (GO:0052031)2.81828769
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81828769
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81828769
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.81828769
86modulation by symbiont of host immune response (GO:0052553)2.81828769
87heart trabecula formation (GO:0060347)2.81719587
88cell communication involved in cardiac conduction (GO:0086065)2.80206964
89regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.79706013
90natural killer cell mediated immunity (GO:0002228)2.79165230
91natural killer cell mediated cytotoxicity (GO:0042267)2.79165230
92cilium or flagellum-dependent cell motility (GO:0001539)2.78233660
93macroautophagy (GO:0016236)2.78032387
94response to epinephrine (GO:0071871)2.77136614
95regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.74859270
96muscle contraction (GO:0006936)2.73377883
97binding of sperm to zona pellucida (GO:0007339)2.73320992
98regulation of cardioblast differentiation (GO:0051890)2.72008668
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71873457
100regulation of the force of heart contraction (GO:0002026)2.71132545
101phospholipid homeostasis (GO:0055091)2.71096401
102lysine metabolic process (GO:0006553)2.66371966
103lysine catabolic process (GO:0006554)2.66371966
104adhesion of symbiont to host cell (GO:0044650)2.65556693
105virion attachment to host cell (GO:0019062)2.65556693
106skeletal muscle contraction (GO:0003009)2.63719917
107cell migration involved in heart development (GO:0060973)2.62544989
108muscle adaptation (GO:0043500)2.62390701
109relaxation of cardiac muscle (GO:0055119)2.62049819
110positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.61596979
111striated muscle adaptation (GO:0014888)2.60011148
112hypotonic response (GO:0006971)2.59960683
113positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.58311028
114fatty acid beta-oxidation (GO:0006635)2.57759904
115endocardial cushion development (GO:0003197)2.57724391
116positive regulation of glycolytic process (GO:0045821)2.57506515
117muscle system process (GO:0003012)2.55956318
118positive regulation of p38MAPK cascade (GO:1900745)2.55934689
119negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.52943467
120interkinetic nuclear migration (GO:0022027)2.47160683
121cell-substrate junction assembly (GO:0007044)2.40113840
122growth hormone receptor signaling pathway (GO:0060396)2.37056342
123regulation of muscle system process (GO:0090257)2.34187733
124regulation of muscle contraction (GO:0006937)2.32649128
125response to muscle activity (GO:0014850)2.32227510
126regulation of integrin-mediated signaling pathway (GO:2001044)2.31377412
127regulation of vitamin D biosynthetic process (GO:0060556)2.30385221
128negative regulation of lipid storage (GO:0010888)2.28693413
129hemidesmosome assembly (GO:0031581)2.27794094
130cell adhesion mediated by integrin (GO:0033627)2.27447654
131regulation of necroptotic process (GO:0060544)2.26556397
132establishment of protein localization to Golgi (GO:0072600)2.23777668
133relaxation of muscle (GO:0090075)2.20138111
134response to redox state (GO:0051775)2.19807400
135regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19802358
136retrograde transport, vesicle recycling within Golgi (GO:0000301)2.18208056
137regulation of cardiac muscle hypertrophy (GO:0010611)2.17779699
138negative regulation of anoikis (GO:2000811)2.17444244
139skin morphogenesis (GO:0043589)2.16926326
140protein targeting to Golgi (GO:0000042)2.15805257
141cellular response to thyroid hormone stimulus (GO:0097067)2.14941949
142negative regulation of vascular permeability (GO:0043116)2.14514908
143regulation of cardiac muscle contraction (GO:0055117)2.13406955
144regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.13199357
145positive regulation of natural killer cell differentiation (GO:0032825)2.12533150
146adhesion of symbiont to host (GO:0044406)2.12437405
147regulation of calcium ion transmembrane transporter activity (GO:1901019)2.11532439
148regulation of calcium ion transmembrane transport (GO:1903169)2.11532439
149regulation of muscle hypertrophy (GO:0014743)2.10602060
150import into cell (GO:0098657)2.10346481
151interleukin-6-mediated signaling pathway (GO:0070102)2.10139067
152cellular response to growth hormone stimulus (GO:0071378)2.06636028
153regulation of vitamin metabolic process (GO:0030656)2.06605429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.88785218
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67836555
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34150931
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.22676169
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.71108606
