LRRFIP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.41295389
2centriole replication (GO:0007099)4.32780622
3piRNA metabolic process (GO:0034587)3.84162541
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72639565
5mast cell degranulation (GO:0043303)3.60402114
6mast cell activation involved in immune response (GO:0002279)3.60402114
7regulation of meiosis I (GO:0060631)3.58793266
8DNA methylation involved in gamete generation (GO:0043046)3.57764227
9positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.54855891
10rRNA modification (GO:0000154)3.54237089
11mannosylation (GO:0097502)3.46944599
12neutrophil mediated immunity (GO:0002446)3.44957045
13positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.38682311
14pseudouridine synthesis (GO:0001522)3.28013714
15response to interferon-beta (GO:0035456)3.19889997
16ubiquinone biosynthetic process (GO:0006744)3.18950351
17centriole assembly (GO:0098534)3.18104477
18cellular extravasation (GO:0045123)3.15225463
19tryptophan metabolic process (GO:0006568)3.11951287
20modulation of growth of symbiont involved in interaction with host (GO:0044144)3.10981154
21regulation of growth of symbiont in host (GO:0044126)3.10981154
22negative regulation of growth of symbiont in host (GO:0044130)3.10981154
23negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.10981154
24RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06660910
25water-soluble vitamin biosynthetic process (GO:0042364)3.05416995
26rRNA methylation (GO:0031167)3.02262961
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96494690
28tryptophan catabolic process (GO:0006569)2.96334533
29indole-containing compound catabolic process (GO:0042436)2.96334533
30indolalkylamine catabolic process (GO:0046218)2.96334533
31positive regulation of histone H3-K4 methylation (GO:0051571)2.94553120
32rRNA catabolic process (GO:0016075)2.93998975
33synapsis (GO:0007129)2.93404657
34respiratory chain complex IV assembly (GO:0008535)2.90842455
35ribosome biogenesis (GO:0042254)2.89139273
36kynurenine metabolic process (GO:0070189)2.86730670
37regulation of mitotic spindle checkpoint (GO:1903504)2.86686148
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86686148
39iron-sulfur cluster assembly (GO:0016226)2.82331567
40metallo-sulfur cluster assembly (GO:0031163)2.82331567
41killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.82106484
42disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.82106484
43protein complex biogenesis (GO:0070271)2.74628132
44immunoglobulin mediated immune response (GO:0016064)2.73721830
45mast cell activation (GO:0045576)2.72873050
46regulation of centriole replication (GO:0046599)2.72084121
47ubiquinone metabolic process (GO:0006743)2.71773538
48mitochondrial respiratory chain complex assembly (GO:0033108)2.70726858
49histone H2A acetylation (GO:0043968)2.69752128
50positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.69270728
51male meiosis (GO:0007140)2.68381104
52positive regulation of B cell differentiation (GO:0045579)2.67731495
53phosphorylated carbohydrate dephosphorylation (GO:0046838)2.66522384
54inositol phosphate dephosphorylation (GO:0046855)2.66522384
55mitotic sister chromatid cohesion (GO:0007064)2.66109940
56double-strand break repair via homologous recombination (GO:0000724)2.65629378
57establishment of protein localization to Golgi (GO:0072600)2.63969512
58quinone biosynthetic process (GO:1901663)2.63523394
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.62664674
60NADH dehydrogenase complex assembly (GO:0010257)2.62664674
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62664674
62recombinational repair (GO:0000725)2.61530483
63postreplication repair (GO:0006301)2.61095623
64regulation of chemokine biosynthetic process (GO:0045073)2.54744921
65DNA synthesis involved in DNA repair (GO:0000731)2.54716029
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.53922813
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53730712
68cellular response to interferon-beta (GO:0035458)2.52968951
69positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52382211
70regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52382211
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49907290
72translesion synthesis (GO:0019985)2.49526694
73regulation of histone H3-K4 methylation (GO:0051569)2.48259185
74ncRNA catabolic process (GO:0034661)2.48190001
75positive regulation of T cell cytokine production (GO:0002726)2.47971817
76regulation of mitochondrial translation (GO:0070129)2.47312725
77cellular ketone body metabolic process (GO:0046950)2.46348004
78fucose catabolic process (GO:0019317)2.45133795
79L-fucose metabolic process (GO:0042354)2.45133795
80L-fucose catabolic process (GO:0042355)2.45133795
81tRNA aminoacylation for protein translation (GO:0006418)2.44868351
82kinetochore organization (GO:0051383)2.44519544
83positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.44313212
84regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.44313212
85platelet dense granule organization (GO:0060155)2.43959816
86tRNA modification (GO:0006400)2.41522294
87cytochrome complex assembly (GO:0017004)2.40675716
88tRNA processing (GO:0008033)2.40397072
89protein targeting to Golgi (GO:0000042)2.39603001
90regulation of cilium movement (GO:0003352)2.39519554
91sleep (GO:0030431)2.39449301
92DNA modification (GO:0006304)2.39011973
93amino acid activation (GO:0043038)2.38238432
94tRNA aminoacylation (GO:0043039)2.38238432
95regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.37994380
96positive regulation of megakaryocyte differentiation (GO:0045654)2.37536481
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.37101318
98myeloid leukocyte mediated immunity (GO:0002444)2.36660221
99mitochondrial RNA metabolic process (GO:0000959)2.35459655
100transcription from RNA polymerase III promoter (GO:0006383)2.34986089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05437268
2E2F7_22180533_ChIP-Seq_HELA_Human3.92265802
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.48951803
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.28741574
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86017546
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.77713048
7VDR_23849224_ChIP-Seq_CD4+_Human2.73101683
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64701279
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57062423
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.54689137
11ELK1_19687146_ChIP-ChIP_HELA_Human2.54495391
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53622657
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53601745
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47908527
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42578126
16VDR_22108803_ChIP-Seq_LS180_Human2.41555987
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.38433984
18CIITA_25753668_ChIP-Seq_RAJI_Human2.37134239
19FOXP3_21729870_ChIP-Seq_TREG_Human2.23131531
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08125362
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.00490772
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98253817
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89196618
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.86843171
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81835898
26ZNF274_21170338_ChIP-Seq_K562_Hela1.80886521
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79515601
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74804325
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70695482
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69662460
31GABP_19822575_ChIP-Seq_HepG2_Human1.68443610
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.65904513
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60183429
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59374121
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59302920
36DCP1A_22483619_ChIP-Seq_HELA_Human1.57233279
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56892139
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56101688
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.50161264
40KDM5A_27292631_Chip-Seq_BREAST_Human1.46493134
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46385008
