LRRC8E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.15387470
2regulation of female gonad development (GO:2000194)4.75009927
3regulation of hippo signaling (GO:0035330)4.29051771
4negative regulation of keratinocyte proliferation (GO:0010839)4.03994592
5piRNA metabolic process (GO:0034587)3.97756987
6behavioral response to nicotine (GO:0035095)3.78127342
7cornea development in camera-type eye (GO:0061303)3.76607431
8GDP-mannose metabolic process (GO:0019673)3.72708198
9hemidesmosome assembly (GO:0031581)3.64955277
10superoxide anion generation (GO:0042554)3.64461881
11protein K6-linked ubiquitination (GO:0085020)3.63791038
12water-soluble vitamin biosynthetic process (GO:0042364)3.35961609
13mannosylation (GO:0097502)3.35184808
14sphingoid metabolic process (GO:0046519)3.31255543
15lipoxygenase pathway (GO:0019372)3.31047909
16regulation of RIG-I signaling pathway (GO:0039535)3.29159445
17sphingosine metabolic process (GO:0006670)3.28026760
18female gonad development (GO:0008585)3.27904109
19regulation of interleukin-8 secretion (GO:2000482)3.25745948
20regulation of activation of Janus kinase activity (GO:0010533)3.24883530
21pseudouridine synthesis (GO:0001522)3.20067769
22preassembly of GPI anchor in ER membrane (GO:0016254)3.19012531
23positive regulation of interleukin-1 beta secretion (GO:0050718)3.16582017
24meiotic chromosome segregation (GO:0045132)3.16522295
25regulation of hypersensitivity (GO:0002883)3.16010816
26negative regulation of mast cell activation (GO:0033004)3.14343803
27cellular response to ATP (GO:0071318)3.14314793
28peptidyl-histidine modification (GO:0018202)3.10116014
29bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04315777
30regulation of keratinocyte proliferation (GO:0010837)3.03385115
31detection of other organism (GO:0098543)3.02999504
32diol metabolic process (GO:0034311)3.02195049
33microtubule depolymerization (GO:0007019)3.01075565
34mitotic metaphase plate congression (GO:0007080)2.98693634
35negative regulation of homotypic cell-cell adhesion (GO:0034111)2.96587038
36nucleoside transmembrane transport (GO:1901642)2.96431893
37regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.96092201
38detection of bacterium (GO:0016045)2.90956143
39tRNA methylation (GO:0030488)2.89280715
40positive regulation of interleukin-1 secretion (GO:0050716)2.88647093
41centriole assembly (GO:0098534)2.88639853
42cardiac right ventricle morphogenesis (GO:0003215)2.87893951
43multicellular organism reproduction (GO:0032504)2.87035429
44establishment of skin barrier (GO:0061436)2.84231778
45tRNA modification (GO:0006400)2.77340404
46positive regulation of interleukin-1 beta production (GO:0032731)2.73487501
47sulfate transport (GO:0008272)2.73278443
48regulation of interleukin-1 beta secretion (GO:0050706)2.73075244
49telomere maintenance via telomerase (GO:0007004)2.72705476
50oocyte maturation (GO:0001556)2.72461282
51positive regulation of cellular amide metabolic process (GO:0034250)2.71934748
52pattern specification involved in kidney development (GO:0061004)2.71589803
53DNA methylation involved in gamete generation (GO:0043046)2.71489920
54positive regulation of triglyceride biosynthetic process (GO:0010867)2.70964090
55ectoderm development (GO:0007398)2.70885225
56positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.70178563
57DNA replication checkpoint (GO:0000076)2.69773015
58intestinal cholesterol absorption (GO:0030299)2.69500765
59dendritic cell chemotaxis (GO:0002407)2.68786496
60dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.68552832
61female gamete generation (GO:0007292)2.67864862
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.65928078
63regulation of mesoderm development (GO:2000380)2.64882104
64keratinocyte development (GO:0003334)2.64311822
65zinc ion transmembrane transport (GO:0071577)2.64105804
66immunoglobulin mediated immune response (GO:0016064)2.63845618
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.63797883
68positive regulation of humoral immune response (GO:0002922)2.63096732
69C-terminal protein lipidation (GO:0006501)2.62735503
70sulfate transmembrane transport (GO:1902358)2.62059127
71cyclooxygenase pathway (GO:0019371)2.60222311
72regulation of triglyceride biosynthetic process (GO:0010866)2.59859353
73regulation of apoptotic process involved in morphogenesis (GO:1902337)2.59264067
74regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58995194
75RNA-dependent DNA replication (GO:0006278)2.58988101
76notochord development (GO:0030903)2.58371203
77proline biosynthetic process (GO:0006561)2.57819188
78embryonic skeletal joint morphogenesis (GO:0060272)2.56263017
79extracellular negative regulation of signal transduction (GO:1900116)2.54826208
80extracellular regulation of signal transduction (GO:1900115)2.54826208
81cellular response to gamma radiation (GO:0071480)2.54805511
82proline metabolic process (GO:0006560)2.52475744
83positive regulation of keratinocyte differentiation (GO:0045618)2.50135713
84meiotic cell cycle (GO:0051321)2.49213455
85C-terminal protein amino acid modification (GO:0018410)2.49183215
86negative regulation of cell aging (GO:0090344)2.48731416
87positive regulation of antigen processing and presentation (GO:0002579)2.47189617
88interferon-gamma secretion (GO:0072643)2.46245231
89facial nerve structural organization (GO:0021612)2.45971531
90rRNA transcription (GO:0009303)2.45490400
91nucleotide-sugar biosynthetic process (GO:0009226)2.45046725
92DNA strand renaturation (GO:0000733)2.44791091
93trivalent inorganic anion homeostasis (GO:0072506)2.44431050
94phosphate ion homeostasis (GO:0055062)2.44431050
95establishment of apical/basal cell polarity (GO:0035089)2.43982857
96base-excision repair, AP site formation (GO:0006285)2.43950536
97negative regulation of T cell differentiation in thymus (GO:0033085)2.43855580
98regulation of water loss via skin (GO:0033561)2.43661145
99positive regulation of interleukin-1 production (GO:0032732)2.43631943
100DNA integration (GO:0015074)2.43603606
101sphingomyelin metabolic process (GO:0006684)2.42470373
102regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40616976
103kinetochore assembly (GO:0051382)2.40612072
104regulation of keratinocyte differentiation (GO:0045616)2.39177557
105positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.38123269
106nucleotide transmembrane transport (GO:1901679)2.37951119