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.68515678
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68272411
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.60624794
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.52298883
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.44398168
11* EP300_21415370_ChIP-Seq_HL-1_Mouse2.39622569
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38236377
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.37628117
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.24485387
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.24485387
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.14187679
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08808451
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.02898190
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00367530
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95122574
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94755584
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92406274
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91739133
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.90899148
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90781825
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85753042
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.85150715
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83575079
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83266359
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82790087
31TP53_16413492_ChIP-PET_HCT116_Human1.80253635
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.80140451
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.80140451
34* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79194232
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70812386
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70650640
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69879140
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67489143
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63904005
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63070356
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61904550
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59958015
43* BRD4_25478319_ChIP-Seq_HGPS_Human1.59663020
44MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56923089
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.51967642
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50241312
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45331014
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.41456443
49* GATA2_21666600_ChIP-Seq_HMVEC_Human1.40726662
50AHR_22903824_ChIP-Seq_MCF-7_Human1.37658838
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35722697
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35358783
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34136908
54* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33718551
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32114380
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30720770
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28836937
58GATA1_22025678_ChIP-Seq_K562_Human1.26382044
59ATF3_27146783_Chip-Seq_COLON_Human1.24301290
60GATA4_25053715_ChIP-Seq_YYC3_Human1.23983048
61ZNF263_19887448_ChIP-Seq_K562_Human1.23750114
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.22194357
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.21801817
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21743817
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20721046
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20250281
67GATA1_19941826_ChIP-Seq_K562_Human1.20239782
68SPI1_23127762_ChIP-Seq_K562_Human1.16462080
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16173951
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15738198
71VDR_24787735_ChIP-Seq_THP-1_Human1.15736455
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.14893006
73TP53_18474530_ChIP-ChIP_U2OS_Human1.14221550
74GATA6_25053715_ChIP-Seq_YYC3_Human1.13604525
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13329636
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.13259495
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12389690
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11933336
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10437724
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10437724
81* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09962431
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08460890
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07474825
84GBX2_23144817_ChIP-Seq_PC3_Human1.06386603
85CJUN_26792858_Chip-Seq_BT549_Human1.06222675