42MYB_26560356_Chip-Seq_TH2_Human1.44013225
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39220467
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39102333
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39012043
46IRF1_19129219_ChIP-ChIP_H3396_Human1.38985831
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38925887
48EWS_26573619_Chip-Seq_HEK293_Human1.35498637
49SCL_19346495_ChIP-Seq_HPC-7_Human1.35002682
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34926643
51SPI1_23547873_ChIP-Seq_NB4_Human1.34751778
52MYC_18940864_ChIP-ChIP_HL60_Human1.32103017
53TTF2_22483619_ChIP-Seq_HELA_Human1.27444546
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.26936357
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26575348
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25704075
57TP53_22573176_ChIP-Seq_HFKS_Human1.24737099
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20719799
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19687220
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18768335
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16534263
62GATA3_26560356_Chip-Seq_TH2_Human1.16530324
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.16267377
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15808605
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.14617932
66MYB_26560356_Chip-Seq_TH1_Human1.12622374
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10137819
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09305187
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07367647
70CBP_20019798_ChIP-Seq_JUKART_Human1.07367647
71FUS_26573619_Chip-Seq_HEK293_Human1.07125245
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06903638
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04944526
74XRN2_22483619_ChIP-Seq_HELA_Human1.03947261
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03915587
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01527060
77ER_23166858_ChIP-Seq_MCF-7_Human0.98953976
78RBPJ_21746931_ChIP-Seq_IB4_Human0.97369322
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96662431
80MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94071248
81GATA3_26560356_Chip-Seq_TH1_Human0.93956082
82TAF2_19829295_ChIP-Seq_ESCs_Human0.92865390
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.91256293
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91156880
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91145272
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91106068
87ETV1_20927104_ChIP-Seq_GIST48_Human0.90207285
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89929815
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89242088
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88906884
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.88754460
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88381780
93TFEB_21752829_ChIP-Seq_HELA_Human0.87434329
94GATA3_27048872_Chip-Seq_THYMUS_Human0.87007724
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.86491043
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86166859
97HOXB7_26014856_ChIP-Seq_BT474_Human0.85096678
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85091520
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84978255
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83341038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.39175081
2MP0008877_abnormal_DNA_methylation3.30446605
3MP0008995_early_reproductive_senescence3.21425955
4MP0008058_abnormal_DNA_repair2.92025707
5MP0009697_abnormal_copulation2.75663141
6MP0005397_hematopoietic_system_phenotyp2.51683128
7MP0001545_abnormal_hematopoietic_system2.51683128
8MP0006292_abnormal_olfactory_placode2.37323405
9MP0003693_abnormal_embryo_hatching2.30366171
10MP0002166_altered_tumor_susceptibility2.27102773
11MP0001835_abnormal_antigen_presentation2.10786275
12MP0002396_abnormal_hematopoietic_system2.08206868
13MP0003195_calcinosis2.05262264
14MP0005671_abnormal_response_to2.00122185
15MP0005075_abnormal_melanosome_morpholog1.95509373
16MP0004147_increased_porphyrin_level1.95062676