107keratinization (GO:0031424)2.37738856
108regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.37022568
109regulation of mononuclear cell migration (GO:0071675)2.36981033
110dendritic cell migration (GO:0036336)2.35585203
111replicative senescence (GO:0090399)2.34993589
112regulation of mitochondrial translation (GO:0070129)2.34479732
113wound healing, spreading of epidermal cells (GO:0035313)2.34049725
114mitotic cell cycle arrest (GO:0071850)2.33288624
115establishment of monopolar cell polarity (GO:0061162)2.32923442
116establishment or maintenance of monopolar cell polarity (GO:0061339)2.32923442
117regulation of cell proliferation involved in kidney development (GO:1901722)2.32804645
1183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.32584837
119purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.32584837
120cellular modified amino acid catabolic process (GO:0042219)2.32494341
1214-hydroxyproline metabolic process (GO:0019471)2.32121142
122tRNA processing (GO:0008033)2.30937972
123neutrophil activation involved in immune response (GO:0002283)2.30816665
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.30715556
125cellular response to exogenous dsRNA (GO:0071360)2.30354597
126positive regulation of fatty acid oxidation (GO:0046321)2.29578980
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.29381966
128regulation of antigen processing and presentation (GO:0002577)2.29376619
129positive regulation of monocyte chemotaxis (GO:0090026)2.27987394
130regulation of interleukin-1 secretion (GO:0050704)2.27670483
131neutrophil activation (GO:0042119)2.27587190
132regulation of chemokine secretion (GO:0090196)2.26968646
133positive regulation of T cell chemotaxis (GO:0010820)2.26675284
134regulation of T cell chemotaxis (GO:0010819)2.26675284
135GPI anchor metabolic process (GO:0006505)2.26171690
136regulation of meiosis (GO:0040020)2.26050158
137myoblast migration (GO:0051451)2.25838825
138ceramide catabolic process (GO:0046514)2.25804863
139regulation of acrosome reaction (GO:0060046)2.25311720
140wound healing, spreading of cells (GO:0044319)2.24955754
141phosphatidylethanolamine biosynthetic process (GO:0006646)2.23723078
142regulation of Cdc42 GTPase activity (GO:0043088)2.23174216
143GPI anchor biosynthetic process (GO:0006506)2.23089557
144metaphase plate congression (GO:0051310)2.22720970
145positive regulation of fatty acid beta-oxidation (GO:0032000)2.22002621
146polarized epithelial cell differentiation (GO:0030859)2.21718220
147poly(A)+ mRNA export from nucleus (GO:0016973)2.21162252
148negative regulation of JAK-STAT cascade (GO:0046426)2.20780809
149negative regulation of smooth muscle cell differentiation (GO:0051151)2.20389207
150regulation of double-strand break repair via homologous recombination (GO:0010569)2.20374524
151lung secretory cell differentiation (GO:0061140)2.20216540
152negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.20194007
153DNA damage induced protein phosphorylation (GO:0006975)2.18571553
154L-methionine biosynthetic process (GO:0071265)2.18436361
155amino acid salvage (GO:0043102)2.18436361
156L-methionine salvage (GO:0071267)2.18436361
157ubiquinone biosynthetic process (GO:0006744)2.18198737
158cellular anion homeostasis (GO:0030002)2.17899360
159ncRNA 3-end processing (GO:0043628)2.16959032
160negative regulation of meiosis (GO:0045835)2.16409103
161DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.16037899
162kinetochore organization (GO:0051383)2.15377324
163response to X-ray (GO:0010165)2.15345562
164positive regulation of defense response to virus by host (GO:0002230)2.14805160
165regulation of fatty acid beta-oxidation (GO:0031998)2.14710100
166modulation by symbiont of host immune response (GO:0052553)2.14369604
167modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.14369604
168amyloid precursor protein catabolic process (GO:0042987)2.13853930
169response to food (GO:0032094)2.13641403
170sulfur amino acid catabolic process (GO:0000098)2.12014272
171phosphatidylethanolamine metabolic process (GO:0046337)2.11522536
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.11381114
173L-phenylalanine metabolic process (GO:0006558)2.11381114
174response to testosterone (GO:0033574)2.11201880
175tRNA metabolic process (GO:0006399)2.10972831
176zinc ion transport (GO:0006829)2.10556088
177mitochondrial RNA metabolic process (GO:0000959)2.10541171
178nucleoside transport (GO:0015858)2.09214417
179motile cilium assembly (GO:0044458)2.08201163
180methionine biosynthetic process (GO:0009086)2.07185786
181morphogenesis of embryonic epithelium (GO:0016331)2.06131074
182multicellular organismal water homeostasis (GO:0050891)2.06129661
183keratinocyte proliferation (GO:0043616)2.04116141
184magnesium ion transport (GO:0015693)2.03612602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.89023365
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.44605884
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.19957559
4PCGF2_27294783_Chip-Seq_ESCs_Mouse3.01783807
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.98982966
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.97755432
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95701866
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.94265228
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77546364
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.67298116
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55687122
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.53589645
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44010924
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.39250585
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.35469404
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34994624
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.22737133
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22218020
19KAP1_22055183_ChIP-Seq_ESCs_Mouse2.20111289
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.17070277
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.07155281
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03444524
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02478628
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02390541
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.00934695
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00680588