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05952535
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04120667
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03467274
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03158710
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02096191
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02008734
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01950504
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01669143
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01598860
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00555016
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00396408
97PU_27001747_Chip-Seq_BMDM_Mouse0.99955616
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99849174
99RUNX1_27514584_Chip-Seq_MCF-7_Human0.99189953
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99124496
101TCF7_22412390_ChIP-Seq_EML_Mouse0.98030090
102FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97318577
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96527479
104SMAD4_21799915_ChIP-Seq_A2780_Human0.96371497
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95481040
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95351273
107* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95171045
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.94903475
109SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92477363
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.92464503
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92460120
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92089737
113SPI1_20517297_ChIP-Seq_HL60_Human0.91790363
114RUNX_20019798_ChIP-Seq_JUKART_Human0.91592155
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91557272
116SOX2_20726797_ChIP-Seq_SW620_Human0.91245541
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91071830
118GATA2_19941826_ChIP-Seq_K562_Human0.90745588
119CLOCK_20551151_ChIP-Seq_293T_Human0.90684049
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90019886
121* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90012719
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.89953961
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88944552
124* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88492492
125* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88302725
126* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88241880
127* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88126405
128TP63_22573176_ChIP-Seq_HFKS_Human0.88045821
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87872442
130* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87387155
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86732586
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86677975
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86358399
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85053720
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.85028391
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84390794
137* TP63_23658742_ChIP-Seq_EP156T_Human0.84244133
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84006708
139* STAT3_23295773_ChIP-Seq_U87_Human0.83245139
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83137371
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82967471
142CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82784490
143EGR1_19032775_ChIP-ChIP_M12_Human0.82266151
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82196911
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81486189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.58992642
2MP0002837_dystrophic_cardiac_calcinosis4.34330814
3MP0004084_abnormal_cardiac_muscle3.80019404
4MP0000751_myopathy3.09205071
5MP0000749_muscle_degeneration3.01671855
6MP0004036_abnormal_muscle_relaxation2.93515189
7MP0008438_abnormal_cutaneous_collagen2.84537235
8MP0004510_myositis2.84040897
9MP0004215_abnormal_myocardial_fiber2.68989324
10MP0005330_cardiomyopathy2.48718560
11MP0004087_abnormal_muscle_fiber2.47593983
12MP0004130_abnormal_muscle_cell2.42856444
13MP0005410_abnormal_fertilization2.38855249
14MP0002972_abnormal_cardiac_muscle2.29955628
15MP0003279_aneurysm2.25449082
16MP0000750_abnormal_muscle_regeneration2.19711965
17MP0003828_pulmonary_edema2.17398116
18MP0003303_peritoneal_inflammation2.15112646
19MP0008775_abnormal_heart_ventricle2.14685888
20MP0009840_abnormal_foam_cell2.09761278
21MP0001958_emphysema2.05174677
22MP0010630_abnormal_cardiac_muscle2.01345144
23MP0005275_abnormal_skin_tensile1.94399516
24MP0003566_abnormal_cell_adhesion1.93890081
25MP0004484_altered_response_of1.92496501
26MP0005620_abnormal_muscle_contractility1.90481369