17MP0002006_tumorigenesis1.92775412
18MP0004043_abnormal_pH_regulation1.89571086
19MP0010094_abnormal_chromosome_stability1.89007978
20MP0003111_abnormal_nucleus_morphology1.84095283
21MP0003656_abnormal_erythrocyte_physiolo1.80775989
22MP0006036_abnormal_mitochondrial_physio1.80548560
23MP0003786_premature_aging1.80509605
24MP0005410_abnormal_fertilization1.72442845
25MP0002736_abnormal_nociception_after1.68023242
26MP0003806_abnormal_nucleotide_metabolis1.64538420
27MP0006035_abnormal_mitochondrial_morpho1.62546648
28MP0005646_abnormal_pituitary_gland1.57959861
29MP0004957_abnormal_blastocyst_morpholog1.52336745
30MP0010307_abnormal_tumor_latency1.48320445
31MP0003718_maternal_effect1.47668696
32MP0001968_abnormal_touch/_nociception1.46844640
33MP0001800_abnormal_humoral_immune1.43595962
34MP0003252_abnormal_bile_duct1.40376618
35MP0001929_abnormal_gametogenesis1.38656969
36MP0008872_abnormal_physiological_respon1.38528889
37MP0001873_stomach_inflammation1.37497970
38MP0002398_abnormal_bone_marrow1.34768694
39MP0002722_abnormal_immune_system1.30246176
40MP0000465_gastrointestinal_hemorrhage1.30015058
41MP0009785_altered_susceptibility_to1.28844791
42MP0000689_abnormal_spleen_morphology1.28085001
43MP0002132_abnormal_respiratory_system1.26910865
44MP0002095_abnormal_skin_pigmentation1.26234091
45MP0003950_abnormal_plasma_membrane1.25302107
46MP0003172_abnormal_lysosome_physiology1.24296059
47MP0002723_abnormal_immune_serum1.23622687
48MP0002420_abnormal_adaptive_immunity1.20066508
49MP0001853_heart_inflammation1.18646540
50MP0001819_abnormal_immune_cell1.18613976
51MP0002928_abnormal_bile_duct1.18584336
52MP0005000_abnormal_immune_tolerance1.18451323
53MP0005025_abnormal_response_to1.16517218
54MP0005174_abnormal_tail_pigmentation1.16461729
55MP0003436_decreased_susceptibility_to1.15355860
56MP0002452_abnormal_antigen_presenting1.14681972
57MP0002019_abnormal_tumor_incidence1.14423277
58MP0002009_preneoplasia1.14008676
59MP0000716_abnormal_immune_system1.12497974
60MP0006072_abnormal_retinal_apoptosis1.11736088
61MP0003077_abnormal_cell_cycle1.11689745
62MP0000703_abnormal_thymus_morphology1.09990417
63MP0002419_abnormal_innate_immunity1.09393559
64MP0008873_increased_physiological_sensi1.07930994
65MP0003763_abnormal_thymus_physiology1.06966626
66MP0002139_abnormal_hepatobiliary_system1.05474082
67MP0005551_abnormal_eye_electrophysiolog1.04558893
68MP0002148_abnormal_hypersensitivity_rea1.02923569
69MP0002429_abnormal_blood_cell1.01169042
70MP0000372_irregular_coat_pigmentation1.00481382
71MP0005636_abnormal_mineral_homeostasis0.99128596
72MP0008932_abnormal_embryonic_tissue0.97614421
73MP0003698_abnormal_male_reproductive0.96791854
74MP0005379_endocrine/exocrine_gland_phen0.96368170
75MP0002210_abnormal_sex_determination0.95594059
76MP0009764_decreased_sensitivity_to0.93638945
77MP0000685_abnormal_immune_system0.92922834
78MP0005464_abnormal_platelet_physiology0.92686481
79MP0000653_abnormal_sex_gland0.90030151
80MP0005389_reproductive_system_phenotype0.88224035
81MP0001764_abnormal_homeostasis0.88025862
82MP0004782_abnormal_surfactant_physiolog0.87815450
83MP0001119_abnormal_female_reproductive0.87178886
84MP0001145_abnormal_male_reproductive0.86800142
85MP0009333_abnormal_splenocyte_physiolog0.86633826
86MP0001986_abnormal_taste_sensitivity0.86608415
87MP0000358_abnormal_cell_content/0.86168659
88MP0008007_abnormal_cellular_replicative0.85166607
89MP0000427_abnormal_hair_cycle0.84421213
90MP0002163_abnormal_gland_morphology0.83647935
91MP0008469_abnormal_protein_level0.83408264
92MP0005220_abnormal_exocrine_pancreas0.81655749
93MP0002876_abnormal_thyroid_physiology0.81484504
94MP0003787_abnormal_imprinting0.81346690
95MP0001790_abnormal_immune_system0.81266781
96MP0005387_immune_system_phenotype0.81266781
97MP0001919_abnormal_reproductive_system0.79434326
98MP0001661_extended_life_span0.77283673
99MP0005266_abnormal_metabolism0.75344316
100MP0010329_abnormal_lipoprotein_level0.73757766

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.20623837
2Type I transferrin isoform profile (HP:0003642)3.82078182
3Volvulus (HP:0002580)3.68851090