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99768643
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.99732238
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99403713
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99360513
31DCP1A_22483619_ChIP-Seq_HELA_Human1.96080694
32GBX2_23144817_ChIP-Seq_PC3_Human1.90489967
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.90162048
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88335348
35ZNF263_19887448_ChIP-Seq_K562_Human1.87910447
36* XRN2_22483619_ChIP-Seq_HELA_Human1.87344357
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.87175987
38GABP_19822575_ChIP-Seq_HepG2_Human1.86351265
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.84974329
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84410649
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83835342
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80619682
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.79519126
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79301485
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77673893
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77329303
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.76959874
48NMYC_18555785_Chip-Seq_ESCs_Mouse1.74715953
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73555949
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73370529
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.72733008
52P53_22387025_ChIP-Seq_ESCs_Mouse1.72355995
53RNF2_27304074_Chip-Seq_NSC_Mouse1.69623130
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68072595
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66489590
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65360476
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65136726
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64870570
59TP53_22127205_ChIP-Seq_IMR90_Human1.64035257
60KDM5A_27292631_Chip-Seq_BREAST_Human1.64033861
61ATF3_27146783_Chip-Seq_COLON_Human1.62299164
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.61458753
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.61095822
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60516152
65OCT4_18555785_Chip-Seq_ESCs_Mouse1.60045572
66P68_20966046_ChIP-Seq_HELA_Human1.54934162
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.53514078
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53372691
69P300_18555785_Chip-Seq_ESCs_Mouse1.52662211
70E2F1_20622854_ChIP-Seq_HELA_Human1.52487461
71PU1_27457419_Chip-Seq_LIVER_Mouse1.50545036
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.50432944
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.50368919
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50002480
75ZNF274_21170338_ChIP-Seq_K562_Hela1.49642236
76KLF4_18555785_Chip-Seq_ESCs_Mouse1.49043513
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.48677466
78RACK7_27058665_Chip-Seq_MCF-7_Human1.47279270
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.46436576
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45965897
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45325463
82CTCF_18555785_Chip-Seq_ESCs_Mouse1.41680858
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41175069
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39196006
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.38573975
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38301349
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38022758
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37516550
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.35653084
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35626834
91STAT1_17558387_ChIP-Seq_HELA_Human1.34577468
92E2F7_22180533_ChIP-Seq_HELA_Human1.33588276
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32599307
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32325593
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.31508277
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.31438771
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31127198
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30744694
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30558103
100CJUN_26792858_Chip-Seq_BT549_Human1.30311209
101* FOXP1_21924763_ChIP-Seq_HESCs_Human1.30300214
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.28281112
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28138814
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27294665
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26900667
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26441508
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.26041494
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25749413
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25735458
110RARB_24833708_ChIP-Seq_LIVER_Mouse1.23106104
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23034654
112* ERA_21632823_ChIP-Seq_H3396_Human1.22831900
113MYC_18940864_ChIP-ChIP_HL60_Human1.22745170
114PHF8_20622854_ChIP-Seq_HELA_Human1.22102692
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20822765
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19840165
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.19358251
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17684517
119* ESR1_21235772_ChIP-Seq_MCF-7_Human1.16559298
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16447768
121BCOR_27268052_Chip-Seq_Bcells_Human1.15279156
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15233481
123TP53_18474530_ChIP-ChIP_U2OS_Human1.14672619
124EWS_26573619_Chip-Seq_HEK293_Human1.14495024
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13776932
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12842992
127GATA3_24758297_ChIP-Seq_MCF-7_Human1.11656985
128* TTF2_22483619_ChIP-Seq_HELA_Human1.11563147
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11326582
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11180054
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10644480
132P300_19829295_ChIP-Seq_ESCs_Human1.10613956
133CTCF_20526341_ChIP-Seq_ESCs_Human1.10327256
134VDR_23849224_ChIP-Seq_CD4+_Human1.09753105
135TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09740706
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09395916
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09395916
138MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09293771
139NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08832958
140RARA_24833708_ChIP-Seq_LIVER_Mouse1.08605828
141E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08430105
142PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07870612
143GATA6_25053715_ChIP-Seq_YYC3_Human1.06082146
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05826929
145RAC3_21632823_ChIP-Seq_H3396_Human1.05812573
146CBX2_27304074_Chip-Seq_ESCs_Mouse1.05679170
147* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04437335
148P53_21459846_ChIP-Seq_SAOS-2_Human1.04027739
149CDX2_22108803_ChIP-Seq_LS180_Human1.03746628
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03543458
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03543458
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01506915
153ETV1_20927104_ChIP-Seq_GIST48_Human1.01267723
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00740482
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00170448
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99678679
157SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99535287
158RBPJ_21746931_ChIP-Seq_IB4_Human0.98825210
159AHR_22903824_ChIP-Seq_MCF-7_Human0.98811728
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98725401
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98370336
162ELF1_20517297_ChIP-Seq_JURKAT_Human0.98276610
163VDR_22108803_ChIP-Seq_LS180_Human0.98053077
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.97960868
165SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97953545
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.97858655
167RUNX1_27514584_Chip-Seq_MCF-7_Human0.97793561
168STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97720442
169PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97586800
170FUS_26573619_Chip-Seq_HEK293_Human0.97555313
171TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97493476
172E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97469163
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.97460479
174BCL6_27268052_Chip-Seq_Bcells_Human0.97193004
175GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97181955
176EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96946644
177RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96879115
178CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96282028
179* TP63_22573176_ChIP-Seq_HFKS_Human0.96250717
180PIAS1_25552417_ChIP-Seq_VCAP_Human0.96163839
181GATA4_25053715_ChIP-Seq_YYC3_Human0.95681856
182PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95534269
183ERG_21242973_ChIP-ChIP_JURKAT_Human0.95453242
184TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94928991
185PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93996402
186FOXP3_21729870_ChIP-Seq_TREG_Human0.93663376
187SMAD4_21799915_ChIP-Seq_A2780_Human0.93519081
188UBF1/2_26484160_Chip-Seq_HMECs_Human0.93231489
189YY1_22570637_ChIP-Seq_MALME-3M_Human0.93125180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.64060019
2MP0005451_abnormal_body_composition3.28787270
3MP0002234_abnormal_pharynx_morphology3.26564121
4MP0003941_abnormal_skin_development3.21436268
5MP0000566_synostosis3.06775591
6MP0004782_abnormal_surfactant_physiolog2.93660104
7MP0002254_reproductive_system_inflammat2.93396043
8MP0001188_hyperpigmentation2.86303453
9MP0008875_abnormal_xenobiotic_pharmacok2.84812973
10MP0003718_maternal_effect2.79039641
11MP0010234_abnormal_vibrissa_follicle2.66050110
12MP0006292_abnormal_olfactory_placode2.62017585
13MP0002796_impaired_skin_barrier2.57287594
14MP0010678_abnormal_skin_adnexa2.44113822
15MP0005501_abnormal_skin_physiology2.39564244
16MP0002102_abnormal_ear_morphology2.25041503
17MP0002277_abnormal_respiratory_mucosa2.24937234
18MP0009780_abnormal_chondrocyte_physiolo2.16941764
19MP0005083_abnormal_biliary_tract2.09255069
20MP0002148_abnormal_hypersensitivity_rea2.09134816
21MP0008004_abnormal_stomach_pH2.06012582
22MP0005360_urolithiasis2.03858279
23MP0000579_abnormal_nail_morphology2.00331247
24MP0002160_abnormal_reproductive_system1.94565454
25MP0000467_abnormal_esophagus_morphology1.93983042
26MP0003787_abnormal_imprinting1.87033335
27MP0000013_abnormal_adipose_tissue1.85758844
28MP0010030_abnormal_orbit_morphology1.84186378
29MP0001119_abnormal_female_reproductive1.84176681
30MP0010386_abnormal_urinary_bladder1.80225102
31MP0008260_abnormal_autophagy1.79885127
32MP0001346_abnormal_lacrimal_gland1.79250247
33MP0010771_integument_phenotype1.77362188
34MP0000537_abnormal_urethra_morphology1.67213917
35MP0002132_abnormal_respiratory_system1.67120155
36MP0000490_abnormal_crypts_of1.65009701
37MP0008007_abnormal_cellular_replicative1.64978972
38MP0003315_abnormal_perineum_morphology1.64590815
39MP0009053_abnormal_anal_canal1.64097579
40MP0003693_abnormal_embryo_hatching1.61634021
41MP0000015_abnormal_ear_pigmentation1.60806677
42MP0003195_calcinosis1.60244885
43MP0001835_abnormal_antigen_presentation1.60056008
44MP0000762_abnormal_tongue_morphology1.55880731
45MP0002060_abnormal_skin_morphology1.55421591
46MP0008058_abnormal_DNA_repair1.52929225
47MP0000678_abnormal_parathyroid_gland1.52146003
48MP0003786_premature_aging1.52129117
49MP0002163_abnormal_gland_morphology1.50309978
50MP0008995_early_reproductive_senescence1.49439458
51MP0010094_abnormal_chromosome_stability1.49363266
52MP0005377_hearing/vestibular/ear_phenot1.49038663
53MP0003878_abnormal_ear_physiology1.49038663
54MP0002249_abnormal_larynx_morphology1.48529717
55MP0000383_abnormal_hair_follicle1.47223303
56MP0003950_abnormal_plasma_membrane1.41657982
57MP0003136_yellow_coat_color1.40565743
58MP0002098_abnormal_vibrissa_morphology1.39466004
59MP0001661_extended_life_span1.39297661
60MP0005310_abnormal_salivary_gland1.36532259
61MP0000003_abnormal_adipose_tissue1.36373439
62MP0003724_increased_susceptibility_to1.35584107
63MP0002282_abnormal_trachea_morphology1.31396352
64MP0009785_altered_susceptibility_to1.31374179
65MP0003111_abnormal_nucleus_morphology1.30174478
66MP0009384_cardiac_valve_regurgitation1.27759032
67MP0005275_abnormal_skin_tensile1.25499446
68MP0005395_other_phenotype1.23842063
69MP0005257_abnormal_intraocular_pressure1.22864214
70MP0008877_abnormal_DNA_methylation1.20979429
71MP0002177_abnormal_outer_ear1.20224951
72MP0010155_abnormal_intestine_physiology1.20155276
73MP0000427_abnormal_hair_cycle1.19708598
74MP0000377_abnormal_hair_follicle1.18462920