27MP0002106_abnormal_muscle_physiology1.88147256
28MP0005385_cardiovascular_system_phenoty1.86232192
29MP0001544_abnormal_cardiovascular_syste1.86232192
30MP0000569_abnormal_digit_pigmentation1.84776860
31MP0008004_abnormal_stomach_pH1.76981135
32MP0002269_muscular_atrophy1.76141609
33MP0003091_abnormal_cell_migration1.73596873
34MP0000343_altered_response_to1.73544755
35MP0004145_abnormal_muscle_electrophysio1.67582232
36MP0005670_abnormal_white_adipose1.67264096
37MP0003221_abnormal_cardiomyocyte_apopto1.66437143
38MP0005451_abnormal_body_composition1.65712882
39MP0005666_abnormal_adipose_tissue1.60597719
40MP0004185_abnormal_adipocyte_glucose1.55909817
41MP0003705_abnormal_hypodermis_morpholog1.54159548
42MP0005023_abnormal_wound_healing1.52700741
43MP0003436_decreased_susceptibility_to1.50798849
44MP0010234_abnormal_vibrissa_follicle1.43880200
45MP0004272_abnormal_basement_membrane1.43877073
46MP0006054_spinal_hemorrhage1.43404950
47MP0000747_muscle_weakness1.42997365
48MP0003950_abnormal_plasma_membrane1.42154081
49MP0002234_abnormal_pharynx_morphology1.41800705
50MP0000759_abnormal_skeletal_muscle1.36692346
51MP0002877_abnormal_melanocyte_morpholog1.35190881
52MP0005058_abnormal_lysosome_morphology1.32772727
53MP0005503_abnormal_tendon_morphology1.32704322
54MP0005369_muscle_phenotype1.30276205
55MP0003191_abnormal_cellular_cholesterol1.28628368
56MP0001542_abnormal_bone_strength1.28589271
57MP0006138_congestive_heart_failure1.24836514
58MP0000013_abnormal_adipose_tissue1.24324794
59MP0002139_abnormal_hepatobiliary_system1.24091446
60MP0003137_abnormal_impulse_conducting1.21289764
61MP0006036_abnormal_mitochondrial_physio1.18014734
62MP0002332_abnormal_exercise_endurance1.14698754
63MP0005164_abnormal_response_to1.13442942
64MP0003195_calcinosis1.12725290
65MP0004947_skin_inflammation1.12427550
66MP0009785_altered_susceptibility_to1.11531303
67MP0005319_abnormal_enzyme/_coenzyme1.06864971
68MP0005085_abnormal_gallbladder_physiolo1.05850872
69MP0005595_abnormal_vascular_smooth1.05444473
70MP0002998_abnormal_bone_remodeling1.03417795
71MP0002108_abnormal_muscle_morphology1.02750558
72MP0004085_abnormal_heartbeat0.99528219
73MP0005257_abnormal_intraocular_pressure0.99422696
74MP0002971_abnormal_brown_adipose0.97552364
75MP0003724_increased_susceptibility_to0.96106383
76MP0005375_adipose_tissue_phenotype0.94462185
77MP0002896_abnormal_bone_mineralization0.93463815
78MP0009384_cardiac_valve_regurgitation0.93297541
79MP0005076_abnormal_cell_differentiation0.92310340
80MP0003300_gastrointestinal_ulcer0.92233905
81MP0003453_abnormal_keratinocyte_physiol0.92155172
82MP0005365_abnormal_bile_salt0.91561864
83MP0002127_abnormal_cardiovascular_syste0.91313352
84MP0003252_abnormal_bile_duct0.90522288
85MP0005165_increased_susceptibility_to0.88181912
86MP0002419_abnormal_innate_immunity0.87494642
87MP0000230_abnormal_systemic_arterial0.86789226
88MP0010352_gastrointestinal_tract_polyps0.85651964
89MP0004233_abnormal_muscle_weight0.85605847
90MP0005360_urolithiasis0.85465771
91MP0000249_abnormal_blood_vessel0.85187503
92MP0000733_abnormal_muscle_development0.84057700
93MP0002796_impaired_skin_barrier0.83049292
94MP0003045_fibrosis0.82202592
95MP0005083_abnormal_biliary_tract0.80656638
96MP0003941_abnormal_skin_development0.80546128
97MP0002148_abnormal_hypersensitivity_rea0.79538309
98MP0000266_abnormal_heart_morphology0.78955653
99MP0005166_decreased_susceptibility_to0.77751904
100MP0002295_abnormal_pulmonary_circulatio0.77691994
101MP0001851_eye_inflammation0.77344158
102MP0001835_abnormal_antigen_presentation0.77000086
103MP0005464_abnormal_platelet_physiology0.76761446
104MP0001765_abnormal_ion_homeostasis0.76217139
105MP0001666_abnormal_nutrient_absorption0.75591417
106MP0002118_abnormal_lipid_homeostasis0.75580253
107MP0003183_abnormal_peptide_metabolism0.75278212
108MP0001879_abnormal_lymphatic_vessel0.74246754
109MP0005025_abnormal_response_to0.74240297
110MP0005167_abnormal_blood-brain_barrier0.74165383
111MP0002128_abnormal_blood_circulation0.73399958
112MP0002693_abnormal_pancreas_physiology0.72999168
113MP0008875_abnormal_xenobiotic_pharmacok0.72570537
114MP0009764_decreased_sensitivity_to0.71068789
115MP0002078_abnormal_glucose_homeostasis0.70805688
116MP0009278_abnormal_bone_marrow0.70799993
117MP0002909_abnormal_adrenal_gland0.69885922
118MP0000003_abnormal_adipose_tissue0.69734269
119MP0000609_abnormal_liver_physiology0.69682364
120MP0008469_abnormal_protein_level0.69663260
121MP0009115_abnormal_fat_cell0.67079388
122MP0010329_abnormal_lipoprotein_level0.66556171
123MP0005334_abnormal_fat_pad0.65934684
124MP0002638_abnormal_pupillary_reflex0.65538899
125MP0003656_abnormal_erythrocyte_physiolo0.65371718