4Pancreatic cysts (HP:0001737)3.28680891
5Hepatocellular necrosis (HP:0001404)3.21404099
6Chromsome breakage (HP:0040012)3.18505964
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.99959619
8Abnormal protein N-linked glycosylation (HP:0012347)2.99959619
9Abnormal protein glycosylation (HP:0012346)2.99959619
10Abnormal glycosylation (HP:0012345)2.99959619
11Increased CSF lactate (HP:0002490)2.97191872
12B lymphocytopenia (HP:0010976)2.89885279
13Abnormality of the prostate (HP:0008775)2.89521223
14Abnormality of DNA repair (HP:0003254)2.89124722
15Hepatic necrosis (HP:0002605)2.88368578
16Renal cortical cysts (HP:0000803)2.86950858
17Mitochondrial inheritance (HP:0001427)2.85327505
18Abnormality of B cell number (HP:0010975)2.85052927
19Acute necrotizing encephalopathy (HP:0006965)2.80862254
20Granulocytopenia (HP:0001913)2.80368028
21Eosinophilia (HP:0001880)2.78062229
22Pancreatic fibrosis (HP:0100732)2.77107572
23Progressive macrocephaly (HP:0004481)2.76921294
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.63507413
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63389716
26Abnormal number of erythroid precursors (HP:0012131)2.61123306
27Abnormality of the renal cortex (HP:0011035)2.60725322
28Abnormal mitochondria in muscle tissue (HP:0008316)2.59009579
29Severe combined immunodeficiency (HP:0004430)2.55051920
30Molar tooth sign on MRI (HP:0002419)2.52473421
31Abnormality of midbrain morphology (HP:0002418)2.52473421
32Large for gestational age (HP:0001520)2.50170259
33True hermaphroditism (HP:0010459)2.44138704
34Abnormality of eosinophils (HP:0001879)2.42518501
35Abnormality of male internal genitalia (HP:0000022)2.40616258
36Acute encephalopathy (HP:0006846)2.39954512
37Increased serum lactate (HP:0002151)2.39903854
38Protruding tongue (HP:0010808)2.39499581
39Pancreatic islet-cell hyperplasia (HP:0004510)2.30763891
40Chronic hepatic failure (HP:0100626)2.30612932
41Acute myeloid leukemia (HP:0004808)2.28132043
42Nephronophthisis (HP:0000090)2.27930795
43Poikiloderma (HP:0001029)2.23935617
44Elevated erythrocyte sedimentation rate (HP:0003565)2.23353988
45Abnormality of the ileum (HP:0001549)2.19968093
46Pancytopenia (HP:0001876)2.19967051
47Abnormality of chromosome stability (HP:0003220)2.16879900
48Acute lymphatic leukemia (HP:0006721)2.16152372
49Abnormality of cells of the erythroid lineage (HP:0012130)2.14551051
50IgG deficiency (HP:0004315)2.14342009
51Abnormality of the renal medulla (HP:0100957)2.09010273
52Entropion (HP:0000621)2.08490834
53Stomach cancer (HP:0012126)2.08032592
54Poikilocytosis (HP:0004447)2.07301403
55Increased serum pyruvate (HP:0003542)2.04535847
56Nephroblastoma (Wilms tumor) (HP:0002667)2.02816118
57Aplasia/Hypoplasia of the thymus (HP:0010515)2.01519609
58Cerebral edema (HP:0002181)2.01368493
59Alveolar cell carcinoma (HP:0006519)2.01014518
60Neutropenia (HP:0001875)2.00762101
61Duplicated collecting system (HP:0000081)2.00152539
62Abnormality of T cell physiology (HP:0011840)1.98370051
63Aplastic anemia (HP:0001915)1.96452982
64Combined immunodeficiency (HP:0005387)1.95239241
65Neoplasm of the adrenal cortex (HP:0100641)1.94743876
66Progressive microcephaly (HP:0000253)1.92978318
67Embryonal renal neoplasm (HP:0011794)1.92730992
68Reduced antithrombin III activity (HP:0001976)1.91353208
69Thyroiditis (HP:0100646)1.90730964
70Hypoproteinemia (HP:0003075)1.89960956
71Myelodysplasia (HP:0002863)1.88548034
72Tinnitus (HP:0000360)1.88380290
73Reticulocytosis (HP:0001923)1.88312220
74Leukocytosis (HP:0001974)1.88011815
75Congenital, generalized hypertrichosis (HP:0004540)1.85077214
76Lactic acidosis (HP:0003128)1.84373242
77Abnormality of the pons (HP:0007361)1.84157077
78Pulmonary fibrosis (HP:0002206)1.83447394
79Short middle phalanx of the 5th finger (HP:0004220)1.81220142
80Brushfield spots (HP:0001088)1.80837627
81Microvesicular hepatic steatosis (HP:0001414)1.80457058
82Spontaneous abortion (HP:0005268)1.77174157
83Abnormality of T cells (HP:0002843)1.76897919
84Fair hair (HP:0002286)1.75198072
85Abnormality of the preputium (HP:0100587)1.74280478
86Hypoplasia of the pons (HP:0012110)1.73897446