75MP0004381_abnormal_hair_follicle1.16262265
76MP0003755_abnormal_palate_morphology1.14154333
77MP0002876_abnormal_thyroid_physiology1.13945394
78MP0002009_preneoplasia1.13765398
79MP0005365_abnormal_bile_salt1.12661727
80MP0005408_hypopigmentation1.11566822
81MP0002419_abnormal_innate_immunity1.11268625
82MP0005367_renal/urinary_system_phenotyp1.10693960
83MP0000516_abnormal_urinary_system1.10693960
84MP0005379_endocrine/exocrine_gland_phen1.10692918
85MP0001919_abnormal_reproductive_system1.10549072
86MP0005671_abnormal_response_to1.09676174
87MP0009697_abnormal_copulation1.07822549
88MP0000681_abnormal_thyroid_gland1.06665496
89MP0005423_abnormal_somatic_nervous1.06324061
90MP0005332_abnormal_amino_acid1.05727144
91MP0008789_abnormal_olfactory_epithelium1.05603387
92MP0004133_heterotaxia1.04118334
93MP0003119_abnormal_digestive_system1.03790576
94MP0000569_abnormal_digit_pigmentation1.03459853
95MP0005646_abnormal_pituitary_gland1.03376931
96MP0002405_respiratory_system_inflammati1.02600279
97MP0002089_abnormal_postnatal_growth/wei1.02240195
98MP0009840_abnormal_foam_cell1.01789245
99MP0003763_abnormal_thymus_physiology1.01402144
100MP0000372_irregular_coat_pigmentation1.00855601
101MP0003806_abnormal_nucleotide_metabolis1.00730236
102MP0006072_abnormal_retinal_apoptosis1.00252213
103MP0003699_abnormal_female_reproductive0.99943110
104MP0000613_abnormal_salivary_gland0.99039090
105MP0005220_abnormal_exocrine_pancreas0.98668736
106MP0003942_abnormal_urinary_system0.98624862
107MP0009333_abnormal_splenocyte_physiolog0.98384835
108MP0005174_abnormal_tail_pigmentation0.98203993
109MP0004233_abnormal_muscle_weight0.97306653
110MP0009764_decreased_sensitivity_to0.96899969
111MP0003453_abnormal_keratinocyte_physiol0.94923903
112MP0001944_abnormal_pancreas_morphology0.94171173
113MP0001790_abnormal_immune_system0.93987587
114MP0005387_immune_system_phenotype0.93987587
115MP0001764_abnormal_homeostasis0.93862886
116MP0002452_abnormal_antigen_presenting0.93575736
117MP0003436_decreased_susceptibility_to0.93522623
118MP0005551_abnormal_eye_electrophysiolog0.92330581
119MP0002295_abnormal_pulmonary_circulatio0.91455637
120MP0005000_abnormal_immune_tolerance0.91445466
121MP0005389_reproductive_system_phenotype0.90960535
122MP0001216_abnormal_epidermal_layer0.90141216
123MP0000627_abnormal_mammary_gland0.89784017
124MP0005023_abnormal_wound_healing0.88695184
125MP0004185_abnormal_adipocyte_glucose0.86750067
126MP0000049_abnormal_middle_ear0.86456740
127MP0003077_abnormal_cell_cycle0.86292856
128MP0002723_abnormal_immune_serum0.86194860
129MP0003937_abnormal_limbs/digits/tail_de0.85845326
130MP0000465_gastrointestinal_hemorrhage0.85839062
131MP0000367_abnormal_coat/_hair0.85718994
132MP0001542_abnormal_bone_strength0.85070172
133MP0001664_abnormal_digestion0.84779891
134MP0002095_abnormal_skin_pigmentation0.84714004
135MP0003191_abnormal_cellular_cholesterol0.84586785
136MP0005025_abnormal_response_to0.82888424
137MP0002837_dystrophic_cardiac_calcinosis0.82829268
138MP0002210_abnormal_sex_determination0.82756731
139MP0001968_abnormal_touch/_nociception0.82491177
140MP0000767_abnormal_smooth_muscle0.82428547
141MP0001756_abnormal_urination0.81845540
142MP0001243_abnormal_dermal_layer0.79605649
143MP0000538_abnormal_urinary_bladder0.79578978
144MP0003828_pulmonary_edema0.79356111
145MP0001800_abnormal_humoral_immune0.78504451
146MP0005508_abnormal_skeleton_morphology0.78488577
147MP0001270_distended_abdomen0.77630334
148MP0000470_abnormal_stomach_morphology0.77457934
149MP0008932_abnormal_embryonic_tissue0.77274081
150MP0004019_abnormal_vitamin_homeostasis0.76996942
151MP0004885_abnormal_endolymph0.75610371
152MP0002396_abnormal_hematopoietic_system0.75533310
153MP0002111_abnormal_tail_morphology0.75065438
154MP0001819_abnormal_immune_cell0.74592739
155MP0000653_abnormal_sex_gland0.73908444
156MP0000647_abnormal_sebaceous_gland0.73899033
157MP0001873_stomach_inflammation0.73099361
158MP0003936_abnormal_reproductive_system0.71998321
159MP0009931_abnormal_skin_appearance0.71878863
160MP0003879_abnormal_hair_cell0.71265879
161MP0004043_abnormal_pH_regulation0.71127634
162MP0000534_abnormal_ureter_morphology0.68242661

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.66759610
2Chromsome breakage (HP:0040012)5.36664603
3Prostate neoplasm (HP:0100787)4.09291515
4Abnormality of the preputium (HP:0100587)3.35560024
5Poikiloderma (HP:0001029)3.19190710
6Lip pit (HP:0100267)3.11728540
7Clubbing of toes (HP:0100760)3.01370355
8Abnormality of the renal collecting system (HP:0004742)2.97152210
9Duplicated collecting system (HP:0000081)2.91815477
10Aplasia/Hypoplasia of the uvula (HP:0010293)2.83342284
11Hypergonadotropic hypogonadism (HP:0000815)2.83177704
12Squamous cell carcinoma (HP:0002860)2.78715742
13Meckel diverticulum (HP:0002245)2.76432475
14Recurrent abscess formation (HP:0002722)2.75528089
15Concave nail (HP:0001598)2.74562870
16Abnormality of the nasal septum (HP:0000419)2.70736061
17Abnormality of nail color (HP:0100643)2.65970647
18Abnormality of chromosome stability (HP:0003220)2.65726079
19Retrobulbar optic neuritis (HP:0100654)2.65398217
20Optic neuritis (HP:0100653)2.65398217
21Attenuation of retinal blood vessels (HP:0007843)2.59191210
22Abnormality of the ileum (HP:0001549)2.56697762
23Hypoplasia of the fovea (HP:0007750)2.55467115
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.55467115
25Testicular atrophy (HP:0000029)2.54245345
26Distal lower limb muscle weakness (HP:0009053)2.52499732
27Tubular atrophy (HP:0000092)2.52159277
28Molar tooth sign on MRI (HP:0002419)2.50844977
29Abnormality of midbrain morphology (HP:0002418)2.50844977
30Aplasia cutis congenita (HP:0001057)2.47903179
31Fragile nails (HP:0001808)2.46984862
32Ectropion (HP:0000656)2.44396922
33Abnormality of the prostate (HP:0008775)2.43571481
34Stomach cancer (HP:0012126)2.43167491
35Thick nail (HP:0001805)2.42062464
36Ectopic kidney (HP:0000086)2.40438747
37Congenital, generalized hypertrichosis (HP:0004540)2.39473756
38Mesangial abnormality (HP:0001966)2.37903010
39Urethral obstruction (HP:0000796)2.37075005
40Flat capital femoral epiphysis (HP:0003370)2.36150104
41Alopecia of scalp (HP:0002293)2.34515197
42Abnormality of the distal phalanges of the toes (HP:0010182)2.34035968
43Amelogenesis imperfecta (HP:0000705)2.31427004
44Congenital stationary night blindness (HP:0007642)2.31296112