126MP0010368_abnormal_lymphatic_system0.64927042
127MP0009643_abnormal_urine_homeostasis0.64917256
128MP0000767_abnormal_smooth_muscle0.64592958
129MP0006082_CNS_inflammation0.63155467
130MP0004883_abnormal_blood_vessel0.62942327
131MP0005390_skeleton_phenotype0.62810455
132MP0009780_abnormal_chondrocyte_physiolo0.62582957
133MP0002060_abnormal_skin_morphology0.62497222
134MP0005266_abnormal_metabolism0.62308211
135MP0001533_abnormal_skeleton_physiology0.62085539

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.32480783
2Ventricular tachycardia (HP:0004756)5.58512901
3Right ventricular cardiomyopathy (HP:0011663)5.20196318
4Exercise-induced muscle cramps (HP:0003710)5.18154104
5Hyporeflexia of lower limbs (HP:0002600)4.59697837
6Muscle fiber splitting (HP:0003555)4.50176492
7Exercise-induced myalgia (HP:0003738)4.43006908
8Calf muscle hypertrophy (HP:0008981)4.23461429
9Asymmetric septal hypertrophy (HP:0001670)4.07723971
10Myoglobinuria (HP:0002913)4.05043063
11Syncope (HP:0001279)4.04884745
12Bundle branch block (HP:0011710)3.96135630
13Atrial fibrillation (HP:0005110)3.94792741
14Lipoatrophy (HP:0100578)3.91255917
15Difficulty climbing stairs (HP:0003551)3.90562445
16Muscle hypertrophy of the lower extremities (HP:0008968)3.86020501
17Abnormality of the left ventricular outflow tract (HP:0011103)3.84078874
18Subaortic stenosis (HP:0001682)3.84078874
19Aortic aneurysm (HP:0004942)3.72992141
20Increased connective tissue (HP:0009025)3.64567968
21Abnormality of the calf musculature (HP:0001430)3.64346314
22Primary atrial arrhythmia (HP:0001692)3.62535994
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.43002213
24Supraventricular tachycardia (HP:0004755)3.42162826
25EMG: myopathic abnormalities (HP:0003458)3.39211526
26Supraventricular arrhythmia (HP:0005115)3.35043525
27Abnormality of skeletal muscle fiber size (HP:0012084)3.30209721
28Hypoglycemic coma (HP:0001325)3.27894279
29Rhabdomyolysis (HP:0003201)3.26665876
30Ventricular arrhythmia (HP:0004308)3.25998411
31Increased variability in muscle fiber diameter (HP:0003557)3.25500770
32Muscle fiber inclusion bodies (HP:0100299)3.22358852
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.21504976
34Protrusio acetabuli (HP:0003179)3.19793966
35Dilated cardiomyopathy (HP:0001644)3.19472202
36Abnormal atrioventricular conduction (HP:0005150)3.15439174
37Round ear (HP:0100830)3.09899028
38Heart block (HP:0012722)3.07911241
39Palpitations (HP:0001962)3.04399017
40Type 1 muscle fiber predominance (HP:0003803)3.02485715
41Insulin-resistant diabetes mellitus (HP:0000831)2.89392397
42Prolonged QT interval (HP:0001657)2.88880965
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.87939303
44Hyperglycemia (HP:0003074)2.82119142
45Scapular winging (HP:0003691)2.80267288
46Spinal rigidity (HP:0003306)2.79659277
47Distal lower limb muscle weakness (HP:0009053)2.79121757
48Difficulty running (HP:0009046)2.72151605
49Atrioventricular block (HP:0001678)2.67375615
50Hip contracture (HP:0003273)2.66665964
51Nemaline bodies (HP:0003798)2.65738105
52Hypoalphalipoproteinemia (HP:0003233)2.65539485
53Aortic dissection (HP:0002647)2.64125269
54Eczematoid dermatitis (HP:0000976)2.63751496
55Recurrent gram-negative bacterial infections (HP:0005420)2.62326624
56Nasal polyposis (HP:0100582)2.62213870
57Follicular hyperkeratosis (HP:0007502)2.51075411
58Ventricular fibrillation (HP:0001663)2.50668903
59Rimmed vacuoles (HP:0003805)2.43926719
60Abnormality of the nasal mucosa (HP:0000433)2.43082554
61Premature rupture of membranes (HP:0001788)2.39098644
62Areflexia of lower limbs (HP:0002522)2.38463503
63Recurrent abscess formation (HP:0002722)2.37921990
64Hyperinsulinemic hypoglycemia (HP:0000825)2.36265144
65Absent/shortened dynein arms (HP:0200106)2.33485587
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.33485587
67Ketoacidosis (HP:0001993)2.32116938
68Frequent falls (HP:0002359)2.29491898
69Vascular tortuosity (HP:0004948)2.29262596
70Mildly elevated creatine phosphokinase (HP:0008180)2.26519297
71Osteolytic defects of the hand bones (HP:0009699)2.26160285
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.26160285
73Atrophic scars (HP:0001075)2.25349881
74Spondylolisthesis (HP:0003302)2.24511995
75Myocardial infarction (HP:0001658)2.23677497
76Limited hip movement (HP:0008800)2.22761993
77Neck muscle weakness (HP:0000467)2.20029977
78EMG: neuropathic changes (HP:0003445)2.19915727
79Chronic bronchitis (HP:0004469)2.19788905
80Recurrent bacterial skin infections (HP:0005406)2.19621403
81Nausea (HP:0002018)2.14410350
82Mitral stenosis (HP:0001718)2.13882647
83Limb-girdle muscle atrophy (HP:0003797)2.10864648
84Palmoplantar keratoderma (HP:0000982)2.09483374
85Axonal loss (HP:0003447)2.09063286