87Sloping forehead (HP:0000340)1.73157174
88Duodenal stenosis (HP:0100867)1.73146241
89Small intestinal stenosis (HP:0012848)1.73146241
90Capillary hemangiomas (HP:0005306)1.72642297
91Abnormality of the renal collecting system (HP:0004742)1.71595290
92Squamous cell carcinoma (HP:0002860)1.71566330
93Meckel diverticulum (HP:0002245)1.69403296
94Neoplasm of the tracheobronchial system (HP:0100552)1.67885728
95Hypertensive crisis (HP:0100735)1.66054554
96Abnormality of reticulocytes (HP:0004312)1.65995008
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.64898814
98Acanthocytosis (HP:0001927)1.62998579
99Hypoplasia of the thymus (HP:0000778)1.62456501
100Optic disc pallor (HP:0000543)1.62445861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.14604930
2NUAK13.30821689
3TAOK33.26497045
4BMPR23.23996202
5TNIK3.01364346
6ZAK2.94725222
7MST42.90213693
8SCYL22.82067680
9TXK2.57974733
10MAP4K22.46992270
11PLK42.23565065
12RIPK42.11355405
13PIK3CG2.05596301
14TEC2.04213748
15EIF2AK31.75645103
16WNK41.69696114
17KDR1.68376462
18VRK21.65233567
19TLK11.63786637
20IKBKB1.54217711
21KIT1.51418535
22CDK81.45221201
23TTK1.40813791
24SIK21.40132102
25BRSK21.36051219
26JAK31.31653151
27MAP4K11.30352610
28FES1.28789683
29ATR1.24633992
30BUB11.23044112
31INSRR1.21565545
32MKNK21.21304167
33OXSR11.20546422
34CDC71.18211387
35PDK21.12034679
36IKBKE1.10541899
37SRPK11.06738155
38MAP3K121.06158295
39ADRBK21.05679774
40CDK31.03074923
41MAP3K140.96305674
42TBK10.95685997
43CHEK20.95015562
44SYK0.94079799
45LYN0.89642324
46STK30.83372020
47BMPR1B0.81122231
48MKNK10.79149645
49VRK10.78878828
50NEK20.75841438
51TESK20.75235093
52STK40.72908434
53GRK10.72487666
54CDK190.72148573
55ATM0.70758504
56EIF2AK10.70292969
57STK160.69823225
58ITK0.68782786
59NLK0.65821462
60MARK30.64616238
61MAP3K20.63643594
62RPS6KB20.62780760
63FLT30.62426333
64RPS6KA50.62239850
65CHEK10.61629056
66CDK40.59362179
67BTK0.58796026
68BCKDK0.57787471
69PLK20.55430991
70LCK0.55178645
71PLK10.54477506
72CSF1R0.53392394
73EIF2AK20.51778363
74CHUK0.50058474
75MUSK0.48361908
76TRPM70.47017700
77CCNB10.45226868
78PRKCI0.45211529
79BRD40.44031304
80TNK20.42950092
81DMPK0.42559219
82MAP3K70.42490147
83PRKAA20.42473648
84STK100.42331001
85ABL10.42207354
86GRK60.42011894
87STK390.41793050
88NME10.41658973
89AURKB0.40937374
90RPS6KA40.40692425
91CLK10.38980827
92PBK0.38111371
93NME20.37883854
94STK38L0.36972716
95PRKCQ0.36918058
96IRAK10.36862624
97CDK70.36807123
98MATK0.36677658
99PIM10.35406701
100CSNK2A20.34034444

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.90058381
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.12173840
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91181586
4Allograft rejection_Homo sapiens_hsa053302.80766301
5Autoimmune thyroid disease_Homo sapiens_hsa053202.76291945
6Graft-versus-host disease_Homo sapiens_hsa053322.75727532
7Homologous recombination_Homo sapiens_hsa034402.73449281
8Proteasome_Homo sapiens_hsa030502.63940620
9One carbon pool by folate_Homo sapiens_hsa006702.42671329
10Type I diabetes mellitus_Homo sapiens_hsa049402.39399218
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36059812
12RNA polymerase_Homo sapiens_hsa030202.20246093
13Non-homologous end-joining_Homo sapiens_hsa034502.07691303
14Oxidative phosphorylation_Homo sapiens_hsa001901.98915462
15DNA replication_Homo sapiens_hsa030301.98846471
16Fanconi anemia pathway_Homo sapiens_hsa034601.97701037
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91321772
18Primary immunodeficiency_Homo sapiens_hsa053401.87174606
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85319889
20Antigen processing and presentation_Homo sapiens_hsa046121.75081560
21Base excision repair_Homo sapiens_hsa034101.72307917
22Protein export_Homo sapiens_hsa030601.68317119
23Parkinsons disease_Homo sapiens_hsa050121.65230758
24Mismatch repair_Homo sapiens_hsa034301.57891385
25RNA transport_Homo sapiens_hsa030131.56675792
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54598475
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53791912
28Leishmaniasis_Homo sapiens_hsa051401.53744500
29Nucleotide excision repair_Homo sapiens_hsa034201.48067982