45Entropion (HP:0000621)2.31158896
46Type II lissencephaly (HP:0007260)2.29448418
47Pancreatic cysts (HP:0001737)2.28710211
48Chorioretinal atrophy (HP:0000533)2.27442578
49Eczematoid dermatitis (HP:0000976)2.27422137
50Microretrognathia (HP:0000308)2.25936082
51Cerebellar dysplasia (HP:0007033)2.23951504
52Popliteal pterygium (HP:0009756)2.23877662
53Duodenal stenosis (HP:0100867)2.22994158
54Small intestinal stenosis (HP:0012848)2.22994158
55Orchitis (HP:0100796)2.22797673
56Congenital sensorineural hearing impairment (HP:0008527)2.22746022
57Abnormality of DNA repair (HP:0003254)2.21700520
58Congenital ichthyosiform erythroderma (HP:0007431)2.21378910
59Hypoplasia of the uterus (HP:0000013)2.20349434
60Pendular nystagmus (HP:0012043)2.17576676
61Palmoplantar hyperkeratosis (HP:0000972)2.15074831
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14135587
63Pterygium (HP:0001059)2.13697021
64Pustule (HP:0200039)2.13514611
65Alveolar cell carcinoma (HP:0006519)2.13396046
66Septate vagina (HP:0001153)2.13036272
67Renal cortical cysts (HP:0000803)2.12907436
68Birth length less than 3rd percentile (HP:0003561)2.12160825
69Abnormality of the fovea (HP:0000493)2.10997708
70Vascular calcification (HP:0004934)2.10606883
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09752290
72Adrenal hypoplasia (HP:0000835)2.08893331
73Hypoplasia of the pons (HP:0012110)2.06847598
74Oligodontia (HP:0000677)2.05864238
75Severe muscular hypotonia (HP:0006829)2.05372941
76Abnormality of incisor morphology (HP:0011063)2.05156030
77Neonatal respiratory distress (HP:0002643)2.04289389
78Upper limb muscle weakness (HP:0003484)2.03876891
79Erythroderma (HP:0001019)2.03746302
80Submucous cleft hard palate (HP:0000176)2.03012356
81Recurrent bacterial skin infections (HP:0005406)2.01194286
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00360523
83Sclerocornea (HP:0000647)2.00212489
84Abnormality of proline metabolism (HP:0010907)1.98195480
85Hydroxyprolinuria (HP:0003080)1.98195480
86Duplication of thumb phalanx (HP:0009942)1.97833905
87Abnormality of the proximal phalanges of the hand (HP:0009834)1.97761118
88Brittle hair (HP:0002299)1.97218329
89Abnormality of the pons (HP:0007361)1.96228618
90Palmar hyperkeratosis (HP:0010765)1.96140872
91Short nail (HP:0001799)1.94048092
92Neoplasm of the tracheobronchial system (HP:0100552)1.93634331
93Patellar aplasia (HP:0006443)1.92172287
94Hypoalbuminemia (HP:0003073)1.91985130
95Abnormal albumin level (HP:0012116)1.91985130
96Hypophosphatemic rickets (HP:0004912)1.89305625
97Bony spicule pigmentary retinopathy (HP:0007737)1.88152392
98Anhidrosis (HP:0000970)1.87544377
99Natal tooth (HP:0000695)1.87470126
100Morphological abnormality of the middle ear (HP:0008609)1.86854808
101Cardiovascular calcification (HP:0011915)1.86425080
102Short chin (HP:0000331)1.85604293
103Onycholysis (HP:0001806)1.85538642
104Myositis (HP:0100614)1.85163048
105Myelodysplasia (HP:0002863)1.84999622
106Pili torti (HP:0003777)1.83822602
107True hermaphroditism (HP:0010459)1.83307645
108Hypotrichosis (HP:0001006)1.82705765
109Type I transferrin isoform profile (HP:0003642)1.82626117
110Cystic liver disease (HP:0006706)1.81479692
111Prolonged neonatal jaundice (HP:0006579)1.81263973
112Ulnar bowing (HP:0003031)1.81190154
113Shawl scrotum (HP:0000049)1.80717379
114Premature loss of primary teeth (HP:0006323)1.80664207
115Aplasia/Hypoplasia of the patella (HP:0006498)1.80051302
116Triphalangeal thumb (HP:0001199)1.78983792
117Abnormality of male internal genitalia (HP:0000022)1.78290924
118Bone marrow hypocellularity (HP:0005528)1.77650312
119Abnormality of placental membranes (HP:0011409)1.77537198
120Amniotic constriction ring (HP:0009775)1.77537198
121Aplasia of the musculature (HP:0100854)1.77318062
122Nail dystrophy (HP:0008404)1.77277125
123Nephronophthisis (HP:0000090)1.76581735
124Furrowed tongue (HP:0000221)1.75990204
125Type 2 muscle fiber atrophy (HP:0003554)1.75135157
126Short thumb (HP:0009778)1.74012860
127Aplasia/hypoplasia of the uterus (HP:0008684)1.73463554
128Abnormal hair laboratory examination (HP:0003328)1.72903736
129Abnormality of the duodenum (HP:0002246)1.72627975
130Right ventricular cardiomyopathy (HP:0011663)1.71493332
131Recurrent cutaneous fungal infections (HP:0011370)1.71188548
132Chronic mucocutaneous candidiasis (HP:0002728)1.71188548
133Prolonged partial thromboplastin time (HP:0003645)1.71038644
134Periodontitis (HP:0000704)1.70688783
135Xerostomia (HP:0000217)1.70436206
136Short humerus (HP:0005792)1.69961301
137Abnormality of the carotid arteries (HP:0005344)1.69741530
138Cheilitis (HP:0100825)1.69274821
139Slow-growing hair (HP:0002217)1.68630304
140Abnormality of hair growth rate (HP:0011363)1.68630304
141Breast hypoplasia (HP:0003187)1.68522661
142Plantar hyperkeratosis (HP:0007556)1.68228313
143Tubulointerstitial nephritis (HP:0001970)1.68012438
144Conical tooth (HP:0000698)1.67710844
145Acute myeloid leukemia (HP:0004808)1.67677458
146Abnormality of alanine metabolism (HP:0010916)1.67506090
147Hyperalaninemia (HP:0003348)1.67506090
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67506090
149Bowing of the arm (HP:0006488)1.67152388
150Bowed forearm bones (HP:0003956)1.67152388
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66168972
152Atrophic scars (HP:0001075)1.65393930
153Short femoral neck (HP:0100864)1.64702681
154Pulmonary fibrosis (HP:0002206)1.63908007
155Nonprogressive disorder (HP:0003680)1.63691495
156Absent thumb (HP:0009777)1.63340502
157Unilateral renal agenesis (HP:0000122)1.63111927
158Polydipsia (HP:0001959)1.62603131
159Abnormal drinking behavior (HP:0030082)1.62603131
160Insulin-resistant diabetes mellitus (HP:0000831)1.61323580
161Milia (HP:0001056)1.61110408
162Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60533097
163Abnormal glycosylation (HP:0012345)1.60137067
164Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.60137067
165Abnormal protein N-linked glycosylation (HP:0012347)1.60137067
166Abnormal protein glycosylation (HP:0012346)1.60137067
167Abnormality of the renal cortex (HP:0011035)1.59735332
168Ureteral duplication (HP:0000073)1.59009007
169Pulmonary artery stenosis (HP:0004415)1.58847639
170Sparse eyelashes (HP:0000653)1.58485482
171Decreased circulating renin level (HP:0003351)1.58177650
172Abnormality of molar (HP:0011077)1.57466596
173Abnormality of molar morphology (HP:0011070)1.57466596