86Abnormality of the foot musculature (HP:0001436)2.08556261
87Overgrowth (HP:0001548)2.07168168
88Foot dorsiflexor weakness (HP:0009027)2.06558363
89Gowers sign (HP:0003391)2.06039184
90Aneurysm (HP:0002617)2.04361295
91Polycythemia (HP:0001901)2.03302828
92Xanthomatosis (HP:0000991)2.01352123
93Neoplasm of head and neck (HP:0012288)2.00587442
94Esophageal neoplasm (HP:0100751)2.00587442
95Abnormality of the shoulder girdle musculature (HP:0001435)1.98823560
96Arterial tortuosity (HP:0005116)1.98656491
97Myotonia (HP:0002486)1.96463222
98Facial diplegia (HP:0001349)1.95678619
99Distal arthrogryposis (HP:0005684)1.95453612
100Ketosis (HP:0001946)1.95405387
101Myopathic facies (HP:0002058)1.94365138
102Achilles tendon contracture (HP:0001771)1.93320094
103Bulbar palsy (HP:0001283)1.92957375
104Wormian bones (HP:0002645)1.92576202
105Generalized muscle weakness (HP:0003324)1.92222069
106Muscular dystrophy (HP:0003560)1.90802740
107Slender build (HP:0001533)1.88988204
108Metaphyseal dysplasia (HP:0100255)1.88511291
109Limb-girdle muscle weakness (HP:0003325)1.88091372
110Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87751308
111Dicarboxylic aciduria (HP:0003215)1.87751308
112Neonatal short-limb short stature (HP:0008921)1.87171574
113Skin nodule (HP:0200036)1.86986948
114Tetraparesis (HP:0002273)1.85485788
115Abnormal EKG (HP:0003115)1.84654774
116Abnormality of the Achilles tendon (HP:0005109)1.83248050
117Abnormal respiratory motile cilium physiology (HP:0012261)1.82737754
118Distal lower limb amyotrophy (HP:0008944)1.82466169
119Hypoplasia of the iris (HP:0007676)1.81872203
120Late onset (HP:0003584)1.81661964
121Sudden cardiac death (HP:0001645)1.80024250
122Flat acetabular roof (HP:0003180)1.79325052
123Abnormality of fatty-acid metabolism (HP:0004359)1.79260319
124Knee flexion contracture (HP:0006380)1.76424612
125Generalized aminoaciduria (HP:0002909)1.75024512
126Muscle stiffness (HP:0003552)1.74025517
127Thick nail (HP:0001805)1.73980954
128Bradycardia (HP:0001662)1.72812421
129Increased muscle lipid content (HP:0009058)1.71864736
130Progressive muscle weakness (HP:0003323)1.71039206
131Steppage gait (HP:0003376)1.70520667
132Weak cry (HP:0001612)1.70191879
133Peritonitis (HP:0002586)1.70179179
134Cardiovascular calcification (HP:0011915)1.70031217
135Hyperkalemia (HP:0002153)1.69449549
136Ulnar deviation of the wrist (HP:0003049)1.69167679
137Lower limb amyotrophy (HP:0007210)1.69057437
138Aplasia of the musculature (HP:0100854)1.68122585
139Insulin resistance (HP:0000855)1.66846275
140Hypolipoproteinemia (HP:0010981)1.66136068
141Abnormality of the neuromuscular junction (HP:0003398)1.65293339
142Fatigable weakness (HP:0003473)1.65293339
143Conjunctival hamartoma (HP:0100780)1.65136815
144Easy fatigability (HP:0003388)1.64280907
145Abnormality of macrophages (HP:0004311)1.63375572
146Hypercholesterolemia (HP:0003124)1.63111648
147Left ventricular hypertrophy (HP:0001712)1.61950870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.95319685
2PDK33.94290521
3PDK43.94290521
4OBSCN3.87364975
5TTN3.66912985
6AKT33.17083675
7TRIB32.71087751
8MST1R2.43000868
9PDK22.31585143
10PKN22.30809364
11DDR22.30467319
12RIPK12.23468163
13DMPK1.91175393
14MAPKAPK31.82710311
15PIK3CA1.76605926
16CDC42BPA1.67005241
17RIPK41.59346136
18MAPK71.58718689
19INSRR1.57288743
20STK241.56918544
21LMTK21.52366229
22TBK11.51017633
23MYLK1.43635928
24MOS1.42631798
25KSR21.38192882
26MAP3K51.35811771
27MUSK1.34610954
28FLT31.33850752
29PHKG11.33095855
30PHKG21.33095855
31MAPK121.32838510
32PIK3CG1.32117926
33ERN11.31940656
34EPHA31.24655762
35TESK11.24441622
36MAP2K31.23248607
37MAP3K141.23094726
38ACVR1B1.16199178
39TGFBR21.13861414
40MAP3K11.09967779
41NEK91.07409551
42IRAK31.05292810
43TRPM71.04163050
44LATS21.00930585
45ILK1.00134546
46STK380.98847029
47MAP3K30.98055974
48WNK40.97016596
49ZAK0.96364791
50MAP3K20.94614807
51EPHB10.93084305
52PRKD30.92246780
53PTK20.91921880
54PIM20.91856653
55BCKDK0.90695292
56JAK10.89268083
57ROCK10.88796707
58PRKAA20.88701257
59HIPK20.88554432
60LATS10.86760453
61ERBB30.86614810
62PTK60.86093540
63TYK20.83864759
64PTK2B0.81709422
65MAP3K130.80898105
66MARK20.79621422
67PRKD20.78653346
68IRAK40.77195213
69KSR10.76949995
70PAK30.76705838
71EPHB20.74822364
72PAK20.74308368
73TAOK20.72769451
74BMPR20.72683183
75FRK0.71815826
76PINK10.70017597
77MAP3K70.69708872
78STK30.68137061
79MARK10.67304968
80PAK60.66458026
81SGK20.66245779
82ARAF0.64634471
83PDGFRA0.64256043
84PRPF4B0.63518849
85PRKD10.62520933
86JAK20.62408946
87STK40.62077425
88ABL20.59738960
89ADRBK10.59550966
90PRKAA10.59515696
91SGK30.59363767
92CAMK2D0.57275566
93DYRK1B0.56908392
94ERBB40.56511905
95MATK0.55610251
96MAP3K60.55562582
97RPS6KA20.55225224
98MAPK40.54996867