30Butanoate metabolism_Homo sapiens_hsa006501.46005491
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44918824
32Staphylococcus aureus infection_Homo sapiens_hsa051501.43810992
33Spliceosome_Homo sapiens_hsa030401.42999890
34RNA degradation_Homo sapiens_hsa030181.41227677
35Selenocompound metabolism_Homo sapiens_hsa004501.41052732
36Basal transcription factors_Homo sapiens_hsa030221.40289963
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27999265
38Rheumatoid arthritis_Homo sapiens_hsa053231.24280239
39Ribosome_Homo sapiens_hsa030101.23744444
40Huntingtons disease_Homo sapiens_hsa050161.15156546
41Herpes simplex infection_Homo sapiens_hsa051681.13741730
42Pyrimidine metabolism_Homo sapiens_hsa002401.12553947
43Viral myocarditis_Homo sapiens_hsa054161.11972967
44Phototransduction_Homo sapiens_hsa047441.09323049
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00201350
46Systemic lupus erythematosus_Homo sapiens_hsa053220.95389311
47Alzheimers disease_Homo sapiens_hsa050100.89448761
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89183052
49Epstein-Barr virus infection_Homo sapiens_hsa051690.85524715
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81223111
51Peroxisome_Homo sapiens_hsa041460.78678601
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78448251
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78043613
54Purine metabolism_Homo sapiens_hsa002300.77850694
55Tryptophan metabolism_Homo sapiens_hsa003800.77011964
56Regulation of autophagy_Homo sapiens_hsa041400.76736466
57mRNA surveillance pathway_Homo sapiens_hsa030150.74260313
58Lysine degradation_Homo sapiens_hsa003100.73173689
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.71981534
60Influenza A_Homo sapiens_hsa051640.67925169
61Fatty acid metabolism_Homo sapiens_hsa012120.67533790
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.66145106
63Olfactory transduction_Homo sapiens_hsa047400.65280873
64Hematopoietic cell lineage_Homo sapiens_hsa046400.64059290
65Propanoate metabolism_Homo sapiens_hsa006400.63841123
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57402550
67Toxoplasmosis_Homo sapiens_hsa051450.56221474
68Measles_Homo sapiens_hsa051620.55898899
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.54986495
70Cell cycle_Homo sapiens_hsa041100.52076783
71Glutathione metabolism_Homo sapiens_hsa004800.50120658
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48953302
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.46726332
74Pyruvate metabolism_Homo sapiens_hsa006200.46300108
75Fatty acid elongation_Homo sapiens_hsa000620.46190119
76Nitrogen metabolism_Homo sapiens_hsa009100.44388020
77Tuberculosis_Homo sapiens_hsa051520.44223106
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44220373
79Metabolic pathways_Homo sapiens_hsa011000.41814569
80Linoleic acid metabolism_Homo sapiens_hsa005910.41375735
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39452357
82B cell receptor signaling pathway_Homo sapiens_hsa046620.38749268
83Legionellosis_Homo sapiens_hsa051340.37519032
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.34430480
85p53 signaling pathway_Homo sapiens_hsa041150.32866288
86Folate biosynthesis_Homo sapiens_hsa007900.32550840
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32344199
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32054063
89N-Glycan biosynthesis_Homo sapiens_hsa005100.29936592
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26757994
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26181615
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25663624
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25525468
94Vitamin B6 metabolism_Homo sapiens_hsa007500.24140343
95Fatty acid degradation_Homo sapiens_hsa000710.23843594
96African trypanosomiasis_Homo sapiens_hsa051430.23220739
97ABC transporters_Homo sapiens_hsa020100.22048023
98Chemical carcinogenesis_Homo sapiens_hsa052040.21626776
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21569041
100HTLV-I infection_Homo sapiens_hsa051660.21368121

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