174Parakeratosis (HP:0001036)1.57038046
175Aplasia/hypoplasia of the humerus (HP:0006507)1.56974727
176Breech presentation (HP:0001623)1.56715170
177Pancreatic fibrosis (HP:0100732)1.56705253
178Abnormality of the renal medulla (HP:0100957)1.55890297
179Anomalous pulmonary venous return (HP:0010772)1.55636404
180Breast aplasia (HP:0100783)1.55106585
181Osteolytic defects of the hand bones (HP:0009699)1.54872957
182Osteolytic defects of the phalanges of the hand (HP:0009771)1.54872957
183Long foot (HP:0001833)1.53938493
184Absent radius (HP:0003974)1.53263233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.62904771
2STK38L3.22437381
3ZAK3.16261400
4TLK12.97559445
5WNK42.87035470
6BMPR22.76023631
7TAOK32.67929930
8PLK42.67724253
9BLK2.55277461
10AKT32.46271841
11LATS12.38538399
12TXK2.34932472
13CASK2.33619082
14MAP3K142.32721038
15MET2.31817714
16TRIM282.19506896
17INSRR2.00844085
18MAPK151.96755609
19IRAK41.91732610
20TRPM71.91169230
21EIF2AK21.86543094
22TTK1.77090541
23STK161.75720242
24LMTK21.71943507
25VRK21.70477482
26EIF2AK11.68199602
27SMG11.68019081
28NME11.61383712
29EPHA21.61251743
30MKNK21.56496459
31ICK1.54870926
32STK391.54506973
33BRAF1.53033103
34BMPR1B1.51544535
35ERBB31.51018242
36ERBB41.48129379
37CDK81.46588044
38FRK1.43398513
39SIK11.40912511
40STK31.39613213
41STK241.38445140
42MUSK1.37726296
43TRIB31.37187308
44PRKCI1.37151353
45MOS1.35340949
46LATS21.27721996
47TEC1.26638820
48JAK31.26095031
49NEK61.25300004
50BUB11.24927296
51NUAK11.21088751
52MAP3K91.20265196
53TGFBR21.20216468
54NEK91.18568970
55LIMK11.13929263
56PTK21.13057168
57IKBKB1.12649674
58SGK21.07961032
59MAP3K61.05316060
60IKBKE1.04139565
61PHKG11.04002482
62PHKG21.04002482
63AURKA1.02995727
64CHUK1.01930381
65ABL21.01577789
66YES11.00039436
67ADRBK20.99112713
68SIK30.95904093
69PIK3CG0.93056890
70GRK70.92320161
71GRK10.90951340
72NLK0.88165116
73MKNK10.87946222
74ADRBK10.87715994
75TESK20.87573155
76MAPKAPK30.86694606
77STK100.85591892
78MST1R0.84347082
79PLK10.81794370
80CSNK1G30.78838627
81BCR0.77370870
82PIM20.76857822
83TESK10.75397937
84VRK10.75212271
85MAPK130.74082915
86FLT30.73857742
87CSNK1A1L0.73377113
88PRPF4B0.72300000
89PLK30.71935245
90EIF2AK30.71310969
91CDK30.71276991
92CHEK20.70316003
93MST40.70037944
94PINK10.69153913
95ARAF0.68222325
96PKN20.67622721
97PAK40.67541291
98AURKB0.66874283
99PRKD20.63882266
100EPHA30.62905074
101SRPK10.62903774
102TAF10.62573189
103MAPK110.62412932
104PRKD30.62379087
105MAP2K70.62374672
106PBK0.62172432
107CLK10.61315807
108RPS6KA20.60340706
109PLK20.59161669
110MAPKAPK50.58398400
111ILK0.57893138
112BRSK20.54249353
113DAPK10.53947840
114EPHB20.52982804
115EEF2K0.51939099
116MYLK0.51625622
117STK40.51474705
118MAP3K30.51110741
119MELK0.50742562
120CSNK1G10.50316796
121MTOR0.49819936
122MAP3K120.49718273
123PIM10.49623745
124RPS6KA60.49379845
125MAP3K130.47965642
126MAP2K20.45934644
127RPS6KA40.45509740
128TGFBR10.43849387
129STK380.43059451
130NME20.42259501
131PRKAA10.42124427
132MAP2K60.41251530
133FER0.41109763
134IRAK10.39580299
135ATR0.39395679
136IRAK20.39242918
137TNIK0.39039266
138PDK20.38993196
139TAOK20.38718301
140WNK30.38328950
141RPS6KA50.38107487
142PRKAA20.36842446
143SGK30.36466477
144PIK3CA0.34733327
145ABL10.34543470
146RPS6KB20.34520731
147PRKCE0.34468928
148SGK4940.34302951
149SGK2230.34302951
150CDK90.33941411
151MAP4K20.33666427
152LYN0.33639035
153CDK70.31476876
154DYRK20.30573056
155NEK20.30194337

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.68823678
2Sulfur relay system_Homo sapiens_hsa041223.40718169
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.16681653
4Fanconi anemia pathway_Homo sapiens_hsa034602.49675725
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40218413
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.26119485
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.24292819
8Selenocompound metabolism_Homo sapiens_hsa004502.19199294
9Arachidonic acid metabolism_Homo sapiens_hsa005902.11936450
10Basal transcription factors_Homo sapiens_hsa030222.03669810
11Vitamin B6 metabolism_Homo sapiens_hsa007501.97871865
12Other glycan degradation_Homo sapiens_hsa005111.92069005
13Sulfur metabolism_Homo sapiens_hsa009201.91197391
14Homologous recombination_Homo sapiens_hsa034401.90992546
15Allograft rejection_Homo sapiens_hsa053301.87285384
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86499712
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86179389
18Graft-versus-host disease_Homo sapiens_hsa053321.86089026
19Steroid biosynthesis_Homo sapiens_hsa001001.79357421
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76013471
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.74561465
22Autoimmune thyroid disease_Homo sapiens_hsa053201.73534058
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.73385199
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.70057815
25RNA degradation_Homo sapiens_hsa030181.68293347
26Sphingolipid metabolism_Homo sapiens_hsa006001.67898524
27One carbon pool by folate_Homo sapiens_hsa006701.67815554
28RNA polymerase_Homo sapiens_hsa030201.63775485
29Ovarian steroidogenesis_Homo sapiens_hsa049131.57127464
30Non-homologous end-joining_Homo sapiens_hsa034501.54980678
31p53 signaling pathway_Homo sapiens_hsa041151.54771197
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53907903
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47999146
34Base excision repair_Homo sapiens_hsa034101.46764928
35Cell cycle_Homo sapiens_hsa041101.44880097
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42641094
37Nitrogen metabolism_Homo sapiens_hsa009101.42199643
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40505685
39Measles_Homo sapiens_hsa051621.37963358
40Linoleic acid metabolism_Homo sapiens_hsa005911.35597683
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34696927
42Ether lipid metabolism_Homo sapiens_hsa005651.33609056
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31384276
44Influenza A_Homo sapiens_hsa051641.30156262
45Rheumatoid arthritis_Homo sapiens_hsa053231.28240200
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27817220
47N-Glycan biosynthesis_Homo sapiens_hsa005101.25555287
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25242239
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24839686
50Regulation of autophagy_Homo sapiens_hsa041401.24763553
51Herpes simplex infection_Homo sapiens_hsa051681.23398241