99TAOK10.54959106
100PDPK10.54754951
101IKBKB0.53201708
102MET0.52381784
103CHUK0.50188964
104NEK10.50064811
105PKN10.49860439
106PDK10.49324304
107PRKG20.49085057
108NTRK10.48937031
109RET0.48907428
110CSK0.48453377
111GRK70.48142243
112NUAK10.46997152
113ZAP700.45958288
114JAK30.44587003
115KIT0.44554983
116MAP2K20.44498147
117MAP2K40.44425285
118FER0.44023747
119ICK0.43578088
120MAPK130.43474982
121STK100.43043157
122LRRK20.42745751
123PRKG10.42236280
124TEC0.41619890
125WNK10.41084257
126NME20.40977983
127MAP2K10.40599964
128BRAF0.40485408
129IRAK10.39889255
130IKBKE0.39692631
131CAMK2G0.39574697
132BMX0.38063186
133DAPK30.37396444
134STK38L0.36925024
135PIM10.36887487
136PBK0.35982255
137RAF10.35035317
138PDGFRB0.34713979
139TIE10.34559702
140MAP3K110.33718067
141NEK20.33629349

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.53385639
2Fatty acid degradation_Homo sapiens_hsa000712.71495937
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47043515
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.46529382
5Cardiac muscle contraction_Homo sapiens_hsa042602.39813728
6Propanoate metabolism_Homo sapiens_hsa006402.32070133
7Dilated cardiomyopathy_Homo sapiens_hsa054142.23788278
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22400437
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.95735321
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88993056
11Carbon metabolism_Homo sapiens_hsa012001.82083686
12Circadian rhythm_Homo sapiens_hsa047101.77745011
13Sulfur metabolism_Homo sapiens_hsa009201.77443018
14PPAR signaling pathway_Homo sapiens_hsa033201.74786975
15ECM-receptor interaction_Homo sapiens_hsa045121.74447650
16Starch and sucrose metabolism_Homo sapiens_hsa005001.54465643
17Legionellosis_Homo sapiens_hsa051341.51843307
18Insulin resistance_Homo sapiens_hsa049311.49524500
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48919910
20Pyruvate metabolism_Homo sapiens_hsa006201.46563734
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.41824196
22Leishmaniasis_Homo sapiens_hsa051401.40317984
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40175105
24Fatty acid metabolism_Homo sapiens_hsa012121.39690987
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.30671111
26Selenocompound metabolism_Homo sapiens_hsa004501.29480083
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24687428
28Staphylococcus aureus infection_Homo sapiens_hsa051501.23822667
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.23760757
30Fat digestion and absorption_Homo sapiens_hsa049751.20270491
31Osteoclast differentiation_Homo sapiens_hsa043801.19406058
32Viral myocarditis_Homo sapiens_hsa054161.14623668
33Type II diabetes mellitus_Homo sapiens_hsa049301.14443621
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14036692
35Glucagon signaling pathway_Homo sapiens_hsa049221.12200588
36Galactose metabolism_Homo sapiens_hsa000521.12183232
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11742620
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09751538
39Arginine biosynthesis_Homo sapiens_hsa002201.09112467
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07385241
41Renin secretion_Homo sapiens_hsa049241.04770234
42Pentose phosphate pathway_Homo sapiens_hsa000301.03763984
43Oxytocin signaling pathway_Homo sapiens_hsa049211.03398124
44Mineral absorption_Homo sapiens_hsa049781.01784417
45Tryptophan metabolism_Homo sapiens_hsa003800.99015447
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98548031
47Amoebiasis_Homo sapiens_hsa051460.98203865
48Toxoplasmosis_Homo sapiens_hsa051450.97061422
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96514859
50Tuberculosis_Homo sapiens_hsa051520.96496960
51Calcium signaling pathway_Homo sapiens_hsa040200.94021377
52GnRH signaling pathway_Homo sapiens_hsa049120.92641610
53Salmonella infection_Homo sapiens_hsa051320.91954368
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91909560
55Dorso-ventral axis formation_Homo sapiens_hsa043200.86024980
56Oxidative phosphorylation_Homo sapiens_hsa001900.85598708
57TNF signaling pathway_Homo sapiens_hsa046680.85573598
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.84997801
59Malaria_Homo sapiens_hsa051440.83968553
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83757763
61Insulin signaling pathway_Homo sapiens_hsa049100.82707039
62ABC transporters_Homo sapiens_hsa020100.82667158
63African trypanosomiasis_Homo sapiens_hsa051430.81298018
64HIF-1 signaling pathway_Homo sapiens_hsa040660.80719854
65Parkinsons disease_Homo sapiens_hsa050120.80627158
66Alzheimers disease_Homo sapiens_hsa050100.79989802
67FoxO signaling pathway_Homo sapiens_hsa040680.79873282
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78409012