52Fatty acid biosynthesis_Homo sapiens_hsa000611.21727849
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21260248
54Fructose and mannose metabolism_Homo sapiens_hsa000511.21034239
55Circadian rhythm_Homo sapiens_hsa047101.20746043
56Caffeine metabolism_Homo sapiens_hsa002321.20473516
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.20330772
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.15780867
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.15603113
60TNF signaling pathway_Homo sapiens_hsa046681.13701414
61Leishmaniasis_Homo sapiens_hsa051401.13502866
62Chemical carcinogenesis_Homo sapiens_hsa052041.11329298
63Hematopoietic cell lineage_Homo sapiens_hsa046401.11286935
64Malaria_Homo sapiens_hsa051441.10418117
65Asthma_Homo sapiens_hsa053101.07633115
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06784843
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.00470682
68Arginine and proline metabolism_Homo sapiens_hsa003300.99143623
69Butanoate metabolism_Homo sapiens_hsa006500.96495139
70Pyruvate metabolism_Homo sapiens_hsa006200.96075675
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95470391
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93918572
73Protein export_Homo sapiens_hsa030600.93816238
74Metabolic pathways_Homo sapiens_hsa011000.93568217
75Basal cell carcinoma_Homo sapiens_hsa052170.93102346
76ABC transporters_Homo sapiens_hsa020100.92089175
77Phenylalanine metabolism_Homo sapiens_hsa003600.91811972
78Nucleotide excision repair_Homo sapiens_hsa034200.90585847
79Apoptosis_Homo sapiens_hsa042100.89712795
80Toxoplasmosis_Homo sapiens_hsa051450.88270420
81Tuberculosis_Homo sapiens_hsa051520.87571398
82Fat digestion and absorption_Homo sapiens_hsa049750.87521022
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86973157
84TGF-beta signaling pathway_Homo sapiens_hsa043500.85942383
85Pyrimidine metabolism_Homo sapiens_hsa002400.85717435
86Tryptophan metabolism_Homo sapiens_hsa003800.85593964
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.85249698
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84356318
89Oxidative phosphorylation_Homo sapiens_hsa001900.84167097
90Legionellosis_Homo sapiens_hsa051340.83644640
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81415793
92Type I diabetes mellitus_Homo sapiens_hsa049400.81352058
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80710053
94Purine metabolism_Homo sapiens_hsa002300.79619241
95beta-Alanine metabolism_Homo sapiens_hsa004100.79489904
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79279195
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78672767
98Bladder cancer_Homo sapiens_hsa052190.78420085
99Proteasome_Homo sapiens_hsa030500.78283738
100DNA replication_Homo sapiens_hsa030300.77093145
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76667447
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76440161
103Folate biosynthesis_Homo sapiens_hsa007900.75322538
104Vitamin digestion and absorption_Homo sapiens_hsa049770.73444050
105Phagosome_Homo sapiens_hsa041450.68698084
106Melanoma_Homo sapiens_hsa052180.68589463
107Osteoclast differentiation_Homo sapiens_hsa043800.68452287
108Retinol metabolism_Homo sapiens_hsa008300.68412329
109Mismatch repair_Homo sapiens_hsa034300.68210780
110Staphylococcus aureus infection_Homo sapiens_hsa051500.67423499
111Histidine metabolism_Homo sapiens_hsa003400.66602891
112Peroxisome_Homo sapiens_hsa041460.66498123
113Hedgehog signaling pathway_Homo sapiens_hsa043400.66245269
114Primary immunodeficiency_Homo sapiens_hsa053400.65794830
115MicroRNAs in cancer_Homo sapiens_hsa052060.64966979
116Adherens junction_Homo sapiens_hsa045200.64707301
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64384293
118Tyrosine metabolism_Homo sapiens_hsa003500.63549165
119Hepatitis B_Homo sapiens_hsa051610.63472272
120Huntingtons disease_Homo sapiens_hsa050160.61619796
121Pertussis_Homo sapiens_hsa051330.61475983
122Fatty acid elongation_Homo sapiens_hsa000620.61475601
123Small cell lung cancer_Homo sapiens_hsa052220.61396611
124Prolactin signaling pathway_Homo sapiens_hsa049170.59449055
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58610592
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58315373
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56586713
128RNA transport_Homo sapiens_hsa030130.56051592
129Epstein-Barr virus infection_Homo sapiens_hsa051690.55780063
130ECM-receptor interaction_Homo sapiens_hsa045120.54747159
131FoxO signaling pathway_Homo sapiens_hsa040680.54555928
132Glycerolipid metabolism_Homo sapiens_hsa005610.53832142
133Arginine biosynthesis_Homo sapiens_hsa002200.53829762
134Mineral absorption_Homo sapiens_hsa049780.53158864
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.53137623
136Biosynthesis of amino acids_Homo sapiens_hsa012300.52489032
137Lysine degradation_Homo sapiens_hsa003100.52314559
138Hippo signaling pathway_Homo sapiens_hsa043900.51736348
139Pancreatic cancer_Homo sapiens_hsa052120.50680191
140Phototransduction_Homo sapiens_hsa047440.50421014
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48914653
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48650263
143Hepatitis C_Homo sapiens_hsa051600.48019802
144Antigen processing and presentation_Homo sapiens_hsa046120.47828185
145HTLV-I infection_Homo sapiens_hsa051660.46823698
146Glutathione metabolism_Homo sapiens_hsa004800.46460130
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46222022
148Galactose metabolism_Homo sapiens_hsa000520.46115063
149Vibrio cholerae infection_Homo sapiens_hsa051100.45580893
150Lysosome_Homo sapiens_hsa041420.45485472
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.44778063
152Taste transduction_Homo sapiens_hsa047420.44349771
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40485494
154Notch signaling pathway_Homo sapiens_hsa043300.40443292
155Chemokine signaling pathway_Homo sapiens_hsa040620.39869634
156Salmonella infection_Homo sapiens_hsa051320.39305328
157Prostate cancer_Homo sapiens_hsa052150.38906639
158Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38398626
159Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35962360
160Inositol phosphate metabolism_Homo sapiens_hsa005620.34658412
161Shigellosis_Homo sapiens_hsa051310.34549286
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33819177

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