69Pertussis_Homo sapiens_hsa051330.77499472
70Influenza A_Homo sapiens_hsa051640.76130269
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.75702419
72Protein digestion and absorption_Homo sapiens_hsa049740.75611821
73Fructose and mannose metabolism_Homo sapiens_hsa000510.75302964
74MAPK signaling pathway_Homo sapiens_hsa040100.75082810
75Pancreatic secretion_Homo sapiens_hsa049720.74185318
76Fatty acid biosynthesis_Homo sapiens_hsa000610.74040645
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.74014964
78Huntingtons disease_Homo sapiens_hsa050160.73939192
79Complement and coagulation cascades_Homo sapiens_hsa046100.73295180
80Prion diseases_Homo sapiens_hsa050200.72503558
81Chronic myeloid leukemia_Homo sapiens_hsa052200.71224908
82VEGF signaling pathway_Homo sapiens_hsa043700.70658206
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69710285
84Bladder cancer_Homo sapiens_hsa052190.69685762
85Caffeine metabolism_Homo sapiens_hsa002320.68086089
86Pancreatic cancer_Homo sapiens_hsa052120.66928966
87Renal cell carcinoma_Homo sapiens_hsa052110.66220716
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66139255
89AMPK signaling pathway_Homo sapiens_hsa041520.65803096
90Small cell lung cancer_Homo sapiens_hsa052220.65566918
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.65559515
92Biosynthesis of amino acids_Homo sapiens_hsa012300.64869631
93Bile secretion_Homo sapiens_hsa049760.64868378
94Gap junction_Homo sapiens_hsa045400.64762868
95Lysine degradation_Homo sapiens_hsa003100.63332931
96Inositol phosphate metabolism_Homo sapiens_hsa005620.62058396
97Lysosome_Homo sapiens_hsa041420.61440976
98Peroxisome_Homo sapiens_hsa041460.60869926
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60625088
100Shigellosis_Homo sapiens_hsa051310.59962115
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59891572
102Other glycan degradation_Homo sapiens_hsa005110.59725521
103Phagosome_Homo sapiens_hsa041450.59498300
104cAMP signaling pathway_Homo sapiens_hsa040240.58845616
105ErbB signaling pathway_Homo sapiens_hsa040120.58085962
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57783287
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57129350
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56992322
109mTOR signaling pathway_Homo sapiens_hsa041500.55333940
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54922094
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54868561
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.54822690
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54756976
114Adherens junction_Homo sapiens_hsa045200.54369134
115Acute myeloid leukemia_Homo sapiens_hsa052210.54081400
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53970434
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53844408
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.53742948
119Estrogen signaling pathway_Homo sapiens_hsa049150.53370013
120Glycerolipid metabolism_Homo sapiens_hsa005610.53118818
121Chemokine signaling pathway_Homo sapiens_hsa040620.52879763
122Focal adhesion_Homo sapiens_hsa045100.52629923
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52612872
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52585362
125Glioma_Homo sapiens_hsa052140.52079153
126Endocytosis_Homo sapiens_hsa041440.51985496
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51247674
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51170855
129B cell receptor signaling pathway_Homo sapiens_hsa046620.50495117
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50380780
131Phenylalanine metabolism_Homo sapiens_hsa003600.50243709
132Rheumatoid arthritis_Homo sapiens_hsa053230.49730122
133Tight junction_Homo sapiens_hsa045300.49609087
134Apoptosis_Homo sapiens_hsa042100.48764234
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48617109
136Gastric acid secretion_Homo sapiens_hsa049710.47752457
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.45580186
138Linoleic acid metabolism_Homo sapiens_hsa005910.43536039
139Renin-angiotensin system_Homo sapiens_hsa046140.42671848
140Prolactin signaling pathway_Homo sapiens_hsa049170.42474055
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42327226
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.41586191
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40280776
144Proteoglycans in cancer_Homo sapiens_hsa052050.40121146
145Platelet activation_Homo sapiens_hsa046110.38665718
146Folate biosynthesis_Homo sapiens_hsa007900.37906965
147Hepatitis C_Homo sapiens_hsa051600.37612874
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37492961
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35927504

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